{"id":68942,"date":"2026-03-03T07:07:09","date_gmt":"2026-03-03T07:07:09","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&#038;p=68942"},"modified":"2026-05-21T07:14:11","modified_gmt":"2026-05-21T07:14:11","slug":"epitalon","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/epitalon\/","title":{"rendered":"\u0395\u03c0\u03b9\u03c4\u03b1\u03bb\u03cc\u03bd"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background: #fff8e1; border-left: 4px solid #f5a623; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<h3 style=\"margin: 0 0 8px 0; font-size: 16px; color: #1a4a6b;\">Quick Answer \u2014 What is Epitalon?<\/h3>\n<p style=\"margin: 0;\"><strong>\u0395\u03c0\u03b9\u03c4\u03b1\u03bb\u03cc\u03bd<\/strong> (Ala-Glu-Asp-Gly, AEDG) is a synthetic tetrapeptide analog of a natural pineal-gland peptide. Central to Vladimir Khavinson&#8217;s Russian longevity-research programme, it is studied for effects on telomere length, circadian rhythm, and gene-expression profiles in aging research. Supplied in 10\u00a0mg and 50\u00a0mg lyophilized vials for laboratory research use only.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background: #f4f8fb; border: 1px solid #d8e3eb; padding: 12px 16px; margin: 16px 0; border-radius: 4px; font-size: 14px;\"><strong>\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong> \u0395\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03bb\u03c5\u03bf\u03c6\u03b9\u03bb\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1 \u00b7 HPLC \u03ba\u03b1\u03b8\u03b1\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u226599% (COA \u03ba\u03b1\u03c4\u03cc\u03c0\u03b9\u03bd \u03b1\u03b9\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2) \u00b7 \u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae \u03c3\u03b5 \u03b8\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03af\u03b1 \u00b7 \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03c9\u03bd \u00b7 1,400+ \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 <a href=\"https:\/\/medsbase.com\/el\/reviews\/\">\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size: 14px; color: #444; margin: 8px 0 18px;\">\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\"><strong>\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n<table class=\"medsbase-spec-table\" style=\"width: 100%; border-collapse: collapse; margin: 18px 0; font-size: 14px;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 8px 12px; text-align: left; width: 30%;\">\u03a0\u03c1\u03bf\u03b4\u03b9\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae<\/th>\n<th style=\"padding: 8px 12px; text-align: left;\">\u039b\u03b5\u03c0\u03c4\u03bf\u03bc\u03ad\u03c1\u03b5\u03b9\u03b1<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u0391\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2 CAS<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">307297-39-8<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u039c\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03a4\u03cd\u03c0\u03bf\u03c2<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">C<sub>14<\/sub>H<sub>22<\/sub>N<sub>4<\/sub>O<sub>9<\/sub><\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u039c\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc \u0392\u03ac\u03c1\u03bf\u03c2<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">390.35 Da<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u0391\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03af\u03b1<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Ala-Glu-Asp-Gly (AEDG)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u039c\u03bf\u03c1\u03c6\u03ae<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u03a5\u03b1\u03bb\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c3\u03ba\u03cc\u03bd\u03b7 (\u03ae \u03cc\u03c0\u03c9\u03c2 \u03c0\u03b1\u03c1\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9)<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u039a\u03b1\u03b8\u03b1\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u226599% (HPLC \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf, COA \u03ba\u03b1\u03c4\u03cc\u03c0\u03b9\u03bd \u03b1\u03b9\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u039b\u03c5\u03bf\u03c6\u03b9\u03bb\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf: 2\u20138 \u00b0C (\u03c8\u03c5\u03b3\u03b5\u03af\u03bf) \u03b3\u03b9\u03b1 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03cc\u03b8\u03b5\u03bc\u03b1\u00b7 \u221220 \u00b0C \u03b3\u03b9\u03b1 