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\ud83d\udca1 Quick Answer<\/strong><\/p>\n Progynova<\/strong> is an oral systemic estrogen<\/strong> (estradiol valerate) used for menopausal hormone therapy \u2014 treating hot flushes, night sweats, vaginal dryness, and bone-density loss. Women with an intact uterus must combine estrogen with a progestin<\/strong> (unopposed estrogen raises endometrial cancer risk ~8\u201315\u00d7). Short-term use (1\u20135 years) at the lowest effective dose is the modern standard; long-term risks include breast cancer, VTE, and stroke (Women’s Health Initiative data).<\/p>\n<\/div>\n \ud83d\udce6 Every order is covered by our Reshipment Assurance Policy<\/strong><\/a> \u2014 if your parcel does not arrive within 20 business days, we reship it.<\/p>\n Every MedsBase order ships from a WHO-GMP certified manufacturer in plain, fully discreet packaging \u2014 nothing on the outside identifies the contents or the pharmacy. Card payments run through a regulated crypto on-ramp; the statement descriptor on your bank record is the processor name (a regulated card-payment processor) \u2014 never \u201cMedsBase\u201d or anything pharmacy-related. Crypto payments via Plisio stay fully anonymous. Every parcel is covered by our Reshipment Assurance Policy<\/a>.<\/p>\n Progynova is a branded generic of estradiol valerate<\/strong>, a systemic oral estrogen used as menopausal hormone therapy (MHT \/ HRT)<\/strong>. Estrogen replaces the hormone lost after natural or surgical menopause, relieving the symptom cluster known as the climacteric syndrome<\/strong>.<\/p>\n Strengths: 1 mg, 2 mg (oral tablets, 28 or 56-tablet packs)<\/strong>. Manufactured by Bayer.<\/p>\n If you have a uterus, you must take estrogen combined with a progestin<\/strong>. Unopposed estrogen stimulates endometrial proliferation, raising endometrial cancer risk ~8\u201315\u00d7. Options:<\/p>\n Women who have had a hysterectomy<\/strong> can take estrogen alone without a progestin. See our progesterone products: Endogest<\/a>, Gestheal<\/a>, Susten Capsule<\/a>.<\/p>\n The Women’s Health Initiative (WHI) trials redefined HRT risk understanding. Key findings per 10,000 women per year of combined estrogen-progestin HRT:<\/p>\n Risk-benefit is most favourable in women under 60 with severe symptoms and no contraindications<\/strong>. Transdermal estrogen (patch, gel) may reduce VTE risk vs oral.<\/p>\n Common:<\/strong> breast tenderness, nausea, headache, fluid retention, mood changes, vaginal bleeding (normal in first 3\u20136 months of continuous-combined regimen).<\/p>\n Less common:<\/strong> melasma, gallstones, contact-lens intolerance, libido changes.<\/p>\n Serious (rare) \u2014 seek urgent care:<\/strong> chest pain, shortness of breath, severe leg swelling (VTE\/PE), sudden severe headache with neurological changes (stroke), breast lump, yellowing of skin\/eyes (liver problem), heavy or prolonged vaginal bleeding.<\/p>\n Store at room temperature (15\u201325 \u00b0C \/ 59\u201377 \u00b0F), away from moisture and direct light. Keep in original packaging. Keep out of reach of children.<\/p>\n Modern guidelines suggest starting HRT within 10 years of menopause onset or before age 60 (“window of opportunity”) for best cardiovascular safety profile. Starting HRT after age 65 has a less favourable risk-benefit ratio unless severe symptoms persist.<\/p>\n Yes \u2014 always. Unopposed estrogen raises endometrial cancer risk 8\u201315\u00d7. Take estrogen with micronized progesterone (endogest, gestheal, etc.), dydrogesterone, medroxyprogesterone, or a Mirena IUD.<\/p>\n Modern practice: lowest effective dose, shortest duration \u2014 typically 3\u20135 years, reviewed annually. Extended use is appropriate for severe symptoms, premature menopause, or osteoporosis; discussed on an individual basis.<\/p>\n Transdermal estrogen has a lower VTE risk (no first-pass hepatic effect) and is preferred for women with VTE risk factors, migraine, or hepatic concerns. Oral is convenient and well-studied but carries slightly higher thrombotic risk.<\/p>\n Estradiol (the molecule in Progynova) is bioidentical. Conjugated estrogens (Premarin) are not strictly bioidentical. Micronized progesterone is bioidentical. “Compounded bioidentical” custom-mixed products at non-standard doses have no proven advantage and often lack quality control \u2014 most gynaecology societies do not recommend them.