{"id":60137,"date":"2024-02-28T06:35:09","date_gmt":"2024-02-28T06:35:09","guid":{"rendered":"https:\/\/medsname.com\/psyquit\/"},"modified":"2026-05-01T10:49:15","modified_gmt":"2026-05-01T10:49:15","slug":"psyquit","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/psyquit\/","title":{"rendered":"Psyquit"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Psyquit?<\/h3>\n<div style=\"margin:0;\">\n<p style=\"margin:0;\"><strong>Psyquit<\/strong> \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 <strong>quetiapine 25 \/ 100 \/ 200 mg (immediate-release)<\/strong> from a WHO-GMP certified manufacturer (Sun Pharma) &mdash; an <strong>atypical antipsychotic<\/strong> with broad use across schizophrenia, bipolar disorder, and treatment-resistant depression. Mechanism: D2 + 5-HT<sub>2A<\/sub> antagonism plus prominent H<sub>1<\/sub> antihistamine action (heavy sedation) plus alpha-1 blockade (orthostasis). Doses span a huge range by indication: <strong>25&ndash;100 mg HS<\/strong> (off-label insomnia, anxiety adjunct &mdash; controversial), <strong>300&ndash;800 mg\/day<\/strong> (schizophrenia, bipolar mania), <strong>150&ndash;300 mg\/day<\/strong> (bipolar depression, MDD adjunct). <strong>Major class warnings<\/strong>: metabolic syndrome (weight, glucose, lipids &mdash; class effect), heavy sedation, orthostatic hypotension, QT prolongation, EPS (lower than first-generation antipsychotics), and FDA <strong>black box for elderly dementia mortality<\/strong>.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong> \u03a0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2 WHO-GMP \u00b7 \u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u00b7 \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u00b7 1,400+ \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 <a href=\"https:\/\/medsbase.com\/el\/reviews\/\">\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\"><strong>\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n<h3>\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n<p>\u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 22px 0;border-radius:4px;font-size:14px;\"><strong>Important &mdash; this is not a situational-anxiety medication.<\/strong> Psyquit is a <strong>atypical antipsychotic<\/strong>, prescribed and titrated over weeks for <strong>schizophrenia, bipolar mania and depression, bipolar maintenance, and adjunctive treatment of major depressive disorder<\/strong>. It is <strong>\u03b4\u03b5\u03bd<\/strong> the right drug for acute, performance-related anxiety (flying, public speaking, exams) &mdash; for those use cases beta-blockers (propranolol), benzodiazepines, or hydroxyzine are clinically appropriate. If you do not have a diagnosed mood, anxiety, or psychiatric disorder, do not start this medication.<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 22px 0;border-radius:4px;font-size:14px;\"><strong>FDA black-box warning &mdash; elderly dementia mortality.<\/strong> All antipsychotics (atypical and conventional) carry an FDA black-box warning for increased mortality when used to treat dementia-related psychosis or behavioural disturbance in elderly patients. This medication is <strong>not approved<\/strong> for dementia-related symptoms.<\/div>\n<h2 class=\"wp-block-heading\">What Is Psyquit?<\/h2>\n<p>Psyquit is an oral immediate-release tablet of <strong>quetiapine fumarate 25 \/ 100 \/ 200 mg<\/strong> manufactured by Sun Pharma. Quetiapine (US brand <strong>Seroquel IR \/ Seroquel XR<\/strong>) is an atypical (second-generation) antipsychotic launched by AstraZeneca in 1997. It is a <strong>D<sub>2<\/sub> and 5-HT<sub>2A<\/sub> antagonist with strong H<sub>1<\/sub> antihistamine and moderate alpha-1 antagonist activity<\/strong>. The H<sub>1<\/sub> blockade drives the prominent sedation; the alpha-1 blockade drives orthostatic hypotension; the 5-HT<sub>2A<\/sub> antagonism reduces extrapyramidal side-effect risk compared with first-generation antipsychotics.<\/p>\n<p>\u03a4\u03bf <strong>IR (immediate-release)<\/strong> formulation reaches peak plasma in 1&ndash;2 hours, producing prompt sedation. Dose timing matters &mdash; sedation 1&ndash;3 hours after the dose can be either useful (insomnia adjunct) or limiting (daytime fatigue).