{"id":58071,"date":"2024-02-27T18:16:05","date_gmt":"2024-02-27T18:16:05","guid":{"rendered":"https:\/\/medsname.com\/lox-10-spray\/"},"modified":"2026-05-25T06:58:23","modified_gmt":"2026-05-25T06:58:23","slug":"lox-10-spray","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/lox-10-spray\/","title":{"rendered":"Lox 10% Spray"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff9e6;border-left:4px solid #f5a623;padding:16px 20px;margin:16px 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;\">&#9889; Quick Answer &mdash; What is Lox 10% Spray?<\/h3>\n<p style=\"margin:0;\"><strong>Lox 10% Spray<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 <strong>lidocaine 10% topical spray<\/strong> (50 ml metered-dose pump bottle) used for <strong>surface anaesthesia<\/strong> of skin and mucous membranes before minor procedures &mdash; dental work, IV cannulation, intubation, endoscopy, ENT procedures, cervical instrumentation and skin biopsies. Each actuation delivers approximately <strong>10 mg of lidocaine<\/strong>. Onset is <strong>1&ndash;3 minutes<\/strong>; duration <strong>30\u201360 \u03bb\u03b5\u03c0\u03c4\u03ac<\/strong>. <strong>Do not exceed 20 sprays (200 mg) in a single session<\/strong> for an adult, and keep total doses well below the 3 mg\/kg lidocaine limit. Not for use on broken skin, inflamed mucosa or infants under 2 &mdash; systemic absorption rises sharply. Off-label: some patients apply a measured dose to the glans penis to delay ejaculation; this carries partner-numbing and absorption risks and should be discussed with a clinician.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong> \u03a0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2 WHO-GMP \u00b7 \u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u00b7 \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u00b7 1,400+ \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 <a href=\"https:\/\/medsbase.com\/el\/reviews\/\">\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\"><strong>\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n<h3>\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n<p>\u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n<div style=\"background:#f4f8fb;border:1px solid #e0e0e0;padding:12px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;text-align:center;\">\n<strong>\ud83d\udd12 \u039a\u03c1\u03c5\u03c0\u03c4\u03bf\u03b3\u03c1\u03b1\u03c6\u03b7\u03bc\u03ad\u03bd\u03b7 \u039f\u03bb\u03bf\u03ba\u03bb\u03ae\u03c1\u03c9\u03c3\u03b7 \u0391\u03b3\u03bf\u03c1\u03ac\u03c2<\/strong> \u00b7 <strong>\ud83d\udcb3 \u0395\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf\u03c2 \u0395\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c2<\/strong> \u00b7 <strong>\ud83d\ude9a \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u0391\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae<\/strong> \u00b7 <strong>\u2b50 4.9\/5 \u03b1\u03c0\u03cc 1,400+ \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2<\/strong>\n<\/div>\n<h2 class=\"wp-block-heading\">What Is Lox 10% Spray?<\/h2>\n<p>Lox 10% Spray is a <strong>10% lidocaine topical spray<\/strong> supplied as a 50 ml metered pump bottle by Neon Laboratories. Each <strong>metered actuation delivers approximately 10 mg of lidocaine<\/strong> as an aqueous\/ethanolic spray that rapidly coats skin or accessible mucosal surfaces. The same lidocaine 10% topical spray is sold as <strong>Xylocaine 10% Spray<\/strong> (AstraZeneca) in many countries and as generic alternatives globally.<\/p>\n<p>Lidocaine is the world&#39;s most widely used amide-type <strong>local anaesthetic<\/strong>. It is on the WHO List of Essential Medicines. At 10% concentration in a spray, its dominant clinical use is <strong>surface numbing of mucosal tissues and skin<\/strong> immediately before a brief, painful procedure. The spray format is preferred over a 2% gel when rapid coverage of a large area is needed (e.g. oropharynx before intubation) or where a fine liquid mist reaches angles that a gel cannot.