{"id":55590,"date":"2024-02-07T05:32:09","date_gmt":"2024-02-07T05:32:09","guid":{"rendered":"https:\/\/medsname.com\/atomoxet\/"},"modified":"2026-04-30T10:24:46","modified_gmt":"2026-04-30T10:24:46","slug":"atomoxet","status":"publish","type":"product","link":"https:\/\/medsbase.com\/atomoxet\/","title":{"rendered":"Atomoxet"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div class=\"medsbase-tldr-answer\" style=\"background:#fff8d6;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">\u26a1 Quick Answer<\/h3>\n<p style=\"margin-bottom:0;\">Atomoxet (Atomoxetine 10 \/ 18 \/ 25 \/ 40 \/ 60 \/ 80 mg) is a selective noradrenaline reuptake inhibitor for ADHD in children, adolescents, and adults. Non-stimulant \u2014 no abuse potential, no controlled-substance scheduling. Useful when stimulants are unsuitable, ineffective, or contraindicated.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>What you get with MedsBase:<\/strong> WHO-GMP certified manufacturer \u00b7 Discreet packaging \u00b7 Worldwide shipping \u00b7 1,400+ verified <a href=\"https:\/\/medsbase.com\/reviews\/\">customer reviews<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Every order is covered by our <a href=\"https:\/\/medsbase.com\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 if your parcel does not arrive within 20 business days, we reship it.<\/p>\n<h3>Why order from MedsBase<\/h3>\n<p>Atomoxet at MedsBase is supplied directly from a WHO-GMP certified manufacturer in plain, discreet packaging. Every order is covered by our <a href=\"https:\/\/medsbase.com\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance Policy<\/a> \u2014 20-business-day arrival window or we reship at no charge \u2014 and qualifies for our <a href=\"https:\/\/medsbase.com\/loyalty-points\/\">customer loyalty programme<\/a>. Worldwide shipping is available to most destinations.<\/p>\n<h2>What Atomoxet is and how it works<\/h2>\n<p>Atomoxet is a 10 \/ 18 \/ 25 \/ 40 \/ 60 \/ 80 mg atomoxetine capsule supplied by Intas. Atomoxetine selectively inhibits the noradrenaline reuptake transporter (NET), increasing synaptic noradrenaline and \u2014 indirectly via cortical NA-DA crosstalk \u2014 frontal-cortex dopamine, without affecting striatal dopamine. The latter is what differentiates atomoxetine from stimulants: no euphoria, no abuse potential, no controlled-substance scheduling.<\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Slow onset \u2014 not a same-day medication<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Stimulants work within 30\u201360 minutes of the first dose. Atomoxetine takes 2\u20134 weeks for initial response and 8\u201312 weeks for full effect. Patients (and parents) expecting stimulant-like immediate change will be disappointed and discontinue. Set the expectation at initiation.<\/p>\n<\/div>\n<h2>Indications and dosing<\/h2>\n<table>\n<thead>\n<tr>\n<th>Patient<\/th>\n<th>Starting<\/th>\n<th>Target<\/th>\n<th>Max<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Children &amp; adolescents \u2264 70 kg<\/td>\n<td>0.5 mg\/kg\/day \u00d7 3 d<\/td>\n<td>1.2 mg\/kg\/day<\/td>\n<td>1.4 mg\/kg or 100 mg<\/td>\n<\/tr>\n<tr>\n<td>Children &amp; adolescents &gt; 70 kg<\/td>\n<td>40 mg OD \u00d7 3 d<\/td>\n<td>80 mg OD<\/td>\n<td>100 mg OD<\/td>\n<\/tr>\n<tr>\n<td>Adults<\/td>\n<td>40 mg OD \u00d7 7 d<\/td>\n<td>80 mg OD<\/td>\n<td>100 mg<\/td>\n<\/tr>\n<tr>\n<td>Strong CYP2D6 inhibitor \/ poor metaboliser<\/td>\n<td>0.5 mg\/kg or 40 mg<\/td>\n<td>0.5 \u00d7 normal target<\/td>\n<td>by tolerability<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Can be given once daily morning or split BID (morning + late afternoon \u2014 avoid evening because of insomnia).