{"id":59500,"date":"2024-02-28T06:00:42","date_gmt":"2024-02-28T06:00:42","guid":{"rendered":"https:\/\/medsname.com\/primox\/"},"modified":"2026-05-01T10:49:15","modified_gmt":"2026-05-01T10:49:15","slug":"primox","status":"publish","type":"product","link":"https:\/\/medsbase.com\/hu\/product\/primox\/","title":{"rendered":"Primox"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Primox?<\/h3>\n<p style=\"margin:0;\"><strong>Primox<\/strong> tartalmaz <strong>nortriptyline 25 mg<\/strong> WHO-GMP min\u0151s\u00edt\u00e9s\u0171 gy\u00e1rt\u00f3t\u00f3l \u2014 egy <strong>secondary-amine tricyclic antidepressant (TCA)<\/strong> &mdash; the active metabolite of amitriptyline and the best-tolerated tricyclic for chronic migraine and neuropathic pain; the usual step-across when amitriptyline side effects are too severe. Although FDA-approved only for depression, tricyclic antidepressants have <strong>\u00e9vtizedeknyi bizony\u00edt\u00e9kokkal al\u00e1t\u00e1masztott haszn\u00e1lat alacsonyabb d\u00f3zisokban migr\u00e9n megel\u0151z\u00e9s\u00e9re, kr\u00f3nikus fesz\u00fclts\u00e9gfejf\u00e1j\u00e1sra, neuropath\u00e1s f\u00e1jdalomra, fibromyalgi\u00e1ra \u00e9s f\u00e1jdalommal j\u00e1r\u00f3 kr\u00f3nikus \u00e1lmatlans\u00e1g eset\u00e9n<\/strong>. . <strong>migr\u00e9n megel\u0151z\u00e9s<\/strong>: kezd\u00e9s 10 mg \u00e9jszakai adagol\u00e1ssal, titr\u00e1l\u00e1s <strong>25-75 mg nightly (migraine-prevention range)<\/strong>. A nyugtat\u00e1s. <strong>jelent\u0151sen nyugtat\u00f3 hat\u00e1s\u00fa <strong>m\u00e9rs\u00e9kelt<\/strong> (less H<sub>1<\/sub> blockade than amitriptyline) &mdash; take at night but daytime hangover is less common<\/strong> \u2014 always dose at night. <strong>Az antikolinerg terhel\u00e9s <strong>m\u00e9rs\u00e9kelt<\/strong> &mdash; meaningfully less dry mouth, constipation, and cognitive effects than amitriptyline. This is the main reason to choose nortriptyline over amitriptyline.<\/strong> Ellenjavallt friss sz\u00edvinfarktus, kontroll\u00e1latlan sz\u00edvritmuszavar, QT-intervallum meghosszabbod\u00e1s, egyidej\u0171 MAO-g\u00e1tl\u00f3 szed\u00e9se, sz\u0171k sz\u00f6g\u0171 glauk\u00f3ma, s\u00falyos m\u00e1jk\u00e1rosod\u00e1s \u00e9s vizeletretenci\u00f3 \/ t\u00fcnetes BPH eset\u00e9n. Az 50 \u00e9v feletti betegekn\u00e9l a sz\u00edvbiztons\u00e1g a f\u0151 szempont \u2014 a kezel\u00e9s megkezd\u00e9se el\u0151tt alap-ECG felv\u00e9tele szok\u00e1sos elj\u00e1r\u00e1s.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Mit kapsz a MedsBase-n\u00e1l:<\/strong> WHO-GMP min\u0151s\u00edt\u00e9s\u0171 gy\u00e1rt\u00f3 \u00b7 Diszkr\u00e9t csomagol\u00e1s \u00b7 Vil\u00e1gszerte sz\u00e1ll\u00edt\u00e1s \u00b7 1.400+ hiteles\u00edtett <a href=\"https:\/\/medsbase.com\/hu\/reviews\/\">v\u00e1s\u00e1rl\u00f3i v\u00e9lem\u00e9ny<\/a>\n<\/div>\n<h2 class=\"wp-block-heading\">What Is Primox?<\/h2>\n<p>Primox is an oral tablet of <strong>nortriptyline 25 mg<\/strong> from a WHO-GMP certified manufacturer, supplied in 30-180 tablet packs. Introduced in the 1960s as <strong>Pamelor<\/strong> (US) \/ <strong>Allegron<\/strong> (UK). Pharmacologically the desmethylated metabolite of amitriptyline &mdash; the body already converts amitriptyline into nortriptyline <em>in vivo<\/em>, so using nortriptyline directly bypasses the tertiary-amine side-effect burden.