<\/p>\n<p>Lox 10% Spray is <strong>\u03b4\u03b5\u03bd<\/strong> the same as injectable lidocaine used for infiltration anaesthesia (dentist&#39;s syringe), nor the same as the cream forms (EMLA, ELA-Max) used for intact skin analgesia &mdash; those creams contain 2.5% lidocaine and need 30&ndash;60 minutes under occlusion to work. Surface spray takes only minutes but does not penetrate intact thick skin deeply enough for a full skin biopsy; it numbs the surface mucosa only.<\/p>\n<h2 class=\"wp-block-heading\">How Does Lox 10% Spray Work?<\/h2>\n<p>Lidocaine reversibly <strong>blocks voltage-gated sodium channels<\/strong> in nerve membranes. Without the sodium flux that triggers action potentials, pain signals cannot travel along the nerve &mdash; the area becomes numb until the drug diffuses away and is metabolised. Lidocaine preferentially blocks small, fast-firing pain fibres (A-delta and C) before larger motor fibres, which is why patients keep motor function in the treated area while losing sharp pain sensation.<\/p>\n<p>After topical application to mucosa, onset of numbing is <strong>1&ndash;3 minutes<\/strong>; peak effect at 5&ndash;10 minutes; duration <strong>30\u201360 \u03bb\u03b5\u03c0\u03c4\u03ac<\/strong>. Lidocaine is metabolised in the liver by CYP1A2 and CYP3A4 to MEGX and GX metabolites and excreted renally &mdash; plasma half-life is around 1.5&ndash;2 hours.<\/p>\n<h2 class=\"wp-block-heading\">\u03a7\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li><strong>Dentistry<\/strong> &mdash; surface numbing of gingiva before needle insertion for infiltration anaesthesia; minor periodontal instrumentation; scaling<\/li>\n<li><strong>Intubation and airway instrumentation<\/strong> &mdash; numbing of the oropharynx, tongue base and vocal cords before laryngoscopy, bronchoscopy, tracheal intubation or transoesophageal echo<\/li>\n<li><strong>Upper GI endoscopy<\/strong> &mdash; spray to oropharynx before scope passage<\/li>\n<li><strong>ENT procedures<\/strong> &mdash; anterior and posterior rhinoscopy, middle-ear examination, direct laryngoscopy, indirect laryngoscopy, removal of foreign bodies from ear\/nose<\/li>\n<li><strong>Gynaecology and urology<\/strong> &mdash; cervical instrumentation (IUD insertion, biopsy), urethral meatus spray before catheterisation or cystoscopy<\/li>\n<li><strong>Rectal procedures<\/strong> &mdash; proctoscopy, anoscopy (spray to anal verge only; not for deep rectal use)<\/li>\n<li><strong>IV cannulation<\/strong> &mdash; surface spray 1&ndash;2 minutes before needle in needle-phobic or paediatric patients (adjunctive to EMLA\/creams)<\/li>\n<li><strong>Dermatology<\/strong> &mdash; surface numbing before curettage of small lesions, electrocautery of skin tags, minor biopsies (thin lesions only)<\/li>\n<li><strong>Off-label for premature ejaculation<\/strong> &mdash; a measured dose applied to the glans penis 10&ndash;15 minutes before intercourse can delay ejaculation. Wipe residue before penetration to avoid partner numbing; use a condom. Discuss with a clinician; for persistent PE, dapoxetine is the licensed oral option.<\/li>\n<\/ul>\n<p>Lox 10% Spray is <strong>not appropriate<\/strong> for: infiltration anaesthesia (use injectable lidocaine), deep skin biopsies (surface spray does not penetrate thick skin), eye\/conjunctival use (specific ophthalmic products are needed), or wound irrigation (use injectable lidocaine or sterile saline).<\/p>\n<h2 class=\"wp-block-heading\">Lox 10% Spray Dosage<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Procedure \/ site<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Typical sprays<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Max single session (adult)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Dental &mdash; single gingival site<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>1&ndash;2 sprays<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">20 sprays (200 mg)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Oropharynx before intubation<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>3&ndash;5 sprays<\/strong> each on tonsillar pillars, posterior