{"id":58759,"date":"2024-02-28T05:27:04","date_gmt":"2024-02-28T05:27:04","guid":{"rendered":"https:\/\/medsname.com\/admenta\/"},"modified":"2026-05-01T10:49:14","modified_gmt":"2026-05-01T10:49:14","slug":"admenta","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/admenta\/","title":{"rendered":"\u0391\u03bd\u03c4\u03bc\u03ad\u03bd\u03c4\u03b1"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Admenta?<\/h3>\n<p style=\"margin:0;\"><strong>\u0391\u03bd\u03c4\u03bc\u03ad\u03bd\u03c4\u03b1<\/strong> is an oral tablet from Sun Pharma containing <strong>memantine 5 mg<\/strong> &mdash; an <strong>uncompetitive NMDA receptor antagonist<\/strong> used for the symptomatic treatment of <strong>moderate-to-severe Alzheimer&#39;s disease<\/strong>. Memantine is <strong>\u03b4\u03b5\u03bd<\/strong> indicated for mild Alzheimer&#39;s. Slow upward titration over 4 weeks: <strong>5 mg week 1, 10 mg week 2 (5 mg twice daily), 15 mg week 3, 20 mg week 4 onwards (10 mg twice daily)<\/strong>. Generally well tolerated &mdash; main side effects are dizziness, headache, constipation and confusion. <strong>Reduce dose if eGFR &lt; 30 mL\/min<\/strong>. Often combined with donepezil in moderate-to-severe disease for additive cognitive benefit.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong> \u03a0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2 WHO-GMP \u00b7 \u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u00b7 \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u00b7 1,400+ \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 <a href=\"https:\/\/medsbase.com\/el\/reviews\/\">\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\"><strong>\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n<h3>\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n<p>\u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n<h2 class=\"wp-block-heading\">What Is Admenta?<\/h2>\n<p>Admenta is an oral tablet from Sun Pharma containing <strong>memantine hydrochloride 5 mg<\/strong>. Memantine is a low-affinity, voltage-dependent, uncompetitive antagonist of the <strong>N-methyl-D-aspartate (NMDA) glutamate receptor<\/strong>. It is mechanistically distinct from the cholinesterase inhibitors (donepezil, galantamine, rivastigmine) and works through the second major pathway implicated in Alzheimer&#39;s disease &mdash; glutamate excitotoxicity.<\/p>\n<p>Admenta from Sun Pharma is a 5 mg memantine tablet &mdash; the strength used during the mandatory 4-week up-titration to the 20 mg\/day maintenance dose. Maintenance dosing is two 5 mg tablets twice daily (4 tablets total per day). Memantine is licensed only for <strong>moderate-to-severe Alzheimer&#39;s disease<\/strong> &mdash; not mild. It is the standard add-on to a cholinesterase inhibitor (typically donepezil) when patients progress past the mild stage, and produces additive cognitive and functional benefit with minimal increase in side effects.<\/p>\n<h2 class=\"wp-block-heading\">How Does Admenta Work?<\/h2>\n<p>Alzheimer&#39;s disease causes chronic excessive glutamate signalling at NMDA receptors &mdash; a process called <strong>glutamate excitotoxicity<\/strong>. Constant low-level NMDA activation damages neurons and disrupts the signal-to-noise ratio that the brain needs for learning and memory. Memantine addresses this through a unique mechanism:<\/p>\n<ul>\n<li><strong>Voltage-dependent NMDA blockade<\/strong> &mdash; memantine binds to NMDA receptor channels but only when they are already open. It blocks chronic low-level excitotoxic activation but releases the receptor during high-amplitude physiological signalling needed for learning. This is the key difference between memantine and older NMDA blockers like ketamine, which block both modes and cause cognitive impairment.<\/li>\n<li><strong>Restores signal-to-noise ratio<\/strong> &mdash; by reducing background glutamate noise, memantine improves the brain&#39;s ability to detect meaningful signals during learning and memory tasks.<\/li>\n<li><strong>Neuroprotective effect<\/strong> &mdash; reduced excitotoxicity may slow the progression of neuronal damage, though this has not been definitively shown to translate into a clinically meaningful disease-modifying effect.<\/li>\n<\/ul>\n<p>Onset of cognitive benefit: visible at <strong>4&ndash;12 weeks<\/strong> after reaching the maintenance 20 mg\/day dose; peak benefit at 6 months.