<\/p>\n<p>Nortriptyline is a <strong>secondary-amine tricyclic antidepressant (TCA)<\/strong> &mdash; the active metabolite of amitriptyline &mdash; one of the classic drugs of modern psychopharmacology. In contemporary clinical practice, tricyclics have largely been displaced by SSRIs for first-line depression treatment, but they remain a cornerstone of neurology and pain medicine at doses well below the antidepressant range, particularly for migraine prevention, chronic tension-type headache, and neuropathic pain.<\/p>\n<h2 class=\"wp-block-heading\">How Nortriptyline Prevents Migraine<\/h2>\n<p>Szerotonin + noradrenalin visszav\u00e9tel g\u00e1tl\u00e1sa<\/p>\n<ul>\n<li><strong>\u2014 fokozza az agyt\u00f6rzsben l\u00e9v\u0151 lesz\u00e1ll\u00f3 f\u00e1jdalomg\u00e1tl\u00f3 utakat, cs\u00f6kkentve a trigeminovaszkul\u00e1ris jelz\u00e9st<\/strong> \u2014 enhances descending inhibitory pain pathways in the brainstem, reducing trigeminovascular signalling<\/li>\n<li><strong>A k\u00f6zponti \u00e9rz\u00e9kenys\u00e9g cs\u00f6kkent\u00e9se<\/strong> \u2014 cs\u00f6kkenti a gerincvel\u0151 \u00e9s az trigeminusmag er\u0151s\u00edt\u00e9s\u00e9t, amely a kr\u00f3nikus napi fejf\u00e1j\u00e1st okozza<\/li>\n<li><strong>NMDA-receptor antagonizmus<\/strong> (gyenge) \u2014 cs\u00f6kkenti az excitatorikus glutam\u00e1t \u00e1tvitelt<\/li>\n<li><strong>N\u00e1triumcsatorna-blokkol\u00e1s<\/strong> \u2014 membr\u00e1nstabiliz\u00e1l\u00f3 hat\u00e1s a hiperexcit\u00e1bilis neuronokon<\/li>\n<li><strong>H<sub>1<\/sub> hisztamin blok\u00e1d<\/strong> \u2014 megmagyar\u00e1zza a nyugtat\u00f3 hat\u00e1st, amely k\u00f6zvetve seg\u00edti a migr\u00e9nt az\u00e1ltal, hogy jav\u00edtja az alv\u00e1smin\u0151s\u00e9get (a megzavart alv\u00e1s gyakori migr\u00e9nkiv\u00e1lt\u00f3)<\/li>\n<li><strong>Anticholinerg hat\u00e1s<\/strong> \u2014 sz\u00e1r\u00edtja a k\u00f6nnyeket\/ny\u00e1kot, nem hasznos migr\u00e9nre; megmagyar\u00e1zza a sz\u00e1jsz\u00e1razs\u00e1g mell\u00e9khat\u00e1st<\/li>\n<\/ul>\n<p>The migraine-prevention dose (25-75 mg nightly (migraine-prevention range)) is substantially lower than the antidepressant dose (75-100 mg nightly). This is important for three reasons: (1) lower doses minimise side effects, (2) the analgesic mechanism appears to be achieved at doses insufficient for antidepressant effect, and (3) it means Primox can be used for migraine prevention without necessarily being effective as an antidepressant. For patients with <strong>egy\u00fcttes migr\u00e9n \u00e9s depresszi\u00f3<\/strong>, van, a magasabb d\u00f3zisok egyszerre kezelik mindk\u00e9t \u00e1llapotot.<\/p>\n<h2 class=\"wp-block-heading\">J\u00f3v\u00e1hagyott \u00e9s bizony\u00edt\u00e9kokon alapul\u00f3 alkalmaz\u00e1sok<\/h2>\n<ul>\n<li><strong>Migr\u00e9n megel\u0151z\u00e9s<\/strong> \u2014 vil\u00e1gszerte off-label, de els\u0151 vonalbeli kezel\u00e9sk\u00e9nt elfogadott az Amerikai Fejf\u00e1j\u00e1s T\u00e1rsas\u00e1g, az Amerikai Neurol\u00f3giai Akad\u00e9mia \u00e9s az Eur\u00f3pai Fejf\u00e1j\u00e1s Sz\u00f6vets\u00e9g ir\u00e1nyelvei szerint. RCT bizony\u00edt\u00e9k a Couch 2011 \u00e9s a TOP-HAT vizsg\u00e1latb\u00f3l.