{"id":59863,"date":"2024-02-28T06:20:59","date_gmt":"2024-02-28T06:20:59","guid":{"rendered":"https:\/\/medsname.com\/olmezest-am\/"},"modified":"2026-05-01T10:49:15","modified_gmt":"2026-05-01T10:49:15","slug":"olmezest-am","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/olmezest-am\/","title":{"rendered":"Olmezest AM"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Olmezest AM?<\/h3>\n<p style=\"margin:0;\"><strong>Olmezest AM<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 <strong>\u0394\u03b9\u03c3\u03ba\u03af\u03bf \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03bf\u03cd \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd \u03c3\u03c7\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 20\/5 mg<\/strong> \u03c4\u03bf\u03c5 <strong>olmesartan 20 mg<\/strong> (\u03ad\u03bd\u03b1\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 angiotensin-II) \u03ba\u03b1\u03b9 <strong>amlodipine 5 mg<\/strong> (a dihydropyridine calcium-channel blocker) from Mankind Pharma. ARB + CCB is one of the <strong>\u03c4\u03c1\u03b5\u03b9\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03b2\u03b1\u03c3\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03c3\u03b5 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b4\u03b5\u03b9\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03cd\u03c2 \u03b4\u03cd\u03bf \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd<\/strong> \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 (\u03bc\u03b1\u03b6\u03af \u03bc\u03b5 ARB+\u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b7 \u03ba\u03b1\u03b9 CCB+\u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b7) \u03ba\u03b1\u03b9 \u03ae\u03c4\u03b1\u03bd \u03bf \u03bd\u03b9\u03ba\u03b7\u03c6\u03cc\u03c1\u03bf\u03c2 \u03ba\u03bb\u03ac\u03b4\u03bf\u03c2 \u03c4\u03b7\u03c2 <strong>\u03b4\u03af\u03ba\u03b7\u03c2 ACCOMPLISH (2008)<\/strong>, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03c0\u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ce\u03bd \u03c3\u03c5\u03bc\u03b2\u03ac\u03bd\u03c4\u03c9\u03bd \u03ba\u03b1\u03c4\u03ac 20% \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf benazepril+HCTZ \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c5\u03c8\u03b7\u03bb\u03cc \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7\u03c2. \u03a4\u03b1 \u03b4\u03cd\u03bf \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd \u03bc\u03ad\u03c3\u03c9 <strong>\u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03ce\u03bd<\/strong>: \u03c4\u03bf olmesartan \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03c4\u03bf\u03bd AT<sub>1<\/sub> \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 (\u03b1\u03b3\u03b3\u03b5\u03b9\u03bf\u03c3\u03c5\u03c3\u03c4\u03bf\u03bb\u03ae, \u03b1\u03bb\u03b4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7, \u03c3\u03c5\u03bc\u03c0\u03b1\u03b8\u03b7\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03ad\u03b3\u03b5\u03c1\u03c3\u03b7)\u00b7 \u03c4\u03bf amlodipine \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03c4\u03bf\u03c5\u03c2 L-\u03c4\u03cd\u03c0\u03bf\u03c5 \u03b1\u03b3\u03c9\u03b3\u03bf\u03cd\u03c2 \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bb\u03b5\u03af\u03bf\u03c5\u03c2 \u03bc\u03c5\u03c2 \u03c4\u03c9\u03bd \u03b1\u03b3\u03b3\u03b5\u03af\u03c9\u03bd (\u03b4\u03b9\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03bf\u03bb\u03af\u03c9\u03bd). \u039c\u03bf\u03bd\u03b1\u03b4\u03b9\u03ba\u03ac \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03c9\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03ce\u03bd, <strong>\u03b7 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 \u03c4\u03bf\u03c5 olmesartan \u03c3\u03c4\u03bf amlodipine \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03bf\u03af\u03b4\u03b7\u03bc\u03b1\u03c4\u03c9\u03bd \u03b1\u03c3\u03c4\u03c1\u03b1\u03b3\u03ac\u03bb\u03c9\u03bd \u03b1\u03c0\u03cc \u03c4\u03bf amlodipine \u03ba\u03b1\u03c4\u03ac \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 50%<\/strong> \u2014 \u03b7 \u03c6\u03bb\u03b5\u03b2\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 ARB \u03b9\u03c3\u03bf\u03c1\u03c1\u03bf\u03c0\u03b5\u03af \u03c4\u03b7 \u03b4\u03b9\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03c9\u03bd \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03bf\u03bb\u03af\u03c9\u03bd \u03b1\u03c0\u03cc \u03c4\u03bf amlodipine, \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03c5\u03b4\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ae \u03c0\u03af\u03b5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c4\u03c1\u03b9\u03c7\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd \u03b1\u03b3\u03b3\u03b5\u03af\u03c9\u03bd. \u03a4\u03c5\u03c0\u03b9\u03ba\u03ae \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1: \u03ad\u03bd\u03b1 \u03b4\u03b9\u03c3\u03ba\u03af\u03bf \u03bc\u03b9\u03b1 \u03c6\u03bf\u03c1\u03ac \u03c4\u03b7\u03bd \u03b7\u03bc\u03ad\u03c1\u03b1. <strong>\u0391\u03c0\u03bf\u03bb\u03cd\u03c4\u03c9\u03c2 \u03b1\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03af\u03ba\u03bd\u03c5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7<\/strong> (olmesartan), \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c4\u03b1\u03c3\u03af\u03b1, \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03b1\u03bf\u03c1\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03ad\u03bd\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c6\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03bc\u03c5\u03bf\u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1. \u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03ae\u03c3\u03c4\u03b5 \u03c4\u03bf \u03ba\u03ac\u03bb\u03b9\u03bf, \u03c4\u03b7\u03bd \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03bf\u03af\u03b4\u03b7\u03bc\u03b1 \u03c4\u03c9\u03bd \u03b1\u03c3\u03c4\u03c1\u03b1\u03b3\u03ac\u03bb\u03c9\u03bd.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong> \u03a0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2 WHO-GMP \u00b7 \u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u00b7 \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u00b7 1,400+ \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 <a href=\"https:\/\/medsbase.com\/el\/reviews\/\">\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\"><strong>\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n<h3>\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n<p>\u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n<h2 class=\"wp-block-heading\">What Is Olmezest AM?<\/h2>\n<p>Olmezest AM is an oral fixed-dose combination tablet supplying <strong>olmesartan 20 mg<\/strong> (olmesartan medoxomil) \u03ba\u03b1\u03b9 <strong>amlodipine 5 mg<\/strong> (amlodipine besilate) in a single pill. Made by Mankind Pharma, supplied in 30-180 tablets.