<\/p>\n
Simlo 5<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03bc\u03ac\u03c1\u03ba\u03b1 simvastatin<\/strong> (5 mg), \u03ad\u03bd\u03b1 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 (\u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1\u03c2 HMG-CoA \u03b1\u03bd\u03b1\u03b3\u03c9\u03b3\u03ac\u03c3\u03b7\u03c2)<\/strong> \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 LDL (\u201c\u03ba\u03b1\u03ba\u03bf\u03cd\u201d) \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ce\u03bd \u03c3\u03c5\u03bc\u03b2\u03ac\u03bd\u03c4\u03c9\u03bd<\/strong> \u2014 \u03ad\u03bc\u03c6\u03c1\u03b1\u03b3\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03bc\u03c5\u03bf\u03ba\u03b1\u03c1\u03b4\u03af\u03bf\u03c5, \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03cc \u03b5\u03c0\u03b5\u03b9\u03c3\u03cc\u03b4\u03b9\u03bf \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc \u03b8\u03ac\u03bd\u03b1\u03c4\u03bf \u2014 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7 \u03ae \u03ba\u03b1\u03b8\u03b9\u03b5\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf. \u039f\u03b9 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03b1 \u03b9\u03c3\u03c7\u03c5\u03c1\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03b1\u03c0\u03cc \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2<\/strong> \u03bf\u03c0\u03bf\u03b9\u03b1\u03c3\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1\u03c2 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd \u03bc\u03b5\u03af\u03c9\u03c3\u03b7\u03c2 \u03bb\u03b9\u03c0\u03b9\u03b4\u03af\u03c9\u03bd: \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 22% \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c3\u03b5 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ac \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ac \u03c3\u03c5\u03bc\u03b2\u03ac\u03bd\u03c4\u03b1 \u03b1\u03bd\u03ac \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 LDL-C \u03ba\u03b1\u03c4\u03ac 1 mmol\/L (\u03bc\u03b5\u03c4\u03b1-\u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 CTT, >170,000 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2). \u039c\u03ad\u03c4\u03c1\u03b9\u03b1\u03c2 \u03ad\u03bd\u03c4\u03b1\u03c3\u03b7\u03c2<\/strong> at 20–40 mg\/day (lowers LDL-C by ~30–40%). The classic moderate-intensity statin. Has among the largest outcome-trial datasets (4S, HPS, A to Z, SEARCH) for cardiovascular event reduction. The catch is extensive CYP3A4 metabolism \u2014 more drug interactions than rosuvastatin or pitavastatin. Main side effects: muscle aches (5–10%, usually mild), mild transaminase elevation, small new-onset diabetes signal in at-risk patients. Rare but serious: rhabdomyolysis, immune-mediated necrotising myopathy. \u0391\u03c0\u03bf\u03c6\u03cd\u03b3\u03b5\u03c4\u03b5 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7\u03c2<\/strong> (category X). Evening or bedtime dosing matters<\/strong> \u2014 HMG-CoA reductase activity peaks overnight, so evening-dosed simvastatin gives about 10% greater LDL reduction than morning dosing.<\/p>\n<\/div>\n \ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n \u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n Simlo 5 is an oral lipid-lowering medicine containing simvastatin<\/strong> (5 mg), manufactured by Micro Labs. Supplied in packs of 30, 60, 90 or 180 tablets. Originator brand: Zocor (Merck, 1988).<\/p>\n simvastatin belongs to the \u03bf\u03bc\u03ac\u03b4\u03b1 \u03c4\u03c9\u03bd \u03c3\u03c4\u03b1\u03c4\u03b9\u03bd\u03ce\u03bd<\/strong> (\u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 HMG-CoA \u03b1\u03bd\u03b1\u03b3\u03c9\u03b3\u03ac\u03c3\u03b7\u03c2), \u03c4\u03b1 \u03c0\u03b9\u03bf \u03b5\u03c5\u03c1\u03ad\u03c9\u03c2 \u03c3\u03c5\u03bd\u03c4\u03b1\u03b3\u03bf\u03b3\u03c1\u03b1\u03c6\u03bf\u03cd\u03bc\u03b5\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03c3\u03c4\u03bf\u03bd \u03ba\u03cc\u03c3\u03bc\u03bf. \u039f\u03b9 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u039a\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf \u0392\u03b1\u03c3\u03b9\u03ba\u03ce\u03bd \u03a6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd \u03c4\u03bf\u03c5 