{"id":71466,"date":"2026-05-20T12:20:00","date_gmt":"2026-05-20T12:20:00","guid":{"rendered":"https:\/\/medsbase.com\/b12-cyanocobalamin\/"},"modified":"2026-05-21T07:14:08","modified_gmt":"2026-05-21T07:14:08","slug":"b12-cyanocobalamin","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/b12-cyanocobalamin\/","title":{"rendered":"Vitamin B12 (Cyanocobalamin) Injectable \u2014 Research Grade"},"content":{"rendered":"

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Quick Answer \u2014 What is B12 (Cyanocobalamin) Injectable?<\/h3>\n

\u0392\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7 B12 (Cyanocobalamin)<\/strong> is the synthetic cyano-coordinated form of the cobalamin coenzyme family (CAS 68-19-9, MF C63<\/sub>H88<\/sub>CoN14<\/sub>O14<\/sub>P, MW 1355.37 g\/mol). Supplied here as a 10 mg per 10 mL multi-dose injectable vial<\/strong> (1 mg\/mL pre-formulated sterile aqueous solution \u2014 no reconstitution required) for research and companion-protocol use alongside the peptide catalogue. Cyanocobalamin is the most-cited B12 form in published research because it is the most chemically stable: cells take it up via the transcobalamin-II \/ cubilin pathway and convert it intracellularly to the two biologically-active cobalamin forms \u2014 methylcobalamin<\/strong> (cofactor for methionine synthase \/ SAM cycle \/ one-carbon metabolism) and adenosylcobalamin<\/strong> (cofactor for methylmalonyl-CoA mutase \/ odd-chain fatty acid metabolism \/ TCA entry). For laboratory research use only. Not a peptide<\/em> \u2014 small-molecule cobalt-centered corrinoid coenzyme.<\/p>\n<\/div>\n

\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong> Pre-formulated sterile aqueous solution \u00b7 \u226599% HPLC-verified cyanocobalamin \u00b7 COA available on request \u00b7 Discreet temperature-controlled packaging \u00b7 Worldwide research-supply courier \u00b7 1,400+ verified \u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a><\/div>\n

\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u03a0\u03c1\u03bf\u03b4\u03b9\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae<\/th>\n\u039b\u03b5\u03c0\u03c4\u03bf\u03bc\u03ad\u03c1\u03b5\u03b9\u03b1<\/th>\n<\/tr>\n<\/thead>\n
Compound Class<\/strong><\/td>\nCobalt-centered corrinoid coenzyme; vitamin B12 family; small-molecule cofactor; not a peptide<\/em><\/td>\n<\/tr>\n
Chemical Name<\/strong><\/td>\nCyanocobalamin (synonyms: Vitamin B12, cobalamin (cyano form), CN-B12; the cyano-coordinated synthetic stabilisation form of the cobalamin family)<\/td>\n<\/tr>\n
\u0391\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2 CAS<\/strong><\/td>\n68-19-9 (cyanocobalamin); related cobalamin CAS \u2014 methylcobalamin 13422-55-4, hydroxocobalamin 13422-51-0, adenosylcobalamin 13870-90-1 (not supplied here)<\/td>\n<\/tr>\n
\u039c\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03a4\u03cd\u03c0\u03bf\u03c2<\/strong><\/td>\nC63<\/sub>H88<\/sub>CoN14<\/sub>O14<\/sub>P<\/td>\n<\/tr>\n
\u039c\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc \u0392\u03ac\u03c1\u03bf\u03c2<\/strong><\/td>\n1355.37 g\/mol<\/td>\n<\/tr>\n
Mechanism<\/strong><\/td>\nCyanocobalamin enters cells via the receptor-mediated transcobalamin-II \u2192 cubilin pathway and is converted intracellularly by methionine synthase reductase (MTRR) and methylmalonic aciduria cblA-type protein (MMAA) into the two biologically-active cobalamin coenzymes \u2014 methylcobalamin<\/strong> (cytosolic cofactor for methionine synthase) and adenosylcobalamin<\/strong> (mitochondrial cofactor for methylmalonyl-CoA mutase). Both coenzymes are essential for one-carbon \/ methylation and propionyl-CoA \/ odd-chain fatty acid metabolism respectively.<\/td>\n<\/tr>\n
\u0391\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03af\u03b1<\/strong><\/td>\nn\/a (small-molecule corrinoid coenzyme \u2014 not a peptide)<\/td>\n<\/tr>\n
Form & Concentration<\/strong><\/td>\nPre-formulated sterile aqueous solution<\/strong> \u2014 1 mg\/mL cyanocobalamin in physiological-buffer base, 10 mL multi-dose research vial (10 mg total cyanocobalamin per vial). Characteristic deep red colour from the cobalt-corrin chromophore. No reconstitution required<\/strong> \u2014 withdraw aseptically with sterile syringe.<\/td>\n<\/tr>\n
\u039a\u03b1\u03b8\u03b1\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong><\/td>\n\u226599% (HPLC verified); USP-grade cyanocobalamin reference standard. COA available on request.<\/td>\n<\/tr>\n
\u0394\u03b9\u03b1\u03bb\u03c5\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong><\/td>\nHighly water-soluble (~12.5 mg\/mL solubility limit at 25 \u00b0C); pre-formulated solution is well below saturation. Stable in aqueous buffer at pH 4\u20137. Avoid alkaline conditions (rapid hydroxocobalamin formation) and strong-reducing conditions (cob(II)alamin generation).<\/td>\n<\/tr>\n
\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7<\/strong><\/td>\nRefrigerate at 2\u20138 \u00b0C; protect from light<\/strong> (cyanocobalamin is photosensitive \u2014 UV\/blue light catalyses cyano-to-hydroxo conversion). Use multi-dose vial within 60 days of first puncture. Do not freeze (ice-crystal formation can crack the glass vial and risks photolytic degradation on prolonged frozen storage). Use within stated expiry on the vial label (typically 24 months from manufacture).<\/td>\n<\/tr>\n
\u0395\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03a7\u03c1\u03ae\u03c3\u03b7<\/strong><\/td>\nFor laboratory research use only. Not for human or veterinary diagnostic or therapeutic use. Cyanocobalamin is FDA-approved as an injectable vitamin supplement under the name Cyanokit<\/em> (also for cyanide-poisoning antidote in the hydroxocobalamin form), but the research-grade material supplied here is intended for laboratory use only. Not on the WADA Prohibited List.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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What Is Vitamin B12 (Cyanocobalamin)?<\/h2>\n