<\/p>\n<p>\u03a4\u03bf Olmesartan \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 angiotensin-II (ARB) \u03c0\u03bf\u03c5 \u03b5\u03b9\u03c3\u03ae\u03c7\u03b8\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7 Daiichi-Sankyo \u03c4\u03bf 2002 \u03c9\u03c2 Benicar\/Olmetec. \u0388\u03c7\u03b5\u03b9 \u03b7\u03bc\u03b9\u03b6\u03c9\u03ae 13 \u03c9\u03c1\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03c0\u03b9\u03bf \u03b9\u03c3\u03c7\u03c5\u03c1\u03bf\u03cd\u03c2 ARB \u03b1\u03bd\u03ac \u03c7\u03b9\u03bb\u03b9\u03bf\u03c3\u03c4\u03cc\u03b3\u03c1\u03b1\u03bc\u03bc\u03bf. \u03a4\u03bf Amlodipine \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03bc\u03b1\u03ba\u03c1\u03ac\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1\u03c2 \u03b4\u03b9\u03b1\u03cb\u03b4\u03c1\u03bf\u03c0\u03c5\u03c1\u03b9\u03b4\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03bd\u03b1\u03bb\u03b9\u03ce\u03bd \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5, \u03c0\u03bf\u03c5 \u03b5\u03b9\u03c3\u03ae\u03c7\u03b8\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7 Pfizer \u03c4\u03bf 1990 \u03c9\u03c2 Norvasc. \u039c\u03b5 \u03b7\u03bc\u03b9\u03b6\u03c9\u03ae 30-50 \u03c9\u03c1\u03ce\u03bd, \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03b5\u03b9 \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03bf\u03bc\u03b1\u03bb\u03ae \u03ba\u03ac\u03bb\u03c5\u03c8\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2 \u03b3\u03b9\u03b1 24 \u03ce\u03c1\u03b5\u03c2.<\/p>\n<h2 class=\"wp-block-heading\">\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03c3\u03b5\u03c4\u03b5 \u03ad\u03bd\u03b1\u03bd ARB \u03bc\u03b5 \u03ad\u03bd\u03b1\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 \u03ba\u03b1\u03bd\u03b1\u03bb\u03b9\u03ce\u03bd \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5;<\/h2>\n<p>\u039f \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 ARB + \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 \u03b4\u03b9\u03b1\u03cb\u03b4\u03c1\u03bf\u03c0\u03c5\u03c1\u03b9\u03b4\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03bd\u03b1\u03bb\u03b9\u03ce\u03bd \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5 (CCB) \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03b4\u03cd\u03bf \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03b5\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7. \u0397 \u03bb\u03bf\u03b3\u03b9\u03ba\u03ae:<\/p>\n<ul>\n<li><strong>\u03a3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03af \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af.<\/strong> \u03a4\u03bf Olmesartan \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03c4\u03ad\u03bd\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03b3\u03b3\u03b5\u03af\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf angiotensin-II \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03c1\u03cc\u03bb\u03bf \u03c4\u03b7\u03c2 \u03b1\u03bb\u03b4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2, \u03b5\u03bd\u03ce \u03c4\u03bf Amlodipine \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03c5\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03c9\u03bd \u03bb\u03b5\u03af\u03c9\u03bd \u03bc\u03c5\u03ce\u03bd \u03c4\u03c9\u03bd \u03b1\u03b3\u03b3\u03b5\u03af\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b1\u03c3\u03b2\u03ad\u03c3\u03c4\u03b9\u03bf. \u039c\u03b1\u03b6\u03af \u03c0\u03b1\u03c1\u03ad\u03c7\u03bf\u03c5\u03bd \u03bc\u03b9\u03b1 \u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c4\u03ac 10-15 mmHg \u03c3\u03c5\u03c3\u03c4\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b4\u03cd\u03bf.<\/li>\n<li><strong>\u039c\u03b7 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7.<\/strong> \u03a3\u03b5 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03cd\u03c2 \u03c0\u03bf\u03c5 \u03b2\u03b1\u03c3\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b5\u03c2, \u03bf \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 ARB+CCB <strong>\u03b4\u03b5\u03bd \u03b5\u03c0\u03b9\u03b4\u03b5\u03b9\u03bd\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c7\u03ae \u03c3\u03c4\u03b7 \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7, \u03c4\u03bf \u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03ae \u03c4\u03b1 \u03bf\u03c5\u03c1\u03b9\u03ba\u03ac \u03bf\u03be\u03ad\u03b1<\/strong>. \u0391\u03c5\u03c4\u03cc \u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03c4\u03bf\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03bf \u03b3\u03b9\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03cc \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf, \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03ae \u03bf\u03c5\u03c1\u03b9\u03ba\u03ae \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1.<\/li>\n<li><strong>\u0391\u03bd\u03c4\u03b9\u03c1\u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bf\u03af\u03b4\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03c4\u03bf\u03bd \u03b1\u03c3\u03c4\u03c1\u03ac\u03b3\u03b1\u03bb\u03bf \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b1\u03bc\u03bb\u03bf\u03b4\u03b9\u03c0\u03af\u03bd\u03b7.<\/strong> \u0397 \u03b1\u03bc\u03bb\u03bf\u03b4\u03b9\u03c0\u03af\u03bd\u03b7 \u03b4\u03b9\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03c0\u03c1\u03bf\u03c4\u03b9\u03bc\u03b7\u03c3\u03b9\u03b1\u03ba\u03ac \u03c4\u03b9\u03c2 \u03c0\u03c1\u03bf\u03c4\u03c1\u03b9\u03c7\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03c1\u03c4\u03b7\u03c1\u03af\u03b5\u03c2, \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03c5\u03b4\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ae \u03c0\u03af\u03b5\u03c3\u03b7 \u03c3\u03c4\u03b1 \u03c4\u03c1\u03b9\u03c7\u03bf\u03b5\u03b9\u03b4\u03ae \u03ba\u03b1\u03b9 \u03c9\u03b8\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c5\u03b3\u03c1\u03cc \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b9\u03c3\u03c4\u03bf\u03cd\u03c2 \u2014 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03bf\u03c1\u03b1\u03c4\u03cc \u03c9\u03c2 \u03bf\u03af\u03b4\u03b7\u03bc\u03b1 \u03c3\u03c4\u03bf\u03bd \u03b1\u03c3\u03c4\u03c1\u03ac\u03b3\u03b1\u03bb\u03bf \u03c3\u03b5 10-20% \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd. \u039f\u03b9 ARB \u03b5\u03be\u03b9\u03c3\u03bf\u03c1\u03c1\u03bf\u03c0\u03bf\u03cd\u03bd \u03b1\u03c5\u03c4\u03cc \u03b4\u03b9\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03b9\u03c7\u03bf\u03b5\u03b9\u03b4\u03ad\u03c2 \u03c6\u03bb\u03b5\u03b2\u03b9\u03ba\u03cc \u03b4\u03af\u03ba\u03c4\u03c5\u03bf, \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03c5\u03b4\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ae \u03c0\u03af\u03b5\u03c3\u03b7 \u03c3\u03c4\u03b1 \u03c4\u03c1\u03b9\u03c7\u03bf\u03b5\u03b9\u03b4\u03ae. <strong>\u0397 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 \u03b5\u03bd\u03cc\u03c2 ARB \u03c3\u03c4\u03b7\u03bd \u03b1\u03bc\u03bb\u03bf\u03b4\u03b9\u03c0\u03af\u03bd\u03b7 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03ba\u03b1\u03c4\u03ac \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c4\u03bf \u03bc\u03b9\u03c3\u03cc \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03c4\u03bf\u03c5 \u03bf\u03af\u03b4\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03c4\u03bf\u03bd \u03b1\u03c3\u03c4\u03c1\u03ac\u03b3\u03b1\u03bb\u03bf.<\/strong> \u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03b9\u03c3\u03c7\u03c5\u03c1\u03cc\u03c4\u03b5\u03c1\u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03b5\u03c0\u03b9\u03c7\u03b5\u03af\u03c1\u03b7\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc ARB+CCB \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03b7\u03c2 \u03c7\u03c1\u03ae\u03c3\u03b7\u03c2 \u03bf\u03c0\u03bf\u03b9\u03bf\u03c5\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf\u03c5.