{"id":68840,"date":"2026-02-25T16:10:01","date_gmt":"2026-02-25T16:10:01","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&#038;p=68840"},"modified":"2026-05-21T07:14:12","modified_gmt":"2026-05-21T07:14:12","slug":"nad","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/nad\/","title":{"rendered":"NAD\u207a"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background: #fff8e1; border-left: 4px solid #f5a623; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<h3 style=\"margin: 0 0 8px 0; font-size: 16px; color: #1a4a6b;\">Quick Answer \u2014 What is NAD+?<\/h3>\n<p style=\"margin: 0;\"><strong>NAD+<\/strong> (nicotinamide adenine dinucleotide) is a fundamental coenzyme present in every cell, central to energy metabolism, sirtuin-pathway longevity signaling, and PARP-mediated DNA repair. Cellular NAD+ levels decline markedly with age, making it one of the most-studied molecules in longevity research. Supplied in 100\u00a0mg to 1000\u00a0mg lyophilized vials for laboratory research use only.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background: #f4f8fb; border: 1px solid #d8e3eb; padding: 12px 16px; margin: 16px 0; border-radius: 4px; font-size: 14px;\"><strong>\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong> \u0395\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03bb\u03c5\u03bf\u03c6\u03b9\u03bb\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1 \u00b7 HPLC \u03ba\u03b1\u03b8\u03b1\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u226599% (COA \u03ba\u03b1\u03c4\u03cc\u03c0\u03b9\u03bd \u03b1\u03b9\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2) \u00b7 \u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae \u03c3\u03b5 \u03b8\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03af\u03b1 \u00b7 \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03c9\u03bd \u00b7 1,400+ \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 <a href=\"https:\/\/medsbase.com\/el\/reviews\/\">\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size: 14px; color: #444; margin: 8px 0 18px;\">\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\"><strong>\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n<table class=\"medsbase-spec-table\" style=\"width: 100%; border-collapse: collapse; margin: 18px 0; font-size: 14px;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 8px 12px; text-align: left; width: 30%;\">\u03a0\u03c1\u03bf\u03b4\u03b9\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae<\/th>\n<th style=\"padding: 8px 12px; text-align: left;\">\u039b\u03b5\u03c0\u03c4\u03bf\u03bc\u03ad\u03c1\u03b5\u03b9\u03b1<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u0391\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2 CAS<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">53-84-9<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u039c\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03a4\u03cd\u03c0\u03bf\u03c2<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">C<sub>21<\/sub>H<sub>27<\/sub>N<sub>7<\/sub>O<sub>14<\/sub>P<sub>2<\/sub><\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u039c\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc \u0392\u03ac\u03c1\u03bf\u03c2<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">663.43 Da<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u0391\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03af\u03b1<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">n\/a (dinucleotide coenzyme \u2014 not a peptide)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u039c\u03bf\u03c1\u03c6\u03ae<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u03a5\u03b1\u03bb\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c3\u03ba\u03cc\u03bd\u03b7 (\u03ae \u03cc\u03c0\u03c9\u03c2 \u03c0\u03b1\u03c1\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9)<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u039a\u03b1\u03b8\u03b1\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u226599% (HPLC \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf, COA \u03ba\u03b1\u03c4\u03cc\u03c0\u03b9\u03bd \u03b1\u03b9\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Lyophilized: 2\u20138\u00a0\u00b0C (refrigerator) for working stock; \u221220\u00a0\u00b0C for long-term storage of unopened vials. Reconstituted: 2\u20138\u00a0\u00b0C, use within ~30 days. Protect from light \u2014 NAD<sup>+<\/sup> oxidizes readily. Do not freeze\u2013thaw the reconstituted solution.