{"id":52350,"date":"2023-09-20T09:32:18","date_gmt":"2023-09-20T09:32:18","guid":{"rendered":"https:\/\/medsname.com\/azee\/"},"modified":"2026-04-30T10:18:14","modified_gmt":"2026-04-30T10:18:14","slug":"azee","status":"publish","type":"product","link":"https:\/\/medsbase.com\/azee\/","title":{"rendered":"Azee"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div class=\"medsbase-tldr-answer\" style=\"background:#fffbe6;border-left:4px solid #f5a623;padding:14px 18px;margin:14px 0 22px;border-radius:6px;font-size:15px;line-height:1.55;\">\n<h3 style=\"margin:0 0 6px;font-size:17px;color:#8a6d3b;\">\u26a1 Quick Answer \u2014 What is Azee?<\/h3>\n<p style=\"margin:0;\">Azee is an <strong>azithromycin tablet (250 mg \/ 500 mg, Cipla)<\/strong> \u2014 the most-used macrolide globally. Standard adult regimen is 500 mg once daily for 3 days for sinusitis or chest infection, or 1 g single dose for chlamydia. Long intracellular half-life allows short courses with continued antibacterial effect for 7 days.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f6f7fb;border:1px solid #e3e5ee;border-radius:8px;padding:14px 18px;margin:18px 0;font-size:14px;line-height:1.55;\"><strong style=\"color:#1f3661;\">Why order from MedsBase?<\/strong> Sourced from a WHO-GMP certified manufacturer \u00b7 Discreet packaging \u00b7 Worldwide Shipping \u00b7 <a href=\"\/reviews\/\" rel=\"noopener\">1,400+ verified customer reviews<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Every order is covered by our <a href=\"https:\/\/medsbase.com\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 if your parcel does not arrive within 20 business days, we reship it.<\/p>\n<h3>Why order from MedsBase<\/h3>\n<p>Our generic medications are sourced from WHO-GMP certified manufacturers and shipped worldwide in discreet, plain packaging \u2014 no medication name on the parcel exterior. Card payments are routed through a regulated processor (statement descriptors include a regulated card-payment processor \u2014 never &ldquo;MedsBase&rdquo; or any medication name). Crypto and SEPA bank transfer are also accepted. Every order is backed by our Reshipment Assurance Policy.<\/p>\n<h2 id=\"mechanism\">How Azee works<\/h2>\n<p>Azee contains <strong>Azithromycin<\/strong>, a macrolide antibiotic that binds the 50S bacterial ribosomal subunit and blocks peptide-chain elongation, arresting bacterial protein synthesis. Macrolides are bacteriostatic at standard doses but bactericidal at higher concentrations against susceptible organisms. Spectrum includes Streptococcus species (including some penicillin-resistant pneumococci), Mycoplasma pneumoniae, Chlamydia trachomatis and pneumoniae, Legionella, Bordetella, and Helicobacter pylori. Activity against staphylococci is unreliable due to widespread macrolide resistance, and most Enterobacteriaceae are intrinsically resistant.<\/p>\n<p>Azithromycin is the most commonly used macrolide because of its extended half-life (~68 hours intracellularly), simple dosing schedules, and lower CYP3A4 inhibition compared with erythromycin or clarithromycin.<\/p>\n<h2 id=\"indications\">Indications &amp; dosing<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:14px;\">\n<caption style=\"text-align:left;font-weight:bold;margin-bottom:6px;\">Adult dosing<\/caption>\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;border:1px solid #ddd;text-align:left;\">Indication<\/th>\n<th style=\"padding:8px;border:1px solid #ddd;text-align:left;\">Dose<\/th>\n<th style=\"padding:8px;border:1px solid #ddd;text-align:left;\">Duration<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Acute bacterial sinusitis \/ mild CAP<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">500 mg day 1, then 250 mg daily \u2014 total 5 days<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">5 days<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Acute bacterial sinusitis (alternative regimen)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">500 mg once daily<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">3 days<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Streptococcal pharyngitis (penicillin-allergic)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">500 mg day 1, then 250 mg daily<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">5 days<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Uncomplicated chlamydial urethritis \/ cervicitis<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">1 g single dose<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Single dose<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Uncomplicated gonorrhoea (in combination with ceftriaxone)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">1 g single dose<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Single dose<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Mycoplasma genitalium (extended regimen)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">500 mg day 1, then 250 mg daily<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">5 days<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Travellers&#8217; diarrhoea (developing-world)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">500 mg\u20131 g daily<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">3 days<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Pertussis (whooping cough)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">500 mg day 1, then 250 mg daily<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">5 days<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">MAC prophylaxis in HIV (CD4 &lt; 50)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">1.2 g once weekly<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Until CD4 &gt; 100 