<\/li>\n<li><strong>\u0391\u03bd\u03c4\u03b9\u03c1\u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 RAAS.<\/strong> \u0397 \u03b1\u03bc\u03bb\u03bf\u03b4\u03b9\u03c0\u03b9\u03bd\u03bf\u03c0\u03b1\u03b3\u03ae\u03c2 \u03b4\u03b9\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03c9\u03bd \u03b1\u03b3\u03b3\u03b5\u03af\u03c9\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03b1\u03bd\u03c4\u03b1\u03bd\u03b1\u03ba\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03c1\u03b5\u03bd\u03af\u03bd\u03b7\u03c2-\u03b1\u03b3\u03b3\u03b5\u03b9\u03bf\u03c4\u03b5\u03bd\u03c3\u03af\u03bd\u03b7\u03c2\u00b7 \u03bf ARB \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03b9 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03b1\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7, \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03b5\u03c1\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bc\u03bb\u03bf\u03b4\u03b9\u03c0\u03af\u03bd\u03b7\u03c2 \u03c3\u03c4\u03b7\u03bd \u03c0\u03af\u03b5\u03c3\u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c4\u03b7 \u03c3\u03c5\u03bc\u03c0\u03b1\u03b8\u03b7\u03c4\u03b9\u03ba\u03ae \u03c4\u03b1\u03c7\u03c5\u03ba\u03b1\u03c1\u03b4\u03af\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b2\u03c1\u03b1\u03c7\u03cd\u03b2\u03b9\u03b5\u03c2 CCB.<\/li>\n<\/ul>\n<p><strong>\u0392\u03ac\u03c3\u03b7 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03c4\u03b9\u03ba\u03ce\u03bd \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03c9\u03bd:<\/strong><\/p>\n<ul>\n<li><strong>\u03b4\u03af\u03ba\u03b7\u03c2 ACCOMPLISH (2008)<\/strong> \u2014 \u03bf \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03bc\u03c0\u03b5\u03bd\u03b1\u03b6\u03b5\u03c0\u03c1\u03af\u03bb\u03b7\u03c2+\u03b1\u03bc\u03bb\u03bf\u03b4\u03b9\u03c0\u03af\u03bd\u03b7\u03c2 \u03bc\u03b5\u03af\u03c9\u03c3\u03b5 \u03c4\u03b9\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ad\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03c4\u03ac 20% \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03b7\u03c2 \u03bc\u03c0\u03b5\u03bd\u03b1\u03b6\u03b5\u03c0\u03c1\u03af\u03bb\u03b7\u03c2+HCTZ \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7\u03c2. \u0395\u03c0\u03b5\u03ba\u03c4\u03ac\u03b8\u03b7\u03ba\u03b5 \u03b5\u03c5\u03c1\u03ad\u03c9\u03c2 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03cd\u03c2 ARB+\u03b1\u03bc\u03bb\u03bf\u03b4\u03b9\u03c0\u03af\u03bd\u03b7\u03c2.<\/li>\n<li><strong>ASCOT-BPLA (2005)<\/strong> \u2014 \u03c4\u03bf \u03c3\u03c7\u03ae\u03bc\u03b1 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b7\u03bd \u03b1\u03bc\u03bb\u03bf\u03b4\u03b9\u03c0\u03af\u03bd\u03b7 (\u03c3\u03c5\u03c7\u03bd\u03ac \u03bc\u03b5 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 \u03c0\u03b5\u03c1\u03b9\u03bd\u03b4\u03bf\u03c0\u03c1\u03af\u03bb\u03b7\u03c2) \u03c5\u03c0\u03b5\u03c1\u03ad\u03b2\u03b7 \u03c4\u03bf \u03c3\u03c7\u03ae\u03bc\u03b1 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b7\u03bd \u03b1\u03c4\u03b5\u03bd\u03bf\u03bb\u03cc\u03bb\u03b7 \u03c3\u03b5 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03ac \u03b5\u03c0\u03b5\u03b9\u03c3\u03cc\u03b4\u03b9\u03b1.<\/li>\n<li><strong>\u0394\u03bf\u03ba\u03b9\u03bc\u03ae COACH (2010)<\/strong> \u2014 \u03bf\u03b9 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03bf\u03b4\u03bf\u03c3\u03b9\u03ba\u03bf\u03af \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03af \u03bf\u03bb\u03bc\u03b5\u03c3\u03b1\u03c1\u03c4\u03ac\u03bd\u03b7\u03c2\/\u03b1\u03bc\u03bb\u03bf\u03b4\u03b9\u03c0\u03af\u03bd\u03b7\u03c2 \u03ad\u03c6\u03c4\u03b1\u03c3\u03b1\u03bd \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c5\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2 \u03c3\u03b5 60-70% \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 35-50% \u03c3\u03c4\u03b7 \u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1.<\/li>\n<li><strong>\u039c\u03b5\u03c4\u03b1-\u03b1\u03bd\u03b1\u03bb\u03cd\u03c3\u03b5\u03b9\u03c2<\/strong> \u03c3\u03c5\u03bd\u03b5\u03c7\u03ce\u03c2 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03bf \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 ARB+CCB \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03b9 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ad\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b1\u03bd\u03ac mmHg \u03bc\u03b5\u03af\u03c9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc ARB+\u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b9\u03bf.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u0394\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 &amp; \u03a4\u03b9\u03c4\u03bb\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7<\/h2>\n<p><strong>\u03a4\u03c5\u03c0\u03b9\u03ba\u03ae \u03b4\u03cc\u03c3\u03b7:<\/strong> \u03ad\u03bd\u03b1 \u03b4\u03b9\u03c3\u03ba\u03af\u03bf 20\/5 mg \u03bc\u03b9\u03b1 \u03c6\u03bf\u03c1\u03ac \u03c4\u03b7\u03bd \u03b7\u03bc\u03ad\u03c1\u03b1. \u0397 \u03ce\u03c1\u03b1 \u03c4\u03b7\u03c2 \u03b7\u03bc\u03ad\u03c1\u03b1\u03c2 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1\u00b7 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03ce\u03c1\u03b1 \u03ba\u03ac\u03b8\u03b5 \u03b7\u03bc\u03ad\u03c1\u03b1.<\/p>\n<p><strong>When to start Olmezest AM:<\/strong><\/p>\n<ul>\n<li>\u0397 \u03c0\u03af\u03b5\u03c3\u03b7 \u03b4\u03b5\u03bd \u03b5\u03bb\u03ad\u03b3\u03c7\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 <a href=\"https:\/\/medsbase.com\/el\/olmesar\/\">\u03bf\u03bb\u03bc\u03b5\u03c3\u03b1\u03c1\u03c4\u03ac\u03bd\u03b7<\/a> \u03ae <a href=\"https:\/\/medsbase.com\/el\/amlode\/\">amlodipine<\/a> \u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c3\u03b5 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b4\u03cc\u03c3\u03b7 \u03b3\u03b9\u03b1 4-6 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2<\/li>\n<li>\u03a3\u03c4\u03ac\u03b4\u03b9\u03bf 2 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7\u03c2 (\u2265160\/100) \u03c9\u03c2 \u03b1\u03c1\u03c7\u03b9\u03ba\u03cc\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03b4\u03cd\u03bf \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03c0\u03c1\u03bf\u03c4\u03b9\u03bc\u03ae\u03c3\u03b5\u03b9\u03c2 AHA\/ACC<\/li>\n<li>\u0391\u03cd\u03be\u03b7\u03c3\u03b7 \u03b4\u03cc\u03c3\u03b7\u03c2 \u03cc\u03c4\u03b1\u03bd \u03b7 \u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03b1\u03bc\u03bb\u03bf\u03b4\u03b9\u03c0\u03af\u03bd\u03b7 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03b1\u03bd\u03b5\u03ba\u03c4\u03ae \u03bf\u03af\u03b4\u03b7\u03bc\u03b1 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03c4\u03c1\u03b1\u03b3\u03ac\u03bb\u03bf\u03c5\u03c2 \u2014 \u03b7 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 ARB \u03c3\u03c5\u03c7\u03bd\u03ac \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03bf \u03bf\u03af\u03b4\u03b7\u03bc\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf \u03ae\u03bc\u03b9\u03c3\u03c5 \u03b5\u03bd\u03ce \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03af\u03b5\u03c3\u03b7<\/li>\n<li>\u0391\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03cc \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf, \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03ae \u03bf\u03c5\u03c1\u03b9\u03ba\u03ae \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1 \u03cc\u03c0\u03bf\u03c5 \u03bf \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 ARB+CCB \u03c0\u03c1\u03bf\u03c4\u03b9\u03bc\u03ac\u03c4\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ac \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03bf\u03c5 ARB+\u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b7\u03c2<\/li>\n<\/ul>\n<p><strong>\u03a0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03b4\u03cc\u03c3\u03b7\u03c2:<\/strong> most manufacturers supply 20\/5, 40\/5, 20\/10, and 40\/10 mg strengths. Start at 20\/5; increase to 40\/5 if BP responds well but target not reached; increase to 40\/10 for maximum single-pill effect. Beyond 40\/10, add a third class &mdash; typically a thiazide (Olmezest AM + HCTZ = ARB+CCB+thiazide triple).