WHO \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c0\u03c1\u03ce\u03c4\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2 \u03c3\u03c7\u03b5\u03b4\u03cc\u03bd \u03c3\u03b5 \u03ba\u03ac\u03b8\u03b5 \u03c3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b7 \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03b1 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ce\u03bd \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03c9\u03bd (ACC\/AHA, ESC\/EAS, NICE, CCS). \u039c\u03ad\u03c4\u03c1\u03b9\u03b1\u03c2 \u03ad\u03bd\u03c4\u03b1\u03c3\u03b7\u03c2<\/strong> at 20–40 mg\/day (lowers LDL-C by ~30–40%).<\/p>\n simvastatin is a competitive inhibitor of HMG-CoA \u03b1\u03bd\u03b1\u03b3\u03c9\u03b3\u03ac\u03c3\u03b7\u03c2<\/strong>, \u03c4\u03bf \u03c1\u03c5\u03b8\u03bc\u03bf\u03ba\u03b1\u03b8\u03bf\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf \u03c3\u03c4\u03b7 \u03b2\u03b9\u03bf\u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03c3\u03c4\u03bf \u03ae\u03c0\u03b1\u03c4\u03bf. \u039f \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b1\u03c5\u03c4\u03bf\u03cd \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b6\u03cd\u03bc\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03b5\u03c0\u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03b5\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2:<\/p>\n \u03a6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae:<\/strong> Extensively metabolised by CYP3A4<\/strong> \u2014 this drives most of its drug interactions. Half-life: 1.9 hours (simvastatin) \/ 4–7 hours (active acid metabolite). Evening or bedtime dosing matters<\/strong> \u2014 HMG-CoA reductase activity peaks overnight, so evening-dosed simvastatin gives about 10% greater LDL reduction than morning dosing.<\/p>\n \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7: \u0397 LDL-C \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 2 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03c9\u03bd, \u03c6\u03c4\u03ac\u03bd\u03b5\u03b9 \u03c3\u03c7\u03b5\u03b4\u03cc\u03bd \u03c3\u03c4\u03bf \u03bc\u03ad\u03b3\u03b9\u03c3\u03c4\u03bf \u03c3\u03b5 4\u20136 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2. \u0395\u03bb\u03ad\u03b3\u03be\u03c4\u03b5 \u03c4\u03bf \u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03ba\u03b1\u03b9 \u03c4\u03b1 ALT 6\u201312 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03ae \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03c4\u03b7\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2.<\/p>\n Start 10–20 mg once daily in the evening (bedtime). Typical maintenance: 20–40 mg\/day. Do not exceed 40 mg\/day<\/strong> in most patients \u2014 the 80 mg dose was restricted by the FDA in 2011 due to disproportionate myopathy and rhabdomyolysis risk.<\/p>\n \u039f\u03b9 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ac \u03ba\u03b1\u03bb\u03ac \u03b1\u03bd\u03b5\u03ba\u03c4\u03ad\u03c2. \u03a3\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b5\u03c2 \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2, \u03bf \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03c1\u03c5\u03b8\u03bc\u03cc\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bd\u03b5\u03c1\u03b3\u03b5\u03b9\u03ce\u03bd \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03bf\u03cd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03ba\u03c1\u03cc\u03c2.<\/p>\n \u03a3\u03c5\u03c7\u03bd\u03ad\u03c2:<\/strong><\/p>\n \u03a3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b1\u03bb\u03bb\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac:<\/strong><\/p>\n Avoid or dose-limit<\/strong> with: strong CYP3A4 inhibitors (itraconazole, ketoconazole, clarithromycin, erythromycin, HIV protease inhibitors, cobicistat) \u2014 contraindicated combinations. \u03a7\u03c5\u03bc\u03cc\u03c2 \u03b3\u03ba\u03c1\u03ad\u03b9\u03c0\u03c6\u03c1\u03bf\u03c5\u03c4<\/strong> \u2014 avoid, raises simvastatin levels several-fold. Amlodipine, amiodarone, diltiazem, verapamil, dronedarone, ranolazine<\/strong> \u2014 limit simvastatin to 20 mg\/day. \u0393\u03b5\u03bc\u03c6\u03b9\u03bc\u03c0\u03c1\u03bf\u03b6\u03af\u03bb\u03b7<\/strong> \u2014 contraindicated; severe myopathy risk. Fenofibrate, niacin ≥ 1 g\/day<\/strong> \u2014 use cautiously.