{"id":61588,"date":"2024-03-03T05:46:41","date_gmt":"2024-03-03T05:46:41","guid":{"rendered":"https:\/\/medsname.com\/atorvatin\/"},"modified":"2026-05-01T10:49:17","modified_gmt":"2026-05-01T10:49:17","slug":"atorvatin","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/atorvatin\/","title":{"rendered":"Atorvatin"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 \u0393\u03c1\u03ae\u03b3\u03bf\u03c1\u03b7 \u0391\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u2014 \u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf Atorvatin;<\/h3>\n<p style=\"margin:0;\"><strong>Atorvatin<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 <strong>\u03a4\u03b1\u03bc\u03c0\u03bb\u03ad\u03c4\u03b1 \u03b1\u03c4\u03bf\u03c1\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7\u03c2 5 mg<\/strong> \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd WHO-GMP \u2014 \u03ad\u03bd\u03b1\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1\u03c2 HMG-CoA \u03b1\u03bd\u03b1\u03b3\u03c9\u03b3\u03ac\u03c3\u03b7\u03c2 (\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7) \u03c5\u03c8\u03b7\u03bb\u03ae\u03c2 \u03ad\u03bd\u03c4\u03b1\u03c3\u03b7\u03c2, \u03bb\u03b9\u03c0\u03bf\u03c6\u03b9\u03bb\u03b9\u03ba\u03cc\u03c2. \u039f\u03b9 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03b1 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ac \u03c3\u03c5\u03bc\u03b2\u03ac\u03bd\u03c4\u03b1 \u03bc\u03b5 <strong>20-30% \u03b1\u03bd\u03ac mmol\/L \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 LDL-\u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2<\/strong> \u03c3\u03b5 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03bf\u03cd\u03c2 \u03c0\u03c1\u03c9\u03c4\u03bf\u03b3\u03b5\u03bd\u03bf\u03cd\u03c2 \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7\u03c2, \u03b4\u03b5\u03c5\u03c4\u03b5\u03c1\u03bf\u03b3\u03b5\u03bd\u03bf\u03cd\u03c2 \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7\u03c2, \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03cc. \u0397 \u03b1\u03c4\u03bf\u03c1\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 \u03b5\u03b9\u03c3\u03ae\u03c7\u03b8\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7 Parke-Davis\/Pfizer \u03c4\u03bf 1996 \u03c9\u03c2 <strong>Lipitor<\/strong> \u2014 \u03c4\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c0\u03c9\u03bb\u03ae\u03c3\u03b5\u03b9\u03c2 \u03cc\u03bb\u03c9\u03bd \u03c4\u03c9\u03bd \u03b5\u03c0\u03bf\u03c7\u03ce\u03bd \u03c3\u03c4\u03b7\u03bd \u03b1\u03ba\u03bc\u03ae \u03c4\u03bf\u03c5 ($12.5 \u03b4\u03b9\u03c3\u03b5\u03ba\u03b1\u03c4\u03bf\u03bc\u03bc\u03cd\u03c1\u03b9\u03b1\/\u03ad\u03c4\u03bf\u03c2 \u03c4\u03bf 2006). \u039b\u03b9\u03c0\u03cc\u03c6\u03b9\u03bb\u03bf \u03c3\u03c4\u03b1\u03c4\u03af\u03bd, \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ac \u03bc\u03ad\u03c3\u03c9 CYP3A4. \u0395\u03cd\u03c1\u03bf\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2 10-80 mg \u03bc\u03af\u03b1 \u03c6\u03bf\u03c1\u03ac \u03b7\u03bc\u03b5\u03c1\u03b7\u03c3\u03af\u03c9\u03c2\u00b7 40-80 mg \u03b5\u03af\u03bd\u03b1\u03b9 \u03c5\u03c8\u03b7\u03bb\u03ae\u03c2 \u03ad\u03bd\u03c4\u03b1\u03c3\u03b7\u03c2 \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03bb\u03b9\u03c0\u03b9\u03b4\u03af\u03c9\u03bd AHA\/ACC 2018. \u0399\u03c3\u03c7\u03cd\u03c2: \u03b7 \u03b1\u03c4\u03bf\u03c1\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 40 mg \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c4\u03bf LDL-C \u03ba\u03b1\u03c4\u03ac 50%\u00b7 80 mg \u03ba\u03b1\u03c4\u03ac 55%. \u03a4\u03c5\u03c0\u03b9\u03ba\u03ae \u03b4\u03cc\u03c3\u03b7: \u03bc\u03af\u03b1 \u03c6\u03bf\u03c1\u03ac \u03b7\u03bc\u03b5\u03c1\u03b7\u03c3\u03af\u03c9\u03c2, \u03b2\u03c1\u03ac\u03b4\u03c5 (\u03b3\u03b9\u03b1 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd \u03bc\u03b5 \u03c3\u03cd\u03bd\u03c4\u03bf\u03bc\u03bf \u03c7\u03c1\u03cc\u03bd\u03bf \u03b7\u03bc\u03b9\u03b6\u03c9\u03ae\u03c2) \u03ae \u03bf\u03c0\u03bf\u03b9\u03b1\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03ce\u03c1\u03b1 \u03b3\u03b9\u03b1 \u03b1\u03c4\u03bf\u03c1\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 (\u03bf \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b7\u03bc\u03b9\u03b6\u03c9\u03ae\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03ba\u03b5\u03c4\u03ac \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf\u03c2 \u03ce\u03c3\u03c4\u03b5 \u03bf \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03bb\u03ae\u03c8\u03b7\u03c2 \u03bd\u03b1 \u03bc\u03b7\u03bd \u03ad\u03c7\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1). \u039a\u03cd\u03c1\u03b9\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2: \u03bc\u03c5\u03ca\u03ba\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 (0.1-1% \u03bc\u03b5 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 CK\u00b7 \u03ad\u03c9\u03c2 10% nocebo \u03bc\u03c5\u03ca\u03ba\u03ad\u03c2 \u03b5\u03bd\u03bf\u03c7\u03bb\u03ae\u03c3\u03b5\u03b9\u03c2), \u03ae\u03c0\u03b9\u03b1 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03c1\u03b1\u03bd\u03c3\u03b1\u03bc\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 (3%), \u03bd\u03b5\u03b1\u03c1\u03cc\u03c2 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7\u03c2 \u03c3\u03b5 \u03b5\u03c5\u03ac\u03bb\u03c9\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 (~0.2 \u03b1\u03bd\u03ac 100 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae-\u03ad\u03c4\u03b7). \u0391\u03c0\u03bf\u03bb\u03cd\u03c4\u03c9\u03c2 \u03b1\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7, \u03b5\u03bd\u03b5\u03c1\u03b3\u03ae \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf, \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03c1\u03b1\u03b2\u03b4\u03bf\u03bc\u03c5\u03cc\u03bb\u03c5\u03c3\u03b7\u03c2.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong> \u03a0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2 WHO-GMP \u00b7 \u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u00b7 \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u00b7 1,400+ \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 <a href=\"https:\/\/medsbase.com\/el\/reviews\/\">\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\"><strong>\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n<h3>\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n<p>\u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n<h2 class=\"wp-block-heading\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf Atorvatin;<\/h2>\n<p>\u03a4\u03bf Atorvatin \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b4\u03b9\u03c3\u03ba\u03af\u03bf \u03b1\u03c4\u03bf\u03c1\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7\u03c2 5 mg \u03b3\u03b9\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd WHO-GMP, \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b5\u03c2 30-180 \u03b4\u03b9\u03c3\u03ba\u03af\u03c9\u03bd. \u0397 \u03b1\u03c4\u03bf\u03c1\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 \u03b5\u03b9\u03c3\u03ae\u03c7\u03b8\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd Parke-Davis\/Pfizer \u03c4\u03bf 1996 \u03c9\u03c2 <strong>Lipitor<\/strong> \u2014 \u03c4\u03bf \u03c0\u03b9\u03bf \u03b5\u03bc\u03c0\u03bf\u03c1\u03b9\u03ba\u03cc \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03cc\u03bb\u03c9\u03bd \u03c4\u03c9\u03bd \u03b5\u03c0\u03bf\u03c7\u03ce\u03bd \u03c3\u03c4\u03b7\u03bd \u03b1\u03ba\u03bc\u03ae \u03c4\u03bf\u03c5 (12,5 \u03b4\u03b9\u03c3\u03b5\u03ba\u03b1\u03c4\u03bf\u03bc\u03bc\u03cd\u03c1\u03b9\u03b1 \u03b4\u03bf\u03bb\u03ac\u03c1\u03b9\u03b1\/\u03ad\u03c4\u03bf\u03c2 \u03c4\u03bf 2006). \u039b\u03b9\u03c0\u03bf\u03c6\u03b9\u03bb\u03b9\u03ba\u03ae \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7, \u03b1\u03c0\u03bf\u03bc\u03b1\u03ba\u03c1\u03cd\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ac \u03bc\u03ad\u03c3\u03c9 CYP3A4. \u0395\u03cd\u03c1\u03bf\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2 10-80 mg \u03bc\u03af\u03b1 \u03c6\u03bf\u03c1\u03ac \u03b7\u03bc\u03b5\u03c1\u03b7\u03c3\u03af\u03c9\u03c2\u00b7 \u03bf\u03b9 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 40-80 mg \u03b8\u03b5\u03c9\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c5\u03c8\u03b7\u03bb\u03ae\u03c2 \u03ad\u03bd\u03c4\u03b1\u03c3\u03b7\u03c2 \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03bb\u03b9\u03c0\u03b9\u03b4\u03af\u03c9\u03bd AHA\/ACC 2018.