{"id":55626,"date":"2024-02-07T05:33:41","date_gmt":"2024-02-07T05:33:41","guid":{"rendered":"https:\/\/medsname.com\/avana\/"},"modified":"2026-05-01T10:49:12","modified_gmt":"2026-05-01T10:49:12","slug":"avana","status":"publish","type":"product","link":"https:\/\/medsbase.com\/avana\/","title":{"rendered":"Avana"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Avana?<\/h3>\n<p style=\"margin:0;\"><strong>Avana<\/strong> contains <strong>avanafil<\/strong> and is used for erectile dysfunction. Available in <strong>50 \/ 100 \/ 200 mg<\/strong>. Clinical effect lasts around <strong>4 to 5 hours (onset as fast as 15 minutes)<\/strong>. Manufactured by Sunrise Remedies.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>What you get with MedsBase:<\/strong> WHO-GMP certified manufacturer \u00b7 Discreet packaging \u00b7 Worldwide shipping \u00b7 1,400+ verified <a href=\"https:\/\/medsbase.com\/reviews\/\">customer reviews<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Every order is covered by our <a href=\"https:\/\/medsbase.com\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 if your parcel does not arrive within 20 business days, we reship it.<\/p>\n<h3>Why order from MedsBase<\/h3>\n<p>Our generic medications are sourced from WHO-GMP certified manufacturers and shipped worldwide in discreet, plain packaging \u2014 no medication name on the parcel exterior. Card payments are routed through a regulated processor (statement descriptors include a regulated card-payment processor \u2014 never &ldquo;MedsBase&rdquo; or any medication name). Crypto and SEPA bank transfer are also accepted. Every order is backed by our Reshipment Assurance Policy.<\/p>\n<p><strong>Avana<\/strong> is an <strong>avanafil<\/strong> tablet for the treatment of <strong>erectile dysfunction<\/strong>. Avanafil is the <strong>fastest-onset PDE5 inhibitor<\/strong> currently on the market \u2014 effects can begin within 15 minutes, well ahead of sildenafil, tadalafil, or vardenafil.<\/p>\n<p>Manufactured by Sunrise Remedies, Avana contains the same active ingredient as Menarini&#8217;s branded <strong>Stendra<sup>&reg;<\/sup><\/strong> (or <strong>Spedra<sup>&reg;<\/sup><\/strong> in Europe) at a lower price. It is a second-generation PDE5 inhibitor designed to deliver the response of its predecessors with less side-effect burden and more flexible timing.<\/p>\n<h2 class=\"wp-block-heading\">What Is Avana?<\/h2>\n<p>Avana is a prescription PDE5 inhibitor, FDA-approved in 2012, with a clinical profile optimized for <strong>rapid onset and a cleaner side-effect profile<\/strong>. It is highly selective for PDE5 over PDE6 (the retinal enzyme) and PDE11, which is thought to explain its lower rate of visual and musculoskeletal side effects.<\/p>\n<p>Avana is used for:<\/p>\n<ul>\n<li><strong>Erectile dysfunction of any cause<\/strong><\/li>\n<li><strong>Men who need rapid onset<\/strong> \u2014 avanafil can work in as little as 15 minutes<\/li>\n<li><strong>Men who have had side effects with other PDE5 inhibitors<\/strong> \u2014 often tolerated when sildenafil or tadalafil aren&#8217;t<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">How Does Avana Work?