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b7 \u03b1\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7 \u03b1\u03bd\u03bf\u03b9\u03c7\u03c4\u03ce\u03bd \u03c6\u03b9\u03b1\u03bb\u03ce\u03bd. \u0391\u03bd\u03b1\u03c3\u03c5\u03bd\u03c4\u03b5\u03b8\u03b5\u03b9\u03bc\u03ad\u03bd\u03bf: 2\u20138 \u00b0C, \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b5\u03bd\u03c4\u03cc\u03c2 ~30 \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd. \u03a0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c3\u03af\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c6\u03c9\u03c2. \u039c\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03c8\u03cd\u03c7\u03b5\u03c4\u03b5-\u03b1\u03c0\u03bf\u03c8\u03cd\u03c7\u03b5\u03c4\u03b5 \u03c4\u03bf \u03b1\u03bd\u03b1\u03c3\u03c5\u03bd\u03c4\u03b5\u03b8\u03b5\u03b9\u03bc\u03ad\u03bd\u03bf \u03b4\u03b9\u03ac\u03bb\u03c5\u03bc\u03b1.<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u0394\u03b9\u03b1\u03bb\u03c5\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u0392\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03bf\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03bd\u03b5\u03c1\u03cc (\u03c0\u03c1\u03bf\u03c4\u03b5\u03af\u03bd\u03b5\u03c4\u03b1\u03b9) \u03ae \u03c3\u03c4\u03b5\u03b9\u03c1\u03c9\u03bc\u03ad\u03bd\u03bf \u03bd\u03b5\u03c1\u03cc \u03b3\u03b9\u03b1 \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03ac \u03b4\u03b9\u03b1\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b7\u03c2<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u0395\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03a7\u03c1\u03ae\u03c3\u03b7<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u039c\u03cc\u03bd\u03bf \u03b3\u03b9\u03b1 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1. \u0394\u03b5\u03bd \u03c0\u03c1\u03bf\u03bf\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 \u03ae \u03b6\u03ce\u03b1.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><!-- \/medsbase-tldr-answer --><\/p>\n<h2>What Is Epitalon?<\/h2>\n<p><strong>\u0395\u03c0\u03b9\u03c4\u03b1\u03bb\u03cc\u03bd<\/strong> (also called <strong>Epithalon<\/strong> \u03ae <strong>AEDG peptide<\/strong>) is a synthetic four-amino-acid peptide: L-Ala-L-Glu-L-Asp-Gly. It is a synthetic analog of a natural pineal-gland peptide called <em>epithalamin<\/em>, isolated from bovine pineal extract and characterised by Vladimir Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology beginning in the 1980s.<\/p>\n<p>Epitalon is one of the most-studied peptides in the Russian longevity-research programme, with published preclinical and small human-cohort research spanning four decades. The research claims \u2014 telomerase activation, chromatin remodeling, lifespan extension in model organisms, normalization of melatonin rhythms in older research subjects \u2014 are substantial but come from a narrow research group; independent Western replication is limited. Molecular weight approximately 390.4\u00a0Da. Supplied as a high-purity lyophilized powder for reconstitution with bacteriostatic water. Epitalon is <strong>\u03bc\u03cc\u03bd\u03bf \u03b3\u03b9\u03b1 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1<\/strong>. For deeper mechanism, Khavinson research context, and honest-science summary, see our <a href=\"https:\/\/medsbase.com\/el\/epitalon-peptide-longevity-guide\/\">Epitalon research guide<\/a>.<\/p>\n<h2>Mechanism of Action \u2014 Telomerase, Pineal Signaling, Gene Expression<\/h2>\n<p>Epitalon&#8217;s proposed mechanisms span multiple biological systems. The research is suggestive rather than conclusive on direct mechanism, but three pathways appear consistently in the published literature:<\/p>\n<ul>\n<li><strong>Telomerase signaling (hypothesized)<\/strong> \u2014 Khavinson&#8217;s research group published multiple reports of telomere-length elongation in lymphocytes and fibroblasts following Epitalon administration, attributed to telomerase activation. Whether Epitalon directly activates telomerase or does so indirectly via gene-expression modulation remains unresolved. Western replication of the telomere observation is limited.<\/li>\n<li><strong>Pineal-gland and melatonin rhythm<\/strong> \u2014 Epitalon is an analog of a pineal-derived peptide and multiple studies describe restoration of age-disrupted melatonin circadian rhythms. The pineal-peptide origin is the mechanistic anchor for sleep-architecture and circadian research context.