<\/li>\n<li><strong>Chronic neuropathic pain<\/strong> &mdash; diabetic peripheral neuropathy, postherpetic neuralgia, post-stroke pain<\/li>\n<li><strong>Fibromyalgia<\/strong><\/li>\n<li><strong>Kr\u00f3nikus fesz\u00edt\u0151fejf\u00e1j\u00e1s<\/strong><\/li>\n<li><strong>Smoking cessation<\/strong> (one of the few non-nicotine, non-bupropion options with RCT evidence)<\/li>\n<li><strong>Depresszi\u00f3<\/strong> &mdash; original FDA indication; now typically reserved for treatment-resistant depression or when an SSRI has failed<\/li>\n<li><strong>Melancholic \/ severe depression<\/strong> in older patients<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Primox Dosage for Migraine Prevention<\/h2>\n<p>A triciklusos antidepressz\u00e1nsok <strong>nagyon alacsony kezd\u0151 adagokb\u00f3l t\u00f6rt\u00e9n\u0151 fokozatos n\u00f6vel\u00e9se<\/strong> az antikolinerg \u00e9s nyugtat\u00f3 mell\u00e9khat\u00e1sok minimaliz\u00e1l\u00e1sa \u00e9rdek\u00e9ben. A t\u00fcrelem elengedhetetlen \u2014 a ter\u00e1pi\u00e1s hat\u00e1s el\u00e9r\u00e9se \u00e1ltal\u00e1ban 8-12 h\u00e9tig tart.<\/p>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">L\u00e9p\u00e9s<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Adag (este bev\u00e9ve)<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Id\u0151tartam ezen a szinten<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">1-2. h\u00e9t<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">10 mg este<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Tolerancia ellen\u0151rz\u00e9se<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">3-4. h\u00e9t<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">25 mg este<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Adagn\u00f6vel\u00e9si l\u00e9p\u00e9s<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">5-8. h\u00e9t<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">50 mg (ha j\u00f3l toler\u00e1lj\u00e1k \u00e9s r\u00e9szleges v\u00e1lasz \u00e9rhet\u0151 el)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Leggyakoribb c\u00e9ladag<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">9-12. h\u00e9t<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">75 mg (ha m\u00e9g mindig nem teljes a v\u00e1lasz)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Fels\u0151 migr\u00e9nmegel\u0151z\u0151 adag<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Maxim\u00e1lis<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>100 mg nightly<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Ritk\u00e1n sz\u00fcks\u00e9ges; ha sz\u00fcks\u00e9ges, fontolja meg alternat\u00edv szer haszn\u00e1lat\u00e1t<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>\u00c9rt\u00e9kelje a hat\u00e1st 8-12 h\u00e9t ut\u00e1n.<\/strong> Vezessen migr\u00e9nnapl\u00f3t a kezel\u00e9s megkezd\u00e9se el\u0151tt \u00e9s a 12. h\u00e9ten. Klinikailag jelent\u0151s v\u00e1lasznak sz\u00e1m\u00edt a havi migr\u00e9nes napok \u226550%-os cs\u00f6kken\u00e9se. Ha 12 h\u00e9t ut\u00e1n a c\u00e9ladagn\u00e1l nincs v\u00e1lasz, v\u00e1ltson megel\u0151z\u0151 kezel\u00e9sre.