<\/h2>\n<p>Avanafil shares the core PDE5-inhibition mechanism with other drugs in its class:<\/p>\n<ul>\n<li>Sexual stimulation releases <strong>nitric oxide<\/strong> in penile tissue<\/li>\n<li>NO activates <strong>guanylate cyclase<\/strong>, raising cyclic GMP<\/li>\n<li>cGMP relaxes arterial smooth muscle, increasing inflow and trapping blood in the erectile bodies<\/li>\n<li>PDE5 normally degrades cGMP, ending the erection<\/li>\n<li><strong>Avanafil blocks PDE5<\/strong>, prolonging the response<\/li>\n<\/ul>\n<p>What distinguishes avanafil is its pharmacokinetic profile: time to peak plasma ~30\u201345 minutes, and meaningful effect within <strong>15 minutes<\/strong> in many patients. Its half-life is about 5 hours, so the clinical window is 4\u20135 hours.<\/p>\n<p>Avanafil is <strong>highly selective for PDE5<\/strong> versus PDE6 and PDE11 \u2014 which is why visual side effects (blue tinge, photosensitivity seen with sildenafil) and muscle aches (common with tadalafil) are less frequent.<\/p>\n<h2 class=\"wp-block-heading\">Uses and Indications<\/h2>\n<ul>\n<li><strong>Erectile dysfunction<\/strong> \u2014 first-line PDE5 option, FDA-approved since 2012<\/li>\n<li><strong>Men needing rapid, on-demand response<\/strong><\/li>\n<li><strong>Men intolerant of other PDE5 inhibitors<\/strong><\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Avana Dosage and Administration<\/h2>\n<table>\n<thead>\n<tr>\n<th>Scenario<\/th>\n<th>Recommended Dose<\/th>\n<th>Frequency \/ Timing<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>ED \u2014 starter dose<\/strong><\/td>\n<td>100 mg<\/td>\n<td>15\u201330 min before activity; max 1 dose \/ 24 h<\/td>\n<\/tr>\n<tr>\n<td><strong>ED \u2014 lower sensitivity<\/strong><\/td>\n<td>50 mg<\/td>\n<td>For men with side effects at 100 mg<\/td>\n<\/tr>\n<tr>\n<td><strong>ED \u2014 inadequate response<\/strong><\/td>\n<td>200 mg<\/td>\n<td>Maximum single dose; step up after 2\u20133 adequate 100 mg trials<\/td>\n<\/tr>\n<tr>\n<td><strong>Elderly (65+)<\/strong><\/td>\n<td>Standard dose<\/td>\n<td>No routine reduction unless organ impairment<\/td>\n<\/tr>\n<tr>\n<td><strong>Mild\u2013moderate hepatic impairment<\/strong><\/td>\n<td>50 mg<\/td>\n<td>Use with caution<\/td>\n<\/tr>\n<tr>\n<td><strong>Severe renal or hepatic impairment<\/strong><\/td>\n<td>Not recommended<\/td>\n<td>Avoid<\/td>\n<\/tr>\n<tr>\n<td><strong>Maximum daily dose<\/strong><\/td>\n<td>200 mg<\/td>\n<td>On-demand only \u2014 not licensed for daily dosing<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3 class=\"wp-block-heading\">How to Take Avana Properly<\/h3>\n<ul>\n<li>Swallow whole with water \u2014 can be taken with or without food (though a heavy meal may slow onset slightly)<\/li>\n<li>Allow 15\u201330 minutes before intended activity \u2014 one of avanafil&#8217;s strongest selling points<\/li>\n<li>Do not exceed one dose per 24 hours<\/li>\n<li>Avoid grapefruit juice<\/li>\n<li>Limit alcohol to 1\u20132 drinks<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Side Effects of Avana<\/h2>\n<p>Avanafil has one of the cleanest side-effect profiles in the PDE5 class.<\/p>\n<table>\n<thead>\n<tr>\n<th>Severity<\/th>\n<th>Side Effect<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Common<\/strong><\/td>\n<td>Headache, facial flushing, nasal congestion<\/td>\n<\/tr>\n<tr>\n<td><strong>Less common than with sildenafil<\/strong><\/td>\n<td>Visual disturbance (rare \u2014 avanafil has low PDE6 activity), musculoskeletal pain<\/td>\n<\/tr>\n<tr>\n<td><strong>Uncommon<\/strong><\/td>\n<td>Dizziness, dyspepsia, back pain, palpitations<\/td>\n<\/tr>\n<tr>\n<td><strong>Rare<\/strong><\/td>\n<td>Priapism, sudden vision loss (NAION), sudden hearing loss<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Warnings and Precautions<\/h2>\n<ul>\n<li><strong>Cardiovascular fitness