{"id":58609,"date":"2024-02-28T05:19:38","date_gmt":"2024-02-28T05:19:38","guid":{"rendered":"https:\/\/medsname.com\/oliza\/"},"modified":"2026-04-30T10:24:11","modified_gmt":"2026-04-30T10:24:11","slug":"oliza","status":"publish","type":"product","link":"https:\/\/medsbase.com\/hu\/product\/oliza\/","title":{"rendered":"Oliza"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div class=\"medsbase-tldr-answer\" style=\"background:#fff8d6;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">\u26a1 Gyors v\u00e1lasz<\/h3>\n<p style=\"margin-bottom:0;\">Oliza (Olanzapine 2.5 \/ 5 \/ 10 mg) is an atypical antipsychotic for schizophrenia, bipolar mania and maintenance, treatment-resistant depression (with fluoxetine), and acute agitation. The most robust antipsychotic effect of the atypicals \u2014 but the heaviest metabolic burden.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Mit kapsz a MedsBase-n\u00e1l:<\/strong> WHO-GMP min\u0151s\u00edt\u00e9s\u0171 gy\u00e1rt\u00f3 \u00b7 Diszkr\u00e9t csomagol\u00e1s \u00b7 Vil\u00e1gszerte sz\u00e1ll\u00edt\u00e1s \u00b7 1.400+ hiteles\u00edtett <a href=\"https:\/\/medsbase.com\/hu\/reviews\/\">v\u00e1s\u00e1rl\u00f3i v\u00e9lem\u00e9ny<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Minden rendel\u00e9st fedez a <a href=\"https:\/\/medsbase.com\/hu\/medsbase-re-shipment-assurance-policy\/\"><strong>\u00dajrak\u00fcld\u00e9si Garancia<\/strong><\/a> \u2014 ha a csomagod nem \u00e9rkezik meg 20 munkanapon bel\u00fcl, \u00fajrak\u00fcldj\u00fck.<\/p>\n<h3>Mi\u00e9rt rendelj a MedsBase-r\u00f3l<\/h3>\n<p>Oliza at MedsBase is supplied directly from a WHO-GMP certified manufacturer in plain, discreet packaging. Every order is covered by our <a href=\"https:\/\/medsbase.com\/hu\/medsbase-re-shipment-assurance-policy\/\">\u00dajrak\u00fcld\u00e9si Garancia<\/a> \u2014 20 \u00fczleti napos \u00e9rkez\u00e9si ablak vagy ingyenes \u00fajrasz\u00e1ll\u00edt\u00e1s \u2014 \u00e9s jogosult a mi <a href=\"https:\/\/medsbase.com\/hu\/loyalty-points\/\">h\u0171s\u00e9gprogramunkra<\/a>. .<\/p>\n<h2>What Oliza is and how it works<\/h2>\n<p>Oliza is an olanzapine tablet supplied by Cipla. Available strengths: <strong>2.5 \/ 5 \/ 10 mg<\/strong>. Olanzapine is a thienobenzodiazepine atypical antipsychotic with strong D2 antagonism, strong 5-HT2A antagonism, and substantial H1 (sedation, weight gain), M1 (anticholinergic), and \u03b11 (orthostasis) blockade. The H1+M1 receptor profile is responsible both for its calming\/sedative effect (useful in acute agitation) and for its metabolic burden.<\/p>\n<h2>What Agoprex is and how it works<\/h2>\n<table>\n<thead>\n<tr>\n<th>Agoprex is a 25 mg agomelatine tablet supplied by Sun Pharma. Agomelatine is mechanistically unique among antidepressants: it acts as an agonist at melatonin MT1 and MT2 receptors and an antagonist at 5-HT2C serotonin receptors. The dual mechanism resynchronises disrupted circadian rhythms (a feature of major depression) while indirectly increasing dopamine and noradrenaline release in the frontal cortex.<\/th>\n<th>Agomelatine has no SERT activity, no anticholinergic effects, and no histaminergic effects \u2014 explaining its very different side-effect profile from SSRIs and TCAs.