pharynx, tongue base<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">20 sprays<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Nasal procedure (per nostril)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>2&ndash;3 sprays<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">10 per nostril<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Urethral meatus before catheter<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>1&ndash;2 sprays<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">4 total<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Cervix (IUD, biopsy)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>2&ndash;4 sprays<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">6<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Children 2&ndash;12 years<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Weight-based &mdash; max 3 mg\/kg total<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Calculate &mdash; e.g. 20 kg child = 60 mg max = 6 sprays<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Adult maximum single session: 20 sprays (200 mg lidocaine).<\/strong> Do not exceed 3 mg\/kg of lidocaine total for any patient in any single session. In debilitated, elderly or hepatic-impaired patients, reduce to 50% of the usual dose.<\/p>\n<h3 class=\"wp-block-heading\">How to Use Lox 10% Spray Properly<\/h3>\n<ol>\n<li><strong>Shake the bottle gently<\/strong> and prime by holding it vertical and pressing the pump 1&ndash;2 times into a tissue or the air, away from the patient&#39;s face.<\/li>\n<li><strong>Hold the nozzle 5&ndash;10 cm from the target<\/strong>. Aim away from the patient&#39;s eyes &mdash; lidocaine on the cornea causes immediate severe stinging but is not dangerous.<\/li>\n<li><strong>Press the pump once per metered dose<\/strong>. Each actuation delivers ~10 mg. Count doses aloud or note them on paper to track total.<\/li>\n<li><strong>Wait 1&ndash;3 minutes<\/strong> for onset before beginning the procedure. Mucosa will look slightly blanched; patient should report loss of sharp-touch sensation.<\/li>\n<li><strong>Do not exceed the per-session maximum<\/strong> &mdash; track spray count, especially in long procedures.<\/li>\n<li><strong>Wipe the external nozzle<\/strong> after each use to avoid cross-contamination; ideally use a new dose each patient, or single-patient bottles in clinical settings.<\/li>\n<li>After the procedure, <strong>advise the patient not to eat or drink for 1 hour<\/strong> after oropharyngeal spray &mdash; the gag reflex is impaired and aspiration risk is real.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Side Effects of Lox 10% Spray<\/h2>\n<p><strong>Common (usually transient):<\/strong><\/p>\n<ul>\n<li>Brief stinging or burning on application<\/li>\n<li>Bitter taste after oropharyngeal use<\/li>\n<li>Mild erythema at the application site<\/li>\n<li>Numbness persisting 30&ndash;60 minutes after the procedure<\/li>\n<li>Reduced gag reflex after oropharyngeal spray (1 hour NPO needed)<\/li>\n<\/ul>\n<p><strong>\u039b\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03c5\u03c7\u03bd\u03ad\u03c2:<\/strong><\/p>\n<ul>\n<li>Contact dermatitis (amide hypersensitivity is rare; ester anaesthetic hypersensitivity is more common)<\/li>\n<li>Methaemoglobinaemia &mdash; particularly with high total dose, in infants, or with benzocaine co-application<\/li>\n<li>Dizziness, lightheadedness (early systemic toxicity sign)<\/li>\n<\/ul>\n<p><strong>Serious &mdash; Local Anaesthetic Systemic Toxicity (LAST), stop and treat:<\/strong><\/p>\n<ul>\n<li>Perioral numbness, metallic taste, tinnitus &mdash; earliest CNS signs<\/li>\n<li>Slurred speech, tremor, dysarthria &mdash; progression<\/li>\n<li>Seizures &mdash; mid-severity CNS toxicity<\/li>\n<li>Hypotension, bradycardia, arrhythmia &mdash; cardiovascular toxicity (very high doses)<\/li>\n<li>Cardiac arrest &mdash; if any of these develop, stop, support airway\/breathing\/circulation, and consider <strong>intralipid 20% IV<\/strong> (1.5 ml\/kg bolus then 0.25 ml\/kg\/min infusion)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u03a0\u03c1\u03bf\u03b5\u03b9\u03b4\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03ac\u03be\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li><strong>Track total dose.