<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u0394\u03b9\u03b1\u03bb\u03c5\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u0392\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03bf\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03bd\u03b5\u03c1\u03cc (\u03c0\u03c1\u03bf\u03c4\u03b5\u03af\u03bd\u03b5\u03c4\u03b1\u03b9) \u03ae \u03c3\u03c4\u03b5\u03b9\u03c1\u03c9\u03bc\u03ad\u03bd\u03bf \u03bd\u03b5\u03c1\u03cc \u03b3\u03b9\u03b1 \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03ac \u03b4\u03b9\u03b1\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b7\u03c2<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u0395\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03a7\u03c1\u03ae\u03c3\u03b7<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u039c\u03cc\u03bd\u03bf \u03b3\u03b9\u03b1 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1. \u0394\u03b5\u03bd \u03c0\u03c1\u03bf\u03bf\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 \u03ae \u03b6\u03ce\u03b1.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><!-- \/medsbase-tldr-answer --><\/p>\n<h2>What Is NAD+?<\/h2>\n<p><strong>NAD+<\/strong> (nicotinamide adenine dinucleotide) is not strictly a peptide \u2014 it is a dinucleotide coenzyme composed of two nucleotides joined through their phosphate groups. But it is the most widely researched single molecule in the longevity and cellular-aging literature, and is commonly supplied through peptide-research suppliers alongside peptide compounds for convenience of researchers working on multi-factor cellular-aging studies.<\/p>\n<p>NAD+ is found in every living cell and functions as a substrate for three major enzyme families: <strong>oxidoreductases<\/strong> (energy metabolism), <strong>sirtuins<\/strong> (longevity signaling, gene silencing), and <strong>PARPs<\/strong> (DNA damage response). Cellular NAD+ levels decline by approximately 50% between age 30 and 70 in most tissues \u2014 the &#8220;NAD+ decline&#8221; \u2014 and restoring this decline is a central hypothesis in the longevity research community (Yoshino, Baur &amp; Imai, Cell Metab 2018).<\/p>\n<p>Molecular weight 663.4\u00a0Da, empirical formula C<sub>21<\/sub>H<sub>27<\/sub>N<sub>7<\/sub>O<sub>14<\/sub>P<sub>2<\/sub>. Supplied as a high-purity lyophilized powder for reconstitution with bacteriostatic water. NAD+ is <strong>\u03bc\u03cc\u03bd\u03bf \u03b3\u03b9\u03b1 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1<\/strong> and is not intended for human or veterinary diagnosis or therapy. For deeper mechanism, longevity-research context, and alternative precursor compounds (NR, NMN), see our full <a href=\"https:\/\/medsbase.com\/el\/nad-plus-coenzyme-longevity-guide\/\">NAD+ research guide<\/a>.<\/p>\n<h2>Mechanism of Action \u2014 Three Essential Pathways<\/h2>\n<p>NAD+ participates in cellular biology through three mechanistically distinct but interdependent enzyme families:<\/p>\n<ul>\n<li><strong>Redox coenzyme (energy metabolism)<\/strong> \u2014 NAD+ is the central electron carrier in glycolysis, the TCA cycle, and oxidative phosphorylation. Every step that extracts energy from food ultimately transfers electrons to NAD+ (forming NADH) which then drives ATP synthesis in mitochondria. Without sufficient NAD+, cells cannot produce energy efficiently.<\/li>\n<li><strong>Sirtuin activation (longevity signaling)<\/strong> \u2014 the seven mammalian sirtuins (SIRT1\u2013SIRT7) are NAD+-dependent deacetylases that regulate gene silencing, stress response, mitochondrial biogenesis, and DNA repair. When NAD+ levels decline, sirtuin activity drops, which is one proposed mechanistic link between NAD+ decline and aging phenotypes (Rajman, Chwalek &amp; Sinclair, Cell Metab 2018).<\/li>\n<li><strong>PARP-mediated DNA repair<\/strong> \u2014 the poly(ADP-ribose) polymerase (PARP) family of enzymes uses NAD+ as substrate for the DNA-damage response. Declining NAD+ levels mean less available substrate for DNA repair, creating a feedback loop where DNA damage further depletes NAD+.<\/li>\n<\/ul>\n<p>Because these three pathways together touch energy metabolism, gene regulation, and genome maintenance, NAD+ restoration is investigated across an unusually broad range of cellular-aging research contexts \u2014 from metabolic syndrome to neurodegeneration to muscle function.