{"id":57299,"date":"2024-02-27T17:35:45","date_gmt":"2024-02-27T17:35:45","guid":{"rendered":"https:\/\/medsname.com\/hydrocl\/"},"modified":"2026-05-01T10:49:13","modified_gmt":"2026-05-01T10:49:13","slug":"hydrocl","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/hydrocl\/","title":{"rendered":"Hydrocl"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Hydrocl?<\/h3>\n<p style=\"margin:0;\"><strong>Hydrocl<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 <strong>12.5 \/ 25 mg hydrochlorothiazide tablet<\/strong> from a WHO-GMP certified manufacturer &mdash; a <strong>thiazide diuretic (benzothiadiazine sulfonamide)<\/strong> \u03c0\u03bf\u03c5 \u03b4\u03c1\u03b1 \u03c3\u03c4\u03bf\u03bd <strong>NCC (sodium-chloride cotransporter) in the distal convoluted tubule<\/strong>. Hydrochlorothiazide was introduced in 1959 by Merck Sharp &amp; Dohme as <strong>HydroDiuril<\/strong> &mdash; derived from sulfanilamide during the sulfonamide-antibiotic programme when its diuretic activity was noticed serendipitously. HCTZ became the reference thiazide and has been a first-line antihypertensive ever since. Half-life 6-15 hours; onset 2 hours; peak effect 4-6 hours; duration 6-12 hours. Primary indication: <strong>hypertension (first-line; guideline-recommended alongside ARB, ACEi, and CCB)<\/strong>. Typical dosing: Start 12.5 mg once daily in the morning. Target 12.5-25 mg. <strong>Do not exceed 25 mg<\/strong> for hypertension &mdash; higher doses give diminishing returns on BP but worsen metabolic side effects (urate, glucose, lipids). Modern guidelines have moved away from the historical 50 mg antihypertensive dose. Key contraindications: see full list below. Monitor electrolytes, creatinine, and glucose. <strong>\u039c\u03b7\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03bb\u03af\u03b8\u03b9\u03bf<\/strong> (\u03c4\u03b1 \u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b9\u03b1\/\u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03b2\u03c1\u03cc\u03c7\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03bf\u03c5\u03bd \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bb\u03b9\u03b8\u03af\u03bf\u03c5). <strong>\u0397 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03bd\u03ac \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7<\/strong> (\u03b2\u03bb. \u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7\u03c2). \u0393\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5\u03c2 \u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2, \u03c4\u03b1 \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03c9\u03c2 <strong>\u03c4\u03bf \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03bf \u03ae \u03c4\u03c1\u03af\u03c4\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf<\/strong> \u2014 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 ARB, \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 ACE \u03ae \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 \u03b4\u03b9\u03b1\u03cd\u03bb\u03c9\u03bd \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03b1.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong> \u03a0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2 WHO-GMP \u00b7 \u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u00b7 \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u00b7 1,400+ \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 <a href=\"https:\/\/medsbase.com\/el\/reviews\/\">\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\"><strong>\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n<h3>\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n<p>\u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n<h2 class=\"wp-block-heading\">What Is Hydrocl?<\/h2>\n<p>Hydrocl is an oral 12.5 \/ 25 mg hydrochlorothiazide tablet from a WHO-GMP certified manufacturer, supplied in 30-180 tablets. Hydrochlorothiazide was introduced in 1959 by Merck Sharp &amp; Dohme as <strong>HydroDiuril<\/strong> &mdash; derived from sulfanilamide during the sulfonamide-antibiotic programme when its diuretic activity was noticed serendipitously. HCTZ became the reference thiazide and has been a first-line antihypertensive ever since.<\/p>\n<h2 class=\"wp-block-heading\">How Hydrochlorothiazide Works<\/h2>\n<p>Hydrochlorothiazide inhibits the <strong>NCC (sodium-chloride cotransporter) in the distal convoluted tubule<\/strong>. \u039f\u03b9 \u03b5\u03c0\u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03b5\u03c2 \u03b5\u03c0\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2:<\/p>\n<ul>\n<li><strong>Reduced sodium reabsorption<\/strong> in the distal convoluted tubule &mdash; a modest (~5%) increase in urinary sodium excretion<\/li>\n<li><strong>Volume contraction<\/strong> over the first 1-2 weeks &mdash; this is the dominant early BP-lowering mechanism<\/li>\n<li><strong>\u0386\u03bc\u03b5\u03c3\u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03b3\u03b3\u03b5\u03b9\u03bf\u03b4\u03b9\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong> developing over 2-6 weeks &mdash; the dominant long-term BP mechanism; thiazides at steady state reduce systemic vascular resistance independent of continued volume contraction<\/li>\n<li><strong>Enhanced distal-tubule calcium reabsorption<\/strong> &mdash; modestly raises serum calcium and reduces urinary calcium (exploited in calcium stone prevention)<\/li>\n<li><strong>Reduced free water clearance<\/strong> &mdash; can cause hyponatraemia in susceptible patients<\/li>\n<li><strong>Activation of the renin-angiotensin-aldosterone system<\/strong> as a compensatory response &mdash; partially blunts the BP effect of monotherapy; neutralised by combining with an ARB or ACE inhibitor (the rationale for FDCs like <a href=\"https:\/\/medsbase.com\/el\/telma-h\/\">Telma H<\/a>, <a href=\"https:\/\/medsbase.com\/el\/cosart-h\/\">Cosart H<\/a>)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u0395\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9 \u0392\u03b1\u03c3\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c3\u03b5 \u0391\u03c0\u03bf\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03a7\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li><strong>Hypertension (first-line; guideline-recommended alongside ARB, ACEi, and CCB)<\/strong> \u2014 \u03ba\u03cd\u03c1\u03b9\u03b1 