<\/p>\n<h2 class=\"wp-block-heading\">\u03a0\u03ce\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03b7 \u03b1\u03c4\u03bf\u03c1\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7<\/h2>\n<p>\u0397 \u03b1\u03c4\u03bf\u03c1\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 <strong>HMG-CoA \u03b1\u03bd\u03b1\u03b3\u03c9\u03b3\u03ac\u03c3\u03b7\u03c2<\/strong>, \u03c4\u03bf \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf \u03c4\u03b7\u03c2 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b2\u03b9\u03bf\u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7\u03c2 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2. \u039a\u03b1\u03c4\u03ac \u03c3\u03c5\u03bd\u03ad\u03c0\u03b5\u03b9\u03b1:<\/p>\n<ul>\n<li><strong>\u039c\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7 \u03c3\u03b5 \u03b7\u03c0\u03b1\u03c4\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1<\/strong> \u2014 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2-\u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03bf\u03c5 (SREBP) \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd LDL \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03b7\u03c0\u03b1\u03c4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd<\/li>\n<li><strong>\u0391\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03ba\u03ac\u03b8\u03b1\u03c1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03bf\u03cd\u03c3\u03b1\u03c2 LDL-C<\/strong> \u2014 \u03bf \u03ba\u03cd\u03c1\u03b9\u03bf\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 LDL<\/li>\n<li><strong>\u039c\u03ad\u03c4\u03c1\u03b9\u03b1 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c4\u03c1\u03b9\u03b3\u03bb\u03c5\u03ba\u03b5\u03c1\u03b9\u03b4\u03af\u03c9\u03bd<\/strong> (10-20%) \u03ba\u03b1\u03b9 \u03bc\u03ad\u03c4\u03c1\u03b9\u03b1 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 HDL (5-10%)<\/li>\n<li><strong>\u03a0\u03bb\u03b5\u03b9\u03cc\u03c4\u03c1\u03bf\u03c0\u03b5\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2<\/strong> \u03c0\u03ad\u03c1\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 LDL \u2014 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae (\u03c0\u03c4\u03ce\u03c3\u03b7 hs-CRP), \u03b2\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b5\u03bd\u03b4\u03bf\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1, \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c0\u03bb\u03ac\u03ba\u03b1\u03c2, \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c0\u03bb\u03b1\u03c4\u03c3\u03b5\u03c4\u03c9\u03b4\u03ae\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1. \u03a4\u03bf \u03bc\u03ad\u03b3\u03b5\u03b8\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c9\u03c6\u03ad\u03bb\u03b5\u03b9\u03b1\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03b1\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03b5\u03be\u03b7\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5 LDL-C.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u0394\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 Atorvatin<\/h2>\n<p><strong>\u03a0\u03c1\u03c9\u03c4\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 (\u03c7\u03c9\u03c1\u03af\u03c2 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc \u03c3\u03c5\u03bc\u03b2\u03ac\u03bd):<\/strong> \u03be\u03b5\u03ba\u03b9\u03bd\u03ae\u03c3\u03c4\u03b5 \u03bc\u03b5 10-20 mg \u03bc\u03b9\u03b1 \u03c6\u03bf\u03c1\u03ac \u03c4\u03b7\u03bd \u03b7\u03bc\u03ad\u03c1\u03b1\u00b7 \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03cc\u03c3\u03c4\u03b5 \u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf ASCVD \u03b3\u03b9\u03b1 10 \u03ad\u03c4\u03b7. \u0393\u03b9\u03b1 \u03b4\u03b9\u03b1\u03b2\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03ae \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf ASCVD &gt;7,5%, \u03b7 \u03bc\u03ad\u03c4\u03c1\u03b9\u03b1 \u03ad\u03bd\u03c4\u03b1\u03c3\u03b7 (20-40 mg) \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03c5\u03c0\u03b9\u03ba\u03ae.<\/p>\n<p><strong>\u0394\u03b5\u03c5\u03c4\u03b5\u03c1\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 (\u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf \u03ad\u03bc\u03c6\u03c1\u03b1\u03b3\u03bc\u03b1, \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03cc \u03b5\u03c0\u03b5\u03b9\u03c3\u03cc\u03b4\u03b9\u03bf, \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ae \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf \u03ae \u03b4\u03b9\u03b1\u03b2\u03b7\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf):<\/strong> \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c5\u03c8\u03b7\u03bb\u03ae\u03c2 \u03ad\u03bd\u03c4\u03b1\u03c3\u03b7\u03c2 \u2014 40-80 mg \u03bc\u03b9\u03b1 \u03c6\u03bf\u03c1\u03ac \u03c4\u03b7\u03bd \u03b7\u03bc\u03ad\u03c1\u03b1. \u03a3\u03c4\u03cc\u03c7\u03bf\u03c2 LDL-C &lt;1,8 mmol\/L (&lt;70 mg\/dL) \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 ESC 2019 \u03ba\u03b1\u03b9 &lt;1,4 mmol\/L (&lt;55 mg\/dL) \u03b3\u03b9\u03b1 \u03c0\u03bf\u03bb\u03cd \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 ASCVD \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7 ESC 2021.<\/p>\n<p><strong>\u039f\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03c5\u03c0\u03b5\u03c1\u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03bf\u03bb\u03b1\u03b9\u03bc\u03af\u03b1:<\/strong> \u03b7 \u03bc\u03ad\u03b3\u03b9\u03c3\u03c4\u03b7 \u03b1\u03bd\u03b5\u03ba\u03c4\u03ae \u03b4\u03cc\u03c3\u03b7 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7\u03c2 (\u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 80 mg) \u03c3\u03c5\u03c7\u03bd\u03ac \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b5\u03b6\u03b5\u03c4\u03b9\u03bc\u03af\u03bd\u03b7 10 mg \u03ba\u03b1\u03b9\/\u03ae \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 PCSK9 (\u03b1\u03bb\u03b9\u03c1\u03bf\u03ba\u03bf\u03c5\u03bc\u03ac\u03bc\u03c0\/\u03b5\u03b2\u03bf\u03bb\u03bf\u03ba\u03bf\u03c5\u03bc\u03ac\u03bc\u03c0\/\u03b9\u03bd\u03ba\u03bb\u03b9\u03c3\u03b9\u03c1\u03ac\u03bd) \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03c4\u03b5\u03c5\u03be\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c4\u03cc\u03c7\u03c9\u03bd \u03c4\u03c9\u03bd \u03bf\u03b4\u03b7\u03b3\u03b9\u03ce\u03bd.