<\/p>\n<h2>Published Research Applications<\/h2>\n<p>NAD+ is used in laboratory research contexts that investigate:<\/p>\n<ul>\n<li><strong>Longevity research<\/strong> \u2014 sirtuin-pathway activation and cellular-aging biomarkers in rodent aging studies (Yoshino et al., Cell Metab 2018)<\/li>\n<li><strong>Cellular energy \/ mitochondrial function<\/strong> \u2014 ATP production and mitochondrial biogenesis in cellular-stress research<\/li>\n<li><strong>Neuroprotection research<\/strong> \u2014 cognitive-decline and neurological-aging models in rodent studies<\/li>\n<li><strong>Metabolic health<\/strong> \u2014 insulin sensitivity, glucose homeostasis, and metabolic-syndrome research<\/li>\n<li><strong>DNA repair research<\/strong> \u2014 PARP-pathway activity and genome-maintenance in DNA-damage models<\/li>\n<li><strong>Anti-aging research<\/strong> \u2014 composite cellular-aging markers across multiple tissue systems<\/li>\n<li><strong>Comparative precursor research<\/strong> \u2014 side-by-side with NR (nicotinamide riboside) and NMN (nicotinamide mononucleotide) precursors to isolate the direct-NAD+ effect<\/li>\n<\/ul>\n<p>For broader context on longevity and cellular-aging peptides see <a href=\"https:\/\/medsbase.com\/el\/peptide-stacks-for-fat-loss\/\">peptide stacks for metabolic research<\/a> and the full <a href=\"https:\/\/medsbase.com\/el\/peptides\/\">\u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03c9\u03bd<\/a>.<\/p>\n<h2>\u0394\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b5\u03c2 \u0394\u03c5\u03bd\u03ac\u03bc\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03a3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2<\/h2>\n<p>MedsBase stocks NAD+ in the following lyophilized vial sizes. Each variation ships in 10-vial, 20-vial, or 30-vial pack formats:<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u0394\u03cd\u03bd\u03b1\u03bc\u03b7 \u03a6\u03b9\u03b1\u03bb\u03b9\u03b4\u03af\u03bf\u03c5<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u03a4\u03c5\u03c0\u03b9\u03ba\u03ae \u03a0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03a7\u03c1\u03ae\u03c3\u03b7\u03c2<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u039c\u03b5\u03b3\u03ad\u03b8\u03b7 \u03a3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1\u03c2<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>100\u00a0mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Pilot dosing or short-duration protocols<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10, 20, or 30 vials<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>500\u00a0mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Standard research strength, supports multi-week protocols<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10, 20, or 30 vials<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>1000\u00a0mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Extended research, IV protocols, bulk prep<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10, 20, or 30 vials<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>NAD+ requires larger absolute doses than most peptides (grams rather than micrograms) because it is a coenzyme operating at cellular-pool concentrations, not a signaling molecule operating at receptor-level concentrations. Supplied as lyophilized powder at 99%+ HPLC purity.<\/p>\n<h2>How It Compares \u2014 NAD+ vs NR vs NMN<\/h2>\n<p>Three molecules dominate the NAD+ research space. Each feeds into the same salvage pathway but at different entry points:<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u039a\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03bf<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">NAD+<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">NR (Nicotinamide Riboside)<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">NMN (Nicotinamide Mononucleotide)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u03a1\u03cc\u03bb\u03bf\u03c2<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">End-product coenzyme (direct)<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Precursor (oral)<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Precursor (oral or SC)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Route<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">SC, IM, IV