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9<\/li>\n<li><strong>Mild heart failure oedema<\/strong> &mdash; step up to loop diuretic if not controlled<\/li>\n<li><strong>Recurrent calcium-containing kidney stones<\/strong> &mdash; 12.5-25 mg reduces calcium excretion and stone recurrence by 30-50%<\/li>\n<li><strong>Nephrogenic diabetes insipidus<\/strong> &mdash; paradoxical reduction in urine output at 25 mg BD<\/li>\n<li><strong>Osteoporosis<\/strong> &mdash; modest benefit via reduced urinary calcium loss (adjunctive only)<\/li>\n<\/ul>\n<p><strong>\u039a\u03c5\u03c1\u03af\u03b1\u03c1\u03c7\u03b5\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2:<\/strong> <strong>ALLHAT (2002)<\/strong> &mdash; chlorthalidone (a close thiazide analogue) non-inferior to amlodipine and lisinopril for fatal and nonfatal cardiovascular endpoints in &gt;33,000 hypertensive patients; cemented thiazides as a first-line option. <strong>SHEP (1991)<\/strong> &mdash; chlorthalidone-based therapy reduced stroke by 36% in isolated systolic hypertension of the elderly. <strong>MRFIT, HDFP<\/strong> (1970s-80s) &mdash; earlier evidence base. HCTZ-specific large-scale hard-outcome data is weaker than chlorthalidone&rsquo;s but class effect is presumed.<\/p>\n<h2 class=\"wp-block-heading\">Hydrocl Dosage<\/h2>\n<p><strong>\u0394\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7:<\/strong> Start 12.5 mg once daily in the morning. Target 12.5-25 mg. <strong>Do not exceed 25 mg<\/strong> for hypertension &mdash; higher doses give diminishing returns on BP but worsen metabolic side effects (urate, glucose, lipids). Modern guidelines have moved away from the historical 50 mg antihypertensive dose.<\/p>\n<p><strong>\u0386\u03bb\u03bb\u03b5\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2:<\/strong> <strong>Mild heart failure oedema:<\/strong> 25-50 mg\/day; escalate to loop diuretic (furosemide) if not controlled. <strong>Idiopathic hypercalciuria (recurrent calcium stones):<\/strong> 12.5-25 mg\/day &mdash; thiazides promote distal-tubule calcium reabsorption and reduce stone recurrence by 30-50%. <strong>Nephrogenic diabetes insipidus:<\/strong> 25 mg twice daily paradoxically reduces urine output.<\/p>\n<p><strong>\u03a7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7:<\/strong> \u03bc\u03af\u03b1 \u03c6\u03bf\u03c1\u03ac \u03c4\u03b7\u03bd \u03b7\u03bc\u03ad\u03c1\u03b1 (\u03ae \u03b4\u03cd\u03bf \u03c6\u03bf\u03c1\u03ad\u03c2 \u03c4\u03b7\u03bd \u03b7\u03bc\u03ad\u03c1\u03b1 \u03b3\u03b9\u03b1 \u03c5\u03c8\u03b7\u03bb\u03ad\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03b8\u03b7\u03bb\u03b1\u03ba\u03b9\u03ba\u03ce\u03bd \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03c3\u03b5 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1), \u03c4\u03bf \u03c0\u03c1\u03c9\u03af. \u0397 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03bf \u03b2\u03c1\u03ac\u03b4\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03bd\u03c5\u03ba\u03c4\u03bf\u03c5\u03c1\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c6\u03b5\u03cd\u03b3\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03bd. \u039b\u03ae\u03c8\u03b7 \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03ce\u03c1\u03b1 \u03ba\u03ac\u03b8\u03b5 \u03bc\u03ad\u03c1\u03b1. \u0397 \u03c4\u03c1\u03bf\u03c6\u03ae \u03b4\u03b5\u03bd \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03ba\u03b1\u03bd\u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03ac \u03c4\u03b1 \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac.<\/p>\n<p><strong>\u03a0\u03c1\u03cc\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2:<\/strong><\/p>\n<ul>\n<li><strong>\u0392\u03b1\u03c3\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7:<\/strong> \u03bf\u03c5\u03c1\u03af\u03b1, \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03bb\u03cd\u03c4\u03b5\u03c2 (\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03ba\u03ac\u03bb\u03b9\u03bf \u03ba\u03b1\u03b9 \u03bd\u03ac\u03c4\u03c1\u03b9\u03bf), \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7, eGFR, \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7, \u03bf\u03c5\u03c1\u03b9\u03ba\u03cc \u03bf\u03be\u03cd \u03bf\u03c1\u03bf\u03cd. \u039f\u03b9\u03ba\u03b9\u03b1\u03ba\u03ae \u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03af\u03b5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03cc \u03b2\u03ac\u03c1\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1.<\/li>\n<li><strong>1-2 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03ae \u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03b4\u03cc\u03c3\u03b7\u03c2:<\/strong> \u03b5\u03c0\u03b1\u03bd\u03b1\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03cc\u03bc\u03b5\u03bd\u03b7 U&amp;E \u03ba\u03b1\u03b9 \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7. \u0391\u03bd\u03b1\u03bc\u03ad\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ae\u03c0\u03b9\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03c4\u03c9\u03bd \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03bb\u03c5\u03c4\u03ce\u03bd\u00b7 \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bb\u03bb\u03b1\u03b3\u03ce\u03bd.<\/li>\n<li><strong>4-6 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2:<\/strong> \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03ae\u03c1\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb.<\/li>\n<li><strong>\u03a3\u03c5\u03bd\u03b5\u03c7\u03ae\u03c2 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7:<\/strong> \u03b5\u03c4\u03ae\u03c3\u03b9\u03b1 U&amp;E, \u03bf\u03c5\u03c1\u03b9\u03ba\u03cc \u03bf\u03be\u03cd, \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7 \u03ba\u03b1\u03b9 \u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03af\u03bf \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03bc\u03cc\u03bb\u03b9\u03c2 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af. \u03a0\u03b9\u03bf \u03c3\u03c5\u03c7\u03bd\u03ac \u03c3\u03b5 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf, \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03ae \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1.