{"id":71515,"date":"2026-05-20T10:40:00","date_gmt":"2026-05-20T10:40:00","guid":{"rendered":"https:\/\/medsbase.com\/foxo4-dri\/"},"modified":"2026-05-21T07:14:08","modified_gmt":"2026-05-21T07:14:08","slug":"foxo4-dri","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/foxo4-dri\/","title":{"rendered":"FOXO4-DRI (FOX04-DRI) \u2014 \u03a0\u03b5\u03c0\u03c4\u03b9\u03b4\u03b9\u03ba\u03ae \u0388\u03c1\u03b5\u03c5\u03bd\u03b1 \u03a3\u03b5\u03bd\u03bf\u03bb\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u0394\u03c1\u03ac\u03c3\u03b7\u03c2"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background: #fff8e1; border-left: 4px solid #f5a623; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<h3 style=\"margin: 0 0 8px 0; font-size: 16px; color: #1a4a6b;\">\u0393\u03c1\u03ae\u03b3\u03bf\u03c1\u03b7 \u0391\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u2014 \u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf FOXO4-DRI;<\/h3>\n<p style=\"margin: 0;\"><strong>FOXO4-DRI<\/strong> (\u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ad\u03bd\u03bf FOX04-DRI; \u201cDRI\u201d = D-Retro-Inverso) \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03c3\u03c5\u03bd\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf ~28-\u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03c9\u03bd <strong>\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf senolytic<\/strong> \u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03b3\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 Baar, Brandt, de Keizer, Demaria, Campisi \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03ac\u03c4\u03b5\u03c2 \u03c3\u03c4\u03bf Erasmus University Medical Center, \u03ba\u03b1\u03b9 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03c3\u03c4\u03b7\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae <em>Cell<\/em> \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u201cTargeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging\u201d (Baar et al., March 2017). \u03a4\u03bf \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 D-\u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03bf\u03c2 retro-inverso \u03b5\u03ba\u03b4\u03bf\u03c7\u03ae \u03b5\u03bd\u03cc\u03c2 \u03c4\u03bc\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c4\u03bf\u03c5 transactivation-domain \u03c4\u03bf\u03c5 FOXO4 (\u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af \u03c3\u03c4\u03b1 \u03c5\u03c0\u03bf\u03bb\u03b5\u03af\u03bc\u03bc\u03b1\u03c4\u03b1 ~86\u2013100 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03bf\u03c5 FOXO4). \u0391\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03af\u03b1 \u03bc\u03b5 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03b5\u03b9\u03c1\u03ac \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2: <strong>LTLRKEPASEIAQSILEAYSQNGWANRRSAGGNTPS<\/strong> (\u03cc\u03bb\u03b1 D-\u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03b1, retro-inverso \u03c0\u03c1\u03bf\u03c3\u03b1\u03bd\u03b1\u03c4\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc\u03c2; MW ~3,000 Da). \u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2: \u03a4\u03bf FOXO4 \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03ac \u03b4\u03ad\u03bd\u03b5\u03b9 \u03c4\u03bf p53 \u03c3\u03c4\u03bf\u03bd \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1 \u03c4\u03c9\u03bd \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03bf\u03bd\u03c4\u03ac\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c6\u03b5\u03cd\u03b3\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c0\u03b1\u03c1\u03ac \u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03ae \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7 p53. \u03a4\u03bf FOXO4-DRI \u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03b5\u03b9 \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf transactivation-domain \u03c4\u03bf\u03c5 p53, \u03b5\u03ba\u03c4\u03bf\u03c0\u03af\u03b6\u03b5\u03b9 \u03c4\u03bf \u03b5\u03b3\u03b3\u03b5\u03bd\u03ad\u03c2 FOXO4, \u03ba\u03b1\u03b9 \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03b5\u03c1\u03ce\u03bd\u03b5\u03b9 \u03c4\u03bf p53 \u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03c4\u03bf\u03c0\u03b9\u03c3\u03c4\u03b5\u03af \u03c3\u03c4\u03b1 \u03bc\u03b9\u03c4\u03bf\u03c7\u03cc\u03bd\u03b4\u03c1\u03b9\u03b1 \u2014 \u03c0\u03c5\u03c1\u03bf\u03b4\u03bf\u03c4\u03ce\u03bd\u03c4\u03b1\u03c2 \u03b5\u03c0\u03b9\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae <strong>senolysis<\/strong> (\u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 \u03bc\u03cc\u03bd\u03bf \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd). \u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03ac\u03c3\u03ba\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7\u03c2. \u039c\u03cc\u03bd\u03bf \u03b3\u03b9\u03b1 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background: #f4f8fb; border: 1px solid #d8e3eb; padding: 12px 16px; margin: 16px 0; border-radius: 4px; font-size: 14px;\"><strong>\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong> \u039b\u03c5\u03bf\u03c6\u03b9\u03bb\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u226599% HPLC-\u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf FOXO4-DRI \u00b7 COA \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03bf \u03ba\u03b1\u03c4\u03cc\u03c0\u03b9\u03bd \u03b1\u03b9\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u00b7 \u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae \u03c3\u03b5 \u03b8\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03af\u03b1 \u00b7 \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u03b3\u03b9\u03b1 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03bf\u03bc\u03ae\u03b8\u03b5\u03b9\u03b5\u03c2 \u00b7 1,400+ \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 <a href=\"https:\/\/medsbase.com\/el\/reviews\/\">\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size: 14px; color: #444; margin: 8px 0 18px;\">\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\"><strong>\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n<table class=\"medsbase-spec-table\" style=\"width: 100%; border-collapse: collapse; margin: 18px 0; font-size: 14px;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 8px 12px;\">\u03a0\u03c1\u03bf\u03b4\u03b9\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae<\/th>\n<th style=\"padding: 8px 12px;\">\u039b\u03b5\u03c0\u03c4\u03bf\u03bc\u03ad\u03c1\u03b5\u03b9\u03b1<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\"><strong>\u039a\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u0395\u03bd\u03ce\u03c3\u03b5\u03c9\u03c2<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u03a3\u03c5\u03bd\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf ~28-aa D-\u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03c9\u03bd retro-inverso\u00b7 senolytic \u03ad\u03bd\u03c9\u03c3\u03b7\u00b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1\u03c2 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd p53-FOXO4<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\"><strong>\u03a7\u03b7\u03bc\u03b9\u03ba\u03ae \u039f\u03bd\u03bf\u03bc\u03b1\u03c3\u03af\u03b1<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">FOXO4-DRI (\u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03c1\u03b8\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b5\u03c2: FOX04-DRI; FOXO4-D-Retro-Inverso; \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf senolytic Baar\/Demaria\/de Keizer; ProxoFen \u2014 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf \u03c0\u03c1\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03cc\u03bd\u03bf\u03bc\u03b1)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\"><strong>\u0391\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2 CAS<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u03a0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u2014 \u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b5\u03c5\u03c1\u03ad\u03c9\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03bf \u03bc\u03bf\u03bd\u03b1\u03b4\u03b9\u03ba\u03cc CAS\u00b7 \u03b1\u03bd\u03b1\u03b3\u03bd\u03ce\u03c1\u03b9\u03c3\u03b7 \u03bc\u03ad\u03c3\u03c9 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03af\u03b1\u03c2 (Baar et al. 2017) \u03ba\u03b1\u03b9 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7\u03c2 \u03c0\u03c1\u03bf\u03bc\u03b7\u03b8\u03b5\u03c5\u03c4\u03ae (COA)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\"><strong>\u0391\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03af\u03b1 (\u03c0\u03c1\u03bf\u03ce\u03b8\u03b7\u03c3\u03b7 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2)<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">LTLRKEPASEIAQSILEAYSQNGWANRRSAGGNTPS (\u03c0\u03c1\u03bf\u03ce\u03b8\u03b7\u03c3\u03b7 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2\u00b7 \u03cc\u03bb\u03b1 \u03c4\u03b1 28 \u03c5\u03c0\u03bf\u03bb\u03b5\u03af\u03bc\u03bc\u03b1\u03c4\u03b1 \u03c3\u03b5 <strong>D-\u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03b9\u03ba\u03ae \u03c3\u03c4\u03b5\u03c1\u03b5\u03bf\u03c7\u03b7\u03bc\u03b5\u03af\u03b1<\/strong>, \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b1 \u03c0\u03af\u03c3\u03c9-\u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03c1\u03bf\u03c6\u03b7 \u03c0\u03c1\u03bf\u03c3\u03b1\u03bd\u03b1\u03c4\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03b3\u03b3\u03b5\u03bd\u03ae \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03af\u03b1 L-FOXO4). \u039f\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03b5\u03bb\u03b1\u03c6\u03c1\u03ce\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc \u03bc\u03ae\u03ba\u03bf\u03c2 \u03b8\u03c1\u03b1\u03cd\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2\/\u03b5\u03cd\u03c1\u03bf\u03c2 \u03c5\u03c0\u03bf\u03bb\u03b5\u03b9\u03bc\u03bc\u03ac\u03c4\u03c9\u03bd\u00b7 \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf COA \u03b3\u03b9\u03b1 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03af\u03b1 \u03c0\u03b1\u03c1\u03c4\u03af\u03b4\u03b1\u03c2.<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\"><strong>\u039c\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc \u0392\u03ac\u03c1\u03bf\u03c2<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">~3.000 Da (\u03c0\u03bf\u03b9\u03ba\u03af\u03bb\u03bb\u03b5\u03b9 \u03b5\u03bb\u03b1\u03c6\u03c1\u03ce\u03c2 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03af\u03b1\u03c2)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u039c\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03a4\u03cd\u03c0\u03bf\u03c2<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">D-retro-inverso \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u2014 \u03ba\u03b1\u03c4\u03ac \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c2 (MF) C<sub>105<\/sub>H<sub>184<\/sub>N<sub>30<\/sub>O<sub>27<\/sub>; \u00b7 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc \u03b2\u03ac\u03c1\u03bf\u03c2 (MW) ~2.330 Da. \u039f \u03b1\u03ba\u03c1\u03b9\u03b2\u03ae\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c2 \u03c0\u03bf\u03b9\u03ba\u03af\u03bb\u03bb\u03b5\u03b9 \u03b5\u03bb\u03b1\u03c6\u03c1\u03ce\u03c2 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c0\u03b1\u03c1\u03c4\u03af\u03b4\u03c9\u03bd \u03c0\u03c1\u03bf\u03bc\u03b7\u03b8\u03b5\u03c5\u03c4\u03ce\u03bd, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03b7 \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03ae \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03af\u03b1 Baar 2017 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03bd\u03b1\u03c0\u03b1\u03c1\u03b1\u03c7\u03b8\u03b5\u03af \u03b1\u03c0\u03cc \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03bc\u03b5 \u03b5\u03bb\u03b1\u03c6\u03c1\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c3\u03c5\u03bd\u03b4\u03ad\u03c3\u03bc\u03bf\u03c5 \u03b4\u03b9\u03b5\u03b9\u03c3\u03b4\u03c5\u03c4\u03b9\u03ba\u03bf\u03cd \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03bf\u03c5.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\"><strong>\u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u03a3\u03b5 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03b7 \u03b5\u03b3\u03b3\u03b5\u03bd\u03ae\u03c2 FOXO4 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c4\u03bf\u03bc\u03ad\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03ae\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 p53 \u03ba\u03b1\u03b9 \u03b1\u03b3\u03ba\u03c5\u03c1\u03ce\u03bd\u03b5\u03b9 \u03c4\u03bf p53 \u03c3\u03c4\u03bf\u03bd \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1 \u2014 \u03b1\u03c0\u03bf\u03c4\u03c1\u03ad\u03c0\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf p53 \u03b1\u03c0\u03cc \u03c4\u03bf \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03b5\u03b9 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c0\u03b1\u03c1\u03ac \u03c4\u03b7 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b2\u03bb\u03ac\u03b2\u03b7 \u03c0\u03bf\u03c5 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b5 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03c4\u03bf p53. \u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03ad\u03c1\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03bb\u03cc\u03b3\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03c4\u03b1 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b5\u03c0\u03b9\u03b2\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c5\u03c3\u03c3\u03c9\u03c1\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7. <strong>FOXO4-DRI<\/strong> \u03bc\u03b9\u03bc\u03b5\u03af\u03c4\u03b1\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03b5\u03c0\u03b1\u03c6\u03ae \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7\u03c2 FOXO4 \u03bc\u03b5 \u03c4\u03bf p53 \u03b1\u03bb\u03bb\u03ac \u03c3\u03b5 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03c1\u03bf\u03c6\u03b7-\u03c3\u03c4\u03b5\u03c1\u03b5\u03bf\u03c7\u03b7\u03bc\u03b5\u03af\u03b1 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b1 \u03c0\u03af\u03c3\u03c9-\u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03c1\u03bf\u03c6\u03b7 \u03c0\u03c1\u03bf\u03c3\u03b1\u03bd\u03b1\u03c4\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc \u2014 \u03ba\u03b1\u03c4\u03b1\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03bd \u03c4\u03cc\u03c0\u03bf \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7\u03c2 p53, \u03b5\u03ba\u03c4\u03bf\u03c0\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03b3\u03b3\u03b5\u03bd\u03ae FOXO4 