{"id":70711,"date":"2026-05-12T09:38:54","date_gmt":"2026-05-12T09:38:54","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&#038;p=70711"},"modified":"2026-05-21T07:14:10","modified_gmt":"2026-05-21T07:14:10","slug":"dsip","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/dsip\/","title":{"rendered":"DSIP"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background: #fff8e1; border-left: 4px solid #f5a623; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<h3 style=\"margin: 0 0 8px 0; font-size: 16px; color: #1a4a6b;\">Quick Answer \u2014 What is DSIP?<\/h3>\n<p style=\"margin: 0;\"><strong>DSIP<\/strong> (Delta Sleep-Inducing Peptide) is a 9-amino-acid neuropeptide first isolated from rabbit cerebral venous blood during electrical stimulation of thalamic sleep-promoting regions in 1977. In published research it modulates sleep architecture \u2014 specifically slow-wave (delta) sleep \u2014 alongside documented effects on stress reactivity, withdrawal syndromes, and nociception. Supplied in 5\u00a0mg to 15\u00a0mg lyophilized vials for laboratory research use only.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background: #f4f8fb; border: 1px solid #d8e3eb; padding: 12px 16px; margin: 16px 0; border-radius: 4px; font-size: 14px;\"><strong>\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong> \u0395\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03bb\u03c5\u03bf\u03c6\u03b9\u03bb\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1 \u00b7 HPLC \u03ba\u03b1\u03b8\u03b1\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u226599% (COA \u03ba\u03b1\u03c4\u03cc\u03c0\u03b9\u03bd \u03b1\u03b9\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2) \u00b7 \u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae \u03c3\u03b5 \u03b8\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03af\u03b1 \u00b7 \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03c9\u03bd \u00b7 1,400+ \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 <a href=\"https:\/\/medsbase.com\/el\/reviews\/\">\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size: 14px; color: #444; margin: 8px 0 18px;\">\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\"><strong>\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n<table class=\"medsbase-spec-table\" style=\"width: 100%; border-collapse: collapse; margin: 18px 0; font-size: 14px;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 8px 12px; text-align: left; width: 30%;\">\u03a0\u03c1\u03bf\u03b4\u03b9\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae<\/th>\n<th style=\"padding: 8px 12px; text-align: left;\">\u039b\u03b5\u03c0\u03c4\u03bf\u03bc\u03ad\u03c1\u03b5\u03b9\u03b1<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u0391\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2 CAS<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">62568-57-4<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u039c\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03a4\u03cd\u03c0\u03bf\u03c2<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">C<sub>35<\/sub>H<sub>48<\/sub>N<sub>10<\/sub>O<sub>15<\/sub><\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u039c\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc \u0392\u03ac\u03c1\u03bf\u03c2<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">848.81 Da<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u0391\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03af\u03b1<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE, 9 amino acids; linear, unmodified termini)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u039c\u03bf\u03c1\u03c6\u03ae<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Lyophilized powder (white to off-white)<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u039a\u03b1\u03b8\u03b1\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u226599% (HPLC \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf, COA \u03ba\u03b1\u03c4\u03cc\u03c0\u03b9\u03bd \u03b1\u03b9\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u039b\u03c5\u03bf\u03c6\u03b9\u03bb\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf: 2\u20138 \u00b0C (\u03c8\u03c5\u03b3\u03b5\u03af\u03bf) \u03b3\u03b9\u03b1 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03cc\u03b8\u03b5\u03bc\u03b1\u00b7 \u221220 \u00b0C \u03b3\u03b9\u03b1 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b7 \u03b1\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7 \u03b1\u03bd\u03bf\u03b9\u03c7\u03c4\u03ce\u03bd \u03c6\u03b9\u03b1\u03bb\u03ce\u03bd. \u0391\u03bd\u03b1\u03c3\u03c5\u03bd\u03c4\u03b5\u03b8\u03b5\u03b9\u03bc\u03ad\u03bd\u03bf: 2\u20138 \u00b0C, \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b5\u03bd\u03c4\u03cc\u03c2 ~30 \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd. \u03a0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c3\u03af\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c6\u03c9\u03c2. \u039c\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03c8\u03cd\u03c7\u03b5\u03c4\u03b5-\u03b1\u03c0\u03bf\u03c8\u03cd\u03c7\u03b5\u03c4\u03b5 \u03c4\u03bf \u03b1\u03bd\u03b1\u03c3\u03c5\u03bd\u03c4\u03b5\u03b8\u03b5\u03b9\u03bc\u03ad\u03bd\u03bf \u03b4\u03b9\u03ac\u03bb\u03c5\u03bc\u03b1.<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u0394\u03b9\u03b1\u03bb\u03c5\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u0392\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03bf\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03bd\u03b5\u03c1\u03cc (\u03c0\u03c1\u03bf\u03c4\u03b5\u03af\u03bd\u03b5\u03c4\u03b1\u03b9) \u03ae \u03c3\u03c4\u03b5\u03b9\u03c1\u03c9\u03bc\u03ad\u03bd\u03bf \u03bd\u03b5\u03c1\u03cc \u03b3\u03b9\u03b1 \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03ac \u03b4\u03b9\u03b1\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b7\u03c2<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u0395\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03a7\u03c1\u03ae\u03c3\u03b7<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u039c\u03cc\u03bd\u03bf \u03b3\u03b9\u03b1 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1. \u0394\u03b5\u03bd \u03c0\u03c1\u03bf\u03bf\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 \u03ae \u03b6\u03ce\u03b1.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><!-- \/medsbase-tldr-answer --><\/p>\n<h2>What Is DSIP?<\/h2>\n<p><strong>DSIP<\/strong> (Delta Sleep-Inducing Peptide) is a 9-amino-acid linear neuropeptide first isolated by Schoenenberger and Monnier at the University of Basel in 1977. The peptide was identified by dialysing cerebral venous blood from rabbits during electrical stimulation of the intralaminar thalamus \u2014 a region known to drive delta-wave (slow-wave) sleep in the cortex \u2014 and concentrating the bioactive fraction. DSIP was named for the dominant electroencephalographic signature it produced when administered to recipient animals: increased proportion of delta-wave activity during sleep.<\/p>\n<p>The well-characterised sequence is WAGGDASGE, molecular weight 848.81\u00a0Da, empirical formula C<sub>35<\/sub>H<sub>48<\/sub>N<sub>10<\/sub>O<sub>15<\/sub>. DSIP is structurally unusual among small CNS-active peptides \u2014 it is linear, unmodified at both termini, and contains no proline or cysteine residues. The peptide is supplied as a high-purity lyophilized powder for reconstitution with bacteriostatic water. DSIP is <strong>not approved<\/strong> by the FDA, EMA, MHRA, or any other major regulator for human therapeutic use. The research-grade DSIP sold here is supplied <strong>\u03bc\u03cc\u03bd\u03bf \u03b3\u03b9\u03b1 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1<\/strong> and is not intended for human or veterinary administration. For related circadian and sleep-axis peptide research, see our <a href=\"https:\/\/medsbase.com\/el\/epitalon\/\">\u0395\u03c0\u03b9\u03c4\u03b1\u03bb\u03cc\u03bd<\/a> \u03ba\u03b1\u03b9 <a href=\"https:\/\/medsbase.com\/el\/selank\/\">Selank<\/a> product pages.<\/p>\n<h2>Mechanism of Action \u2014 Sleep Architecture, Stress Reactivity, and Neuroprotection<\/h2>\n<p>What makes DSIP unusual among research peptides is the breadth of effects documented for such a small, linear peptide without a clearly identified primary receptor. Published research has mapped its activity across <strong>three overlapping domains<\/strong>, each contributing to the observed phenotype:<\/p>\n<ul>\n<li><strong>Sleep architecture modulation \u2014 delta-wave (slow-wave) sleep<\/strong> \u2014 DSIP increases the proportion of slow-wave (stage 3\u20134 \/ N3) sleep on quantitative EEG measurements in rodent, rabbit, and human research without proportionally reducing REM sleep. The effect is most pronounced when DSIP is administered to subjects with fragmented or shortened sleep, suggesting the peptide acts as a homeostatic sleep-pressure modulator rather than a primary sedative. Importantly, DSIP does not directly increase total sleep time in non-sleep-deprived subjects \u2014 it reorganises sleep architecture toward higher SWS proportion.