in research<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Oral primarily<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Oral, SC<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Typical research dose<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">50\u20131000\u00a0mg<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">250\u2013500\u00a0mg oral<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">250\u20131000\u00a0mg oral\/SC<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u039a\u03b1\u03b8\u03b5\u03c3\u03c4\u03ce\u03c2 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7\u03c2<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Research use only<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">FDA GRAS dietary supplement<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Variable (recent FDA action)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Researchers typically choose direct NAD+ over precursors when they want to bypass variable enzymatic conversion rates (some precursors convert inefficiently in certain tissues) or when they need rapid plasma elevation. Precursors are preferred in sustained-dosing oral-administration research.<\/p>\n<h2>\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7<\/h2>\n<p><strong>\u03a0\u03c1\u03b9\u03bd \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7:<\/strong> store lyophilized vials refrigerated at 2\u20138\u00a0\u00b0C in original packaging, stable up to 36 months. NAD+ is light-sensitive \u2014 keep original foil packaging intact.<\/p>\n<p><strong>\u0394\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03b1\u03bd\u03b1\u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7\u03c2:<\/strong> inject bacteriostatic water down the side wall of the vial per the chart above. NAD+ vials use larger reconstitution volumes than peptide vials because of the larger absolute dose. Swirl gently \u2014 do <strong>\u03b4\u03b5\u03bd<\/strong> shake \u2014 and allow 5\u201310 minutes for full dissolution.<\/p>\n<p><strong>\u039c\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7:<\/strong> store refrigerated at 2\u20138\u00a0\u00b0C, protected from light, and use within 30 days. Reconstituted NAD+ can degrade more rapidly than peptides \u2014 a yellow-to-brown colour shift indicates oxidation and should trigger discard.<\/p>\n<h2 id=\"faqs\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3>What is NAD+ used for in research?<\/h3>\n<p>NAD+ is used in laboratory research investigating cellular-aging, sirtuin-pathway activation, mitochondrial function, DNA repair via PARP, neuroprotection, and metabolic-health models. It is <strong>\u03b4\u03b5\u03bd<\/strong> FDA-approved for therapeutic use and is sold here strictly for laboratory research use only.<\/p>\n<h3>Is NAD+ a peptide?<\/h3>\n<p>No. NAD+ is a dinucleotide coenzyme, not a peptide. It is commonly supplied through peptide-research suppliers because longevity researchers frequently use it alongside peptide research protocols, and both categories share the lyophilized-powder-with-BAC-water reconstitution format.<\/p>\n<h3>What is the typical NAD+ research dose?<\/h3>\n<p>Published preclinical protocols vary widely by research context. Common ranges: 50\u2013100\u00a0mg SC\/IM daily for longevity research, 250\u2013500\u00a0mg for cellular-energy research, and up to 1,000\u00a0mg in IV research protocols. A 500\u00a0mg vial reconstituted with 5.0\u00a0mL bacteriostatic water yields 100\u00a0mg\/mL \u2014 50 ticks on a U-100 syringe delivers 50\u00a0mg.<\/p>\n<h3>Is NAD+ FDA approved?<\/h3>\n<p>No. NAD+ is not an FDA-approved therapeutic. It has been studied in clinical contexts (including IV &#8220;NAD+ therapy&#8221; wellness clinics) but has not received FDA approval for any specific indication. All NAD+ sold by research-use-only suppliers is for laboratory investigation.<\/p>\n<h3>How is NAD+ different from NR or NMN?<\/h3>\n<p>NR (nicotinamide riboside) and NMN (nicotinamide mononucleotide) are <em>precursors<\/em> that cells convert to NAD+ via the salvage pathway. Direct NAD+ bypasses this conversion step. Researchers choose direct NAD+ when they want to control plasma levels precisely; precursors are used for sustained oral dosing research where enzymatic conversion is acceptable.