<\/p>\n
Cosart H<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 50\/12.5 mg fixed-dose tablet<\/strong> of losartan 50 mg and hydrochlorothiazide<\/strong> from Abbott Healthcare — a \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03ae\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03b2\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 2<\/strong> \u03b3\u03b9\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c4\u03c9\u03bd \u03bf\u03c0\u03bf\u03af\u03c9\u03bd \u03b7 \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03af\u03b5\u03c3\u03b7 \u03b4\u03b5\u03bd \u03b5\u03bb\u03ad\u03b3\u03c7\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 Losar<\/a> (losartan monotherapy) alone. Adding a thiazide diuretic typically yields an additional \u03c0\u03c4\u03ce\u03c3\u03b7 \u03c3\u03c5\u03c3\u03c4\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2 5-10 mmHg<\/strong> \u03c0\u03ad\u03c1\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 ARB. \u039f\u03b9 \u03b4\u03cd\u03bf \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ce\u03c3\u03b5\u03c2 \u03b4\u03c1\u03bf\u03c5\u03bd \u03bc\u03ad\u03c3\u03c9 \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03ce\u03bd<\/strong> (\u03c4\u03bf ARB \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03b9 \u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03b1\u03b3\u03b3\u03b5\u03b9\u03bf\u03c4\u03b5\u03bd\u03c3\u03af\u03bd\u03b7\u03c2-II\u00b7 \u03c4\u03bf HCTZ \u03b5\u03be\u03b1\u03bd\u03c4\u03bb\u03b5\u03af \u03c4\u03bf \u03bd\u03ac\u03c4\u03c1\u03b9\u03bf \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03ae\u03c0\u03b9\u03b1 \u03cc\u03b3\u03ba\u03bf \u03c3\u03c5\u03c3\u03c4\u03bf\u03bb\u03ae) \u03ba\u03b1\u03b9 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03bc\u03bf\u03b9\u03b2\u03b1\u03af\u03b1 \u03b5\u03be\u03b9\u03c3\u03bf\u03c1\u03c1\u03bf\u03c0\u03b7\u03bc\u03ad\u03bd\u03b1 \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03c0\u03b1\u03c1\u03b5\u03bd\u03b5\u03c1\u03b3\u03b5\u03b9\u03ce\u03bd<\/strong> \u2014 \u03c4\u03bf HCTZ \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03bf \u03ba\u03ac\u03bb\u03b9\u03bf \u03b5\u03bd\u03ce \u03c4\u03bf ARB \u03c4\u03b5\u03af\u03bd\u03b5\u03b9 \u03bd\u03b1 \u03c4\u03bf \u03b1\u03c5\u03be\u03ae\u03c3\u03b5\u03b9, \u03bf\u03c0\u03cc\u03c4\u03b5 \u03bf \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03b5\u03b9 \u03b5\u03af\u03c4\u03b5 \u03c5\u03c0\u03bf\u03ba\u03b1\u03bb\u03b9\u03b1\u03b9\u03bc\u03af\u03b1 \u03b5\u03af\u03c4\u03b5 \u03c5\u03c0\u03b5\u03c1\u03ba\u03b1\u03bb\u03b9\u03b1\u03b9\u03bc\u03af\u03b1 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03ba\u03ac\u03b8\u03b5 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03be\u03b5\u03c7\u03c9\u03c1\u03b9\u03c3\u03c4\u03ac \u03c3\u03b5 \u03b9\u03c3\u03bf\u03b4\u03cd\u03bd\u03b1\u03bc\u03b5\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2. \u03a4\u03c5\u03c0\u03b9\u03ba\u03ae \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1: \u03ad\u03bd\u03b1 \u03b4\u03b9\u03c3\u03ba\u03af\u03bf \u03b7\u03bc\u03b5\u03c1\u03b7\u03c3\u03af\u03c9\u03c2. \u0391\u03c0\u03bf\u03bb\u03cd\u03c4\u03c9\u03c2 \u03b1\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03af\u03ba\u03bd\u03c5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7<\/strong> (\u03ba\u03b1\u03b9 \u03bf\u03b9 \u03b4\u03cd\u03bf \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ce\u03c3\u03b5\u03c2), \u03b1\u03bd\u03bf\u03c5\u03c1\u03af\u03b1 \u03ae \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 (eGFR <30)<\/strong>, \u03c5\u03c0\u03b5\u03c1\u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03b5 \u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b9\u03b1 (\u03c3\u03bf\u03c5\u03bb\u03c6\u03bf\u03bd\u03b1\u03bc\u03af\u03b4\u03b5\u03c2)<\/strong>, \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03bd\u03b1\u03c4\u03c1\u03b9\u03b1\u03b9\u03bc\u03af\u03b1<\/strong>. \u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ba\u03b1\u03bb\u03af\u03bf\u03c5, \u03bd\u03b1\u03c4\u03c1\u03af\u03bf\u03c5, \u03bf\u03c5\u03c1\u03b9\u03ba\u03bf\u03cd \u03ba\u03b1\u03b9 \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2.