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03b5\u03c1\u03ce\u03bd\u03b5\u03b9 \u03c4\u03bf p53. \u03a4\u03bf \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03b5\u03c1\u03c9\u03bc\u03ad\u03bd\u03bf p53 \u03bc\u03b5\u03c4\u03b1\u03c4\u03bf\u03c0\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03bc\u03b9\u03c4\u03bf\u03c7\u03cc\u03bd\u03b4\u03c1\u03b9\u03b1 \u03cc\u03c0\u03bf\u03c5 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af <strong>\u03b5\u03bd\u03b4\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7<\/strong> \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 p53-\u03bc\u03b5\u03c3\u03bf\u03bb\u03b1\u03b2\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7\u03c2 Bax \/ Bak \/ \u03ba\u03c5\u03c4\u03bf\u03c7\u03c1\u03c9\u03bc\u03af\u03bf\u03c5-c-\u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c1\u03c1\u03ac\u03ba\u03c4\u03b7. \u0395\u03c0\u03b9\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03b3\u03b9\u03b1 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03ad\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b4\u03cd\u03bf (\u03b1) FOXO4-\u03b4\u03b5\u03c3\u03bc\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf p53 \u03ba\u03b1\u03b9 (\u03b2) \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf p53 \u03ae\u03b4\u03b7\u00b7 \u03c4\u03b1 \u03bc\u03b7 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03bd\u03ad\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9.<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\"><strong>\u03a3\u03c4\u03b5\u03c1\u03b5\u03bf\u03c7\u03b7\u03bc\u03b5\u03af\u03b1 D-\u0391\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03c9\u03bd<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u039f \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03cc\u03c2 D-\u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03c9\u03bd retro-inverso \u03c0\u03c1\u03bf\u03c3\u03b4\u03af\u03b4\u03b5\u03b9 \u03b1\u03bd\u03c4\u03bf\u03c7\u03ae \u03c3\u03c4\u03b9\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ac\u03c3\u03b5\u03c2 \u2014 \u03bf\u03b9 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ac\u03c3\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03be\u03b5\u03bd\u03b9\u03c3\u03c4\u03ae \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03bc\u03cc\u03bd\u03bf L-\u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03b1 \u2014 \u03b5\u03c0\u03b5\u03ba\u03c4\u03b5\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf\u03bd \u03c7\u03c1\u03cc\u03bd\u03bf \u03b7\u03bc\u03b9\u03b6\u03c9\u03ae\u03c2 in-vivo \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c4\u03cc\u03bc\u03b1 \/ \u03b5\u03bd\u03b4\u03bf\u03c0\u03b5\u03c1\u03b9\u03c4\u03bf\u03bd\u03b1\u03ca\u03ba\u03ac \u03c3\u03b5 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03c1\u03c9\u03c4\u03bf\u03ba\u03cc\u03bb\u03bb\u03bf\u03c5\u03c2 \u03c4\u03c1\u03c9\u03ba\u03c4\u03b9\u03ba\u03ce\u03bd.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\"><strong>\u0394\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 In-Vivo \u0395\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 (Baar 2017)<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u0395\u03c0\u03b9\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03bc\u03ac\u03ba\u03c1\u03c5\u03bd\u03c3\u03b7 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b1\u03c0\u03cc \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1\u00b7 \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03c5\u03ba\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03c4\u03c1\u03b9\u03c7\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2\u00b7 \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 \/ \u03b1\u03bd\u03c4\u03bf\u03c7\u03ae\u03c2 \u03c3\u03c4\u03b7\u03bd \u03c4\u03c1\u03ad\u03be\u03b9\u03bc\u03bf\u00b7 \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b2\u03b9\u03bf\u03b4\u03b5\u03b9\u03ba\u03c4\u03ce\u03bd \u03c4\u03b7\u03c2 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2\u00b7 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c3\u03b5 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03b2\u03bb\u03ac\u03b2\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7 \u03bc\u03b5 DOX. \u03a4\u03bf \u03ac\u03c1\u03b8\u03c1\u03bf \u03c0\u03b1\u03c1\u03ae\u03b3\u03b1\u03b3\u03b5 \u03bc\u03b9\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c0\u03b9\u03bf \u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03b1\u03c0\u03bf\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03cc\u03c4\u03b9 \u03b7 \u03b1\u03c0\u03bf\u03bc\u03ac\u03ba\u03c1\u03c5\u03bd\u03c3\u03b7 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bd\u03b1\u03b6\u03c9\u03bf\u03b3\u03bf\u03bd\u03ae\u03c3\u03b5\u03b9 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ac \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2.<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\"><strong>\u039c\u03bf\u03c1\u03c6\u03ae \/ \u039a\u03b1\u03b8\u03b1\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \/ \u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u039b\u03c5\u03bf\u03c6\u03b9\u03bb\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03c3\u03ba\u03cc\u03bd\u03b7 \u03bb\u03b5\u03c5\u03ba\u03bf\u03cd \u03ad\u03c9\u03c2 \u03b1\u03bd\u03bf\u03b9\u03ba\u03c4\u03bf\u03cd \u03bb\u03b5\u03c5\u03ba\u03bf\u03cd \u03c7\u03c1\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2, \u226599% HPLC. \u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7 2\u20138 \u00b0C \u03b2\u03c1\u03b1\u03c7\u03c5\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b1, \u221220 \u00b0C \u03bc\u03b1\u03ba\u03c1\u03bf\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b1. \u0391\u03bd\u03b1\u03c3\u03c5\u03bd\u03c4\u03b9\u03b8\u03ad\u03bc\u03b5\u03bd\u03bf: 2\u20138 \u00b0C, \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b5\u03bd\u03c4\u03cc\u03c2 30 \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd. \u0391\u03c0\u03bf\u03c6\u03cd\u03b3\u03b5\u03c4\u03b5 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03ac\u03c8\u03c5\u03be\u03b7-\u03b1\u03c0\u03cc\u03c8\u03c5\u03be\u03b7.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\"><strong>\u0395\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03a7\u03c1\u03ae\u03c3\u03b7<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u0393\u03b9\u03b1 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03c7\u03c1\u03ae\u03c3\u03b7 \u03bc\u03cc\u03bd\u03bf. \u0394\u03b5\u03bd \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u039a\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf \u0391\u03c0\u03b1\u03b3\u03bf\u03c1\u03b5\u03c5\u03bc\u03ad\u03bd\u03c9\u03bd \u039f\u03c5\u03c3\u03b9\u03ce\u03bd \u03c4\u03b7\u03c2 WADA. \u03a0\u03c1\u03cc\u03b4\u03c1\u03bf\u03bc\u03b7 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03ad\u03bd\u03c9\u03c3\u03b7. \u039a\u03b1\u03bc\u03af\u03b1 \u03b5\u03c0\u03af\u03c3\u03b7\u03bc\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03af\u03b4\u03b9\u03bf \u03c4\u03bf FOXO4-DRI\u00b7 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c3\u03b5\u03bd\u03cc\u03bb\u03c5\u03c4\u03b9\u03ba\u03b5\u03c2 \u03b5\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2 (dasatinib + quercetin, fisetin, navitoclax) \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03bf-\u03bc\u03b5\u03c4\u03b1\u03c6\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03be\u03b5\u03c7\u03c9\u03c1\u03b9\u03c3\u03c4\u03ac.