for sex<\/strong> \u2014 sexual activity places cardiac demand on the heart. Men with active angina, recent MI (within 90 days), uncontrolled arrhythmia, or severe heart failure should have a cardiac assessment before starting a PDE5 inhibitor<\/li>\n<li><strong>Blood pressure<\/strong> \u2014 PDE5 inhibitors cause mild, transient reductions in BP; use with caution if taking multiple antihypertensives<\/li>\n<li><strong>Priapism<\/strong> \u2014 higher risk in men with sickle-cell disease, multiple myeloma, or leukaemia; seek urgent care if an erection lasts more than 4 hours<\/li>\n<li><strong>Vision<\/strong> \u2014 discontinue and seek review if sudden visual changes occur; rare cases of non-arteritic anterior ischaemic optic neuropathy (NAION) have been reported<\/li>\n<li><strong>Hearing<\/strong> \u2014 rare reports of sudden sensorineural hearing loss \u2014 stop and consult a doctor if affected<\/li>\n<li><strong>Alcohol<\/strong> \u2014 significant alcohol intake combined with any PDE5 inhibitor can compound dizziness, headache, and low blood pressure<\/li>\n<li><strong>Grapefruit juice<\/strong> \u2014 inhibits CYP3A4 and can raise blood levels<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Contraindications &mdash; Who Should NOT Take This Medication<\/h2>\n<ul>\n<li><strong>Concurrent use of any nitrate<\/strong> \u2014 GTN, isosorbide mono\/dinitrate, nicorandil, amyl nitrite (&#8220;poppers&#8221;)<\/li>\n<li><strong>Concurrent use of guanylate cyclase stimulators<\/strong> such as riociguat<\/li>\n<li>Recent heart attack (within 90 days), unstable angina, or angina during intercourse<\/li>\n<li>NYHA Class II or greater heart failure within the last 6 months<\/li>\n<li>Uncontrolled arrhythmia, hypotension (BP &lt;90\/50) or uncontrolled hypertension (BP &gt;170\/100)<\/li>\n<li>Stroke within the last 6 months<\/li>\n<li>Known non-arteritic anterior ischaemic optic neuropathy (NAION) in one or both eyes<\/li>\n<li>Severe hepatic impairment (Child-Pugh C)<\/li>\n<li>Hypersensitivity to the active ingredient or any excipient<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Drug Interactions<\/h2>\n<table>\n<thead>\n<tr>\n<th>Drug \/ Class<\/th>\n<th>Interaction<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Nitrates (GTN, ISMN, ISDN, amyl nitrite\/&#8221;poppers&#8221;)<\/strong><\/td>\n<td><strong>Absolute contraindication<\/strong> \u2014 severe, potentially fatal hypotension<\/td>\n<\/tr>\n<tr>\n<td><strong>Alpha-blockers (doxazosin, tamsulosin, alfuzosin)<\/strong><\/td>\n<td>Additive blood-pressure lowering \u2014 stabilise alpha-blocker dose first, start at lowest PDE5 dose<\/td>\n<\/tr>\n<tr>\n<td><strong>CYP3A4 inhibitors (ketoconazole, itraconazole, ritonavir, clarithromycin)<\/strong><\/td>\n<td>Raise PDE5 plasma levels \u2014 reduce dose or avoid combination<\/td>\n<\/tr>\n<tr>\n<td><strong>CYP3A4 inducers (rifampicin, phenytoin, carbamazepine, St John&#8217;s wort)<\/strong><\/td>\n<td>Lower PDE5 plasma levels \u2014 efficacy may be reduced<\/td>\n<\/tr>\n<tr>\n<td><strong>Riociguat and other sGC stimulators<\/strong><\/td>\n<td>Contraindicated \u2014 severe hypotension risk<\/td>\n<\/tr>\n<tr>\n<td><strong>Other PDE5 inhibitors<\/strong><\/td>\n<td>Do not combine \u2014 additive side effects without extra efficacy<\/td>\n<\/tr>\n<tr>\n<td><strong>Antihypertensives<\/strong><\/td>\n<td>Small additive BP reduction \u2014 usually clinically insignificant<\/td>\n<\/tr>\n<tr>\n<td><strong>Grapefruit juice<\/strong><\/td>\n<td>Inhibits CYP3A4 \u2014 avoid large or regular intake<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Always share a full list of your current medications, including over-the-counter products, recreational drugs, and herbal supplements, with your prescriber before starting this medication.