{"id":55973,"date":"2024-02-07T05:47:52","date_gmt":"2024-02-07T05:47:52","guid":{"rendered":"https:\/\/medsname.com\/tegrital\/"},"modified":"2026-05-01T10:49:13","modified_gmt":"2026-05-01T10:49:13","slug":"tegrital","status":"publish","type":"product","link":"https:\/\/medsbase.com\/hu\/product\/tegrital\/","title":{"rendered":"Tegrital 100 mg r\u00e1g\u00f3tabletta (Karbamazepin) \u2014 trigeminus neuralgia \u00e9s rohamok"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 28px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;font-size:18px;color:#1a1a1a;\">Gyors v\u00e1lasz<\/h3>\n<p><strong>Tegrital 100 mg chewable tablets<\/strong> tartalmaz <strong>carbamazepine<\/strong>, a sodium-channel-blocking anticonvulsant that has been first-line for <strong>trigeminal neuralgia since 1962<\/strong> and remains a workhorse anti-epileptic for partial-onset seizures and bipolar mood stabilisation. The chewable formulation is well-suited to children, patients with swallowing difficulty, and adults who prefer not to swallow whole tablets. Treatment starts low (100 mg once or twice daily) and titrates up slowly because carbamazepine induces its own metabolism over 2\u20134 weeks. <strong>Asian-ancestry patients should be tested for HLA-B*1502 before starting<\/strong> \u2014 this allele identifies a high risk of Stevens-Johnson syndrome.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Mit kapsz a MedsBase-n\u00e1l:<\/strong> WHO-GMP min\u0151s\u00edt\u00e9s\u0171 gy\u00e1rt\u00f3 \u00b7 Diszkr\u00e9t csomagol\u00e1s \u00b7 Vil\u00e1gszerte sz\u00e1ll\u00edt\u00e1s \u00b7 1.400+ hiteles\u00edtett <a href=\"https:\/\/medsbase.com\/hu\/reviews\/\">v\u00e1s\u00e1rl\u00f3i v\u00e9lem\u00e9ny<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Minden rendel\u00e9st fedez a <a href=\"https:\/\/medsbase.com\/hu\/medsbase-re-shipment-assurance-policy\/\"><strong>\u00dajrak\u00fcld\u00e9si Garancia<\/strong><\/a> \u2014 ha a csomagod nem \u00e9rkezik meg 20 munkanapon bel\u00fcl, \u00fajrak\u00fcldj\u00fck.<\/p>\n<h3>Mi\u00e9rt rendelj a MedsBase-r\u00f3l<\/h3>\n<p>Generikus gy\u00f3gyszereink WHO-GMP min\u0151s\u00edt\u00e9s\u0171 gy\u00e1rt\u00f3kt\u00f3l sz\u00e1rmaznak, \u00e9s diszkr\u00e9t, egyszer\u0171 csomagol\u00e1sban sz\u00e1ll\u00edtjuk \u0151ket vil\u00e1gszerte \u2014 a csomagon nem szerepel a gy\u00f3gyszer neve. A k\u00e1rty\u00e1s fizet\u00e9sek egy szab\u00e1lyozott feldolgoz\u00f3n kereszt\u00fcl t\u00f6rt\u00e9nnek (a sz\u00e1mlale\u00edr\u00e1sok egy szab\u00e1lyozott k\u00e1rtyafizet\u00e9si feldolgoz\u00f3t tartalmaznak \u2014 soha nem \u201cMedsBase\u201d vagy b\u00e1rmilyen gy\u00f3gyszer neve). Kriptovalut\u00e1t \u00e9s SEPA banki \u00e1tutal\u00e1st is elfogadunk. Minden rendel\u00e9st a Reshipment Assurance Policy biztos\u00edt\u00e9k fedez.<\/p>\n<h2>What Is Tegrital?<\/h2>\n<p>Tegrital is an Indian-manufactured generic of <strong>carbamazepine<\/strong>, available as a 100 mg chewable tablet. Carbamazepine is a tricyclic compound structurally related to imipramine but pharmacologically classified as an anti-epileptic. The chewable formulation can be chewed, broken, or swallowed whole with water \u2014 convenient for children and patients with dysphagia.