<\/p>\n<p><strong>Adagol\u00e1s egy\u00e9b indik\u00e1ci\u00f3kra:<\/strong><\/p>\n<ul>\n<li>Neuropathic pain: 10-50 mg nightly<\/li>\n<li>Depression: 75-100 mg nightly<\/li>\n<\/ul>\n<p><strong>Adagol\u00e1s:<\/strong> eg\u00e9szben nyelje le v\u00edzzel. \u00c9jszak\u00e1nk\u00e9nt szedje \u2014 <strong>m\u00e9rs\u00e9kelt<\/strong> (less H<sub>1<\/sub> blockade than amitriptyline) &mdash; take at night but daytime hangover is less common Take consistently at the same time each night for steady plasma levels.<\/p>\n<p><strong>Megsz\u00fcntet\u00e9s:<\/strong> fokozatosan sz\u00fcntesse meg 2-4 h\u00e9t alatt (5-7 naponta 10-25 mg-mal cs\u00f6kkentve). A triciklusos szer hirtelen abbahagy\u00e1sa t\u00f6bb heti haszn\u00e1lat ut\u00e1n <strong>megszak\u00edt\u00e1si szindr\u00f3m\u00e1t<\/strong> okozhat \u2014 rossz k\u00f6z\u00e9rzet, hidegr\u00e1z\u00e1s, izzad\u00e1s, alv\u00e1szavar, GI panaszok, \u00e9l\u00e9nk \u00e1lmok. 1-2 h\u00e9t alatt elm\u00falik, de kellemetlen. Soha ne hagyja abba hirtelen.<\/p>\n<h2 class=\"wp-block-heading\">Alapvizsg\u00e1latok \u00e9s monitoroz\u00e1s<\/h2>\n<p>Before starting Primox:<\/p>\n<ul>\n<li><strong>Alapvonalas EKG<\/strong> \u2014 k\u00fcl\u00f6n\u00f6sen 50 \u00e9v felett, sz\u00edv- \u00e9s \u00e9rrendszeri el\u0151zm\u00e9nyekkel rendelkez\u0151 betegekn\u00e9l, valamint QT-intervallumot meghosszabb\u00edt\u00f3 gy\u00f3gyszereket szed\u0151kn\u00e9l. A triciklusos antidepressz\u00e1nsok meghosszabb\u00edtj\u00e1k a QT-intervallumot \u00e9s kamrai aritmi\u00e1kat v\u00e1lthatnak ki fog\u00e9kony egy\u00e9nekben. Ker\u00fclend\u0151, ha QTc &gt;450 ms.<\/li>\n<li><strong>Elektrolitok<\/strong> \u2014 a hipokal\u00e9mia \u00e9s hipomagn\u00e9zia fokozza a QT-meghosszabb\u00edt\u00e1s kock\u00e1zat\u00e1t. Korrig\u00e1ljuk el\u0151sz\u00f6r, ha abnorm\u00e1lis.<\/li>\n<li><strong>M\u00e1jfunkci\u00f3s tesztek<\/strong> \u2014 a triciklusos szerek m\u00e1jban metaboliz\u00e1l\u00f3dnak; enyhe m\u00e1jk\u00e1rosod\u00e1sn\u00e1l d\u00f3ziscs\u00f6kkent\u00e9s sz\u00fcks\u00e9ges, s\u00falyos esetben ker\u00fclend\u0151k.<\/li>\n<li><strong>Glaukoma sz\u0171r\u00e9s<\/strong> \u2014 a sz\u0171k sz\u00f6gl\u0171 glaukoma abszol\u00fat kontraindik\u00e1ci\u00f3 (az anticholinerg hat\u00e1s akut sz\u00f6gz\u00e1r\u00f3d\u00e1st v\u00e1lthat ki).<\/li>\n<li><strong>Vizeletvizsg\u00e1lat<\/strong> 50 \u00e9v feletti f\u00e9rfiakn\u00e1l \u2014 a t\u00fcnetes BPH \/ vizeletretenci\u00f3 rosszabbodhat anticholinerg hat\u00e1s miatt.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Mell\u00e9khat\u00e1sok<\/h2>\n<p><strong>Nagyon gyakori (&gt;10%):<\/strong><\/p>\n<ul>\n<li><strong>Nyugtat\u00e1s, \u00e1lmoss\u00e1g, reggeli m\u00e1snaposs\u00e1g<\/strong> \u2014 d\u00f3zisf\u00fcgg\u0151; r\u00e9szben alkalmazkodik 2-4 h\u00e9t alatt<\/li>\n<li><strong>Sz\u00e1j sz\u00e1razs\u00e1g, sz\u00e1raz szemek<\/strong> (anticholinerg)<\/li>\n<li><strong>Sz\u00e9kreked\u00e9s<\/strong> (anticholinerg) \u2014 n\u00f6velje a rost- \u00e9s v\u00edzbevitelt; sz\u00fcks\u00e9g eset\u00e9n adjon hozz\u00e1 hashajt\u00f3t<\/li>\n<li><strong>S\u00falygyarapod\u00e1s<\/strong> \u2014 \u00e1tlagosan 1-3 kg 6-12 h\u00f3nap alatt migr\u00e9n-megel\u0151z\u0151 d\u00f3zisokn\u00e1l; t\u00f6bb antidepressz\u00e1ns d\u00f3zisokn\u00e1l<\/li>\n<li><strong>Posztur\u00e1lis hypot\u00f3nia \u00e9s sz\u00e9d\u00fcl\u00e9s<\/strong> \u2014 kiemelked\u0151bb az id\u0151sekn\u00e9l; lassan