<\/p>\n<\/div>\n \ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n \u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n Cosart H is an oral fixed-dose combination tablet supplying losartan 50 mg<\/strong> \u03ba\u03b1\u03b9 \u03c5\u03b4\u03c1\u03bf\u03c7\u03bb\u03c9\u03c1\u03bf\u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b7 (HCTZ)<\/strong> in a single pill, made by Abbott Healthcare and supplied in 30-180 tablets. It combines two first-line antihypertensive drug classes in a ratio chosen for most patients who have progressed beyond ARB monotherapy. Losartan is the first ARB approved for clinical use<\/strong> (DuPont Merck 1995; originator brand Cozaar). Half-life ~2 hours for the parent drug and 6-9 hours for the active metabolite E-3174 (generated by CYP2C9 and CYP3A4).<\/p>\n \u0397 \u03c5\u03b4\u03c1\u03bf\u03c7\u03bb\u03c9\u03c1\u03bf\u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b7 (HCTZ) \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b8\u03b5\u03b9\u03b1\u03b6\u03b9\u03b4\u03b9\u03ba\u03cc \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03cc \u03c0\u03bf\u03c5 \u03b5\u03b9\u03c3\u03ae\u03c7\u03b8\u03b7 \u03c4\u03bf 1959 (MSD \u03c9\u03c2 HydroDiuril). \u03a0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03b9\u03bf \u03c3\u03c5\u03bd\u03c4\u03b1\u03b3\u03bf\u03b3\u03c1\u03b1\u03c6\u03bf\u03cd\u03bc\u03b5\u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03ac \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c4\u03ad\u03c4\u03b1\u03c1\u03c4\u03b7 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u03c0\u03c1\u03ce\u03c4\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2<\/strong> \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7, \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 \u03c4\u03b1 ARB, \u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 ACE \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03ba\u03b1\u03bd\u03b1\u03bb\u03b9\u03bf\u03cd \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5.<\/p>\n \u0397 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b5\u03bb\u03ad\u03b3\u03c7\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03ad\u03bd\u03b1 \u03bc\u03cc\u03bd\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03c3\u03b5 \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b4\u03cc\u03c3\u03b7. \u039c\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03bf\u03b9 ALLHAT, ACCOMPLISH \u03ba\u03b1\u03b9 ASCOT \u03ba\u03b1\u03c4\u03ad\u03c3\u03c4\u03b7\u03c3\u03b1\u03bd \u03cc\u03c4\u03b9 \u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03cd\u03bf \u03ae \u03c4\u03c1\u03af\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b1\u03c0\u03cc \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2<\/strong> \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03c0\u03b9\u03c4\u03b5\u03c5\u03c7\u03b8\u03bf\u03cd\u03bd \u03bf\u03b9 \u03c3\u03c4\u03cc\u03c7\u03bf\u03b9 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 (<140\/90 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5\u03c2 \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2, <130\/80 \u03b3\u03b9\u03b1 \u03b4\u03b9\u03b1\u03b2\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf). \u039f \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 ARB + \u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03c4\u03c1\u03b5\u03b9\u03c2 \u03b2\u03b1\u03c3\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03c3\u03b5 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b4\u03b5\u03b9\u03b3\u03bc\u03ad\u03bd\u03b1 \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03cd\u03c2 \u03b4\u03cd\u03bf \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd (\u03bf\u03b9 \u03ac\u03bb\u03bb\u03bf\u03b9 \u03b4\u03cd\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 ARB + CCB \u03ba\u03b1\u03b9 CCB + \u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b7\u03c2).