<\/p>\n<h2>How Carbamazepine Works<\/h2>\n<p>Carbamazepine binds <strong>voltage-gated sodium channels<\/strong> in their inactivated state, preventing the channel from returning to its resting state and so blocking repetitive high-frequency neuronal firing while sparing normal physiological signalling. This mechanism explains its efficacy in:<\/p>\n<ul>\n<li><strong>Focal (partial) seizures<\/strong> \u2014 sustained suppression of epileptogenic firing<\/li>\n<li><strong>Trigeminusneuralgia<\/strong> \u2014 blocks paroxysmal nerve discharges in the trigeminal ganglion<\/li>\n<li><strong>Mood stabilisation<\/strong> \u2014 reduces neuronal excitability and limbic hyperactivity<\/li>\n<\/ul>\n<h2>Indik\u00e1ci\u00f3k<\/h2>\n<ul>\n<li><strong>Trigeminusneuralgia<\/strong> \u2014 first-line per NICE, EFNS, and AAN guidelines<\/li>\n<li><strong>Partial-onset seizures<\/strong> with or without secondary generalisation<\/li>\n<li><strong>Generalised tonic-clonic seizures<\/strong> \u2014 second-line<\/li>\n<li><strong>Bipolar disorder<\/strong> \u2014 mood stabiliser, particularly mixed and rapid-cycling presentations<\/li>\n<li><strong>Glossopharyngeal neuralgia<\/strong> \u2014 analogous use to trigeminal neuralgia<\/li>\n<li><strong>Diabetic neuropathy<\/strong> \u2014 second-line option when gabapentinoids fail or are contraindicated<\/li>\n<li><strong>Alcohol withdrawal<\/strong> \u2014 selected cases under specialist supervision<\/li>\n<\/ul>\n<h2>Adagol\u00e1s \u00e9s alkalmaz\u00e1s<\/h2>\n<table>\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th>Agoprex is a 25 mg agomelatine tablet supplied by Sun Pharma. Agomelatine is mechanistically unique among antidepressants: it acts as an agonist at melatonin MT1 and MT2 receptors and an antagonist at 5-HT2C serotonin receptors. The dual mechanism resynchronises disrupted circadian rhythms (a feature of major depression) while indirectly increasing dopamine and noradrenaline release in the frontal cortex.<\/th>\n<th>Agomelatine has no SERT activity, no anticholinergic effects, and no histaminergic effects \u2014 explaining its very different side-effect profile from SSRIs and TCAs.<\/th>\n<th>Titr\u00e1l\u00e1s<\/th>\n<th>Karbantart\u00f3 adag<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Trigeminusneuralgia<\/td>\n<td>100 mg once or twice daily<\/td>\n<td>+100\u2013200 mg every 2 days<\/td>\n<td>200\u2013400 mg three times daily<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td>Partial seizures (adult)<\/td>\n<td>100\u2013200 mg once or twice daily<\/td>\n<td>+100\u2013200 mg weekly<\/td>\n<td>800\u20131200 mg\/day in 2\u20134 doses<\/td>\n<\/tr>\n<tr>\n<td>Bipolar disorder<\/td>\n<td>200 mg naponta k\u00e9tszer<\/td>\n<td>+200 mg every 3\u20134 days<\/td>\n<td>400\u20131600 mg\/day<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td>Children (epilepsy)<\/td>\n<td>10\u201320 mg\/kg\/day<\/td>\n<td>Szakmai \u00fatmutat\u00e1s<\/td>\n<td>15\u201330 mg\/kg\/day in divided doses<\/td>\n<\/tr>\n<tr>\n<td>Id\u0151s<\/td>\n<td>100 mg naponta k\u00e9tszer<\/td>\n<td>Cautious titration<\/td>\n<td>Lower of typical adult range<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>HLA-B*1502 testing before starting<\/strong> Patients of Han Chinese, Thai, Malay, Vietnamese, Filipino, Indonesian, and South Indian ancestry have a much higher carrier rate of HLA-B*1502 \u2014 an allele strongly associated with Stevens-Johnson syndrome and toxic epidermal necrolysis on carbamazepine. Test before initiation in these populations and choose an alternative if positive. HLA-A*3101 is a similar but lower-risk marker in European and Japanese ancestry.