<\/p>\n<h2 class=\"wp-block-heading\">What to Do in Case of Overdose<\/h2>\n<p>Symptoms of a PDE5 overdose include severe headache, marked hypotension, dizziness, back or muscle pain, and prolonged erection. Management is supportive, with fluid resuscitation and cardiac monitoring. Contact your local poisons service or emergency department immediately if an overdose is suspected.<\/p>\n<h2 class=\"wp-block-heading\">Storage Instructions<\/h2>\n<ul>\n<li>Store below 30&nbsp;&deg;C in a dry place, away from direct sunlight<\/li>\n<li>Keep in the original blister packaging until use<\/li>\n<li>Keep out of reach of children and pets<\/li>\n<li>Do not use after the expiry date printed on the pack<\/li>\n<li>Dispose of unused tablets via a pharmacy take-back scheme where available<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Related Alternatives on MedsBase<\/h2>\n<p>Looking for related ED or sexual-health treatment options?<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/modula\/\" rel=\"noopener\">Modula<\/a> &mdash; tadalafil 5 mg, ideal for once-daily low-dose therapy<\/li>\n<li><a href=\"https:\/\/medsbase.com\/vidalista\/\" rel=\"noopener\">Vidalista<\/a> &mdash; Centurion Labs tadalafil, 2.5 to 80 mg<\/li>\n<li><a href=\"https:\/\/medsbase.com\/tadacip\/\" rel=\"noopener\">Tadacip<\/a> &mdash; Cipla tadalafil 20 mg<\/li>\n<li><a href=\"https:\/\/medsbase.com\/megalis\/\" rel=\"noopener\">Megalis<\/a> &mdash; Macleods tadalafil 10 mg \/ 20 mg<\/li>\n<li><a href=\"https:\/\/medsbase.com\/suhagra\/\" rel=\"noopener\">Suhagra<\/a> &mdash; Cipla sildenafil 25\/50\/100 mg<\/li>\n<li><a href=\"https:\/\/medsbase.com\/erectile-dysfunction\/\" rel=\"noopener\">Browse all Erectile Dysfunction treatments &rarr;<\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">Frequently Asked Questions<\/h2>\n<h3 class=\"wp-block-heading\">How fast does Avana work?<\/h3>\n<p>Avanafil is the <strong>fastest-onset PDE5 inhibitor<\/strong> \u2014 effects can begin within 15 minutes and are usually reliable by 30 minutes. This is significantly faster than sildenafil, tadalafil, or vardenafil.<\/p>\n<h3 class=\"wp-block-heading\">How long does Avana last?<\/h3>\n<p>The clinical window is about <strong>4\u20135 hours<\/strong>. Half-life is ~5 hours.<\/p>\n<h3 class=\"wp-block-heading\">Why would I choose Avana over sildenafil?<\/h3>\n<p>Three reasons: (1) <strong>speed<\/strong> \u2014 15-min onset, (2) <strong>selectivity<\/strong> \u2014 far fewer visual side effects than sildenafil, (3) <strong>timing flexibility<\/strong> \u2014 food has less impact on absorption than with sildenafil.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Avana with food?<\/h3>\n<p>Yes \u2014 food has less impact than with sildenafil. A heavy meal may slightly delay onset, but the effect is modest.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Avana every day?<\/h3>\n<p>No \u2014 avanafil is on-demand only. For a once-daily schedule, tadalafil 5 mg (e.g. <a href=\"https:\/\/medsbase.com\/modula\/\" rel=\"noopener\">Modula<\/a>) is the licensed option.<\/p>\n<h3 class=\"wp-block-heading\">Is Avana safer than older PDE5 inhibitors?