keljen fel fekv\u0151\/\u00fcl\u0151 helyzetb\u0151l<\/li>\n<\/ul>\n<p><strong>Gyakori (1-10%):<\/strong><\/p>\n<ul>\n<li>Elhom\u00e1lyosult l\u00e1t\u00e1s (anticholinerg)<\/li>\n<li>Vizelet\u00fcr\u00edt\u00e9si neh\u00e9zs\u00e9g vagy retenci\u00f3 (k\u00fcl\u00f6n\u00f6sen BPH-s f\u00e9rfiakn\u00e1l)<\/li>\n<li>Sz\u00edvdobog\u00e1s\u00e9rz\u00e9s, tachycardia, enyhe QT-hosszabbod\u00e1s<\/li>\n<li>Mem\u00f3riazavarok, sz\u00f3keres\u00e9si neh\u00e9zs\u00e9gek (d\u00f3zisf\u00fcgg\u0151; reverzibilis)<\/li>\n<li>Tremor (finom; j\u00f3indulat\u00fa)<\/li>\n<li>\u00cdz\u00e9rz\u00e9kel\u00e9s v\u00e1ltoz\u00e1sa<\/li>\n<li>Szexu\u00e1lis diszfunkci\u00f3 (libid\u00f3cs\u00f6kken\u00e9s, mereved\u00e9si zavar, anorgazmia) \u2014 d\u00f3zisf\u00fcgg\u0151<\/li>\n<li>Izzad\u00e1s<\/li>\n<li>Fokozott \u00e9tv\u00e1gy<\/li>\n<\/ul>\n<p><strong>Nem gyakori, de fontos:<\/strong><\/p>\n<ul>\n<li><strong>QT-intervallum meghosszabbod\u00e1sa \/ kamrai aritmia<\/strong> \u2014 k\u00fcl\u00f6n\u00f6sen magasabb d\u00f3zisokn\u00e1l, t\u00faladagol\u00e1skor vagy m\u00e1s QT-intervallumot meghosszabb\u00edt\u00f3 gy\u00f3gyszerekkel kombin\u00e1lva. A triciklusos antidepressz\u00e1nsok t\u00faladagol\u00e1sa a <strong>legkardiotoxikusabb a gyakori antidepressz\u00e1ns-oszt\u00e1lyok t\u00faladagol\u00e1sai k\u00f6z\u00fcl<\/strong>; sz\u00e1nd\u00e9kos bevitel eset\u00e9n orvosi s\u00fcrg\u0151ss\u00e9gi beavatkoz\u00e1s sz\u00fcks\u00e9ges.<\/li>\n<li><strong>Akut sz\u00f6gz\u00e1r\u00f3 glauk\u00f3ma<\/strong> \u00e9rz\u00e9keny szemekben<\/li>\n<li><strong>Rohamok<\/strong> magasabb d\u00f3zisokn\u00e1l, k\u00fcl\u00f6n\u00f6sen alacsonyabb k\u00fcsz\u00f6b\u00e9rt\u00e9kkel rendelkez\u0151 betegekn\u00e9l<\/li>\n<li><strong>\u00d6ngyilkos gondolatok<\/strong> \u2014 oszt\u00e1lyszint\u0171 figyelmeztet\u00e9s minden antidepressz\u00e1nsra, k\u00fcl\u00f6n\u00f6sen az els\u0151 4 h\u00e9tben \u00e9s 25 \u00e9v alatti betegekn\u00e9l<\/li>\n<li><strong>Szerotonin szindr\u00f3ma<\/strong> \u2014 MAO-g\u00e1tl\u00f3kkal vagy m\u00e1s szerotonerg szerek kombin\u00e1l\u00e1sakor<\/li>\n<li><strong>Hyponatraemia<\/strong> (SIADH) \u2014 k\u00fcl\u00f6n\u00f6sen id\u0151s korban<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Ellenjavallatok<\/h2>\n<ul>\n<li>Friss myocardialis infarctus (az elm\u00falt 3 h\u00f3napban)<\/li>\n<li>Nem kontroll\u00e1lt sz\u00edvritmuszavar vagy sz\u00edvblokk<\/li>\n<li>Ismert velesz\u00fcletett hossz\u00fa QT-szindr\u00f3ma vagy QTc &gt;450 ms<\/li>\n<li>S\u00falyos m\u00e1jel\u00e9gtelens\u00e9g<\/li>\n<li>MAO-g\u00e1tl\u00f3 egyidej\u0171 haszn\u00e1lata vagy MAO-g\u00e1tl\u00f3 abbahagy\u00e1s\u00e1t k\u00f6vet\u0151 14 nap (fenelzin, tr\u00e1nilcipromin, moklobemid, szelegilin, linezolid)<\/li>\n<li>Sz\u0171ksz\u00f6g\u0171 glauk\u00f3ma<\/li>\n<li>Jelent\u0151s vizeletretenci\u00f3<\/li>\n<li>Akut porfiria<\/li>\n<li>Triciklusos antidepressz\u00e1nsokra \u00e9rz\u00e9kenys\u00e9g<\/li>\n<\/ul>\n<p><strong>Terhess\u00e9g:<\/strong> Nortriptyline is FDA Pregnancy Category C. Decades of observational data are broadly reassuring; no major congenital malformation signal. Neonatal withdrawal syndrome can occur with third-trimester use. For migraine prevention in pregnancy, <a href=\"https:\/\/medsbase.com\/hu\/inderal\/\">propranolol<\/a> az els\u0151 v\u00e1laszt\u00e1s; a triciklusos antidepressz\u00e1nsok \u00e9sszer\u0171 m\u00e1sodik lehet\u0151s\u00e9gnek sz\u00e1m\u00edtanak b\u00e9ta-blokkol\u00f3 sikertelens\u00e9ge eset\u00e9n.