{"id":60437,"date":"2024-02-28T06:48:51","date_gmt":"2024-02-28T06:48:51","guid":{"rendered":"https:\/\/medsname.com\/rioci-1\/"},"modified":"2026-05-01T10:49:16","modified_gmt":"2026-05-01T10:49:16","slug":"rioci-1","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/rioci-1\/","title":{"rendered":"Rioci 1"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 \u0393\u03c1\u03ae\u03b3\u03bf\u03c1\u03b7 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u2014 \u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf Rioci 1;<\/h3>\n<p style=\"margin:0;\"><strong>Rioci 1<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03b9\u03c3\u03ba\u03af\u03b1 \u03c1\u03b9\u03bf\u03c3\u03b9\u03b3\u03ba\u03bf\u03c5\u03ac\u03c4 1 mg \u03b1\u03c0\u03cc \u03b5\u03c1\u03b3\u03bf\u03c3\u03c4\u03ac\u03c3\u03b9\u03bf \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd WHO-GMP \u2014 \u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03bb\u03c5\u03c4\u03ae\u03c2 \u03b3\u03bf\u03c5\u03b1\u03bd\u03c5\u03bb\u03b9\u03ba\u03ae\u03c2 \u03ba\u03c5\u03ba\u03bb\u03ac\u03c3\u03b7\u03c2 (sGC) \u03b3\u03b9\u03b1 <strong>\u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 (PAH)<\/strong>. \u0397 PAH \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7, \u03c0\u03c1\u03bf\u03bf\u03b4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03bd\u03cc\u03c3\u03bf\u03c2 \u2014 <strong>\u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03af\u03b4\u03b9\u03bf \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7<\/strong>. \u0391\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03af\u03b5\u03c3\u03b7 \u03c3\u03c4\u03b9\u03c2 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b1\u03c1\u03c4\u03b7\u03c1\u03af\u03b5\u03c2, \u03cc\u03c7\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b9\u03ba\u03ad\u03c2 \u03b1\u03c1\u03c4\u03b7\u03c1\u03af\u03b5\u03c2, \u03ba\u03b1\u03b9 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c5\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03b2\u03bb\u03b5\u03c8\u03b7 \u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd \u03c3\u03b5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03ad\u03bd\u03c4\u03c1\u03bf PAH. \u03a4\u03bf \u03c1\u03b9\u03bf\u03c3\u03b9\u03b3\u03ba\u03bf\u03c5\u03ac\u03c4 \u03b5\u03b9\u03c3\u03ae\u03c7\u03b8\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7 Bayer \u03c4\u03bf 2013 \u03c9\u03c2 <strong>Adempas<\/strong> \u2014 \u03bf \u03c0\u03c1\u03ce\u03c4\u03bf\u03c2 \u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03ae\u03c2 sGC \u03c0\u03bf\u03c5 \u03b5\u03b3\u03ba\u03c1\u03af\u03b8\u03b7\u03ba\u03b5 \u03b3\u03b9\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2. \u0395\u03b3\u03ba\u03c1\u03af\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd FDA \u03b3\u03b9\u03b1 \u03b4\u03cd\u03bf \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7\u03c2: \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 (PAH, WHO \u039f\u03bc\u03ac\u03b4\u03b1 1) \u03ba\u03b1\u03b9 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03b5\u03bc\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 (CTEPH, WHO \u039f\u03bc\u03ac\u03b4\u03b1 4) \u2014 \u03c4\u03bf \u03bc\u03cc\u03bd\u03bf \u03c3\u03ba\u03b5\u03cd\u03b1\u03c3\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c4\u03cc\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03b3\u03ba\u03c1\u03af\u03b8\u03b7\u03ba\u03b5 \u03b3\u03b9\u03b1 \u03bc\u03b7 \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae CTEPH. \u0395\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03ac\u03bc\u03b5\u03c3\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03bb\u03c5\u03c4\u03ae \u03b3\u03bf\u03c5\u03b1\u03bd\u03c5\u03bb\u03b9\u03ba\u03ae \u03ba\u03c5\u03ba\u03bb\u03ac\u03c3\u03b7 (\u03bf \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 NO) \u03c3\u03c4\u03b7\u03bd \u03bb\u03b5\u03af\u03b1 \u03bc\u03c5\u03ca\u03ba\u03ae \u03c4\u03c9\u03bd \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ce\u03bd \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03ce\u03bd, \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf cGMP \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b1\u03b3\u03b3\u03b5\u03b9\u03bf\u03b4\u03b9\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae. \u03a3\u03b5 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 PDE5, \u03c4\u03bf \u03c1\u03b9\u03bf\u03c3\u03b9\u03b3\u03ba\u03bf\u03c5\u03ac\u03c4 \u03b4\u03b9\u03b5\u03b3\u03b5\u03af\u03c1\u03b5\u03b9 \u03c4\u03b7\u03bd sGC \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c5\u03c3\u03af\u03b1 NO, \u03c0\u03b1\u03c1\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03b5 \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ac \u03ba\u03c1\u03b5\u03b2\u03ac\u03c4\u03b9\u03b1 \u03bc\u03b5 \u03ad\u03bb\u03bb\u03b5\u03b9\u03c8\u03b7 NO, \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c4\u03b7\u03c2 PAH \u03ba\u03b1\u03b9 CTEPH. \u0394\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1: \u039e\u03b5\u03ba\u03b9\u03bd\u03ae\u03c3\u03c4\u03b5 \u03bc\u03b5 1 mg \u03c4\u03c1\u03b5\u03b9\u03c2 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03c4\u03b7\u03bd \u03b7\u03bc\u03ad\u03c1\u03b1 (\u03c3\u03b5 \u03b4\u03b9\u03b1\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 8 \u03c9\u03c1\u03ce\u03bd); \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03cc\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03ac\u03b8\u03b5 2 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03ba\u03b1\u03c4\u03ac 0,5 mg \u03b2\u03ac\u03c3\u03b5\u03b9 \u03c3\u03c5\u03c3\u03c4\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2 (\u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03b5\u03af\u03bd\u03b5\u03b9 &gt;95 mmHg) \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd. \u03a3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2 2,5 mg \u03c4\u03c1\u03b5\u03b9\u03c2 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03c4\u03b7\u03bd \u03b7\u03bc\u03ad\u03c1\u03b1. \u0397 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 PAH \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c0\u03bf\u03c5 \u03be\u03b5\u03ba\u03b9\u03bd\u03ac \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc \u03ba\u03ad\u03bd\u03c4\u03c1\u03bf\u00b7 \u03b1\u03c5\u03c4\u03ae \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c0\u03ac\u03b8\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong> \u03a0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2 WHO-GMP \u00b7 \u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u00b7 \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u00b7 1,400+ \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 <a href=\"https:\/\/medsbase.com\/el\/reviews\/\">\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\"><strong>\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n<h3>\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n<p>\u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n<h2 class=\"wp-block-heading\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf Rioci 1;<\/h2>\n<p>\u03a4\u03bf Rioci 1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03b9\u03c3\u03ba\u03af\u03b1 1 mg \u03c1\u03b9\u03bf\u03c3\u03b9\u03b3\u03ba\u03bf\u03c5\u03ac\u03c4 \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd WHO-GMP, \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b5\u03c2 10-180 \u03b4\u03b9\u03c3\u03ba\u03af\u03c9\u03bd. \u0397 \u03c1\u03b9\u03bf\u03c3\u03b9\u03b3\u03ba\u03bf\u03c5\u03ac\u03c4 \u03b5\u03b9\u03c3\u03ae\u03c7\u03b8\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7 Bayer \u03c4\u03bf 2013 \u03c9\u03c2 <strong>Adempas<\/strong> \u2014 \u03bf \u03c0\u03c1\u03ce\u03c4\u03bf\u03c2 \u03b4\u03b9\u03b5\u03b3\u03ad\u03c1\u03c4\u03b7\u03c2 sGC \u03c0\u03bf\u03c5 \u03b5\u03b3\u03ba\u03c1\u03af\u03b8\u03b7\u03ba\u03b5 \u03b3\u03b9\u03b1 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7. \u0395\u03b3\u03ba\u03c1\u03af\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd FDA \u03b3\u03b9\u03b1 \u03b4\u03cd\u03bf \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7\u03c2: \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 (PAH, WHO \u039f\u03bc\u03ac\u03b4\u03b1 1) \u03ba\u03b1\u03b9 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03b5\u03bc\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 (CTEPH, WHO \u039f\u03bc\u03ac\u03b4\u03b1 4) \u2014 \u03c4\u03bf \u03bc\u03cc\u03bd\u03bf \u03c3\u03ba\u03b5\u03cd\u03b1\u03c3\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03b3\u03ba\u03c1\u03af\u03b8\u03b7\u03ba\u03b5 \u03b3\u03b9\u03b1 \u03bc\u03b7 \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03ae\u03c3\u03b9\u03bc\u03b7 CTEPH.