{"id":56924,"date":"2024-02-27T17:14:41","date_gmt":"2024-02-27T17:14:41","guid":{"rendered":"https:\/\/medsname.com\/progynova\/"},"modified":"2026-04-30T10:17:16","modified_gmt":"2026-04-30T10:17:16","slug":"progynova","status":"publish","type":"product","link":"https:\/\/medsbase.com\/hu\/product\/progynova\/","title":{"rendered":"Progynova"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 8px 0;\"><strong>\ud83d\udca1 Gyors v\u00e1lasz<\/strong><\/p>\n<p style=\"margin:0;\"><strong>Progynova<\/strong> egy <strong>oral systemic estrogen<\/strong> (estradiol valerate) used for menopausal hormone therapy \u2014 treating hot flushes, night sweats, vaginal dryness, and bone-density loss. <strong>Women with an intact uterus must combine estrogen with a progestin<\/strong> (unopposed estrogen raises endometrial cancer risk ~8\u201315\u00d7). Short-term use (1\u20135 years) at the lowest effective dose is the modern standard; long-term risks include breast cancer, VTE, and stroke (Women&#8217;s Health Initiative data).<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Mit kapsz a MedsBase-n\u00e1l:<\/strong> WHO-GMP min\u0151s\u00edt\u00e9s\u0171 gy\u00e1rt\u00f3 \u00b7 Diszkr\u00e9t csomagol\u00e1s \u00b7 Vil\u00e1gszerte sz\u00e1ll\u00edt\u00e1s \u00b7 1.400+ hiteles\u00edtett <a href=\"https:\/\/medsbase.com\/hu\/reviews\/\">v\u00e1s\u00e1rl\u00f3i v\u00e9lem\u00e9ny<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Minden rendel\u00e9st fedez a <a href=\"https:\/\/medsbase.com\/hu\/medsbase-re-shipment-assurance-policy\/\"><strong>\u00dajrak\u00fcld\u00e9si Garancia<\/strong><\/a> \u2014 ha a csomagod nem \u00e9rkezik meg 20 munkanapon bel\u00fcl, \u00fajrak\u00fcldj\u00fck.<\/p>\n<div style=\"background:#f4f8fb;border-left:4px solid #2c7cb0;padding:14px 20px;margin:16px 0;border-radius:4px;font-size:0.95em;\">\n<strong>\ud83d\udd12 Amit a MedsBase ny\u00fajt:<\/strong> WHO-GMP min\u0151s\u00edt\u00e9s\u0171 gy\u00e1rt\u00f3 \u00b7 Diszkr\u00e9t egyszer\u0171 csomagol\u00e1s (a gy\u00f3gyszer neve nincs k\u00edv\u00fcl felt\u00fcntetve) \u00b7 Vil\u00e1gszerte sz\u00e1ll\u00edt\u00e1s \u00b7 Olvassa el a <a href=\"https:\/\/medsbase.com\/hu\/reviews\/\">1,400+ v\u00e1s\u00e1rl\u00f3i v\u00e9lem\u00e9ny<\/a>\n<\/div>\n<h3>Mi\u00e9rt rendelj a MedsBase-r\u00f3l<\/h3>\n<p>Minden MedsBase rendel\u00e9st WHO-GMP min\u0151s\u00edt\u00e9s\u0171 gy\u00e1rt\u00f3t\u00f3l sz\u00e1ll\u00edtunk egyszer\u0171, teljesen diszkr\u00e9t csomagol\u00e1sban \u2014 semmi a csomag k\u00fcls\u0151 r\u00e9sz\u00e9n nem azonos\u00edtja a tartalmat vagy a gy\u00f3gyszert\u00e1rat. A k\u00e1rty\u00e1s fizet\u00e9sek egy szab\u00e1lyozott kripto-\u00e1tj\u00e1r\u00f3n kereszt\u00fcl futnak; a banksz\u00e1mlakivonaton a feldolgoz\u00f3 neve jelenik meg (egy szab\u00e1lyozott k\u00e1rtyafizet\u00e9si feldolgoz\u00f3) \u2014 soha nem \u201cMedsBase\u201d vagy b\u00e1rmi gy\u00f3gyszert\u00e1rral kapcsolatos. A kriptofizet\u00e9sek a Plisio-n kereszt\u00fcl teljesen n\u00e9vtelenek. Minden csomagot fedez a <a href=\"https:\/\/medsbase.com\/hu\/medsbase-re-shipment-assurance-policy\/\">\u00dajrak\u00fcld\u00e9si Garancia<\/a>.<\/p>\n<h2><strong>What Is Progynova?