{"id":57719,"date":"2024-02-27T17:57:19","date_gmt":"2024-02-27T17:57:19","guid":{"rendered":"https:\/\/medsname.com\/itrotab\/"},"modified":"2026-04-30T10:24:23","modified_gmt":"2026-04-30T10:24:23","slug":"itrotab","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/itrotab\/","title":{"rendered":"Itrotab"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 20px;margin:18px 0;border-radius:6px;\">\n<h3 style=\"margin-top:0;\">\ud83d\udca1 \u0393\u03c1\u03ae\u03b3\u03bf\u03c1\u03b7 \u0391\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7<\/h3>\n<p style=\"margin-bottom:0;\">Itrotab is itraconazole 100 mg \/ 200 mg oral tablet \u2014 a triazole antifungal for dermatophyte nail and skin infections, oropharyngeal\/oesophageal candidiasis, histoplasmosis, blastomycosis, and aspergillosis (alternative to voriconazole). Capsule absorption requires gastric acid \u2014 take with food and acidic drink; PPIs and H2-blockers reduce absorption substantially. Strong CYP3A4 inhibitor \u2014 many drug interactions. Mandatory ECG \/ heart-failure screening \u2014 itraconazole has a negative inotropic effect.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f5f5;border:1px solid #e1e1e1;padding:18px 22px;margin:24px 0;border-radius:8px;display:flex;flex-wrap:wrap;justify-content:space-around;gap:16px;align-items:center;font-size:0.95em;\">\n<div style=\"text-align:center;flex:1;min-width:140px;\">\ud83c\udfed<br \/><strong>WHO-GMP<\/strong><br \/>certified manufacturer<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\"><strong>\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n<h3>\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n<p>\u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n<div style=\"text-align:center;flex:1;min-width:140px;\">\ud83d\udce6<br \/><strong>\u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1<\/strong><br \/>plain envelope<\/div>\n<div style=\"text-align:center;flex:1;min-width:140px;\">\ud83c\udf0d<br \/><strong>\u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae<\/strong><br \/>to most countries<\/div>\n<div style=\"text-align:center;flex:1;min-width:140px;\">\u2b50<br \/><strong>1,400+ customers<\/strong><br \/><a href=\"https:\/\/medsbase.com\/el\/reviews\/\">\u03b4\u03b9\u03b1\u03b2\u03ac\u03c3\u03c4\u03b5 \u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2<\/a><\/div>\n<\/div>\n<h2>\ud83d\udd12 Why order Itrotab from MedsBase<\/h2>\n<ul>\n<li><strong>\u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03b7 WHO-GMP \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae<\/strong> \u2014 sourced from a regulated facility, finished pack with batch number and expiry.<\/li>\n<li><strong>\u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1<\/strong> \u2014 plain envelope, no medication name on the outside.<\/li>\n<li><strong>\u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae<\/strong> to most countries with <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance<\/a>.<\/li>\n<li><strong>Loyalty points<\/strong> \u2014 1 point per $1 spent (excludes peptides\/shipping); 100 points = $5 off your next order.<\/li>\n<\/ul>\n<h2 id=\"uses\">Uses &#038; indications<\/h2>\n<p>Itrotab (itraconazole 100 mg \/ 200 mg, Pulse Pharmaceuticals) is a broad-spectrum triazole antifungal active against dermatophytes, yeasts (Candida), dimorphic fungi (Histoplasma, Blastomyces, Sporothrix, Paracoccidioides), and most Aspergillus species. The capsule is the standard oral formulation; a separate oral solution exists with different food-rules (taken on an empty stomach) and is the preferred form for oesophageal candidiasis.<\/p>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:0.95em;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">\u0395\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Typical regimen<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Onychomycosis (toenail)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Pulse: 200 mg twice daily \u00d7 1 week per month, repeat \u00d7 3 pulses (or continuous 200 mg\/day \u00d7 12 weeks)<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Onychomycosis (fingernail)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Pulse: 200 mg twice daily \u00d7 1 week per month \u00d7 2 pulses<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Tinea pedis \/ cruris \/ corporis<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">100 mg\/day \u00d7 15 days OR 200 mg\/day \u00d7 7 days<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Pityriasis versicolor<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">200 mg\/day \u00d7 7 days<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Oropharyngeal candidiasis<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">100\u2013200 mg\/day \u00d7 7\u201314 days<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Histoplasmosis \/ blastomycosis<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">200 mg twice daily \u00d7 6\u201312 months (induction with amphotericin B in severe disease)<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Aspergillosis (after voriconazole \/ amphotericin B)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">200 mg twice daily, duration depends on response<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"how-to-take\">How to take \u2014 the absorption rule matters<\/h2>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 20px;margin:20px 0;border-radius:6px;\"><strong>Capsule absorption is acid-dependent<\/strong><\/p>\n<div>Take itraconazole capsules with a full meal AND with an acidic drink (cola, orange juice). Acid is required to dissolve the capsule&#8217;s coating. PPIs (omeprazole, pantoprazole) and H2-blockers (famotidine, ranitidine) <strong>halve absorption<\/strong>. If you must continue acid-suppression therapy, take itraconazole with a cola; consider switching to the oral solution (taken on empty stomach) or to an alternative azole (fluconazole, voriconazole).<\/div>\n<\/div>\n<ul>\n<li>Swallow whole \u2014 do not crush or chew.<\/li>\n<li>Take at the same times each day to keep blood levels steady.<\/li>\n<li>Do not stop early \u2014 onychomycosis pulse therapy needs all 3 pulses even though nails take months to look normal.<\/li>\n<li>If you take an antacid, separate by at least 2 hours.<\/li>\n<\/ul>\n<h2 id=\"mechanism\">\u03a0\u03ce\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af<\/h2>\n<p>Itraconazole inhibits fungal CYP51 (14-\u03b1-demethylase), blocking conversion of lanosterol to ergosterol and weakening the fungal cell membrane. Compared to fluconazole, itraconazole is more lipophilic \u2014 it concentrates in skin, nails, and adipose tissue at concentrations 4\u201310\u00d7 plasma levels, and persists in the nail bed for weeks after dosing. This is why pulse-dosing works for onychomycosis: you only need 1 week of dosing per month because the drug stays in the nail.<\/p>\n<h2 id=\"side-effects\">Side effects &#038; monitoring<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:0.95em;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Typical effects<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Common (\u22651\/100)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Nausea, abdominal pain, diarrhoea, headache, transient LFT rise, rash, peripheral oedema<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">\u0391\u03c3\u03c5\u03bd\u03ae\u03b8\u03b9\u03c3\u03c4\u03b5\u03c2<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Hypokalaemia, dizziness, menstrual disorders, alopecia, paraesthesia<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">\u03a3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b1\u03bb\u03bb\u03ac \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Hepatotoxicity (FDA black-box: stop if jaundice, dark urine, persistent nausea), congestive heart failure (FDA black-box: avoid in symptomatic LV dysfunction), severe skin reactions (SJS\/TEN), peripheral neuropathy, hearing loss<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 20px;margin:20px 0;border-radius:6px;\"><strong>Heart-failure warning (FDA black-box)<\/strong><\/p>\n<div>Itraconazole has a dose-related negative inotropic effect. Do not use itraconazole in patients with current or past congestive heart failure or ventricular dysfunction unless the benefit clearly outweighs the risk and the patient is monitored for signs of CHF (dyspnoea, leg oedema, weight gain, fatigue). For onychomycosis specifically, itraconazole is contraindicated in patients with evidence of ventricular dysfunction.<\/div>\n<\/div>\n<h2 id=\"interactions\">Drug interactions \u2014 itraconazole is a strong CYP3A4 inhibitor<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:0.95em;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">\u03a6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">\u0391\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">\u0394\u03c1\u03ac\u03c3\u03b7<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">PPIs \/ H2-blockers \/ antacids<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Reduce capsule absorption<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Take with cola; or use oral solution; or hold acid-suppression<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Rifampicin \/ rifabutin \/ phenytoin \/ carbamazepine \/ phenobarbital<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">CYP3A4 induction \u2192 low itraconazole levels<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Avoid combination \u2014 switch antifungal class<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Simvastatin \/ atorvastatin \/ lovastatin<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Statin levels rise \u2192 