<\/p>\n<p><strong>\u0397 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 (PAH) \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7.<\/strong> \u0397 PAH \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03c3\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c0\u03af\u03b5\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 (\u226520 mmHg \u03bc\u03ad\u03c3\u03b7 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03af\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7 \u22652 \u03bc\u03bf\u03bd\u03ac\u03b4\u03b5\u03c2 Wood \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 ESC\/ERS 2022). \u0395\u03af\u03bd\u03b1\u03b9 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 (\u03b5\u03ba\u03c4\u03b9\u03bc\u03ce\u03bc\u03b5\u03bd\u03b7 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 15-50 \u03b1\u03bd\u03ac \u03b5\u03ba\u03b1\u03c4\u03bf\u03bc\u03bc\u03cd\u03c1\u03b9\u03bf \u03b5\u03bd\u03b7\u03bb\u03af\u03ba\u03c9\u03bd), \u03c0\u03c1\u03bf\u03bf\u03b4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03ba\u03b1\u03ba\u03ae \u03c0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7 (\u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 5 \u03b5\u03c4\u03ce\u03bd \u223c30%). \u0397 \u03c3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd PAH \u03ad\u03c7\u03b5\u03b9 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 5 \u03b5\u03c4\u03ce\u03bd \u03c3\u03b5 60-70% \u03c3\u03b5 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03ba\u03ad\u03bd\u03c4\u03c1\u03b1.<\/p>\n<p>\u039f\u03b9 \u03c5\u03c0\u03bf\u03c8\u03ae\u03c6\u03b9\u03bf\u03b9 \u03b3\u03b9\u03b1 Rioci 1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b5\u03af \u03c3\u03b5 \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc \u03ba\u03ad\u03bd\u03c4\u03c1\u03bf PAH \u03bc\u03ad\u03c3\u03c9 \u03ba\u03b1\u03b8\u03b5\u03c4\u03b7\u03c1\u03b9\u03b1\u03c3\u03bc\u03bf\u03cd \u03b4\u03b5\u03be\u03b9\u03ac\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03ac\u03c2, \u03bc\u03b5 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae\u03c2 \u03ba\u03bb\u03ac\u03c3\u03b7\u03c2 WHO\/NYHA II-IV \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 PAH (WHO \u039f\u03bc\u03ac\u03b4\u03b1 1) \u03ae \u2014 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c1\u03b9\u03bf\u03c3\u03b9\u03b3\u03ba\u03bf\u03c5\u03ac\u03c4 \u2014 \u03bc\u03b7 \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03ae\u03c3\u03b9\u03bc\u03b7 \u03ae \u03b5\u03c0\u03af\u03bc\u03bf\u03bd\u03b7 CTEPH (WHO \u039f\u03bc\u03ac\u03b4\u03b1 4). \u0391\u03c5\u03c4\u03cc \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03b3\u03b9\u03b1 \u03c3\u03c5\u03bd\u03b7\u03b8\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 \u03ae \u03b3\u03b9\u03b1 \u03b1\u03c5\u03c4\u03bf-\u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1.<\/p>\n<h2 class=\"wp-block-heading\">\u03a0\u03ce\u03c2 \u039b\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03b7 \u03a1\u03b9\u03bf\u03c3\u03b9\u03b3\u03ba\u03bf\u03c5\u03ac\u03c4<\/h2>\n<p>\u0395\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03ac\u03bc\u03b5\u03c3\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03bb\u03c5\u03c4\u03ae \u03b3\u03bf\u03c5\u03b1\u03bd\u03c5\u03bb\u03b9\u03ba\u03ae \u03ba\u03c5\u03ba\u03bb\u03ac\u03c3\u03b7 (\u03bf \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 NO) \u03c3\u03c4\u03b7\u03bd \u03bb\u03b5\u03af\u03b1 \u03bc\u03c5\u03b9\u03ba\u03ae \u03c4\u03c9\u03bd \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ce\u03bd \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03ce\u03bd, \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf cGMP \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b1\u03b3\u03b3\u03b5\u03b9\u03bf\u03b4\u03b9\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae. \u03a3\u03b5 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 PDE5, \u03b7 \u03c1\u03b9\u03bf\u03c3\u03b9\u03b3\u03ba\u03bf\u03c5\u03ac\u03c4 \u03b4\u03b9\u03b5\u03b3\u03b5\u03af\u03c1\u03b5\u03b9 \u03c4\u03b7\u03bd sGC \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c5\u03c3\u03af\u03b1 NO, \u03c0\u03b1\u03c1\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03b5 \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ac \u03ba\u03c1\u03b5\u03b2\u03ac\u03c4\u03b9\u03b1 \u03bc\u03b5 \u03ad\u03bb\u03bb\u03b5\u03b9\u03c8\u03b7 NO, \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03c2 PAH \u03ba\u03b1\u03b9 CTEPH.