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Glycomet-GP<\/strong> is a fixed-dose combination tablet containing Glimepiride<\/a> (1 mg or 2 mg)<\/strong> and metformin (500 mg)<\/strong> for the treatment of type 2 diabetes<\/strong>. It combines two complementary mechanisms in a single tablet: metformin reduces the liver’s glucose output and improves insulin sensitivity, while glimepiride stimulates the pancreas to release more insulin. Usual dose is one tablet twice daily with breakfast and dinner. Typical HbA1c reduction: 1.5–2.0 percentage points<\/strong>. Main side effects: GI upset from metformin (first 1–2 weeks) and hypoglycaemia from the sulfonylurea. Glimepiride is a third-generation sulfonylurea with lower hypoglycaemia risk than glibenclamide. Avoid in severe renal impairment (eGFR < 30), decompensated heart failure, acute illness with dehydration, and sulfa allergy.<\/p>\n<\/div>\n \ud83d\udce6 Every order is covered by our Reshipment Assurance Policy<\/strong><\/a> \u2014 if your parcel does not arrive within 20 business days, we reship it.<\/p>\n Our generic medications are sourced from WHO-GMP certified manufacturers and shipped worldwide in discreet, plain packaging \u2014 no medication name on the parcel exterior. Card payments are routed through a regulated processor (statement descriptors include a regulated card-payment processor \u2014 never “MedsBase” or any medication name). Crypto and SEPA bank transfer are also accepted. Every order is backed by our Reshipment Assurance Policy.<\/p>\n Glycomet-GP is a fixed-dose combination (FDC)<\/strong> oral antidiabetic medicine containing two active ingredients: Glimepiride (1 mg or 2 mg)<\/strong> and metformin hydrochloride (500 mg)<\/strong>, manufactured by USV Pharma. Available in packs of 30, 60, 90 or 180 tablets.<\/p>\n Combination tablets simplify the regimen (one tablet instead of two), improve adherence, and are typically less expensive than the two components bought separately. Glycomet-GP is usually prescribed when metformin monotherapy is not achieving HbA1c targets.<\/p>\n The two components attack hyperglycaemia from different angles — this is why combination therapy is more effective than up-titrating either drug alone:<\/p>\n Together, the two mechanisms produce an HbA1c fall of 1.5–2.0 percentage points<\/strong>, substantially more than metformin monotherapy.<\/p>\n Starting dose:<\/strong> One tablet of Glycomet-GP with the main meal (breakfast). If glycaemia is not controlled after 2–4 weeks, increase to one tablet twice daily — with breakfast and dinner.<\/p>\n From the metformin component (usually in the first 1–2 weeks):<\/strong><\/p>\n From the sulfonylurea component:<\/strong><\/p>\n Uncommon but serious:<\/strong><\/p>\n Raise hypoglycaemia risk:<\/strong> insulin, other antidiabetics, alcohol (especially binge), trimethoprim\/sulfamethoxazole, fluconazole, clarithromycin, ACE inhibitors, high-dose salicylates, non-selective beta-blockers (which also mask hypo symptoms), MAOIs.<\/p>\n Raise lactic acidosis risk (metformin):<\/strong> IV iodinated contrast, carbonic anhydrase inhibitors (acetazolamide, topiramate), cationic drugs (cimetidine, dolutegravir, ranolazine).<\/p>\n Reduce glucose-lowering effect:<\/strong> corticosteroids, thiazide diuretics, thyroid hormones, phenytoin, rifampicin, atypical antipsychotics, oral contraceptives.<\/p>\n Store Glycomet-GP below 25°C in a dry place, in the original blister pack. Keep out of reach of children.<\/p>\n Clinically, yes — the fixed-dose combination delivers the same active ingredients at the same doses as the two tablets taken together. The advantage is fewer pills, better adherence, and typically lower cost. The trade-off is less dose flexibility: if either component needs changing, the FDC has to be swapped for the separate tablets.