<\/h3>\n<p>Avanafil has a cleaner side-effect profile thanks to its high PDE5 selectivity, but the class-wide contraindications (nitrates, recent MI, unstable angina) still apply.<\/p>\n<h3 class=\"wp-block-heading\">Does Avana work for men who failed sildenafil?<\/h3>\n<p>Some non-responders do respond to avanafil. If sildenafil has been given 2\u20133 adequate trials with no effect, switching is worth trying \u2014 avanafil, tadalafil, and vardenafil each have distinct receptor-binding profiles.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol with Avana?<\/h3>\n<p>Limit to 1\u20132 drinks. Heavy alcohol adds to vasodilation and dizziness.<\/p>\n<h3 class=\"wp-block-heading\">Is Avana safe with heart conditions?<\/h3>\n<p>Contraindicated with any nitrate, within 90 days of MI, or in unstable angina. Discuss your cardiac status with a doctor before starting.<\/p>\n<h3 class=\"wp-block-heading\">What&#8217;s the maximum dose of Avana?<\/h3>\n<p>200 mg on-demand. Most men respond well to the 100 mg starter dose \u2014 step up only after 2\u20133 adequate 100 mg trials with a clear response gap.<\/p>\n<p><!-- medsbase-faq-h3-converted --><\/p>\n<p data-mb-link-target=\"malegra-fxt\" style=\"margin-top:1em;font-size:0.95em;color:#444;border-left:3px solid #2c7cb0;padding:0.5em 0.75em;background:#f4f8fb;\"><strong>See also:<\/strong> <a href=\"https:\/\/medsbase.com\/malegra-fxt\/\"><strong>Malegra FXT<\/strong><\/a> \u2014 Sunrise Remedies dual ED+PE tablet pairing sildenafil 100 mg with fluoxetine 40 mg in one daily dose.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Related Alternatives<\/h3>\n<p>Other products in <strong>Men&#039;s Health<\/strong> that customers also view:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ladygra\/\">Ladygra<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/super-p-force-oral-jelly\/\">Super P-Force Oral Jelly<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/tamsuheal\/\">Tamsuheal<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/dutanol\/\">Dutanol<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/caverta\/\">Caverta<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u2705 Enhances erectile function<br \/>\n\u2705 Improves sexual performance<br \/>\n\u2705 Increases blood flow<br \/>\n\u2705 Treats erectile dysfunction<br \/>\n\u2705 Enhances sexual satisfaction<\/p>\n<p>Avana contains Avanafil.<\/p>\n","protected":false},"featured_media":55627,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[3141,3143,3142],"product_tag":[3146,3147,5635,5652,5637,5651,5650],"class_list":{"0":"post-55626","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-erectile-dysfunction","8":"product_cat-mens-health","9":"product_tag-avana","10":"product_tag-avanafil","11":"product_tag-erectile-dysfunction","12":"product_tag-fast-onset","13":"product_tag-pde5-inhibitor","14":"product_tag-spedra","15":"product_tag-stendra-generic","17":"first","18":"instock","19":"shipping-taxable","20":"purchasable","21":"product-type-variable","22":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product\/55626","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/comments?post=55626"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/media\/55627"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/media?parent=55626"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product_brand?post=55626"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product_cat?post=55626"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product_tag?post=55626"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}