<\/p>\n<h2 class=\"wp-block-heading\">\u03a7\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li><strong>Moderate-to-severe Alzheimer&#39;s dementia<\/strong> &mdash; first-line indication<\/li>\n<li><strong>Combination therapy with a cholinesterase inhibitor<\/strong> &mdash; standard of care in moderate-to-severe Alzheimer&#39;s; additive cognitive benefit<\/li>\n<li><strong>Vascular dementia (mixed type)<\/strong> &mdash; off-label modest benefit<\/li>\n<li><strong>Dementia with Lewy bodies<\/strong> &mdash; off-label, useful for behavioural symptoms<\/li>\n<\/ul>\n<p>Admenta is <strong>\u03b4\u03b5\u03bd<\/strong> indicated for: <strong>mild Alzheimer&#39;s disease<\/strong> (cholinesterase inhibitors are first-line at this stage), mild cognitive impairment without dementia, frontotemporal dementia, or as a cognitive enhancer in healthy adults.<\/p>\n<h2 class=\"wp-block-heading\">Admenta Dosage and How to Take &mdash; SLOW TITRATION<\/h2>\n<p>Admenta comes at <strong>5 mg<\/strong> tablets. The titration schedule is mandatory &mdash; jumping straight to 20 mg\/day causes intolerable confusion and dizziness in most patients.<\/p>\n<p><strong>Standard 4-week titration:<\/strong><\/p>\n<ul>\n<li><strong>Week 1:<\/strong> 5 mg once daily (1 tablet morning)<\/li>\n<li><strong>Week 2:<\/strong> 10 mg\/day = 5 mg twice daily (morning + evening)<\/li>\n<li><strong>Week 3:<\/strong> 15 mg\/day = 10 mg morning + 5 mg evening<\/li>\n<li><strong>Week 4 onward (maintenance):<\/strong> 20 mg\/day = 10 mg twice daily<\/li>\n<\/ul>\n<h3 class=\"wp-block-heading\">How to Take Admenta Properly<\/h3>\n<ol>\n<li><strong>Take with or without food<\/strong> &mdash; food does not affect absorption.<\/li>\n<li><strong>\u039a\u03b1\u03c4\u03b1\u03c0\u03b9\u03b5\u03af\u03c4\u03b5 \u03bf\u03bb\u03cc\u03ba\u03bb\u03b7\u03c1\u03bf \u03bc\u03b5 \u03bd\u03b5\u03c1\u03cc.<\/strong> Standard tablets can be split if scored.<\/li>\n<li><strong>Twice daily at maintenance dose<\/strong> (10 mg morning + 10 mg evening), spaced about 12 hours apart.<\/li>\n<li><strong>Renal dose adjustment:<\/strong> if estimated GFR is 30&ndash;49 mL\/min, cap maintenance dose at 10 mg\/day. If eGFR is 5&ndash;29 mL\/min, maintenance dose is 10 mg\/day. Avoid in eGFR &lt; 5 mL\/min.<\/li>\n<li><strong>Missed dose:<\/strong> if remembered the same day, take it. If remembered the next day, skip and resume normally &mdash; do not double-dose.<\/li>\n<li><strong>If treatment is interrupted for more than a few days<\/strong>, restart at 5 mg\/day and re-titrate over 4 weeks. Memantine has no acute discontinuation syndrome but the slow titration is needed to avoid side effects.<\/li>\n<li><strong>Caregiver supervision is critical<\/strong> &mdash; patients with moderate-severe Alzheimer&#39;s rarely manage twice-daily dosing reliably without support. Use a weekly pill organiser filled by a family member or carer.<\/li>\n<li><strong>Re-assess after 6 months<\/strong> with formal cognitive testing (MMSE or MoCA). Continue if there is benefit or stabilisation; stop gradually if clear deterioration despite full-dose treatment.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Side Effects of Admenta<\/h2>\n<p><strong>Common (worst during titration, settle once on maintenance):<\/strong><\/p>\n<ul>\n<li>\u0396\u03ac\u03bb\u03b7<\/li>\n<li>\u039a\u03b5\u03c6\u03b1\u03bb\u03b1\u03bb\u03b3\u03af\u03b1<\/li>\n<li>Confusion or worsening confusion (often improves once on stable maintenance dose)<\/li>\n<li>\u0394\u03c5\u03c3\u03ba\u03bf\u03b9\u03bb\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1<\/li>\n<li>Sleepiness or fatigue<\/li>\n<li>Hypertension (mild rise in BP)<\/li>\n<\/ul>\n<p><strong>\u039b\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03c5\u03c7\u03bd\u03ad\u03c2:<\/strong><\/p>\n<ul>\n<li>Hallucinations or worsening of existing hallucinations<\/li>\n<li>Agitation or aggression (paradoxical, especially during titration)<\/li>\n<li>Falls (from dizziness)<\/li>\n<li>Urinary tract infections<\/li>\n<\/ul>\n<p><strong>Rare but seek medical review:<\/strong><\/p>\n<ul>\n<li>Seizures<\/li>\n<li>Severe psychiatric symptoms (psychosis, mania)<\/li>\n<li>\u03a0\u03b1\u03b3\u03ba\u03c1\u03b5\u03b1\u03c4\u03af\u03c4\u03b9\u03b4\u03b1<\/li>\n<li>\u0397\u03c0\u03b1\u03c4\u03af\u03c4\u03b9\u03b4\u03b1<\/li>\n<li>Stevens-Johnson syndrome (case reports)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u03a0\u03c1\u03bf\u03b5\u03b9\u03b4\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03ac\u03be\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li><strong>\u039d\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1:<\/strong> dose reduction is mandatory. Cap at 10 mg\/day if eGFR 5&ndash;49 mL\/min. Avoid if eGFR &lt; 5 mL\/min. Memantine accumulates in renal failure and causes toxicity.