<\/strong><\/h2>\n<p>Progynova is a branded generic of <strong>estradiol valerate<\/strong>, a systemic oral estrogen used as <strong>menopausal hormone therapy (MHT \/ HRT)<\/strong>. Estrogen replaces the hormone lost after natural or surgical menopause, relieving the symptom cluster known as the <strong>climacteric syndrome<\/strong>.<\/p>\n<p>Strengths: <strong>1 mg, 2 mg (oral tablets, 28 or 56-tablet packs)<\/strong>. Manufactured by Bayer.<\/p>\n<h2><strong>Klinikai alkalmaz\u00e1s<\/strong><\/h2>\n<ul>\n<li><strong>Vasomotor symptoms<\/strong> (hot flushes, night sweats) \u2014 most effective treatment available, ~75\u201390% reduction in trials.<\/li>\n<li><strong>Menopauz\u00e1lis genitourin\u00e1ris szindr\u00f3ma<\/strong> \u2014 vaginal dryness, dyspareunia, recurrent UTIs. Vaginal estrogen is preferred for symptoms limited to the genitourinary tract.<\/li>\n<li><strong>Posztmenopaus\u00e1lis osteoporosis megel\u0151z\u00e9se<\/strong> \u2014 reduces fracture risk by ~30\u201350% with extended use. No longer first-line when bisphosphonates or denosumab are indicated.<\/li>\n<li><strong>Premature ovarian insufficiency (POI)<\/strong> \u2014 physiological replacement in women under 40 with premature menopause.<\/li>\n<li><strong>Female-to-male \u2192 female gender-affirming hormone therapy<\/strong> (off-label on this site; specialist-guided).<\/li>\n<\/ul>\n<h2><strong>Critical: Progestin Opposition<\/strong><\/h2>\n<p><strong>If you have a uterus, you must take estrogen combined with a progestin<\/strong>. Unopposed estrogen stimulates endometrial proliferation, raising endometrial cancer risk ~8\u201315\u00d7. Options:<\/p>\n<ul>\n<li><strong>Combined continuous<\/strong> \u2014 estrogen daily + progestin daily (no withdrawal bleed after 3\u20136 months)<\/li>\n<li><strong>Sequential (cyclic)<\/strong> \u2014 estrogen daily + progestin 10\u201314 days per month (withdrawal bleed each cycle)<\/li>\n<li><strong>Mirena IUD<\/strong> \u2014 delivers local progestin to the endometrium; allows estrogen monotherapy elsewhere<\/li>\n<\/ul>\n<p><strong>Women who have had a hysterectomy<\/strong> can take estrogen alone without a progestin. See our progesterone products: <a href=\"https:\/\/medsbase.com\/hu\/endogest\/\">Endogest<\/a>, <a href=\"https:\/\/medsbase.com\/hu\/gestheal\/\">Gestheal<\/a>, <a href=\"https:\/\/medsbase.com\/hu\/susten-capsule\/\">Susten kapszula<\/a>.<\/p>\n<h2><strong>Hogyan alkalmazand\u00f3<\/strong><\/h2>\n<ol>\n<li>Take one tablet once daily, at roughly the same time each day, with water. With or without food.<\/li>\n<li>Start at the lowest effective dose \u2014 typically 0.3 mg conjugated estrogens or 0.5\u20131 mg estradiol \u2014 and titrate up only if symptoms are incompletely controlled after 4\u20136 weeks.<\/li>\n<li>If cycle-regimen is used, the progestin is taken for the last 10\u201314 days of each 28-day cycle; withdrawal bleeding is expected.<\/li>\n<li>For continuous-combined regimen, take both hormones daily; irregular bleeding may occur for the first 3\u20136 months.<\/li>\n<li><strong>Use the lowest effective dose for the shortest effective duration.<\/strong> Review annually with a clinician. Most guidelines recommend discontinuation after 3\u20135 years.