<\/p>\n Store Simlo 5 below 25°C in a dry place, in the original blister. Keep out of reach of children.<\/p>\n Yes — Simlo 5 contains the active ingredient simvastatin. Bioequivalence to the originator brand (Zocor (Merck, 1988)) is required by regulatory authorities, so clinical effect is the same at the same dose.<\/p>\n For LDL-lowering potency: rosuvastatin > atorvastatin > simvastatin > pravastatin<\/strong>. Simvastatin 40 mg is roughly equivalent to atorvastatin 10 mg or rosuvastatin 5 mg. For patients needing > 40% LDL reduction (high-risk primary prevention or secondary prevention), atorvastatin 20–80 mg or rosuvastatin 10–40 mg is usually preferred over simvastatin. Simvastatin remains a reasonable low-cost choice in low-to-moderate risk patients without the interaction problems (not on CYP3A4 inhibitors, not on amlodipine\/amiodarone combinations).<\/p>\n Evening or bedtime dosing matters<\/strong> \u2014 HMG-CoA reductase activity peaks overnight, so evening-dosed simvastatin gives about 10% greater LDL reduction than morning dosing.<\/p>\n \u03a3\u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2, \u03bd\u03b1\u03b9. \u039f\u03b9 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd \u03bc\u03cc\u03bd\u03bf \u03cc\u03c3\u03bf \u03c4\u03b9\u03c2 \u03c0\u03b1\u03af\u03c1\u03bd\u03b5\u03c4\u03b5. \u0393\u03b9\u03b1 \u03b4\u03b5\u03c5\u03c4\u03b5\u03c1\u03bf\u03b3\u03b5\u03bd\u03ae \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 (\u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03b2\u03bf\u03bb\u03ae, \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03cc \u03b5\u03c0\u03b5\u03b9\u03c3\u03cc\u03b4\u03b9\u03bf, \u03c4\u03bf\u03c0\u03bf\u03b8\u03ad\u03c4\u03b7\u03c3\u03b7 \u03c3\u03c4\u03b5\u03bd\u03c4) \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03b3\u03b9\u03b1 \u03cc\u03bb\u03b7 \u03c4\u03b7 \u03b6\u03c9\u03ae. \u0393\u03b9\u03b1 \u03c0\u03c1\u03c9\u03c4\u03bf\u03b3\u03b5\u03bd\u03ae \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bc\u03b5\u03c1\u03b9\u03ba\u03ad\u03c2 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03bf\u03cd\u03bd \u03b5\u03ac\u03bd \u03bf\u03b9 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c3\u03c4\u03bf\u03bd \u03c4\u03c1\u03cc\u03c0\u03bf \u03b6\u03c9\u03ae\u03c2 \u03b5\u03c0\u03b9\u03c4\u03cd\u03c7\u03bf\u03c5\u03bd \u03bc\u03cc\u03bd\u03b9\u03bc\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 LDL \u03ba\u03b1\u03c4\u03ac 40\u201350% \u03ba\u03b1\u03b9 \u03c4\u03bf 10-\u03b5\u03c4\u03ad\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03c0\u03ad\u03c3\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac, \u03b1\u03bb\u03bb\u03ac \u03b7 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03bc\u03b5\u03c4\u03ac \u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c4\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 LDL \u03c0\u03af\u03c3\u03c9 \u03c3\u03c4\u03b1 \u03c0\u03c1\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b5\u03bd\u03c4\u03cc\u03c2 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03c9\u03bd.<\/p>\n \u03a0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 5\u201310% \u03c4\u03c9\u03bd \u03c7\u03c1\u03b7\u03c3\u03c4\u03ce\u03bd \u03c3\u03c4\u03b1\u03c4\u03b9\u03bd\u03ce\u03bd \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03bc\u03c5\u03ca\u03ba\u03bf\u03cd\u03c2 \u03c0\u03cc\u03bd\u03bf\u03c5\u03c2, \u03b1\u03bb\u03bb\u03ac \u03bf\u03b9 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 SAMSON (2020) \u03ba\u03b1\u03b9 StatinWISE (2021) \u2014 \u03ba\u03bf\u03bc\u03c8\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 N-of-1 \u03bc\u03b5 \u03c4\u03c5\u03c6\u03bb\u03ad\u03c2 \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7\u03c2\/\u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03bf\u03cd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u2014 \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03cc\u03c4\u03b9 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c4\u03bf 90% \u03c4\u03c9\u03bd \u03bc\u03c5\u03ca\u03ba\u03ce\u03bd \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b1\u03c0\u03bf\u03b4\u03af\u03b4\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03bd\u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03cc \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf (\u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03bf\u03c5\u03bd \u03b5\u03be\u03af\u03c3\u03bf\u03c5 \u03bc\u03b5 \u03c4\u03bf \u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03cc \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf). \u03a0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03bc\u03c5\u03b1\u03bb\u03b3\u03af\u03b1 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9\u00b7 \u03b5\u03ac\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b3\u03bd\u03ae\u03c3\u03b9\u03b1, \u03b7 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03c3\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7, \u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2 \u03ae \u03b7 \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03c3\u03c3\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b7\u03bc\u03b5\u03c1\u03ae\u03c3\u03b9\u03b1 \u03bb\u03ae\u03c8\u03b7 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03bb\u03cd\u03b5\u03b9. \u039c\u03b5\u03c4\u03c1\u03ae\u03c3\u03c4\u03b5 \u03c4\u03b7\u03bd CK \u03b5\u03ac\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae\u00b7 \u03b4\u03b9\u03b1\u03ba\u03cc\u03c8\u03c4\u03b5 \u03b1\u03bc\u03ad\u03c3\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03b6\u03b7\u03c4\u03ae\u03c3\u03c4\u03b5 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c0\u03b5\u03c1\u03af\u03b8\u03b1\u03bb\u03c8\u03b7 \u03b5\u03ac\u03bd \u03bf \u03bc\u03c5\u03ca\u03ba\u03cc\u03c2 \u03c0\u03cc\u03bd\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03bf\u03b2\u03b1\u03c1\u03cc\u03c2 \u03bc\u03b5 \u03c3\u03ba\u03bf\u03cd\u03c1\u03b1 \u03bf\u03cd\u03c1\u03b1 (\u03c1\u03b1\u03b2\u03b4\u03bf\u03bc\u03c5\u03cc\u03bb\u03c5\u03c3\u03b7).<\/p>\n \u039f\u03b9 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd\u03c4\u03bf\u03c2 CoQ10, \u03b1\u03bb\u03bb\u03ac \u03bf\u03b9 \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 CoQ10 (200 mg\/\u03b7\u03bc\u03ad\u03c1\u03b1) \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ac \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b1 \u03bc\u03c5\u03ca\u03ba\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2. \u0395\u03af\u03bd\u03b1\u03b9 \u03b1\u03c3\u03c6\u03b1\u03bb\u03ad\u03c2, \u03b1\u03bb\u03bb\u03ac \u03b7 \u03c6\u03b8\u03b7\u03bd\u03ae \u03c3\u03c5\u03bc\u03c0\u03bb\u03ae\u03c1\u03c9\u03c3\u03b7 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c5\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c4\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c3\u03c9\u03c3\u03c4\u03ae \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b5\u03c0\u03af\u03bc\u03bf\u03bd\u03bf\u03c5 \u03bc\u03c5\u03ca\u03ba\u03bf\u03cd \u03c0\u03cc\u03bd\u03bf\u03c5.<\/p>\n \u039c\u03ad\u03c4\u03c1\u03b9\u03b1 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03b1\u03bb\u03ba\u03bf\u03cc\u03bb (1\u20132 \u03bc\u03bf\u03bd\u03ac\u03b4\u03b5\u03c2\/\u03b7\u03bc\u03ad\u03c1\u03b1) \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bf\u03b4\u03b5\u03ba\u03c4\u03ae. \u0397 \u03b2\u03b1\u03c1\u03b9\u03ac \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b1\u03cd\u03be\u03b7\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03b5\u03bd\u03b6\u03cd\u03bc\u03c9\u03bd \u03c4\u03bf\u03c5 \u03ae\u03c0\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c6\u03b5\u03cd\u03b3\u03b5\u03c4\u03b1\u03b9. \u03a3\u03c5\u03b6\u03b7\u03c4\u03ae\u03c3\u03c4\u03b5 \u03b5\u03b9\u03bb\u03b9\u03ba\u03c1\u03b9\u03bd\u03ac \u03bc\u03b5 \u03c4\u03bf\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c3\u03b1\u03c2\u00b7 \u03c4\u03bf \u03b1\u03bb\u03ba\u03bf\u03cc\u03bb \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03ae\u03c0\u03b1\u03c4\u03bf\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7.