sustained<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:6px;\"><strong style=\"color:#a94442;\">\u26a0 QT prolongation \u2014 class warning<\/strong><\/p>\n<div style=\"margin-top:6px;font-size:14px;line-height:1.55;\">\n<p style=\"margin:0;\">All macrolides can prolong the QT interval and trigger torsades de pointes \u2014 particularly in patients with congenital long QT, electrolyte disturbance (low K+ \/ Mg2+), bradycardia, concurrent QT-prolonging medications (azoles, fluoroquinolones, citalopram, ondansetron, certain antipsychotics, some antiarrhythmics) or significant cardiac disease. Azithromycin received an FDA black-box update in 2013 after observational data linked it to a small absolute increase in cardiovascular death in patients with elevated baseline cardiac risk. Patients with stable cardiovascular disease can usually receive a macrolide safely; high-risk patients \u2014 known long-QT, recent MI, advanced heart failure \u2014 may need an alternative class.<\/p>\n<\/div>\n<\/div>\n<h2 id=\"side-effects\">Side effects<\/h2>\n<ul>\n<li><strong>GI:<\/strong> nausea, abdominal cramps, diarrhoea (worst with erythromycin \u2014 affects up to 30% of patients due to motilin agonism). Azithromycin \/ clarithromycin \/ roxithromycin are better tolerated.<\/li>\n<li><strong>Taste disturbance \/ metallic taste:<\/strong> common with clarithromycin; bothersome but reversible.<\/li>\n<li><strong>Hepatotoxicity:<\/strong> cholestatic hepatitis (rare with azithromycin; more common with erythromycin estolate). Watch for jaundice, RUQ pain.<\/li>\n<li><strong>QT prolongation \/ torsades:<\/strong> rare absolute risk but real (see warning above).<\/li>\n<li><strong>Hearing impairment:<\/strong> reversible ototoxicity reported with high-dose macrolides, especially in renal impairment.<\/li>\n<li><strong>Allergic reactions:<\/strong> rash, urticaria, very rarely Stevens-Johnson \/ TEN.<\/li>\n<\/ul>\n<h2 id=\"contraindications\">Contraindications<\/h2>\n<ul>\n<li>Known macrolide hypersensitivity.<\/li>\n<li>Concurrent use with strong QT-prolonging drugs (especially Class IA \/ III antiarrhythmics).<\/li>\n<li>Severe hepatic impairment (especially erythromycin estolate).<\/li>\n<li>Concurrent ergot alkaloids (vasospasm risk with strong CYP3A4 inhibitors \u2014 clarithromycin\/erythromycin).<\/li>\n<li>Concurrent terfenadine \/ astemizole \/ cisapride \/ pimozide \/ lovastatin \/ simvastatin (with strong CYP3A4 inhibitors only).<\/li>\n<\/ul>\n<h2 id=\"interactions\">Drug interactions<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:14px;\">\n<caption style=\"text-align:left;font-weight:bold;margin-bottom:6px;\">Selected major interactions<\/caption>\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;border:1px solid #ddd;text-align:left;\">Drug<\/th>\n<th style=\"padding:8px;border:1px solid #ddd;text-align:left;\">Effect<\/th>\n<th style=\"padding:8px;border:1px solid #ddd;text-align:left;\">Action<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Warfarin<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">INR rise \u2014 multiple mechanisms<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Check INR 3\u20135 days in; counsel<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Statins (simvastatin \/ lovastatin)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Severe rhabdomyolysis risk with clarithromycin \/ erythromycin<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Hold statin during course (atorvastatin \/ rosuvastatin \/ pravastatin \/ fluvastatin are safer)<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Calcium-channel blockers (verapamil \/ diltiazem \/ amlodipine)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Hypotension \/ shock with clarithromycin<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Avoid combination in elderly<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Colchicine<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Severe colchicine toxicity (especially in renal impairment)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Hold colchicine or use alternative antibiotic<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Carbamazepine \/ phenytoin<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Increased levels via CYP3A4 inhibition (clari\/eryth)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Monitor levels<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Ergot alkaloids<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Severe peripheral vasospasm (clari\/eryth)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Absolute contraindication<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Digoxin<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Raises digoxin levels via gut-flora effect<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Monitor digoxin level<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Quetiapine \/ pimozide<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">QT prolongation<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Avoid combination<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3 id=\"pregnancy\">Pregnancy &amp; Breastfeeding<\/h3>\n<p>Macrolides are <strong>FDA category B<\/strong>. Erythromycin and azithromycin are widely used in pregnancy. <em>Clarithromycin is category C<\/em> \u2014 reserve for situations where benefit outweighs risk; alternatives (azithromycin, amoxicillin) are preferred. For chlamydia in pregnancy, azithromycin 1 g single dose is first-line. All macrolides cross into breast milk in small amounts; compatible with breastfeeding.<\/p>\n<h3 id=\"storage\">Storage<\/h3>\n<p>Store below 25 \u00b0C, away from direct sunlight and moisture. Keep in original packaging. Keep out of reach of children. Discard any unused tablets after the printed expiry date \u2014 degraded antibiotics can lose potency or release breakdown products.