<\/p>\n<h2 class=\"wp-block-heading\">\u0391\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03c4\u03b9\u03ba\u03ac \u03a3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1<\/h2>\n<p><strong>PATENT-1 (2013)<\/strong> \u2014 \u03c1\u03b9\u03bf\u03c3\u03b9\u03b3\u03ba\u03bf\u03c5\u03ac\u03c4 \u03c3\u03b5 443 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 PAH\u00b7 \u03b7 \u03b1\u03c0\u03cc\u03c3\u03c4\u03b1\u03c3\u03b7 6-\u03bb\u03b5\u03c0\u03c4\u03bf\u03c5 \u03c0\u03b5\u03c1\u03c0\u03ac\u03c4\u03b7\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03b8\u03b7\u03ba\u03b5 \u03ba\u03b1\u03c4\u03ac 30 m \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03bf\u03cd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5, \u03bc\u03b5 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae \u03ba\u03bb\u03ac\u03c3\u03b7 WHO \u03ba\u03b1\u03b9 \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03b5\u03c1\u03b7\u03bc\u03ad\u03bd\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b4\u03b5\u03af\u03bd\u03c9\u03c3\u03b7. <strong>CHEST-1 (2013)<\/strong> \u2014 \u03c1\u03b9\u03bf\u03c3\u03b9\u03b3\u03ba\u03bf\u03c5\u03ac\u03c4 \u03c3\u03b5 261 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03bc\u03b7 \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03ae\u03c3\u03b9\u03bc\u03b7 \u03ae \u03b5\u03c0\u03af\u03bc\u03bf\u03bd\u03b7 CTEPH\u00b7 \u03b7 \u03b1\u03c0\u03cc\u03c3\u03c4\u03b1\u03c3\u03b7 6-\u03bb\u03b5\u03c0\u03c4\u03bf\u03c5 \u03c0\u03b5\u03c1\u03c0\u03ac\u03c4\u03b7\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03b8\u03b7\u03ba\u03b5 \u03ba\u03b1\u03c4\u03ac 46 m \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03bf\u03cd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5.<\/p>\n<h2 class=\"wp-block-heading\">\u0394\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7<\/h2>\n<p><strong>\u0394\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1:<\/strong> \u039e\u03b5\u03ba\u03b9\u03bd\u03ae\u03c3\u03c4\u03b5 \u03bc\u03b5 1 mg \u03c4\u03c1\u03b5\u03b9\u03c2 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03b7\u03bc\u03b5\u03c1\u03b7\u03c3\u03af\u03c9\u03c2 (\u03bc\u03b5 \u03b4\u03b9\u03b1\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 8 \u03c9\u03c1\u03ce\u03bd)\u00b7 \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03cc\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03ac\u03b8\u03b5 2 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03bc\u03b5 \u03b1\u03c5\u03be\u03ae\u03c3\u03b5\u03b9\u03c2 0,5 mg \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b7\u03bd \u03c3\u03c5\u03c3\u03c4\u03bf\u03bb\u03b9\u03ba\u03ae \u03c0\u03af\u03b5\u03c3\u03b7 (\u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03b5\u03af\u03bd\u03b5\u03b9 &gt;95 mmHg) \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1. \u03a3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2 2,5 mg \u03c4\u03c1\u03b5\u03b9\u03c2 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03b7\u03bc\u03b5\u03c1\u03b7\u03c3\u03af\u03c9\u03c2.<\/p>\n<p><strong>\u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7:<\/strong> \u03c3\u03c4\u03b7 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae \u03ba\u03b1\u03b9 \u03ba\u03ac\u03b8\u03b5 3-6 \u03bc\u03ae\u03bd\u03b5\u03c2 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u2014 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 WHO, \u03b1\u03c0\u03cc\u03c3\u03c4\u03b1\u03c3\u03b7 6-\u03bb\u03b5\u03c0\u03c4\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03c0\u03ac\u03c4\u03bf\u03c5, NT-proBNP, \u03b5\u03c0\u03b1\u03bd\u03b1\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae \u03b7\u03c7\u03bf\u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1 \u03ba\u03b1\u03b9 (\u03c3\u03b5 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03b4\u03b9\u03b1\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1) \u03ba\u03b1\u03b8\u03b5\u03c4\u03b7\u03c1\u03b9\u03b1\u03c3\u03bc\u03cc\u03c2 \u03b4\u03b5\u03be\u03b9\u03ac\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03ac\u03c2. \u038c\u03bb\u03b1 \u03b3\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf\u03c5 \u03ba\u03ad\u03bd\u03c4\u03c1\u03bf\u03c5 \u03a0\u0391\u03a5.