{"id":61116,"date":"2024-02-28T07:25:37","date_gmt":"2024-02-28T07:25:37","guid":{"rendered":"https:\/\/medsname.com\/champix\/"},"modified":"2026-05-01T10:49:16","modified_gmt":"2026-05-01T10:49:16","slug":"champix","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/champix\/","title":{"rendered":"Champix"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; Champix &mdash; varenicline 1 mg for smoking cessation<\/h3>\n<p style=\"margin:0;\">Champix is varenicline 1 mg, an &alpha;4&beta;2 nicotinic-acetylcholine partial agonist that reduces nicotine cravings and the rewarding effect of smoking. Set a quit date 8&ndash;14 days into a 12-week course; titrate from 0.5&nbsp;mg once daily up to 1&nbsp;mg twice daily. Most effective when combined with behavioural support; the 2016 EAGLES trial removed the historical neuropsychiatric black-box.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong> \u03a0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2 WHO-GMP \u00b7 \u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u00b7 \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u00b7 1,400+ \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 <a href=\"https:\/\/medsbase.com\/el\/reviews\/\">\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\"><strong>\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n<h3>\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n<p>\u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n<h2 class=\"wp-block-heading\">What is Champix?<\/h2>\n<p>Champix is a smoking-cessation aid containing <strong>varenicline 1 mg<\/strong> (film-coated tablets), supplied by Pfizer. It is a selective partial agonist at the &alpha;4&beta;2 subtype of the neuronal nicotinic acetylcholine receptor &mdash; the same receptor nicotine binds &mdash; and is one of the most effective monotherapies for tobacco dependence, with cessation rates roughly two to three times those of placebo and consistently superior to single-agent nicotine-replacement therapy in head-to-head trials.<\/p>\n<h2 class=\"wp-block-heading\">How varenicline works<\/h2>\n<p>Varenicline binds the &alpha;4&beta;2 nicotinic receptor with both <strong>agonist and antagonist<\/strong> properties: as a partial agonist it produces about 30&ndash;60% of nicotine&#8217;s dopamine release, dampening cravings and withdrawal; as an antagonist it occupies the receptor and blocks the dopaminergic surge from any cigarette smoked while on therapy, so a cigarette during the course feels much less rewarding than usual. This dual action distinguishes it from bupropion (an atypical antidepressant with weak nicotinic antagonism) and from nicotine-replacement therapy (full agonism only).<\/p>\n<h2 class=\"wp-block-heading\">How Champix is used<\/h2>\n<p>The standard adult course is <strong>12 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2<\/strong>. Set a quit date 8&ndash;14 days into the course &mdash; do not stop smoking on day 1. An alternative &#8220;flexible quit&#8221; approach lets the smoker reduce gradually over the first 12 weeks and quit any time before the end.<\/p>\n<table style=\"width:100%;border-collapse:collapse;margin:12px 0;font-size:13.5px;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;\">Days<\/th>\n<th style=\"padding:8px;text-align:left;\">\u0394\u03cc\u03c3\u03b7<\/th>\n<th style=\"padding:8px;text-align:left;\">\u03a3\u03b7\u03bc\u03b5\u03b9\u03ce\u03c3\u03b5\u03b9\u03c2<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;\">Days 1&ndash;3<\/td>\n<td style=\"padding:8px;\">0.5&nbsp;mg once daily<\/td>\n<td style=\"padding:8px;\">After breakfast<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;\">Days 4&ndash;7<\/td>\n<td style=\"padding:8px;\">0.5&nbsp;mg twice daily<\/td>\n<td style=\"padding:8px;\">12 hours apart<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;\">Day 8 onwards (week 2&ndash;12)<\/td>\n<td style=\"padding:8px;\"><strong>1&nbsp;mg twice daily<\/strong><\/td>\n<td