rhabdomyolysis<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Stop statin during itraconazole; or switch to pravastatin \/ rosuvastatin<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Quinidine, dofetilide, pimozide, cisapride, terfenadine<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">QT prolongation \u2192 torsades<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">\u0391\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03b5\u03c4\u03b1\u03b9<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Midazolam (oral), triazolam, alprazolam<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Excessive sedation<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Avoid; use lorazepam (non-CYP)<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Tacrolimus \/ ciclosporin \/ sirolimus<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Levels rise \u2014 toxicity<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Reduce dose 50%; trough monitoring<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">\u0392\u03b1\u03c1\u03c6\u03b1\u03c1\u03af\u03bd\u03b7<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">INR rises<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Monitor INR; reduce warfarin<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Vinca alkaloids (vincristine, vinblastine)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Neurotoxicity, ileus<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">\u0391\u03c0\u03bf\u03c6\u03cd\u03b3\u03b5\u03c4\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Buprenorphine, fentanyl<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Increased opioid effect<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Reduce opioid dose; monitor sedation<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Apixaban, rivaroxaban, edoxaban<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">DOAC levels rise \u2014 bleeding<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Avoid combination; bridge with LMWH<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"contraindications\">Who should not take itraconazole<\/h2>\n<ul>\n<li>Symptomatic congestive heart failure or ventricular dysfunction (for onychomycosis indication especially).<\/li>\n<li>Pregnancy (animal teratogenicity, contraindicated except in serious systemic mycoses).<\/li>\n<li>Concurrent QT-prolonging drugs listed above.<\/li>\n<li>Concurrent simvastatin\/atorvastatin\/lovastatin at full dose.<\/li>\n<li>Severe hepatic impairment or active hepatitis.<\/li>\n<\/ul>\n<h2 id=\"pregnancy\">Pregnancy &#038; breastfeeding<\/h2>\n<p>Itraconazole is contraindicated in pregnancy for onychomycosis (a non-life-threatening indication). For systemic mycoses (histoplasmosis, blastomycosis, aspergillosis), benefits may outweigh risks \u2014 discuss with a specialist. Effective contraception is required during therapy and for 2 months after the last dose. Itraconazole is excreted in breast milk at low levels \u2014 short courses may be compatible; prolonged maintenance therapy is not recommended during breastfeeding.<\/p>\n<h2 id=\"faqs\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3>How long until my nail looks normal?<\/h3>\n<p>The drug clears the fungus in 12 weeks but the dead nail keeps growing out for months. Toenails take 9\u201312 months to look fully normal; fingernails 4\u20136 months. Photo at month 0, 3, 6, 12 to track progress objectively.<\/p>\n<h3>What is &#8216;pulse therapy&#8217; and why does it work?<\/h3>\n<p>Itraconazole concentrates in the nail at 4\u201310\u00d7 plasma levels and persists for weeks after dosing. Pulse therapy = 200 mg twice daily for 1 week, then 3 weeks off, repeat \u00d7 3. Cumulative cure rate for toenails ~70%, similar to continuous dosing but with less drug exposure and lower cost.<\/p>\n<h3>Why does my doctor want an ECG before I start?<\/h3>\n<p>Itraconazole has a negative inotropic effect and can prolong QT. Patients with risk factors (existing heart failure, age &gt; 70, previous cardiotoxic chemotherapy) should have a baseline ECG. Look for prolonged QTc &gt; 500 ms \u2014 itraconazole would be avoided.<\/p>\n<h3>Can I take itraconazole with my omeprazole?<\/h3>\n<p>Itraconazole capsule absorption is reduced by 40\u201360% on a PPI. Either: (a) hold the PPI during the 1-week pulse, (b) take itraconazole with a cola to provide acid, or (c) switch to itraconazole oral solution (different formulation, taken on empty stomach), or (d) use terbinafine instead (no acid requirement).<\/p>\n<h3>Itraconazole vs terbinafine for toenail fungus \u2014 which is better?<\/h3>\n<p>For dermatophyte onychomycosis (the common cause), terbinafine 250 mg daily \u00d7 12 weeks has a slightly higher cure rate (~76% vs ~63%) and fewer drug interactions. Itraconazole pulse is preferred when the cause is mixed (dermatophyte + non-dermatophyte mould or Candida) or when terbinafine is contraindicated.