<\/li>\n<li><strong>Urinary alkalisation:<\/strong> conditions that raise urine pH (severe UTI, renal tubular acidosis, vegetarian diet with high-dose alkalinising drugs, sodium bicarbonate) reduce memantine clearance and raise blood levels &mdash; monitor for side effects.<\/li>\n<li><strong>Seizure history:<\/strong> use cautiously &mdash; memantine may lower seizure threshold.<\/li>\n<li><strong>Recent myocardial infarction, uncontrolled hypertension, severe heart failure:<\/strong> caution &mdash; not enough safety data in these populations.<\/li>\n<li><strong>\u0397\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1:<\/strong> no dose adjustment for mild-moderate; caution in severe.<\/li>\n<li><strong>Hallucinations and delusions:<\/strong> can worsen pre-existing psychiatric symptoms in some patients with dementia. Monitor for behavioural changes.<\/li>\n<li><strong>Caregiver support:<\/strong> patients in the moderate-severe Alzheimer&#39;s population for whom memantine is indicated rarely manage their own medication. Caregiver involvement in dose preparation, supervision and adherence is essential.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Contraindications &mdash; Who Should NOT Take Admenta<\/h2>\n<ul>\n<li>Known hypersensitivity to memantine or any tablet excipient<\/li>\n<li>Severe renal impairment (eGFR &lt; 5 mL\/min)<\/li>\n<li>Mild Alzheimer&#39;s dementia (use a cholinesterase inhibitor first)<\/li>\n<li>Mild cognitive impairment without dementia<\/li>\n<li>Frontotemporal dementia (no benefit and may worsen behavioural symptoms)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03a6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u03a3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u0391\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u03a4\u03b9 \u03bd\u03b1 \u03ba\u03ac\u03bd\u03b5\u03c4\u03b5<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Other NMDA antagonists (amantadine, ketamine, dextromethorphan)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Additive psychotomimetic effects (confusion, hallucinations, dissociation)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Avoid combination. Tell anaesthetist about memantine before any procedure involving ketamine.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Cholinesterase inhibitors (donepezil, galantamine, rivastigmine)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Standard combination &mdash; additive cognitive benefit, no significant interaction<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Standard add-on therapy in moderate-severe Alzheimer&#39;s. See <a href=\"https:\/\/medsbase.com\/el\/aricep\/\">Aricep<\/a>.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Hydrochlorothiazide and other thiazide diuretics<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Memantine reduces diuretic effect; thiazide raises memantine levels<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor BP and check for memantine side effects.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Sodium bicarbonate, acetazolamide, urinary alkalisers<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reduce renal clearance of memantine &mdash; raise blood levels<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor for memantine toxicity (confusion, dizziness, sleepiness).<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Levodopa, dopamine agonists (Parkinson&#39;s drugs)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Memantine may potentiate dopaminergic effects<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor for dyskinesias and psychiatric side effects.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Barbiturates, neuroleptics (antipsychotics)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Memantine may reduce their effect<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor symptom control; titrate as needed.