<\/p>\n<h2 class=\"wp-block-heading\">\u0395\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03c2 \u0395\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li><strong>Schizophrenia<\/strong> &mdash; acute and maintenance<\/li>\n<li><strong>Bipolar mania<\/strong> &mdash; acute (monotherapy or with lithium \/ valproate)<\/li>\n<li><strong>Bipolar depression<\/strong> &mdash; one of the few drugs FDA-approved for this; first-line in bipolar I depression<\/li>\n<li><strong>Bipolar maintenance<\/strong> &mdash; with lithium or valproate<\/li>\n<li><strong>Adjunctive treatment of MDD<\/strong> &mdash; XR formulation, 150&ndash;300 mg\/day with an antidepressant<\/li>\n<li>Off-label: insomnia (low dose 25&ndash;50 mg), anxiety (controversial &mdash; metabolic risk for non-psychotic anxiety), agitation in dementia (used with caution given black-box warning)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u03a7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b1\u03bd\u03ac \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:0 0 22px 0;font-size:14px;\">\n<thead>\n<tr>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">\u0395\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">\u039e\u03b5\u03ba\u03b9\u03bd\u03ae\u03c3\u03c4\u03b5<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">\u03a3\u03c4\u03cc\u03c7\u03bf\u03c2<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">\u039c\u03ad\u03b3\u03b9\u03c3\u03c4\u03bf<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">\u03a3\u03b7\u03bc\u03b5\u03b9\u03ce\u03c3\u03b5\u03b9\u03c2<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Schizophrenia (IR)<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">50 mg BID<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">400&ndash;800 mg\/day<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">800 mg\/day<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Titrate over 4&ndash;7 days; XR allows once-daily HS dosing<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Bipolar mania (acute)<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">100 mg\/day &times; day 1, increase by 100 mg\/day<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">400&ndash;800 mg\/day<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">800 mg\/day<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Rapid titration to control mania<\/td>\n<\/tr>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Bipolar depression<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">50 mg HS &times; day 1, then 100, 200, 300<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">300 mg\/day at bedtime<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">300 mg\/day<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Standard maximum for this indication<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">MDD adjunct (XR only)<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">50 mg HS<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">150&ndash;300 mg\/day<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">300 mg\/day<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Add to existing antidepressant; sedation often dose-limiting<\/td>\n<\/tr>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Off-label insomnia<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">25&ndash;50 mg HS<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">25&ndash;50 mg HS<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">100 mg HS<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Controversial &mdash; metabolic risk for sleep dose makes this a poor first choice; reserve for patients who have failed multiple alternatives<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">\u0397\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03b9<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">25&ndash;50 mg\/day, slower titration<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">\u2014<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Consider 200&ndash;300 mg\/day max<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Greater sedation and orthostasis &mdash; falls risk<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">\u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/h2>\n<h2 class=\"wp-block-heading\">Side-effect profile by mechanism<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:0 0 22px 0;font-size:14px;\">\n<thead>\n<tr>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">Mechanism<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">Effects<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">Notes \/ management<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Metabolic (5-HT<sub>2C<\/sub> + H<sub>1<\/sub> appetite drive)<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Weight gain (often significant), increased blood glucose \/ new-onset diabetes, dyslipidaemia<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Class warning &mdash; baseline weight, BP, fasting glucose, lipids; reassess at 3 months and annually<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">H<sub>1<\/sub> blockade<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Heavy sedation, drowsiness<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Useful at bedtime; often limiting during the day. Less peak