{"id":58731,"date":"2024-02-28T05:25:22","date_gmt":"2024-02-28T05:25:22","guid":{"rendered":"https:\/\/medsname.com\/endace\/"},"modified":"2026-04-30T10:24:09","modified_gmt":"2026-04-30T10:24:09","slug":"endace","status":"publish","type":"product","link":"https:\/\/medsbase.com\/hu\/product\/endace\/","title":{"rendered":"Endace"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Endace?<\/h3>\n<p style=\"margin:0;\"><strong>Endace<\/strong> egy tabletta form\u00e1j\u00fa gy\u00f3gyszer a Cipla gy\u00e1rt\u00e1s\u00e1ban, mely <strong>megestrol acetate<\/strong> itt <strong>40 mg and 160 mg<\/strong> &mdash; a synthetic progestin used as <strong>appetite stimulant<\/strong> in cancer cachexia and HIV-related anorexia, and as palliative endocrine therapy in advanced hormone-receptor-positive breast cancer and endometrial cancer. Standard appetite-stimulant dose: <strong>400&ndash;800 mg\/day<\/strong> (typically 800 mg\/day in cancer cachexia). Onset of appetite improvement at 1&ndash;2 weeks; weight gain (mostly fat, not muscle) at 4&ndash;6 weeks. <strong>Increased venous thromboembolism risk<\/strong> &mdash; caution in immobilised cancer patients; consider DVT prophylaxis. Other warnings: adrenal suppression with prolonged use (mineralocorticoid effect), hyperglycaemia, fluid retention.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Mit kapsz a MedsBase-n\u00e1l:<\/strong> WHO-GMP min\u0151s\u00edt\u00e9s\u0171 gy\u00e1rt\u00f3 \u00b7 Diszkr\u00e9t csomagol\u00e1s \u00b7 Vil\u00e1gszerte sz\u00e1ll\u00edt\u00e1s \u00b7 1.400+ hiteles\u00edtett <a href=\"https:\/\/medsbase.com\/hu\/reviews\/\">v\u00e1s\u00e1rl\u00f3i v\u00e9lem\u00e9ny<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Minden rendel\u00e9st fedez a <a href=\"https:\/\/medsbase.com\/hu\/medsbase-re-shipment-assurance-policy\/\"><strong>\u00dajrak\u00fcld\u00e9si Garancia<\/strong><\/a> \u2014 ha a csomagod nem \u00e9rkezik meg 20 munkanapon bel\u00fcl, \u00fajrak\u00fcldj\u00fck.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;\"><strong>\u26a0 Szakorvosi fel\u00fcgyelet sz\u00fcks\u00e9ges.<\/strong> A r\u00e1kk\u00e9sz\u00edtm\u00e9nyeket csak kezel\u0151 onkol\u00f3gus \u00edrhatja fel meger\u0151s\u00edtett diagn\u00f3zis, kiindul\u00e1si st\u00e1diummeghat\u00e1roz\u00e1s \u00e9s meghat\u00e1rozott kezel\u00e9si terv mellett. Soha ne kezdjen el, ne szak\u00edtson meg, ne m\u00f3dos\u00edtson adagot, \u00e9s ne haszn\u00e1ljon r\u00e1kk\u00e9sz\u00edtm\u00e9nyt onkol\u00f3giai ell\u00e1t\u00e1si terven k\u00edv\u00fcl. A legt\u00f6bb r\u00e1kk\u00e9sz\u00edtm\u00e9ny rendszeres v\u00e9rvizsg\u00e1lati monitoroz\u00e1st ig\u00e9nyel (teljes v\u00e9rk\u00e9p, m\u00e1jfunkci\u00f3, vesefunkci\u00f3), abszol\u00fat kontraindik\u00e1lt terhess\u00e9g alatt, \u00e9s jelent\u0151s gy\u00f3gyszerk\u00f6lcs\u00f6nhat\u00e1sokkal rendelkezik.<\/div>\n<div style=\"background:#f4f8fb;border:1px solid #d6e4ec;padding:12px 18px;margin:14px 0;border-radius:4px;font-size:14px;color:#3a5160;text-align:center;\">\n<strong>\ud83d\udd12 Titkos\u00edtott fizet\u00e9s<\/strong> \u00b7 <strong>\ud83d\udcb3 Hiteles\u00edtett feldolgoz\u00f3<\/strong> \u00b7 <strong>\ud83d\ude9a Vil\u00e1gszerte sz\u00e1ll\u00edtunk<\/strong> \u00b7 <strong>\u2b50 4,9\/5 1400+ \u00fcgyf\u00e9lt\u0151l<\/strong>\n<\/div>\n<h2 class=\"wp-block-heading\">What Is Endace?<\/h2>\n<p>Endace is an oral tablet from Cipla containing <strong>megestrol acetate<\/strong> (40 mg and 160 mg). Megestrol is a synthetic progestin with potent appetite-stimulant effects. The dominant modern use is as supportive care for <strong>cancer cachexia<\/strong> &mdash; the involuntary weight loss that affects most patients with advanced cancer and significantly worsens quality of life and treatment tolerance. It also retains a niche role in palliative endocrine therapy for advanced hormone-receptor-positive breast and endometrial cancer.