<\/li>\n<li><strong>\u0394\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03b4\u03cc\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7:<\/strong> \u03bd\u03ac\u03c4\u03c1\u03b9\u03bf &lt;130 \u03bc\u03b5 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1, \u03ba\u03ac\u03bb\u03b9\u03bf 5.5, \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7\u03c2 &gt;30%, \u03bd\u03b5\u03b1\u03c1\u03ae \u03bf\u03c5\u03c1\u03b9\u03ba\u03ae \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1, \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae\u03c2 \u03b1\u03c6\u03c5\u03b4\u03ac\u03c4\u03c9\u03c3\u03b7\u03c2.<\/li>\n<\/ul>\n<p><strong>\u0394\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae:<\/strong> \u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7\u03c2 \u03b1\u03bb\u03bb\u03ac \u03b7 \u03b1\u03c0\u03cc\u03c4\u03bf\u03bc\u03b7 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03b5\u03b9 \u03b1\u03bd\u03ac\u03ba\u03b1\u03bc\u03c8\u03b7 \u03cc\u03b3\u03ba\u03bf\u03c5 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c3\u03b5 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c5\u03c8\u03b7\u03bb\u03ae \u03b4\u03cc\u03c3\u03b7 \u03b8\u03b7\u03bb\u03b1\u03ba\u03b9\u03ba\u03ce\u03bd \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u2014 \u03c3\u03c4\u03b1\u03b4\u03b9\u03b1\u03ba\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03cc\u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03bd \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2.<\/p>\n<ul>\n<li><strong>Loses efficacy at eGFR &lt;30.<\/strong> Switch to a loop diuretic (furosemide, torasemide) at advanced CKD &mdash; thiazides need functioning distal-tubule sodium delivery.<\/li>\n<li><strong>Raises serum calcium<\/strong> (paradoxical: thiazides enhance distal calcium reabsorption). Useful in osteoporotic patients; problematic in hypercalcaemic conditions (primary hyperparathyroidism, sarcoidosis).<\/li>\n<li><strong>\u0395\u03be\u03ac\u03bd\u03b8\u03b7\u03bc\u03b1 \u03c6\u03c9\u03c4\u03bf\u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1\u03c2<\/strong> is a specific thiazide class effect &mdash; counsel sun protection in sunny regions.<\/li>\n<li><strong>Sulfonamide cross-reactivity<\/strong> &mdash; avoid if severe sulfa allergy (rare; non-antibiotic sulfonamides rarely cross-react).<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/h2>\n<p><strong>\u03a3\u03c5\u03c7\u03bd\u03ac (&gt;1%):<\/strong><\/p>\n<ul>\n<li><strong>\u03a5\u03c0\u03bf\u03ba\u03b1\u03bb\u03b9\u03b1\u03b9\u03bc\u03af\u03b1<\/strong> (3-5%) &mdash; more common at doses &gt;25 mg; largely prevented when combined with an ACEi\/ARB<\/li>\n<li><strong>\u03a5\u03c0\u03bf\u03bd\u03b1\u03c4\u03c1\u03b9\u03b1\u03b9\u03bc\u03af\u03b1<\/strong> (2-5%) &mdash; especially in elderly women on low-salt diets; can be severe<\/li>\n<li><strong>\u03a5\u03c0\u03b5\u03c1\u03bf\u03c5\u03c1\u03b9\u03c7\u03b1\u03b9\u03bc\u03af\u03b1<\/strong> and gout precipitation<\/li>\n<li><strong>Modest worsening of glucose tolerance<\/strong> (fasting glucose +5-8 mg\/dL average)<\/li>\n<li><strong>Mild LDL and triglyceride rise<\/strong><\/li>\n<li><strong>\u0391\u03bd\u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03c4\u03cd\u03c3\u03b7\u03c2<\/strong> in some men &mdash; dose-related<\/li>\n<li><strong>\u03a5\u03c0\u03b5\u03c1\u03ba\u03b1\u03bb\u03c3\u03b9\u03bd\u03b1\u03b9\u03bc\u03af\u03b1<\/strong> (usually mild)<\/li>\n<li><strong>\u0395\u03be\u03ac\u03bd\u03b8\u03b7\u03bc\u03b1 \u03c6\u03c9\u03c4\u03bf\u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1\u03c2<\/strong><\/li>\n<\/ul>\n<p><strong>\u03a3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b1\u03bb\u03bb\u03ac \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac:<\/strong><\/p>\n<ul>\n<li><strong>\u03a3\u03bf\u03b2\u03b1\u03c1\u03ae \u03c5\u03c0\u03bf\u03bd\u03b1\u03c4\u03c1\u03b9\u03b1\u03b9\u03bc\u03af\u03b1<\/strong> \u2014 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03bc\u03b5 \u03b4\u03af\u03b1\u03b9\u03c4\u03b1 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ae\u03c2 \u03b1\u03bb\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2, \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03bc\u03b5 \u03c4\u03ac\u03c3\u03b7 \u03b3\u03b9\u03b1 SIADH \u03ae \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 SSRIs. \u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03ba\u03b4\u03b7\u03bb\u03c9\u03b8\u03b5\u03af \u03c9\u03c2 \u03c3\u03cd\u03b3\u03c7\u03c5\u03c3\u03b7, \u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03ae \u03c3\u03c0\u03b1\u03c3\u03bc\u03bf\u03af.<\/li>\n<li><strong>\u03a0\u03b1\u03b3\u03ba\u03c1\u03b5\u03b1\u03c4\u03af\u03c4\u03b9\u03b4\u03b1<\/strong> \u2014 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03ba\u03bb\u03ac\u03c3\u03b7\u03c2 \u03b8\u03b5\u03b9\u03b1\u03b6\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd\/\u03b2\u03c1\u03cc\u03b3\u03c7\u03c9\u03bd\u00b7 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03ac\u03bc\u03b5\u03c3\u03b1 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03ac\u03bd\u03c9 \u03ba\u03bf\u03b9\u03bb\u03b9\u03b1\u03ba\u03bf\u03cd \u03c0\u03cc\u03bd\u03bf\u03c5 \u03bc\u03b5 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03bb\u03b9\u03c0\u03ac\u03c3\u03b7\u03c2<\/li>\n<li><strong>\u0398\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c0\u03b5\u03bd\u03af\u03b1, \u03bb\u03b5\u03c5\u03ba\u03bf\u03c0\u03b5\u03bd\u03af\u03b1, \u03b1\u03b3\u03ba\u03c1\u03b1\u03bd\u03bf\u03c5\u03bb\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03c3\u03b7<\/strong> \u2014 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b5\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 (\u03c0\u03b9\u03bf \u03c3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03bc\u03b5 \u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b9\u03b1 \u03c0\u03b1\u03c1\u03ac \u03bc\u03b5 \u03b2\u03c1\u03cc\u03b3\u03c7\u03bf\u03c5\u03c2)<\/li>\n<li><strong>\u039f\u03be\u03b5\u03af\u03b1 \u03bc\u03c5\u03c9\u03c0\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b3\u03bb\u03b1\u03cd\u03ba\u03c9\u03bc\u03b1 \u03ba\u03bb\u03b5\u03b9\u03c3\u03c4\u03ae\u03c2 \u03b3\u03c9\u03bd\u03af\u03b1\u03c2<\/strong> \u2014 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b1\u03bd\u03c4\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03ba\u03bb\u03ac\u03c3\u03b7\u03c2 \u03c3\u03bf\u03c5\u03bb\u03c6\u03bf\u03bd\u03b1\u03bc\u03b9\u03b4\u03ce\u03bd \u03b5\u03bd\u03c4\u03cc\u03c2 \u03c9\u03c1\u03ce\u03bd \u03ae \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7\u00b7 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03ac\u03bc\u03b5\u03c3\u03b1 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03be\u03b1\u03c6\u03bd\u03b9\u03ba\u03bf\u03cd \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03bf\u03cd \u03c0\u03cc\u03bd\u03bf\u03c5 \u03ae \u03b1\u03bb\u03bb\u03b1\u03b3\u03ae\u03c2 \u03cc\u03c1\u03b1\u03c3\u03b7\u03c2<\/li>\n<li><strong>\u03a3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Stevens-Johnson \/ \u03c4\u03bf\u03be\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae \u03bd\u03b5\u03ba\u03c1\u03cc\u03bb\u03c5\u03c3\u03b7<\/strong> \u2014 \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03c3\u03c0\u03ac\u03bd\u03b9\u03bf \u03b1\u03bb\u03bb\u03ac \u03ad\u03c7\u03b5\u03b9 \u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03b8\u03b5\u03af<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u0391\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li>Anuria or severe renal impairment (eGFR &lt;30) &mdash; loses efficacy<\/li>\n<li>Sulfonamide (sulfa) hypersensitivity<\/li>\n<li>Symptomatic hyponatraemia (Na &lt;130) or hypokalaemia (K &lt;3.0) at baseline<\/li>\n<li>\u03a5\u03c0\u03b5\u03c1\u03ba\u03b1\u03bb\u03c3\u03b9\u03bd\u03b1\u03b9\u03bc\u03af\u03b1<\/li>\n<li>\u03a3\u03bf\u03b2\u03b1\u03c1\u03ae \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 (Child-Pugh C)<\/li>\n<li>Addison disease (primary adrenal insufficiency)<\/li>\n<\/ul>\n<p><strong>\u0395\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7:<\/strong> \u03b3\u03b5\u03bd\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c6\u03b5\u03cd\u03b3\u03bf\u03bd\u03c4\u03b1\u03b9 \u2014 \u03bf\u03b9 \u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b5\u03c2 \u03b4\u03b9\u03b1\u03c3\u03c7\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03c0\u03bb\u03b1\u03ba\u03bf\u03cd\u03bd\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03bf\u03c5\u03bd \u03bd\u03b5\u03bf\u03b3\u03bd\u03b9\u03ba\u03ae \u03af\u03ba\u03c4\u03b5\u03c1\u03bf \u03ae \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03c0\u03b5\u03bd\u03af\u03b1. \u03a7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c3\u03c4\u03b5 \u03bc\u03cc\u03bd\u03bf \u03b5\u03ac\u03bd \u03c4\u03bf \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03c5\u03c0\u03b5\u03c1\u03c4\u03b5\u03c1\u03b5\u03af \u03c3\u03b1\u03c6\u03ce\u03c2 \u03c4\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 (\u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 \u03c3\u03b5 \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7), \u03c5\u03c0\u03cc \u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03c6\u03c1\u03bf\u03bd\u03c4\u03af\u03b4\u03b1.<\/p>\n<p><strong>\u0398\u03b7\u03bb\u03b1\u03c3\u03bc\u03cc\u03c2:<\/strong> \u03b3\u03b5\u03bd\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03c3\u03b5 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ad\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2\u00b7 \u03bf\u03b9 \u03c5\u03c8\u03b7\u03bb\u03ad\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b5\u03af\u03bb\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b3\u03b1\u03bb\u03bf\u03c5\u03c7\u03af\u03b1 (\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03bf\u03b9 \u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b5\u03c2). \u03a0\u03c1\u03bf\u03c4\u03b9\u03bc\u03ce\u03bd\u03c4\u03b1\u03b9 \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03ac (\u03c0\u03c1\u03bf\u03c0\u03c1\u03b1\u03bd\u03cc\u03bb\u03bf\u03bb, \u03bd\u03b9\u03c6\u03b5\u03b4\u03b9\u03c0\u03af\u03bd\u03b7) \u03cc\u03c4\u03b1\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03bd.<\/p>\n<h2 class=\"wp-block-heading\">\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03a6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd<\/h2>\n<ul>\n<li><strong>\u039b\u03af\u03b8\u03b9\u03bf \u2014 \u039a\u03a1\u0399\u03a3\u0399\u039c\u0397 \u0391\u039b\u039b\u0397\u039b\u0395\u03a0\u0399\u0394\u03a1\u0391\u03a3\u0397.<\/strong> \u039f\u03b9 \u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03bf\u03af \u03b2\u03c1\u03cc\u03b3\u03c7\u03bf\u03c5 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03ba\u03ac\u03b8\u03b1\u03c1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bb\u03b9\u03b8\u03af\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03bf\u03c5\u03bd \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bb\u03b9\u03b8\u03af\u03bf\u03c5. \u0391\u03c0\u03bf\u03c6\u03cd\u03b3\u03b5\u03c4\u03b5 \u03c4\u03bf\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03b5\u03ac\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03bd\u00b7 \u03b5\u03ac\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c0\u03cc\u03c6\u03b5\u03c5\u03ba\u03c4\u03bf\u03c2, \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03ae\u03c3\u03c4\u03b5 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03bb\u03b9\u03b8\u03af\u03bf\u03c5 \u03b5\u03b2\u03b4\u03bf\u03bc\u03b1\u03b4\u03b9\u03b1\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03c0\u03c1\u03ce\u03c4\u03bf \u03bc\u03ae\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b9\u03ce\u03c3\u03c4\u03b5 \u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03bb\u03b9\u03b8\u03af\u03bf\u03c5 \u03ba\u03b1\u03c4\u03ac 25-50%.<\/li>\n<li><strong>\u039c\u03b7 \u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ae \u03b1\u03bd\u03c4\u03b9\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 (NSAIDs)<\/strong> \u2014 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 (\u03bc\u03ad\u03c3\u03c9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03b3\u03bb\u03b1\u03bd\u03b4\u03b9\u03bd\u03ce\u03bd) \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03bf\u03be\u03b5\u03af\u03b1\u03c2 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b2\u03bb\u03ac\u03b2\u03b7\u03c2 \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 ACEi\/ARB (\u03c4\u03bf \u201c\u03c4\u03c1\u03b9\u03c0\u03bb\u03cc \u03c7\u03c4\u03cd\u03c0\u03b7\u03bc\u03b1\u201d). \u03a7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b5 \u03c0\u03c1\u03bf\u03c4\u03b9\u03bc\u03b7\u03c3\u03b9\u03b1\u03ba\u03ac \u03c0\u03b1\u03c1\u03b1\u03ba\u03b5\u03c4\u03b1\u03bc\u03cc\u03bb\u03b7 \u03b3\u03b9\u03b1 \u03c7\u03c1\u03cc\u03bd\u03b9\u03bf \u03c0\u03cc\u03bd\u03bf.