<\/p>\n The two components of Cosart H complement each other on \u03c4\u03ad\u03c3\u03c3\u03b5\u03c1\u03b9\u03c2 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03ac\u03be\u03bf\u03bd\u03b5\u03c2<\/strong>:<\/p>\n Losartan is uniquely uricosuric among ARBs<\/strong> — it lowers serum uric acid by inhibiting the URAT1 transporter in the proximal tubule. This is clinically important in this combination, because HCTZ raises serum uric acid<\/strong> by competing for the same excretory pathway. The losartan-HCTZ combination is therefore the preferred ARB+thiazide pairing for patients with gout, hyperuricaemia, or who are sensitive to thiazide-induced urate rises<\/strong>.<\/p>\n \u03a3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 ARB+HCTZ:<\/strong> \u03a4\u03bf \u039c\u03b5\u03bb\u03ad\u03c4\u03b7 LIFE (2002)<\/strong> used losartan with HCTZ add-on as its active arm, demonstrating a 13% reduction in stroke, cardiovascular death, and myocardial infarction versus atenolol-based therapy in hypertensive patients with left-ventricular hypertrophy. RENAAL (2001) established renoprotection in type 2 diabetic nephropathy.<\/p>\n \u03a4\u03c5\u03c0\u03b9\u03ba\u03ae \u03b4\u03cc\u03c3\u03b7:<\/strong> one 50\/12.5 mg tablet once daily, typically in the morning (HCTZ causes a mild diuresis; evening dosing can disrupt sleep with night-time urination).<\/p>\n When to start Cosart H:<\/strong><\/p>\n \u03a0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03b4\u03cc\u03c3\u03b7\u03c2:<\/strong> \u03b5\u03ac\u03bd \u03b7 \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03af\u03b5\u03c3\u03b7 \u03c0\u03b1\u03c1\u03b1\u03bc\u03b5\u03af\u03bd\u03b5\u03b9 \u03b1\u03bd\u03b5\u03be\u03ad\u03bb\u03b9\u03ba\u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc 4-6 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03b8\u03b5\u03af \u03bc\u03b5 \u03ad\u03bd\u03b1 \u03b4\u03b9\u03c3\u03ba\u03af\u03bf \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae\u03c2 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7\u03c2 \u03b9\u03c3\u03c7\u03cd\u03bf\u03c2 (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03b9 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03b1\u03c1\u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03cd\u03c2 50\/12.5, 100\/12.5, 80\/12.5, 160\/12.5 \u03ba\u03b1\u03b9 160\/25 \u03c4\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd ARB \u03bc\u03b5 HCTZ). \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac, \u03c0\u03c1\u03bf\u03c3\u03b8\u03ad\u03c3\u03c4\u03b5 \u03bc\u03b9\u03b1 \u03c4\u03c1\u03af\u03c4\u03b7 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u2014 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03ad\u03bd\u03b1 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 \u03ba\u03b1\u03bd\u03b1\u03bb\u03b9\u03bf\u03cd \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5 (\u03b1\u03bc\u03bf\u03bb\u03bf\u03b4\u03b9\u03c0\u03af\u03bd\u03b7)<\/a>.<\/p>\n \u03a0\u03c1\u03cc\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2:<\/strong><\/p>\n \u0394\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae:<\/strong> \u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7\u03c2, \u03b1\u03bb\u03bb\u03ac \u03b7 \u03b1\u03c0\u03cc\u03c4\u03bf\u03bc\u03b7 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03c3\u03c4\u03b1\u03b4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03ac\u03ba\u03b1\u03bc\u03c8\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2. \u039c\u03b5\u03b9\u03ce\u03c3\u03c4\u03b5 \u03c3\u03c4\u03b1\u03b4\u03b9\u03b1\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ce\u03bd\u03c4\u03b1\u03c2 \u03bc\u03b5 \u03ad\u03bd\u03b1\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7\u03c2 \u03b9\u03c3\u03c7\u03cd\u03bf\u03c2 \u03ae \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03ad\u03c6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c3\u03c4\u03b7 \u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 ARB \u03c5\u03c0\u03cc \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2.