<\/p>\n Risk depends on type and duration. Estrogen-only (women without uterus): no clear breast cancer risk increase over ~7 years in WHI. Combined estrogen-progestin: ~+8 cases per 10,000 women per year. Risk returns to baseline within 2\u20135 years of stopping.<\/p>\n Often \u2014 especially if vasomotor symptoms are disrupting sleep or causing irritability. HRT is not an antidepressant; severe mood symptoms may need separate treatment.<\/p>\n Weight gain is more commonly linked to the perimenopausal transition itself (shifting body composition, declining estrogen) than HRT. Modern low-dose HRT is typically weight-neutral.<\/p>\n Expected for 3\u20136 months on continuous-combined HRT. Withdrawal bleeding is expected on cyclic HRT. Unexpected or prolonged bleeding<\/strong> beyond 6 months needs clinical review (endometrial biopsy or ultrasound) to rule out endometrial hyperplasia or cancer.<\/p>\n For vasomotor symptoms: SSRIs\/SNRIs (paroxetine, venlafaxine), gabapentin, clonidine, cognitive-behavioural therapy, fezolinetant (newer neurokinin-3 antagonist). For genitourinary symptoms: vaginal moisturisers, lubricants, ospemifene. Discuss with a clinician.<\/p>\n \u2695\ufe0f Medical Disclaimer:<\/strong> Information is educational and does not replace medical advice. Hormone therapies carry specific risks (breast cancer, VTE, stroke, endometrial cancer if unopposed estrogen) \u2014 consult a clinician before starting, stopping, or changing any hormone medication. Individual risk\u2013benefit depends on personal and family medical history.<\/p>\n<\/div>\n <\/p>\n Other products in Women’s Health<\/strong> that customers also view:<\/p>\n \u2705 Hormone Replacement Therapy Progynova<\/strong> contains Estradiol<\/strong>.<\/p>\n","protected":false},"featured_media":56925,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[3141,3519,3502],"product_tag":[3527,4201],"class_list":{"0":"post-56924","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-hormone-replacement-therapy-hrt-medication-for-menopause","8":"product_cat-womens-health","9":"product_tag-estradiol","10":"product_tag-progynova","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product\/56924","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/comments?post=56924"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/media\/56925"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/media?parent=56924"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product_brand?post=56924"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product_cat?post=56924"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/wp-json\/wp\/v2\/product_tag?post=56924"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Why order from MedsBase<\/h3>\n
What Is Progynova?<\/strong><\/h2>\n
Clinical Uses<\/strong><\/h2>\n
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Critical: Progestin Opposition<\/strong><\/h2>\n
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How to Take<\/strong><\/h2>\n
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Risks and Safety (WHI and Follow-Up Evidence)<\/strong><\/h2>\n
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Side Effects<\/strong><\/h2>\n
Who Should Not Take Progynova<\/strong><\/h2>\n
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Drug Interactions<\/strong><\/h2>\n
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Storage<\/strong><\/h2>\n
Frequently Asked Questions<\/h2>\n
When should I start HRT?<\/h3>\n
Do I need a progestin if I have a uterus?<\/h3>\n
How long can I stay on HRT?<\/h3>\n
Is HRT safer as a patch or gel than a pill?<\/h3>\n
What about bioidentical hormones?<\/h3>\n
Will HRT cause breast cancer?<\/h3>\n
Will HRT help my mood or sleep?<\/h3>\n
Can HRT cause weight gain?<\/h3>\n
What should I do if I have vaginal bleeding on HRT?<\/h3>\n
What about non-hormonal alternatives?<\/h3>\n
Related Hormone & Women’s Health Products<\/h3>\n
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Related Alternatives<\/h3>\n
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\n\u2705 Manages Menopausal Symptoms
\n\u2705 Prevents Osteoporosis
\n\u2705 Prescribed by Gynecologists
\n\u2705 Improves Quality of Life<\/p>\n