<\/li>\n<li><strong>HPA-axis and stress-reactivity modulation<\/strong> \u2014 Multiple published studies document attenuation of stress-induced cortisol and ACTH release in rodent restraint-stress models, alongside reduction of corticotropin-releasing hormone (CRH) signalling in the hypothalamus. The stress-buffering effect operates on a longer timescale than benzodiazepine sedatives and does not produce acute behavioural sedation, suggesting modulation of HPA-axis tone rather than acute anxiolysis.<\/li>\n<li><strong>Anti-nociception, neuroprotection, and anti-withdrawal<\/strong> \u2014 DSIP shows analgesic effects in rodent thermal and chemical-nociception models, including opioid-naive subjects (suggesting non-opioid mechanism). Russian and Eastern European research has documented attenuation of opioid and alcohol withdrawal syndromes in preclinical models. Neuroprotective effects against oxidative stress, ischaemia, and excitotoxicity have been reported but remain mechanistically less well characterised than the sleep architecture work.<\/li>\n<\/ul>\n<p>The receptor target for DSIP has not been definitively identified, which is unusual for a peptide with this much published behavioural data. Proposed mechanisms include GABA-A modulation, opioid-system crosstalk, and direct interaction with hypothalamic CRH neurons. The lack of an identified primary receptor combined with multiple documented effects suggests DSIP may act as a multimodal neuromodulator rather than a classical receptor agonist \u2014 a hypothesis that remains an active research question in published peptide pharmacology.<\/p>\n<h2>Published Research Applications<\/h2>\n<p>DSIP is used in laboratory research contexts that investigate:<\/p>\n<ul>\n<li><strong>Sleep architecture and EEG research<\/strong> \u2014 quantitative EEG spectral analysis, slow-wave sleep proportion, sleep fragmentation in rodent and human research (Schoenenberger &amp; Monnier, PNAS 1977; Kovalzon &amp; Strekalova, Sleep Med Rev 2006)<\/li>\n<li><strong>Stress reactivity and HPA-axis research<\/strong> \u2014 cortisol and ACTH dynamics, CRH expression, restraint-stress and chronic-mild-stress models in rodents<\/li>\n<li><strong>Withdrawal syndrome research<\/strong> \u2014 opioid withdrawal severity, alcohol withdrawal, benzodiazepine taper; predominantly Russian and Eastern European published literature<\/li>\n<li><strong>Nociception and chronic pain research<\/strong> \u2014 tail-flick, hot-plate, formalin, and chronic-constriction injury models in rodents; non-opioid mechanism characterisation<\/li>\n<li><strong>Neuroprotection research<\/strong> \u2014 oxidative stress markers, ischaemia-reperfusion injury, excitotoxicity models<\/li>\n<li><strong>Circadian biology research<\/strong> \u2014 entrainment, phase-shift response, melatonin and core-temperature rhythm modulation<\/li>\n<li><strong>Comparative sleep-axis peptide research<\/strong> \u2014 benchmarking against <a href=\"https:\/\/medsbase.com\/el\/epitalon\/\">\u0395\u03c0\u03b9\u03c4\u03b1\u03bb\u03cc\u03bd<\/a> (pineal tetrapeptide) for circadian effects and against <a href=\"https:\/\/medsbase.com\/el\/selank\/\">Selank<\/a> for stress-buffering effects without sedation.<\/li>\n<\/ul>\n<p>For broader context on where DSIP fits within the small CNS-active peptide landscape, see <a href=\"https:\/\/medsbase.com\/el\/epitalon\/\">\u0395\u03c0\u03b9\u03c4\u03b1\u03bb\u03cc\u03bd<\/a> (AEDG pineal tetrapeptide, circadian-axis research), <a href=\"https:\/\/medsbase.com\/el\/selank\/\">Selank<\/a> (heptapeptide anxiolytic), and <a href=\"https:\/\/medsbase.com\/el\/semax\/\">Semax<\/a> (heptapeptide nootropic). Browse the full <a href=\"https:\/\/medsbase.com\/el\/peptides\/\">\u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03c9\u03bd<\/a> \u03b3\u03b9\u03b1 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2.