<\/p>\n<p><strong>\u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2:<\/strong> \u03b7 \u03c3\u03c5\u03c3\u03c4\u03bf\u03bb\u03b9\u03ba\u03ae \u03c0\u03af\u03b5\u03c3\u03b7 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03b5\u03af\u03bd\u03b5\u03b9 &gt;95 mmHg\u00b7 \u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2 \u03b4\u03b9\u03b1\u03ba\u03cc\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03c1\u03ad\u03c6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03bf\u03c4\u03cc\u03bd\u03c3\u03b7\u03c2.<\/p>\n<h2 class=\"wp-block-heading\">\u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/h2>\n<ul>\n<li><strong>\u03a5\u03c0\u03bf\u03c4\u03b1\u03c3\u03af\u03b1<\/strong> \u2014 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c4\u03b7\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2\u00b7 \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03b1\u03c1\u03b3\u03ac.<\/li>\n<li><strong>\u0391\u03b9\u03bc\u03bf\u03c0\u03c4\u03c5\u03af\u03b1<\/strong> \u2014 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03c3\u03b5 CTEPH.<\/li>\n<li>\u03a3\u03c5\u03b3\u03ba\u03bf\u03c0\u03ae<\/li>\n<li>\u039a\u03b5\u03c6\u03b1\u03bb\u03b1\u03bb\u03b3\u03af\u03b1, \u03b6\u03ac\u03bb\u03b7<\/li>\n<li>\u03a0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03cc \u03bf\u03af\u03b4\u03b7\u03bc\u03b1<\/li>\n<li>\u0391\u03bd\u03b1\u03b9\u03bc\u03af\u03b1<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u0391\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li><strong>\u03a4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03c9\u03bd PDE5<\/strong> (\u03c3\u03b9\u03bb\u03b4\u03b5\u03bd\u03b1\u03c6\u03af\u03bb\u03b7, \u03c4\u03b1\u03b4\u03b1\u03bb\u03b1\u03c6\u03af\u03bb\u03b7) \u2014 \u03b1\u03b8\u03c1\u03bf\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 cGMP, \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03c5\u03c0\u03bf\u03c4\u03bf\u03bd\u03af\u03b1. \u0391\u03c0\u03b1\u03b3\u03bf\u03c1\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2.<\/li>\n<li><strong>\u03a4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03bd\u03b9\u03c4\u03c1\u03b9\u03ba\u03ce\u03bd \u03ae \u03b4\u03bf\u03c4\u03ce\u03bd NO<\/strong> \u2014 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03af\u03b4\u03b9\u03bf \u03bb\u03cc\u03b3\u03bf\u00b7 \u03b1\u03c0\u03b1\u03b3\u03bf\u03c1\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7.<\/li>\n<li>\u0395\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7 \u2014 \u03b5\u03bc\u03b2\u03c1\u03c5\u03bf\u03b5\u03bc\u03b2\u03c1\u03c5\u03b9\u03ba\u03ae \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 (\u03c0\u03c1\u03cc\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 REMS \u03c3\u03c4\u03b9\u03c2 \u0397\u03a0\u0391: \u03bf\u03b9 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ac, \u03bc\u03b7\u03bd\u03b9\u03b1\u03af\u03bf \u03c4\u03b5\u03c3\u03c4 \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7\u03c2)<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3 class=\"wp-block-heading\">\u0397 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03af\u03b4\u03b9\u03bf \u03bc\u03b5 \u03c4\u03b7\u03bd \u201c\u03c5\u03c8\u03b7\u03bb\u03ae \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03af\u03b5\u03c3\u03b7\u201d;<\/h3>\n<p>\u038c\u03c7\u03b9. \u0397 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c0\u03af\u03b5\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03c3\u03c5\u03c7\u03bd\u03ae\u00b7 \u03b7 \u03a0\u0391\u03a5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c0\u03af\u03b5\u03c3\u03b7 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03c3\u03c4\u03b7\u03bd \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1. \u0388\u03c7\u03bf\u03c5\u03bd \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03b9\u03c4\u03af\u03b5\u03c2, \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd\u03c2 (\u03b7 \u03c6\u03c1\u03bf\u03bd\u03c4\u03af\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03a0\u0391\u03a5 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b1\u03c0\u03cc \u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2\/\u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u03c3\u03b5 \u03c4\u03c1\u03b9\u03c4\u03bf\u03b2\u03ac\u03b8\u03bc\u03b9\u03b1 \u03ba\u03ad\u03bd\u03c4\u03c1\u03b1) \u03ba\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2. \u0388\u03bd\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03c0\u03bf\u03c5 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c0\u03af\u03b5\u03c3\u03b7 (ACEi, ARB, CCB, \u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b9\u03bf) \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b9\u03ba\u03c1\u03ae \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03a0\u0391\u03a5.<\/p>\n<h3 class=\"wp-block-heading\">\u0393\u03b9\u03b1\u03c4\u03af \u03c4\u03bf Rioci 1 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7;<\/h3>\n<p>\u0397 \u03a0\u0391\u03a5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c0\u03ac\u03b8\u03b7\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b1\u03c7\u03b5\u03b9\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc\u03c2 \u03bc\u03b5 \u03ad\u03bd\u03b1 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03bf \u03b5\u03c0\u03b9\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b7\u03c4\u03c1\u03ce\u03bf \u03c3\u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c7\u03ce\u03c1\u03b5\u03c2. \u03a4\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03ba\u03c1\u03b9\u03b2\u03ac, \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 (\u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b7\u03c0\u03b1\u03c4\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b1 ERA \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03c4\u03cc\u03bd\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03b4\u03b9\u03b5\u03b3\u03ad\u03c1\u03c4\u03b5\u03c2 sGC) \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03c4\u03b7\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2 \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b4\u03b9\u03b1\u03b4\u03bf\u03c7\u03b9\u03ba\u03ad\u03c2 \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03ae\u03c3\u03b5\u03b9\u03c2 (6-\u03bb\u03b5\u03c0\u03c4\u03bf \u03c0\u03b5\u03c1\u03c0\u03ac\u03c4\u03b7\u03bc\u03b1, \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae \u03c4\u03ac\u03be\u03b7, NT-proBNP, \u03b7\u03c7\u03bf\u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1). \u0397 \u03b1\u03c5\u03c4\u03bf\u03b4\u03b9\u03b1\u03c7\u03b5\u03af\u03c1\u03b9\u03c3\u03b7 \u03b5\u03ba\u03c4\u03cc\u03c2 \u03b5\u03c4\u03b9\u03ba\u03ad\u03c4\u03b1\u03c2 \u03c3\u03c5\u03bd\u03b5\u03c0\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd\u03c2 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b5\u03af\u03bd\u03c9\u03c3\u03b7\u03c2.<\/p>\n<h3 class=\"wp-block-heading\">\u039c\u03c0\u03bf\u03c1\u03ce \u03bd\u03b1 \u03c0\u03ac\u03c1\u03c9 \u03c4\u03bf Rioci 1 \u03bc\u03b5 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b3\u03b9\u03b1 \u03c3\u03c4\u03c5\u03c4\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1;<\/h3>\n<p><strong>\u038c\u03c7\u03b9 \u2014 \u03b1\u03c0\u03bf\u03bb\u03cd\u03c4\u03c9\u03c2 \u03b1\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03b5\u03c4\u03b1\u03b9.