{"id":58199,"date":"2024-02-27T18:22:57","date_gmt":"2024-02-27T18:22:57","guid":{"rendered":"https:\/\/medsname.com\/l-glutathione\/"},"modified":"2026-04-30T10:24:17","modified_gmt":"2026-04-30T10:24:17","slug":"l-glutathione","status":"publish","type":"product","link":"https:\/\/medsbase.com\/hu\/product\/l-glutathione\/","title":{"rendered":"L-Glutathione"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">Gyors v\u00e1lasz<\/h3>\n<p><strong>L-Glutathione (reduced glutathione (GSH) oral \/ IV)<\/strong> is reduced glutathione &mdash; the major intracellular antioxidant tripeptide. It is used as adjunctive therapy in chemotherapy-induced peripheral neuropathy, in non-alcoholic fatty liver disease (NAFLD), and as a supportive antioxidant in oxidative-stress conditions.<\/p>\n<ul style=\"margin-bottom:0;\">\n<li>Reduced glutathione (L-glutathione, GSH) &mdash; the major intracellular antioxidant<\/li>\n<li>Indications: cisplatin \/ oxaliplatin neuropathy, NAFLD, oxidative liver stress, autism (research only)<\/li>\n<li>Oral capsule or IV (specialist setting)<\/li>\n<li>WHO-GMP tan\u00fas\u00edtott gy\u00e1rt\u00f3<\/li>\n<\/ul>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f6f8;border:1px solid #e0e4e7;padding:12px 16px;margin:18px 0;border-radius:4px;font-size:14px;color:#444;\">\n<strong>WHO-GMP tan\u00fas\u00edtott gy\u00e1rt\u00f3<\/strong> \u00b7 Diszkr\u00e9t csomagol\u00e1s \u00b7 Vil\u00e1gszerte sz\u00e1ll\u00edt\u00e1s \u00b7 <a href=\"https:\/\/medsbase.com\/hu\/reviews\/\" style=\"color:#2c7cb0;\">1400+ hiteles\u00edtett v\u00e1s\u00e1rl\u00f3i v\u00e9lem\u00e9ny<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Minden rendel\u00e9st fedez a <a href=\"https:\/\/medsbase.com\/hu\/medsbase-re-shipment-assurance-policy\/\"><strong>\u00dajrak\u00fcld\u00e9si Garancia<\/strong><\/a> \u2014 ha a csomagod nem \u00e9rkezik meg 20 munkanapon bel\u00fcl, \u00fajrak\u00fcldj\u00fck.<\/p>\n<p style=\"font-size:13px;color:#666;margin:4px 0 18px;\">Minden rendel\u00e9st fedez a <a href=\"https:\/\/medsbase.com\/hu\/medsbase-re-shipment-assurance-policy\/\" style=\"color:#2c7cb0;\">\u00dajrak\u00fcld\u00e9si Garancia<\/a>.<\/p>\n<h3>Mi\u00e9rt rendelj a MedsBase-r\u00f3l<\/h3>\n<p>L-Glutathione is sourced from a WHO-GMP certified manufacturer. Every order ships in discreet, unbranded packaging worldwide and is covered by our Reshipment Assurance Policy. Pay securely with credit card, SEPA bank transfer, or cryptocurrency. See our <a href=\"https:\/\/medsbase.com\/hu\/reviews\/\">1400+ hiteles\u00edtett v\u00e1s\u00e1rl\u00f3i v\u00e9lem\u00e9ny<\/a>.<\/p>\n<h2>What is L-Glutathione?<\/h2>\n<p>L-Glutathione (reduced glutathione, GSH) is a tripeptide of glutamate, cysteine, and glycine. It is the major intracellular antioxidant, the substrate of glutathione peroxidase (the cellular hydrogen peroxide neutraliser), and a key thiol involved in detoxification of electrophiles, xenobiotics, and reactive oxygen species. Cellular GSH depletion is a feature of paracetamol toxicity, severe sepsis, oxidative liver injury, and chemotherapy-induced tissue damage.<\/p>\n<h2>Indik\u00e1ci\u00f3k<\/h2>\n<ul>\n<li><strong>Cisplatin \/ oxaliplatin chemotherapy-induced peripheral neuropathy<\/strong> &mdash; modest evidence for IV glutathione reducing severity<\/li>\n<li><strong>Non-alcoholic fatty liver disease (NAFLD)<\/strong> &mdash; reduces oxidative liver stress; evidence is modest<\/li>\n<li><strong>Hepatic detoxification support<\/strong> in alcohol-related liver disease (adjunct only)<\/li>\n<li><strong>Adjunctive antioxidant in chronic oxidative-stress conditions<\/strong><\/li>\n<li><strong>Idiopathic Parkinson&#8217;s disease<\/strong> &mdash; small studies show transient symptomatic benefit; not standard care<\/li>\n<li><strong>Autism