<\/li>\n<li><strong>Gene expression modulation<\/strong> \u2014 expression profiling studies in Khavinson&#8217;s group describe modulation of approximately 300 rodent genes, with effects on stress-response, antioxidant-defense, and aging-marker pathways. This is the most mechanistically plausible pathway for broader anti-aging research observations.<\/li>\n<\/ul>\n<p>The broader research framework is that pineal-derived peptides regulate age-related system-level biology \u2014 sleep, hormonal rhythm, antioxidant defense \u2014 that collectively influence lifespan. Whether this framework holds up against rigorous Western-standard replication remains an open research question.<\/p>\n<h2>Published Research Applications<\/h2>\n<p>Epitalon is used in laboratory research contexts that investigate:<\/p>\n<ul>\n<li><strong>Telomere-length research<\/strong> \u2014 lymphocyte and fibroblast telomere research in cellular-aging models (Khavinson et al., Neuro Endocrinol Lett 2002; Anisimov et al., Biogerontology 2003)<\/li>\n<li><strong>Aging research<\/strong> \u2014 cellular-aging markers, stress-response, and lifespan in rodent longevity research models<\/li>\n<li><strong>Melatonin and circadian research<\/strong> \u2014 pineal function and sleep-phase research in aging models<\/li>\n<li><strong>Sleep architecture<\/strong> \u2014 slow-wave and REM sleep research in older rodent models<\/li>\n<li><strong>Eye-health research<\/strong> \u2014 retinal and optic-nerve research in age-related degeneration models<\/li>\n<li><strong>NAD+ stacking<\/strong> \u2014 paired with <a href=\"https:\/\/medsbase.com\/el\/nad\/\">NAD+<\/a> in longevity research protocols for complementary cellular-aging pathway coverage<\/li>\n<li><strong>Longevity stacking<\/strong> \u2014 paired with <a href=\"https:\/\/medsbase.com\/el\/semax\/\">Semax<\/a> in cognitive-aging research and with <a href=\"https:\/\/medsbase.com\/el\/ghk-cu\/\">GHK-Cu<\/a> in broader anti-aging research<\/li>\n<\/ul>\n<p>For broader context on longevity peptide research, see the <a href=\"https:\/\/medsbase.com\/el\/peptides\/\">\u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03c9\u03bd<\/a>.<\/p>\n<h2>\u0394\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b5\u03c2 \u0394\u03c5\u03bd\u03ac\u03bc\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03a3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2<\/h2>\n<p>MedsBase stocks Epitalon in the following lyophilized vial sizes:<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u0394\u03cd\u03bd\u03b1\u03bc\u03b7 \u03a6\u03b9\u03b1\u03bb\u03b9\u03b4\u03af\u03bf\u03c5<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u03a4\u03c5\u03c0\u03b9\u03ba\u03ae \u03a0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03a7\u03c1\u03ae\u03c3\u03b7\u03c2<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u039c\u03b5\u03b3\u03ad\u03b8\u03b7 \u03a3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1\u03c2<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>10 mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Standard research strength \u2014 supports a single 10-day cycle at 5 mg + leftover<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10, 20, or 30 vials<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>50 mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Extended research protocols, multiple cycles per vial, lowest per-mg cost<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10, 20, or 30 vials<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Epitalon research protocols typically use cyclical dosing (10\u201320 day active periods 1\u20132 times per year) rather than continuous administration. All strengths are supplied as lyophilized powder at 99%+ HPLC purity.<\/p>\n<h2>How It Compares \u2014 Epitalon vs Other Longevity Peptides<\/h2>\n<p>Epitalon sits within a small longevity-peptide research space. Key comparators:<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u039a\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03bf<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u0395\u03c0\u03b9\u03c4\u03b1\u03bb\u03cc\u03bd<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">NAD+<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">SS-31 (Elamipretide)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Primary mechanism<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Telomerase \/ pineal signaling<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Sirtuin \/ PARP