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><!-- \/medsbase-tldr-answer --><\/p>\n<h2>\u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u0394\u03c1\u03ac\u03c3\u03b7\u03c2 \u2014 \u0395\u03c0\u03b9\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03a3\u03b5\u03bd\u03cc\u03bb\u03c5\u03c3\u03b7 \u03bc\u03ad\u03c3\u03c9 \u0394\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae\u03c2 p53-FOXO4<\/h2>\n<p>\u03a4\u03bf FOXO4-DRI \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03cc \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1 \u03b5\u03c1\u03b3\u03b1\u03bb\u03b5\u03af\u03bf\u03c5 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1\u03c2 \u03c4\u03b7\u03c2 <strong>\u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u03b2\u03b1\u03c3\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c3\u03b5 \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1 \u03c3\u03b5\u03bd\u03cc\u03bb\u03c5\u03c3\u03b7\u03c2<\/strong>. \u0397 \u03ad\u03bd\u03bd\u03bf\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03c3\u03b5\u03bd\u03cc\u03bb\u03c5\u03c3\u03b7\u03c2 (\u03b5\u03c0\u03b9\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03b8\u03b1\u03bd\u03ac\u03c4\u03c9\u03c3\u03b7 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1) \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03b9\u03bf \u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03cc\u03bc\u03b5\u03bd\u03b1 \u03c4\u03c1\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1 \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ac \u03bc\u03ad\u03c4\u03c1\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03c2 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7\u03c2. \u0397 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b9\u03c3\u03c4\u03bf\u03c1\u03af\u03b1 \u03c4\u03bf\u03c5 FOXO4-DRI \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c3\u03c5\u03bd\u03ae\u03b8\u03b9\u03c3\u03c4\u03b1 \u03ba\u03b1\u03b8\u03b1\u03c1\u03ae:<\/p>\n<ul>\n<li><strong>\u03a4\u03b1 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03c5\u03c3\u03c3\u03c9\u03c1\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7<\/strong> \u2014 \u0397 \u03b2\u03bb\u03ac\u03b2\u03b7 \u03b9\u03c3\u03c4\u03bf\u03cd, \u03b7 \u03b2\u03bb\u03ac\u03b2\u03b7 DNA, \u03c4\u03bf \u03bf\u03be\u03b5\u03b9\u03b4\u03c9\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03c1\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03bf\u03b9 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c3\u03c4\u03c1\u03b5\u03c2 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd \u03c3\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03b7\u03bd \u03b5\u03af\u03c3\u03bf\u03b4\u03bf \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7\u03c2 (\u03bc\u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03ad\u03c8\u03b9\u03bc\u03b7 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03c4\u03bf\u03c5 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03bf\u03cd \u03ba\u03cd\u03ba\u03bb\u03bf\u03c5 \u03bc\u03b5 \u03b5\u03c0\u03af\u03bc\u03bf\u03bd\u03b7 SASP \u2014 \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf \u03b5\u03ba\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03c6\u03bf\u03c1\u03ac\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7). \u03a4\u03b1 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03c5\u03c3\u03c3\u03c9\u03c1\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7 \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b9\u03c3\u03c4\u03bf\u03cd \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1. \u0397 \u03b5\u03c0\u03b9\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03bc\u03ac\u03ba\u03c1\u03c5\u03bd\u03c3\u03b7 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03c1\u03ad\u03c6\u03b5\u03b9 \u03c0\u03bf\u03bb\u03bb\u03ac \u03b7\u03bb\u03b9\u03ba\u03b9\u03b1\u03ba\u03ac \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03b1 \u03c3\u03b5 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03c0\u03bf\u03bd\u03c4\u03b9\u03ba\u03b9\u03ce\u03bd.<\/li>\n<li><strong>\u03a4\u03bf FOXO4 \u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03b5\u03b9 \u03c4\u03bf p53 \u03c3\u03b5 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1<\/strong> \u2014 \u03a4\u03b1 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 p53 \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b5\u03c1\u03b3\u03cc \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7 p53. \u039a\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03ac, \u03c4\u03bf p53 \u03b8\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03c3\u03b5 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7. \u0391\u03bb\u03bb\u03ac \u03c3\u03b5 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03bf \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03cc\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 FOXO4 \u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03b5\u03b9 \u03c4\u03bf p53 \u03c3\u03c4\u03bf\u03bd \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1, \u03ba\u03c1\u03b1\u03c4\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf \u03b5\u03ba\u03b5\u03af \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03c1\u03ad\u03c0\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac\u03b2\u03b1\u03c3\u03ae \u03c4\u03bf\u03c5 \u03c3\u03c4\u03b1 \u03bc\u03b9\u03c4\u03bf\u03c7\u03cc\u03bd\u03b4\u03c1\u03b9\u03b1 \u03cc\u03c0\u03bf\u03c5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03b8\u03b1 \u03be\u03b5\u03ba\u03b9\u03bd\u03bf\u03cd\u03c3\u03b5 \u03c4\u03bf\u03bd \u03b5\u03bd\u03b4\u03bf\u03b3\u03b5\u03bd\u03ae \u03ba\u03b1\u03c4\u03b1\u03c1\u03c1\u03ac\u03ba\u03c4\u03b7 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7\u03c2. \u0391\u03c5\u03c4\u03ae \u03b7 \u03b4\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7 FOXO4-p53 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03ad\u03c1\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c3\u03c4\u03b1 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bd\u03b1 \u03b5\u03c0\u03b9\u03b2\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd.<\/li>\n<li><strong>\u03a4\u03bf FOXO4-DRI \u03c9\u03c2 \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ae\u03c2 \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03bf\u03bc\u03b9\u03bc\u03b7\u03c4\u03b9\u03ba\u03cc\u03c2<\/strong> \u2014 \u03a4\u03bf \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03c3\u03c7\u03b5\u03b4\u03b9\u03ac\u03c3\u03c4\u03b7\u03ba\u03b5 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03bc\u03b9\u03bc\u03b7\u03b8\u03b5\u03af \u03c4\u03b7 \u03b4\u03b9\u03b5\u03c0\u03b1\u03c6\u03ae \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7\u03c2 FOXO4 \u03bc\u03b5 \u03c4\u03bf p53, \u03b1\u03bb\u03bb\u03ac \u03c3\u03b5 \u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03b1\u03bc\u03bc\u03ad\u03bd\u03b7 \u03c0\u03c1\u03bf\u03c3\u03b1\u03bd\u03b1\u03c4\u03bf\u03bb\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03c3\u03b5 D-\u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03b1. \u03a3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf p53 \u03bc\u03b5 \u03c3\u03c5\u03b3\u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03b7 \u03c3\u03c5\u03b3\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ae FOXO4 \u2014 \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03b8\u03ad\u03c3\u03b7 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7\u03c2. \u0397 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 FOXO4-DRI \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03b5\u03ba\u03c4\u03bf\u03c0\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ae FOXO4 \u03b1\u03c0\u03cc \u03c4\u03bf p53 \u03c3\u03b5 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1.