<\/p>\n<h2 class=\"wp-block-heading\">Felhaszn\u00e1l\u00e1s \u00e9s indik\u00e1ci\u00f3k<\/h2>\n<ul>\n<li><strong>Cancer cachexia<\/strong> &mdash; appetite stimulation and weight gain<\/li>\n<li><strong>HIV-related anorexia and weight loss<\/strong> (less commonly used in 2026 with modern ART)<\/li>\n<li><strong>Palliative endocrine therapy in advanced HR+ breast cancer<\/strong> &mdash; later-line after AI and tamoxifen<\/li>\n<li><strong>Advanced endometrial cancer<\/strong> palliation<\/li>\n<li><strong>Off-label alkalmaz\u00e1s:<\/strong> hot flushes in patients who cannot use HRT<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Adagol\u00e1s \u00e9s szed\u00e9s m\u00f3dja<\/h2>\n<ul>\n<li><strong>Cancer cachexia \/ HIV anorexia:<\/strong> 400&ndash;800 mg\/day (often 800 mg\/day) of suspension or tablet equivalent<\/li>\n<li><strong>Breast cancer palliation:<\/strong> 160 mg\/day in divided doses<\/li>\n<li><strong>Endometrial cancer palliation:<\/strong> 80&ndash;320 mg\/day in divided doses<\/li>\n<\/ul>\n<ol>\n<li>Take with food to improve absorption and reduce nausea.<\/li>\n<li>Once daily or in divided doses depending on indication.<\/li>\n<li><strong>K\u00f6telez\u0151 monitoroz\u00e1s:<\/strong> baseline weight, blood glucose (megestrol commonly raises glucose); BP; signs of DVT; symptoms of adrenal suppression. Periodic FBC.<\/li>\n<li>For cachexia, expect appetite improvement at 1&ndash;2 weeks and weight gain at 4&ndash;6 weeks. Most weight gain is fat (not muscle), and adding nutritional support and resistance exercise where possible amplifies benefit.<\/li>\n<li><strong>Ne szak\u00edtsa meg hirtelen<\/strong> after prolonged use &mdash; risk of adrenal crisis from progestin-mediated adrenal suppression. Taper under specialist guidance.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Mell\u00e9khat\u00e1sok<\/h2>\n<p><strong>Gyakori:<\/strong> weight gain (the desired effect in cachexia), increased appetite, fluid retention, hyperglycaemia, breakthrough vaginal bleeding, mood changes, insomnia, sweating, hot flushes (paradoxically, in some patients).<\/p>\n<p><strong>Fontos:<\/strong><\/p>\n<ul>\n<li><strong>Venous thromboembolism (DVT, PE)<\/strong> &mdash; consider prophylactic anticoagulation in immobilised cancer patients<\/li>\n<li>Adrenal suppression with prolonged high-dose use<\/li>\n<li>New-onset diabetes or worsening glycaemic control<\/li>\n<li>Hypertonia<\/li>\n<li>Cushingoid features at high doses<\/li>\n<li>Menstrual irregularities<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Figyelmeztet\u00e9sek<\/h2>\n<ul>\n<li><strong>Terhess\u00e9g:<\/strong> contraindicated. Reliable contraception throughout treatment.<\/li>\n<li><strong>Szoptat\u00e1s:<\/strong> Ker\u00fclend\u0151.<\/li>\n<li><strong>Active VTE or recent thrombosis:<\/strong> avoid; alternatives include corticosteroids for cachexia (short-term) or omega-3.<\/li>\n<li><strong>Diabetes:<\/strong> monitor glucose carefully; insulin or hypoglycaemic dose adjustment likely.<\/li>\n<li><strong>Adrenal insufficiency:<\/strong> taper, do not stop abruptly after prolonged use.<\/li>\n<li><strong>Cardiovascular risk factors:<\/strong> caution &mdash; fluid retention, hypertension.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Gy\u00f3gyszerk\u00f6lcs\u00f6nhat\u00e1sok<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;\">Kombin\u00e1lhat\u00f3<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Hat\u00e1s<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Teend\u0151k<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Insulin or oral hypoglycaemics<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Megestrol raises blood glucose &mdash; reduced control<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor glucose; adjust diabetic medication.