<\/p>\n<h2>\u0394\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b5\u03c2 \u0394\u03c5\u03bd\u03ac\u03bc\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03a3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2<\/h2>\n<p>MedsBase stocks DSIP in three lyophilized vial sizes covering pilot dosing through extended research protocols. Each strength is available in 10-vial or 20-vial pack formats with full reconstitution guidance:<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u0394\u03cd\u03bd\u03b1\u03bc\u03b7 \u03a6\u03b9\u03b1\u03bb\u03b9\u03b4\u03af\u03bf\u03c5<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Typical Research Use Case<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u039c\u03b5\u03b3\u03ad\u03b8\u03b7 \u03a3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1\u03c2<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>5 mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Short research protocols, pilot dosing, single-EEG-session research<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10 \u03ae 20 \u03c6\u03b9\u03b1\u03bb\u03af\u03b4\u03b9\u03b1<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>10 mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Standard research strength, multi-week sleep-architecture studies<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10 \u03ae 20 \u03c6\u03b9\u03b1\u03bb\u03af\u03b4\u03b9\u03b1<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>15 mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Extended-cycle protocols, lowest per-mg cost, multi-cohort studies<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10 \u03ae 20 \u03c6\u03b9\u03b1\u03bb\u03af\u03b4\u03b9\u03b1<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>All three strengths are the same chemical form (lyophilized powder, 99%+ HPLC purity). Higher-mg vials require smaller reconstitution volumes per unit dose, which is useful when researchers want to minimise injection volume in rodent protocols or run extended studies from a single vial.<\/p>\n<h2>How It Compares \u2014 DSIP vs Epitalon<\/h2>\n<p>DSIP and <a href=\"https:\/\/medsbase.com\/el\/epitalon\/\">\u0395\u03c0\u03b9\u03c4\u03b1\u03bb\u03cc\u03bd<\/a> are the two most-cited small peptides involved in sleep, circadian, and rest-state research. They share several research-relevant features \u2014 both are short, linear, unmodified peptides without identified primary receptors, and both produce phenotypic effects that outlast plasma clearance \u2014 but their primary research signals are distinct: DSIP modulates sleep architecture directly via SWS proportion; Epitalon acts on the pineal-melatonin axis and circadian gene expression.<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u039a\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03bf<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">DSIP<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u0395\u03c0\u03b9\u03c4\u03b1\u03bb\u03cc\u03bd<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Length<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">9 amino acids (linear)<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">4 amino acids (tetrapeptide)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u0391\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03af\u03b1<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">WAGGDASGE<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">AEDG (Ala-Glu-Asp-Gly)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Primary research signal<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Slow-wave sleep proportion (EEG delta)<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Pineal-melatonin axis, telomerase, circadian gene expression<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Identified receptor<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">None (multimodal neuromodulator)<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">None (gene-regulatory, intracellular)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Typical research dose<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">100\u2013500\u00a0mcg, 1x daily<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">5\u201310\u00a0mg, 1x daily for cycles<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Effect onset<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Same-session (EEG measurable)<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Multi-week (gene-expression timescale)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Stacking<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Co-administered with Epitalon in circadian-sleep stack research<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Co-administered with DSIP for combined sleep+circadian effects<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>For sleep-architecture research, DSIP is the canonical first choice because it produces measurable EEG-level effects on slow-wave sleep proportion within a single sleep session. For circadian-rhythm and gene-regulatory research, Epitalon is preferred because the effect timescale matches the underlying biology (gene expression changes over days to weeks). The two are frequently co-administered when both axes are part of the research question.