sedation with XR<\/td>\n<\/tr>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Alpha-1 blockade<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">\u039f\u03c1\u03b8\u03bf\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ae \u03c5\u03c0\u03cc\u03c4\u03b1\u03c3\u03b7, \u03b6\u03ac\u03bb\u03b7<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Slow titration; check lying \/ standing BP<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Anticholinergic (mild)<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Dry mouth, constipation<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Less than olanzapine<\/td>\n<\/tr>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">D<sub>2<\/sub> blockade<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Extrapyramidal symptoms (akathisia, parkinsonism, dystonia)<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Lower than first-generation antipsychotics; akathisia at higher doses<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">\u0386\u03bb\u03bb\u03bf<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">\u0395\u03c0\u03ad\u03ba\u03c4\u03b1\u03c3\u03b7 QT<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Baseline ECG; caution with other QT-prolonging drugs<\/td>\n<\/tr>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">\u03a3\u03c0\u03ac\u03bd\u03b9\u03b5\u03c2<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Tardive dyskinesia<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Lower risk than typical antipsychotics but real with long-term use<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">\u03a3\u03c0\u03ac\u03bd\u03b9\u03b5\u03c2<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Neuroleptic malignant syndrome<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Hyperthermia, rigidity, autonomic instability &mdash; emergency<\/td>\n<\/tr>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">\u03a3\u03c0\u03ac\u03bd\u03b9\u03b5\u03c2<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Hyperprolactinaemia<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Less than risperidone<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">\u03a3\u03c0\u03ac\u03bd\u03b9\u03b5\u03c2<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Cataracts<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Lens monitoring controversial; some clinicians order 6-monthly slit-lamp exam<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03a6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd<\/h2>\n<p><strong>CYP3A4 substrate<\/strong>: levels rise with strong inhibitors (ketoconazole, ritonavir, clarithromycin) &mdash; reduce dose. Levels fall with strong inducers (rifampin, phenytoin, carbamazepine) &mdash; loss of efficacy.<\/p>\n<p><strong>Additive sedation<\/strong>: alcohol, benzodiazepines, opioids, sedating antidepressants.<\/p>\n<p><strong>\u0395\u03c0\u03ad\u03ba\u03c4\u03b1\u03c3\u03b7 QT<\/strong>: caution with citalopram (high dose), methadone, ondansetron, fluoroquinolones, ziprasidone.<\/p>\n<p><strong>\u0391\u03bd\u03c4\u03b9\u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03ac<\/strong>: additive orthostasis with alpha-blockers, ACE inhibitors, diuretics.<\/p>\n<p><strong>Anticholinergic burden<\/strong>: additive with diphenhydramine, oxybutynin.<\/p>\n<h2 class=\"wp-block-heading\">Metabolic Monitoring<\/h2>\n<p>All atypical antipsychotics carry a class warning for metabolic syndrome &mdash; weight gain, dyslipidaemia, and impaired glucose tolerance. Quetiapine sits in the higher-risk group (with olanzapine and clozapine). Standard monitoring: <strong>baseline + 3 months + annually<\/strong>: weight \/ BMI, waist circumference, fasting glucose or HbA1c, fasting lipid panel, blood pressure. Consider a switch to a lower-metabolic-risk agent (aripiprazole, lurasidone, ziprasidone) if weight \/ glucose deteriorates.<\/p>\n<h2 id=\"faqs\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3 class=\"wp-block-heading\">How long does Psyquit take to work?<\/h3>\n<p>Acute psychosis or mania symptoms often respond within days; full benefit at 4&ndash;6 weeks. Bipolar depression response typically appears at 1&ndash;3 weeks at the 300 mg target.<\/p>\n<h3 class=\"wp-block-heading\">Why is Psyquit used for sleep?<\/h3>\n<p>Quetiapine 25&ndash;50 mg HS produces heavy sedation through H<sub>1<\/sub> blockade. Off-label sleep use has become widespread but is controversial &mdash; metabolic side effects accumulate even at low dose, and safer hypnotics exist.<\/p>\n<h3 class=\"wp-block-heading\">Will Psyquit make me gain weight?<\/h3>\n<p>Likely yes &mdash; quetiapine is one of the more weight-gain-prone atypicals. Average weight gain at therapeutic doses is 4&ndash;7 kg over 12 months; some patients gain considerably more. Lifestyle interventions help; switching to aripiprazole or lurasidone may be needed if weight becomes problematic.