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Varfarin<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Possible INR change<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor INR.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Other progestins, oestrogens<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Stacked progestin \/ VTE effects<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Ker\u00fclje a kombin\u00e1ci\u00f3t.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Aromat\u00e1z-g\u00e1tl\u00f3k<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Megestrol provides exogenous progestin &mdash; rarely used together; sequence appropriately<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Specialist judgment.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">T\u00e1rol\u00e1s<\/h2>\n<ul>\n<li>Szobah\u0151m\u00e9rs\u00e9kleten, 15\u201325\u00b0C k\u00f6z\u00f6tt, eredeti blistercsomagol\u00e1sban.<\/li>\n<li>Out of reach of children and pets.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Kapcsol\u00f3d\u00f3 alternat\u00edv\u00e1k a MedsBase-en<\/h2>\n<p>Tov\u00e1bbi onkol\u00f3giai gy\u00f3gyszerek, amelyek e term\u00e9k mellett el\u00e9rhet\u0151k:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/hu\/endoxan\/\"><strong>Endoxan (ciklofoszfamid 50 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/celkeran\/\"><strong>Celkeran (chlorambucil 2 \/ 5 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/temotero\/\"><strong>Temotero (temozolomid 20 \/ 100 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/temozol-20\/\"><strong>Temozol (temozolomid 20 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/lomoother\/\"><strong>Lomoother (lomusztin 40 mg)<\/strong><\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/medsbase.com\/hu\/anti-cancer-medication\/\">\u00d6sszes r\u00e1kkel szembeni gy\u00f3gyszer b\u00f6ng\u00e9sz\u00e9se \u2192<\/a><\/p>\n<h2 id=\"faqs\">Gyakran Ism\u00e9telt K\u00e9rd\u00e9sek<\/h2>\n<h3 class=\"wp-block-heading\">When will I notice the appetite-stimulant effect?<\/h3>\n<p>Improved appetite typically starts at <strong>1\u20132 h\u00e9t<\/strong>. Measurable weight gain (mostly fat, with smaller fluid component) at <strong>4\u20136 h\u00e9t<\/strong>. Most weight gain is fat &mdash; megestrol does not significantly increase lean muscle mass. Adding nutritional support and gentle resistance exercise where possible amplifies the benefit.<\/p>\n<h3 class=\"wp-block-heading\">Why is venous thromboembolism a risk?<\/h3>\n<p>Megestrol is a progestin and shares the VTE risk of all hormonal contraceptives + progestins, particularly in cancer patients (who already carry a 5&ndash;10&times; increased baseline VTE risk). Be alert for unilateral leg swelling, sudden chest pain or breathlessness; seek same-day care if these occur. Consider prophylactic anticoagulation in immobilised cancer patients on megestrol.<\/p>\n<h3 class=\"wp-block-heading\">Will Endace raise my blood sugar?<\/h3>\n<p>Yes &mdash; commonly. Megestrol mimics some of the metabolic effects of corticosteroids (impairs insulin action, raises hepatic glucose output). Diabetic patients usually need their hypoglycaemic medication adjusted upward; new-onset diabetes can occur in non-diabetic patients on long-term high-dose megestrol. Monitor capillary glucose weekly initially.<\/p>\n<h3 class=\"wp-block-heading\">Why must I taper rather than stop Endace?<\/h3>\n<p>Long-term high-dose megestrol suppresses the adrenal axis (mineralocorticoid effect on the hypothalamic-pituitary-adrenal axis). Abrupt discontinuation after &gt; 4&ndash;6 weeks of high-dose use risks <strong>adrenal crisis<\/strong> &mdash; nausea, vomiting, hypotension, hypoglycaemia. Taper down over 2&ndash;4 weeks under specialist supervision.