<\/p>\n<p><strong>\u03a7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7:<\/strong> \u03bc\u03b9\u03b1 \u03c6\u03bf\u03c1\u03ac \u03c4\u03b7\u03bd \u03b7\u03bc\u03ad\u03c1\u03b1 \u03bc\u03b5 \u03ae \u03c7\u03c9\u03c1\u03af\u03c2 \u03c4\u03c1\u03bf\u03c6\u03ae. \u0397 \u03b4\u03cc\u03c3\u03b7 \u03c4\u03bf \u03b2\u03c1\u03ac\u03b4\u03c5 \u03b4\u03b5\u03bd \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03c0\u03bb\u03ad\u03bf\u03bd \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c4\u03bf\u03c1\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 (\u03bc\u03b1\u03ba\u03c1\u03ac \u03b7\u03bc\u03b9\u03b6\u03c9\u03ae)\u00b7 \u03bf\u03c0\u03bf\u03b9\u03b1\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae \u03ce\u03c1\u03b1 \u03c4\u03b7\u03c2 \u03b7\u03bc\u03ad\u03c1\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bf\u03b4\u03b5\u03ba\u03c4\u03ae.<\/p>\n<p><strong>\u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7:<\/strong><\/p>\n<ul>\n<li><strong>\u0392\u03b1\u03c3\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7:<\/strong> \u03c0\u03bb\u03ae\u03c1\u03b7\u03c2 \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03bb\u03b9\u03c0\u03b9\u03b4\u03af\u03c9\u03bd, \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03af\u03b5\u03c2 (ALT), \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03b9\u03ba\u03ae \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7 (CK), HbA1c \u03ae \u03bd\u03b7\u03c3\u03c4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7, \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7, \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03c4\u03c1\u03cc\u03c0\u03bf\u03c2 \u03bf\u03c1\u03bc\u03cc\u03bd\u03b7 (TSH) \u03b5\u03ac\u03bd \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03bb\u03b5\u03b3\u03c7\u03b8\u03b5\u03af \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b1.<\/li>\n<li><strong>4-12 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2:<\/strong> \u03b5\u03c0\u03b1\u03bd\u03b1\u03bb\u03ac\u03b2\u03b5\u03c4\u03b5 \u03c4\u03b1 \u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ac \u03b3\u03b9\u03b1 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2. \u0391\u03bd\u03b1\u03bc\u03ad\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03b1\u03c4\u03bf\u03c1\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 40 mg \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03c5\u03c0\u03b9\u03ba\u03ac \u03c4\u03bf LDL-C \u03ba\u03b1\u03c4\u03ac 50%\u00b7 \u03b7 \u03b4\u03cc\u03c3\u03b7 \u03c4\u03c9\u03bd 80 mg \u03ba\u03b1\u03c4\u03ac 55%. \u0391\u03c5\u03be\u03ae\u03c3\u03c4\u03b5 \u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03b5\u03ac\u03bd \u03b4\u03b5\u03bd \u03b5\u03c0\u03b9\u03c4\u03b5\u03c5\u03c7\u03b8\u03b5\u03af \u03bf \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2.<\/li>\n<li><strong>\u0395\u03c4\u03ae\u03c3\u03b9\u03b1:<\/strong> \u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ac, \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03af\u03b5\u03c2 (\u03b5\u03ba\u03c4\u03cc\u03c2 \u03b5\u03ac\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1). CK \u03bc\u03cc\u03bd\u03bf \u03c3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03bc\u03c5\u03ca\u03ba\u03ce\u03bd \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03c9\u03bd, \u03cc\u03c7\u03b9 \u03c1\u03bf\u03c5\u03c4\u03af\u03bd\u03b1\u03c2.<\/li>\n<li><strong>\u0394\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7:<\/strong> CK &gt;10\u00d7 ULN, ALT &gt;3\u00d7 ULN \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03b1\u03bd\u03cc\u03bc\u03b5\u03bd\u03b1, \u03b5\u03c0\u03af\u03bc\u03bf\u03bd\u03bf\u03c2 \u03b1\u03b4\u03b9\u03b5\u03c5\u03ba\u03c1\u03af\u03bd\u03b9\u03c3\u03c4\u03bf\u03c2 \u03bc\u03c5\u03ca\u03ba\u03cc\u03c2 \u03c0\u03cc\u03bd\u03bf\u03c2 \u03bc\u03b5 CK &gt;5\u00d7 ULN, \u03c1\u03b1\u03b2\u03b4\u03bf\u03bc\u03c5\u03cc\u03bb\u03c5\u03c3\u03b7 (\u03c3\u03ba\u03bf\u03c4\u03b5\u03b9\u03bd\u03cc \u03bf\u03cd\u03c1\u03b1, \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1).<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u03a3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd Atorvastatin<\/h2>\n<p><strong>CARDS (2004)<\/strong> \u2014 atorvastatin 10 mg \u03c3\u03b5 2,838 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03c4\u03cd\u03c0\u03bf\u03c5 2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03bc\u03c6\u03b1\u03bd\u03ae \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf \u03bc\u03b5\u03af\u03c9\u03c3\u03b5 \u03c4\u03b9\u03c2 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ad\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ad\u03c2 \u03ba\u03b1\u03c4\u03ac 37% (\u03c0\u03c1\u03c9\u03c4\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03c3\u03c4\u03bf\u03bd \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7). <strong>ASCOT-LLA (2003)<\/strong> \u2014 atorvastatin 10 mg \u03c3\u03b5 10,305 \u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03bc\u03b5\u03af\u03c9\u03c3\u03b5 \u03c4\u03b9\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ad\u03c2 \u03ba\u03b1\u03c4\u03ac 36%. <strong>TNT (2005)<\/strong> \u2014 80 mg vs 10 mg \u03c3\u03b5 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae \u03c3\u03c4\u03b5\u03c6\u03b1\u03bd\u03b9\u03b1\u03af\u03b1 \u03bd\u03cc\u03c3\u03bf\u00b7 \u03b7 \u03c5\u03c8\u03b7\u03bb\u03ae \u03b4\u03cc\u03c3\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b5 \u03c4\u03b9\u03c2 \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ad\u03c2 \u03ba\u03b1\u03c4\u03ac 22%. <strong>PROVE-IT (2004)<\/strong> \u2014 atorvastatin 80 mg vs pravastatin 40 mg \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03bf\u03be\u03cd \u03c3\u03c4\u03b5\u03c6\u03b1\u03bd\u03b9\u03b1\u03af\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf\u00b7 \u03b7 atorvastatin \u03ae\u03c4\u03b1\u03bd \u03b1\u03bd\u03ce\u03c4\u03b5\u03c1\u03b7. <strong>SPARCL (2006)<\/strong> \u2014 atorvastatin 80 mg \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03cc \u03b5\u03c0\u03b5\u03b9\u03c3\u03cc\u03b4\u03b9\u03bf\/TIA \u03bc\u03b5\u03af\u03c9\u03c3\u03b5 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03bd\u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03bf\u03cd \u03b5\u03c0\u03b5\u03b9\u03c3\u03bf\u03b4\u03af\u03bf\u03c5 \u03ba\u03b1\u03c4\u03ac 16%.<\/p>\n<h2 class=\"wp-block-heading\">\u0395\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9 \u0392\u03b1\u03c3\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c3\u03b5 \u0391\u03c0\u03bf\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03a7\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li>\u03a0\u03c1\u03c9\u03c4\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03c5\u03c4\u03b5\u03c1\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b4\u03c5\u03c3\u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03af\u03b1<\/li>\n<li>\u0394\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c5 2 (CARDS) \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03bc\u03b5 \u201c\u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03cc\u201d LDL<\/li>\n<li>\u0394\u03b5\u03c5\u03c4\u03b5\u03c1\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03cc \u03b5\u03c0\u03b5\u03b9\u03c3\u03cc\u03b4\u03b9\u03bf (SPARCL)<\/li>\n<li>\u039f\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03c5\u03c0\u03b5\u03c1\u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03bf\u03bb\u03b1\u03b9\u03bc\u03af\u03b1 (80 mg; \u03c3\u03c5\u03c7\u03bd\u03ac \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03b5\u03b6\u03b5\u03c4\u03b9\u03bc\u03af\u03b2\u03b7 \u03ae \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 