<\/p>\n<h2>Important safety considerations<\/h2>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Suicidality black-box (paediatric)<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Atomoxetine carries an FDA black-box warning for increased suicidal ideation in children and adolescents, particularly in the first month and at dose changes. Monitor closely for behaviour change in paediatric patients on initiation.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Hepatotoxicity \u2014 rare<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Rare cases of severe hepatic injury have been reported. Stop immediately if jaundice, dark urine, RUQ pain, fatigue, or unexplained nausea appear. Do not restart after definite hepatic injury.<\/p>\n<\/div>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Cardiovascular<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Atomoxetine produces small mean increases in BP (+2 mmHg) and HR (+5 bpm). Greater rises occasionally seen in adults. Check BP and HR at baseline, at each dose change, and at follow-up. Avoid in serious cardiac structural abnormality, severe cardiovascular disease, or pheochromocytoma.<\/p>\n<\/div>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Growth (paediatric)<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Mild reductions in growth velocity reported in children on atomoxetine \u2014 usually catch up over time. Plot height and weight at every visit.<\/p>\n<\/div>\n<h2>Common side effects<\/h2>\n<ul>\n<li><strong>GI:<\/strong> nausea, vomiting, abdominal pain, decreased appetite, dyspepsia \u2014 most prominent first 1\u20132 weeks.<\/li>\n<li><strong>CNS:<\/strong> headache, somnolence or insomnia, dizziness, mood lability.<\/li>\n<li><strong>Cardiovascular:<\/strong> small BP and HR rise.<\/li>\n<li><strong>Sexual:<\/strong> erectile difficulty, ejaculation disorders in adult men.<\/li>\n<li><strong>GU:<\/strong> urinary hesitancy.<\/li>\n<li><strong>Distinctive negatives:<\/strong> no abuse potential, no euphoria, no rebound, no tics. Useful when stimulants worsen tics or anxiety.<\/li>\n<\/ul>\n<h2>Drug interactions<\/h2>\n<ul>\n<li><strong>MAOIs<\/strong> \u2014 absolute contraindication; 14-day washout each direction.<\/li>\n<li><strong>Strong CYP2D6 inhibitors<\/strong> (paroxetine, fluoxetine, bupropion, quinidine) \u2014 significantly raise atomoxetine levels; halve dose or switch.<\/li>\n<li><strong>Pressor agents \/ other sympathomimetics<\/strong> \u2014 additive cardiovascular effects.<\/li>\n<li><strong>Other QT-prolonging drugs<\/strong> \u2014 small additive risk.<\/li>\n<\/ul>\n<h2>Pregnancy, breastfeeding, paediatric<\/h2>\n<p>Pregnancy category C \u2014 limited data. Breastfeeding: insufficient data. Paediatric: licensed from age 6, with the suicidality black-box.<\/p>\n<h2>Storage<\/h2>\n<p>Store at 15\u201330 \u00b0C in original packaging.<\/p>\n<h2 id=\"faqs\">Frequently Asked Questions<\/h2>\n<h3>How is Atomoxet different from a stimulant?<\/h3>\n<p>Atomoxetine is non-stimulant, non-controlled, with no abuse potential and no euphoria. The trade-off: slower onset (weeks rather than minutes), generally smaller effect size in trials, and a different side-effect profile (more GI, less appetite suppression, less insomnia, no rebound).<\/p>\n<h3>How long until Atomoxet works?<\/h3>\n<p>Some response by week 2\u20134; full effect at 8\u201312 weeks. If there is no response after 12 weeks at 1.2\u20131.4 mg\/kg or 80\u2013100 mg, switch.<\/p>\n<h3>Can Atomoxet be used with a stimulant?<\/h3>\n<p>Yes \u2014 combination is described under specialist supervision when monotherapy is partial. Cardiovascular monitoring is more important.<\/p>\n<h3>Why doesn&rsquo;t Atomoxet need refrigeration or controlled-substance dispensing?<\/h3>\n<p>Atomoxetine is not a controlled substance in any major jurisdiction \u2014 no scheduling, no special prescription, no pharmacy storage requirements. This makes it convenient for travel and for patients in workplaces with drug-testing regimes (it does not produce stimulant metabolites on standard urine screens).