<\/p>\n<h3 class=\"wp-block-heading\">Are there alternatives to Endace for cancer cachexia?<\/h3>\n<p>Limited options with strong evidence. <strong>Kortikoszteroidok<\/strong> (dexamethasone 4 mg\/day) provide short-term appetite stimulation but have severe long-term toxicity. <strong>Cannabinoids<\/strong> (dronabinol where legal) have modest evidence. <strong>Anamorelin<\/strong> (ghrelin agonist) is approved in Japan and some other markets. <strong>Olanzapine<\/strong> low-dose has emerging supportive evidence. <strong>Nutritional and exercise interventions<\/strong> remain first-line. Discuss with the palliative care team.<\/p>\n<h3 class=\"wp-block-heading\">Can Endace treat my breast cancer?<\/h3>\n<p>Megestrol has a niche role in palliative endocrine therapy for HR+ advanced breast cancer &mdash; usually <strong>later-line after aromatase inhibitor and tamoxifen failure<\/strong>. It is no longer a first or second-line endocrine choice in most modern practice; CDK4\/6 inhibitors + AI \/ fulvestrant have largely replaced it. Specialist oncology decision.<\/p>\n<h3 class=\"wp-block-heading\">Is Endace safe in pregnancy?<\/h3>\n<p>No &mdash; contraindicated. Megestrol is a progestin and may cause fetal masculinisation and other developmental effects. Reliable contraception throughout treatment.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol on Endace?<\/h3>\n<p>Occasional small amounts are tolerable but heavy drinking compounds the metabolic side effects (hyperglycaemia, hypertension, fluid retention). Discuss with the supportive care team in the context of overall cancer care.<\/p>\n<p><!-- medsbase-why-order --><\/p>\n<h3>Mi\u00e9rt rendelj a MedsBase-r\u00f3l<\/h3>\n<p>Minden t\u00e9tel egy <strong>WHO-GMP tan\u00fas\u00edtott gy\u00e1rt\u00f3<\/strong>. WHO-GMP <a href=\"\/hu\/medsbase-re-shipment-assurance-policy\/\">\u00dajrak\u00fcld\u00e9si Garancia<\/a>: ha egy csomag nem \u00e9rkezik meg 20 munkanapon bel\u00fcl, ingyenes ut\u00e1nk\u00fcld\u00e9st biztos\u00edtunk, k\u00e9rd\u00e9sek n\u00e9lk\u00fcl.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Kapcsol\u00f3d\u00f3 r\u00e1kellenes gy\u00f3gyszerek<\/h3>\n<p>Tov\u00e1bbi onkol\u00f3giai gy\u00f3gyszerek, amelyek e term\u00e9k mellett el\u00e9rhet\u0151k:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/hu\/cytomid\/\">Cytomid (flutamide 250 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/bicalumutide\/\">Bicalumutide (bicalutamide 50 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/bdenza\/\">Bdenza (enzalutamide 40 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/tamilong\/\">Tamilong (tamoxifen 10\/20 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/xtane\/\">Xtane (exemeszt\u00e1n 25 mg)<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Manages appetite loss<br \/>\n\u2705 Treats breast cancer<br \/>\n\u2705 Ir\u00e1ny\u00edtja az endometriumr\u00e1kot<br \/>\n\u2705 Aids weight gain<br \/>\n\u2705 Jav\u00edtja az \u00e9letmin\u0151s\u00e9get<\/p>\n<p>Endace contains Megestrol Acetate.<\/p>","protected":false},"featured_media":58732,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[4556,4557],"class_list":{"0":"post-58731","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-endace","10":"product_tag-megestrol","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product\/58731","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/comments?post=58731"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/media\/58732"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/media?parent=58731"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product_brand?post=58731"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product_cat?post=58731"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product_tag?post=58731"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}