PCSK9)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u03a0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2<\/h2>\n<p><strong>\u039f \u03c7\u03c5\u03bc\u03cc\u03c2 \u03b3\u03ba\u03c1\u03ad\u03b9\u03c0\u03c6\u03c1\u03bf\u03c5\u03c4 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac<\/strong> \u2014 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03c4\u03bf \u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc CYP3A4, \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b1\u03c4\u03bf\u03c1\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7\u03c2 2-3 \u03c6\u03bf\u03c1\u03ad\u03c2. \u039c\u03b9\u03ba\u03c1\u03ad\u03c2 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 (\u03ad\u03bd\u03b1 \u03c0\u03bf\u03c4\u03ae\u03c1\u03b9, \u03bc\u03b9\u03b1 \u03c6\u03bf\u03c1\u03ac) \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bf\u03b4\u03b5\u03ba\u03c4\u03ad\u03c2\u00b7 \u03b7 \u03c4\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03b3\u03ba\u03c1\u03ad\u03b9\u03c0\u03c6\u03c1\u03bf\u03c5\u03c4 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c6\u03b5\u03cd\u03b3\u03b5\u03c4\u03b1\u03b9. <strong>\u0399\u03c3\u03c7\u03c5\u03c1\u03bf\u03af \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 CYP3A4<\/strong> (\u03ba\u03bb\u03b1\u03c1\u03b9\u03b8\u03c1\u03bf\u03bc\u03c5\u03ba\u03af\u03bd\u03b7, \u03c1\u03b9\u03c4\u03bf\u03bd\u03b1\u03b2\u03af\u03c1, \u03ba\u03b5\u03c4\u03bf\u03ba\u03bf\u03bd\u03b1\u03b6\u03cc\u03bb\u03b7) \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b1\u03c4\u03bf\u03c1\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03bc\u03c5\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2.<\/p>\n<h2 class=\"wp-block-heading\">\u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/h2>\n<p><strong>\u03a3\u03c5\u03c7\u03bd\u03ac (&gt;1%):<\/strong><\/p>\n<ul>\n<li><strong>\u039c\u03c5\u03b1\u03bb\u03b3\u03af\u03b1 (\u03bc\u03c5\u03ca\u03ba\u03cc\u03c2 \u03c0\u03cc\u03bd\u03bf\u03c2)<\/strong> \u2014 \u03b5\u03bd\u03bf\u03c7\u03bb\u03b7\u03c4\u03b9\u03ba\u03ae \u03c3\u03b5 5-10% \u03c4\u03c9\u03bd \u03c7\u03c1\u03b7\u03c3\u03c4\u03ce\u03bd\u00b7 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03c3\u03c4\u03b1\u03c4\u03b9\u03bd\u03bf-\u03c3\u03c7\u03b5\u03c4\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b1 \u03bc\u03c5\u03ca\u03ba\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03bc\u03b5 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 CK \u03c3\u03b5 0,1-1%. \u03a5\u03c8\u03b7\u03bb\u03cc \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03bf \u03bd\u03bf\u03c3\u03ad\u03bc\u03c0\u03bf: \u03b7 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae SAMSON (2020) \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03ba\u03b1\u03bc\u03af\u03b1 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03bf\u03cd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03b5 \u03b4\u03b9\u03c0\u03bb\u03ac \u03c4\u03c5\u03c6\u03bb\u03ac n-of-1 \u03b4\u03b9\u03b1\u03c3\u03c4\u03b1\u03c5\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c3\u03b5 \u03c0\u03bf\u03bb\u03bb\u03bf\u03cd\u03c2 \u201c\u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b4\u03c5\u03c3\u03b1\u03bd\u03b5\u03be\u03af\u03b1 \u03c3\u03c4\u03b1\u03c4\u03b9\u03bd\u03ce\u03bd\u201d.<\/li>\n<li><strong>\u0389\u03c0\u03b9\u03b1 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03c1\u03b1\u03bd\u03c3\u03b1\u03bc\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2<\/strong> \u2014 3% \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 ALT \u03ba\u03ac\u03c4\u03c9 \u03b1\u03c0\u03cc 3\u00d7 ULN\u00b7 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c0\u03b1\u03c1\u03bf\u03b4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03b4\u03cc\u03c3\u03b7\u03c2.<\/li>\n<li><strong>\u039d\u03b5\u03bf\u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7\u03c2<\/strong> \u2014 \u03b1\u03c0\u03cc\u03bb\u03c5\u03c4\u03b7 \u03c5\u03c0\u03b5\u03c1\u03b2\u03bf\u03bb\u03ae ~0,2 \u03b1\u03bd\u03ac 100 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03b1-\u03ad\u03c4\u03b7, \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03c0\u03c1\u03bf\u03b4\u03b9\u03b1\u03b2\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2. \u03a4\u03bf \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03ba\u03b1\u03c4\u03ac \u03c0\u03bf\u03bb\u03cd \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7.<\/li>\n<li><strong>\u039a\u03b5\u03c6\u03b1\u03bb\u03b1\u03bb\u03b3\u03af\u03b1, \u03b4\u03c5\u03c3\u03c0\u03b5\u03c8\u03af\u03b1, \u03bd\u03b1\u03c5\u03c4\u03af\u03b1<\/strong><\/li>\n<li><strong>\u0391\u03bd\u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03c4\u03cd\u03c3\u03b7\u03c2<\/strong> (\u03c3\u03c0\u03ac\u03bd\u03b9\u03bf\u00b7 \u03bf \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b1\u03c6\u03ae\u03c2)<\/li>\n<li><strong>\u0394\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03cd\u03c0\u03bd\u03bf\u03c5, \u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b8\u03bf\u03bb\u03ce\u03c1\u03b1<\/strong> (\u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b8\u03b7\u03ba\u03b5 \u03b1\u03bb\u03bb\u03ac \u03cc\u03c7\u03b9 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ac \u03c3\u03b5 \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b5\u03bb\u03b5\u03b3\u03c7\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2)<\/li>\n<\/ul>\n<p><strong>\u03a3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b1\u03bb\u03bb\u03ac \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac:<\/strong><\/p>\n<ul>\n<li><strong>\u03a1\u03b1\u03b2\u03b4\u03bf\u03bc\u03c5\u03cc\u03bb\u03c5\u03c3\u03b7<\/strong> (10\u00d7 ULN.<\/li>\n<li><strong>\u0391\u03bd\u03bf\u03c3\u03bf\u03bc\u03b5\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7 \u03bd\u03b5\u03ba\u03c1\u03c9\u03c4\u03b9\u03ba\u03ae \u03bc\u03c5\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1<\/strong> \u2014 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b5\u03c0\u03af\u03bc\u03bf\u03bd\u03b7 \u03bc\u03c5\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03c4\u03b7\u03c2 \u03c3\u03c4\u03b1\u03c4\u03b9\u03bd\u03ae\u03c2\u00b7 \u03bc\u03b5\u03c3\u03bf\u03bb\u03b1\u03b2\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 anti-HMGCR. \u0391\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1.<\/li>\n<li><strong>\u03a3\u03bf\u03b2\u03b1\u03c1\u03ae \u03c5\u03c0\u03b5\u03c1\u03c4\u03c1\u03bf\u03c6\u03b9\u03b1\u03c3\u03bc\u03af\u03bd\u03b7 \/ \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae \u03b2\u03bb\u03ac\u03b2\u03b7 \u03b1\u03c0\u03cc \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1<\/strong> \u2014 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1\u00b7 \u03b4\u03b9\u03b1\u03ba\u03cc\u03c8\u03c4\u03b5 \u03b5\u03ac\u03bd ALT &gt;3\u00d7 ULN \u03bc\u03b5 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ae \u03b1\u03c5\u03be\u03b1\u03bd\u03cc\u03bc\u03b5\u03bd\u03b7 \u03c4\u03c1\u03bf\u03c7\u03b9\u03ac.<\/li>\n<li><strong>\u03a0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ae \u03bd\u03b5\u03c5\u03c1\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1<\/strong> (\u03c3\u03c0\u03ac\u03bd\u03b9\u03b1)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u0391\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li><strong>\u0395\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03b8\u03b7\u03bb\u03b1\u03c3\u03bc\u03cc\u03c2<\/strong> \u2014 \u03bf\u03b9 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03af\u03ba\u03c4\u03bf\u03bd\u03c4\u03b1\u03b9\u00b7 \u03b7 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03bd\u03b5\u03c5\u03c1\u03bf\u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03c4\u03bf\u03c5 \u03b5\u03bc\u03b2\u03c1\u03cd\u03bf\u03c5.