<\/li>\n<li><strong>\u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 ACE \u03ba\u03b1\u03b9 ARBs<\/strong> \u2014 \u03bf \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c4\u03ac\u03bd\u03c4\u03b1\u03c1\u03c4 \u03ba\u03b1\u03b9 \u03c9\u03c6\u03ad\u03bb\u03b9\u03bc\u03bf\u03c2 \u03c3\u03c4\u03b7\u03bd \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7\u00b7 \u03b7 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 ACEi\/ARB \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03b1\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 RAAS \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7. \u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03ae\u03c3\u03c4\u03b5 \u03ba\u03ac\u03bb\u03b9\u03bf \u03ba\u03b1\u03b9 \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7.<\/li>\n<li><strong>\u03a0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b5\u03c2 \u03ba\u03b1\u03bb\u03af\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03c0\u03bf\u03c5 \u03b5\u03be\u03bf\u03b9\u03ba\u03bf\u03bd\u03bf\u03bc\u03bf\u03cd\u03bd \u03ba\u03ac\u03bb\u03b9\u03bf<\/strong> \u2014 \u03c3\u03c5\u03c7\u03bd\u03ac \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03b1\u03b8\u03bc\u03b9\u03c3\u03c4\u03b5\u03af \u03b7 \u03c5\u03c0\u03bf\u03ba\u03b1\u03bb\u03b9\u03b1\u03b9\u03bc\u03af\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03b2\u03c1\u03cc\u03b3\u03c7\u03bf\u03c5\/\u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b5\u03c2. \u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03ae\u03c3\u03c4\u03b5 \u03c4\u03bf \u03ba\u03ac\u03bb\u03b9\u03bf\u00b7 \u03b1\u03c0\u03bf\u03c6\u03cd\u03b3\u03b5\u03c4\u03b5 \u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7.<\/li>\n<li><strong>\u039d\u03c4\u03b9\u03b3\u03ba\u03bf\u03be\u03af\u03bd\u03b7<\/strong> \u2014 \u03b7 \u03c5\u03c0\u03bf\u03ba\u03b1\u03bb\u03b9\u03b1\u03b9\u03bc\u03af\u03b1 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b4\u03b9\u03b3\u03bf\u03be\u03af\u03bd\u03b7\u03c2 (\u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03b2\u03c1\u03cc\u03b3\u03c7\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b5\u03c2)\u00b7 \u03b7 \u03c3\u03c0\u03b9\u03c1\u03bf\u03bd\u03bf\u03bb\u03b1\u03ba\u03c4\u03cc\u03bd\u03b7 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03ac\u03bc\u03b5\u03c3\u03b1 \u03c4\u03b7\u03bd \u03ba\u03ac\u03b8\u03b1\u03c1\u03c3\u03b7 \u03b4\u03b9\u03b3\u03bf\u03be\u03af\u03bd\u03b7\u03c2. \u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03ae\u03c3\u03c4\u03b5 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b4\u03b9\u03b3\u03bf\u03be\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03bb\u03af\u03bf\u03c5 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03ae \u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd.<\/li>\n<li><strong>\u03a3\u03c4\u03bf\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03af \u03ba\u03bf\u03c1\u03c4\u03b9\u03ba\u03bf\u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03b5\u03af\u03c2, \u03b1\u03bc\u03c6\u03bf\u03c4\u03b5\u03c1\u03b9\u03ba\u03af\u03bd\u03b7 \u0392, \u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b8\u03b1\u03c1\u03c4\u03b9\u03ba\u03ac<\/strong> \u2014 \u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b7 \u03c5\u03c0\u03bf\u03ba\u03b1\u03bb\u03b9\u03b1\u03b9\u03bc\u03af\u03b1 (\u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03b2\u03c1\u03cc\u03b3\u03c7\u03bf\u03c5\/\u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b5\u03c2) \u03ae \u03ba\u03c1\u03c5\u03bc\u03bc\u03ad\u03bd\u03b7 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03b3\u03b9\u03b1 \u03ba\u03ac\u03bb\u03b9\u03bf (\u03c3\u03c0\u03b9\u03c1\u03bf\u03bd\u03bf\u03bb\u03b1\u03ba\u03c4\u03cc\u03bd\u03b7).<\/li>\n<li><strong>\u03a3\u03c4\u03bf\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03b4\u03b9\u03b1\u03b2\u03b7\u03c4\u03b9\u03ba\u03ac \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1, \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7<\/strong> \u2014 \u03bf\u03b9 \u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b5\u03c2 \u03ba\u03b1\u03b9 (\u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf) \u03c4\u03b1 \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03b2\u03c1\u03cc\u03b3\u03c7\u03bf\u03c5 \u03b5\u03c0\u03b9\u03b4\u03b5\u03b9\u03bd\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c7\u03ae \u03c3\u03c4\u03b7 \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7\u00b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ad\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2.<\/li>\n<li><strong>\u03a7\u03bf\u03bb\u03b7\u03c3\u03c4\u03c5\u03c1\u03b1\u03bc\u03af\u03bd\u03b7 \/ \u03ba\u03bf\u03bb\u03b5\u03c3\u03c4\u03b9\u03c0\u03cc\u03bb\u03b7<\/strong> \u2014 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b8\u03b5\u03b9\u03b1\u03b6\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03b8\u03b7\u03bb\u03c5\u03ba\u03c9\u03b4\u03ce\u03bd \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03c4\u03ac 40-85%. \u03a7\u03c9\u03c1\u03af\u03c3\u03c4\u03b5 \u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03ba\u03ac\u03b8\u03b5 4 \u03ce\u03c1\u03b5\u03c2.<\/li>\n<li><strong>\u0391\u03bb\u03ba\u03bf\u03cc\u03bb<\/strong> \u2014 \u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b7 \u03bf\u03c1\u03b8\u03bf\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ae \u03c5\u03c0\u03cc\u03c4\u03b1\u03c3\u03b7.