{"id":59484,"date":"2024-02-28T06:00:08","date_gmt":"2024-02-28T06:00:08","guid":{"rendered":"https:\/\/medsname.com\/angiplat\/"},"modified":"2026-05-01T10:49:15","modified_gmt":"2026-05-01T10:49:15","slug":"angiplat","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/angiplat\/","title":{"rendered":"Angiplat"},"content":{"rendered":"

<\/p>\n

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⚡ Quick Answer — What is Angiplat?<\/h3>\n

Angiplat<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 nitroglycerin (glyceryl trinitrate) 2.5 mg sustained-release capsule<\/strong>, used for the prophylaxis<\/em> (prevention) of chronic stable angina pectoris. A usual starting dose is one capsule two to three times a day<\/strong> with an 8–12 hour nitrate-free interval<\/strong> overnight. Angiplat is \u03b4\u03b5\u03bd<\/strong> suitable for aborting an acute angina attack — use sublingual nitroglycerin or isosorbide dinitrate for that purpose.<\/p>\n<\/div>\n

\n\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong> \u03a0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2 WHO-GMP \u00b7 \u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u00b7 \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u00b7 1,400+ \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a>\n<\/div>\n

\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n

\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n

\u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n

Angiplat 2.5 mg<\/strong> is an oral, sustained-release (SR) nitroglycerin capsule manufactured for daily use in patients with chronic stable angina pectoris. Each capsule contains 2.5 mg of glyceryl trinitrate (nitroglycerin)<\/strong> in a controlled-release matrix that slowly releases the active drug over 6–8 hours. This extended release profile allows twice- or thrice-daily dosing rather than the very short action of sublingual nitroglycerin.<\/p>\n

Angiplat is widely prescribed in cardiology practice as part of a long-term anti-anginal regimen — usually alongside a beta-blocker (atenolol, metoprolol, bisoprolol) or a calcium channel blocker (amlodipine, diltiazem), plus aspirin and a statin for secondary prevention of coronary events. It reduces the number and severity of angina episodes, improves exercise tolerance, and can reduce the need for short-acting rescue medication during the day.<\/p>\n

What Is Angiplat Used For?<\/h2>\n

Angiplat is indicated for:<\/p>\n

    \n
  • Long-term prophylaxis of chronic stable angina<\/strong> — reducing the frequency of chest pain episodes<\/li>\n
  • Effort-induced angina<\/strong> — pre-medication before predictable strain (walking uphill, climbing stairs)<\/li>\n
  • Mixed angina<\/strong> (combination of effort and spasm) — as add-on therapy<\/li>\n
  • Left ventricular failure with angina<\/strong> — reducing preload and ischaemia<\/li>\n<\/ul>\n

    Angiplat is \u03b4\u03b5\u03bd<\/em> indicated for acute angina attacks. Sustained-release oral nitroglycerin has an onset of 30–45 minutes — too slow to abort a live ischaemic episode. For that indication, use a sublingual nitroglycerin tablet or spray, or a sublingual isosorbide dinitrate 5 mg tablet.<\/p>\n

    How Do Nitrates Work?<\/h2>\n

    All nitrate medications share the same basic mechanism. Once absorbed, they are enzymatically converted into \u03bd\u03b9\u03c4\u03c1\u03b9\u03ba\u03cc \u03bf\u03be\u03cd (NO)<\/strong> inside vascular smooth muscle cells. NO activates guanylate cyclase, raising intracellular cGMP and relaxing the smooth muscle of blood vessels. The clinical effects are:<\/p>\n

      \n
    • Venous dilation<\/strong> (dominant at low doses) — reduces venous return to the heart, lowering preload<\/em>. This is how nitrates reduce myocardial oxygen demand.<\/li>\n
    • Arterial dilation<\/strong> (higher doses) — reduces systemic vascular resistance and afterload<\/em>, further cutting cardiac workload.<\/li>\n
    • Coronary artery dilation<\/strong> — improves blood flow to ischaemic regions of the heart muscle, especially in coronary spasm.<\/li>\n<\/ul>\n

      The net effect is less chest pain, fewer angina episodes, and improved exercise tolerance in patients with stable coronary artery disease.<\/p>\n

      Nitrate Tolerance — the Critical Dosing Rule<\/h2>\n

      Nitrate tolerance is the single most important concept for any patient on a nitrate. If a nitrate is given around the clock — at steady blood levels for 24 hours a day — the anti-anginal effect fades within 48 to 72 hours. This is a well-documented, reproducible pharmacological phenomenon, not an imaginary effect.<\/p>\n

      The fix is simple and non-negotiable: every 24-hour cycle must include a nitrate-free interval of at least 8–12 hours<\/strong>, usually overnight. The standard strategies are:<\/p>\n

        \n
      • Asymmetric twice-daily dosing (e.g. 7 a.m. and 3 p.m., nothing after that until the next morning)<\/li>\n
      • Once-daily sustained-release formulations designed to deliver a low trough<\/li>\n
      • Removing a transdermal patch after 12–14 hours on the skin<\/li>\n<\/ul>\n

        \u039a\u03ac\u03bd\u03c4\u03b5 \u03b4\u03b5\u03bd<\/em> take extra doses “at bedtime” or during the night unless your doctor explicitly prescribes round-the-clock therapy for a specific reason.<\/p>\n

        Angiplat Dosing<\/h2>\n

        For chronic stable angina in adults:<\/p>\n

          \n
        • \u0391\u03c1\u03c7\u03b9\u03ba\u03ae \u03b4\u03cc\u03c3\u03b7:<\/strong> 2.5 mg (one capsule) two to three times daily, with meals<\/li>\n
        • \u03a0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03b4\u03cc\u03c3\u03b7\u03c2:<\/strong> If angina remains uncontrolled after 1–2 weeks, doctors may increase to 5 mg (two capsules) twice or three times daily, or switch to Angispan-TR 6.5 mg<\/li>\n
        • Nitrate-free interval:<\/strong> Leave at least 8–12 hours between the last dose of one day and the first dose of the next. The easiest way: take at 7 a.m. and 3 p.m., then nothing until the following morning<\/li>\n
        • \u039c\u03ad\u03b3\u03b9\u03c3\u03c4\u03bf:<\/strong> 26 mg\/day in divided doses (rarely needed)<\/li>\n<\/ul>\n

          Capsules should be swallowed whole with water; do not crush, chew, or open them — this destroys the sustained-release matrix and causes a rapid burst of nitroglycerin with a bad headache and hypotension.<\/p>\n

          Missed dose: take it as soon as you remember, unless it is within 3 hours of the next scheduled dose — in that case skip the missed dose. Never double up.<\/p>\n

          Who Should Not Take Angiplat?<\/h2>\n

          There is one absolute contraindication that every patient must understand before the first dose:<\/p>\n

          \n

          Never combine any nitrate with a PDE5 inhibitor.<\/strong> Sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra), and avanafil (Stendra) potentiate the vasodilator effect of nitrates and can cause life-threatening hypotension, collapse, stroke, or myocardial infarction. Wait at least 24 hours after sildenafil\/vardenafil<\/strong> \u03ba\u03b1\u03b9 48 hours after tadalafil<\/strong> before taking any nitrate dose. This applies to all forms — oral, sublingual, transdermal, and spray.<\/p>\n<\/div>\n

          Other important contraindications:<\/p>\n