<\/li>\n<li><strong>\u0395\u03bd\u03b5\u03c1\u03b3\u03ae \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf\u03c2<\/strong> \u03ae \u03b1\u03bd\u03b5\u03be\u03ae\u03b3\u03b7\u03c4\u03b7 \u03b5\u03c0\u03af\u03bc\u03bf\u03bd\u03b7 ALT &gt;3\u00d7 ULN.<\/li>\n<li><strong>\u03a0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03c1\u03b1\u03b2\u03b4\u03bf\u03bc\u03c5\u03cc\u03bb\u03c5\u03c3\u03b7 \u03ae \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03b4\u03c5\u03c3\u03b1\u03bd\u03b5\u03be\u03af\u03b1 \u03c3\u03b5 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2<\/strong> \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c3\u03b5 \u03b4\u03b9\u03c0\u03bb\u03ae \u03c4\u03c5\u03c6\u03bb\u03ae \u03b5\u03c0\u03b1\u03bd\u03ad\u03ba\u03b8\u03b5\u03c3\u03b7.<\/li>\n<li><strong>\u03a4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ce\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03c9\u03bd CYP3A4<\/strong> (\u03b3\u03b9\u03b1 \u03b1\u03c4\u03bf\u03c1\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7): \u03ba\u03bb\u03b1\u03c1\u03b9\u03b8\u03c1\u03bf\u03bc\u03c5\u03ba\u03af\u03bd\u03b7, \u03b9\u03c4\u03c1\u03b1\u03ba\u03bf\u03bd\u03b1\u03b6\u03cc\u03bb\u03b7, \u03c1\u03b9\u03c4\u03bf\u03bd\u03b1\u03b2\u03af\u03c1 \u2014 \u03b4\u03b9\u03b1\u03ba\u03cc\u03c8\u03c4\u03b5 \u03c4\u03b7 \u03c3\u03c4\u03b1\u03c4\u03b9\u03bd\u03ae \u03ae \u03b1\u03bb\u03bb\u03ac\u03be\u03c4\u03b5 \u03c3\u03b5 \u03c1\u03bf\u03c3\u03bf\u03c5\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7\/\u03c0\u03c1\u03b1\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7.<\/li>\n<li>\u03a5\u03c0\u03b5\u03c1\u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03c4\u03b7 \u03c3\u03c4\u03b1\u03c4\u03b9\u03bd\u03ae.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03a6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd<\/h2>\n<ul>\n<li><strong>\u0399\u03c3\u03c7\u03c5\u03c1\u03bf\u03af \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 CYP3A4 \u2014 \u039a\u03a1\u0399\u03a4\u0399\u039a\u039f.<\/strong> \u039a\u03bb\u03b1\u03c1\u03b9\u03b8\u03c1\u03bf\u03bc\u03c5\u03ba\u03af\u03bd\u03b7, \u03b5\u03c1\u03c5\u03b8\u03c1\u03bf\u03bc\u03c5\u03ba\u03af\u03bd\u03b7, \u03b9\u03c4\u03c1\u03b1\u03ba\u03bf\u03bd\u03b1\u03b6\u03cc\u03bb\u03b7, \u03ba\u03b5\u03c4\u03bf\u03ba\u03bf\u03bd\u03b1\u03b6\u03cc\u03bb\u03b7, \u03c1\u03b9\u03c4\u03bf\u03bd\u03b1\u03b2\u03af\u03c1, \u03ba\u03bf\u03bc\u03c0\u03b9\u03ba\u03b9\u03c3\u03c4\u03ac\u03c4, \u03ba\u03c5\u03ba\u03bb\u03bf\u03c3\u03c0\u03bf\u03c1\u03af\u03bd\u03b7 \u2014 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b1\u03c4\u03bf\u03c1\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03b9\u03bd\u03ae\u03c2 2-10 \u03c6\u03bf\u03c1\u03ad\u03c2. \u0394\u03b9\u03b1\u03ba\u03cc\u03c8\u03c4\u03b5 \u03c4\u03b7 \u03c3\u03c4\u03b1\u03c4\u03b9\u03bd\u03ae \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c3\u03cd\u03bd\u03c4\u03bf\u03bc\u03c9\u03bd \u03b1\u03bd\u03c4\u03b9\u03b2\u03b9\u03bf\u03c4\u03b9\u03ba\u03ce\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03b9\u03ce\u03bd\u00b7 \u03b1\u03bb\u03bb\u03ac\u03be\u03c4\u03b5 \u03c3\u03b5 \u03c1\u03bf\u03c3\u03bf\u03c5\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 \u03ae \u03c0\u03c1\u03b1\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 \u03b3\u03b9\u03b1 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c3\u03c5\u03bd\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 CYP3A4 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2.<\/li>\n<li><strong>\u03a7\u03c5\u03bc\u03cc\u03c2 \u03b3\u03ba\u03c1\u03ad\u03b9\u03c0\u03c6\u03c1\u03bf\u03c5\u03c4<\/strong> \u2014 \u03b1\u03c0\u03bf\u03c6\u03b5\u03cd\u03b3\u03b5\u03c4\u03b5 \u03c4\u03b7\u03bd \u03c4\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03c7\u03c1\u03ae\u03c3\u03b7 \u03bc\u03b5 \u03b1\u03c4\u03bf\u03c1\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 (\u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 2-3 \u03c6\u03bf\u03c1\u03ad\u03c2).<\/li>\n<li><strong>\u03a6\u03b9\u03b2\u03c1\u03ac\u03c4\u03b5\u03c2 (\u03b3\u03b5\u03bc\u03c6\u03b9\u03bc\u03c0\u03c1\u03bf\u03b6\u03af\u03bb\u03b7, \u03c6\u03b5\u03bd\u03bf\u03c6\u03b9\u03b2\u03c1\u03ac\u03c4\u03b7)<\/strong> \u2014 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03bc\u03c5\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2. \u0397 \u03b3\u03b5\u03bc\u03c6\u03b9\u03bc\u03c0\u03c1\u03bf\u03b6\u03af\u03bb\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c7\u03b5\u03b9\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7\u00b7 \u03b7 \u03c6\u03b5\u03bd\u03bf\u03c6\u03b9\u03b2\u03c1\u03ac\u03c4\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03c0\u03c1\u03bf\u03c4\u03b9\u03bc\u03ce\u03bc\u03b5\u03bd\u03bf \u03c6\u03b9\u03b2\u03c1\u03ac\u03c4\u03b7 \u03b3\u03b9\u03b1 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc. \u039a\u03c1\u03b1\u03c4\u03ae\u03c3\u03c4\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03cd\u03c2 \u03b3\u03b9\u03b1 \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03c6\u03c1\u03bf\u03bd\u03c4\u03af\u03b4\u03b1 \u03b4\u03c5\u03c3\u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03af\u03b1\u03c2.<\/li>\n<li><strong>\u039d\u03b9\u03b1\u03c3\u03af\u03bd\u03b7 \u03c5\u03c8\u03b7\u03bb\u03ae\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2<\/strong> \u2014 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03bc\u03c5\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2. \u0397 \u03bd\u03b9\u03b1\u03c3\u03af\u03bd\u03b7 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ae\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2 (1-2 g) \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b1\u03bd\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9.<\/li>\n<li><strong>\u0392\u03b1\u03c1\u03c6\u03b1\u03c1\u03af\u03bd\u03b7<\/strong> \u2014 \u03bc\u03b9\u03ba\u03c1\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 INR \u03bc\u03b5 \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7\u03c2\u00b7 \u03b5\u03bb\u03ad\u03b3\u03be\u03c4\u03b5 \u03c4\u03bf INR 1 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7. \u0394\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b1\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b7.<\/li>\n<li><strong>\u039d\u03c4\u03b9\u03b3\u03ba\u03bf\u03be\u03af\u03bd\u03b7<\/strong> \u2014 \u03bc\u03b9\u03ba\u03c1\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03bf\u03c5 \u03b4\u03b9\u03b3\u03bf\u03be\u03af\u03bd\u03b7\u03c2 \u03bc\u03b5 \u03b1\u03c4\u03bf\u03c1\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 (P-\u03b3\u03bb\u03c5\u03ba\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7)\u00b7 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae.<\/li>\n<li><strong>\u0391\u03bb\u03ba\u03bf\u03cc\u03bb<\/strong> \u2014 \u03b7 \u03c5\u03c0\u03b5\u03c1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b2\u03bb\u03ac\u03b2\u03b7\u03c2. \u0397 \u03bc\u03ad\u03c4\u03c1\u03b9\u03b1 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bf\u03b4\u03b5\u03ba\u03c4\u03ae.