<\/strong> \u039f\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 PDE5 (\u03c3\u03b9\u03bb\u03b4\u03b5\u03bd\u03b1\u03c6\u03af\u03bb\u03b7, \u03c4\u03b1\u03b4\u03b1\u03bb\u03b1\u03c6\u03af\u03bb\u03b7, \u03b2\u03b1\u03c1\u03b4\u03b5\u03bd\u03b1\u03c6\u03af\u03bb\u03b7) \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03c4\u03bf \u03c1\u03b9\u03bf\u03c3\u03b9\u03b3\u03ba\u03bf\u03c5\u03ac\u03c4 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03b1\u03b8\u03c1\u03bf\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c4\u03bf\u03bd\u03af\u03b1. \u0395\u03ac\u03bd \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c3\u03c4\u03b5 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c3\u03c4\u03c5\u03c4\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1, \u03c3\u03c5\u03b6\u03b7\u03c4\u03ae\u03c3\u03c4\u03b5 \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bb\u03cd\u03c3\u03b5\u03b9\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 PAH \u03c3\u03b1\u03c2\u00b7 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 PAH \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 PDE5 \u03b1\u03bd\u03c4\u03af \u03b3\u03b9\u03b1 \u03c1\u03b9\u03bf\u03c3\u03b9\u03b3\u03ba\u03bf\u03c5\u03ac\u03c4 \u03c9\u03c2 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03cc \u03b1\u03b3\u03b3\u03b5\u03b9\u03bf\u03b4\u03b9\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03cc.<\/p>\n<h3 class=\"wp-block-heading\">\u039c\u03c0\u03bf\u03c1\u03ce \u03bd\u03b1 \u03c0\u03ac\u03c1\u03c9 \u03c4\u03bf Rioci 1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7;<\/h3>\n<p><strong>\u038c\u03c7\u03b9.<\/strong> \u03a4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03b5 \u03b5\u03bc\u03b2\u03c1\u03c5\u03bf\u03ad\u03bc\u03b2\u03c1\u03c5\u03b1 \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c3\u03b5 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03b5 \u03b6\u03ce\u03b1\u00b7 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03c4\u03b5\u03c3\u03c4 \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7.<\/p>\n<h3 class=\"wp-block-heading\">\u03a0\u03bf\u03cd \u03bc\u03c0\u03bf\u03c1\u03ce \u03bd\u03b1 \u03b1\u03b3\u03bf\u03c1\u03ac\u03c3\u03c9 \u03c4\u03bf Rioci 1 online;<\/h3>\n<p>\u039c\u03c0\u03bf\u03c1\u03b5\u03af\u03c4\u03b5 \u03bd\u03b1 \u03b1\u03b3\u03bf\u03c1\u03ac\u03c3\u03b5\u03c4\u03b5 \u03c4\u03bf Rioci 1 (riociguat 1 mg, 10-180 \u03b4\u03b9\u03c3\u03ba\u03af\u03b1) \u03b1\u03c0\u03cc \u03c4\u03bf MedsBase \u03bc\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae.<\/p>\n<h2 class=\"wp-block-heading\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u039a\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ac \u03a6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/cardace\/\">Cardace \u2014 Ramipril (ACE \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1\u03c2)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/ecopril\/\">Ecopril \u2014 Clopidogrel 75 mg (\u03b1\u03bd\u03b9\u03b9\u03b1\u03ba\u03bf\u03c3\u03c5\u03c3\u03c3\u03c9\u03c1\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/ecosprin\/\">Ecosprin \u2014 \u0391\u03c3\u03c0\u03b9\u03c1\u03af\u03bd\u03b7 75\/150 mg (\u03b1\u03bd\u03b9\u03b8\u03c1\u03c9\u03c0\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/lonitab\/\">Lonitab \u2014 Minoxidil 5 mg (\u03c3\u03c4\u03bf\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03b1\u03b3\u03b3\u03b5\u03b9\u03bf\u03b4\u03b9\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03cc)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/waf-5\/\">Waf-5 \u2014 Warfarin 5 mg (VKA)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/xarelto-20\/\">Xarelto 20 \u2014 Rivaroxaban 20 mg (DOAC)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/high-blood-pressure-medication\/\"><strong>\u03a0\u03b5\u03c1\u03b9\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c3\u03b5 \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03a6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b3\u03b9\u03b1 \u03a5\u03c8\u03b7\u03bb\u03ae \u03a0\u03af\u03b5\u03c3\u03b7 \u0391\u03af\u03bc\u03b1\u03c4\u03bf\u03c2<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 \u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u0391\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u0395\u03c5\u03b8\u03cd\u03bd\u03b7\u03c2.