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:6px;\"><strong style=\"color:#a94442;\">\u26a0 Antibiotic resistance \u2014 please use responsibly<\/strong><\/p>\n<div style=\"margin-top:6px;font-size:14px;line-height:1.55;\">\n<p style=\"margin:0;\">This medicine is only effective against bacterial infections. Do not use it for viral illnesses (common cold, most sore throats, flu, COVID-19), do not stop early when you feel better, and do not save leftovers for future infections. Misuse drives drug-resistant bacteria like MRSA, ESBL, and CRE \u2014 the WHO ranks antimicrobial resistance among the top 10 global public-health threats.<\/p>\n<\/div>\n<\/div>\n<h2 id=\"faqs\">Frequently Asked Questions<\/h2>\n<h3>How fast does Azee work?<\/h3>\n<p>Most patients begin to feel better within 48\u201372 hours. Azithromycin&#8217;s long intracellular half-life means treatment continues for ~7 days even after a 5-day course ends \u2014 do not assume the course is too short.<\/p>\n<h3>Should I take it with food?<\/h3>\n<p>Azithromycin tablets\/suspensions can be taken with or without food. Take on an empty stomach if you suspect tetracycline-style chelation with calcium \/ iron \u2014 this is not a major concern with azithromycin.<\/p>\n<h3>Can I take it if I have heart disease?<\/h3>\n<p>Stable cardiovascular disease is not an absolute contraindication. Patients with congenital long-QT, recent acute coronary events, advanced heart failure, or concurrent QT-prolonging medications should discuss alternatives with their prescriber.<\/p>\n<h3>Why does my doctor avoid clarithromycin with my statin?<\/h3>\n<p>Clarithromycin is a strong CYP3A4 inhibitor and dramatically raises levels of simvastatin and lovastatin \u2014 risk of severe muscle injury (rhabdomyolysis) and acute kidney injury. The statin should be paused for the antibiotic course or switched to a non-CYP3A4 statin (rosuvastatin, pravastatin).<\/p>\n<h3>What if I miss a dose?<\/h3>\n<p>Take it as soon as you remember. If you are within a few hours of the next dose, skip and resume. Do not double up.<\/p>\n<h3>Does Azee interact with my contraceptive pill?<\/h3>\n<p>Modern evidence does not support clinically important reductions in pill efficacy. Continue your usual schedule. Use additional protection if you experience vomiting or diarrhoea.<\/p>\n<h3>Can I drink alcohol?<\/h3>\n<p>There is no direct interaction. Heavy drinking increases nausea and slows immune recovery \u2014 moderate use is acceptable.<\/p>\n<h3>Will Azee cover MRSA?<\/h3>\n<p>No \u2014 most MRSA strains are macrolide-resistant via efflux pumps and target modifications. For MRSA, use clindamycin \/ doxycycline \/ TMP-SMX \/ linezolid based on local susceptibility data.<\/p>\n<h3>Why did my doctor give me a single 1 g dose for chlamydia?<\/h3>\n<p>Azithromycin 1 g single oral dose achieves curative tissue levels for >7 days against Chlamydia trachomatis. Confirmed treatment failure rates are low (~5%); test of cure is recommended at 3 months because re-infection is common.<\/p>\n<h3>Can I use this for a viral cold?<\/h3>\n<p>No. Macrolides have no antiviral activity. Using them for the common cold or simple flu provides no benefit, accelerates resistance, and exposes you to QT and GI side effects unnecessarily.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Other Antibiotics &amp; Anti-Infective Medications<\/h2>\n<ul>\n<li><a href=\"\/azee\/\">Azee (Azithromycin) \u2014 short-course macrolide alternative<\/a><\/li>\n<li><a href=\"\/claribid\/\">Claribid (Clarithromycin) \u2014 H. pylori, atypical pneumonia<\/a><\/li>\n<li><a href=\"\/doxt\/\">Doxt (Doxycycline) \u2014 atypical pneumonia \/ STIs<\/a><\/li>\n<li><a href=\"\/augmentin\/\">Augmentin (Amoxicillin + Clavulanic acid) \u2014 beta-lactam alternative<\/a><\/li>\n<li><a href=\"\/levomac\/\">Levomac (Levofloxacin) \u2014 respiratory fluoroquinolone<\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:22px 0 0;border-radius:6px;font-size:13px;color:#555;\"><strong>Medical Disclaimer:<\/strong> The information on this page is provided for educational purposes and does not replace a consultation with a qualified clinician. Antibiotic resistance is a serious global health issue \u2014 use antibiotics only for confirmed bacterial infections, complete the full prescribed course, and never share or save leftover doses. Always check for personal allergies, drug interactions, and dose adjustments before starting therapy.<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u2705 Powerful Antibacterial Agent<br \/>\n\u2705 Treats Various Infections<br \/>\n\u2705 Promotes Quick Recovery<br \/>\n\u2705 Easy to Consume<br \/>\n\u2705 Minimal Side Effects<\/p>\n","protected":false},"featured_media":52351,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3484,3141,3342],"product_tag":[],"class_list":{"0":"post-52350","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-antibiotics","7":"product_cat-category-overview","8":"product_cat-general-health","10":"first","11":"outofstock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable","15":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product\/52350","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/comments?post=52350"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/media\/52351"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/media?parent=52350"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product_brand?post=52350"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product_cat?post=52350"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product_tag?post=52350"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}