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7<\/h2>\n<p>\u0391\u03c0\u03bf\u03b8\u03b7\u03ba\u03b5\u03cd\u03c3\u03c4\u03b5 \u03c4\u03bf Atorvatin \u03c3\u03b5 \u03b8\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03af\u03b1 \u03ba\u03ac\u03c4\u03c9 \u03c4\u03c9\u03bd 25\u00b0C \u03c3\u03c4\u03b7\u03bd \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u03bc\u03b5 \u03c6\u03c5\u03c3\u03b1\u03bb\u03af\u03b4\u03b5\u03c2. \u039a\u03c1\u03b1\u03c4\u03ae\u03c3\u03c4\u03b5 \u03bc\u03b1\u03ba\u03c1\u03b9\u03ac \u03b1\u03c0\u03cc \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac.<\/p>\n<h2 id=\"faqs\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3 class=\"wp-block-heading\">\u03a0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c0\u03ac\u03c1\u03c9 \u03c4\u03bf Atorvatin \u03c4\u03bf \u03b2\u03c1\u03ac\u03b4\u03c5;<\/h3>\n<p>\u038c\u03c7\u03b9 \u2014 \u03b7 \u03b1\u03c4\u03bf\u03c1\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03b7\u03bc\u03b9\u03b6\u03c9\u03ae 20-30 \u03c9\u03c1\u03ce\u03bd, \u03b1\u03c1\u03ba\u03b5\u03c4\u03ae \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c8\u03b5\u03b9 \u03c4\u03bf\u03bd ~24\u03c9\u03c1\u03bf \u03ba\u03cd\u03ba\u03bb\u03bf \u03bd\u03c5\u03c7\u03c4\u03b5\u03c1\u03b9\u03bd\u03ae\u03c2 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7\u03c2 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03b1\u03bd\u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c7\u03c1\u03bf\u03bd\u03bf\u03b4\u03b9\u03ac\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 \u03b4\u03cc\u03c3\u03b7\u03c2. \u0397 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03bf \u03c0\u03c1\u03c9\u03af \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03bd\u03c4\u03ac\u03be\u03b5\u03b9. \u039f \u03ba\u03b1\u03bd\u03cc\u03bd\u03b1\u03c2 \u201c\u03bd\u03b1 \u03c0\u03b1\u03af\u03c1\u03bd\u03b5\u03c4\u03b5 \u03c4\u03b9\u03c2 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 \u03c4\u03bf \u03b2\u03c1\u03ac\u03b4\u03c5\u201d \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 \u03bc\u03b5 \u03c3\u03cd\u03bd\u03c4\u03bf\u03bc\u03b7 \u03b7\u03bc\u03b9\u03b6\u03c9\u03ae (\u03c3\u03b9\u03bc\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7, \u03bb\u03bf\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7).<\/p>\n<h3 class=\"wp-block-heading\">\u03a4\u03b9 \u03bd\u03b1 \u03ba\u03ac\u03bd\u03c9 \u03b1\u03bd \u03ad\u03c7\u03c9 \u03bc\u03c5\u03ca\u03ba\u03bf\u03cd\u03c2 \u03c0\u03cc\u03bd\u03bf\u03c5\u03c2 \u03bc\u03b5 \u03c4\u03bf Atorvatin;<\/h3>\n<p>\u03a3\u03c5\u03c7\u03bd\u03cc \u03ba\u03b1\u03b9 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b5\u03c0\u03b9\u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf. \u0395\u03bb\u03ad\u03b3\u03be\u03c4\u03b5 \u03c4\u03b7\u03bd \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03b9\u03ba\u03ae \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7 (CK). \u0391\u03bd \u03b7 CK \u03b5\u03af\u03bd\u03b1\u03b9 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae, \u03bf\u03b9 \u03c0\u03cc\u03bd\u03bf\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b4\u03b5\u03bd \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 \u2014 \u03b7 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae SAMSON (2020) \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03cc\u03c4\u03b9 \u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u201c\u03b4\u03c5\u03c3\u03b1\u03bd\u03b5\u03be\u03af\u03b1 \u03c3\u03b5 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2\u201d \u03b5\u03af\u03c7\u03b1\u03bd \u03af\u03b4\u03b9\u03bf\u03c5\u03c2 \u03c0\u03cc\u03bd\u03bf\u03c5\u03c2 \u03bc\u03b5 \u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03cc \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03c3\u03b5 \u03b4\u03b9\u03c0\u03bb\u03ae \u03c4\u03c5\u03c6\u03bb\u03ae \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae. \u0395\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2: \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03c3\u03c4\u03b5 \u03c4\u03b7 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 \u03bc\u03b5 \u03c3\u03c5\u03bc\u03c0\u03bb\u03ae\u03c1\u03c9\u03c3\u03b7 \u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7\u03c2 D (\u03b5\u03ac\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ad\u03bb\u03bb\u03b5\u03b9\u03c8\u03b7), \u03b4\u03bf\u03ba\u03b9\u03bc\u03ac\u03c3\u03c4\u03b5 \u03c3\u03c5\u03bd\u03ad\u03bd\u03b6\u03c5\u03bc\u03bf Q10 (\u03b1\u03b4\u03cd\u03bd\u03b1\u03bc\u03b7 \u03b1\u03c0\u03cc\u03b4\u03b5\u03b9\u03be\u03b7 \u03b1\u03bb\u03bb\u03ac \u03c7\u03b1\u03bc\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5), \u03b1\u03bb\u03bb\u03ac\u03be\u03c4\u03b5 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 (\u03b7 \u03c1\u03bf\u03c3\u03bf\u03c5\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03bc\u03c5\u03ca\u03ba\u03ce\u03bd \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c3\u03b9\u03bc\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03c4\u03bf\u03c1\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7), \u03bc\u03b5\u03b9\u03ce\u03c3\u03c4\u03b5 \u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03ae \u03c5\u03b9\u03bf\u03b8\u03b5\u03c4\u03ae\u03c3\u03c4\u03b5 \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03c3\u03c3\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b7\u03bc\u03b5\u03c1\u03ae\u03c3\u03b9\u03b1 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7. \u03a3\u03c4\u03b1\u03bc\u03b1\u03c4\u03ae\u03c3\u03c4\u03b5 \u03bc\u03cc\u03bd\u03bf \u03b1\u03bd CK &gt;10\u00d7 ULN, \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c4\u03b1 \u03ae \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b5\u03b9\u03bc\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1.<\/p>\n<h3 class=\"wp-block-heading\">\u0398\u03b1 \u03bc\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03b5\u03b9 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03c4\u03bf Atorvatin;<\/h3>\n<p>\u039f\u03b9 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd \u03bc\u03b9\u03ba\u03c1\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03bd\u03b5\u03b1\u03c1\u03ae \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u2014 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 1 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03ba\u03c1\u03bf\u03cd\u03c3\u03bc\u03b1 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03b1\u03bd\u03ac 1.000 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03b5\u03c4\u03b7\u03c3\u03af\u03c9\u03c2, \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03c5\u03c8\u03b7\u03bb\u03cc \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 (\u03c5\u03c0\u03ad\u03c1\u03b2\u03b1\u03c1\u03bf, \u03c0\u03c1\u03bf\u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7\u03c2, \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc). \u0397 \u03af\u03b4\u03b9\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b1\u03c0\u03bf\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 5-10 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ac \u03c3\u03c5\u03bc\u03b2\u03ac\u03bd\u03c4\u03b1 \u03b1\u03bd\u03ac 1.000 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03b5\u03c4\u03b7\u03c3\u03af\u03c9\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03af\u03b4\u03b9\u03b5\u03c2 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03b9\u03ba\u03ad\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u2014 \u03b5\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03c4\u03bf \u03ba\u03b1\u03b8\u03b1\u03c1\u03cc \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03c4\u03bf\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc. \u039c\u03b7\u03bd \u03c3\u03c4\u03b1\u03bc\u03b1\u03c4\u03ac\u03c4\u03b5 \u03c4\u03b7 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 \u03bc\u03cc\u03bd\u03bf \u03bb\u03cc\u03b3\u03c9 \u03c4\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7.