<\/p>\n<h2>\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7<\/h2>\n<p><strong>\u03a0\u03c1\u03b9\u03bd \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7:<\/strong> store lyophilized vials refrigerated at 2\u20138\u00a0\u00b0C in original packaging for short-term working stock. For unopened long-term storage, freeze at \u221220\u00a0\u00b0C. Lyophilized DSIP is stable under refrigeration for up to 24 months and at \u221220\u00a0\u00b0C for up to 36 months. Avoid freeze-thaw cycles on the lyophilized powder. DSIP is hygroscopic \u2014 reseal vials promptly after opening and store in a desiccated container if available.<\/p>\n<p><strong>\u0394\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03b1\u03bd\u03b1\u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7\u03c2:<\/strong> inject bacteriostatic water down the side wall of the peptide vial (not directly onto the lyophilized cake). For a 5\u00a0mg vial, 2.0\u00a0mL of bacteriostatic water yields a 2.5\u00a0mg\/mL working concentration \u2014 0.04\u00a0mL delivers a 100\u00a0mcg research dose. Swirl gently \u2014 do <strong>\u03b4\u03b5\u03bd<\/strong> shake \u2014 and allow 2\u20135 minutes for full dissolution. A correctly reconstituted solution should be clear and colourless.<\/p>\n<p><strong>\u039c\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7:<\/strong> store refrigerated at 2\u20138\u00a0\u00b0C and use within 30 days for optimal stability. Do not freeze the reconstituted solution \u2014 freeze-thaw cycles degrade peptide integrity. Discard any vial showing cloudiness, precipitate, or discolouration.<\/p>\n<h2 id=\"faqs\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3>What is DSIP used for in research?<\/h3>\n<p>DSIP is used in laboratory research investigating sleep architecture (particularly slow-wave sleep proportion), HPA-axis and stress reactivity, opioid and alcohol withdrawal syndromes, non-opioid analgesia, neuroprotection, and circadian biology. It is the most-cited sleep-axis research peptide that does not act primarily as a sedative \u2014 effects manifest as reorganisation of sleep architecture rather than increased total sleep time. The research-grade DSIP sold here is <strong>\u03b4\u03b5\u03bd<\/strong> FDA-approved and is supplied strictly for laboratory research use only.<\/p>\n<h3>How is DSIP different from Epitalon?<\/h3>\n<p>Both are small unmodified peptides without identified primary receptors that influence rest-state biology, but their primary research signals differ. DSIP modulates sleep architecture at the EEG level \u2014 specifically increasing slow-wave sleep proportion within a single sleep session. Epitalon acts on the pineal-melatonin axis and circadian gene expression on a gene-expression timescale of days to weeks. The two are mechanistically complementary and frequently co-administered in research investigating combined sleep and circadian endpoints.<\/p>\n<h3>What is the typical DSIP research dose?<\/h3>\n<p>Published preclinical protocols typically use 100\u2013500\u00a0mcg per administration in rodent models, given subcutaneously or intraperitoneally once daily for 7\u201328 day cycles. A 5\u00a0mg vial reconstituted with 2.0\u00a0mL bacteriostatic water yields 2.5\u00a0mg\/mL \u2014 0.04\u00a0mL equals 100\u00a0mcg.<\/p>\n<h3>Is DSIP FDA approved?<\/h3>\n<p>No. DSIP is not approved by the FDA, EMA, MHRA, or any other major regulator for human therapeutic use. All DSIP sold by research-use-only suppliers is for laboratory investigation and should not be administered to humans or animals.<\/p>\n<h3>How should DSIP be stored?<\/h3>\n<p>Lyophilized vials: refrigerated at 2\u20138\u00a0\u00b0C for short-term working stock, or \u221220\u00a0\u00b0C for long-term storage of unopened vials. DSIP is hygroscopic \u2014 reseal vials promptly after opening. Reconstituted solution: refrigerated at 2\u20138\u00a0\u00b0C, use within 30 days. Do not freeze reconstituted solution \u2014 freeze-thaw cycles degrade the peptide. Protect from direct light at all times.