<\/p>\n \u039f\u03b9 \u03c0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03b5\u03c0\u03b9\u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03b4\u03cd\u03bf \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd. \u039f \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03b1\u03bd\u03b5\u03ba\u03c4\u03cc\u03c2<\/strong> \u03b1\u03c0\u03cc \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03c3\u03b5 \u03bc\u03ad\u03b3\u03b9\u03c3\u03c4\u03b7 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2, \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03bf\u03b9 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03bf\u03cd\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03cd\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03bc\u03ad\u03b3\u03b9\u03c3\u03c4\u03b5\u03c2 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b5\u03c2 \u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2.<\/p>\n \u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 (>1% \u03c4\u03c9\u03bd \u03c7\u03c1\u03b7\u03c3\u03c4\u03ce\u03bd):<\/strong><\/p>\n \u03a3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b1\u03bb\u03bb\u03ac \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac:<\/strong><\/p>\n \u0398\u03b7\u03bb\u03b1\u03c3\u03bc\u03cc\u03c2:<\/strong> \u03a4\u03bf HCTZ \u03b5\u03ba\u03ba\u03c1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b3\u03ac\u03bb\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b5\u03af\u03bb\u03b5\u03b9 \u03c4\u03b7 \u03b3\u03b1\u03bb\u03bf\u03c5\u03c7\u03af\u03b1 \u03c3\u03b5 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2\u00b7 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c6\u03b5\u03cd\u03b3\u03b5\u03c4\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03c0\u03c1\u03ce\u03c4\u03b5\u03c2 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03b3\u03ad\u03bd\u03bd\u03b7\u03c3\u03b7 \u03c0\u03c1\u03cc\u03c9\u03c1\u03bf\u03c5 \u03bd\u03b5\u03bf\u03b3\u03bd\u03bf\u03cd. \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03ac (\u03c0\u03c1\u03bf\u03c0\u03c1\u03b1\u03bd\u03cc\u03bb\u03bf\u03bb\u03b7, \u03bd\u03b9\u03c6\u03b5\u03b4\u03af\u03c0\u03bd\u03b7) \u03c0\u03c1\u03bf\u03c4\u03b9\u03bc\u03ce\u03bd\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03bd.<\/p>\n Cosart H is a \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03b2\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2-2<\/strong>, \u03cc\u03c7\u03b9 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03c0\u03c1\u03ce\u03c4\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2. \u0393\u03b9\u03b1 \u03bd\u03ad\u03b1 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ad\u03c2:<\/p>\n Patients with uncomplicated stage 2 hypertension (≥160\/100) may reasonably start directly on Cosart H — current AHA\/ACC guidelines prefer early two-drug initiation for severe hypertension over single-drug titration.<\/p>\n Store Cosart H below 25°C in the original blister pack. Keep out of reach of children.<\/p>\n \u038c\u03c7\u03b9 \u2014 \u03bf\u03b9 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03af \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2 ARB\/\u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2<\/strong>. \u0397 \u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03be\u03b5\u03ba\u03b9\u03bd\u03ae\u03c3\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 ARB (Losar<\/a> (losartan monotherapy)), titrate to target dose, and move to Cosart H only if BP is not controlled after 4-6 weeks. An exception: stage 2 hypertension (≥160\/100) can reasonably start on two-drug therapy directly per AHA\/ACC guidelines.