<\/strong> \u0391\u03c5\u03c4\u03ae \u03b7 \u03c3\u03b5\u03bb\u03af\u03b4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b3\u03b9\u03b1 \u03b5\u03bd\u03b7\u03bc\u03b5\u03c1\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c3\u03ba\u03bf\u03c0\u03bf\u03cd\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03c4\u03b7\u03bd \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03ae \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1\u03bd \u03ba\u03b1\u03c4\u03b1\u03be\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b1\u03b3\u03b3\u03b5\u03bb\u03bc\u03b1\u03c4\u03af\u03b1 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2. \u0397 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7, \u03b7 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03b1\u03c1\u03c1\u03c5\u03b8\u03bc\u03af\u03b5\u03c2 \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7, \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03b4\u03cc\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc \u2014 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b5 \u03b2-\u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c5\u03c0\u03cc \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b2\u03bb\u03b5\u03c8\u03b7.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2<\/h3>\n<p>\u0386\u03bb\u03bb\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 \u03c3\u03b5 <strong>\u03a7\u03c1\u03cc\u03bd\u03b9\u03b5\u03c2 \u03a0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2<\/strong> \u03c0\u03bf\u03c5 \u03bf\u03b9 \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/seretra\/\">Seretra<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/proclid-5\/\">Proclid 5<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/tacroz-forte-ointment\/\">Tacroz Forte Ointment<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/syndopa\/\">Syndopa<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/caditam\/\">\u039a\u03b1\u03bd\u03c4\u03b9\u03c4\u03ac\u03bc<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u03a4\u03bf Rioci 1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03b9\u03c3\u03ba\u03af\u03b1 \u03c1\u03b9\u03bf\u03c3\u03b9\u03b3\u03ba\u03bf\u03c5\u03ac\u03c4 1 mg \u2014 \u03bf \u03c0\u03c1\u03ce\u03c4\u03bf\u03c2 \u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03bb\u03c5\u03c4\u03ae\u03c2 \u03b3\u03bf\u03c5\u03b1\u03bd\u03c5\u03bb\u03b9\u03ba\u03ae\u03c2 \u03ba\u03c5\u03ba\u03bb\u03ac\u03c3\u03b7\u03c2 (sGC), \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac Bayer Adempas (2013). \u0395\u03b3\u03ba\u03c1\u03af\u03b8\u03b7\u03ba\u03b5 \u03b3\u03b9\u03b1 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 (PAH, WHO \u039f\u03bc\u03ac\u03b4\u03b1 1) \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03bc\u03cc\u03bd\u03bf \u03c3\u03ba\u03b5\u03cd\u03b1\u03c3\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c4\u03cc\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03bc\u03b7 \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03b5\u03bc\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 (CTEPH, WHO \u039f\u03bc\u03ac\u03b4\u03b1 4). \u0391\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 PATENT-1 \u03ba\u03b1\u03b9 CHEST-1. \u0395\u03b9\u03b4\u03b9\u03ba\u03ac \u03b4\u03b9\u03b1\u03c7\u03b5\u03b9\u03c1\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b7 \u03c0\u03ac\u03b8\u03b7\u03c3\u03b7 \u2014 \u03cc\u03c7\u03b9 \u03c3\u03c5\u03bd\u03b7\u03b8\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7. \u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b1\u03bd\u03c4\u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7 \u03bc\u03b5 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 PDE5 \u03ba\u03b1\u03b9 \u03bd\u03b9\u03c4\u03c1\u03b9\u03ba\u03ac.<\/p>","protected":false},"featured_media":60438,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3260,3356],"product_tag":[4861,4862],"class_list":{"0":"post-60437","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-heart-blood-pressure","9":"product_cat-high-blood-pressure-medication","10":"product_tag-rioci","11":"product_tag-riociguat","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/60437","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=60437"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/60438"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=60437"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=60437"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=60437"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=60437"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}