<\/li>\n<\/ol>\n<h2><strong>Risks and Safety (WHI and Follow-Up Evidence)<\/strong><\/h2>\n<p>The Women&#8217;s Health Initiative (WHI) trials redefined HRT risk understanding. Key findings per 10,000 women per year of combined estrogen-progestin HRT:<\/p>\n<ul>\n<li><strong>Eml\u0151r\u00e1k:<\/strong> +8 cases (with progestin); estrogen alone did not raise breast cancer risk over ~7 years in WHI<\/li>\n<li><strong>Stroke:<\/strong> +8 strokes<\/li>\n<li><strong>VTE (DVT\/PE):<\/strong> +18 events \u2014 highest risk in first year; oral &gt; transdermal<\/li>\n<li><strong>Coronary heart disease:<\/strong> +7 events in older HRT starters (60+), but possibly protective in younger starters (&lt;60)<\/li>\n<li><strong>Hip fracture:<\/strong> \u22125 (protective)<\/li>\n<li><strong>Colorectal cancer:<\/strong> \u22126 (protective, combined HRT)<\/li>\n<li><strong>Endometrial cancer:<\/strong> +1 (lower with progestin opposition)<\/li>\n<\/ul>\n<p>Risk-benefit is most favourable in <strong>women under 60 with severe symptoms and no contraindications<\/strong>. Transdermal estrogen (patch, gel) may reduce VTE risk vs oral.<\/p>\n<h2><strong>Mell\u00e9khat\u00e1sok<\/strong><\/h2>\n<p><strong>Gyakori:<\/strong> breast tenderness, nausea, headache, fluid retention, mood changes, vaginal bleeding (normal in first 3\u20136 months of continuous-combined regimen).<\/p>\n<p><strong>Kevesebb gyakoris\u00e1ggal:<\/strong> melasma, gallstones, contact-lens intolerance, libido changes.<\/p>\n<p><strong>Serious (rare) \u2014 seek urgent care:<\/strong> chest pain, shortness of breath, severe leg swelling (VTE\/PE), sudden severe headache with neurological changes (stroke), breast lump, yellowing of skin\/eyes (liver problem), heavy or prolonged vaginal bleeding.<\/p>\n<h2><strong>Who Should Not Take Progynova<\/strong><\/h2>\n<ul>\n<li>Current, suspected, or history of breast cancer or estrogen-dependent cancer<\/li>\n<li>Current or history of VTE (DVT, PE), thrombophilia, active thromboembolic disease<\/li>\n<li>History of stroke, TIA, or recent MI<\/li>\n<li>Active liver disease or cholestatic jaundice history (with previous pregnancy or estrogen use)<\/li>\n<li>Diagnosztiz\u00e1latlan h\u00fcvelyi v\u00e9rz\u00e9s<\/li>\n<li>Known pregnancy<\/li>\n<li>Endometrial hyperplasia (investigate first)<\/li>\n<li>Ismert t\u00fal\u00e9rz\u00e9kenys\u00e9g<\/li>\n<\/ul>\n<h2><strong>Gy\u00f3gyszerk\u00f6lcs\u00f6nhat\u00e1sok<\/strong><\/h2>\n<ul>\n<li><strong>Enzyme inducers<\/strong> (rifampicin, phenytoin, carbamazepine, St John&#8217;s Wort) reduce estrogen levels \u2014 higher-dose estrogen or alternative route may be needed.<\/li>\n<li><strong>Thyroxine (levothyroxine)<\/strong>: estrogen raises thyroid-binding globulin, may increase thyroxine requirement.<\/li>\n<li><strong>Varfarin<\/strong>: estrogen reduces warfarin effect slightly; monitor INR.<\/li>\n<li><strong>Grapefruitl\u00e9<\/strong>: may raise estrogen levels modestly.<\/li>\n<\/ul>\n<h2><strong>T\u00e1rol\u00e1s<\/strong><\/h2>\n<p>Store at room temperature (15\u201325 \u00b0C \/ 59\u201377 \u00b0F), away from moisture and direct light. Keep in original packaging. Keep out of reach of children.<\/p>\n<h2 id=\"faqs\">Gyakran Ism\u00e9telt K\u00e9rd\u00e9sek<\/h2>\n<h3 class=\"wp-block-heading\">When should I start HRT?<\/h3>\n<p>Modern guidelines suggest starting HRT within 10 years of menopause onset or before age 60 (&#8220;window of opportunity&#8221;) for best cardiovascular safety profile. Starting HRT after age 65 has a less favourable risk-benefit ratio unless severe symptoms persist.