<\/p>\n \u03a0\u03c1\u03c9\u03af<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c0\u03c1\u03bf\u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03b7 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae. \u03a4\u03bf \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc HCTZ \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03cc \u2014 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03bf\u03cd\u03c1\u03c9\u03bd \u03b3\u03b9\u03b1 2-4 \u03ce\u03c1\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03bb\u03ae\u03c8\u03b7. \u0397 \u03bb\u03ae\u03c8\u03b7 \u03c4\u03bf \u03b2\u03c1\u03ac\u03b4\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03ac\u03be\u03b5\u03b9 \u03c4\u03bf\u03bd \u03cd\u03c0\u03bd\u03bf \u03bb\u03cc\u03b3\u03c9 \u03bd\u03c5\u03c7\u03c4\u03b5\u03c1\u03b9\u03bd\u03bf\u03cd \u03bf\u03cd\u03c1\u03b7\u03c3\u03b7\u03c2. \u039f\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03bd\u03c5\u03c7\u03c4\u03b5\u03c1\u03b9\u03bd\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 (\u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c0\u03c4\u03ce\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2 \u03c4\u03b7 \u03bd\u03cd\u03c7\u03c4\u03b1, \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf\u03c2) \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b1\u03bb\u03bb\u03ac\u03be\u03bf\u03c5\u03bd \u03c3\u03b5 \u03bb\u03ae\u03c8\u03b7 \u03c4\u03bf \u03b2\u03c1\u03ac\u03b4\u03c5 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03c3\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03b9\u03bd\u03ae \u03c0\u03af\u03b5\u03c3\u03b7 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2\u00b7 \u03c3\u03c5\u03b6\u03b7\u03c4\u03ae\u03c3\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc \u03c3\u03b1\u03c2.<\/p>\n \u03a0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 5-10 mmHg \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03c3\u03c5\u03c3\u03c4\u03bf\u03bb\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 3-6 mmHg \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03b4\u03b9\u03b1\u03c3\u03c4\u03bf\u03bb\u03b9\u03ba\u03ae<\/strong> on average, measured 4-6 weeks after starting Cosart H. The additive effect comes from blocking the compensatory RAAS activation that normally blunts thiazide monotherapy; that blockade unlocks HCTZ’s full effect.<\/p>\n \u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 \u03c4\u03c9\u03bd \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03af\u03c9\u03bd. \u0397 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03ba\u03b1\u03bb\u03af\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5\u03c1\u03b9\u03ba\u03ce\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03b1\u03b8\u03bc\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c4\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd ARB \u03bd\u03b1 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf \u03ba\u03ac\u03bb\u03b9\u03bf<\/strong>. A small number of patients do develop hypokalaemia — baseline and 1-2 week follow-up U&E is routine. If potassium drops below 3.5, add a potassium-sparing strategy (eplerenone, a potassium-rich diet, or occasionally potassium supplementation) rather than stopping Cosart H.<\/p>\n Losartan uniquely \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9<\/strong> serum uric acid by inhibiting URAT1 in the proximal tubule, which partially offsets<\/strong> HCTZ’s urate-raising effect. Losartan + HCTZ is the preferred ARB+thiazide combination for patients with gout or hyperuricaemia<\/strong>. New-onset gout on Cosart H is uncommon but possible in high-risk patients (CKD, male, alcohol, obesity).