<\/p>\n<h3>How should NAD+ be stored?<\/h3>\n<p>Lyophilized vials: refrigerated at 2\u20138\u00a0\u00b0C in original packaging, protected from light. Stable up to 36 months. Reconstituted solution: refrigerated at 2\u20138\u00a0\u00b0C, light-protected, use within 30 days. NAD+ is more light- and oxidation-sensitive than most peptides.<\/p>\n<h3>How do I reconstitute NAD+?<\/h3>\n<p>Follow the reconstitution chart above. Add bacteriostatic water down the side wall of the vial, swirl gently, and allow 5\u201310 minutes for full dissolution. NAD+ requires larger reconstitution volumes than peptides because of the larger absolute dose. Do <strong>\u03b4\u03b5\u03bd<\/strong> shake.<\/p>\n<h3>Can NAD+ be stacked with peptides in research?<\/h3>\n<p>Yes. NAD+ is frequently studied alongside <a href=\"https:\/\/medsbase.com\/el\/ghk-cu\/\">GHK-Cu<\/a> (cellular energy research), <a href=\"https:\/\/medsbase.com\/el\/ipamorelin\/\">ipamorelin<\/a> (metabolic-axis research), and other longevity peptides. Because NAD+ operates at the coenzyme level rather than at receptors, pharmacological interactions with peptides are minimal.<\/p>\n<h3>\u03a4\u03bf MedsBase \u03b4\u03b9\u03b1\u03b8\u03ad\u03c4\u03b5\u03b9 retatrutide \u03c3\u03b5 \u03c6\u03b9\u03b1\u03bb\u03af\u03b4\u03b9\u03b1 \u03bb\u03c5\u03bf\u03c6\u03b9\u03bb\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03c3\u03b5 \u03b4\u03c5\u03bd\u03ac\u03bc\u03b5\u03b9\u03c2 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 50 mg \u03ba\u03b1\u03b9 60 mg. \u039a\u03ac\u03b8\u03b5 \u03b4\u03cd\u03bd\u03b1\u03bc\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b7 \u03c3\u03b5 \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b5\u03c2 10 \u03ae 20 \u03c6\u03b9\u03b1\u03bb\u03b9\u03b4\u03af\u03c9\u03bd. \u038c\u03bb\u03b1 \u03c4\u03b1 \u03c6\u03b9\u03b1\u03bb\u03af\u03b4\u03b9\u03b1 \u03c0\u03b1\u03c1\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03ba\u03b1\u03b8\u03b1\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 HPLC 99%+ \u03ba\u03b1\u03b9 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c4\u03cc\u03c0\u03b9\u03bd \u03b1\u03b9\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2.<\/h3>\n<p>MedsBase carries NAD+ in 100\u00a0mg, 500\u00a0mg, and 1000\u00a0mg lyophilized vials. Each strength is available in 10-vial, 20-vial, or 30-vial pack sizes. All vials are supplied at 99%+ HPLC purity with a certificate of analysis on request.<\/p>\n<h3>Does NAD+ cause side effects in research?<\/h3>\n<p>The most commonly reported effect in research and clinical use is a &#8220;flushing&#8221; sensation during IV administration with rapid infusion rates \u2014 believed to be transient vascular effect. Other off-target effects appear minimal at typical research doses. Because NAD+ is an endogenous coenzyme, pharmacological concerns are generally lower than for exogenous xenobiotic compounds.<\/p>\n<h3>What is the biological half-life of NAD+?<\/h3>\n<p>Endogenous NAD+ has a biological half-life of approximately 1\u20132 hours in most cell types, varying significantly by tissue. In preclinical IV administration research, exogenous NAD+ is rapidly taken up by tissues and converted to downstream metabolites (NADH, NAAD, ADPR). The lyophilized form for laboratory reconstitution is typically used in acute supplementation or cell culture research models.<\/p>\n<h3>How does direct NAD+ supplementation compare to NMN and NR in research?<\/h3>\n<p>NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are NAD+ precursors converted to NAD+ intracellularly. Direct NAD+ supplementation is studied for research models where precursor conversion may be rate-limited. All three approaches are active areas of longevity and bioenergetics research, with different bioavailability and metabolic conversion profiles.<\/p>\n<h3>Can I order NAD+ for international shipping?<\/h3>\n<p>Yes. MedsBase ships NAD+ worldwide from our dedicated peptide shipping network. NAD+ orders qualify for our standalone peptide shipping service. Orders ship in temperature-controlled, light-protected packaging with full tracking.