{"id":57801,"date":"2024-02-27T18:00:53","date_gmt":"2024-02-27T18:00:53","guid":{"rendered":"https:\/\/medsname.com\/ivimec\/"},"modified":"2026-05-07T07:15:50","modified_gmt":"2026-05-07T07:15:50","slug":"ivimec","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/ivimec\/","title":{"rendered":"Ivimec"},"content":{"rendered":"

<\/p>\n

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Quick Answer — What is Ivimec?<\/h3>\n
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Ivimec<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 ivermectin 6 mg \/ 12 mg dispersible tablet<\/strong> \u03b1\u03c0\u03cc Lupin<\/strong>. Ivermectin is the WHO-listed first-line agent for strongyloidiasis, scabies, head lice, and onchocerciasis (river blindness)<\/strong>. Standard adult dose is 200 µg\/kg as a single dose, repeated at day 7–14<\/strong> for scabies. Take on an empty stomach with water.<\/p>\n

The dispersible-tablet (DT) format is designed for paediatric and difficult-swallow use — place the tablet in 5–10 ml of water, allow to disperse, and drink immediately.<\/p>\n<\/div>\n<\/div>\n

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\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n

\u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n

What is Ivimec?<\/h2>\n

Ivimec<\/strong> is an oral ivermectin product manufactured by Lupin<\/strong>, available in 6 mg \/ 12 mg<\/strong> strengths. Ivermectin is one of the most important drugs in global health — the 2015 Nobel Prize in Physiology or Medicine recognised its discoverers (William Campbell & Satoshi Ōmura) for the contribution it made to controlling river blindness and lymphatic filariasis. Today ivermectin is on the WHO Model List of Essential Medicines and remains first-line for several human parasitic and ectoparasitic diseases.<\/p>\n

Mechanism — how ivermectin kills parasites<\/h2>\n

Ivermectin binds with high affinity to glutamate-gated chloride channels<\/strong> in invertebrate nerve and muscle cells. This opens the channel, hyperpolarises the cell, and paralyses the parasite. Mammalian cells lack glutamate-gated chloride channels (mammalian GABA channels are the closest relative, but ivermectin does not cross an intact blood-brain barrier in normal doses), which is why ivermectin has a wide safety margin in humans.<\/p>\n

Ivermectin is highly lipophilic, peaks in plasma at 4–5 hours, and has an elimination half-life of 16–28 hours. Most of the drug is excreted in faeces.<\/p>\n

Ivimec indications<\/h2>\n\n\n\n\n\n\n\n\n\n\n
\u0395\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/th>\n\u0394\u03cc\u03c3\u03b7<\/th>\n\u03a3\u03b7\u03bc\u03b5\u03b9\u03ce\u03c3\u03b5\u03b9\u03c2<\/th>\n<\/tr>\n<\/thead>\n
Strongyloidiasis<\/td>\n200 µg\/kg single dose<\/td>\nRepeat at 14 days in immunocompromised; pre-emptive screening before steroids<\/td>\n<\/tr>\n
Scabies<\/td>\n200 µg\/kg, repeat at day 7–14<\/td>\nTreat all household contacts simultaneously; topical permethrin alternative<\/td>\n<\/tr>\n
Head lice<\/td>\n200 µg\/kg, repeat at day 7<\/td>\nUseful when topical pediculicides have failed<\/td>\n<\/tr>\n
Onchocerciasis<\/td>\n150 µg\/kg single dose, every 6–12 months<\/td>\nWHO mass-drug-administration regimen<\/td>\n<\/tr>\n
Lymphatic filariasis<\/td>\n200 µg\/kg with albendazole 400 mg<\/td>\nAnnual MDA combination therapy<\/td>\n<\/tr>\n
Cutaneous larva migrans<\/td>\n200 µg\/kg single dose<\/td>\nOften a one-shot cure<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Ivimec dosage — weight-based<\/h2>\n

Ivermectin is dosed at 200 µg per kg of body weight<\/strong> for most indications (150 µg\/kg for onchocerciasis). Convert as follows:<\/p>\n\n\n\n\n\n\n\n\n\n\n
Body weight<\/th>\nApprox. dose<\/th>\nTablet equivalent<\/th>\n<\/tr>\n<\/thead>\n
15–25 kg<\/td>\n3 mg<\/td>\n1 × 3 mg<\/td>\n<\/tr>\n
26–44 kg<\/td>\n6 mg<\/td>\n1 × 6 mg or 2 × 3 mg<\/td>\n<\/tr>\n
45–64 kg<\/td>\n9 mg<\/td>\n1 × 6 mg + 1 × 3 mg<\/td>\n<\/tr>\n
65–84 kg<\/td>\n12 mg<\/td>\n1 × 12 mg<\/td>\n<\/tr>\n
85–104 kg<\/td>\n15 mg<\/td>\n1 × 12 mg + 1 × 3 mg<\/td>\n<\/tr>\n
105–120 kg<\/td>\n18 mg<\/td>\n2 × 6 mg + 2 × 3 mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Take on an empty stomach<\/strong> with a full glass of water (food increases bioavailability roughly 2.5×, which can change the safety margin in patients with high microfilarial load).<\/p>\n

Loa loa pre-screening (Sub-Saharan Africa).<\/strong> In patients from West\/Central Africa with potential Loa loa<\/em> co-infection, ivermectin can precipitate severe encephalopathy if microfilarial load is high. Pre-treatment Nopch test or microfilarial count is mandatory in endemic regions. Outside Africa this is not a concern.<\/div>\n

\u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/h2>\n

Ivermectin is generally very well tolerated. The most common side effects are Mazzotti reaction<\/strong> (fever, pruritus, lymphadenopathy, joint pain — caused by dying microfilariae, not the drug itself) in patients with onchocerciasis or lymphatic filariasis. Other reactions:<\/p>\n