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Where Hydrocl Fits in the Diuretic Class<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u039a\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u0395\u03ba\u03c0\u03c1\u03cc\u03c3\u03c9\u03c0\u03bf\u03b9<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u03a4\u03c5\u03c0\u03b9\u03ba\u03ae \u03c7\u03c1\u03ae\u03c3\u03b7<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff3cd;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0398\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b9\u03bf<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><a href=\"https:\/\/medsbase.com\/el\/aquazide\/\">HCTZ<\/a>, \u03c7\u03bb\u03bf\u03c1\u03b8\u03b1\u03bb\u03b9\u03b4\u03cc\u03bd\u03b7<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u03a0\u03c1\u03ce\u03c4\u03b7 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae \u03b3\u03b9\u03b1 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7, \u03c0\u03ad\u03c4\u03c1\u03b5\u03c2 \u03bd\u03b5\u03c6\u03c1\u03ce\u03bd, \u03bd\u03b5\u03c6\u03c1\u03bf\u03b3\u03b5\u03bd\u03ae \u0394\u0399<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0398\u03b5\u03b9\u03b1\u03b6\u03b9\u03b4\u03b9\u03ba\u03cc<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><a href=\"https:\/\/medsbase.com\/el\/natrilix-sr\/\">\u0399\u03bd\u03b4\u03b1\u03c0\u03b1\u03bc\u03af\u03b4\u03b7<\/a>, \u03bc\u03b5\u03c4\u03bf\u03bb\u03b1\u03b6\u03cc\u03bd\u03b7<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u03a5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 (\u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03b9, \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 HYVET), \u03b4\u03b9\u03b1\u03b4\u03bf\u03c7\u03b9\u03ba\u03ae \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03bc\u03cc\u03c2<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0392\u03c1\u03cc\u03b3\u03c7\u03bf\u03c2 (\u03b2\u03c1\u03b1\u03c7\u03cd\u03b2\u03b9\u03bf\u03c2)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><a href=\"https:\/\/medsbase.com\/el\/lasix\/\">\u03a6\u03bf\u03c5\u03c1\u03bf\u03c3\u03b5\u03bc\u03af\u03b4\u03b7<\/a>, \u03b2\u03bf\u03c5\u03bc\u03b5\u03c4\u03b1\u03bd\u03af\u03b4\u03b7<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u039f\u03be\u03cd \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03cc \u03bf\u03af\u03b4\u03b7\u03bc\u03b1, \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1, \u03b1\u03c3\u03ba\u03af\u03c4\u03b7\u03c2, \u03c5\u03c0\u03b5\u03c1\u03ba\u03b1\u03bb\u03b9\u03b1\u03b9\u03bc\u03af\u03b1<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0392\u03c1\u03cc\u03b3\u03c7\u03bf\u03c2 (\u03bc\u03b1\u03ba\u03c1\u03cc\u03b2\u03b9\u03bf\u03c2)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><a href=\"https:\/\/medsbase.com\/el\/dytor\/\">\u03a4\u03bf\u03c1\u03b1\u03c3\u03b5\u03bc\u03af\u03b4\u03b7<\/a><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u03a7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1, \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 (\u03bc\u03cc\u03bd\u03bf \u03b2\u03c1\u03cc\u03b3\u03c7\u03bf\u03c2 \u03bc\u03b5 \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7\u03c2), \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03bc\u03b5 \u03bf\u03af\u03b4\u03b7\u03bc\u03b1<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0391\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ae\u03c2 \u03b1\u03bb\u03b4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><a href=\"https:\/\/medsbase.com\/el\/aldactone\/\">\u03a3\u03c0\u03b9\u03c1\u03bf\u03bd\u03bf\u03bb\u03b1\u03ba\u03c4\u03cc\u03bd\u03b7<\/a>, \u03b5\u03c0\u03bb\u03b5\u03c1\u03b5\u03bd\u03cc\u03bd\u03b7<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u039a\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03bc\u03b5 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf \u03ba\u03bb\u03ac\u03c3\u03bc\u03b1 \u03b5\u03be\u03ce\u03c3\u03b5\u03c9\u03c2 (RALES), \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 (PATHWAY-2), \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Conn, \u03ba\u03b9\u03c1\u03c1\u03c9\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b1\u03c3\u03ba\u03af\u03c4\u03b7\u03c2<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0386\u03bb\u03bb\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1 \u03ba\u03ac\u03bb\u03b9\u03bf<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0391\u03bc\u03b9\u03bb\u03bf\u03c1\u03af\u03b4\u03b7, \u03c4\u03c1\u03b9\u03b1\u03bc\u03c4\u03b5\u03c1\u03ad\u03bd\u03b7 (\u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03cd\u03c2)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u03a0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03c5\u03c0\u03bf\u03ba\u03b1\u03bb\u03b9\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 \u03cc\u03c4\u03b1\u03bd \u03c0\u03c1\u03bf\u03c3\u03c4\u03af\u03b8\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b2\u03c1\u03cc\u03b3\u03c7\u03bf\/\u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b9\u03bf<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0391\u03bd\u03b8\u03c1\u03b1\u03ba\u03b9\u03ba\u03ae \u03b1\u03bd\u03c5\u03b4\u03c1\u03ac\u03c3\u03b7<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0391\u03ba\u03b5\u03c4\u03b1\u03b6\u03bf\u03bb\u03b1\u03bc\u03af\u03b4\u03b7<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u03a5\u03c8\u03bf\u03c6\u03bf\u03b2\u03af\u03b1, \u03b3\u03bb\u03b1\u03cd\u03ba\u03c9\u03bc\u03b1, \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae \u03b1\u03bb\u03ba\u03ac\u03bb\u03c9\u03c3\u03b7<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7<\/h2>\n<p>Store Hydrocl below 25&deg;C in the original blister pack. Keep out of reach of children.<\/p>\n<h2 id=\"faqs\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3 class=\"wp-block-heading\">When should I take Hydrocl &mdash; morning or evening?<\/h3>\n<p><strong>\u03a0\u03c1\u03c9\u03af<\/strong> in almost all cases. The diuretic effect produces increased urine output for 2-4 hours after dosing. Evening dosing causes nocturia and disrupts sleep. Patients on twice-daily loop diuretics typically dose at breakfast and early afternoon (not bedtime).<\/p>\n<h3 class=\"wp-block-heading\">Is Hydrocl a first-line blood-pressure drug?<\/h3>\n<p>\u039d\u03b1\u03b9 \u2014 \u03bf\u03b9 \u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b5\u03c2 (HCTZ, \u03c7\u03bb\u03c9\u03c1\u03b8\u03b1\u03bb\u03b9\u03b4\u03cc\u03bd\u03b7) \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b5\u03c2 \u03bf\u03c5\u03c3\u03af\u03b5\u03c2 (\u03b9\u03bd\u03b4\u03b1\u03c0\u03b1\u03bc\u03af\u03b4\u03b7) \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03af\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 <strong>\u03c4\u03ad\u03c3\u03c3\u03b5\u03c1\u03b9\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03ce\u03bd \u03c0\u03c1\u03ce\u03c4\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2<\/strong> \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 \u03c4\u03bf\u03c5\u03c2 ARB, \u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 ACE \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03c9\u03bd \u03b1\u03b3\u03c9\u03b3\u03ce\u03bd \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5. \u0393\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5\u03c2 \u03bd\u03b5\u03bf\u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2, \u03bc\u03b9\u03b1 \u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c0\u03c1\u03ce\u03c4\u03bf \u03ae \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf, \u03ba\u03b1\u03b9 \u03c3\u03c7\u03b5\u03b4\u03cc\u03bd \u03cc\u03bb\u03bf\u03b9 \u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c3\u03b5 \u03c0\u03bf\u03bb\u03c5\u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03bc\u03af\u03b1.