<\/p>\n When metformin monotherapy at maximum tolerated dose is no longer controlling HbA1c. Most guidelines (ADA, EASD, NICE) recommend adding a second agent when HbA1c is > 7.5% on metformin alone. A sulfonylurea is a widely used second-line option because it is inexpensive and effective, although DPP-4 inhibitors and SGLT-2 inhibitors are now preferred in people with cardiovascular or renal comorbidities.<\/p>\n Yes — because it contains a sulfonylurea. Skipping meals, unusual exercise, alcohol, and certain drug interactions raise the risk. Always take Glycomet-GP with food and carry fast-acting carbohydrate. Severe or prolonged hypoglycaemia needs medical review.<\/p>\n Modest weight gain (1–3 kg) is common because of the sulfonylurea component. Metformin is weight-neutral or slightly weight-reducing, so the FDC usually causes less gain than sulfonylurea monotherapy.<\/p>\n Moderate alcohol with food is generally safe. Avoid binge drinking and alcohol on an empty stomach — both raise hypoglycaemia risk (from the sulfonylurea) and lactic acidosis risk (from metformin).<\/p>\n Yes, particularly in the first 2–4 weeks, after dose changes, or during illness. HbA1c should be checked every 3–6 months.<\/p>\n You can order Glycomet-GP (500\/1 mg or 500\/2 mg) from MedsBase in packs of 30, 60, 90 or 180 tablets. We ship worldwide, with discreet packaging and genuine WHO-GMP certified manufacturer stock.<\/p>\n Many patients reach Glycomet-GP only after starting on metformin monotherapy; if you’re newly diagnosed or want both first-line and step-up therapy bundled, our Diabetes Starter Pack (Glycomet SR 1000 mg + Glycomet-GP)<\/a> ships the ADA\/EASD-aligned starter regimen in one parcel.<\/p>\n <\/p>\n Other products in Chronic Conditions<\/strong> that customers also view:<\/p>\n Glycomet-GP contains Metformin and Glimepiride<\/span><\/p>\n","protected":false},"featured_media":50638,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3230,3231],"product_tag":[3251,3254,3255],"class_list":{"0":"post-50637","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-diabetes","9":"product_cat-diabetes-medication","10":"product_tag-glimepiride","11":"product_tag-glycomet-gp","12":"product_tag-metformin","14":"first","15":"instock","16":"shipping-taxable","17":"purchasable","18":"product-type-variable","19":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product\/50637","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/comments?post=50637"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/media\/50638"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/media?parent=50637"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product_brand?post=50637"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product_cat?post=50637"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product_tag?post=50637"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Why order from MedsBase<\/h3>\n
What Is Glycomet-GP?<\/h2>\n
How Does Glycomet-GP Work?<\/h2>\n
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Dosage and Administration<\/h2>\n
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Side Effects<\/h2>\n
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Drug Interactions<\/h2>\n
Who Should Not Take Glycomet-GP?<\/h2>\n
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Storage<\/h2>\n
Frequently Asked Questions<\/h2>\n
Is Glycomet-GP the same as taking metformin and glimepiride separately?<\/h3>\n
When is Glycomet-GP usually added to a diabetes regimen?<\/h3>\n
Can Glycomet-GP cause low blood sugar (hypoglycaemia)?<\/h3>\n
Will Glycomet-GP cause weight gain?<\/h3>\n
Can I drink alcohol while taking Glycomet-GP?<\/h3>\n
Do I still need to check my blood sugar?<\/h3>\n
Where can I buy Glycomet-GP online?<\/h3>\n
Related Diabetes Medications<\/h2>\n
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Related Alternatives<\/h3>\n
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\u2705 Dual-action diabetes management
\n\u2705 Controls blood sugar levels
\n\u2705 Supports insulin sensitivity
\n\u2705 Minimizes diabetes-related complications<\/h5>\n