<\/p>\n
Angispan-TR<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 nitroglycerin (glyceryl trinitrate) 6.5 mg time-release capsule<\/strong>, used for daily prophylaxis<\/em> of chronic stable angina. The usual dose is one capsule twice daily<\/strong>, taken 7 hours apart (e.g. 7 a.m. and 2 p.m.) to preserve an 8–12 hour overnight nitrate-free interval<\/strong>. Angispan-TR is \u03b4\u03b5\u03bd<\/strong> a rescue medication for acute attacks — keep sublingual nitroglycerin for that.<\/p>\n<\/div>\n \ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n \u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n Angispan-TR 6.5 mg<\/strong> is a time-release (TR) oral nitroglycerin capsule. “TR” stands for “Time Release” — the capsule is engineered to release its 6.5 mg of glyceryl trinitrate gradually over 6–8 hours, giving steady anti-anginal cover during the active part of the day without the peak-and-trough swings of short-acting nitrates.<\/p>\n Angispan-TR is prescribed across India and Southeast Asia as a mainstream long-term anti-anginal agent, often as the first choice when sublingual rescue doses alone are not enough to keep a patient symptom-free. Typical patients are those with stable coronary artery disease whose chest pain limits their daily activity, who cannot tolerate beta-blocker-only therapy, or who need combination therapy after diagnosis.<\/p>\n Angispan-TR is indicated for:<\/p>\n \u0395\u03af\u03bd\u03b1\u03b9 \u03b4\u03b5\u03bd<\/em> appropriate for an acute episode. Onset is 30–60 minutes, far too slow to abort an ongoing attack. Every patient on Angispan-TR should also carry sublingual nitroglycerin or a sublingual isosorbide dinitrate 5 mg (Sorbitrate) tablet for rescue.<\/p>\n All nitrate medications share the same basic mechanism. Once absorbed, they are enzymatically converted into \u03bd\u03b9\u03c4\u03c1\u03b9\u03ba\u03cc \u03bf\u03be\u03cd (NO)<\/strong> inside vascular smooth muscle cells. NO activates guanylate cyclase, raising intracellular cGMP and relaxing the smooth muscle of blood vessels. The clinical effects are:<\/p>\n The net effect is less chest pain, fewer angina episodes, and improved exercise tolerance in patients with stable coronary artery disease.<\/p>\n Nitrate tolerance is the single most important concept for any patient on a nitrate. If a nitrate is given around the clock — at steady blood levels for 24 hours a day — the anti-anginal effect fades within 48 to 72 hours. This is a well-documented, reproducible pharmacological phenomenon, not an imaginary effect.<\/p>\n The fix is simple and non-negotiable: every 24-hour cycle must include a nitrate-free interval of at least 8–12 hours<\/strong>, usually overnight. The standard strategies are:<\/p>\n \u039a\u03ac\u03bd\u03c4\u03b5 \u03b4\u03b5\u03bd<\/em> take extra doses “at bedtime” or during the night unless your doctor explicitly prescribes round-the-clock therapy for a specific reason.<\/p>\n For chronic stable angina in adults:<\/p>\n If you miss a dose, take it when you remember unless your next dose is due within 3 hours — then skip it. Never double up.<\/p>\n In older patients (over 70), hepatic impairment, or alongside antihypertensives, start at the lowest dose and titrate cautiously; Angispan-TR can drop blood pressure noticeably in these groups.<\/p>\n There is one absolute contraindication that every patient must understand before the first dose:<\/p>\n Never combine any nitrate with a PDE5 inhibitor.<\/strong> Sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra), and avanafil (Stendra) potentiate the vasodilator effect of nitrates and can cause life-threatening hypotension, collapse, stroke, or myocardial infarction. Wait at least 24 hours after sildenafil\/vardenafil<\/strong> \u03ba\u03b1\u03b9 48 hours after tadalafil<\/strong> before taking any nitrate dose. This applies to all forms — oral, sublingual, transdermal, and spray.<\/p>\n<\/div>\n Other important contraindications:<\/p>\n Use with caution in pregnancy (category C) and discuss with a specialist. In breastfeeding, occasional use is generally accepted, but routine therapy should be reviewed with a cardiologist.<\/p>\n Most side effects of nitrates are direct extensions of their vasodilator action and tend to settle over the first 1–2 weeks of treatment.<\/p>\n Very common (>10% of patients):<\/strong><\/p>\n Common (1–10%):<\/strong><\/p>\n \u03a3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b1\u03bb\u03bb\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac:<\/strong><\/p>\n Stop the medication and contact your doctor urgently if you develop severe or persistent headache that does not settle, fainting episodes, a blistering rash, or blue-tinged lips and skin.<\/p>\n Both Angispan-TR and Angiplat are sustained-release oral nitroglycerin capsules. The difference is dose per capsule:<\/p>\n Both products follow the same tolerance rules and the same contraindications — they are clinically interchangeable at equivalent daily doses. Do not combine them on the same day.<\/p>\n Some cardiologists prefer isosorbide mononitrate (ISMN)<\/strong> over oral sustained-release nitroglycerin because ISMN has 100% oral bioavailability (no first-pass metabolism) and more predictable pharmacokinetics. Angispan-TR still has a role when:<\/p>\n MedsBase offers worldwide shipping on every order. Orders are dispatched in discreet packaging and arrive in branded manufacturer packs. Peptides and most cardiovascular generics are stocked in multiple strengths; if your preferred pack size is out of stock, contact customer support for an ETA.