{"id":55317,"date":"2024-01-30T10:07:16","date_gmt":"2024-01-30T10:07:16","guid":{"rendered":"https:\/\/medsname.com\/agoprex\/"},"modified":"2026-04-30T10:24:49","modified_gmt":"2026-04-30T10:24:49","slug":"agoprex","status":"publish","type":"product","link":"https:\/\/medsbase.com\/hu\/product\/agoprex\/","title":{"rendered":"Agoprex"},"content":{"rendered":"

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\u26a1 Gyors v\u00e1lasz<\/h3>\n

Az Agoprex (Agomelatine 25 mg) egy melatonin MT1\/MT2 receptor agonist \u00e9s 5-HT2C antagonista a s\u00falyos depresszi\u00f3 kezel\u00e9s\u00e9re. K\u00fcl\u00f6nleges profil: nincs szexu\u00e1lis diszfunkci\u00f3, s\u00falygyarapod\u00e1s vagy abbahagy\u00e1si szindr\u00f3ma, de k\u00f6telez\u0151 m\u00e1jfunkci\u00f3 monitoroz\u00e1s.<\/p>\n<\/div>\n

\nMit kapsz a MedsBase-n\u00e1l:<\/strong> WHO-GMP min\u0151s\u00edt\u00e9s\u0171 gy\u00e1rt\u00f3 \u00b7 Diszkr\u00e9t csomagol\u00e1s \u00b7 Vil\u00e1gszerte sz\u00e1ll\u00edt\u00e1s \u00b7 1.400+ hiteles\u00edtett v\u00e1s\u00e1rl\u00f3i v\u00e9lem\u00e9ny<\/a>\n<\/div>\n

\ud83d\udce6 Minden rendel\u00e9st fedez a \u00dajrak\u00fcld\u00e9si Garancia<\/strong><\/a> \u2014 ha a csomagod nem \u00e9rkezik meg 20 munkanapon bel\u00fcl, \u00fajrak\u00fcldj\u00fck.<\/p>\n

Mi\u00e9rt rendelj a MedsBase-r\u00f3l<\/h3>\n

Az Agoprex a MedsBase-n\u00e1l k\u00f6zvetlen\u00fcl WHO-GMP min\u0151s\u00edt\u00e9s\u0171 gy\u00e1rt\u00f3t\u00f3l sz\u00e1rmazik, egyszer\u0171, diszkr\u00e9t csomagol\u00e1sban. Minden rendel\u00e9sre terjed ki a \u00dajrak\u00fcld\u00e9si Garancia<\/a> \u2014 20 \u00fczleti napos \u00e9rkez\u00e9si ablak vagy ingyenes \u00fajrasz\u00e1ll\u00edt\u00e1s \u2014 \u00e9s jogosult a mi h\u0171s\u00e9gprogramunkra<\/a>. .<\/p>\n

Loyalty programme<\/h2>\n

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Worldwide shipping is available to most destinations.<\/p>\n

What Agoprex is and how it works<\/h2>\n\n\n\n\n\n\n
Agoprex is a 25 mg agomelatine tablet supplied by Sun Pharma. Agomelatine is mechanistically unique among antidepressants: it acts as an agonist at melatonin MT1 and MT2 receptors and an antagonist at 5-HT2C serotonin receptors. The dual mechanism resynchronises disrupted circadian rhythms (a feature of major depression) while indirectly increasing dopamine and noradrenaline release in the frontal cortex.<\/th>\nAgomelatine has no SERT activity, no anticholinergic effects, and no histaminergic effects \u2014 explaining its very different side-effect profile from SSRIs and TCAs.<\/th>\nIndications and dosing<\/th>\nIndication<\/th>\n<\/tr>\n<\/thead>\n
Starting<\/td>\nTarget<\/td>\nTarget<\/td>\nMax<\/td>\n<\/tr>\n
Major depression<\/td>\n25 mg HS csak<\/td>\n\u2014<\/td>\nne n\u00f6velje<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Mindig este bev\u00e9ve (cs\u00facs\u00e9rt\u00e9k 1 \u00f3ra m\u00falva, felez\u00e9si id\u0151 1\u20132 \u00f3ra, de a cirkadi\u00e1n ritmust befoly\u00e1sol\u00f3 receptorhat\u00e1s miatt esti id\u0151z\u00edt\u00e9s sz\u00fcks\u00e9ges).<\/p>\n

Fontos biztons\u00e1gi megfontol\u00e1sok<\/h2>\n
\nK\u00f6telez\u0151 m\u00e1jm\u0171k\u00f6d\u00e9si vizsg\u00e1latok<\/strong><\/p>\n

Az agomelatin klinikailag jelent\u0151s hepatotoxicit\u00e1si jelet mutat \u2013 ritka esetekben fulmin\u00e1ns hepatitis is el\u0151fordulhat. K\u00f6telez\u0151 m\u00e1jm\u0171k\u00f6d\u00e9si vizsg\u00e1latok<\/strong> alapvizsg\u00e1latkor, majd 3, 6, 12 \u00e9s 24 h\u00e9tenk\u00e9nt, valamint minden d\u00f3zisemel\u00e9skor. Azonnal sz\u00fcneteltetni, ha az AST vagy ALT > 3\u00d7 ULN, vagy ha s\u00e1rgas\u00e1g, s\u00f6t\u00e9t vizelet, jobb fels\u0151 kvadr\u00e1ns f\u00e1jdalom vagy f\u00e1radts\u00e1g m\u00e1jk\u00e1rosod\u00e1sra utal. Ellenjavallt minden el\u0151re fenn\u00e1ll\u00f3 m\u00e1jk\u00e1rosod\u00e1s eset\u00e9n<\/strong> (Child-Pugh B vagy C), ha az alapvizsg\u00e1latn\u00e1l a transzamin\u00e1zok > 3\u00d7 ULN, valamint er\u0151s alkoholfogyaszt\u00e1s mellett.<\/p>\n<\/div>\n

\nGy\u00f3gyszerinterakci\u00f3k \u2013 er\u0151s CYP1A2 g\u00e1tl\u00f3k<\/strong><\/p>\n

Ker\u00fclje a fluvoxamin, ciprofloxacin, enoxacin egyidej\u0171 haszn\u00e1lat\u00e1t \u2013 ezek t\u00f6bbsz\u00f6r\u00f6s\u00e9re n\u00f6velik az agomelatin szintj\u00e9t. A doh\u00e1nyz\u00e1s abbahagy\u00e1sa szintemelked\u00e9st okozhat (a CYP1A2 induk\u00e1l\u00f3dik doh\u00e1nyz\u00e1s hat\u00e1s\u00e1ra).<\/p>\n<\/div>\n

\n\u00d6ngyilkoss\u00e1gi kock\u00e1zat fekete doboz figyelmeztet\u00e9s (25 \u00e9v alattiak)<\/strong><\/p>\n

Minden antidepressz\u00e1ns hordoz FDA fekete doboz figyelmeztet\u00e9st a 25 \u00e9v alatti betegekn\u00e9l fokozott \u00f6ngyilkoss\u00e1gi gondolatok kock\u00e1zat\u00e1ra vonatkoz\u00f3an.<\/p>\n<\/div>\n

Gyakori mell\u00e9khat\u00e1sok<\/h2>\n