<\/p>\n \u03a0\u03ac\u03c1\u03c4\u03b5 \u03c4\u03b7 \u03bc\u03cc\u03bb\u03b9\u03c2 \u03c4\u03bf \u03b8\u03c5\u03bc\u03b7\u03b8\u03b5\u03af\u03c4\u03b5. \u0395\u03ac\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03bf\u03bd\u03c4\u03ac \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b7 \u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03c3\u03b1\u03c2, \u03c0\u03b1\u03c1\u03b1\u03bb\u03b5\u03af\u03c8\u03c4\u03b5 \u03c4\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03c3\u03c4\u03b5 \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03ac \u2014 \u03bc\u03b7\u03bd \u03c0\u03ac\u03c1\u03b5\u03c4\u03b5 \u03b4\u03b9\u03c0\u03bb\u03ae \u03b4\u03cc\u03c3\u03b7.<\/p>\n You can order Simlo 5 (5 mg) from MedsBase in packs of 30, 60, 90 or 180 tablets. We ship worldwide with discreet packaging and genuine WHO-GMP certified manufacturer stock.<\/p>\n Simlo 5 is supplied through a WHO-GMP certified manufacturer with full COA documentation. We ship worldwide in plain, discreet packaging, and every order is covered by our \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/a>. \u039f \u03c4\u03af\u03c4\u03bb\u03bf\u03c2 \u03c7\u03c1\u03ad\u03c9\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7\u03bd \u03ba\u03ac\u03c1\u03c4\u03b1 \u03c3\u03b1\u03c2 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03b9 \u03c4\u03bf\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd (\u03ad\u03bd\u03b1\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1), \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5.<\/p>\n <\/p>\n \u0386\u03bb\u03bb\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 \u03c3\u03b5 \u03a7\u03c1\u03cc\u03bd\u03b9\u03b5\u03c2 \u03a0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2<\/strong> \u03c0\u03bf\u03c5 \u03bf\u03b9 \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2:<\/p>\n \u2705 Lowers cholesterol levels Simlo 5 contains Simvastatin.<\/p>","protected":false},"featured_media":60631,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3953],"product_tag":[4892,4675],"class_list":{"0":"post-60630","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-high-cholesterol-treatments","9":"product_tag-simlo","10":"product_tag-simvastatin","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/60630","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=60630"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/60631"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=60630"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=60630"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=60630"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=60630"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n
What Is Simlo 5?<\/h2>\n
What Is Simlo 5 Used For?<\/h2>\n
\n
How Does Simlo 5 Work?<\/h2>\n
\n
\u0394\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03a7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7<\/h2>\n
\n
\u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/h2>\n
\n
\n
\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03a6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd<\/h2>\n
Who Should Not Take Simlo 5?<\/h2>\n
\n
\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7<\/h2>\n
\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n
Is Simlo 5 the same as simvastatin?<\/h3>\n
Is simvastatin as good as atorvastatin or rosuvastatin?<\/h3>\n
When should I take Simlo 5 — morning or evening?<\/h3>\n
Do I need to take Simlo 5 for life?<\/h3>\n
\u03a4\u03b9 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03bc\u03c5\u03ca\u03ba\u03bf\u03cd\u03c2 \u03c0\u03cc\u03bd\u03bf\u03c5\u03c2;<\/h3>\n
Should I take CoQ10 with Simlo 5?<\/h3>\n
Can I drink alcohol on Simlo 5?<\/h3>\n
What if I forget to take Simlo 5?<\/h3>\n
Where can I buy Simlo 5 online?<\/h3>\n
\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03a6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03a7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03af\u03bd\u03b7<\/h2>\n
\n
\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n
\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2<\/h3>\n
\n
\n\u2705 \u039c\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5
\n\u2705 Improves lipid profile
\n\u2705 Prevents cardiovascular events
\n\u2705 Increases HDL cholesterol<\/p>\n