<\/strong> Absolute maximum is 3 mg\/kg or 200 mg in an adult &mdash; whichever is lower. Count sprays.<\/li>\n<li><strong>Avoid broken skin, inflamed mucosa or traumatised tissue<\/strong> &mdash; absorption rises sharply and LAST becomes more likely.<\/li>\n<li><strong>\u0397\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1<\/strong> reduces lidocaine clearance &mdash; use half the usual dose.<\/li>\n<li><strong>Cardiac conduction disease<\/strong> (high-grade AV block, pacemaker dependency): use cautiously; lidocaine prolongs AV conduction.<\/li>\n<li><strong>\u039a\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1<\/strong> reduces hepatic blood flow and clearance &mdash; halve the dose.<\/li>\n<li><strong>Elderly \/ debilitated:<\/strong> reduce to 50% dose; lidocaine plasma half-life is longer.<\/li>\n<li><strong>Infants and small children:<\/strong> calculate 3 mg\/kg max carefully. Avoid in infants under 2 except under anaesthetic supervision.<\/li>\n<li><strong>Post-oropharyngeal spray:<\/strong> 1 hour NPO (nothing by mouth) &mdash; aspiration risk.<\/li>\n<li><strong>Do not spray into the eye<\/strong> &mdash; severe irritation. Use ophthalmic lidocaine (0.5%) if eye anaesthesia needed.<\/li>\n<li><strong>\u0395\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7:<\/strong> FDA Category B &mdash; small topical doses are considered safe; discuss with obstetrician.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u0391\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li>Known hypersensitivity to lidocaine, other amide-type local anaesthetics, or any formulation excipient<\/li>\n<li>Second- or third-degree AV block (without pacemaker)<\/li>\n<li>Wolff-Parkinson-White syndrome (relative)<\/li>\n<li>Severe sinoatrial or intraventricular conduction disease<\/li>\n<li>Porphyria &mdash; lidocaine can precipitate an acute attack<\/li>\n<li>Infants under 2 years (relative; specialist-only decision)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03a6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Interacting drug<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u0391\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u03a4\u03b9 \u03bd\u03b1 \u03ba\u03ac\u03bd\u03b5\u03c4\u03b5<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Class I and III antiarrhythmics (mexiletine, amiodarone, quinidine)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Additive cardiac conduction slowing<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reduce dose; ECG monitoring in cardiac patients<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Cimetidine, ranitidine<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reduce hepatic clearance of lidocaine &mdash; higher plasma levels<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Halve dose; use alternate H2 blocker or PPI<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Beta-blockers (propranolol)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reduced hepatic blood flow &mdash; slower lidocaine clearance<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor for early LAST signs<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">CYP3A4 inhibitors (ketoconazole, ritonavir, erythromycin)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Slowed lidocaine metabolism<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reduce dose; monitor<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Other local anaesthetics (benzocaine, prilocaine)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Additive systemic toxicity; benzocaine adds methaemoglobinaemia risk<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Do not combine at maximal doses<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Dapsone, nitric-oxide donors, metoclopramide (high-dose)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Increase methaemoglobinaemia risk with lidocaine<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Caution; avoid stacking<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7<\/h2>\n<ul>\n<li>\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7 \u03ba\u03ac\u03c4\u03c9 \u03b1\u03c0\u03cc <strong>25&deg;C<\/strong> in a dry place.