spectrum disorder<\/strong> &mdash; research-only, no evidence base for clinical use<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>NOT a skin-whitening or anti-ageing drug<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Glutathione has been heavily marketed as an IV &#8220;skin-whitening&#8221; injection in cosmetic clinics across South-East Asia and Latin America. The FDA, EMA, and Indian CDSCO have all issued safety warnings against this off-label cosmetic use. Reported adverse effects include Stevens-Johnson syndrome, toxic epidermal necrolysis, kidney failure, severe abdominal pain, and at least one death. Skin colour is genetically determined and cosmetic glutathione carries serious risk for no proven benefit. We do not endorse this use.<\/p>\n<\/div>\n<h2>Oral vs IV<\/h2>\n<p>Oral glutathione has long been thought poorly absorbed (digested to amino acids in the gut). Recent studies suggest some intact GSH does reach systemic circulation and modestly increases tissue GSH levels at sustained doses. IV glutathione delivers higher levels but is hospital-only. For chemotherapy-induced neuropathy, IV is the route in most trials. For NAFLD and general antioxidant support, oral is reasonable.<\/p>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;\">\n<thead>\n<tr>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px;text-align:left;\">Agoprex is a 25 mg agomelatine tablet supplied by Sun Pharma. Agomelatine is mechanistically unique among antidepressants: it acts as an agonist at melatonin MT1 and MT2 receptors and an antagonist at 5-HT2C serotonin receptors. The dual mechanism resynchronises disrupted circadian rhythms (a feature of major depression) while indirectly increasing dopamine and noradrenaline release in the frontal cortex.<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px;text-align:left;\">Dose<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px;text-align:left;\">Megjegyz\u00e9sek<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Chemotherapy-induced peripheral neuropathy (cisplatin\/oxaliplatin)<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">1500&ndash;2500 mg IV before chemotherapy<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Specialist hospital setting; oncology decision<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">NAFLD<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">300&ndash;600 mg\/day oral<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Months; combine with weight loss and dietary change<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Hepatic adjunctive support<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">300 mg\/day oral<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Adjunct only; treat underlying cause<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Parkinson&#8217;s disease (research)<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">600 mg IV BID<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Research setting only; not standard care<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Mell\u00e9khat\u00e1sok<\/h2>\n<ul>\n<li><strong>Enyhe em\u00e9szt\u0151rendszeri panasz<\/strong> &mdash; nausea, dyspepsia (oral)<\/li>\n<li><strong>Sulphurous odour<\/strong> in urine or breath (cysteine content)<\/li>\n<li><strong>Severe cutaneous reactions<\/strong> (Stevens-Johnson syndrome, toxic epidermal necrolysis) &mdash; reported with IV cosmetic use, rare but life-threatening<\/li>\n<li><strong>Allergi\u00e1s reakci\u00f3<\/strong><\/li>\n<li><strong>Kidney injury<\/strong> &mdash; reported with high-dose cosmetic IV<\/li>\n<\/ul>\n<h2>Gy\u00f3gyszerk\u00f6lcs\u00f6nhat\u00e1sok<\/h2>\n<ul>\n<li><strong>Chemotherapy<\/strong> &mdash; theoretical concern of antioxidant interference with oxidative anti-cancer