<\/p>\n<p><strong>\u03a0\u03c1\u03cc\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2:<\/strong><\/p>\n<ul>\n<li><strong>\u0392\u03b1\u03c3\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7:<\/strong> \u03bf\u03c5\u03c1\u03af\u03b1, \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03bb\u03cd\u03c4\u03b5\u03c2, \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7, eGFR. \u0391\u03c1\u03c7\u03b9\u03ba\u03ae \u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf \u03c3\u03c0\u03af\u03c4\u03b9.<\/li>\n<li><strong>1-2 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2:<\/strong> \u03b5\u03c0\u03b1\u03bd\u03ac\u03bb\u03b7\u03c8\u03b7 U&amp;E. \u0391\u03bd\u03b1\u03bc\u03ad\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b9\u03ba\u03c1\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7\u03c2 (\u03ad\u03c9\u03c2 30% \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bf\u03b4\u03b5\u03ba\u03c4\u03ae). \u0397 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03bb\u03af\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03b7.<\/li>\n<li><strong>4-6 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2:<\/strong> \u03b5\u03c0\u03b1\u03bd\u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2\u00b7 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03bf\u03af\u03b4\u03b7\u03bc\u03b1 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03c4\u03c1\u03b1\u03b3\u03ac\u03bb\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03c5\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03af\u03b1 \u03bf\u03cd\u03bb\u03c9\u03bd.<\/li>\n<li><strong>\u03a3\u03c5\u03bd\u03b5\u03c7\u03ae\u03c2 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7:<\/strong> \u03b5\u03c4\u03ae\u03c3\u03b9\u03b1 U&amp;E. \u039c\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf \u03c3\u03c0\u03af\u03c4\u03b9 \u03b4\u03cd\u03bf \u03c6\u03bf\u03c1\u03ad\u03c2 \u03c4\u03b7\u03bd \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1.<\/li>\n<li><strong>\u0394\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7:<\/strong> \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7\u03c2 &gt;30%, \u03ba\u03ac\u03bb\u03b9\u03bf &gt;5.5, \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c4\u03b1\u03c3\u03af\u03b1, \u03c3\u03bf\u03b2\u03b1\u03c1\u03cc \u03bf\u03af\u03b4\u03b7\u03bc\u03b1 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03c4\u03c1\u03b1\u03b3\u03ac\u03bb\u03bf\u03c5\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03b1\u03bd\u03c4\u03b1\u03c0\u03bf\u03ba\u03c1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03b4\u03cc\u03c3\u03b7\u03c2, \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b1\u03b4\u03b9\u03b5\u03c5\u03ba\u03c1\u03af\u03bd\u03b9\u03c3\u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03c1\u03bf\u03b9\u03b1 \u03ae \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 (\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03b5\u03b9\u03b4\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03b5\u03bd\u03c4\u03b5\u03c1\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1 \u03c4\u03cd\u03c0\u03bf\u03c5 \u03c3\u03c0\u03c1\u03bf\u03cd \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03bf\u03bb\u03bc\u03b5\u03c3\u03b1\u03c1\u03c4\u03ac\u03bd\u03b7).<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/h2>\n<p><strong>\u03a3\u03c5\u03c7\u03bd\u03ac (&gt;1%):<\/strong><\/p>\n<ul>\n<li><strong>\u039f\u03af\u03b4\u03b7\u03bc\u03b1 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03c4\u03c1\u03b1\u03b3\u03ac\u03bb\u03bf\u03c5\u03c2<\/strong> &mdash; amlodipine-related; typically milder on Olmezest AM than on amlodipine monotherapy (roughly halved by the ARB component)<\/li>\n<li>\u0389\u03c0\u03b9\u03b1 \u03b6\u03ac\u03bb\u03b7, \u03b5\u03c1\u03c5\u03b8\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1, \u03c0\u03bf\u03bd\u03bf\u03ba\u03ad\u03c6\u03b1\u03bb\u03bf\u03c2 (\u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c4\u03b9\u03c2 \u03c0\u03c1\u03ce\u03c4\u03b5\u03c2 1-2 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2\u00b7 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03c3\u03c3\u03b5\u03c4\u03b1\u03b9 \u03b1\u03bd\u03bf\u03c7\u03ae \u03c3\u03c4\u03b1 \u03b1\u03b3\u03b3\u03b5\u03b9\u03bf\u03b4\u03b9\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ac)<\/li>\n<li>\u03a0\u03b1\u03bb\u03bc\u03bf\u03af (\u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03bc\u03bb\u03bf\u03b4\u03b9\u03c0\u03af\u03bd\u03b7\u00b7 \u03b7 \u03b1\u03bd\u03c4\u03b1\u03bd\u03b1\u03ba\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03c4\u03b1\u03c7\u03c5\u03ba\u03b1\u03c1\u03b4\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ae\u03c0\u03b9\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03bc\u03b1\u03ba\u03c1\u03ac\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03b1\u03bc\u03bb\u03bf\u03b4\u03b9\u03c0\u03af\u03bd\u03b7)<\/li>\n<li>\u0391\u03bd\u03b1\u03bc\u03b5\u03bd\u03cc\u03bc\u03b5\u03bd\u03b7 \u03bc\u03b9\u03ba\u03c1\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7\u03c2 (\u03ad\u03c9\u03c2 30%)<\/li>\n<li>\u0389\u03c0\u03b9\u03b1 \u03c5\u03c0\u03b5\u03c1\u03ba\u03b1\u03bb\u03b9\u03b1\u03b9\u03bc\u03af\u03b1<\/li>\n<li>\u039a\u03bf\u03cd\u03c1\u03b1\u03c3\u03b7, \u03bd\u03b1\u03c5\u03c4\u03af\u03b1, \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b1\u03bd\u03ce\u03c4\u03b5\u03c1\u03c9\u03bd \u03b1\u03bd\u03b1\u03c0\u03bd\u03b5\u03c5\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03bf\u03b4\u03ce\u03bd<\/li>\n<\/ul>\n<p><strong>\u03a3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b1\u03bb\u03bb\u03ac \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac:<\/strong><\/p>\n<ul>\n<li><strong>\u03a5\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03af\u03b1 \u03bf\u03cd\u03bb\u03c9\u03bd<\/strong> \u2014 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03bc\u03bb\u03bf\u03b4\u03b9\u03c0\u03af\u03bd\u03b7; 1-3% \u03c4\u03c9\u03bd \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c7\u03c1\u03b7\u03c3\u03c4\u03ce\u03bd. \u03a0\u03c1\u03bf\u03c3\u03bf\u03c7\u03ae \u03c3\u03c4\u03b7\u03bd \u03c3\u03c4\u03bf\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c5\u03b3\u03b9\u03b5\u03b9\u03bd\u03ae \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf. \u0391\u03bb\u03bb\u03b1\u03b3\u03ae \u03c3\u03b5 \u03bc\u03b7-DHP \u03ae \u03bc\u03cc\u03bd\u03bf ARB \u03ba\u03b1\u03b8\u03b5\u03c3\u03c4\u03ce\u03c2 \u03b5\u03ac\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03bf\u03b2\u03b1\u03c1\u03cc.