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0392\u03b1\u03c1\u03c6\u03b1\u03c1\u03af\u03bd\u03b7<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Some case reports of raised INR with combination<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Check INR more frequently after starting memantine.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">\u039f\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7\u03c2<\/h2>\n<ul>\n<li>\u03a6\u03c5\u03bb\u03ac\u03be\u03c4\u03b5 \u03c3\u03b5 \u03b8\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03af\u03b1 \u03b4\u03c9\u03bc\u03b1\u03c4\u03af\u03bf\u03c5, <strong>15\u201325\u00b0C<\/strong>. Protect from light and moisture.<\/li>\n<li>Keep tablets in the original blister pack until use.<\/li>\n<li>Do not store in the bathroom &mdash; humidity shortens shelf life.<\/li>\n<li>Keep out of reach of children and patients who may not understand they are medication.<\/li>\n<li>\u039c\u03b7\u03bd \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b5 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03b7\u03bc\u03b5\u03c1\u03bf\u03bc\u03b7\u03bd\u03af\u03b1 \u03bb\u03ae\u03be\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03b3\u03c1\u03ac\u03c6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1.<\/li>\n<li>Return unused tablets to a pharmacy for disposal.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u039b\u03cd\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf MedsBase<\/h2>\n<p>Other Alzheimer&#39;s and dementia medications stocked on MedsBase:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/aricep\/\"><strong>Aricep (donepezil 5 \/ 10 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/donect\/\"><strong>Donect (donepezil 10 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/donemax\/\"><strong>Donemax (donepezil 10 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/galamer\/\"><strong>Galamer (galantamine 4 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/rivamer-2\/\"><strong>Rivamer (rivastigmine 1.5 mg)<\/strong><\/a><\/li>\n<\/ul>\n<p>\u03a7\u03c1\u03ae\u03c3\u03b9\u03bc\u03b7 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7: <a href=\"https:\/\/medsbase.com\/el\/everything-you-need-to-know-about-alzheimers-disease\/\">Everything you need to know about Alzheimer&#39;s disease<\/a> \u00b7 <a href=\"https:\/\/medsbase.com\/el\/everything-to-know-about-dementia\/\">Everything to know about dementia<\/a> \u00b7 <a href=\"https:\/\/medsbase.com\/el\/7-ways-to-protect-your-brain-health-as-you-age\/\">7 ways to protect your brain health as you age<\/a> \u00b7 <a href=\"https:\/\/medsbase.com\/el\/best-foods-for-a-healthy-brain-and-improved-memory\/\">Best foods for a healthy brain and improved memory<\/a>.<\/p>\n<h2 id=\"faqs\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3 class=\"wp-block-heading\">Why is Admenta only for moderate-to-severe Alzheimer&#39;s?<\/h3>\n<p>Trials show no clinically meaningful cognitive benefit from memantine in mild Alzheimer&#39;s &mdash; the glutamate excitotoxicity pathway becomes a dominant driver of symptoms only later in the disease. For mild Alzheimer&#39;s, a cholinesterase inhibitor (donepezil, galantamine, rivastigmine) is first-line. Memantine is added when the patient progresses to moderate or severe disease.<\/p>\n<h3 class=\"wp-block-heading\">Can Admenta be combined with donepezil?<\/h3>\n<p>Yes &mdash; this is the standard combination for <strong>moderate-to-severe Alzheimer&#39;s disease<\/strong>. The two drugs work on different pathways (cholinergic + glutamatergic) and produce additive cognitive and functional benefit. There is no significant pharmacokinetic interaction. Combination therapy is more effective than either drug alone at the moderate-to-severe stage. <a href=\"https:\/\/medsbase.com\/el\/aricep\/\">Aricep (donepezil)<\/a> is the standard partner.<\/p>\n<h3 class=\"wp-block-heading\">Why does Admenta need a 4-week titration?<\/h3>\n<p>Jumping to the 20 mg\/day maintenance dose on day one causes intolerable confusion, dizziness and sometimes hallucinations &mdash; bad enough that most patients discontinue. The 4-week up-titration (5 &rarr; 10 &rarr; 15 &rarr; 20 mg\/day) lets the brain adapt to NMDA blockade gradually. Skipping titration is the most common reason patients &ldquo;cannot tolerate&rdquo; memantine.<\/p>\n<h3 class=\"wp-block-heading\">When will I or my family member see results?