<\/p>\n \u039d\u03b1\u03b9, \u03b1\u03bb\u03bb\u03ac \u03bd\u03b1 \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03c4\u03b5 \u03cc\u03c4\u03b9 \u03bf\u03b9 \u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b5\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b5\u03b9\u03bd\u03ce\u03bd\u03bf\u03c5\u03bd \u03bc\u03ad\u03c4\u03c1\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c7\u03ae \u03c3\u03c4\u03b7 \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7<\/strong> (average fasting-glucose rise 5-8 mg\/dL, HbA1c rise 0.1-0.3%). The BP benefit outweighs this effect in most diabetics, and tighter BP control reduces diabetic kidney and eye complications more than the glucose rise increases them. Monitor HbA1c annually. If diabetic control worsens on Cosart H, ask about switching to Telma H<\/a> (\u03c4\u03b5\u03bb\u03bc\u03b9\u03c3\u03b1\u03c1\u03c4\u03ac\u03bd\u03b7 + HCTZ), \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03c1\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7.<\/p>\n \u0397 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c4\u03b1\u03c3\u03b9\u03b1\u03ba\u03ae \u03b2\u03c1\u03b1\u03c7\u03c5\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b1\u03c3\u03c6\u03b1\u03bb\u03ae\u03c2. \u0397 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03c7\u03c1\u03ae\u03c3\u03b7 NSAIDs<\/strong> (\u03b9\u03b2\u03bf\u03c5\u03c0\u03c1\u03bf\u03c6\u03b1\u03af\u03bd\u03b7, \u03b4\u03b9\u03c7\u03bb\u03bf\u03c6\u03b1\u03b9\u03bd\u03ac\u03ba\u03b7, \u03bd\u03b1\u03c0\u03c1\u03bf\u03be\u03ad\u03bd\u03b7) \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03b9\u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03b7 \u03c3\u03b5 \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc ARB + \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u2014 \u03c4\u03bf \u201c\u03c4\u03c1\u03b9\u03c0\u03bb\u03cc \u03c7\u03c4\u03cd\u03c0\u03b7\u03bc\u03b1\u201d (ARB + \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03cc + NSAID) \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03b5\u03b9 \u03bf\u03be\u03b5\u03af\u03b1 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b2\u03bb\u03ac\u03b2\u03b7 \u03c3\u03b5 \u03b1\u03c6\u03c5\u03b4\u03ac\u03c4\u03c9\u03c3\u03b7, \u03bb\u03bf\u03af\u03bc\u03c9\u03be\u03b7 \u03ae \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae \u03b5\u03c0\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7. \u0393\u03b9\u03b1 \u03c7\u03c1\u03cc\u03bd\u03b9\u03bf \u03c0\u03cc\u03bd\u03bf \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03c4\u03b5 \u03c0\u03b1\u03c1\u03b1\u03ba\u03b5\u03c4\u03b1\u03bc\u03cc\u03bb\u03b7\u00b7 \u03b3\u03b9\u03b1 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae \u03c3\u03c5\u03b6\u03b7\u03c4\u03ae\u03c3\u03c4\u03b5 \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc \u03c3\u03b1\u03c2.<\/p>\n \u038c\u03c7\u03b9 \u2014 \u03b1\u03c0\u03bf\u03bb\u03cd\u03c4\u03c9\u03c2 \u03b1\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03b5\u03c4\u03b1\u03b9.<\/strong> \u039a\u03b1\u03b9 \u03c4\u03b1 \u03b4\u03cd\u03bf \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b5\u03c1\u03b1\u03c4\u03bf\u03b3\u03cc\u03bd\u03b1: \u03c4\u03bf ARB \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b1\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03bf\u03bb\u03b9\u03b3\u03bf\u03c5\u03b4\u03c1\u03cc\u03b1\u03bc\u03bd\u03b9\u03bf \u03c3\u03c4\u03bf \u03ad\u03bc\u03b2\u03c1\u03c5\u03bf\u00b7 \u03c4\u03bf HCTZ \u03b4\u03b9\u03b1\u03c0\u03b5\u03c1\u03bd\u03ac \u03c4\u03bf\u03bd \u03c0\u03bb\u03b1\u03ba\u03bf\u03cd\u03bd\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03b5\u03b9 \u03af\u03ba\u03c4\u03b5\u03c1\u03bf \u03ba\u03b1\u03b9 \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03c0\u03b5\u03bd\u03af\u03b1 \u03c3\u03c4\u03bf \u03ad\u03bc\u03b2\u03c1\u03c5\u03bf \u03ae \u03c4\u03bf \u03bd\u03b5\u03bf\u03b3\u03bd\u03cc. \u039f\u03b9 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03c3\u03b5 \u03b1\u03bd\u03b1\u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03b9\u03ba\u03ae \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03b1\u03be\u03b9\u03cc\u03c0\u03b9\u03c3\u03c4\u03b7 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7. \u0393\u03b9\u03b1 \u03cc\u03c3\u03b5\u03c2 \u03c3\u03c7\u03b5\u03b4\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7, \u03b1\u03bb\u03bb\u03ac\u03be\u03c4\u03b5 \u03c3\u03b5 \u03bb\u03b1\u03b2\u03b5\u03c4\u03b1\u03bb\u03cc\u03bb\u03b7<\/a>, \u03bc\u03b5\u03b8\u03c5\u03bb\u03b4\u03cc\u03c0\u03b1 \u03ae \u03bd\u03b9\u03c6\u03b5\u03b4\u03af\u03c0\u03b9\u03bd\u03b7 \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7 \u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7<\/strong>.<\/p>\n \u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03cc\u03c7\u03b9, \u03b1\u03bd \u03c0\u03ac\u03c1\u03b5\u03c4\u03b5 \u03c4\u03bf \u03b4\u03b9\u03c3\u03ba\u03af\u03bf \u03c4\u03bf \u03c0\u03c1\u03c9\u03af. \u0397 \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03ba\u03bf\u03c1\u03c5\u03c6\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 2-4 \u03ce\u03c1\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03bb\u03ae\u03c8\u03b7 \u03ba\u03b1\u03b9 \u03ad\u03c7\u03b5\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b5\u03be\u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c3\u03b5\u03b9 \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c4\u03bf \u03b2\u03c1\u03ac\u03b4\u03c5. \u039f\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03bb\u03bb\u03ac\u03b6\u03bf\u03c5\u03bd \u03c3\u03b5 \u03b2\u03c1\u03b1\u03b4\u03b9\u03bd\u03ae \u03bb\u03ae\u03c8\u03b7 \u03c3\u03c5\u03c7\u03bd\u03ac \u03b2\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03bd\u03c5\u03ba\u03c4\u03bf\u03c5\u03c1\u03af\u03b1\u00b7 \u03b7 \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03b9\u03bd\u03ae \u03bb\u03ae\u03c8\u03b7 \u03b5\u03c0\u03b9\u03bb\u03cd\u03b5\u03b9 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03c0\u03c1\u03cc\u03b2\u03bb\u03b7\u03bc\u03b1 \u03b5\u03bd\u03c4\u03cc\u03c2 1-3 \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd.<\/p>\n \u03a0\u03ac\u03c1\u03c4\u03b5 \u03c4\u03bf \u03bc\u03cc\u03bb\u03b9\u03c2 \u03c4\u03bf \u03b8\u03c5\u03bc\u03b7\u03b8\u03b5\u03af\u03c4\u03b5, \u03b5\u03ba\u03c4\u03cc\u03c2 \u03b1\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03ad\u03c3\u03b1 \u03c3\u03b5 \u03bb\u03af\u03b3\u03b5\u03c2 \u03ce\u03c1\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03c3\u03b1\u03c2 \u2014 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ae\u03bd \u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c0\u03b1\u03c1\u03b1\u03bb\u03b5\u03af\u03c8\u03c4\u03b5 \u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03c7\u03ac\u03c3\u03b1\u03c4\u03b5 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03c3\u03c4\u03b5 \u03c4\u03bf \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03cc \u03c3\u03b1\u03c2 \u03c0\u03c1\u03cc\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1. \u039c\u03b7\u03bd \u03c0\u03ac\u03c1\u03b5\u03c4\u03b5 \u03b4\u03b9\u03c0\u03bb\u03ae \u03b4\u03cc\u03c3\u03b7. \u039c\u03af\u03b1 \u03bc\u03cc\u03bd\u03bf \u03b4\u03cc\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03c7\u03ac\u03b8\u03b7\u03ba\u03b5 \u03b4\u03b5\u03bd \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c4\u03b7\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2. \u0395\u03ac\u03bd \u03c7\u03ac\u03c3\u03b5\u03c4\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1\u03c0\u03cc 2 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2, \u03b7 \u03c0\u03af\u03b5\u03c3\u03ae \u03c3\u03b1\u03c2 \u03b8\u03b1 \u03b1\u03c1\u03c7\u03af\u03c3\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03be\u03b1\u03bd\u03ac\u00b7 \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03c3\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03c3\u03b1\u03c2 (\u03b4\u03b5\u03bd \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03c5\u03be\u03ae\u03c3\u03b5\u03c4\u03b5 \u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7).