<\/li>\n<li><strong>\u0391\u03b3\u03b3\u03b5\u03b9\u03bf\u03bf\u03af\u03b4\u03b7\u03bc\u03b1<\/strong> \u2014 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf\u03c2 \u03c1\u03c5\u03b8\u03bc\u03cc\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 ACE \u03b1\u03bb\u03bb\u03ac \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c2. \u0394\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03b1\u03bc\u03ad\u03c3\u03c9\u03c2.<\/li>\n<li><strong>\u03a3\u03bf\u03b2\u03b1\u03c1\u03ae \u03c5\u03c0\u03b5\u03c1\u03ba\u03b1\u03bb\u03b9\u03b1\u03b9\u03bc\u03af\u03b1<\/strong> \u2014 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03bc\u03b5 \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03bb\u03af\u03bf\u03c5, K+-\u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac, NSAIDs \u03ae CKD<\/li>\n<li><strong>\u039f\u03be\u03b5\u03af\u03b1 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b2\u03bb\u03ac\u03b2\u03b7 \u03c3\u03b5 \u03b4\u03b9\u03c0\u03bb\u03ae \u03c3\u03c4\u03b5\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c1\u03c4\u03b7\u03c1\u03af\u03b1\u03c2<\/strong> \u2014 \u03af\u03b4\u03b9\u03bf\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03bc\u03b5 \u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 ARBs<\/li>\n<li><strong>\u0395\u03b9\u03b4\u03b9\u03ba\u03ae \u03b3\u03b9\u03b1 \u03bf\u03bb\u03bc\u03b5\u03c3\u03b1\u03c1\u03c4\u03ac\u03bd\u03b7 \u03c3\u03c0\u03c1\u03bf\u03c5\u03b5\u03b9\u03b4\u03ae\u03c2 \u03b5\u03bd\u03c4\u03b5\u03c1\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1<\/strong> (FDA 2013 \u03c0\u03c1\u03bf\u03b5\u03b9\u03b4\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7) \u2014 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b4\u03b9\u03ac\u03c1\u03c1\u03bf\u03b9\u03b1, \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2, \u03b1\u03c4\u03c1\u03bf\u03c6\u03af\u03b1 \u03b2\u03bb\u03b5\u03bd\u03bd\u03bf\u03b3\u03cc\u03bd\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03bc\u03b9\u03bc\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03bf\u03b9\u03bb\u03b9\u03bf\u03ba\u03ac\u03ba\u03b7. \u03a3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b1\u03bb\u03bb\u03ac \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7\u00b7 \u03b5\u03c0\u03b9\u03bb\u03cd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03c4\u03b7\u03c2 \u03bf\u03bb\u03bc\u03b5\u03c3\u03b1\u03c1\u03c4\u03ac\u03bd\u03b7\u03c2.<\/li>\n<li><strong>\u0395\u03be\u03ac\u03c1\u03b8\u03c1\u03c9\u03c3\u03b7 \u03ae \u03b5\u03c0\u03b9\u03b4\u03b5\u03af\u03bd\u03c9\u03c3\u03b7 \u039a\u03a3 \u03c3\u03b5 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ac \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf \u039a\u03a3<\/strong> \u2014 \u03b7 \u03b1\u03bc\u03bb\u03bf\u03b4\u03b9\u03c0\u03af\u03bd\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03c5\u03b4\u03ad\u03c4\u03b5\u03c1\u03b7 \u03c3\u03b5 \u039a\u03a3-REF (\u03b4\u03bf\u03ba\u03b9\u03bc\u03ae PRAISE) \u03b1\u03bb\u03bb\u03ac \u03cc\u03c7\u03b9 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u00b7 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2 \u03b3\u03b9\u03b1 \u039a\u03a3-REF.<\/li>\n<li><strong>\u03a5\u03c0\u03bf\u03c4\u03bf\u03bd\u03af\u03b1 \u03c0\u03c1\u03ce\u03c4\u03b7\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2<\/strong> \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c5\u03c0\u03bf\u03c4\u03cc\u03bd\u03b9\u03b1 \u03ae \u03c3\u03b5 \u03c5\u03c8\u03b7\u03bb\u03ad\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u0391\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li><strong>\u0395\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7 \u2014 \u0391\u03a0\u039f\u039b\u03a5\u03a4\u0397 \u03b1\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03af\u03ba\u03bd\u03c5\u03c3\u03b7 \u03c3\u03b5 \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03c4\u03c1\u03af\u03bc\u03b7\u03bd\u03b1.<\/strong> \u03a4\u03bf olmesartan \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b5\u03c1\u03b1\u03c4\u03bf\u03b3\u03cc\u03bd\u03bf (\u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b1\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03b5\u03bc\u03b2\u03c1\u03cd\u03bf\u03c5, \u03bf\u03bb\u03b9\u03b3\u03bf\u03c5\u03b4\u03c1\u03af\u03b1, \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c0\u03bb\u03b1\u03c3\u03af\u03b1). \u0391\u03bb\u03bb\u03b1\u03b3\u03ae \u03c3\u03b5 <a href=\"https:\/\/medsbase.com\/el\/labebet\/\">\u03bb\u03b1\u03b2\u03b5\u03c4\u03b1\u03bb\u03cc\u03bb\u03b7<\/a>, \u03bc\u03b5\u03b8\u03c5ldopa \u03ae \u03bd\u03b9\u03c6\u03b5\u03b4\u03af\u03bd\u03b7 \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7 \u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7.<\/li>\n<li><strong>\u03a3\u03bf\u03b2\u03b1\u03c1\u03ae \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c5\u03c0\u03cc\u03c4\u03b1\u03c3\u03b7<\/strong> (\u03c3\u03c5\u03c3\u03c4\u03bf\u03bb\u03b9\u03ba\u03ae \u03c0\u03af\u03b5\u03c3\u03b7 &lt;90)<\/li>\n<li><strong>\u03a3\u03bf\u03b2\u03b1\u03c1\u03ae \u03c3\u03c4\u03ad\u03bd\u03c9\u03c3\u03b7 \u03b1\u03bf\u03c1\u03c4\u03ae\u03c2<\/strong> \u2014 \u03b7 \u03b1\u03bc\u03bf\u03c1\u03c4\u03b9\u03c0\u03af\u03bd\u03b7\u03c2-\u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03b1\u03b3\u03b3\u03b5\u03b9\u03bf\u03b4\u03b9\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03b5\u03b9 \u03bb\u03b9\u03c0\u03bf\u03b8\u03c5\u03bc\u03af\u03b1 \u03c3\u03b5 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae \u03b1\u03c0\u03cc\u03c6\u03c1\u03b1\u03be\u03b7<\/li>\n<li><strong>\u03a5\u03c0\u03b5\u03c1\u03c4\u03c1\u03bf\u03c6\u03b9\u03ba\u03ae \u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03bc\u03c5\u03bf\u03c0\u03ac\u03c4\u03b9\u03b1 \u03bc\u03b5 \u03b1\u03c0\u03cc\u03c6\u03c1\u03b1\u03be\u03b7<\/strong> \u2014 \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b1 \u03b1\u03bd\u03b7\u03c3\u03c5\u03c7\u03af\u03b1 \u03b3\u03b9\u03b1 \u03b4\u03c5\u03bd\u03b1\u03bc\u03b9\u03ba\u03ae \u03b1\u03c0\u03cc\u03c6\u03c1\u03b1\u03be\u03b7<\/li>\n<li><strong>\u039a\u03b1\u03c1\u03b4\u03b9\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03c3\u03bf\u03ba \u03ae \u03bf\u03be\u03cd \u03ad\u03bc\u03c6\u03c1\u03b1\u03b3\u03bc\u03b1 \u03b5\u03bd\u03c4\u03cc\u03c2 1 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1\u03c2<\/strong><\/li>\n<li><strong>\u03a3\u03c4\u03b5\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b1\u03bc\u03c6\u03cc\u03c4\u03b5\u03c1\u03c9\u03bd \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ce\u03bd \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03ce\u03bd<\/strong><\/li>\n<li><strong>\u0399\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03b1\u03b3\u03b3\u03b5\u03b9\u03bf\u03bf\u03af\u03b4\u03b7\u03bc\u03b1 \u03b1\u03c0\u03cc ARB \u03ae \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 ACE<\/strong> (\u03b5\u03bd\u03c4\u03cc\u03c2 4 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03c9\u03bd)<\/li>\n<li><strong>\u03a5\u03c0\u03b5\u03c1\u03ba\u03b1\u03bb\u03b9\u03b1\u03b9\u03bc\u03af\u03b1 &gt;5,5 mmol\/L \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7<\/strong><\/li>\n<li><strong>\u03a3\u03bf\u03b2\u03b1\u03c1\u03ae \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 (Child-Pugh C)<\/strong><\/li>\n<li><strong>\u03a4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 sacubitril\/valsartan (Entresto)<\/strong>, <strong>\u03b1\u03bb\u03b9\u03c3\u03ba\u03b9\u03c1\u03ad\u03bd \u03c3\u03b5 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03ae \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf<\/strong>, <strong>\u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 ACE<\/strong> (\u03b2\u03bb\u03ac\u03b2\u03b7 ONTARGET)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03a6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd<\/h2>\n<ul>\n<li><strong>\u03a3\u03b9\u03bc\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7<\/strong> \u2014 \u03b7 \u03b1\u03bc\u03bf\u03c1\u03c4\u03b9\u03c0\u03af\u03bd\u03b7 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ad\u03ba\u03b8\u03b5\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03c3\u03b9\u03bc\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03c1\u03b1\u03b2\u03b4\u03bf\u03bc\u03c5\u03cc\u03bb\u03c5\u03c3\u03b7\u03c2. <strong>\u0397 \u03b4\u03cc\u03c3\u03b7 \u03c3\u03b9\u03bc\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7\u03c2 \u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c5\u03c0\u03b5\u03c1\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03c4\u03b1 20 mg \u03b7\u03bc\u03b5\u03c1\u03b7\u03c3\u03af\u03c9\u03c2<\/strong> \u03cc\u03c4\u03b1\u03bd \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03bc\u03bf\u03c1\u03c4\u03b9\u03c0\u03af\u03bd\u03b7. \u03a7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03c4\u03b5 \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 (\u03c1\u03bf\u03c5\u03c3\u03bf\u03c5\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7, \u03b1\u03c4\u03bf\u03c1\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 \u03ad\u03c9\u03c2 40 mg) \u03b5\u03ac\u03bd \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7\u03c2.<\/li>\n<li><strong>\u0399\u03c3\u03c7\u03c5\u03c1\u03bf\u03af \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 CYP3A4<\/strong> (\u03ba\u03bb\u03b1\u03c1\u03b9\u03b8\u03c1\u03bf\u03bc\u03c5\u03ba\u03af\u03bd\u03b7, \u03b9\u03c4\u03c1\u03b1\u03ba\u03bf\u03bd\u03b1\u03b6\u03cc\u03bb\u03b7, \u03ba\u03b5\u03c4\u03bf\u03ba\u03bf\u03bd\u03b1\u03b6\u03cc\u03bb\u03b7, \u03c1\u03b9\u03c4\u03bf\u03bd\u03b1\u03b2\u03af\u03c1, \u03ba\u03bf\u03bc\u03c0\u03b9\u03ba\u03b9\u03c3\u03c4\u03ac\u03c4, \u03b4\u03b9\u03bb\u03c4\u03b9\u03b1\u03b6\u03ad\u03bc\u03b7, \u03b2\u03b5\u03c1\u03b1\u03c0\u03b1\u03bc\u03af\u03bb\u03b7) \u2014 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b1\u03bc\u03bf\u03c1\u03c4\u03b9\u03c0\u03af\u03bd\u03b7\u03c2. \u0391\u03c0\u03bf\u03c6\u03cd\u03b3\u03b5\u03c4\u03b5 \u03c4\u03b7 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c3\u03c5\u03bd\u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03cc\u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03bd\u00b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03ae\u03c3\u03c4\u03b5 \u03c3\u03c4\u03b5\u03bd\u03ac \u03c4\u03b7\u03bd \u03c0\u03af\u03b5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b9\u03ce\u03c3\u03c4\u03b5 \u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03b1\u03bc\u03bf\u03c1\u03c4\u03b9\u03c0\u03af\u03bd\u03b7\u03c2 \u03b5\u03ac\u03bd \u03b5\u03c0\u03b9\u03b4\u03b5\u03b9\u03bd\u03c9\u03b8\u03b5\u03af \u03b7 \u03c5\u03c0\u03cc\u03c4\u03b1\u03c3\u03b7 \u03ae \u03bf\u03b9 \u03bf\u03af\u03b4\u03b7\u03bc\u03b1.<\/li>\n<li><strong>\u0399\u03c3\u03c7\u03c5\u03c1\u03bf\u03af \u03b5\u03c0\u03b1\u03b3\u03c9\u03b3\u03b5\u03af\u03c2 CYP3A4<\/strong> (\u03c1\u03b9\u03c6\u03b1\u03bc\u03c0\u03b9\u03ba\u03af\u03bd\u03b7, \u03ba\u03b1\u03c1\u03b2\u03b1\u03bc\u03b1\u03b6\u03b5\u03c0\u03af\u03bd\u03b7, \u03c6\u03b1\u03b9\u03bd\u03c5\u03c4\u03bf\u0390\u03bd\u03b7, St John\u2019s wort) \u2014 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b1\u03bc\u03bb\u03bf\u03b4\u03b9\u03c0\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03c0\u03af\u03b5\u03c3\u03b7.<\/li>\n<li><strong>\u03a7\u03c5\u03bc\u03cc\u03c2 \u03b3\u03ba\u03c1\u03ad\u03b9\u03c0\u03c6\u03c1\u03bf\u03c5\u03c4<\/strong> \u2014 \u03ae\u03c0\u03b9\u03b1 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03b1\u03bc\u03bb\u03bf\u03b4\u03b9\u03c0\u03af\u03bd\u03b7\u03c2\u00b7 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b7\u03c2 \u03c0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7 (&gt;1 L\/\u03b7\u03bc\u03ad\u03c1\u03b1) \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c5\u03be\u03ae\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03c0\u03af\u03b5\u03c3\u03b7\u00b7 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c4\u03b1\u03c3\u03b9\u03b1\u03ba\u03ae \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bf\u03b4\u03b5\u03ba\u03c4\u03ae.<\/li>\n<li><strong>\u039c\u03b7 \u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ae \u03b1\u03bd\u03c4\u03b9\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 (NSAIDs)<\/strong> \u2014 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03b4\u03cd\u03bf \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd\u00b7 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03bf\u03be\u03b5\u03af\u03b1\u03c2 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b2\u03bb\u03ac\u03b2\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03bf\u03bd ARB.<\/li>\n<li><strong>\u03a0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b5\u03c2 \u03ba\u03b1\u03bb\u03af\u03bf\u03c5, \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03c0\u03bf\u03c5 \u03b5\u03be\u03bf\u03b9\u03ba\u03bf\u03bd\u03bf\u03bc\u03bf\u03cd\u03bd \u03ba\u03ac\u03bb\u03b9\u03bf (\u03c3\u03c0\u03b9\u03c1\u03bf\u03bd\u03bf\u03bb\u03b1\u03ba\u03c4\u03cc\u03bd\u03b7, \u03b5\u03c0\u03bb\u03b5\u03c1\u03b5\u03bd\u03cc\u03bd\u03b7, \u03b1\u03bc\u03b9\u03bb\u03bf\u03c1\u03af\u03b4\u03b7)<\/strong> \u2014 \u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b7 \u03c5\u03c0\u03b5\u03c1\u03ba\u03b1\u03bb\u03b9\u03b1\u03b9\u03bc\u03af\u03b1\u00b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03ae\u03c3\u03c4\u03b5 \u03c3\u03c4\u03b5\u03bd\u03ac.<\/li>\n<li><strong>\u039b\u03b9\u03b8\u03b9\u03bf<\/strong> \u2014 \u03bf\u03b9 ARBs \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bb\u03b9\u03b8\u03af\u03bf\u03c5\u00b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03ae\u03c3\u03c4\u03b5 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b5\u03ac\u03bd \u03bf \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c0\u03cc\u03c6\u03b5\u03c5\u03ba\u03c4\u03bf\u03c2.<\/li>\n<li><strong>\u03a4\u03b1\u03ba\u03c1\u03bf\u03bb\u03af\u03bc\u03bf\u03c5\u03c2, \u03ba\u03c5\u03ba\u03bb\u03bf\u03c3\u03c0\u03bf\u03c1\u03af\u03bd\u03b7<\/strong> \u2014 \u03b7 \u03b1\u03bc\u03bb\u03bf\u03b4\u03b9\u03c0\u03af\u03bd\u03b7 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03ac \u03c4\u03bf\u03c5\u03c2\u00b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03ae\u03c3\u03c4\u03b5 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b2\u03ac\u03c3\u03b7\u03c2.