effect; oncology decision<\/li>\n<li><strong>Paracetamol<\/strong> &mdash; in paracetamol overdose, N-acetylcysteine (NAC, the precursor to GSH) is the antidote; oral or IV glutathione is not the standard of care for overdose (use NAC)<\/li>\n<li><strong>Cisplatin<\/strong> &mdash; intentional combination for neuroprotection<\/li>\n<\/ul>\n<h2>Ellenjavallatok<\/h2>\n<ul>\n<li>T\u00falerz\u00e9kenys\u00e9g<\/li>\n<li>Active malignancy without oncology approval (theoretical antioxidant interference)<\/li>\n<li>Severe renal impairment (caution with IV; cumulative cysteine load)<\/li>\n<\/ul>\n<h2>T\u00e1rol\u00e1s<\/h2>\n<p>Store below 25&deg;C in original packaging, protect from moisture and light.<\/p>\n<h2 id=\"faqs\">Gyakran Ism\u00e9telt K\u00e9rd\u00e9sek<\/h2>\n<h3>What does glutathione actually do?<\/h3>\n<p>It is the major intracellular antioxidant. The body makes it from glutamate, cysteine, and glycine. It neutralises reactive oxygen species, detoxifies xenobiotics in the liver via conjugation, and recycles other antioxidants (vitamin E, vitamin C). Cellular depletion is bad &mdash; central to paracetamol toxicity and severe sepsis. Whether supplementation in the well person provides benefit is the central question.<\/p>\n<h3>Will it whiten my skin?<\/h3>\n<p>No proven benefit for skin lightening, despite aggressive marketing. The FDA, EMA, and Indian CDSCO have issued safety warnings against this use. Reported severe adverse effects include Stevens-Johnson syndrome, toxic epidermal necrolysis, kidney failure, and death. Do not use glutathione for cosmetic purposes.<\/p>\n<h3>Will it help my liver?<\/h3>\n<p>Modest evidence in NAFLD &mdash; oral 300&ndash;600 mg\/day for months, combined with weight loss and dietary change, may modestly reduce liver enzymes. Not a substitute for managing the underlying cause (obesity, diabetes, alcohol).<\/p>\n<h3>Will it help chemotherapy side effects?<\/h3>\n<p>IV glutathione before cisplatin or oxaliplatin chemotherapy has modest evidence for reducing severity of peripheral neuropathy. This is an oncology setting decision &mdash; do not self-administer.<\/p>\n<h3>Is oral or IV better?<\/h3>\n<p>IV delivers more drug. Oral was long thought useless but recent evidence suggests modest tissue GSH increase at sustained doses. For most non-oncology indications, oral is the practical choice. For chemotherapy-induced neuropathy, IV is the route in trials.<\/p>\n<h3>Can I take it during chemotherapy?<\/h3>\n<p>Disclose to your oncologist. The neuroprotection-versus-tumour-protection balance is debated; specific protocols use specific timing of glutathione relative to chemotherapy infusion. Do not start without oncology sign-off.<\/p>\n<h3>Biztons\u00e1gos terhess\u00e9g alatt?<\/h3>\n<p>Limited data &mdash; avoid in pregnancy unless a specific indication requires it.<\/p>\n<h3>Will it improve my immunity?<\/h3>\n<p>Glutathione is essential for normal immune function and depletion is associated with various immune problems. Whether supplementation in well people improves immune function is unproven. Diet and lifestyle have larger effects.<\/p>\n<h3>What about oral N-acetylcysteine (NAC)?<\/h3>\n<p>NAC is the cysteine precursor that the body uses to synthesise glutathione. Oral NAC may be a better strategy for raising intracellular GSH than oral glutathione because of better gut absorption and direct cellular substrate use. NAC has stronger evidence for COPD exacerbation reduction and other indications.<\/p>\n<h3>Meddig kell szednem?<\/h3>\n<p>For the few evidence-based indications (NAFLD adjunct, chemotherapy neuroprotection in selected oncology settings, Parkinson&#8217;s research), continue for the duration the evidence supports. For &#8220;general antioxidant support&#8221; or &#8220;detox&#8221; use, evidence is too thin to recommend long-term use.