style=\"padding:8px;\">Maintenance; quit date in this window<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;\">Optional 12-week extension<\/td>\n<td style=\"padding:8px;\">1&nbsp;mg twice daily<\/td>\n<td style=\"padding:8px;\">For those who quit successfully &mdash; doubles 1-year abstinence rates<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Take with a full glass of water after a meal<\/strong> &mdash; nausea is the most common reason for discontinuation and is reduced by food and adequate hydration. If 1&nbsp;mg twice daily is not tolerated, dropping back to 0.5&nbsp;mg twice daily is acceptable and still active.<\/p>\n<h2 class=\"wp-block-heading\">\u03a0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03b4\u03cc\u03c3\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1<\/h2>\n<p>Varenicline is excreted ~92% unchanged in urine. Dose adjustment is required in significant renal impairment:<\/p>\n<table style=\"width:100%;border-collapse:collapse;margin:12px 0;font-size:13.5px;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;\">eGFR (mL\/min\/1.73 m\u00b2)<\/th>\n<th style=\"padding:8px;text-align:left;\">\u039c\u03ad\u03b3\u03b9\u03c3\u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;\">&ge; 30 (mild&ndash;moderate impairment)<\/td>\n<td style=\"padding:8px;\">Standard 1&nbsp;mg BID<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;\">&lt; 30 (severe impairment)<\/td>\n<td style=\"padding:8px;\">1&nbsp;mg once daily (titrate from 0.5&nbsp;mg daily)<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;\">\u0391\u03b9\u03bc\u03bf\u03ba\u03ac\u03b8\u03b1\u03c1\u03c3\u03b7<\/td>\n<td style=\"padding:8px;\">0.5&nbsp;mg once daily, may titrate to 1&nbsp;mg once daily<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 22px 0;border-radius:4px;font-size:14px;\"><strong>Neuropsychiatric history.<\/strong> The original FDA black-box warning (2009) was <strong>removed in 2016<\/strong> after the EAGLES trial (8,144 randomised smokers, including a stable-psychiatric cohort) found no statistically significant excess of clinically significant neuropsychiatric events versus placebo, NRT, or bupropion. However, smoking cessation itself can unmask underlying mood symptoms; patients with serious mental illness should still be monitored for new or worsening depression, anxiety, agitation, or suicidal ideation, especially in the first 4 weeks. Stop and contact a clinician if these emerge.<\/div>\n<h2 class=\"wp-block-heading\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/h2>\n<ul>\n<li><strong>\u039d\u03b1\u03c5\u03c4\u03af\u03b1<\/strong> (~30%, usually mild&ndash;moderate, abates within 2&ndash;3 weeks; take with food and water)<\/li>\n<li><strong>Vivid or abnormal dreams<\/strong> (~13%, often fade after week 4)<\/li>\n<li>Insomnia, headache, dyspepsia, dry mouth<\/li>\n<li>Constipation, flatulence, taste disturbance<\/li>\n<li>Fatigue or somnolence (caution with driving until tolerance established)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd<\/h2>\n<p>Varenicline has a remarkably clean interaction profile because it is renally cleared and does not significantly inhibit or induce CYP enzymes. Notable points:<\/p>\n<ul>\n<li><strong>Nicotine-replacement therapy (NRT):<\/strong> combination is sometimes used in heavy smokers but increases nausea and headache &mdash; weigh benefit case-by-case.<\/li>\n<li><strong>\u0397 Cimetidine<\/strong> reduces varenicline renal clearance ~29%; reduce dose in concurrent severe renal impairment.<\/li>\n<li><strong>Alcohol:<\/strong> case reports of altered intoxication or aggression on varenicline &mdash; counsel patients to use alcohol cautiously, especially while titrating.<\/li>\n<li><strong>\u0392\u03b1\u03c1\u03c6\u03b1\u03c1\u03af\u03bd\u03b7:<\/strong> smoking cessation itself raises INR (cigarette smoke induces CYP1A2, accelerating warfarin metabolism); monitor INR more closely after quitting, regardless of varenicline.