<\/li>\n<li><strong>\u0386\u03bb\u03bb\u03bf\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u039c\u0395\u0391, \u03ac\u03bb\u03bb\u03b1 ARB, \u03b1\u03bb\u03b9\u03c3\u03ba\u03b9\u03c1\u03ad\u03bd<\/strong> \u2014 \u03bc\u03b7\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03b5\u03c4\u03b5.<\/li>\n<li><strong>\u03a3\u03b9\u03bb\u03b4\u03b5\u03bd\u03b1\u03c6\u03af\u03bb\u03b7, \u03c4\u03b1\u03b4\u03b1\u03bb\u03b1\u03c6\u03af\u03bb\u03b7, \u03b1-\u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2<\/strong> \u2014 \u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b7 \u03c5\u03c0\u03cc\u03c4\u03b1\u03c3\u03b7. \u03a7\u03c9\u03c1\u03b9\u03c3\u03c4\u03ae \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u00b7 \u03be\u03b5\u03ba\u03b9\u03bd\u03ae\u03c3\u03c4\u03b5 \u03bc\u03b5 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 PDE5 (\u03c3\u03b9\u03bb\u03b4\u03b5\u03bd\u03b1\u03c6\u03af\u03bb\u03b7 25 mg\u00b7 \u03c4\u03b1\u03b4\u03b1\u03bb\u03b1\u03c6\u03af\u03bb\u03b7 5 mg).<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Olmezest AM vs ARB+Thiazide Combinations<\/h2>\n<p>\u039a\u03b1\u03b9 \u03bf\u03b9 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03af ARB+CCB \u03ba\u03b1\u03b9 ARB+\u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03af \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2 \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2. \u0392\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2:<\/p>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u03a0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">ARB + CCB (Olmezest AM)<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">ARB + HCTZ (\u03c0.\u03c7. Telma H)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0391\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0399\u03c3\u03c7\u03c5\u03c1\u03cc\u03c4\u03b5\u03c1\u03bf (ACCOMPLISH)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u039c\u03ad\u03c4\u03c1\u03b9\u03bf<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">\u039c\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u039f\u03c5\u03b4\u03ad\u03c4\u03b5\u03c1\u03bf<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0395\u03c0\u03b9\u03b4\u03b5\u03b9\u03bd\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7, \u03c4\u03bf \u03bf\u03c5\u03c1\u03b9\u03ba\u03cc \u03bf\u03be\u03cd, \u03c4\u03b1 \u03bb\u03b9\u03c0\u03af\u03b4\u03b9\u03b1<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u039a\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03bf \u03c3\u03b5 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7, \u03bf\u03c5\u03c1\u03b9\u03ba\u03ae \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1, \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03cc \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u039d\u03b1\u03b9 (\u03c0\u03c1\u03bf\u03c4\u03b9\u03bc\u03ce\u03bc\u03b5\u03bd\u03bf)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u039d\u03b1\u03b9 \u03b1\u03bb\u03bb\u03ac \u03b5\u03c0\u03b9\u03b4\u03b5\u03b9\u03bd\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7\/\u03bf\u03c5\u03c1\u03b9\u03ba\u03cc \u03bf\u03be\u03cd<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">\u039f\u03af\u03b4\u03b7\u03bc\u03b1 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03c4\u03c1\u03b1\u03b3\u03ac\u03bb\u03bf\u03c5\u03c2<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Possible (less than amlodipine alone)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u038c\u03c7\u03b9<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Electrolyte disturbance<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Minimal<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Hypokalaemia, hyponatraemia possible<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">CKD (eGFR 30-60)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Effective<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">HCTZ loses efficacy at low GFR<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Preferred when<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Diabetes, gout, CKD, metabolic syndrome, Black patients<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Volume-expanded states, resistant HTN<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Bottom line: for most younger patients with uncomplicated hypertension who need a two-drug combination, ARB+CCB (Olmezest AM) has a slight edge in CV outcome evidence and metabolic profile. ARB+HCTZ remains first choice in volume-expanded states (salt-sensitive hypertension, obesity, Black patients &mdash; though amlodipine is also strongly effective in Black patients) and in resistant hypertension requiring triple therapy.<\/p>\n<h2 class=\"wp-block-heading\">\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7<\/h2>\n<p>Store Olmezest AM below 25&deg;C in the original blister pack. Keep out of reach of children.<\/p>\n<h2 id=\"faqs\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3 class=\"wp-block-heading\">Why combine olmesartan with amlodipine in one pill?<\/h3>\n<p>Two reasons. First, <strong>additive blood-pressure reduction<\/strong>: the two drugs act on complementary pathways (angiotensin receptor and L-type calcium channel), producing 10-15 mmHg more systolic BP drop than either agent alone. Second, and less obviously, <strong>adding the ARB to amlodipine roughly halves the ankle-oedema rate<\/strong> &mdash; the ARB&rsquo;s venous dilation rebalances amlodipine&rsquo;s arteriolar dilation, improving capillary hydrostatic pressure. ACCOMPLISH trial evidence shows lower cardiovascular events on ARB+amlodipine than on ARB+HCTZ in high-risk patients.<\/p>\n<h3 class=\"wp-block-heading\">Will Olmezest AM cause ankle swelling?<\/h3>\n<p>Possibly &mdash; but <strong>less often than amlodipine monotherapy<\/strong>. Amlodipine alone causes ankle oedema in 10-20% of patients. Adding olmesartan drops that rate to roughly 5-10%. Oedema is typically mild, non-progressive, and <strong>does not respond to diuretics<\/strong> (it is capillary-hydrostatic not volume-overload). If oedema is troublesome, options are: reduce amlodipine to 5 mg (20\/5 tablet), switch to a non-DHP CCB (diltiazem), or switch to an ARB+thiazide combination.<\/p>\n<h3 class=\"wp-block-heading\">When should I take Olmezest AM?<\/h3>\n<p>Once daily at the same time each day. <strong>Time of day does not matter clinically<\/strong> for Olmezest AM &mdash; both olmesartan (13-hour half-life) and amlodipine (30-50-hour half-life) give 24-hour BP coverage. Morning dosing is most convenient for most patients; evening dosing is occasionally used in patients who do not show normal nocturnal BP dipping.<\/p>\n<h3 class=\"wp-block-heading\">I&rsquo;m diabetic &mdash; is Olmezest AM safe?<\/h3>\n<p>Yes &mdash; ARB+amlodipine is a <strong>preferred combination in diabetes<\/strong> because it is metabolically neutral (does not worsen glucose tolerance, lipids, or urate, unlike thiazides). Olmesartan has dedicated diabetic nephropathy evidence (ROADMAP). Monitor renal function and potassium as usual.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Olmezest AM with a statin?<\/h3>\n<p>Mostly yes, with one caveat: <strong>simvastatin dose must not exceed 20 mg daily<\/strong> when taken with amlodipine (amlodipine raises simvastatin exposure and increases rhabdomyolysis risk). Rosuvastatin (<a href=\"https:\/\/medsbase.com\/el\/rosu-hdl\/\">Rosu-HDL<\/a>), atorvastatin up to 40 mg, and pravastatin are unaffected by amlodipine and can be used at any dose.