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Egy\u00e9b vitaminok \u00e9s \u00e1sv\u00e1nyi anyagok<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/hu\/celin\/\">Celin<\/a> &mdash; vitamin C 500 mg<\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/c-vitan-z\/\">C Vitan Z<\/a> &mdash; vitamin C + zinc + minerals<\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/multivite-gold\/\">Multivite Gold<\/a> &mdash; comprehensive multivitamin softgel<\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/e-vitan-hair-oil\/\">E-Vitan Hajolaj<\/a> &mdash; topical vitamin E hair oil<\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/becozinc\/\">Becozinc<\/a> \u2014 B-komplex cinkkel<\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/metabolis\/\">Metabolis<\/a> &mdash; methylation-support multivitamin<\/li>\n<\/ul>\n<h2>Orvosi felel\u0151ss\u00e9gi nyilatkozat<\/h2>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;font-size:14px;color:#444;\">\nEz az oldal kiz\u00e1r\u00f3lag oktat\u00e1si c\u00e9lokat szolg\u00e1l, \u00e9s nem helyettes\u00edti a szakorvosi tan\u00e1csad\u00e1st. A vitamin- \u00e9s \u00e1sv\u00e1nyi anyag-p\u00f3tl\u00e1s ide\u00e1lis esetben laborat\u00f3riumi vizsg\u00e1latok alapj\u00e1n t\u00f6rt\u00e9njen, ha hi\u00e1ny gyan\u00faja mer\u00fcl fel. A nagyd\u00f3zis\u00fa p\u00f3tl\u00e1s nem \u00e1rtalmatlan \u2013 az A-vitamin teratog\u00e9n, az E-vitamin n\u00f6veli a v\u00e9rz\u00e9s kock\u00e1zat\u00e1t, a b\u00e9ta-karotin n\u00f6veli a t\u00fcd\u0151r\u00e1k kock\u00e1zat\u00e1t doh\u00e1nyosokn\u00e1l, a magas d\u00f3zis\u00fa kalciumnak pedig sz\u00edv- \u00e9s \u00e9rrendszeri hat\u00e1sai lehetnek. Terhes vagy szoptat\u00f3 betegek k\u00f6vess\u00e9k a sz\u00fcl\u00e9sz-n\u0151gy\u00f3gy\u00e1szati ir\u00e1nyelveket a terhess\u00e9g alatti vitaminp\u00f3tl\u00e1ssal kapcsolatban. A varfarin szed\u0151 betegeknek stabil K-vitamin-bevitelt kell tartaniuk. A levotiroxin, fluorkinolon vagy tetraciklin szed\u0151 betegeknek legal\u00e1bb 4 \u00f3r\u00e1val el kell k\u00fcl\u00f6n\u00edteni\u00fck a vas- \u00e9s kalciumbevitelt. Mindig jelentsen be minden t\u00e1pl\u00e1l\u00e9k-kieg\u00e9sz\u00edt\u0151t a fel\u00edr\u00f3 orvos\u00e1nak \u00e9s gy\u00f3gyszer\u00e9sz\u00e9nek.\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u2705 Antioxidant properties<br \/>\n\u2705 Skin lightening effects<br \/>\n\u2705 Detoxifies the body<br \/>\n\u2705 Supports immune function<br \/>\n\u2705 Contains L-Glutathione<\/p>\n<p>L-Glutathione contains L-Glutathione.<\/p>","protected":false},"featured_media":58200,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3863],"product_tag":[5738,3667,5737,4442,5739,5736,5740,4665],"class_list":{"0":"post-58199","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-vitamins-and-minerals","9":"product_tag-antioxidant-supplement","10":"product_tag-glutathione","11":"product_tag-gsh","12":"product_tag-l-glutathione","13":"product_tag-liver-support","14":"product_tag-reduced-glutathione","15":"product_tag-supplements","16":"product_tag-vitamins","18":"first","19":"instock","20":"shipping-taxable","21":"purchasable","22":"product-type-variable","23":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product\/58199","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/comments?post=58199"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/media\/58200"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/media?parent=58199"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product_brand?post=58199"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product_cat?post=58199"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product_tag?post=58199"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}