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u0391\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03af \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03bf\u03af<\/h2>\n<ul>\n<li>Hypersensitivity to varenicline.<\/li>\n<li><strong>\u0395\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7:<\/strong> avoid &mdash; limited human safety data; counsel cessation via behavioural support and NRT preferentially.<\/li>\n<li><strong>\u0398\u03b7\u03bb\u03b1\u03c3\u03bc\u03cc\u03c2:<\/strong> avoid; small amounts excreted in breast milk in animal studies, no human data.<\/li>\n<li><strong>Severe renal impairment:<\/strong> dose-reduce as above.<\/li>\n<li>Cardiovascular disease: a small numerical excess of cardiovascular events in stable cardiovascular patients was seen in the original Pfizer trial; subsequent meta-analyses have not confirmed a causal link, and current guidelines support use after weighing the much larger cardiovascular harm of continued smoking.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Combine with behavioural support<\/h2>\n<p>Pharmacotherapy alone roughly doubles quit rates over willpower; pharmacotherapy <strong>\u03c3\u03c5\u03bd<\/strong> structured behavioural support (text-message programmes, group counselling, telephone quit-lines, app-based CBT) roughly triples them. Even brief structured advice from a clinician at the start of therapy meaningfully raises 1-year abstinence.<\/p>\n<h2 class=\"wp-block-heading\">\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7<\/h2>\n<p>\u0391\u03c0\u03bf\u03b8\u03b7\u03ba\u03b5\u03cd\u03c3\u03c4\u03b5 \u03c3\u03b5 \u03b8\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03af\u03b1 \u03b4\u03c9\u03bc\u03b1\u03c4\u03af\u03bf\u03c5 (15\u201330 \u00b0C \/ 59\u201386 \u00b0F), \u03c3\u03c4\u03b7\u03bd \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1, \u03bc\u03b1\u03ba\u03c1\u03b9\u03ac \u03b1\u03c0\u03cc \u03ac\u03bc\u03b5\u03c3\u03bf \u03c6\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03c5\u03b3\u03c1\u03b1\u03c3\u03af\u03b1. \u039a\u03c1\u03b1\u03c4\u03ae\u03c3\u03c4\u03b5 \u03bc\u03b1\u03ba\u03c1\u03b9\u03ac \u03b1\u03c0\u03cc \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac.<\/p>\n<h2 id=\"faqs\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3 class=\"wp-block-heading\">When does varenicline start working?<\/h3>\n<p>Receptor effects begin within hours of the first dose, but the clinically relevant craving reduction usually emerges by the second week as titration reaches the full 1&nbsp;mg twice-daily dose. Setting a quit date 8&ndash;14 days into the course allows that effect to be present at the moment cessation is attempted.<\/p>\n<h3 class=\"wp-block-heading\">Why is the quit date not on day 1?<\/h3>\n<p>Day 1 is too early &mdash; receptor occupancy is partial at the 0.5&nbsp;mg starting dose. Quitting at 8&ndash;14 days hits the curve at full antagonist coverage, when a cigarette smoked is much less rewarding and craving suppression is strongest.<\/p>\n<h3 class=\"wp-block-heading\">Is varenicline more effective than nicotine patches?<\/h3>\n<p>Direct head-to-head trials (notably EAGLES, 2016) showed varenicline produced significantly higher 9&ndash;12 week and 6-month abstinence rates than the nicotine patch alone, NRT plus bupropion combinations narrow the gap. Combination NRT (patch + lozenge) may match varenicline in some studies. The best therapy is the one the patient will use consistently for 12 weeks.<\/p>\n<h3 class=\"wp-block-heading\">What if I have one cigarette while on varenicline?<\/h3>\n<p>It is a setback, not a failure. Most smokers slip at least once during a quit attempt. The cigarette will feel notably less satisfying because of varenicline&#8217;s receptor blockade &mdash; this is mechanistic, not motivational. Continue the medication and re-engage your behavioural plan; a single slip does not predict relapse.