<\/li>\n<li><strong>\u03a4\u03bf \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03b5\u03c1\u03c9\u03bc\u03ad\u03bd\u03bf p53 \u2192 \u03bc\u03b9\u03c4\u03bf\u03c7\u03bf\u03bd\u03b4\u03c1\u03b9\u03b1\u03ba\u03ae \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7<\/strong> \u2014 \u03a4\u03bf \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03bf p53 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bb\u03ad\u03bf\u03bd \u03b4\u03b5\u03c3\u03bc\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03c3\u03c4\u03bf\u03bd \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03c4\u03bf\u03c0\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03bc\u03b9\u03c4\u03bf\u03c7\u03cc\u03bd\u03b4\u03c1\u03b9\u03b1. \u0395\u03ba\u03b5\u03af \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7\u03bd \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03ae p53-\u03bc\u03b5\u03c3\u03bf\u03bb\u03b1\u03b2\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03bc\u03b9\u03c4\u03bf\u03c7\u03bf\u03bd\u03b4\u03c1\u03b9\u03b1\u03ba\u03ae \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 (\u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 Bax\/Bak, \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03c3\u03b7 \u03ba\u03c5\u03c4\u03bf\u03c7\u03c1\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2-c, \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 APAF-1 \/ \u03ba\u03b1\u03c3\u03c0\u03ac\u03c3\u03b7-9 \/ \u03ba\u03b1\u03c3\u03c0\u03ac\u03c3\u03b7-3). \u03a4\u03bf \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf \u03c5\u03c6\u03af\u03c3\u03c4\u03b1\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7.<\/li>\n<li><strong>\u0395\u03c0\u03b9\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b3\u03b9\u03b1 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1<\/strong> \u2014 \u03a4\u03b1 \u03bc\u03b7 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b5\u03af\u03c4\u03b5 \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf p53 (\u03bf\u03c0\u03cc\u03c4\u03b5 \u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03ba\u03b1\u03bd\u03b4\u03ac\u03bb\u03b7 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7\u03c2), \u03b5\u03af\u03c4\u03b5 \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03c3\u03bc\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae FOXO4 (\u03bf\u03c0\u03cc\u03c4\u03b5 \u03b7 \u03b5\u03ba\u03c4\u03cc\u03c0\u03b9\u03c3\u03b7 FOXO4-DRI \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03c4\u03af\u03c0\u03bf\u03c4\u03b1 \u03bd\u03b1 \u03b5\u03ba\u03c4\u03bf\u03c0\u03af\u03c3\u03b5\u03b9), \u03b5\u03af\u03c4\u03b5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b4\u03cd\u03bf \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03b5 \u03c0\u03bf\u03bb\u03cd \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1. \u03a4\u03bf FOXO4-DRI \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c0\u03b9\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc \u03b3\u03b9\u03b1 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03b5 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03bc\u03b5 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1.<\/li>\n<li><strong>\u0391\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c3\u03b5 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ac\u03c3\u03b5\u03c2 D-\u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03c9\u03bd<\/strong> \u2014 \u039f \u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03b1\u03bc\u03bc\u03ad\u03bd\u03bf\u03c2 \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03cc\u03c2 D-\u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03c9\u03bd \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03cd\u03b5\u03b9 \u03c4\u03bf \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03b1\u03c0\u03cc \u03c0\u03c1\u03c9\u03c4\u03b5\u03bf\u03bb\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03b9\u03ba\u03bf\u03b4\u03cc\u03bc\u03b7\u03c3\u03b7, \u03b5\u03c0\u03b9\u03bc\u03b7\u03ba\u03cd\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf\u03bd \u03c7\u03c1\u03cc\u03bd\u03bf \u03b7\u03bc\u03b9\u03b6\u03c9\u03ae\u03c2 in-vivo \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c0\u03c1\u03c9\u03c4\u03cc\u03ba\u03bf\u03bb\u03bb\u03b1 \u03b4\u03cc\u03c3\u03b7\u03c2 \u03b5\u03bd\u03b4\u03bf\u03c0\u03b5\u03c1\u03b9\u03c4\u03bf\u03bd\u03b1\u03ca\u03ba\u03ac \/ \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2.<\/li>\n<\/ul>\n<h2>\u0395\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ad\u03c2 \u0394\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7\u03c2 \u0388\u03c1\u03b5\u03c5\u03bd\u03b1\u03c2<\/h2>\n<ul>\n<li><strong>\u03a3\u03b7\u03bd\u03bf\u03bb\u03c5\u03c4\u03b9\u03ba\u03ae \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u2014 \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03cc \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1 \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03bf\u03c5<\/strong> \u2014 \u03c4\u03bf \u03c0\u03b9\u03bf \u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03cc\u03bc\u03b5\u03bd\u03bf \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03b9\u03ba\u03cc \u03c3\u03b7\u03bd\u03bf\u03bb\u03c5\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03b7 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b2\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/li>\n<li><strong>\u0388\u03c1\u03b5\u03c5\u03bd\u03b1 \u03c3\u03c4\u03b7 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7\u03c2<\/strong> \u2014 \u03b5\u03c0\u03b9\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03bc\u03ac\u03ba\u03c1\u03c5\u03bd\u03c3\u03b7 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b1\u03c0\u03cc \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03c0\u03bf\u03bd\u03c4\u03b9\u03ba\u03b9\u03ce\u03bd<\/li>\n<li><strong>\u03a6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2-\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 p53-FOXO4<\/strong> \u2014 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03bf \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03b9\u03ba\u03cc \u03bc\u03cc\u03c1\u03b9\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c5\u03c1\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03b4\u03b5\u03c3\u03bc\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 p53<\/li>\n<li><strong>\u0388\u03c1\u03b5\u03c5\u03bd\u03b1 \u03c3\u03b5 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 (TIS)<\/strong> \u2014 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc DOX, \u03b1\u03c0\u03bf\u03bc\u03ac\u03ba\u03c1\u03c5\u03bd\u03c3\u03b7 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1<\/li>\n<li><strong>\u0388\u03c1\u03b5\u03c5\u03bd\u03b1 \u03b1\u03bd\u03b1\u03b6\u03c9\u03bf\u03b3\u03cc\u03bd\u03b7\u03c3\u03b7\u03c2 \u03b9\u03c3\u03c4\u03ce\u03bd<\/strong> \u2014 \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03c5\u03ba\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03c1\u03b9\u03c7\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2, \u03b1\u03bd\u03c4\u03bf\u03c7\u03ae\u03c2 \u03c3\u03c4\u03b7\u03bd \u03ba\u03bf\u03cd\u03c1\u03b1\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c3\u03b5 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 (\u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 Baar 2017)<\/li>\n<li><strong>\u03a3\u03c5\u03b3\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03c3\u03b5\u03bd\u03bf\u03bb\u03c5\u03c4\u03b9\u03ba\u03ce\u03bd<\/strong> \u2014 \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03bc\u03b9\u03ba\u03c1\u03bf\u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ac \u03c3\u03b5\u03bd\u03bf\u03bb\u03c5\u03c4\u03b9\u03ba\u03ac (dasatinib + quercetin, fisetin, navitoclax, ABT-263)<\/li>\n<li><strong>\u03a3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03cc\u03c2 D-\u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03bf\u03c2 retro-inverso \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03c9\u03bd<\/strong> \u2014 \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1 \u03c4\u03b7\u03c2 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae\u03c2 \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03bf\u03cd \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ac\u03c3\u03b5\u03c2<\/li>\n<\/ul>\n<p>\u0393\u03b9\u03b1 \u03b5\u03c5\u03c1\u03cd\u03c4\u03b5\u03c1\u03bf \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03b4\u03b5\u03af\u03c4\u03b5 <a href=\"https:\/\/medsbase.com\/el\/epitalon\/\">\u0395\u03c0\u03b9\u03c4\u03b1\u03bb\u03cc\u03bd<\/a> (\u03c4\u03b5\u03c4\u03c1\u03b1\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf Khavinson \u03c0\u03b9\u03bd\u03b5\u03b1\u03bb\u03b9\u03ba\u03bf\u03cd \u03ac\u03be\u03bf\u03bd\u03b1 \u2014 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03bc\u03b1\u03ba\u03c1\u03bf\u03b6\u03c9\u03af\u03b1\u03c2), <a href=\"https:\/\/medsbase.com\/el\/ss-31-elamipretide\/\">SS-31 (Elamipretide)<\/a> (\u03bc\u03b9\u03c4\u03bf\u03c7\u03bf\u03bd\u03b4\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf\u03c2 \u03b1\u03bd\u03c4\u03b9\u03bf\u03be\u03b5\u03b9\u03b4\u03c9\u03c4\u03b9\u03ba\u03cc\u03c2), <a href=\"https:\/\/medsbase.com\/el\/mots-c\/\">MOTS-c<\/a> (\u03bc\u03b9\u03c4\u03bf\u03c7\u03bf\u03bd\u03b4\u03c1\u03b9\u03b1\u03ba\u03cc \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf), <a href=\"https:\/\/medsbase.com\/el\/5-amino-1mq\/\">5-Amino-1MQ<\/a> (\u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1\u03c2 NNMT \u03ac\u03be\u03bf\u03bd\u03b1 NAD). \u03a0\u03b5\u03c1\u03b9\u03b7\u03b3\u03b7\u03b8\u03b5\u03af\u03c4\u03b5 \u03c3\u03c4\u03b7\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 <a href=\"https:\/\/medsbase.com\/el\/peptides\/\">\u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1\u03c2 \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03c9\u03bd<\/a>, \u03ae \u03b4\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03bf <a href=\"https:\/\/medsbase.com\/el\/best-longevity-peptides\/\">\u03b5\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1\u03c2 \u03bc\u03b1\u03ba\u03c1\u03bf\u03b6\u03c9\u03af\u03b1\u03c2<\/a> .<\/p>\n<h2>\u0394\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b5\u03c2 \u03b4\u03c5\u03bd\u03ac\u03bc\u03b5\u03b9\u03c2<\/h2>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px;\">\u0394\u03cd\u03bd\u03b1\u03bc\u03b7 \u03a6\u03b9\u03b1\u03bb\u03b9\u03b4\u03af\u03bf\u03c5<\/th>\n<th style=\"padding: 10px;\">\u039c\u03b5\u03b3\u03ad\u03b8\u03b7 \u03a3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1\u03c2<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>10 mg<\/strong> \u2014 \u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03b9\u03c3\u03c7\u03cd\u03c2 \u03b3\u03b9\u03b1 \u03c0\u03c1\u03c9\u03c4\u03cc\u03ba\u03bf\u03bb\u03bb\u03b1 senolytic in-vivo \u03ba\u03b1\u03b9 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03cc\u03b3\u03ba\u03bf (TIS)\u00b7 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03ba\u03cc\u03c3\u03c4\u03bf\u03c2 \u03b1\u03bd\u03ac mg \u03c3\u03b5 \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 20 \u03c6\u03b9\u03b1\u03bb\u03ce\u03bd<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10 \u03ae 20 \u03c6\u03b9\u03b1\u03bb\u03af\u03b4\u03b9\u03b1<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div style=\"background: #f4f8fb; border-left: 4px solid #2c7cb0; padding: 14px 18px; margin: 18px 0;\"><strong class=\"mb-bac-water-callout\">\ud83d\udca7 \u03a7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c3\u03c4\u03b5 BAC \u03bd\u03b5\u03c1\u03cc;<\/strong> \u0397 \u03b1\u03bd\u03b1\u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03bf\u03c0\u03bf\u03b9\u03b1\u03c3\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03bb\u03c5\u03bf\u03c6\u03b9\u03bb\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c6\u03b9\u03ac\u03bb\u03b7\u03c2 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03c3\u03c4\u03b5\u03b9\u03c1\u03cc \u03b2\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03bf\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03bd\u03b5\u03c1\u03cc. \u03a3\u03c5\u03b6\u03b5\u03cd\u03be\u03c4\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd \u03bc\u03b5 \u03c4\u03bf <a href=\"\/el\/bac-water\/\"><strong>\u039d\u03b5\u03c1\u03cc BAC (\u0392\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03bf\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u039d\u03b5\u03c1\u03cc)<\/strong><\/a> \u2014 \u03c6\u03b9\u03ac\u03bb\u03b7 30 mL \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ce\u03bd \u03b4\u03cc\u03c3\u03b5\u03c9\u03bd, \u03bc\u03b5 0,9% \u03c3\u03c5\u03bd\u03c4\u03b7\u03c1\u03b7\u03c4\u03b9\u03ba\u03cc \u03b2\u03b5\u03bd\u03b6\u03c5\u03bb-\u03b1\u03bb\u03ba\u03bf\u03cc\u03bb, \u03b2\u03b1\u03b8\u03bc\u03bf\u03cd USP.<\/div>\n<h2>\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7<\/h2>\n<p>\u039b\u03c5\u03bf\u03c6\u03b9\u03bb\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf 2\u20138 \u00b0C \u03b2\u03c1\u03b1\u03c7\u03c5\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b1, \u221220 \u00b0C \u03bc\u03b1\u03ba\u03c1\u03bf\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b1. \u0391\u03bd\u03b1\u03c3\u03c5\u03b3\u03ba\u03c1\u03cc\u03c4\u03b7\u03c3\u03b7 \u03bc\u03b5 \u03b2\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03bf\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03bd\u03b5\u03c1\u03cc (1,0 mL \u03b1\u03bd\u03ac \u03c6\u03b9\u03b1\u03bb\u03af\u03b4\u03b9\u03bf 10 mg \u2192 10 mg\/mL). \u0391\u03c0\u03bf\u03c6\u03cd\u03b3\u03b5\u03c4\u03b5 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03ac\u03c8\u03c5\u03be\u03b7-\u03b1\u03c0\u03cc\u03c8\u03c5\u03be\u03b7.