<\/th>\n<th>Indications and dosing<\/th>\n<th>Indication<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Skizofr\u00e9nia (feln\u0151tt)<\/td>\n<td>5\u201310 mg OD<\/td>\n<td>10\u201320 mg OD<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>Skizofr\u00e9nia (serd\u00fcl\u0151 \u2265 13 \u00e9ves)<\/td>\n<td>2.5\u20135 mg OD<\/td>\n<td>10 mg\/nap<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>Bipol\u00e1ris m\u00e1ni\u00e1s epiz\u00f3d (feln\u0151tt)<\/td>\n<td>10\u201315 mg\/nap<\/td>\n<td>10\u201320 mg OD<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>Acute agitation (IM)<\/td>\n<td>10 mg IM<\/td>\n<td>\u2014<\/td>\n<td>3 doses\/24h<\/td>\n<\/tr>\n<tr>\n<td>Treatment-resistant depression (with fluoxetine)<\/td>\n<td>5 mg + 20 mg fluoxetine<\/td>\n<td>5\u201318 mg<\/td>\n<td>18 mg<\/td>\n<\/tr>\n<tr>\n<td>Older adults<\/td>\n<td>2.5\u20135 mg OD<\/td>\n<td>5\u201310 mg OD<\/td>\n<td>tolerancia alapj\u00e1n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Fontos biztons\u00e1gi megfontol\u00e1sok<\/h2>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>FDA fekete doboz \u2014 demenci\u00e1val \u00f6sszef\u00fcgg\u0151 pszich\u00f3zis<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Az \u00f6sszes at\u00edpusos antipszichotikum hordoz egy FDA fekete doboz figyelmeztet\u00e9st a megn\u00f6vekedett hal\u00e1loz\u00e1si kock\u00e1zat miatt (f\u0151leg cardiovascularis \u00e9s fert\u0151z\u00e9ses okokb\u00f3l), amikor id\u0151s, demenci\u00e1ban szenved\u0151 betegek viselked\u00e9szavarainak kezel\u00e9s\u00e9re haszn\u00e1lj\u00e1k. <strong>Az at\u00edpusos antipszichotikumok nincsenek j\u00f3v\u00e1hagyva demenci\u00e1val \u00f6sszef\u00fcgg\u0151 pszich\u00f3zis vagy agit\u00e1ci\u00f3 kezel\u00e9s\u00e9re<\/strong>. Haszn\u00e1latuk ebben a popul\u00e1ci\u00f3ban off-label, utols\u00f3 lehet\u0151s\u00e9g, id\u0151korl\u00e1tozott, \u00e9s kifejezett kock\u00e1zat-haszon besz\u00e9lget\u00e9st ig\u00e9nyel.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Heaviest metabolic burden of the atypicals<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Olanzapine produces the most weight gain (typically 4\u201310 kg in the first 6 months, sometimes far more), the most insulin resistance, and the most lipid disturbance of any commonly-used antipsychotic. Patients can develop type 2 diabetes within months of initiation. <strong>Mandatory monitoring: weight at every visit; fasting glucose \/ HbA1c and fasting lipids at baseline, 12 weeks, then 6-monthly.<\/strong> Counsel about diet and exercise from initiation.<\/p>\n<\/div>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Sedation and anticholinergic burden<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Strong sedation in the first 1\u20132 weeks. Anticholinergic effects (dry mouth, constipation, urinary hesitancy) are universal. Both lessen but do not disappear.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Olanzapine + benzodiazepine IM \u2014 caution<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Combining IM olanzapine with parenteral benzodiazepines has produced cases of severe hypotension, respiratory depression, and death. If both are clinically necessary in acute agitation, separate by \u2265 1 hour and monitor closely.<\/p>\n<\/div>\n<h2>Gyakori mell\u00e9khat\u00e1sok<\/h2>\n<ul>\n<li><strong>Weight gain and metabolic syndrome<\/strong> \u2014 the dominant long-term concern.<\/li>\n<li><strong>Sedation<\/strong> \u2014 universal at initiation.<\/li>\n<li><strong>Orthostatic hypotension<\/strong> \u2014 common at initiation; titrate slowly in older adults.<\/li>\n<li><strong>Anticholinergic<\/strong> \u2014 dry mouth, constipation, urinary hesitancy.