<\/p>\n You can buy Cosart H (50\/12.5 mg losartan + HCTZ, 30-180 tablets) from MedsBase with discreet packaging and worldwide shipping.<\/p>\n <\/p>\n \u0386\u03bb\u03bb\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 \u03c3\u03b5 \u03a7\u03c1\u03cc\u03bd\u03b9\u03b5\u03c2 \u03a0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2<\/strong> \u03c0\u03bf\u03c5 \u03bf\u03b9 \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2:<\/p>\n Cosart H is Abbott’s fixed-dose losartan 50 mg + HCTZ 12.5 mg tablets \u2014 step-2 antihypertensive combination for patients not controlled on losartan monotherapy. Losartan is uniquely uricosuric among ARBs, partially offsetting HCTZ’s urate-raising effect \u2014 the preferred ARB+thiazide combination in hypertension with gout or hyperuricaemia. LIFE trial used this combination.<\/p>","protected":false},"featured_media":58242,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3342,3260,3356],"product_tag":[4450,3401,4447],"class_list":{"0":"post-58241","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-general-health","9":"product_cat-heart-blood-pressure","10":"product_cat-high-blood-pressure-medication","11":"product_tag-cosart-h","12":"product_tag-hydrochlorothiazide","13":"product_tag-losartan-potassium","15":"first","16":"instock","17":"shipping-taxable","18":"purchasable","19":"product-type-variable","20":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/58241","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=58241"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/58242"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=58241"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=58241"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=58241"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=58241"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n
What Is Cosart H?<\/h2>\n
\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03c3\u03b5\u03c4\u03b5 \u03ad\u03bd\u03b1 ARB \u03bc\u03b5 \u03ad\u03bd\u03b1 \u03b8\u03b5\u03b9\u03b1\u03b6\u03b9\u03b4\u03b9\u03ba\u03cc;<\/h2>\n
\n
\u0394\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 & \u03a4\u03b9\u03c4\u03bb\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7<\/h2>\n
\n
\n
\u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/h2>\n
\n
\n
\u0391\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/h2>\n
\n
\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03a6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd<\/h2>\n
\n
Cosart H vs ARB Monotherapy — When to Step Up<\/h2>\n
\n
\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7<\/h2>\n
\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n
Is Cosart H a first-line blood-pressure drug?<\/h3>\n
When should I take Cosart H — morning or evening?<\/h3>\n
\u03a0\u03cc\u03c3\u03b7 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03bc\u03c0\u03bf\u03c1\u03ce \u03bd\u03b1 \u03b1\u03bd\u03b1\u03bc\u03ad\u03bd\u03c9 \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd Losar<\/a> (losartan monotherapy) alone?<\/h3>\n
My potassium is normal on an ARB — will it drop on Cosart H?<\/h3>\n
Will Cosart H raise my uric acid or trigger gout?<\/h3>\n
I have type 2 diabetes — is Cosart H safe?<\/h3>\n
Can I take ibuprofen with Cosart H?<\/h3>\n
Can I take Cosart H in pregnancy?<\/h3>\n
Will I need to urinate more at night on Cosart H?<\/h3>\n
\u03a4\u03b9 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03bd \u03c7\u03ac\u03c3\u03c9 \u03bc\u03b9\u03b1 \u03b4\u03cc\u03c3\u03b7;<\/h3>\n
Where can I buy Cosart H online?<\/h3>\n
\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u0391\u03bd\u03c4\u03b9\u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf MedsBase<\/h2>\n
\n
\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2<\/h3>\n
\n