coenzyme<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Mitochondrial cardiolipin binding<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Research-evidence strength<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Narrow group (Khavinson), limited Western replication<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Well-characterised biochemistry, many labs<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Multiple human trials, Szeto-Schiller lab<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u039a\u03b1\u03b8\u03b5\u03c3\u03c4\u03ce\u03c2 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7\u03c2<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Not approved anywhere<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Not approved (IV therapy use common)<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">FDA orphan-drug, Phase 3<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Typical research dose<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">5\u201310 mg SC daily, 10\u201320 day cycles<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">50\u2013100 mg daily<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">5\u201340 mg SC daily<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Researchers often use Epitalon alongside <a href=\"https:\/\/medsbase.com\/el\/nad\/\">NAD+<\/a> \u03ba\u03b1\u03b9 <a href=\"https:\/\/medsbase.com\/el\/ss-31-elamipretide\/\">SS-31 (Elamipretide)<\/a> in multi-pathway longevity research protocols.<\/p>\n<h2>\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7<\/h2>\n<p><strong>\u03a0\u03c1\u03b9\u03bd \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7:<\/strong> store lyophilized vials refrigerated at 2\u20138\u00a0\u00b0C in original packaging, stable up to 36 months. Avoid freeze-thaw cycles on the powder.<\/p>\n<p><strong>\u0394\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03b1\u03bd\u03b1\u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7\u03c2:<\/strong> inject bacteriostatic water down the side wall of the peptide vial per the chart above. Swirl gently \u2014 do <strong>\u03b4\u03b5\u03bd<\/strong> shake \u2014 and allow 5\u201310 minutes for full dissolution. Solution should be clear and colourless.<\/p>\n<p><strong>\u039c\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7:<\/strong> store refrigerated at 2\u20138\u00a0\u00b0C and use within 30 days. Do not freeze reconstituted solution.<\/p>\n<h2 id=\"faqs\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3>What is Epitalon used for in research?<\/h3>\n<p>Epitalon is used in laboratory research investigating telomere-length biology, cellular-aging biomarkers, melatonin and circadian rhythm research, sleep architecture, eye-health research, and multi-pathway longevity research protocols stacked with other compounds. It is <strong>\u03b4\u03b5\u03bd<\/strong> FDA-approved and is sold here strictly for laboratory research use only.<\/p>\n<h3>Does Epitalon really activate telomerase?<\/h3>\n<p>Khavinson&#8217;s Russian research group has published multiple studies reporting telomere-length elongation in lymphocytes and fibroblasts following Epitalon. The proposed mechanism is telomerase activation. Independent Western replication of these telomere observations is limited, so researchers should treat the telomerase-activation claim as a working hypothesis rather than established mechanism.<\/p>\n<h3>What is the typical Epitalon research dose?<\/h3>\n<p>Published preclinical and small-cohort research protocols typically use 5\u201310\u00a0mg SC daily, administered in cyclical 10\u201320 day blocks 1\u20132 times per year rather than continuous administration. A 10\u00a0mg vial reconstituted with 1.0\u00a0mL bacteriostatic water yields 10\u00a0mg\/mL \u2014 50 ticks on a U-100 syringe delivers 5\u00a0mg.<\/p>\n<h3>Is Epitalon FDA approved?<\/h3>\n<p>No. Epitalon has not received FDA, EMA, or any regulatory approval. It is available in Russia as Epithalon \/ Endoluten (a pineal-extract product) but not specifically as the AEDG synthetic peptide. All Epitalon sold by research-use-only suppliers is for laboratory investigation.<\/p>\n<h3>Who is Vladimir Khavinson and why is he cited everywhere?<\/h3>\n<p>Vladimir Khavinson is a Russian researcher at the St. Petersburg Institute of Bioregulation and Gerontology who has led the long-running Epitalon and bioregulatory-peptide research programme. Most of the published Epitalon research originates from his group, which is both the source of deep research history on the compound and the reason independent Western replication is limited.