Cyanocobalamin<\/strong> (CAS 68-19-9) is the synthetic, cyano-coordinated form of the vitamin B12 family of cobalamin coenzymes. Structurally it is a complex cobalt-centered corrinoid: a 19-atom macrocyclic ring (the corrin ring, similar in geometry to the porphyrin ring of haemoglobin but distinct in composition) coordinates a central cobalt ion in its 3+ oxidation state, with a dimethylbenzimidazole nucleotide tail dangling below the ring and a cyano (-CN) group occupying the upper axial coordination position. Molecular formula C63<\/sub>H88<\/sub>CoN14<\/sub>O14<\/sub>P, molecular weight 1355.37 g\/mol. The molecule is intensely red \u2014 its visible-spectrum absorption (\u03bbmax ~360, ~520, ~550 nm) is what gives B12 solutions their characteristic deep pink-red colour.<\/p>\n

The “cyano” form is a synthetic stabilisation choice rather than a biologically-significant species in vivo. Cobalamins in cells exist primarily as methylcobalamin<\/strong> (a methyl group on the upper axial position \u2014 the cytosolic cofactor for methionine synthase) and adenosylcobalamin<\/strong> (a 5\u2032-deoxyadenosyl group on the upper axial position \u2014 the mitochondrial cofactor for methylmalonyl-CoA mutase). These two active forms are interconverted by dedicated cellular enzymes and are not commercially supplied in stable injectable form because of their light-sensitivity. Cyanocobalamin is supplied instead because the cyano group is photochemically and thermally stable, and cells convert cyanocobalamin to the methyl and adenosyl forms intracellularly via methionine synthase reductase (MTRR) and the methylmalonic aciduria cblA-type protein (MMAA), respectively.<\/p>\n

In the research and clinical context, cyanocobalamin injectable preparations are the canonical supplemental form. The 10 mL multi-dose vial format (1 mg\/mL \u00d7 10 mL = 10 mg per vial) supplied here matches the standard pharmaceutical preparation pattern. MedsBase stocks this format in the peptide-research catalogue as a small-molecule companion compound used in protocols that combine peptide research with cobalamin-axis biology \u2014 recovery research, methylation-cycle research, hematology, cognitive research with nootropic peptides, and energy-metabolism panels where the SAM cycle is engaged.<\/p>\n

Mechanism of Action \u2014 Two Cobalamin-Coenzyme Reactions<\/h2>\n

B12 \/ cyanocobalamin’s biological mechanism is the sum of the two enzymatic reactions catalysed by the active cobalamin coenzymes derived from it:<\/p>\n