<\/li>\n<li><strong>Akathisia, EPS<\/strong> \u2014 less common than risperidone, more common than aripiprazole.<\/li>\n<li><strong>Prolaktin<\/strong> \u2014 modest rise; less than risperidone.<\/li>\n<li><strong>Hepatic<\/strong> \u2014 transient AST\/ALT rises common.<\/li>\n<\/ul>\n<h2>Gy\u00f3gyszerk\u00f6lcs\u00f6nhat\u00e1sok<\/h2>\n<ul>\n<li><strong>CYP1A2 g\u00e1tl\u00f3k<\/strong> (fluvoxamine, ciprofloxacin) \u2014 raise olanzapine levels markedly.<\/li>\n<li><strong>Doh\u00e1nyz\u00e1s<\/strong> \u2014 induces CYP1A2; smokers have lower levels and need higher doses; smoking cessation can produce toxicity.<\/li>\n<li><strong>Karbamazepin<\/strong> \u2014 strong CYP1A2 induction; raises olanzapine clearance.<\/li>\n<li><strong>KNS depressz\u00e1nsok<\/strong> \u2014 additive sedation.<\/li>\n<li><strong>Anticholinerg szerek<\/strong> \u2014 additive burden.<\/li>\n<\/ul>\n<h2>Terhess\u00e9g, szoptat\u00e1s, gyermekkori kor<\/h2>\n<p>Pregnancy: limited data; weigh against untreated illness; late-pregnancy exposure can produce neonatal EPS or withdrawal. Breastfeeding: passes into milk; usually requires alternative or close monitoring. Paediatric: licensed from 13 (schizophrenia, bipolar).<\/p>\n<h2>T\u00e1rol\u00e1s<\/h2>\n<p>15\u201330 \u00b0C k\u00f6z\u00f6tt t\u00e1roljuk eredeti csomagol\u00e1sban.<\/p>\n<h2 id=\"faqs\">Gyakran Ism\u00e9telt K\u00e9rd\u00e9sek<\/h2>\n<h3>Why does Oliza cause so much weight gain?<\/h3>\n<p>Olanzapine&rsquo;s combined H1 antihistamine, 5-HT2C antagonism, and other receptor effects produce strong appetite stimulation, slowed satiety, and shifted carbohydrate preference. Weight gain is dose-related but real even at low doses. Counselling about diet and exercise from week 1, plus regular weight monitoring, is mandatory.<\/p>\n<h3>How is Oliza different from risperidone or aripiprazole?<\/h3>\n<p>Olanzapine has the strongest acute antipsychotic effect and the fastest calming action \u2014 useful in acute agitation. The trade-off is the heaviest metabolic burden. Risperidone is more efficacious for some positive symptoms but raises prolactin substantially. Aripiprazole is metabolically cleanest but produces more akathisia.<\/p>\n<h3>Should I monitor my blood sugar on Oliza?<\/h3>\n<p>Yes \u2014 fasting glucose or HbA1c at baseline, 12 weeks, and then 6-monthly. Olanzapine can produce diabetes within months of initiation, sometimes presenting with diabetic ketoacidosis. Don&rsquo;t skip the monitoring.<\/p>\n<h3>Can Oliza be used long-term?<\/h3>\n<p>Yes \u2014 particularly for schizophrenia maintenance where olanzapine often outperforms other atypicals on relapse rate. The metabolic burden is the main reason long-term use requires careful weight, glucose, and lipid monitoring, plus active management of cardiometabolic risk.<\/p>\n<h3>How long until Oliza works?<\/h3>\n<p>Calming effect within 1\u20132 hours of the first oral dose. Antipsychotic effect builds over 1\u20132 weeks; full antipsychotic and mood-stabilising effect at 4\u20136 weeks.<\/p>\n<h3>What about driving on Oliza?<\/h3>\n<p>Avoid driving in the first 1\u20132 weeks of titration. Most patients on stable doses drive normally, but the sedation can be persistent at higher doses.<\/p>\n<h3>Is the orodispersible form different?<\/h3>\n<p>Yes \u2014 orodispersible (ODT) versions of olanzapine exist (Zyprexa Zydis, Olimelt) and dissolve on the tongue without water. Bioequivalent to standard tablets but useful in adherence-uncertain or dysphagia patients.<\/p>\n<h3>Can Oliza be combined with fluoxetine?