<\/p>\n<h3>Will my toenail fall off?<\/h3>\n<p>No \u2014 the dead, fungus-affected nail grows out from the cuticle. As new healthy nail grows in, the old discoloured portion is gradually clipped away over 9\u201312 months.<\/p>\n<h3>Can I drink alcohol while taking itraconazole?<\/h3>\n<p>Both itraconazole and alcohol stress the liver. Limit alcohol intake during therapy, especially during a 12-week continuous course. Avoid heavy drinking entirely. There is no acute disulfiram-like reaction.<\/p>\n<h3>What about pregnancy if I am of childbearing potential?<\/h3>\n<p>Itraconazole is teratogenic in animals. Use effective contraception during therapy and for 2 months after the last dose (the half-life from skin\/nail compartment is long). Onychomycosis is rarely treated during pregnancy \u2014 wait until after delivery and breastfeeding.<\/p>\n<h3>Why do I need LFTs before starting?<\/h3>\n<p>Itraconazole can cause hepatotoxicity including rare fatal cases. Baseline LFTs let you spot pre-existing abnormality. Repeat LFTs at 1 month if continuous; or at any sign of jaundice\/dark urine\/persistent nausea. Stop drug if AST\/ALT &gt; 3\u00d7 ULN.<\/p>\n<h3>What if I miss a dose during pulse therapy?<\/h3>\n<p>Take it as soon as you remember on the same day. If you miss a whole day, do not double up \u2014 the next day&#8217;s dose is sufficient. If you miss 2+ days during a 1-week pulse, complete the pulse and continue with the planned schedule.<\/p>\n<h2 id=\"storage\">\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7<\/h2>\n<p>Store capsules at 15\u201325 \u00b0C in the original blister, protected from light and moisture. Do not use after expiry. Keep out of reach of children.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Other Antifungal Medications you may be interested in<\/h2>\n<p>If Itrotab is unavailable, here are alternatives \u2014 same molecule from a different manufacturer, terbinafine for straightforward dermatophyte nail\/skin infections, or fluconazole for Candida.<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/zimig\/\"><strong>Zimig (terbinafine 250 mg)<\/strong><\/a> \u2014 First-line for dermatophyte onychomycosis; ~76% cure rate.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/sporanox-capsule\/\"><strong>Sporanox (itraconazole 100 mg)<\/strong><\/a> \u2014 Pulse therapy for non-dermatophyte mould or mixed Candida onychomycosis.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/grisovin-fp\/\"><strong>Grisovin FP (griseofulvin)<\/strong><\/a> \u2014 Tinea capitis caused by Microsporum (paediatric).<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/loceryl-nail-liq\/\"><strong>Loceryl (amorolfine 5%)<\/strong><\/a> \u2014 Topical lacquer for mild distal-edge nail fungus.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/zocon\/\"><strong>Zocon (fluconazole 150 mg)<\/strong><\/a> \u2014 Standard oral therapy for Candida (vaginal, oral, oesophageal thrush).<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 18px;margin:24px 0;font-size:0.95em;\"><strong>\u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03b5\u03c5\u03b8\u03c5\u03bd\u03ce\u03bd.<\/strong> This page is product information for adults ordering antifungal medicine for personal use. It is not a substitute for individual medical advice. Discuss the right antifungal, dose, and treatment duration with a qualified clinician \u2014 particularly if you have liver disease, are pregnant or breastfeeding, take warfarin, take a statin, take immunosuppressants, or have a fungal nail infection that may be a different diagnosis (psoriasis, lichen planus, trauma).<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u2705 Fungal infection treatment<br \/>\n\u2705 Oral antifungal medication<br \/>\n\u2705 Targets skin infections<br \/>\n\u2705 Effectively treats candidiasis<br \/>\n\u2705 Alleviates nail fungus<\/p>\n<p>Itrotab contains Itraconazole<\/p>","protected":false},"featured_media":57720,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3501,3141,3504,3342],"product_tag":[3627,4351],"class_list":{"0":"post-57719","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-fungal","7":"product_cat-category-overview","8":"product_cat-fungal-infection-treatment","9":"product_cat-general-health","10":"product_tag-itraconazole","11":"product_tag-itrotab","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/57719","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=57719"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/57720"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=57719"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=57719"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=57719"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=57719"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}