<\/p>\n<h2>\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3>\u0395\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf FOXO4-DRI \u03c4\u03bf \u03af\u03b4\u03b9\u03bf \u03bc\u03b5 \u03c4\u03bf FOX04-DRI;<\/h3>\n<p>\u039d\u03b1\u03b9 \u2014 \u03c4\u03bf \u201cFOX04-DRI\u201d \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03ba\u03bf\u03b9\u03bd\u03ae \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03bf\u03c1\u03b8\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1 \u03cc\u03c0\u03bf\u03c5 \u03c4\u03bf \u03b3\u03c1\u03ac\u03bc\u03bc\u03b1 \u201cO\u201d \u03b3\u03c1\u03ac\u03c6\u03b5\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03c8\u03b7\u03c6\u03af\u03bf \u201c0\u201d. \u03a4\u03bf \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03bf\u03bd\u03bf\u03bc\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c9\u03c3\u03c4\u03ac \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03cc \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 FOXO4 (Forkhead box O4). \u039a\u03b1\u03b9 \u03bf\u03b9 \u03b4\u03cd\u03bf \u03bf\u03c1\u03b8\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b5\u03c2 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03af\u03b4\u03b9\u03bf senolytic \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 Baar\/de Keizer\/Demaria 2017 Cell.<\/p>\n<h3>\u03a0\u03bf\u03b9\u03b5\u03c2 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ad\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03c3\u03b5 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b5\u03c2;<\/h3>\n<p>\u0397 \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 Baar 2017 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b5 1\u20135 mg\/kg \u03b5\u03bd\u03b4\u03bf\u03c0\u03b5\u03c1\u03b9\u03c4\u03bf\u03bd\u03b1\u03ca\u03ba\u03ac \u03c4\u03c1\u03b5\u03b9\u03c2 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03c4\u03b7\u03bd \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1 \u03b3\u03b9\u03b1 \u03ba\u03cd\u03ba\u03bb\u03bf\u03c5\u03c2 4 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03c9\u03bd \u03c3\u03b5 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1. \u0386\u03bb\u03bb\u03b1 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 \u03c0\u03c1\u03c9\u03c4\u03cc\u03ba\u03bf\u03bb\u03bb\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 1\u201310 mg\/kg \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03bf \u03ba\u03b1\u03b9 \u03c4\u03bf \u03c4\u03b5\u03bb\u03b9\u03ba\u03cc \u03c3\u03b7\u03bc\u03b5\u03af\u03bf. \u0397 in-vitro \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03bf\u03c5 \u03c3\u03b5 \u03bc\u03b9\u03ba\u03c1\u03bf\u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ad\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2.<\/p>\n<h3>\u0393\u03b9\u03b1\u03c4\u03af D-\u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03b1 retro-inverso;<\/h3>\n<p>\u03a4\u03bf \u03c3\u03c7\u03ad\u03b4\u03b9\u03bf retro-inverse \u03bc\u03b5 \u03cc\u03bb\u03b1 D-\u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03b1 \u03c0\u03b1\u03c1\u03ad\u03c7\u03b5\u03b9 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c0\u03bb\u03ae\u03c1\u03b7 \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03c4\u03b9\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ac\u03c3\u03b5\u03c2 \u2014 \u03bf\u03b9 \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03ac\u03c3\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03be\u03b5\u03bd\u03b9\u03c3\u03c4\u03ae \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03bc\u03cc\u03bd\u03bf L-\u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03b1. \u0391\u03c5\u03c4\u03cc \u03b5\u03c0\u03b5\u03ba\u03c4\u03b5\u03af\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03c7\u03c1\u03cc\u03bd\u03bf \u03b7\u03bc\u03b9\u03b6\u03c9\u03ae\u03c2 \u03c3\u03c4\u03bf \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1 \u03c3\u03b5 \u03ce\u03c1\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac \u03c0\u03c1\u03c9\u03c4\u03cc\u03ba\u03bf\u03bb\u03bb\u03b1 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 in-vivo \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03b8\u03b1 \u03ae\u03c4\u03b1\u03bd \u03b5\u03c6\u03b9\u03ba\u03c4\u03ac \u03bc\u03b5 \u03c4\u03b7 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ae \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03af\u03b1 L-\u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03c9\u03bd \u03c4\u03bf\u03c5 FOXO4 (\u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b8\u03b1 \u03b1\u03c0\u03bf\u03b4\u03bf\u03bc\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b5 \u03bb\u03af\u03b3\u03b1 \u03bb\u03b5\u03c0\u03c4\u03ac).<\/p>\n<h3>\u0388\u03c7\u03b5\u03b9 \u03c4\u03bf FOXO4-DRI \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ac\u03c3\u03c7\u03b5\u03b9 \u03c3\u03b5 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2;<\/h3>\n<p>\u0394\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03bf\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03c9\u03b8\u03b5\u03af \u03c4\u03c5\u03c0\u03b9\u03ba\u03ad\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03a6\u03ac\u03c3\u03b7\u03c2 I\/II \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf FOXO4-DRI \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1. \u0397 \u03ad\u03bd\u03c9\u03c3\u03b7 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03ad\u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03b5\u03c1\u03b3\u03b1\u03bb\u03b5\u03af\u03bf. \u0386\u03bb\u03bb\u03b1 senolytics (dasatinib + quercetin, fisetin) \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae-\u03bc\u03b5\u03c4\u03b1\u03c6\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03c7\u03c9\u03c1\u03b9\u03c3\u03c4\u03ac.<\/p>\n<h3>\u03a0\u03bf\u03b9\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03bf\u03c5 FOXO4-DRI \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03c9\u03bd senolytics;<\/h3>\n<p>\u03a4\u03bf FOXO4-DRI \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03cc \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03b9\u03ba\u03cc senolytic. \u0386\u03bb\u03bb\u03b5\u03c2 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b5\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 senolytics \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd: (\u03b1) \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03cd\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 \/ \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2 BCL-2 (dasatinib + quercetin)\u00b7 (\u03b2) \u03c6\u03bb\u03b1\u03b2\u03bf\u03bd\u03bf\u03b5\u03b9\u03b4\u03ae (fisetin)\u00b7 (\u03b3) BH3 \u03bc\u03b9\u03bc\u03b7\u03c4\u03b9\u03ba\u03ac (navitoclax \/ ABT-263)\u00b7 (\u03b4) \u03ac\u03bb\u03bb\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bc\u03b2\u03ac\u03c3\u03b5\u03b9\u03c2 \u03bf\u03b4\u03bf\u03cd p53-FOXO4. \u039f\u03b9 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03b5\u03c0\u03b9\u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03bd \u03bc\u03ad\u03c1\u03b5\u03b9 \u03b1\u03bb\u03bb\u03ac \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03bf\u03c5\u03bd \u03c3\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c4\u03c5\u03c7\u03ad\u03c2 \u03c4\u03c9\u03bd \u03bc\u03bf\u03bd\u03bf\u03c0\u03b1\u03c4\u03b9\u03ce\u03bd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd.<\/p>\n<div class=\"medsbase-trust-strip\" style=\"background: #f4f8fb; border: 1px solid #d8e3eb; padding: 12px 16px; margin: 20px 0 8px; border-radius: 4px; font-size: 14px;\"><strong>\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03b1\u03b3\u03bf\u03c1\u03ac\u03c3\u03b5\u03c4\u03b5 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase:<\/strong> \u039b\u03c5\u03bf\u03c6\u03b9\u03bb\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1 &amp; \u03b5\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2 HPLC \u226599% \u00b7 \u03a0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7\u03c2 (COA) \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03bf \u03ba\u03b1\u03c4\u03cc\u03c0\u03b9\u03bd \u03b1\u03b9\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u00b7 \u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae \u03c3\u03b5 \u03b8\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03af\u03b1 \u00b7 \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u03bc\u03b5 courier \u00b7 <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance<\/a> \u03c3\u03b5 \u03ba\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u00b7 \u03c0\u03ac\u03bd\u03c9 \u03b1\u03c0\u03cc 1.400 \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 <a href=\"https:\/\/medsbase.com\/el\/reviews\/\">\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a><\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>\u0386\u03bb\u03bb\u03b1 \u03a0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1 \u0388\u03c1\u03b5\u03c5\u03bd\u03b1\u03c2 \u039c\u03b1\u03ba\u03c1\u03bf\u03b6\u03c9\u03af\u03b1\u03c2 \/ \u0393\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7\u03c2<\/h2>\n<ul>\n<li><a href=\"\/el\/epitalon\/\"><strong>\u0395\u03c0\u03b9\u03c4\u03b1\u03bb\u03cc\u03bd<\/strong><\/a> \u2014 \u03b2\u03b9\u03bf\u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c4\u03b5\u03c4\u03c1\u03b1\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03ac\u03be\u03bf\u03bd\u03b1 \u03c0\u03b5\u03c5\u03ba\u03b9\u03b1\u03bb\u03b9\u03ba\u03bf\u03cd Khavinson<\/li>\n<li><a href=\"\/el\/ss-31-elamipretide\/\"><strong>SS-31 (Elamipretide)<\/strong><\/a> \u2014 \u0391\u03bd\u03c4\u03b9\u03bf\u03be\u03b5\u03b9\u03b4\u03c9\u03c4\u03b9\u03ba\u03cc \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03bc\u03b5 \u03c3\u03c4\u03cc\u03c7\u03bf \u03c4\u03b1 \u03bc\u03b9\u03c4\u03bf\u03c7\u03cc\u03bd\u03b4\u03c1\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03bb\u03b9\u03c0\u03af\u03bd\u03b7<\/li>\n<li><a href=\"\/el\/mots-c\/\"><strong>MOTS-c<\/strong><\/a> \u2014 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03cc \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03bc\u03b9\u03c4\u03bf\u03c7\u03bf\u03bd\u03b4\u03c1\u03b9\u03b1\u03ba\u03ae\u03c2 \u03c0\u03c1\u03bf\u03ad\u03bb\u03b5\u03c5\u03c3\u03b7\u03c2<\/li>\n<li><a href=\"\/el\/5-amino-1mq\/\"><strong>5-Amino-1MQ<\/strong><\/a> \u2014 \u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1\u03c2 NNMT \u2014 \u03b5\u03be\u03bf\u03b9\u03ba\u03bf\u03bd\u03cc\u03bc\u03b7\u03c3\u03b7 \u03c0\u03c1\u03bf\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03ac\u03be\u03bf\u03bd\u03b1 NAD<\/li>\n<li><a href=\"\/el\/nad\/\"><strong>NAD\u207a<\/strong><\/a> \u2014 \u0386\u03bc\u03b5\u03c3\u03b7 \u03c3\u03c5\u03bc\u03c0\u03bb\u03ae\u03c1\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03b5\u03be\u03b1\u03bc\u03b5\u03bd\u03ae\u03c2 \u03b4\u03b9\u03c0\u03bb\u03ce\u03bd \u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03b9\u03b4\u03af\u03c9\u03bd<\/li>\n<li><a href=\"\/el\/bac-water\/\"><strong>\u039d\u03b5\u03c1\u03cc BAC (\u0392\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03bf\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u039d\u03b5\u03c1\u03cc)<\/strong><\/a> \u2014 \u0391\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03bf\u03c0\u03bf\u03b9\u03b1\u03c3\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03bb\u03c5\u03bf\u03c6\u03b9\u03bb\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c6\u03b9\u03ac\u03bb\u03b7\u03c2 \u2014 \u03b1\u03c0\u03bf\u03c3\u03c4\u03b5\u03b9\u03c1\u03c9\u03bc\u03ad\u03bd\u03bf, 0.9% \u03b4\u03b9\u03b1\u03bb\u03cd\u03c4\u03b7 \u03bc\u03b5 \u03c3\u03c5\u03bd\u03c4\u03b7\u03c1\u03b7\u03c4\u03b9\u03ba\u03cc \u03b2\u03b5\u03bd\u03b6\u03c5\u03bb\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bb\u03ba\u03bf\u03cc\u03bb\u03b7\u03c2<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 \u03a3\u03c5\u03bd\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc ~28-aa D-\u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03bf\u03c2 retro-inverso \u03c3\u03b5\u03bd\u03bf\u03bb\u03c5\u03c4\u03b9\u03ba\u03cc \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf<br \/>\n\u2705 \u0394\u03b9\u03b1\u03c4\u03b1\u03c1\u03ac\u03c3\u03c3\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 FOXO4-p53 \u2192 \u03c0\u03c5\u03c1\u03b7\u03bd\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03ac\u03b8\u03b5\u03c3\u03b7 p53 \u2192 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd<br \/>\n\u2705 \u03a3\u03c0\u03bf\u03c5\u03b4\u03b1\u03af\u03bf \u03ad\u03c1\u03b3\u03bf Baar\/de Keizer\/Demaria 2017 Cell-paper<br \/>\n\u2705 \u0395\u03c0\u03b9\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03c3\u03b5\u03bd\u03bf\u03bb\u03cd\u03c3\u03b7: \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03b5 \u03bc\u03b7 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1\u00b7 \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc \u03c3\u03b5 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ac\u03c3\u03b5\u03c2 \u03bb\u03cc\u03b3\u03c9 D-AA \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03bf\u03cd<br \/>\n\u2705 \u039c\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc \u03b2\u03ac\u03c1\u03bf\u03c2 ~3.000 Da\u00b7 \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03cc \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03b5\u03c1\u03b3\u03b1\u03bb\u03b5\u03af\u03bf \u03c3\u03b5\u03bd\u03bf\u03bb\u03c5\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03c9\u03bd<\/p>\n<p><strong>FOXO4-DRI<\/strong> (\u03b5\u03c0\u03af\u03c3\u03b7\u03c2 FOX04-DRI) \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 \u03c3\u03c5\u03bd\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc retro-inverso \u03c3\u03b5\u03bd\u03bf\u03bb\u03c5\u03c4\u03b9\u03ba\u03cc \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf.<\/p>","protected":false},"featured_media":71534,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[5426],"product_tag":[6569,6568,6565,6564,6567,6494,6570,6566],"class_list":{"0":"post-71515","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptides","7":"product_tag-anti-ageing-research","8":"product_tag-d-retro-inverso-peptide","9":"product_tag-fox04-dri","10":"product_tag-foxo4-dri","11":"product_tag-p53-foxo4-inhibitor","12":"product_tag-research-peptide","13":"product_tag-senescent-cell-clearance","14":"product_tag-senolytic-peptide","16":"first","17":"instock","18":"shipping-taxable","19":"purchasable","20":"product-type-variable","21":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/71515","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=71515"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/71534"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=71515"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=71515"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=71515"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=71515"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}