<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>Ter\u00e1pi\u00e1s gy\u00f3gyszerszint-monitoroz\u00e1s<\/strong> Aim for a steady-state plasma level of 4\u201312 mg\/L (17\u201351 \u00b5mol\/L). Carbamazepine is a potent autoinducer \u2014 your daily requirement may rise over the first 2\u20134 weeks of treatment as hepatic CYP3A4 induction matures. Levels should be checked 5\u20137 days after each dose change.<\/div>\n<h2>Gyakori mell\u00e9khat\u00e1sok<\/h2>\n<ul>\n<li>Drowsiness, ataxia (especially during titration)<\/li>\n<li>Dizziness, blurred or double vision<\/li>\n<li>H\u00e1nyinger, h\u00e1ny\u00e1s<\/li>\n<li>Fejf\u00e1j\u00e1s<\/li>\n<li>Mild rash (\u22485\u201310% of patients)<\/li>\n<li>Dry mouth, mild fluid retention<\/li>\n<li>Hyponatraemia (mild, especially in elderly)<\/li>\n<\/ul>\n<h2>Serious Side Effects \u2014 Stop and Seek Care<\/h2>\n<ul>\n<li><strong>Severe rash, blistering, mouth ulcers<\/strong> \u2014 possible Stevens-Johnson syndrome \/ TEN<\/li>\n<li><strong>Aplastic anaemia, agranulocytosis<\/strong> \u2014 full blood count monitoring during the first months<\/li>\n<li><strong>Hyponatraemia &lt;125 mmol\/L<\/strong> \u2014 confusion, seizures<\/li>\n<li><strong>Hepatitis<\/strong> \u2014 jaundice, dark urine, abdominal pain<\/li>\n<li><strong>DRESS syndrome<\/strong> \u2014 fever, lymphadenopathy, eosinophilia, multi-organ involvement<\/li>\n<li>Heart block (rare)<\/li>\n<li>Suicidal ideation (anti-epileptic class warning)<\/li>\n<\/ul>\n<h2>Ellenjavallatok<\/h2>\n<ul>\n<li>Known hypersensitivity to carbamazepine, oxcarbazepine, or tricyclic antidepressants<\/li>\n<li>Atrioventricular block (especially second- or third-degree)<\/li>\n<li>History of bone-marrow depression or acute intermittent porphyria<\/li>\n<li>Use of MAO inhibitors within the previous 14 days<\/li>\n<li>HLA-B*1502 positive (relative \u2014 alternative agent preferred)<\/li>\n<\/ul>\n<h2>Gy\u00f3gyszerk\u00f6lcs\u00f6nhat\u00e1sok<\/h2>\n<p>Carbamazepine is a powerful inducer of CYP3A4 and many other CYP enzymes. It accelerates the metabolism (and so reduces the plasma level and clinical effect) of:<\/p>\n<ul>\n<li>Combined oral contraceptives \u2014 alternative contraception is essential<\/li>\n<li>Warfarin and direct oral anticoagulants<\/li>\n<li>Many other anti-epileptics (lamotrigine, valproate, phenytoin)<\/li>\n<li>Antiretrovirals, immunosuppressants, calcium-channel blockers<\/li>\n<li>Statins (especially simvastatin), corticosteroids<\/li>\n<\/ul>\n<p>And its own level is raised dangerously by:<\/p>\n<ul>\n<li>Makrolid antibiotikumok (eritromicin, klaritromicin)<\/li>\n<li>Diltiazem, verapamil, isoniazid, fluconazole, ketoconazole<\/li>\n<li>Grapefruitl\u00e9<\/li>\n<\/ul>\n<h2>T\u00e1rol\u00e1s<\/h2>\n<p>Store below 25 \u00b0C in a dry place. Protect from moisture (carbamazepine tablets can degrade in damp conditions). Keep in original blister packaging. Keep out of reach of children.<\/p>\n<h2 id=\"faqs\">Gyakran Ism\u00e9telt K\u00e9rd\u00e9sek<\/h2>\n<h3>Is Tegrital the same as Tegretol?