<\/h3>\n<p>Visible cognitive benefit at <strong>4&ndash;12 weeks<\/strong> after reaching the 20 mg\/day maintenance dose; peak benefit at 6 months. Like donepezil, memantine is symptomatic therapy, not disease-modifying. Re-assess with formal cognitive testing at 6 months.<\/p>\n<h3 class=\"wp-block-heading\">Does Admenta need dose adjustment for kidney problems?<\/h3>\n<p>Yes. Memantine is renally cleared and accumulates in kidney impairment. Dose caps: <strong>eGFR 30&ndash;49 mL\/min<\/strong> &mdash; cap maintenance at 10 mg\/day. <strong>eGFR 5&ndash;29 mL\/min<\/strong> &mdash; maintenance 10 mg\/day. <strong>eGFR &lt; 5 mL\/min<\/strong> &mdash; avoid memantine entirely. Check kidney function before starting and at any sign of toxicity (confusion, sleepiness, dizziness on a previously stable dose).<\/p>\n<h3 class=\"wp-block-heading\">Is Admenta a cure or does it slow Alzheimer&#39;s progression?<\/h3>\n<p><strong>Neither.<\/strong> Memantine is symptomatic therapy &mdash; it stabilises function for a window of typically 6&ndash;18 months. The underlying neurodegeneration continues. Newer disease-modifying drugs (anti-amyloid antibodies like lecanemab and donanemab) target the underlying pathology but require IV infusion, regular MRI monitoring, and specialist supervision &mdash; they are not stocked here.<\/p>\n<h3 class=\"wp-block-heading\">Does Admenta help with behavioural symptoms (agitation, aggression, hallucinations)?<\/h3>\n<p>Modest benefit on agitation and aggression in moderate-severe Alzheimer&#39;s &mdash; one of the reasons memantine is the preferred add-on at this stage rather than a second cholinesterase inhibitor. Memantine can paradoxically worsen hallucinations in a minority of patients &mdash; monitor and stop if this occurs.<\/p>\n<h3 class=\"wp-block-heading\">Can I stop Admenta if it is not helping?<\/h3>\n<p>Discuss with the prescriber. If formal cognitive testing at 6 months shows no benefit and the patient has progressed clearly, memantine can be stopped. Unlike donepezil, memantine has no significant discontinuation syndrome &mdash; but a gradual taper over 1&ndash;2 weeks is still standard practice.<\/p>\n<h3 class=\"wp-block-heading\">Is Admenta safe with my parent&#39;s blood pressure or heart medications?<\/h3>\n<p>Memantine is generally safe with most cardiovascular medications. There is no significant interaction with beta-blockers, ACE inhibitors, ARBs, calcium channel blockers, statins, or aspirin. Thiazide diuretics may slightly raise memantine levels &mdash; monitor for side effects but no dose adjustment is usually needed. Memantine causes a mild rise in BP in some patients &mdash; check BP at the 6-week and 3-month visits.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2<\/h3>\n<p>\u0386\u03bb\u03bb\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 \u03c3\u03b5 <strong>\u03a7\u03c1\u03cc\u03bd\u03b9\u03b5\u03c2 \u03a0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2<\/strong> \u03c0\u03bf\u03c5 \u03bf\u03b9 \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/duovir-n\/\">Duovir N<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/neomercazole\/\">Neomercazole<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/venish-sr\/\">Venish SR<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/syndopa\/\">Syndopa<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/pregastar\/\">Pregastar 75 mg (Pregabalin) \u2014 Neuropathic Pain &amp; Anxiety<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Enhances cognition<br \/>\n\u2705 Improves memory<br \/>\n\u2705 Slows neurodegeneration<br \/>\n\u2705 Reduces confusion<br \/>\n\u2705 Manages Alzheimer&#8217;s<\/p>\n<p>Admenta contains Memantine.<\/p>","protected":false},"featured_media":58760,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3772,3141,3223],"product_tag":[4562,4563],"class_list":{"0":"post-58759","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-alzheimers-treatment","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-admenta","10":"product_tag-memantine","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/58759","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=58759"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/58760"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=58759"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=58759"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=58759"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=58759"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}