<\/p>\n<h3 class=\"wp-block-heading\">\u03a0\u03cc\u03c3\u03bf \u03ba\u03b1\u03b9\u03c1\u03cc \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c4\u03bf \u03c0\u03b1\u03af\u03c1\u03bd\u03c9;<\/h3>\n<p>The licensed course is 12 weeks. Smokers who have successfully quit and complete a second 12-week extension (24 weeks total) have roughly double the 1-year abstinence rate of those who stop at week 12. Discuss extension with your prescriber.<\/p>\n<h3 class=\"wp-block-heading\">Can I take it with bupropion?<\/h3>\n<p>Combination is sometimes used in highly dependent smokers who fail monotherapy, particularly with comorbid depression, but the evidence base is thinner and adverse-event rates rise. This is a specialist decision rather than a routine option.<\/p>\n<h3 class=\"wp-block-heading\">Is the neuropsychiatric warning still on the label?<\/h3>\n<p>No &mdash; the FDA removed the boxed warning in December 2016 after the EAGLES trial, the largest randomised cessation trial ever conducted, found no significant excess of serious neuropsychiatric events. Routine clinical monitoring for mood change remains sensible because cessation itself unmasks symptoms in vulnerable patients.<\/p>\n<h3 class=\"wp-block-heading\">Will it interfere with alcohol?<\/h3>\n<p>A small number of post-marketing reports describe altered intoxication or out-of-character aggression while drinking on varenicline. Use alcohol cautiously, especially during titration, and consider avoiding it if you are escalating to the full 1&nbsp;mg twice-daily dose.<\/p>\n<h3 class=\"wp-block-heading\">Does it cause weight gain?<\/h3>\n<p>Some weight gain is typical after quitting smoking regardless of cessation method (~3&ndash;5&nbsp;kg average). Varenicline does not directly cause weight gain and may slightly attenuate it compared with placebo by reducing appetite-driven post-quit eating in some patients.<\/p>\n<h3 class=\"wp-block-heading\">Can I drive while on it?<\/h3>\n<p>Yes, but be cautious until you know how it affects you &mdash; somnolence, dizziness, and abnormal dreams that disrupt sleep can all impair concentration. If you experience these, avoid driving and discuss with your prescriber.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0 0 0;border-radius:4px;font-size:13.5px;line-height:1.55;\"><strong>\u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03b5\u03c5\u03b8\u03cd\u03bd\u03b7\u03c2:<\/strong> \u0391\u03c5\u03c4\u03ad\u03c2 \u03bf\u03b9 \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b5\u03c2 \u03b1\u03c0\u03b5\u03c5\u03b8\u03cd\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2 \u03c5\u03c0\u03cc \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b2\u03bb\u03b5\u03c8\u03b7. \u039f\u03b9 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03c7\u03c1\u03ae\u03c3\u03b7\u03c2 \u03bf\u03c5\u03c3\u03b9\u03ce\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd\u03c0\u03bb\u03bf\u03ba\u03b5\u03c2 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b5\u03c2 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2 \u2014 \u03b7 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03ad\u03bd\u03b1 \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03bf \u03c4\u03b7\u03c2 \u03c6\u03c1\u03bf\u03bd\u03c4\u03af\u03b4\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae, \u03c5\u03c0\u03bf\u03c3\u03c4\u03ae\u03c1\u03b9\u03be\u03b7 \u03b1\u03c0\u03cc \u03bf\u03bc\u03bf\u03c4\u03af\u03bc\u03bf\u03c5\u03c2 (AA, SMART Recovery, NA, \u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03b1\u03bc\u03bf\u03b9\u03b2\u03b1\u03af\u03b1\u03c2 \u03b2\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1\u03c2), \u03c4\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c7\u03b5\u03af\u03c1\u03b9\u03c3\u03b7 \u03c3\u03c5\u03bd\u03bf\u03b4\u03ce\u03bd \u03c8\u03c5\u03c7\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03c9\u03bd (\u03ba\u03b1\u03c4\u03ac\u03b8\u03bb\u03b9\u03c8\u03b7, \u03ac\u03b3\u03c7\u03bf\u03c2, PTSD, ADHD). \u0397 \u03bf\u03be\u03b5\u03af\u03b1 \u03b1\u03c0\u03bf\u03c7\u03ae \u03b1\u03c0\u03cc \u03c4\u03bf \u03b1\u03bb\u03ba\u03bf\u03cc\u03bb \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03b5\u03b9 \u03c3\u03c0\u03b1\u03c3\u03bc\u03bf\u03cd\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03ad\u03bc\u03bf\u03c5\u03bb\u03b1 \u03b1\u03c0\u03cc\u03c6\u03c1\u03b1\u03be\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03ad\u03ba\u03c4\u03b1\u03ba\u03c4\u03b7 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u2014 \u03bc\u03b7\u03bd \u03be\u03b5\u03ba\u03b9\u03bd\u03ac\u03c4\u03b5 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c3\u03c5\u03bd\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03bf\u03be\u03b5\u03af\u03b1\u03c2 \u03b1\u03c0\u03cc\u03c3\u03c5\u03c1\u03c3\u03b7\u03c2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03c0\u03bf\u03c0\u03c4\u03b5\u03c5\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b1\u03c0\u03bf\u03c4\u03bf\u03be\u03af\u03bd\u03c9\u03c3\u03b7. \u03a3\u03c5\u03b6\u03b7\u03c4\u03ae\u03c3\u03c4\u03b5 \u03bf\u03c0\u03bf\u03b9\u03b1\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae\u03c2, \u03bc\u03b5 \u03ad\u03bd\u03b1\u03bd \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03bf \u03b9\u03b1\u03c4\u03c1\u03cc. \u0395\u03ac\u03bd \u03b5\u03c3\u03b5\u03af\u03c2 \u03ae \u03ba\u03ac\u03c0\u03bf\u03b9\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03c4\u03b5 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ba\u03c1\u03af\u03c3\u03b7, \u03b5\u03c0\u03b9\u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03ae\u03c3\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03c4\u03bf\u03c0\u03b9\u03ba\u03ad\u03c2 \u03c5\u03c0\u03b7\u03c1\u03b5\u03c3\u03af\u03b5\u03c2 \u03ad\u03ba\u03c4\u03b1\u03ba\u03c4\u03b7\u03c2 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7\u03c2 \u03ae \u03bc\u03b9\u03b1 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae \u03b2\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1\u03c2 (\u03c0.\u03c7. SAMHSA 1-800-662-HELP \u03c3\u03c4\u03b9\u03c2 \u0397\u03a0\u0391, Frank 0300 123 6600 \u03c3\u03c4\u03bf \u0397\u03bd\u03c9\u03bc\u03ad\u03bd\u03bf \u0392\u03b1\u03c3\u03af\u03bb\u03b5\u03b9\u03bf).<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2<\/h3>\n<p>\u0386\u03bb\u03bb\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 \u03c3\u03b5 <strong>\u0393\u03b5\u03bd\u03b9\u03ba\u03ae \u03a5\u03b3\u03b5\u03af\u03b1<\/strong> \u03c0\u03bf\u03c5 \u03bf\u03b9 \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/moxicip\/\">Moxicip<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/distaclor-dt\/\">Distaclor Dt<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/nexpro\/\">\u039d\u03ad\u03be\u03c0\u03c1\u03bf<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/ivrea-cream\/\">Ivrea Cream<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/grisoheal\/\">Grisoheal<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Reduces nicotine cravings<br \/>\n\u2705 Helps quit smoking<br \/>\n\u2705 Decreases withdrawal symptoms<br \/>\n\u2705 Increases quitting success<br \/>\n\u2705 Improves long-term abstinence<\/p>\n<p>Champix contains Varenicline.<\/p>","protected":false},"featured_media":61117,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3461,3141,3342],"product_tag":[4980,4981],"class_list":{"0":"post-61116","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-alcohol-and-drug-treatment","7":"product_cat-category-overview","8":"product_cat-general-health","9":"product_tag-champix","10":"product_tag-varenicline","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/61116","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=61116"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/61117"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=61116"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=61116"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=61116"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=61116"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}