<\/p>\n<h3>How should Epitalon be stored?<\/h3>\n<p>Lyophilized vials: refrigerated at 2\u20138\u00a0\u00b0C in original packaging, stable up to 36 months. Reconstituted solution: refrigerated at 2\u20138\u00a0\u00b0C, use within 30 days. Do not freeze reconstituted solution.<\/p>\n<h3>How do I reconstitute Epitalon?<\/h3>\n<p>Follow the reconstitution chart above. Add bacteriostatic water down the side wall of the vial, swirl gently, and allow 5\u201310 minutes for full dissolution. Do <strong>\u03b4\u03b5\u03bd<\/strong> shake.<\/p>\n<h3>Can Epitalon be stacked with other peptides in research?<\/h3>\n<p>Yes. Epitalon is commonly paired with <a href=\"https:\/\/medsbase.com\/el\/nad\/\">NAD+<\/a>, <a href=\"https:\/\/medsbase.com\/el\/ss-31-elamipretide\/\">SS-31<\/a>, \u03ba\u03b1\u03b9 <a href=\"https:\/\/medsbase.com\/el\/semax\/\">Semax<\/a> in multi-pathway longevity and cognitive-aging research protocols. Each acts via a distinct mechanism, so combined protocols target broader aspects of cellular-aging biology.<\/p>\n<h3>\u03a4\u03bf MedsBase \u03b4\u03b9\u03b1\u03b8\u03ad\u03c4\u03b5\u03b9 retatrutide \u03c3\u03b5 \u03c6\u03b9\u03b1\u03bb\u03af\u03b4\u03b9\u03b1 \u03bb\u03c5\u03bf\u03c6\u03b9\u03bb\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03c3\u03b5 \u03b4\u03c5\u03bd\u03ac\u03bc\u03b5\u03b9\u03c2 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 50 mg \u03ba\u03b1\u03b9 60 mg. \u039a\u03ac\u03b8\u03b5 \u03b4\u03cd\u03bd\u03b1\u03bc\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b7 \u03c3\u03b5 \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b5\u03c2 10 \u03ae 20 \u03c6\u03b9\u03b1\u03bb\u03b9\u03b4\u03af\u03c9\u03bd. \u038c\u03bb\u03b1 \u03c4\u03b1 \u03c6\u03b9\u03b1\u03bb\u03af\u03b4\u03b9\u03b1 \u03c0\u03b1\u03c1\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03ba\u03b1\u03b8\u03b1\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 HPLC 99%+ \u03ba\u03b1\u03b9 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c4\u03cc\u03c0\u03b9\u03bd \u03b1\u03b9\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2.<\/h3>\n<p>MedsBase carries Epitalon in 10\u00a0mg and 50\u00a0mg lyophilized vials. Each strength is available in 10-vial, 20-vial, or 30-vial pack sizes. All vials are supplied at 99%+ HPLC purity with a certificate of analysis on request.<\/p>\n<h3>Does Epitalon cause side effects in research?<\/h3>\n<p>Published research reports a clean safety profile at typical research doses. No significant off-target signals have been identified. Because Epitalon is a small (four amino-acid) peptide with limited systemic exposure, pharmacological concerns are lower than for many peptides \u2014 but long-term human safety data remain limited.<\/p>\n<h3>What is the half-life of Epitalon?<\/h3>\n<p>Epitalon (Ala-Glu-Asp-Gly) is a short tetrapeptide with a rapid plasma half-life estimated at under 30 minutes, consistent with small unmodified peptides. Despite rapid clearance, multiple preclinical and human longevity studies by the original researchers (Khavinson et al.) used intermittent administration cycles \u2014 typically 10\u201320 day courses \u2014 with reported effects on telomerase activity and biomarkers persisting between cycles.<\/p>\n<h3>How does Epitalon activate telomerase in research?<\/h3>\n<p>Epitalon is proposed to stimulate telomerase activity by upregulating hTERT (human telomerase reverse transcriptase) gene expression in somatic cells. In vitro studies and rodent longevity models have shown extended telomere length and increased telomerase activity in treated cells. The mechanism is believed to involve interaction with the pineal gland and downstream neuroendocrine regulation, though direct molecular details remain an active area of research.<\/p>\n<h3>Can I order Epitalon for international shipping?<\/h3>\n<p>Yes. MedsBase ships Epitalon worldwide from our dedicated peptide shipping network. Peptide-only orders qualify for our standalone peptide shipping service. Orders ship in temperature-controlled packaging with full tracking.