<\/h3>\n<p>Yes \u2014 both are brand names for carbamazepine. Tegrital is the Indian generic version; Tegretol is the original Novartis brand. Mechanism, dosing, and effect are identical at the same dose.<\/p>\n<h3>How fast does carbamazepine work for trigeminal neuralgia?<\/h3>\n<p>Most patients experience meaningful pain relief within 24\u201372 hours of reaching an effective dose. The challenge is reaching that dose \u2014 slow titration is required to limit dizziness and ataxia. About 70% of trigeminal neuralgia patients respond at carbamazepine doses of 200\u2013800 mg\/day.<\/p>\n<h3>Why does the dose need to go up over time?<\/h3>\n<p>Carbamazepine induces its own hepatic metabolism \u2014 autoinduction. Over the first 2\u20134 weeks the liver produces more CYP3A4 enzyme, accelerating drug clearance. Daily requirements typically rise 30\u201360% before plateauing.<\/p>\n<h3>What is HLA-B*1502 testing and do I need it?<\/h3>\n<p>HLA-B*1502 is a genetic marker strongly associated with Stevens-Johnson syndrome on carbamazepine. The FDA recommends pre-treatment testing for patients of Han Chinese, Thai, Malay, South Indian, Filipino, Indonesian, and Vietnamese ancestry. If positive, an alternative anticonvulsant should be used.<\/p>\n<h3>Can carbamazepine be used in pregnancy?<\/h3>\n<p>Carbamazepine is associated with neural tube defects (1% risk vs. 0.06% baseline) and other malformations. It is generally avoided in pregnancy when alternatives exist. If continued, high-dose folic acid (5 mg daily) is recommended before conception and through the first trimester.<\/p>\n<h3>Does Tegrital interact with the contraceptive pill?<\/h3>\n<p>Yes \u2014 strongly. Carbamazepine reduces oestrogen and progestogen levels via CYP3A4 induction, leading to contraceptive failure. Use a copper IUD, levonorgestrel IUD, or progestogen-only injection during treatment.<\/p>\n<h3>How long until I can come off carbamazepine?<\/h3>\n<p>For trigeminal neuralgia, many patients trial dose reduction every 6\u201312 months once pain is controlled. For epilepsy, withdrawal is considered only after 2\u20133 years seizure-free. Always taper \u2014 abrupt stop can precipitate seizures even in patients without epilepsy.<\/p>\n<h3>Milyen v\u00e9rvizsg\u00e1latokra van sz\u00fcks\u00e9g?<\/h3>\n<p>Baseline full blood count, liver function, urea and electrolytes, and pregnancy test where relevant. Repeat FBC and LFTs at 4 weeks, 3 months, then every 6\u201312 months. Carbamazepine plasma level 5\u20137 days after each dose change.<\/p>\n<h3>Can I drink alcohol on Tegrital?<\/h3>\n<p>Avoid or strictly limit alcohol. Both carbamazepine and alcohol depress the central nervous system; combining them increases sedation, falls risk, and raises seizure threshold variability.<\/p>\n<h3>Why is Tegrital chewable?<\/h3>\n<p>The chewable format makes the tablet easy to take for children, elderly patients, and anyone with swallowing difficulty. The bioavailability is comparable to standard tablets.<\/p>\n<h3>Is Tegrital effective for fibromyalgia?<\/h3>\n<p>Carbamazepine is not first-line for fibromyalgia \u2014 pregabalin, duloxetine, and amitriptyline are. Carbamazepine has a defined role in trigeminal neuralgia and partial seizures; for general nerve pain it is a later-line option.