<\/h3>\n<p>Yes \u2014 the olanzapine-fluoxetine combination (OFC, Symbyax) is FDA-approved for treatment-resistant depression and bipolar depression. The fluoxetine partly addresses olanzapine&rsquo;s lack of antidepressant effect; olanzapine adds a strong mood-stabilising component.<\/p>\n<h3>Why does smoking matter?<\/h3>\n<p>Smoking strongly induces CYP1A2, which is olanzapine&rsquo;s main metabolic enzyme. Smokers metabolise olanzapine faster and need higher doses; abrupt cessation of smoking (e.g. hospital admission) can produce olanzapine toxicity if the dose isn&rsquo;t adjusted. Tell the prescriber if smoking status changes.<\/p>\n<h3>Can Oliza be stopped abruptly?<\/h3>\n<p>Generally not \u2014 taper over 2\u20134 weeks. Abrupt cessation can produce cholinergic rebound (nausea, sweating, insomnia) and an antipsychotic relapse. Never stop without prescriber agreement.<\/p>\n<h2>Egy\u00e9b Pszich\u00e9s Eg\u00e9szs\u00e9g\u00fcgyi Gy\u00f3gyszerek<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/hu\/aripicon\/\">Aripicon (Aripiprazole \u2014 D2 r\u00e9szleges agonista)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/olanzap\/\">Olanzap (Olanzapin \u2014 er\u0151s antipszichotikum)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/risdone\/\">Risdone (Risperidon)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/seroquit\/\">Seroquit (Kvetiapin \u2014 bipol\u00e1ris depresszi\u00f3)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/atlura\/\">Atlura (Lurasidon \u2014 metabolikusan kedvez\u0151)<\/a><\/li>\n<\/ul>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;font-size:0.9em;\">\n<strong>Orvosi nyilatkozat.<\/strong> Ez az oldal t\u00e1j\u00e9koztat\u00f3 jelleg\u0171, \u00e9s nem helyettes\u00edti az egy\u00e9ni orvosi tan\u00e1csad\u00e1st. A pszich\u00e9s eg\u00e9szs\u00e9g\u00fcgyi gy\u00f3gyszeres kezel\u00e9st k\u00e9pzett szakorvosnak kell kezdem\u00e9nyeznie, monitoroznia \u00e9s m\u00f3dos\u00edtania. Ha \u00d6n vagy valaki, akit ismer, \u00f6ngyilkoss\u00e1gi v\u00e1ls\u00e1gban van, azonnal l\u00e9pjen kapcsolatba a helyi v\u00e9szhelyzeti szolg\u00e1latokkal, vagy h\u00edvja az orsz\u00e1g \u00f6ngyilkoss\u00e1g-megel\u0151z\u0151 seg\u00e9lyvonal\u00e1t (USA\/Kanada: 988; UK: Samaritans 116 123; nemzetk\u00f6zi lista: <a href=\"https:\/\/findahelpline.com\/\" rel=\"nofollow noopener\" target=\"_blank\">findahelpline.com<\/a>).\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Oliza (Olanzapine 2.5\/5\/10 mg) \u2014 thienobenzodiazepine atypical for schizophrenia and bipolar mania. strong acute calming effect for severe agitation.<\/p>","protected":false},"featured_media":58610,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3906],"product_tag":[4527,4529],"class_list":{"0":"post-58609","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-mental-health-and-psychiatric-medications","9":"product_tag-olanzapine","10":"product_tag-oliza","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product\/58609","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/comments?post=58609"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/media\/58610"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/media?parent=58609"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product_brand?post=58609"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product_cat?post=58609"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product_tag?post=58609"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}