<\/p>\n<h3>How do I reconstitute DSIP?<\/h3>\n<p>Follow the reconstitution procedure above. Add bacteriostatic water down the side wall of the vial (not onto the lyophilized cake), swirl gently, and allow 2\u20135 minutes for full dissolution. Do <strong>\u03b4\u03b5\u03bd<\/strong> shake the vial. A correctly reconstituted solution is clear and colourless. For a 5\u00a0mg vial + 2.0\u00a0mL diluent, the working concentration is 2.5\u00a0mg\/mL.<\/p>\n<h3>\u03a4\u03bf MedsBase \u03b4\u03b9\u03b1\u03b8\u03ad\u03c4\u03b5\u03b9 retatrutide \u03c3\u03b5 \u03c6\u03b9\u03b1\u03bb\u03af\u03b4\u03b9\u03b1 \u03bb\u03c5\u03bf\u03c6\u03b9\u03bb\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03c3\u03b5 \u03b4\u03c5\u03bd\u03ac\u03bc\u03b5\u03b9\u03c2 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 50 mg \u03ba\u03b1\u03b9 60 mg. \u039a\u03ac\u03b8\u03b5 \u03b4\u03cd\u03bd\u03b1\u03bc\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b7 \u03c3\u03b5 \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b5\u03c2 10 \u03ae 20 \u03c6\u03b9\u03b1\u03bb\u03b9\u03b4\u03af\u03c9\u03bd. \u038c\u03bb\u03b1 \u03c4\u03b1 \u03c6\u03b9\u03b1\u03bb\u03af\u03b4\u03b9\u03b1 \u03c0\u03b1\u03c1\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03ba\u03b1\u03b8\u03b1\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 HPLC 99%+ \u03ba\u03b1\u03b9 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c4\u03cc\u03c0\u03b9\u03bd \u03b1\u03b9\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2.<\/h3>\n<p>MedsBase carries DSIP in 5\u00a0mg, 10\u00a0mg, and 15\u00a0mg lyophilized vials. Each strength is available in 10-vial or 20-vial pack sizes. All vials are supplied at 99%+ HPLC purity with a certificate of analysis available on request.<\/p>\n<h3>Does DSIP cause sedation in research models?<\/h3>\n<p>No \u2014 this is one of the most-cited findings in DSIP research. Unlike benzodiazepines or other classical sedatives, DSIP does not produce acute behavioural sedation, motor coordination loss, or impaired alertness. Instead it modulates sleep architecture toward a higher proportion of slow-wave sleep when the subject does sleep, without increasing total sleep time in non-sleep-deprived subjects. This distinct profile is one of the reasons DSIP has remained a research compound rather than a clinical sedative.<\/p>\n<h3>Can DSIP and Epitalon be stacked in research?<\/h3>\n<p>Yes. DSIP and Epitalon act on different timescales and biological compartments (acute EEG-level sleep architecture vs gene-expression-level circadian regulation), so co-administration is not pharmacologically redundant. Research protocols studying combined sleep-quality and circadian-rhythm endpoints frequently use both peptides.<\/p>\n<h3>Does DSIP cause side effects in research?<\/h3>\n<p>Published preclinical research has reported a notably clean safety profile at typical research doses, with no consistent sedation, motor-coordination effects, dependence liability, or rebound on discontinuation. Long-term human safety data is limited because the peptide has not undergone modern Western regulatory review. The small size and lack of identified primary receptor are consistent with the clean tolerability profile.<\/p>\n<h3>What is the half-life of DSIP?<\/h3>\n<p>In preclinical research, DSIP has a plasma half-life of approximately 7\u201315 minutes following intravenous or subcutaneous administration. The short plasma half-life is offset by the peptide&#8217;s ability to cross the blood-brain barrier and produce effects on sleep architecture and gene expression that persist well beyond plasma clearance.<\/p>\n<h3>Why was DSIP originally isolated?<\/h3>\n<p>DSIP was identified in 1977 by Schoenenberger and Monnier at the University of Basel by dialysing cerebral venous blood from rabbits during electrical stimulation of the intralaminar thalamus \u2014 a brain region known to drive delta-wave (slow-wave) sleep. They concentrated the bioactive fraction and characterised the peptide that produced the strongest sleep-EEG effect when transferred to recipient animals. The peptide was named for its dominant electroencephalographic signature: increased delta-wave activity during sleep.<\/p>\n<h3>How long does DSIP take to show effects in preclinical research?