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>\u0386\u03bb\u03bb\u03b1 \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03b1\u03bd\u03ac\u03ba\u03b1\u03bc\u03c8\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc\u03b4\u03bf\u03c3\u03b7\u03c2<\/h2>\n<ul>\n<li><a href=\"\/el\/bpc-157\/\"><strong>BPC-157<\/strong><\/a> \u2014 Body Protection Compound \u2014 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03b1\u03bd\u03ac\u03ba\u03b1\u03bc\u03c8\u03b7\u03c2 \u03c4\u03ad\u03bd\u03bf\u03bd\u03c4\u03b1, \u03c3\u03c5\u03bd\u03b4\u03ad\u03c3\u03bc\u03bf\u03c5, \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5<\/li>\n<li><a href=\"\/el\/tb-500\/\"><strong>TB-500<\/strong><\/a> \u2014 \u0398\u03c1\u03b1\u03cd\u03c3\u03bc\u03b1 Thymosin Beta-4 \u2014 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03b1\u03bd\u03ac\u03ba\u03b1\u03bc\u03c8\u03b7\u03c2 \u03bc\u03b1\u03bb\u03b1\u03ba\u03ce\u03bd \u03b9\u03c3\u03c4\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b1\u03b3\u03b3\u03b5\u03af\u03c9\u03bd<\/li>\n<li><a href=\"\/el\/ipamorelin\/\"><strong>\u0399\u03c0\u03b1\u03bc\u03bf\u03c1\u03b5\u03bb\u03af\u03bd\u03b7<\/strong><\/a> \u2014 \u0395\u03c0\u03b9\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ae\u03c2 ghrelin \u2014 \u03ba\u03b1\u03b8\u03b1\u03c1\u03cc\u03c2 \u03c0\u03b1\u03bb\u03bc\u03cc\u03c2 GH \u03c7\u03c9\u03c1\u03af\u03c2 \u03ba\u03bf\u03c1\u03c4\u03b9\u03b6\u03cc\u03bb\u03b7\/\u03c0\u03c1\u03bf\u03bb\u03b1\u03ba\u03c4\u03af\u03bd\u03b7<\/li>\n<li><a href=\"\/el\/cjc-1295-with-dac\/\"><strong>CJC-1295 with DAC<\/strong><\/a> \u2014 \u0391\u03bd\u03b1\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc GHRH \u03bc\u03b5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03bf \u03c7\u03c1\u03cc\u03bd\u03bf \u03b7\u03bc\u03b9\u03b6\u03c9\u03ae\u03c2<\/li>\n<li><a href=\"\/el\/ghk-cu\/\"><strong>GHK-Cu<\/strong><\/a> \u2014 \u03a0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03c7\u03b1\u03bb\u03ba\u03bf\u03cd \u2014 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03b3\u03b9\u03b1 \u03b1\u03bd\u03b1\u03b3\u03ad\u03bd\u03bd\u03b7\u03c3\u03b7 \u03b4\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b4\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03b9\u03c3\u03c4\u03bf\u03cd<\/li>\n<\/ul>\n<p><!-- medsbase-peptide-guide-cta --><\/p>\n<h2>\u03a0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7<\/h2>\n<div style=\"background: #f4f8fb; border-left: 4px solid #2c7cb0; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<p style=\"margin: 0 0 8px 0;\"><strong>\ud83d\udcd6 Learn the research behind this coenzyme<\/strong><\/p>\n<p style=\"margin: 0;\">\u0394\u03b9\u03b1\u03b2\u03ac\u03c3\u03c4\u03b5 \u03c4\u03bf\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03c4\u03b9\u03ba\u03ac \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf \u03bf\u03b4\u03b7\u03b3\u03cc \u03bc\u03b1\u03c2: <a href=\"https:\/\/medsbase.com\/el\/nad-plus-coenzyme-longevity-guide\/\"><strong>NAD+ \u2014 mechanism, longevity research &amp; the honest science<\/strong><\/a>. Covers sirtuin and PARP biology, the NAD+ decline hypothesis, precursor comparison (NR \/ NMN), published research dosing ranges, reconstitution protocols, and safety notes.<\/p>\n<\/div>\n<p><!-- pep-seo-v1 --><\/p>","protected":false},"excerpt":{"rendered":"<p>\u2705 Enhances cellular energy<br \/>\n\u2705 Supports mitochondrial function<br \/>\n\u2705 Promotes metabolic balance<br \/>\n\u2705 Boosts cellular repair<br \/>\n\u2705 Improves vitality pathways<\/p>\n<p><strong>NAD\u207a<\/strong> \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 \u03c3\u03c5\u03bd\u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03b9\u03ba\u03ae \u03ad\u03bd\u03c9\u03c3\u03b7.<\/p>","protected":false},"featured_media":70968,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[5426],"product_tag":[5452,5453],"class_list":{"0":"post-68840","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptides","7":"product_tag-nad","8":"product_tag-nicotinamide-adenine-dinucleotide","10":"first","11":"instock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable","15":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/68840","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=68840"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/70968"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=68840"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=68840"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=68840"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=68840"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}