<\/li>\n<li>Keep the bottle upright to ensure the pump primes correctly.<\/li>\n<li>Do not expose to direct sunlight, flame or sparks &mdash; the propellant vehicle contains ethanol and is flammable.<\/li>\n<li>Discard 12 months after first opening.<\/li>\n<li>\u039c\u03b7\u03bd \u03b1\u03c6\u03ae\u03bd\u03b5\u03c4\u03b5 \u03c3\u03b5 \u03bc\u03ad\u03c1\u03b7 \u03c0\u03c1\u03bf\u03c3\u03b2\u03ac\u03c3\u03b9\u03bc\u03b1 \u03b1\u03c0\u03cc \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u039b\u03cd\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/crocin-advance\/\"><strong>Crocin Advance (paracetamol 500 mg, fast-dispersing) &mdash; rapid-onset analgesic<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/meftal\/\"><strong>Meftal (mefenamic acid 250 \/ 500 mg) &mdash; NSAID for period pain and inflammation<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/hyloric\/\"><strong>Hyloric (allopurinol 100 \/ 300 mg) &mdash; gout prophylaxis<\/strong><\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3 class=\"wp-block-heading\">Is Lox 10% Spray the same as Xylocaine 10% Spray?<\/h3>\n<p>Yes &mdash; the formulation (lidocaine 10% topical spray, ~10 mg per actuation, 50 ml bottle) is clinically interchangeable with <strong>Xylocaine 10% Spray<\/strong> (AstraZeneca) and other generic 10% lidocaine sprays worldwide. The drug, concentration and delivery method are identical.<\/p>\n<h3 class=\"wp-block-heading\">How long does Lox 10% Spray last?<\/h3>\n<p>Onset is <strong>1&ndash;3 minutes<\/strong>; full anaesthetic depth at 5&ndash;10 minutes; surface numbness persists <strong>30\u201360 \u03bb\u03b5\u03c0\u03c4\u03ac<\/strong>. For oropharyngeal use, the gag reflex remains impaired for around <strong>1 \u03ce\u03c1\u03b1<\/strong> &mdash; do not eat or drink during that window to avoid aspiration.<\/p>\n<h3 class=\"wp-block-heading\">What is the maximum safe dose?<\/h3>\n<p><strong>3 mg\/kg of lidocaine, or 200 mg total, whichever is lower.<\/strong> For an adult that is <strong>20 sprays<\/strong> in a single session. For a 30 kg child, it is 90 mg \/ 9 sprays. Halve the dose in elderly, hepatic-impaired and cardiac-failure patients.<\/p>\n<h3 class=\"wp-block-heading\">Can I use Lox 10% Spray for premature ejaculation?<\/h3>\n<p>Some men apply a measured dose (1&ndash;2 sprays) to the glans penis 10&ndash;15 minutes before intercourse to delay ejaculation. This is off-label &mdash; efficacy is real but three practical issues matter: (1) residual lidocaine numbs the partner, so wipe thoroughly and use a condom; (2) do not exceed 2 sprays per use &mdash; more does not improve the effect but does increase LAST risk; (3) for persistent PE, <strong>\u03b4\u03b1\u03c0\u03bf\u03be\u03b5\u03c4\u03af\u03bd\u03b7<\/strong> (sold as Poxet, Priligy and Super Vilitra\/Super P-Force in combination with PDE5 inhibitors) is the licensed oral option with better sustained efficacy. Discuss with a clinician.<\/p>\n<h3 class=\"wp-block-heading\">Can Lox 10% Spray be used on children?<\/h3>\n<p>Yes, with care. Calculate maximum total dose as <strong>3 mg\/kg<\/strong> (one spray = 10 mg). For a 20 kg child the ceiling is 60 mg = 6 sprays in a single session. Avoid in infants under 2 except under anaesthetic supervision &mdash; the skin\/mucosa absorption in infants is higher and methaemoglobinaemia risk is greater.<\/p>\n<h3 class=\"wp-block-heading\">What are the first signs of lidocaine toxicity (LAST)?<\/h3>\n<p>The earliest CNS signs are <strong>perioral numbness, metallic taste, tinnitus, and lightheadedness<\/strong> &mdash; these develop within minutes of a high dose. If any appear, stop applying, call for help and place the patient in a safe position. Progression is to slurred speech, tremor, seizures, then cardiovascular collapse. Treatment is airway\/breathing\/circulation support and <strong>intralipid 20% IV<\/strong> in severe cases.