<\/h3>\n<p>Acute effects on sleep architecture and EEG delta-wave proportion are detectable within the first sleep session following administration. HPA-axis and stress-reactivity effects accumulate over 7\u201314 days of regular dosing. Anti-withdrawal effects in opioid and alcohol withdrawal models are typically measured over 3\u20137 day withdrawal periods.<\/p>\n<h3>Can I order DSIP for international shipping?<\/h3>\n<p>Yes. MedsBase ships DSIP worldwide from our dedicated peptide shipping network. Peptide-only orders qualify for our standalone peptide shipping service. All orders ship in temperature-controlled packaging with full tracking and are covered by our <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\">\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/a>.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Other Peptides for Sleep, Circadian, and CNS Research<\/h2>\n<ul>\n<li><a href=\"\/el\/epitalon\/\"><strong>\u0395\u03c0\u03b9\u03c4\u03b1\u03bb\u03cc\u03bd<\/strong><\/a> \u2014 AEDG pineal tetrapeptide \u2014 pineal-melatonin axis and circadian gene-expression research<\/li>\n<li><a href=\"\/el\/selank\/\"><strong>Selank<\/strong><\/a> \u2014 Anxiolytic heptapeptide tuftsin analog \u2014 GABA\/BDNF stress-resilience research<\/li>\n<li><a href=\"\/el\/semax\/\"><strong>Semax<\/strong><\/a> \u2014 Russian-developed nootropic heptapeptide \u2014 melanocortin and dopaminergic modulation<\/li>\n<li><a href=\"\/el\/oxytocin-acetate\/\"><strong>\u039f\u03be\u03c5\u03c4\u03bf\u03ba\u03af\u03bd\u03b7 \u039f\u03be\u03b9\u03ba\u03cc<\/strong><\/a> \u2014 9-aa cyclic nonapeptide \u2014 social-bonding and affiliative behavioural research<\/li>\n<li><a href=\"\/el\/bpc-157\/\"><strong>BPC-157<\/strong><\/a> \u2014 Body Protection Compound \u2014 healing and tissue-recovery research<\/li>\n<\/ul>\n<p><!-- medsbase-peptide-guide-cta --><\/p>\n<h2>\u03a0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7<\/h2>\n<div style=\"background: #f4f8fb; border-left: 4px solid #2c7cb0; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<p style=\"margin: 0 0 8px 0;\"><strong>\ud83d\udcd6 Explore sleep, circadian, and CNS research peptides<\/strong><\/p>\n<p style=\"margin: 0;\">\u03a0\u03b5\u03c1\u03b9\u03b7\u03b3\u03b7\u03b8\u03b5\u03af\u03c4\u03b5 \u03c3\u03b5 \u03bf\u03bb\u03cc\u03ba\u03bb\u03b7\u03c1\u03b7 \u03c4\u03b7\u03bd <a href=\"https:\/\/medsbase.com\/el\/peptides\/\"><strong>\u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03c9\u03bd<\/strong><\/a>, with related compounds including <a href=\"https:\/\/medsbase.com\/el\/epitalon\/\">\u0395\u03c0\u03b9\u03c4\u03b1\u03bb\u03cc\u03bd<\/a> for circadian gene-expression research, <a href=\"https:\/\/medsbase.com\/el\/selank\/\">Selank<\/a> for anxiolytic stress-axis research, and <a href=\"https:\/\/medsbase.com\/el\/oxytocin-acetate\/\">\u039f\u03be\u03c5\u03c4\u03bf\u03ba\u03af\u03bd\u03b7 \u039f\u03be\u03b9\u03ba\u03cc<\/a> for social-bonding behavioural research.<\/p>\n<\/div>\n<p><!-- pep-seo-v1 --><\/p>","protected":false},"excerpt":{"rendered":"<p>\u2705 Delta Sleep-Inducing Peptide (1977 discovery)<br \/>\n\u2705 Modulates slow-wave sleep architecture<br \/>\n\u2705 HPA-axis stress-reactivity research<br \/>\n\u2705 Anti-withdrawal &amp; non-opioid analgesia<br \/>\n\u2705 Crosses the blood-brain barrier<\/p>\n<p><strong>DSIP<\/strong> \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 \u03c3\u03c5\u03bd\u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03b9\u03ba\u03ae \u03ad\u03bd\u03c9\u03c3\u03b7.<\/p>","protected":false},"featured_media":70946,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[5426],"product_tag":[6275,5441],"class_list":{"0":"post-70711","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptides","7":"product_tag-dsip","8":"product_tag-peptide","10":"first","11":"instock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable","15":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/70711","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=70711"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/70946"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=70711"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=70711"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=70711"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=70711"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}