<\/p>\n<p><strong>Szoptat\u00e1s:<\/strong> Nortriptyline passes into breast milk in small amounts. Generally considered compatible during breastfeeding; infant exposure is low.<\/p>\n<p><strong>Id\u0151s (&gt;65 \u00e9ves):<\/strong> a triciklusok szerepelnek a <strong>Beers-list\u00e1n, mint potenci\u00e1lisan nem megfelel\u0151 gy\u00f3gyszerek id\u0151sebb feln\u0151ttek sz\u00e1m\u00e1ra<\/strong> because of anticholinergic burden (falls risk, cognitive effects, constipation, urinary retention). Nortriptyline is the <strong>preferred tricyclic for elderly patients<\/strong> when one is required &mdash; its lower anticholinergic and sedative profile makes it safer than amitriptyline.<\/p>\n<h2 class=\"wp-block-heading\">Gy\u00f3gyszerk\u00f6lcs\u00f6nhat\u00e1sok<\/h2>\n<ul>\n<li><strong>MAO-g\u00e1tl\u00f3k<\/strong> (fenelzin, tranylcipromin, moklobemid, szelegilin, linezolid) \u2014 kontraindik\u00e1lt; szerotonin szindr\u00f3ma kock\u00e1zata. Legal\u00e1bb 14 napos k\u00fcl\u00f6nbs\u00e9ggel alkalmazhat\u00f3.<\/li>\n<li><strong>SSRI-k \/ SNRI-k<\/strong> (fluoxetine, sertraline, paroxetine, citalopram, venlafaxine, duloxetine) &mdash; additive serotonergic effect; fluoxetine and paroxetine are strong CYP2D6 inhibitors and markedly raise tricyclic plasma levels (reduce Primox dose by 50%).<\/li>\n<li><strong>Egy\u00e9b QT-idej\u00e9t meghosszabb\u00edt\u00f3 gy\u00f3gyszerek<\/strong> (kinolon antibiotikumok, makrolidok, metadon, antipszichotikumok, ondansetron, domperidon) \u2014 addit\u00edv QT-hosszabbod\u00e1s; ker\u00fclend\u0151k vagy EKG monitoroz\u00e1s sz\u00fcks\u00e9ges<\/li>\n<li><strong>Anticholinerg szerek<\/strong> (antihisztaminok, antispazmodikumok, oxibutinin, szkopolamin) \u2014 addit\u00edv antikolinerg terhel\u00e9s; k\u00fcl\u00f6n\u00f6sen probl\u00e9m\u00e1s id\u0151sekn\u00e9l<\/li>\n<li><strong>Nyugtat\u00f3 gy\u00f3gyszerek<\/strong> (benzodiazepinek, opioidok, alkohol) \u2014 addit\u00edv CNS depresszi\u00f3<\/li>\n<li><strong>Adrenerg gy\u00f3gyszerek<\/strong> (k\u00f6zvetlen\u00fcl hat\u00f3 szimpatomimetikumok, stimul\u00e1nsok) \u2014 t\u00falzott v\u00e1lasz; ker\u00fclend\u0151 a fenilefrin tartalm\u00fa dekongeszt\u00e1nsok magasabb adagjain\u00e1l<\/li>\n<li><strong>Varfarin<\/strong> \u2014 a triciklusok n\u00f6velhetik a warfarin szintj\u00e9t; INR monitoroz\u00e1s sz\u00fcks\u00e9ges<\/li>\n<li><strong>Tramadol<\/strong> \u2014 additive seizure and serotonin-syndrome risk; avoid<\/li>\n<li><strong>Karbamazepin, fenitoin<\/strong> \u2014 reduce tricyclic levels via CYP induction<\/li>\n<li><strong>Alkohol<\/strong> \u2014 additive CNS depression and impaired driving; limit intake<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Amitriptyline vs Nortriptyline \u2014 Which Tricyclic?