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0;border-radius:4px;font-size:13px;\"><strong>Orvosi felel\u0151ss\u00e9gi nyilatkozat:<\/strong> Ez az oldal t\u00e1j\u00e9koztat\u00f3 jelleg\u0171, \u00e9s nem helyettes\u00edti a szakorvosi tan\u00e1csot. Mindig konzult\u00e1ljon k\u00e9pzett eg\u00e9szs\u00e9g\u00fcgyi szakemberrel, miel\u0151tt b\u00e1rmilyen gy\u00f3gyszert elkezdene, abbahagyna vagy m\u00f3dos\u00edtana, k\u00fcl\u00f6n\u00f6sen, ha m\u00e1s eg\u00e9szs\u00e9g\u00fcgyi probl\u00e9m\u00e1ja van, m\u00e1s gy\u00f3gyszert szed, terhes vagy szoptat, vagy 65 \u00e9v feletti.<\/div>\n<p class=\"medsbase-link-boost-2026-04-30\" data-marker=\"mb-link-boost-gabasign\">For trigeminal neuralgia patients who do not respond to or tolerate carbamazepine, <a href='\/hu\/gabasign\/'>Gabasign (gabapentin 100\/300\/400\/600\/800 mg)<\/a> is the standard second-line option per AAN\/EFNS guidelines and covers the broader range of neuropathic-pain indications.<\/p>\n<p data-mb-link-target=\"gabasign\" data-mb-anchor-variant=\"v2\" style=\"margin-top:1em;font-size:0.95em;color:#444;border-left:3px solid #2c7cb0;padding:0.5em 0.75em;background:#f4f8fb;\"><strong>L\u00e1sd m\u00e9g:<\/strong> <a href=\"https:\/\/medsbase.com\/hu\/gabasign\/\"><strong>the gabapentin brand we stock<\/strong><\/a> \u2014 Cipla gabapentin generikuma \u2014 ugyanaz az FDA \u00e1ltal j\u00f3v\u00e1hagyott molekula, teljes d\u00f3zistartom\u00e1ny 300 mg kezd\u0151d\u00f3zist\u00f3l 600 mg karbantart\u00f3 d\u00f3zisig.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Kapcsol\u00f3d\u00f3 alternat\u00edv\u00e1k<\/h3>\n<p>Egy\u00e9b term\u00e9kek a <strong>Kr\u00f3nikus betegs\u00e9gek<\/strong> v\u00e1s\u00e1rl\u00f3k \u00e1ltal szint\u00e9n megtekintett term\u00e9kek:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/hu\/calpol\/\">Calpol<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/abana\/\">Abana<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/symbicort-turbohaler\/\">Symbicort Turbohaler<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/monit\/\">Monit<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/caberlin\/\">Caberlin<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Controls seizures<br \/>\n\u2705 Bipol\u00e1ris zavar kezel\u00e9s\u00e9re<br \/>\n\u2705 Relieves nerve pain<br \/>\n\u2705 Manages trigeminal neuralgia<br \/>\n\u2705 Stabilizes mood<\/p>\n<p>Tegrital contains Carbamazepine.<\/p>","protected":false},"featured_media":55974,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3985],"product_tag":[4022,4023],"class_list":{"0":"post-55973","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-neuropathic-pain-medication","9":"product_tag-carbamazepine","10":"product_tag-tegrital","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product\/55973","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/comments?post=55973"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/media\/55974"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/media?parent=55973"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product_brand?post=55973"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product_cat?post=55973"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product_tag?post=55973"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}