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>\u0386\u03bb\u03bb\u03b1 \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03b1\u03bd\u03ac\u03ba\u03b1\u03bc\u03c8\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc\u03b4\u03bf\u03c3\u03b7\u03c2<\/h2>\n<ul>\n<li><a href=\"\/el\/bpc-157\/\"><strong>BPC-157<\/strong><\/a> \u2014 Body Protection Compound \u2014 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03b1\u03bd\u03ac\u03ba\u03b1\u03bc\u03c8\u03b7\u03c2 \u03c4\u03ad\u03bd\u03bf\u03bd\u03c4\u03b1, \u03c3\u03c5\u03bd\u03b4\u03ad\u03c3\u03bc\u03bf\u03c5, \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5<\/li>\n<li><a href=\"\/el\/tb-500\/\"><strong>TB-500<\/strong><\/a> \u2014 \u0398\u03c1\u03b1\u03cd\u03c3\u03bc\u03b1 Thymosin Beta-4 \u2014 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03b1\u03bd\u03ac\u03ba\u03b1\u03bc\u03c8\u03b7\u03c2 \u03bc\u03b1\u03bb\u03b1\u03ba\u03ce\u03bd \u03b9\u03c3\u03c4\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b1\u03b3\u03b3\u03b5\u03af\u03c9\u03bd<\/li>\n<li><a href=\"\/el\/ipamorelin\/\"><strong>\u0399\u03c0\u03b1\u03bc\u03bf\u03c1\u03b5\u03bb\u03af\u03bd\u03b7<\/strong><\/a> \u2014 \u0395\u03c0\u03b9\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ae\u03c2 ghrelin \u2014 \u03ba\u03b1\u03b8\u03b1\u03c1\u03cc\u03c2 \u03c0\u03b1\u03bb\u03bc\u03cc\u03c2 GH \u03c7\u03c9\u03c1\u03af\u03c2 \u03ba\u03bf\u03c1\u03c4\u03b9\u03b6\u03cc\u03bb\u03b7\/\u03c0\u03c1\u03bf\u03bb\u03b1\u03ba\u03c4\u03af\u03bd\u03b7<\/li>\n<li><a href=\"\/el\/cjc-1295-with-dac\/\"><strong>CJC-1295 with DAC<\/strong><\/a> \u2014 \u0391\u03bd\u03b1\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc GHRH \u03bc\u03b5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03bf \u03c7\u03c1\u03cc\u03bd\u03bf \u03b7\u03bc\u03b9\u03b6\u03c9\u03ae\u03c2<\/li>\n<li><a href=\"\/el\/ghk-cu\/\"><strong>GHK-Cu<\/strong><\/a> \u2014 \u03a0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03c7\u03b1\u03bb\u03ba\u03bf\u03cd \u2014 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03b3\u03b9\u03b1 \u03b1\u03bd\u03b1\u03b3\u03ad\u03bd\u03bd\u03b7\u03c3\u03b7 \u03b4\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b4\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03b9\u03c3\u03c4\u03bf\u03cd<\/li>\n<\/ul>\n<p><!-- medsbase-peptide-guide-cta --><\/p>\n<h2>\u03a0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7<\/h2>\n<div style=\"background: #f4f8fb; border-left: 4px solid #2c7cb0; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<p style=\"margin: 0 0 8px 0;\"><strong>\ud83d\udcd6 \u039c\u03ac\u03b8\u03b5\u03c4\u03b5 \u03c4\u03b7\u03bd \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03c0\u03af\u03c3\u03c9 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf<\/strong><\/p>\n<p style=\"margin: 0;\">\u0394\u03b9\u03b1\u03b2\u03ac\u03c3\u03c4\u03b5 \u03c4\u03bf\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03c4\u03b9\u03ba\u03ac \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf \u03bf\u03b4\u03b7\u03b3\u03cc \u03bc\u03b1\u03c2: <a href=\"https:\/\/medsbase.com\/el\/epitalon-peptide-longevity-guide\/\"><strong>Epitalon \u2014 telomerase, longevity &amp; the honest science<\/strong><\/a>. Covers pineal-peptide origin, Khavinson&#8217;s research programme, telomere-length research, cyclical dosing protocols, and realistic research expectations.<\/p>\n<\/div>\n<p><!-- pep-seo-v1 --><\/p>","protected":false},"excerpt":{"rendered":"<p>\u2705 Supports cellular longevity<br \/>\n\u2705 Enhances molecular stability<br \/>\n\u2705 Modulates oxidative stress<br \/>\n\u2705 Regulates circadian rhythm<br \/>\n\u2705 Promotes genomic integrity<\/p>\n<p><strong>\u0395\u03c0\u03b9\u03c4\u03b1\u03bb\u03cc\u03bd<\/strong> \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 \u03c3\u03c5\u03bd\u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03b9\u03ba\u03ae \u03ad\u03bd\u03c9\u03c3\u03b7.<\/p>","protected":false},"featured_media":70948,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[5426],"product_tag":[5464,5465],"class_list":{"0":"post-68942","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptides","7":"product_tag-epitalon","8":"product_tag-epithalon","10":"first","11":"instock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable","15":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/68942","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=68942"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/70948"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=68942"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=68942"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=68942"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=68942"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}