<\/p>\n<h3 class=\"wp-block-heading\">Will Hydrocl affect my potassium?<\/h3>\n<p>Yes &mdash; Hydrocl <strong>\u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9<\/strong> \u03c4\u03bf \u03ba\u03ac\u03bb\u03b9\u03bf \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03ba\u03b1\u03bb\u03af\u03bf\u03c5 \u03c3\u03c4\u03bf\u03bd \u03bc\u03b1\u03ba\u03c1\u03b9\u03bd\u03cc \u03c3\u03c9\u03bb\u03ae\u03bd\u03b1. \u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03ae\u03c3\u03c4\u03b5 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c1\u03c7\u03ae, \u03c3\u03b5 1-2 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03bf\u03b4\u03b9\u03ba\u03ac. \u039f \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03c5\u03c0\u03bf\u03ba\u03b1\u03bb\u03b9\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 <strong>\u03b5\u03bb\u03b1\u03c7\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc<\/strong> Hydrocl with an ARB or ACE inhibitor &mdash; which is the standard combination in hypertension anyway. If potassium drops below 3.5 in isolated diuretic use, add potassium supplementation, a potassium-rich diet, or a small dose of a potassium-sparing agent (spironolactone, eplerenone, or an <a href=\"https:\/\/medsbase.com\/el\/amifru\/\">\u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 \u03b1\u03bc\u03b9\u03bb\u03bf\u03c1\u03af\u03b4\u03b7<\/a>).<\/p>\n<h3 class=\"wp-block-heading\">I have gout &mdash; can I take Hydrocl?<\/h3>\n<p>\u039c\u03b5 \u03c0\u03c1\u03bf\u03c3\u03bf\u03c7\u03ae. \u03a4\u03b1 \u03b8\u03b5\u03b9\u03b1\u03b6\u03b9\u03b4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 (\u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf) \u03c4\u03b1 \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03b2\u03c1\u03cc\u03c7\u03bf\u03c5 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf \u03bf\u03c5\u03c1\u03b9\u03ba\u03cc \u03bf\u03be\u03cd \u03c3\u03c4\u03bf \u03b1\u03af\u03bc\u03b1 \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b1 \u03c4\u03b7\u03bd \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03c4\u03bf \u03b5\u03b3\u03b3\u03cd\u03c2 \u03c3\u03c9\u03bb\u03b7\u03bd\u03b1\u03c1\u03af\u03bf. \u03a3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c4\u03ac\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03bf\u03c5\u03c1\u03b9\u03ba\u03ae \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1: \u03c0\u03c1\u03bf\u03c4\u03b9\u03bc\u03ae\u03c3\u03c4\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03cd\u03c2 \u03bc\u03b5 \u03bb\u03bf\u03b6\u03b1\u03c1\u03c4\u03ac\u03bd\u03b7 (<a href=\"https:\/\/medsbase.com\/el\/cosart-h\/\">Cosart H<\/a>, <a href=\"https:\/\/medsbase.com\/el\/cozartan-h\/\">Cozartan H<\/a>) whose losartan component is uniquely uricosuric and offsets the thiazide urate rise. If Hydrocl is already in use and gout flares, add or continue urate-lowering therapy (allopurinol) rather than stopping Hydrocl outright.<\/p>\n<h3 class=\"wp-block-heading\">I&rsquo;m diabetic &mdash; is Hydrocl safe?<\/h3>\n<p>Mostly yes, but be aware that thiazides and (to a lesser extent) loop diuretics <strong>modestly worsen glucose tolerance<\/strong> (average fasting glucose rise 5-8 mg\/dL, HbA1c 0.1-0.3%). The BP benefit outweighs this in most diabetics. If you want a more metabolically neutral combination, ARB+CCB is an alternative (<a href=\"https:\/\/medsbase.com\/el\/olmezest-am\/\">Olmezest AM<\/a>).<\/p>\n<h3 class=\"wp-block-heading\">Can I take ibuprofen with Hydrocl?<\/h3>\n<p>\u0397 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c4\u03b1\u03c3\u03b9\u03b1\u03ba\u03ae \u03b2\u03c1\u03b1\u03c7\u03c5\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b5\u03bd\u03c4\u03ac\u03be\u03b5\u03b9. \u0397 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b7\u03bc\u03b5\u03c1\u03ae\u03c3\u03b9\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b7 NSAIDs (\u03b9\u03b2\u03bf\u03c5\u03c0\u03c1\u03bf\u03c6\u03b1\u03af\u03bd\u03b7, \u03b4\u03b9\u03c7\u03bb\u03bf\u03c6\u03b1\u03b9\u03bd\u03ac\u03ba\u03b7, \u03bd\u03b1\u03c0\u03c1\u03bf\u03be\u03ad\u03bd\u03b7) <strong>\u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03bf \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/strong> of Hydrocl (prostaglandin blockade) and substantially raise the AKI risk when combined with an ACE inhibitor or ARB &mdash; the &#8220;triple whammy.&#8221; Use paracetamol preferentially for chronic pain.<\/p>\n<h3 class=\"wp-block-heading\">\u0398\u03b1 \u03bf\u03c5\u03c1\u03ce \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c4\u03b7 \u03bd\u03cd\u03c7\u03c4\u03b1;<\/h3>\n<p>Usually no, if you take Hydrocl in the morning. The diuretic effect peaks 2-4 hours after dosing and has mostly worn off by evening. Nocturia is a common complaint when patients switch to evening dosing; switch back to morning dosing and nocturia resolves within 1-3 days.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Hydrocl in pregnancy?<\/h3>\n<p>Routinely avoided. Thiazides cross the placenta and can affect the fetus. For hypertension in pregnancy, switch to <a href=\"https:\/\/medsbase.com\/el\/labebet\/\">\u03bb\u03b1\u03b2\u03b5\u03c4\u03b1\u03bb\u03cc\u03bb\u03b7<\/a>, \u03bc\u03b5\u03b8\u03c5ldopa \u03ae \u03bd\u03b9\u03c6\u03b5\u03b4\u03af\u03c0\u03b7. \u03a4\u03b1 \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7 \u03bc\u03cc\u03bd\u03bf \u03b3\u03b9\u03b1 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 (\u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03cc \u03bf\u03af\u03b4\u03b7\u03bc\u03b1, \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1) \u03c5\u03c0\u03cc \u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b2\u03bb\u03b5\u03c8\u03b7.