<\/h2>\n<p>Amitriptyline is metabolised <em>in vivo<\/em> into nortriptyline (its active metabolite). Both work for migraine prevention; they differ in side-effect emphasis:<\/p>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\"><\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Amitriptyline (<a href=\"https:\/\/medsbase.com\/hu\/cotrip\/\">Cotrip<\/a>)<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Nortriptyline (<a href=\"https:\/\/medsbase.com\/hu\/primox\/\">Primox<\/a>)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Chemical class<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Tertiary amine<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Secondary amine (active metabolite of amitriptyline)<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Sedation<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Strong (H<sub>1<\/sub> blockade)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">M\u00e9rs\u00e9kelt<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Antikolinerg terhel\u00e9s<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Er\u0151s<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">M\u00e9rs\u00e9kelt \u2014 kb. az amitriptilin fel\u00e9nek megfelel\u0151<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Posztur\u00e1lis hypot\u00f3nia<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Gyakori<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Kevesebb gyakoris\u00e1g\u00fa<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Migr\u00e9n hat\u00e9konys\u00e1g<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Referenciaszint\u0171<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Nagyj\u00e1b\u00f3l egyen\u00e9rt\u00e9k\u0171<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Legjobb v\u00e1laszt\u00e1s<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Migr\u00e9n + alv\u00e1szavar + f\u00e1jdalom \u2014 a szed\u00e1ci\u00f3 ter\u00e1pi\u00e1s hat\u00e1s\u00fa<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Migr\u00e9n olyan betegekn\u00e9l, ahol a szed\u00e1ci\u00f3 vagy az antikolinerg hat\u00e1sok korl\u00e1toz\u00f3ak; id\u0151s kor\u00faak<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Id\u0151s kor\u00faak sz\u00e1m\u00e1ra val\u00f3 alkalmass\u00e1g<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Nem aj\u00e1nlott (Beers-lista)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Az els\u0151 v\u00e1laszt\u00e1s triciklusos antidepressz\u00e1ns, ha sz\u00fcks\u00e9ges<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>If a full tertiary-amine tricyclic effect is needed (e.g. patient has marked insomnia as part of the migraine syndrome), <a href=\"https:\/\/medsbase.com\/hu\/cotrip\/\">amitriptyline (Cotrip)<\/a> is the alternative &mdash; more sedating and more analgesic, at the cost of higher anticholinergic burden.<\/p>\n<h2 class=\"wp-block-heading\">T\u00e1rol\u00e1s<\/h2>\n<p>25\u00b0C alatt t\u00e1roljuk az eredeti blistercsomagol\u00e1sban. F\u00e9nyt\u0151l v\u00e9dj\u00fck. Tartsuk gyermekek el\u0151l \u2013 <strong>a triciklusos antidepressz\u00e1ns t\u00faladagol\u00e1sa viszonylag kis d\u00f3zisban is hal\u00e1los lehet kisgyermekekn\u00e9l<\/strong>.<\/p>\n<h2 id=\"faqs\">Gyakran Ism\u00e9telt K\u00e9rd\u00e9sek<\/h2>\n<h3 class=\"wp-block-heading\">Will Primox work for my migraine if I&#8217;m not depressed?