<\/p>\n<h3 class=\"wp-block-heading\">Can Lox 10% Spray be used on open wounds?<\/h3>\n<p><strong>\u038c\u03c7\u03b9.<\/strong> Absorption from broken skin or inflamed mucosa is far higher than from intact surfaces &mdash; systemic toxicity risk rises. For wound cleaning or small open lacerations, use injectable lidocaine for infiltration anaesthesia (different product).<\/p>\n<h3 class=\"wp-block-heading\">Is Lox 10% Spray safe during pregnancy?<\/h3>\n<p>Lidocaine is FDA Pregnancy Category B &mdash; small topical doses are widely considered safe during pregnancy (e.g. dental and obstetric use). Avoid high total doses and discuss with your obstetrician if used for any non-urgent procedure.<\/p>\n<h3 class=\"wp-block-heading\">Why does my spray sting when I first apply it?<\/h3>\n<p>Brief stinging is the expected <strong>initial irritation<\/strong> of the ethanolic vehicle before numbness sets in &mdash; it resolves within 1&ndash;2 minutes as the anaesthetic takes effect. Severe persistent pain, rash, swelling, or difficulty breathing after application is <strong>\u03b4\u03b5\u03bd<\/strong> normal and may indicate an allergic reaction &mdash; stop use and seek medical review.<\/p>\n<p class=\"medsbase-link-boost-2026-05-04\" data-marker=\"mb-link-boost-lox-2-jelly\"><a href=\"https:\/\/medsbase.com\/el\/lox-10-spray\/\">Lox 10% Spray<\/a> delivers fast surface numbing at high concentration, but for catheterisation, cystoscopy, or sustained PE-delay use that benefits from a sterile lubricating gel format, switch to <a href=\"https:\/\/medsbase.com\/el\/lox-2-jelly\/\">Lox 2% Jelly (lidocaine 2% topical\/urethral)<\/a> \u2014 same lidocaine molecule, lower concentration, longer contact dwell.<\/p>\n<p class=\"medsbase-link-boost-2026-05-25\" data-marker=\"mb-link-boost-hynidase-injection\"><a href=\"https:\/\/medsbase.com\/el\/lox-10-spray\/\">Lox 10% Spray<\/a> gives rapid mucosal lignocaine anaesthesia, and for deeper infiltration the same active is often paired with <a href=\"https:\/\/medsbase.com\/el\/hynidase-injection\/\">Hynidase Injection (hyaluronidase 1500 IU)<\/a>, a spreading enzyme that helps the anaesthetic diffuse evenly across a wider tissue field.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2<\/h3>\n<p>\u0386\u03bb\u03bb\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 \u03c3\u03b5 <strong>\u03a7\u03c1\u03cc\u03bd\u03b9\u03b5\u03c2 \u03a0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2<\/strong> \u03c0\u03bf\u03c5 \u03bf\u03b9 \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/conimune-me\/\">Conimune ME<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/simvotin\/\">Simvotin<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/trinicalm-plus\/\">Trinicalm Plus<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/flexabenz-er\/\">Flexabenz ER<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/robinax\/\">Robinax<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Fast-acting pain relief<br \/>\n\u2705 Lidocaine spray<br \/>\n\u2705 Topical application<br \/>\n\u2705 Local anesthesia<br \/>\n\u2705 Convenient to use<\/p>\n<p>Lox 10% Spray contains Lidocaine.<\/p>","protected":false},"featured_media":58072,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3555],"product_tag":[4412,4415],"class_list":{"0":"post-58071","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-pain-relief-medication","9":"product_tag-lidocaine","10":"product_tag-lox-10-spray","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/58071","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=58071"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/58072"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=58071"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=58071"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=58071"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=58071"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}