<\/p>\n<h3 class=\"wp-block-heading\">\u039c\u03c0\u03bf\u03c1\u03ce \u03bd\u03b1 \u03c0\u03ac\u03c1\u03c9 Atorvatin \u03bc\u03b5 \u03c7\u03c5\u03bc\u03cc \u03b3\u03ba\u03c1\u03ad\u03b9\u03c0\u03c6\u03c1\u03bf\u03c5\u03c4;<\/h3>\n<p>\u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bf\u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03bc\u03b9\u03ba\u03c1\u03ad\u03c2 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03c7\u03c5\u03bc\u03bf\u03cd \u03b3\u03ba\u03c1\u03ad\u03b9\u03c0\u03c6\u03c1\u03bf\u03c5\u03c4 (\u03ad\u03bd\u03b1 \u03c0\u03bf\u03c4\u03ae\u03c1\u03b9) \u03ba\u03b1\u03c4\u03ac \u03ba\u03b1\u03b9\u03c1\u03bf\u03cd\u03c2. \u0397 \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b1\u03c4\u03bf\u03c1\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7\u03c2 (2-3 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03bc\u03ad\u03c3\u03c9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u03c4\u03bf\u03c5 CYP3A4 \u03c3\u03c4\u03bf \u03ad\u03bd\u03c4\u03b5\u03c1\u03bf) \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03bc\u03c5\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2. \u0391\u03bd \u03c0\u03af\u03bd\u03b5\u03c4\u03b5 \u03c7\u03c5\u03bc\u03cc \u03b3\u03ba\u03c1\u03ad\u03b9\u03c0\u03c6\u03c1\u03bf\u03c5\u03c4 \u03c4\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac, \u03bc\u03b5\u03c4\u03b1\u03b2\u03b5\u03af\u03c4\u03b5 \u03c3\u03b5 \u03c1\u03bf\u03c3\u03bf\u03c5\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 \u03ae \u03c0\u03c1\u03b1\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7, \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03b7 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf \u03b3\u03ba\u03c1\u03ad\u03b9\u03c0\u03c6\u03c1\u03bf\u03c5\u03c4.<\/p>\n<h3 class=\"wp-block-heading\">\u03a0\u03cc\u03c3\u03bf \u03ba\u03b1\u03b9\u03c1\u03cc \u03b8\u03b1 \u03c7\u03c1\u03b5\u03b9\u03b1\u03c3\u03c4\u03b5\u03af \u03bd\u03b1 \u03c0\u03ac\u03c1\u03c9 Atorvatin;<\/h3>\n<p>\u03a3\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c3\u03c7\u03b5\u03b4\u03cc\u03bd \u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2, \u03b3\u03b9\u03b1 \u03b1\u03cc\u03c1\u03b9\u03c3\u03c4\u03bf \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03cc \u03b4\u03b9\u03ac\u03c3\u03c4\u03b7\u03bc\u03b1. \u0397 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03bc\u03b9\u03b1\u03c2 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7\u03c2 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03b1\u03bd\u03b1\u03ba\u03bf\u03cd\u03c6\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 LDL-C \u03b5\u03bd\u03c4\u03cc\u03c2 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b7 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c3\u03af\u03b1 \u03c7\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 \u03bc\u03b7\u03bd\u03ce\u03bd. \u039f\u03b9 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03b9\u03b1 \u03b2\u03af\u03bf\u03c5 \u03c0\u03c1\u03bf\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03b8\u03b7\u03c1\u03bf\u03c3\u03ba\u03bb\u03b7\u03c1\u03c9\u03c4\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf, \u03cc\u03c7\u03b9 \u03bc\u03b9\u03b1 \u03c3\u03cd\u03bd\u03c4\u03bf\u03bc\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c0\u03bf\u03c1\u03b5\u03af\u03b1.<\/p>\n<h3 class=\"wp-block-heading\">\u039c\u03c0\u03bf\u03c1\u03ce \u03bd\u03b1 \u03c0\u03ac\u03c1\u03c9 Atorvatin \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7\u03c2;<\/h3>\n<p>\u038c\u03c7\u03b9 \u2014 \u03bf\u03b9 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03af\u03ba\u03c4\u03b9\u03ba\u03b5\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03b8\u03b7\u03bb\u03b1\u03c3\u03bc\u03bf\u03cd. \u0397 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03bd\u03b5\u03c5\u03c1\u03bf\u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03c4\u03bf\u03c5 \u03b5\u03bc\u03b2\u03c1\u03cd\u03bf\u03c5\u00b7 \u03bf\u03b9 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 \u03b4\u03b9\u03b1\u03c3\u03c7\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03c0\u03bb\u03b1\u03ba\u03bf\u03cd\u03bd\u03c4\u03b1. \u0394\u03b9\u03b1\u03ba\u03cc\u03c8\u03c4\u03b5 \u03c4\u03b7 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7\u00b7 \u03b1\u03bd \u03b7 \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03ac\u03c4\u03b9\u03c3\u03c4\u03b7, \u03b4\u03b9\u03b1\u03ba\u03cc\u03c8\u03c4\u03b5 \u03b1\u03bc\u03ad\u03c3\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03b6\u03b7\u03c4\u03ae\u03c3\u03c4\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5\u03c2 \u03bc\u03b5 \u03ad\u03bd\u03b1\u03bd \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc. \u039f\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03ae \u03c5\u03c0\u03b5\u03c1\u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03bf\u03bb\u03b1\u03b9\u03bc\u03af\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03bd\u03b1 \u03b1\u03bd\u03b1\u03b2\u03ac\u03bb\u03bf\u03c5\u03bd \u03bc\u03b5 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03b8\u03b7\u03bb\u03b1\u03c3\u03bc\u03bf\u03cd.<\/p>\n<h3 class=\"wp-block-heading\">\u03a0\u03bf\u03cd \u03bc\u03c0\u03bf\u03c1\u03ce \u03bd\u03b1 \u03b1\u03b3\u03bf\u03c1\u03ac\u03c3\u03c9 Atorvatin online;<\/h3>\n<p>\u039c\u03c0\u03bf\u03c1\u03b5\u03af\u03c4\u03b5 \u03bd\u03b1 \u03b1\u03b3\u03bf\u03c1\u03ac\u03c3\u03b5\u03c4\u03b5 Atorvatin (\u03b1\u03c4\u03bf\u03c1\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 5 mg, 30-180 \u03b4\u03b9\u03c3\u03ba\u03af\u03b1) \u03b1\u03c0\u03cc \u03c4\u03bf MedsBase \u03bc\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae.<\/p>\n<h2 class=\"wp-block-heading\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u039a\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ac &amp; \u03a5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03ac \u03a6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/aldactone\/\">Aldactone \u2014 \u03a3\u03c0\u03b9\u03c1\u03bf\u03bd\u03bf\u03bb\u03b1\u03ba\u03c4\u03cc\u03bd\u03b7 (\u03bc\u03b7 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ae\u03c2 MR)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/amlode\/\">Amlode \u2014 \u0391\u03bc\u03bf\u03bb\u03bf\u03b4\u03b9\u03c0\u03af\u03bd\u03b7 (CCB)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/lanoxin\/\">Lanoxin \u2014 \u0394\u03b9\u03b3\u03bf\u03be\u03af\u03bd\u03b7 0.25 mg (\u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03cc \u03b3\u03bb\u03c5\u03ba\u03bf\u03b6\u03af\u03c4\u03b7)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/lotensyl\/\">Lotensyl \u2014 \u039a\u03b9\u03bb\u03bd\u03b9\u03b4\u03b9\u03c0\u03af\u03bd\u03b7 10\/20 mg (L+N-type CCB)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/tenoric\/\">Tenoric \u2014 \u03a3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 Atenolol + Chlorthalidone<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/zivast-am\/\">Zivast AM \u2014 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 Atorvastatin + Amlodipine<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/high-blood-pressure-medication\/\"><strong>\u03a0\u03b5\u03c1\u03b9\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c3\u03b5 \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03a6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b3\u03b9\u03b1 \u03a5\u03c8\u03b7\u03bb\u03ae \u03a0\u03af\u03b5\u03c3\u03b7 \u0391\u03af\u03bc\u03b1\u03c4\u03bf\u03c2<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 \u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u0391\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u0395\u03c5\u03b8\u03cd\u03bd\u03b7\u03c2.