<\/p>\n \u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03b5\u03c5\u03b8\u03c5\u03bd\u03ce\u03bd.<\/strong> The information on this page is provided for general education only. It is not a substitute for advice from your own doctor or cardiologist. Nitrates are potent cardiovascular medications with known serious interactions. Talk to a qualified healthcare professional before starting, stopping, or changing therapy, and seek immediate medical attention if chest pain is new, more severe, or lasts longer than 10–15 minutes.<\/p>\n<\/div>\n No. Angispan-TR has an onset of 30–60 minutes — too slow for an acute episode. Use sublingual nitroglycerin or sublingual isosorbide dinitrate (Sorbitrate) 5 mg for rescue.<\/p>\n No — this combination is absolutely contraindicated. PDE5 inhibitors potentiate the blood-pressure drop from nitrates and can be fatal. Allow 24 hours after sildenafil\/vardenafil and 48 hours after tadalafil before any nitrate dose.<\/p>\n Nitrate headache is caused by cerebral vasodilation and is extremely common in the first week. Most patients find it fades on its own after 7–14 days. Paracetamol is safe. Persistent severe headache is a reason to reduce dose or switch to ISMN.<\/p>\n Without a nitrate-free interval, your body develops tolerance within 48–72 hours and the medication stops controlling angina. The overnight break restores drug efficacy the following day.<\/p>\n The entire 6.5 mg is released at once. This causes a large, rapid drop in blood pressure, severe headache, and loss of the prolonged effect. Always swallow the capsule whole.<\/p>\n Yes, this is standard triple anti-anginal therapy. All three classes reduce ischaemia through different mechanisms. Monitor for dizziness and low blood pressure, especially in the first two weeks.<\/p>\n Light alcohol with food is usually tolerated, but alcohol is a vasodilator and can worsen hypotension and dizziness. Avoid heavy drinking.<\/p>\n Yes, provided the nitrate-free interval is respected. Many patients take sustained-release nitroglycerin for years. Annual review with your cardiologist is recommended.<\/p>\n No — abrupt withdrawal of a long-acting nitrate can cause rebound coronary vasospasm and worsening angina. Any taper must be medically supervised.<\/p>\n Take it as soon as you remember, unless your next dose is due within 3 hours — then skip the missed one. Never double up.<\/p>\n Once stable and headache-free, yes. Avoid driving during the first week, after any dose change, or if you feel dizzy.<\/p>\n <\/p>\n \u0386\u03bb\u03bb\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 \u03c3\u03b5 \u03a7\u03c1\u03cc\u03bd\u03b9\u03b5\u03c2 \u03a0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2<\/strong> \u03c0\u03bf\u03c5 \u03bf\u03b9 \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2:<\/p>\n \u2705 Relieves chest pain Angispan-TR contains Nitroglycerin.<\/p>","protected":false},"featured_media":59487,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3260],"product_tag":[4704,4522],"class_list":{"0":"post-59486","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-heart-blood-pressure","9":"product_tag-angispan-tr","10":"product_tag-nitroglycerin","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/59486","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=59486"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/59487"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=59486"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=59486"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=59486"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=59486"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n
What Is Angispan-TR Used For?<\/h2>\n
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How Do Nitrates Work?<\/h2>\n
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Nitrate Tolerance — the Critical Dosing Rule<\/h2>\n
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Angispan-TR Dosing<\/h2>\n
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Who Should Not Take Angispan-TR?<\/h2>\n
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Common Side Effects of Angispan-TR<\/h2>\n
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Angispan-TR vs Angiplat — What is the Difference?<\/h2>\n
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Angispan-TR vs Isosorbide Mononitrate (Monit)<\/h2>\n
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\u03a0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 & \u03a0\u03b1\u03c1\u03ac\u03b4\u03bf\u03c3\u03b7<\/h2>\n
\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n
Can I use Angispan-TR to stop an angina attack?<\/h3>\n
Can I take Angispan-TR with sildenafil, tadalafil or vardenafil?<\/h3>\n
Why do I get headaches on Angispan-TR?<\/h3>\n
Why do I need an 8-hour nitrate-free interval?<\/h3>\n
What happens if I open or chew the capsule?<\/h3>\n
Can I take Angispan-TR with my beta-blocker and calcium channel blocker?<\/h3>\n
Can I drink alcohol while taking Angispan-TR?<\/h3>\n
Is Angispan-TR safe long-term?<\/h3>\n
Can I stop Angispan-TR suddenly if I feel better?<\/h3>\n
What if I miss a dose of Angispan-TR?<\/h3>\n
Can I drive while on Angispan-TR?<\/h3>\n
\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2<\/h3>\n
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\n\u2705 Dilates blood vessels
\n\u2705 Treats angina attacks
\n\u2705 Improves blood flow
\n\u2705 Prevents heart pain<\/p>\n