<\/p>\n<h3 class=\"wp-block-heading\">Do I need a progestin if I have a uterus?<\/h3>\n<p>Yes \u2014 always. Unopposed estrogen raises endometrial cancer risk 8\u201315\u00d7. Take estrogen with micronized progesterone (endogest, gestheal, etc.), dydrogesterone, medroxyprogesterone, or a Mirena IUD.<\/p>\n<h3 class=\"wp-block-heading\">How long can I stay on HRT?<\/h3>\n<p>Modern practice: lowest effective dose, shortest duration \u2014 typically 3\u20135 years, reviewed annually. Extended use is appropriate for severe symptoms, premature menopause, or osteoporosis; discussed on an individual basis.<\/p>\n<h3 class=\"wp-block-heading\">Is HRT safer as a patch or gel than a pill?<\/h3>\n<p>Transdermal estrogen has a lower VTE risk (no first-pass hepatic effect) and is preferred for women with VTE risk factors, migraine, or hepatic concerns. Oral is convenient and well-studied but carries slightly higher thrombotic risk.<\/p>\n<h3 class=\"wp-block-heading\">What about bioidentical hormones?<\/h3>\n<p>Estradiol (the molecule in Progynova) is bioidentical. Conjugated estrogens (Premarin) are not strictly bioidentical. Micronized progesterone is bioidentical. &#8220;Compounded bioidentical&#8221; custom-mixed products at non-standard doses have no proven advantage and often lack quality control \u2014 most gynaecology societies do not recommend them.<\/p>\n<h3 class=\"wp-block-heading\">Will HRT cause breast cancer?<\/h3>\n<p>Risk depends on type and duration. Estrogen-only (women without uterus): no clear breast cancer risk increase over ~7 years in WHI. Combined estrogen-progestin: ~+8 cases per 10,000 women per year. Risk returns to baseline within 2\u20135 years of stopping.<\/p>\n<h3 class=\"wp-block-heading\">Will HRT help my mood or sleep?<\/h3>\n<p>Often \u2014 especially if vasomotor symptoms are disrupting sleep or causing irritability. HRT is not an antidepressant; severe mood symptoms may need separate treatment.<\/p>\n<h3 class=\"wp-block-heading\">Can HRT cause weight gain?<\/h3>\n<p>Weight gain is more commonly linked to the perimenopausal transition itself (shifting body composition, declining estrogen) than HRT. Modern low-dose HRT is typically weight-neutral.<\/p>\n<h3 class=\"wp-block-heading\">What should I do if I have vaginal bleeding on HRT?<\/h3>\n<p>Expected for 3\u20136 months on continuous-combined HRT. Withdrawal bleeding is expected on cyclic HRT. <strong>Unexpected or prolonged bleeding<\/strong> beyond 6 months needs clinical review (endometrial biopsy or ultrasound) to rule out endometrial hyperplasia or cancer.<\/p>\n<h3 class=\"wp-block-heading\">What about non-hormonal alternatives?<\/h3>\n<p>For vasomotor symptoms: SSRIs\/SNRIs (paroxetine, venlafaxine), gabapentin, clonidine, cognitive-behavioural therapy, fezolinetant (newer neurokinin-3 antagonist). For genitourinary symptoms: vaginal moisturisers, lubricants, ospemifene. Discuss with a clinician.