<\/strong> \u0391\u03c5\u03c4\u03ae \u03b7 \u03c3\u03b5\u03bb\u03af\u03b4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b3\u03b9\u03b1 \u03b5\u03bd\u03b7\u03bc\u03b5\u03c1\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c3\u03ba\u03bf\u03c0\u03bf\u03cd\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03c4\u03b7\u03bd \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03ae \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1\u03bd \u03ba\u03b1\u03c4\u03b1\u03be\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b1\u03b3\u03b3\u03b5\u03bb\u03bc\u03b1\u03c4\u03af\u03b1 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2. \u0397 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7, \u03b7 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03b1\u03c1\u03c1\u03c5\u03b8\u03bc\u03af\u03b5\u03c2 \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7, \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03b4\u03cc\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc \u2014 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b5 \u03b2-\u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c5\u03c0\u03cc \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b2\u03bb\u03b5\u03c8\u03b7.<\/div>\n<h3 class=\"wp-block-heading\">\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n<p>\u03a4\u03bf Atorvatin \u03c0\u03b1\u03c1\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd WHO-GMP \u03bc\u03b5 \u03c0\u03bb\u03ae\u03c1\u03b7 \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03af\u03c9\u03c3\u03b7 COA. \u03a0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bc\u03b5 \u03c0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b5\u03c2 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ad\u03c2 \u03c3\u03b5 \u03b1\u03c0\u03bb\u03ae, \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1, \u03ba\u03b1\u03b9 \u03ba\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <a href=\"\/el\/medsbase-re-shipment-assurance-policy\/\">\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/a>. \u039f \u03c4\u03af\u03c4\u03bb\u03bf\u03c2 \u03c7\u03c1\u03ad\u03c9\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7\u03bd \u03ba\u03ac\u03c1\u03c4\u03b1 \u03c3\u03b1\u03c2 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03b9 \u03c4\u03bf\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd (\u03ad\u03bd\u03b1\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1), \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2<\/h3>\n<p>\u0386\u03bb\u03bb\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 \u03c3\u03b5 <strong>\u03a7\u03c1\u03cc\u03bd\u03b9\u03b5\u03c2 \u03a0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2<\/strong> \u03c0\u03bf\u03c5 \u03bf\u03b9 \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/glycomet-sr\/\">Glycomet SR<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/tegrital\/\">Tegrital 100 mg \u039c\u03b1\u03c3\u03b7\u03c4\u03cc (\u039a\u03b1\u03c1\u03b2\u03b1\u03bc\u03b1\u03b6\u03b5\u03c0\u03af\u03bd\u03b7) \u2014 \u039d\u03b5\u03c5\u03c1\u03b1\u03bb\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03a4\u03c1\u03b9\u03b4\u03cd\u03bc\u03bf\u03c5 &amp; \u03a3\u03c0\u03b1\u03c3\u03bc\u03bf\u03af<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/ramisave\/\">Ramisave<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/diamox\/\">Diamox<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/laregab-at\/\">Laregab AT (\u0393\u03ba\u03b1\u03bc\u03c0\u03b1\u03c0\u03b5\u03bd\u03c4\u03af\u03bd\u03b7 300 mg + \u0391\u03bc\u03b9\u03c4\u03c1\u03b9\u03c0\u03c4\u03c5\u03bb\u03af\u03bd\u03b7 10 mg) \u2014 \u0394\u03cd\u03c3\u03ba\u03bf\u03bb\u03bf\u03c2 \u039d\u03b5\u03c5\u03c1\u03b9\u03ba\u03cc\u03c2 \u03a0\u03cc\u03bd\u03bf\u03c2<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u03a4\u03bf Atorvatin \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b1\u03bc\u03c0\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b1\u03c4\u03bf\u03c1\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7\u03c2 5 mg \u2014 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03b7 \u03c5\u03c0\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03b4\u03cc\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ae\u03c0\u03b9\u03b1 \u03c4\u03b9\u03c4\u03bb\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7 (\u03b5\u03c5\u03c0\u03b1\u03b8\u03b5\u03af\u03c2 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03b9, \u03b5\u03c5\u03b1\u03af\u03c3\u03b8\u03b7\u03c4\u03bf\u03b9 \u03c3\u03b5 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 CYP3A4, \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03bc\u03c5\u03b1\u03bb\u03b3\u03af\u03b1\u03c2 \u03c3\u03b5 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7\u03c2). \u0397 \u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03b1\u03c4\u03bf\u03c1\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 \u03be\u03b5\u03ba\u03b9\u03bd\u03ac \u03b1\u03c0\u03cc 10-20 mg\u00b7 \u03c4\u03b1 5 mg \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b2\u03ae\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03bc\u03b5 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03b1\u03bd\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1. \u0397 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 LDL \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 30-35% \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03bf\u03cd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03b1 5 mg. \u03a0\u03bb\u03ae\u03c1\u03b5\u03c2 \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03c9\u03bd \u03c4\u03b7\u03c2 \u03b1\u03c4\u03bf\u03c1\u03b2\u03b1\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7\u03c2 \u2014 \u03c0\u03c1\u03c9\u03c4\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03c5\u03c4\u03b5\u03c1\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ce\u03bd \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03c9\u03bd.<\/p>","protected":false},"featured_media":61589,"comment_status":"closed","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3260,3356,3953],"product_tag":[3435,5065],"class_list":{"0":"post-61588","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-heart-blood-pressure","9":"product_cat-high-blood-pressure-medication","10":"product_cat-high-cholesterol-treatments","11":"product_tag-atorvastatin","12":"product_tag-atorvatin","14":"first","15":"instock","16":"shipping-taxable","17":"purchasable","18":"product-type-variable","19":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/61588","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=61588"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/61589"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=61588"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=61588"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=61588"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=61588"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}