<\/p>\n<h3 class=\"wp-block-heading\">Can I eat grapefruit while taking Olmezest AM?<\/h3>\n<p>Occasional grapefruit is fine. Large habitual intake (more than about 1 litre of juice daily) can modestly raise amlodipine levels via CYP3A4 inhibition, potentially worsening BP drop or ankle oedema. Other dihydropyridines (felodipine especially) are much more grapefruit-sensitive; amlodipine&rsquo;s interaction is relatively mild.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Olmezest AM in pregnancy?<\/h3>\n<p><strong>\u038c\u03c7\u03b9 \u2014 \u03b1\u03c0\u03bf\u03bb\u03cd\u03c4\u03c9\u03c2 \u03b1\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03b5\u03c4\u03b1\u03b9.<\/strong> Olmesartan is teratogenic (fetal renal agenesis, oligohydramnios, pulmonary hypoplasia, skull defects). Amlodipine alone has been used in pregnancy (there is modest safety data) but the olmesartan component makes Olmezest AM unsuitable. Switch to <a href=\"https:\/\/medsbase.com\/el\/labebet\/\">\u03bb\u03b1\u03b2\u03b5\u03c4\u03b1\u03bb\u03cc\u03bb\u03b7<\/a>, methyldopa, or nifedipine (monotherapy) before conception.<\/p>\n<h3 class=\"wp-block-heading\">\u03a4\u03b9 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03bd \u03c7\u03ac\u03c3\u03c9 \u03bc\u03b9\u03b1 \u03b4\u03cc\u03c3\u03b7;<\/h3>\n<p>Take it as soon as you remember, unless your next dose is within a few hours &mdash; in that case skip the missed dose. Do not double up. Amlodipine&rsquo;s long half-life makes BP control quite forgiving of a single missed dose; several consecutive missed days will allow BP to climb back.<\/p>\n<h3 class=\"wp-block-heading\">I developed chronic diarrhoea on Olmezest AM &mdash; what should I do?<\/h3>\n<p>Investigate for <strong>olmesartan-associated sprue-like enteropathy<\/strong> &mdash; a rare but recognised complication (FDA 2013 warning), presenting as chronic diarrhoea, weight loss, and villous atrophy mimicking coeliac disease. Resolves after stopping olmesartan. Switch to a different ARB (telmisartan, valsartan, losartan) or a different class entirely.<\/p>\n<h3 class=\"wp-block-heading\">Where can I buy Olmezest AM online?<\/h3>\n<p>You can buy Olmezest AM (20\/5 mg olmesartan + amlodipine, 30-180 tablets) from MedsBase with discreet packaging and worldwide shipping.<\/p>\n<h2 class=\"wp-block-heading\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u0391\u03bd\u03c4\u03b9\u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/amlode\/\">Amlode \u2014 Amlodipine 5\/10 mg (CCB)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/aquazide\/\">Aquazide \u2014 Hydrochlorothiazide<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/coversyl\/\">Coversyl &mdash; Perindopril (ACEi alternative)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/losatec-h\/\">Losatec H \u2014 Losartan + HCTZ<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/telmaheal\/\">Telmaheal \u2014 Telmisartan 20\/40\/80 mg (\u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/valzaar-h\/\">Valzaar H &mdash; Valsartan + HCTZ<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/high-blood-pressure-medication\/\"><strong>\u03a0\u03b5\u03c1\u03b9\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c3\u03b5 \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03a6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b3\u03b9\u03b1 \u03a5\u03c8\u03b7\u03bb\u03ae \u03a0\u03af\u03b5\u03c3\u03b7 \u0391\u03af\u03bc\u03b1\u03c4\u03bf\u03c2<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 \u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u0391\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u0395\u03c5\u03b8\u03cd\u03bd\u03b7\u03c2.<\/strong> \u0391\u03c5\u03c4\u03ae \u03b7 \u03c3\u03b5\u03bb\u03af\u03b4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b3\u03b9\u03b1 \u03b5\u03bd\u03b7\u03bc\u03b5\u03c1\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c3\u03ba\u03bf\u03c0\u03bf\u03cd\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03c4\u03b7\u03bd \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03ae \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1\u03bd \u03ba\u03b1\u03c4\u03b1\u03be\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b1\u03b3\u03b3\u03b5\u03bb\u03bc\u03b1\u03c4\u03af\u03b1 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2. \u0397 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7, \u03b7 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03b1\u03c1\u03c1\u03c5\u03b8\u03bc\u03af\u03b5\u03c2 \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7, \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03b4\u03cc\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc \u2014 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b5 \u03b2-\u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c5\u03c0\u03cc \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b2\u03bb\u03b5\u03c8\u03b7.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2<\/h3>\n<p>\u0386\u03bb\u03bb\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 \u03c3\u03b5 <strong>\u03a7\u03c1\u03cc\u03bd\u03b9\u03b5\u03c2 \u03a0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2<\/strong> \u03c0\u03bf\u03c5 \u03bf\u03b9 \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/healmaryl\/\">Healmaryl<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/asthalin\/\">Asthalin<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/pirox-dt\/\">Pirox DT<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/glinil-m\/\">Glinil M<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/lispro\/\">Lispro<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Olmezest AM is Mankind Pharma&#8217;s fixed-dose olmesartan 20 mg + amlodipine 5 mg tablets \u2014 metabolically-neutral ARB+CCB combination backed by ACCOMPLISH trial evidence (20% lower CV events vs ARB+thiazide in high-risk hypertension). Uniquely, adding olmesartan to amlodipine roughly halves the amlodipine ankle-oedema rate \u2014 the ARB&#8217;s venous dilation rebalances amlodipine&#8217;s arteriolar dilation. Preferred combination in diabetes, gout, and metabolic syndrome.<\/p>","protected":false},"featured_media":59864,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3342,3260,3356],"product_tag":[3362,3427,4755],"class_list":{"0":"post-59863","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-general-health","9":"product_cat-heart-blood-pressure","10":"product_cat-high-blood-pressure-medication","11":"product_tag-amlodipine","12":"product_tag-olmesartan","13":"product_tag-olmezest-am","15":"first","16":"instock","17":"shipping-taxable","18":"purchasable","19":"product-type-variable","20":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/59863","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=59863"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/59864"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=59863"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=59863"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=59863"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=59863"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}