<\/p>\n<h3 class=\"wp-block-heading\">\u03a4\u03b9 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03bd \u03c7\u03ac\u03c3\u03c9 \u03bc\u03b9\u03b1 \u03b4\u03cc\u03c3\u03b7;<\/h3>\n<p>\u03a0\u03ac\u03c1\u03c4\u03b5 \u03c4\u03bf \u03bc\u03cc\u03bb\u03b9\u03c2 \u03c4\u03bf \u03b8\u03c5\u03bc\u03b7\u03b8\u03b5\u03af\u03c4\u03b5, \u03b5\u03ba\u03c4\u03cc\u03c2 \u03b1\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c7\u03b5\u03b4\u03cc\u03bd \u03ce\u03c1\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03c3\u03b1\u03c2 \u2014 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c0\u03b1\u03c1\u03b1\u03bb\u03b5\u03af\u03c8\u03c4\u03b5 \u03c4\u03b7 \u03c7\u03b1\u03bc\u03ad\u03bd\u03b7 \u03b4\u03cc\u03c3\u03b7. \u039c\u03b7\u03bd \u03c0\u03ac\u03c1\u03b5\u03c4\u03b5 \u03b4\u03b9\u03c0\u03bb\u03ae \u03b4\u03cc\u03c3\u03b7. \u039c\u03af\u03b1 \u03bc\u03cc\u03bd\u03bf \u03c7\u03b1\u03bc\u03ad\u03bd\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03b4\u03b5\u03bd \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03bd \u03bc\u03b1\u03ba\u03c1\u03bf\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c4\u03b7\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2 \u03ae \u03c4\u03c9\u03bd \u03c5\u03b3\u03c1\u03ce\u03bd.<\/p>\n<h3 class=\"wp-block-heading\">Where can I buy Hydrocl online?<\/h3>\n<p>You can buy Hydrocl (12.5 \/ 25 mg hydrochlorothiazide, 30-180 tablets) from MedsBase with discreet packaging and worldwide shipping.<\/p>\n<h2 class=\"wp-block-heading\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u0391\u03bd\u03c4\u03b9\u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03ac &amp; \u0394\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/amifru\/\">Amifru \u2014 \u03a6\u03bf\u03c5\u03c1\u03bf\u03c3\u03b5\u03bc\u03af\u03b4\u03b7 + \u0391\u03bc\u03b9\u03bb\u03bf\u03c1\u03af\u03b4\u03b7 (\u03b2\u03c1\u03cc\u03c7\u03bf\u03c2 + \u03b5\u03be\u03bf\u03b9\u03ba\u03bf\u03bd\u03cc\u03bc\u03b7\u03c3\u03b7 \u039a)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/aquazide\/\">Aquazide &mdash; Hydrochlorothiazide (HCTZ) thiazide<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/cosart-h\/\">Cosart H &mdash; Losartan + HCTZ fixed combination<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/lasix\/\">Lasix \u2014 Furosemide 40 mg (loop)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/ramcor\/\">Ramcor &mdash; Ramipril (ACEi partner for diuretic)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/telma-h\/\">Telma H &mdash; Telmisartan + HCTZ fixed combination<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/high-blood-pressure-medication\/\"><strong>\u03a0\u03b5\u03c1\u03b9\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c3\u03b5 \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03a6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b3\u03b9\u03b1 \u03a5\u03c8\u03b7\u03bb\u03ae \u03a0\u03af\u03b5\u03c3\u03b7 \u0391\u03af\u03bc\u03b1\u03c4\u03bf\u03c2<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 \u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u0391\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u0395\u03c5\u03b8\u03cd\u03bd\u03b7\u03c2.<\/strong> \u0391\u03c5\u03c4\u03ae \u03b7 \u03c3\u03b5\u03bb\u03af\u03b4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b3\u03b9\u03b1 \u03b5\u03bd\u03b7\u03bc\u03b5\u03c1\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c3\u03ba\u03bf\u03c0\u03bf\u03cd\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03c4\u03b7\u03bd \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03ae \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1\u03bd \u03ba\u03b1\u03c4\u03b1\u03be\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b1\u03b3\u03b3\u03b5\u03bb\u03bc\u03b1\u03c4\u03af\u03b1 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2. \u0397 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7, \u03b7 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03b1\u03c1\u03c1\u03c5\u03b8\u03bc\u03af\u03b5\u03c2 \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7, \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03b4\u03cc\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc \u2014 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b5 \u03b2-\u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c5\u03c0\u03cc \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b2\u03bb\u03b5\u03c8\u03b7.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2<\/h3>\n<p>\u0386\u03bb\u03bb\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 \u03c3\u03b5 <strong>\u03a7\u03c1\u03cc\u03bd\u03b9\u03b5\u03c2 \u03a0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2<\/strong> \u03c0\u03bf\u03c5 \u03bf\u03b9 \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/betnesol-tab\/\">Betnesol Tab<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/glycomet-sr\/\">Glycomet SR<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/calaptin-40\/\">Calaptin 40<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/paracip\/\">Paracip<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/tenvir\/\">\u03a4\u03b5\u03bd\u03b2\u03b9\u03c1<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Hydrocl is hydrochlorothiazide 12.5\/25 mg tablets \u2014 thiazide diuretic, first-line antihypertensive alongside ARB, ACEi, and CCB classes. Also used for mild heart-failure oedema, recurrent calcium kidney stone prevention (reduces stone recurrence 30-50%), and nephrogenic diabetes insipidus. Modern guidelines prefer 12.5-25 mg doses. Typically combined with an ARB or ACE inhibitor (e.g. Telma H, Cosart H).<\/p>","protected":false},"featured_media":57300,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3260,3356],"product_tag":[3401,4284],"class_list":{"0":"post-57299","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-heart-blood-pressure","9":"product_cat-high-blood-pressure-medication","10":"product_tag-hydrochlorothiazide","11":"product_tag-hydrocl","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/57299","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=57299"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/57300"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=57299"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=57299"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=57299"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=57299"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}