<\/p>\n<h3>Will Atomoxet affect appetite or weight?<\/h3>\n<p>Mild appetite suppression \u2014 much less than stimulants. Most adults and children maintain normal weight; mild weight loss in some.<\/p>\n<h3>Can Atomoxet be taken in the morning only?<\/h3>\n<p>Yes \u2014 once-daily morning dosing is the most common pattern. The pharmacokinetic half-life is approximately 5 hours but the clinical effect persists much longer because of receptor-level changes. Some patients prefer split BID dosing for symptom coverage; clinician choice.<\/p>\n<h3>Can Atomoxet cause sexual side effects?<\/h3>\n<p>Yes \u2014 particularly in adult men, ejaculation disorders and erectile dysfunction are reported in 5\u201310%. Less common than SSRIs.<\/p>\n<h3>Can Atomoxet be used in adults with anxiety?<\/h3>\n<p>Useful when ADHD coexists with anxiety \u2014 atomoxetine&rsquo;s noradrenergic action can be either anxiolytic (long-term) or anxiogenic (initial weeks). Stimulants tend to worsen anxiety, atomoxetine often does not.<\/p>\n<h3>Can I stop Atomoxet abruptly?<\/h3>\n<p>Yes \u2014 atomoxetine has minimal withdrawal because of its short half-life. Most patients stop directly without taper.<\/p>\n<h3>Will Atomoxet show up on drug tests?<\/h3>\n<p>No \u2014 atomoxetine does not produce stimulant metabolites and does not show on standard amphetamine or methylphenidate workplace screens.<\/p>\n<h2>Other Mental Health Medications<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/agoprex\/\">Agoprex (Agomelatine \u2014 adult comorbid depression)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/lexaheal\/\">Lexaheal (Escitalopram \u2014 comorbid anxiety)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bupron-xl\/\">Bupron XL (Bupropion \u2014 NDRI; off-label ADHD adjunct)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/flunil\/\">Flunil (Fluoxetine SSRI)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/mirtaz\/\">Mirtaz (Mirtazapine NaSSA)<\/a><\/li>\n<\/ul>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;font-size:0.9em;\">\n<strong>Medical disclaimer.<\/strong> This page is educational and is not a substitute for individualised medical advice. Mental-health pharmacotherapy should be initiated, monitored, and adjusted under a qualified clinician. If you or someone you know is in suicidal crisis, contact local emergency services immediately, or call your country&rsquo;s suicide-prevention helpline (US\/Canada: 988; UK: Samaritans 116 123; international list: <a href=\"https:\/\/findahelpline.com\/\" rel=\"nofollow noopener\" target=\"_blank\">findahelpline.com<\/a>).\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Atomoxet (Atomoxetine 10\u201380 mg) \u2014 selective NA reuptake inhibitor (NRI) for ADHD in children, adolescents and adults. non-stimulant, non-controlled \u2014 slow onset 2\u20134 weeks.<\/p>\n","protected":false},"featured_media":55591,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3906],"product_tag":[3951,3952],"class_list":{"0":"post-55590","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-mental-health-and-psychiatric-medications","9":"product_tag-atomoxet","10":"product_tag-atomoxetine","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product\/55590","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/comments?post=55590"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/media\/55591"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/media?parent=55590"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product_brand?post=55590"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product_cat?post=55590"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product_tag?post=55590"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}