<\/p>\n<h3 class=\"wp-block-heading\">Kapcsol\u00f3d\u00f3 hormon- \u00e9s n\u0151i eg\u00e9szs\u00e9gterm\u00e9kek<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/hu\/premarin\/\">Premarin (Konjug\u00e1lt \u00f6sztrog\u00e9nek)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/premarin-cream\/\">Premarin kr\u00e9m (Vagin\u00e1lis \u00f6sztrog\u00e9n)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/endogest\/\">Endogest (Progeszteron 100 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/gestoford\/\">Gestoford (Progeszteron 100 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/gestheal\/\">Gestheal (Progeszteron 200 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/susten-capsule\/\">Susten kapszula (Progeszteron)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/susten-injection\/\">Susten injekci\u00f3 (Progeszteron)<\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 20px;margin:16px 0;border-radius:4px;font-size:0.9em;\">\n<p style=\"margin:0;\"><strong>\u2695\ufe0f Orvosi nyilatkozat:<\/strong> Az inform\u00e1ci\u00f3 t\u00e1j\u00e9koztat\u00f3 jelleg\u0171, \u00e9s nem helyettes\u00edti az orvosi tan\u00e1csot. A hormonkezel\u00e9sek specifikus kock\u00e1zatokkal j\u00e1rnak (eml\u0151r\u00e1k, v\u00e9n\u00e1s thromboembolia, stroke, endometriumr\u00e1k \u00f6sztrog\u00e9n-monoter\u00e1pi\u00e1n\u00e1l) \u2013 minden hormon\u00e1lis gy\u00f3gyszer szed\u00e9se el\u0151tt, abbahagy\u00e1sa el\u0151tt vagy m\u00f3dos\u00edt\u00e1sa el\u0151tt konzult\u00e1ljon klinikussal. Az egy\u00e9ni kock\u00e1zat-haszon ar\u00e1ny f\u00fcgg a szem\u00e9lyes \u00e9s csal\u00e1di eg\u00e9szs\u00e9g\u00fcgyi el\u0151zm\u00e9nyekt\u0151l.<\/p>\n<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Kapcsol\u00f3d\u00f3 alternat\u00edv\u00e1k<\/h3>\n<p>Egy\u00e9b term\u00e9kek a <strong>N\u0151k Eg\u00e9szs\u00e9ge<\/strong> v\u00e1s\u00e1rl\u00f3k \u00e1ltal szint\u00e9n megtekintett term\u00e9kek:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/hu\/candifem-vaginal-cream\/\">Candifem Vaginal Cream<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/yasmin\/\">Yasmin<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/cb-lin\/\">Cb-Lin<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/gestheal\/\">Gestheal<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/danogen\/\">Danogen<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Hormone Replacement Therapy<br \/>\n\u2705 Manages Menopausal Symptoms<br \/>\n\u2705 Prevents Osteoporosis<br \/>\n\u2705 Prescribed by Gynecologists<br \/>\n\u2705 Jav\u00edtja az \u00e9letmin\u0151s\u00e9get<\/p>\n<p>Progynova contains Estradiol.<\/p>","protected":false},"featured_media":56925,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3519,3502],"product_tag":[3527,4201],"class_list":{"0":"post-56924","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-hormone-replacement-therapy-hrt-medication-for-menopause","8":"product_cat-womens-health","9":"product_tag-estradiol","10":"product_tag-progynova","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product\/56924","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/comments?post=56924"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/media\/56925"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/media?parent=56924"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product_brand?post=56924"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product_cat?post=56924"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product_tag?post=56924"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}