<\/p>\n<h3 class=\"wp-block-heading\">Is Psyquit safe in elderly patients with dementia?<\/h3>\n<p>FDA black-box warning for increased mortality in elderly with dementia-related psychosis or behavioural disturbance. Use only when behavioural and non-pharmacological strategies have failed and the symptoms are severe; lowest dose, shortest duration, with informed consent of family.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol on Psyquit?<\/h3>\n<p>Avoid &mdash; additive sedation and orthostasis. Even moderate alcohol substantially increases sedation and falls risk.<\/p>\n<h3 class=\"wp-block-heading\">What is the difference between IR and XR quetiapine?<\/h3>\n<p>IR peaks at 1&ndash;2 hours; XR peaks at ~6 hours and allows once-daily dosing. IR has more peak sedation just after the dose; XR has a smoother profile. Daily AUC is similar at equivalent doses.<\/p>\n<h3 class=\"wp-block-heading\">Will Psyquit cause extrapyramidal side effects?<\/h3>\n<p>Quetiapine has the lowest EPS risk among atypicals along with clozapine. Akathisia at higher doses is the most common motor side effect; tardive dyskinesia risk exists with long-term use but is much lower than first-generation antipsychotics.<\/p>\n<h3 class=\"wp-block-heading\">Is Psyquit safe in pregnancy?<\/h3>\n<p>Limited data &mdash; quetiapine is one of the better-studied atypicals in pregnancy. Continuation is reasonable when needed for serious mental illness; first-trimester exposure does not appear to increase major malformation rates above baseline.<\/p>\n<h3 class=\"wp-block-heading\">Can I stop Psyquit abruptly?<\/h3>\n<p>Better to taper, especially after long-term use &mdash; abrupt discontinuation can produce withdrawal dyskinesia, insomnia, nausea, sweating, and rebound psychosis or mania. Reduce by 25&ndash;50 mg every 1&ndash;2 weeks.<\/p>\n<h3 class=\"wp-block-heading\">How should Psyquit be stored?<\/h3>\n<p>Store at 15&ndash;30 &deg;C in the original blister packaging, away from moisture and sunlight. Keep out of reach of children.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0 0 0;border-radius:4px;font-size:13.5px;line-height:1.55;\"><strong>\u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03b5\u03c5\u03b8\u03cd\u03bd\u03b7\u03c2:<\/strong> Information on this page is intended for adults using prescribed psychiatric medication and is not a substitute for individualised medical care. Antidepressants, antipsychotics, and related medications can interact with other drugs, alcohol, and pre-existing conditions. Discuss any new medication, dose change, or planned discontinuation with a qualified prescriber. If you experience suicidal thoughts, mania, severe akathisia, signs of serotonin syndrome (high fever, confusion, muscle rigidity, rapid heart rate), or neuroleptic malignant syndrome, seek emergency care immediately.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2<\/h3>\n<p>\u0386\u03bb\u03bb\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 \u03c3\u03b5 <strong>\u03a7\u03c1\u03cc\u03bd\u03b9\u03b5\u03c2 \u03a0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2<\/strong> \u03c0\u03bf\u03c5 \u03bf\u03b9 \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/brom\/\">Brom<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/lipaglyn\/\">Lipaglyn<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/dynapar\/\">Dynapar<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/azoran\/\">Azoran<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/nucoxia-sp\/\">Nucoxia SP<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Manages schizophrenia<br \/>\n\u2705 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b4\u03b9\u03c0\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae\u03c2<br \/>\n\u2705 Controls major depression<br \/>\n\u2705 Reduces anxiety symptoms<br \/>\n\u2705 Improves sleep quality<\/p>\n<p>Psyquit contains Quetiapine<\/p>","protected":false},"featured_media":60138,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,4647],"product_tag":[4815,4619],"class_list":{"0":"post-60137","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-situational-anxiety-treatment","9":"product_tag-psyquit","10":"product_tag-quetiapine","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/60137","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=60137"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/60138"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=60137"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=60137"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=60137"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=60137"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}