<\/h3>\n<p>Igen \u2013 a migr\u00e9nmegel\u0151z\u00e9s mechanizmusa (lesz\u00e1ll\u00f3 f\u00e1jdalom\u00fat-modul\u00e1ci\u00f3 + n\u00e1triumcsatorna-blokkol\u00e1s) j\u00f3val az antidepressz\u00e1ns tartom\u00e1ny alatti d\u00f3zisokon is hat\u00e1sos. A triciklusos antidepressz\u00e1nst szed\u0151k kb. 50%-a, akik nem depresszi\u00f3sak, m\u00e9gis jelent\u0151s migr\u00e9ncs\u00f6kken\u00e9st tapasztal. Sok beteg kezdetben vonakodik \u201cantidepressz\u00e1nst\u201d szedni migr\u00e9nre, de 10-50 mg esti adagban gyakorlatilag neuromodul\u00e1tork\u00e9nt hat, nem antidepressz\u00e1nsk\u00e9nt.<\/p>\n<h3 class=\"wp-block-heading\">How long before Primox starts preventing migraines?<\/h3>\n<p>Allow 8-12 weeks at target dose. Some patients see benefit earlier (at 4-6 weeks), but a fair trial is 12 weeks. Keep a migraine diary at baseline and at week 12. If no response at 100 mg nightly after 12 weeks, switch preventive.<\/p>\n<h3 class=\"wp-block-heading\">Mi\u00e9rt vagyok olyan \u00e1lmos m\u00e1snap reggel?<\/h3>\n<p>Nortriptyline has a long elimination half-life (12-36 hours for amitriptyline\/nortriptyline). The sedation peaks overnight but can persist into morning. Mitigate by: (1) taking the dose earlier in the evening (e.g. 8 pm rather than bedtime), (2) reducing the dose if sedation is disabling, (3) switching to a less-sedating preventive like <a href=\"https:\/\/medsbase.com\/hu\/inderal\/\">propranolol<\/a> vagy <a href=\"https:\/\/medsbase.com\/hu\/topicon\/\">topiram\u00e1t<\/a>. Morning hangover usually improves over 2-4 weeks as tolerance develops.<\/p>\n<h3 class=\"wp-block-heading\">Will Primox make me gain weight?<\/h3>\n<p>N\u00e9h\u00e1ny embern\u00e9l igen \u2013 \u00e1tlagosan 1-3 kg 6-12 h\u00f3nap alatt migr\u00e9nmegel\u0151z\u0151 d\u00f3zisokon. Mechanizmus: fokozott \u00e9tv\u00e1gy a H<sub>1<\/sub> \u00e9s 5-HT<sub>2C<\/sub> blok\u00e1d. Ha a s\u00falygyarapod\u00e1s aggodalomra ad okot, <a href=\"https:\/\/medsbase.com\/hu\/topicon\/\">topiram\u00e1t<\/a> s\u00falycs\u00f6kken\u00e9st okoz \u00e9s <a href=\"https:\/\/medsbase.com\/hu\/inderal\/\">propranolol<\/a> is weight-neutral. Alternatively, nortriptyline already has a better weight profile than amitriptyline.<\/p>\n<h3 class=\"wp-block-heading\">Is Primox safe if I have heart problems?<\/h3>\n<p>\u00d3vatoss\u00e1g. A triciklusok meghosszabb\u00edtj\u00e1k a QT-intervallumot \u00e9s kamrai aritmi\u00e1kat v\u00e1lthatnak ki \u00e9rz\u00e9keny egy\u00e9nekben. Abszol\u00fat ellenjavallatok: friss sz\u00edvinfarktus (3 h\u00f3napon bel\u00fcl), kontroll\u00e1latlan sz\u00edvritmuszavar, velesz\u00fcletett hossz\u00fa QT-szindr\u00f3ma, alapvonali EKG-n QTc &gt;450 ms. Relat\u00edv \u00f3vatoss\u00e1g: kor\u00e1bbi sz\u00edvkoszor\u00fa\u00e9r-betegs\u00e9g, szalagblokk, vagy egyidej\u0171 QT-intervallumot hosszabb\u00edt\u00f3 gy\u00f3gyszeres kezel\u00e9s. Alapvonali EKG k\u00e9sz\u00edt\u00e9se szok\u00e1sos gyakorlat 50 \u00e9v feletti betegekn\u00e9l a kezel\u00e9s megkezd\u00e9se el\u0151tt.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Primox with a triptan when a migraine attack strikes?<\/h3>\n<p>Yes &mdash; tricyclics are preventive, triptans are abortive. They work through different mechanisms. Take Primox nightly for prevention; take a triptan (<a href=\"https:\/\/medsbase.com\/hu\/sumitop\/\">sumatriptan<\/a>, <a href=\"https:\/\/medsbase.com\/hu\/maxtan\/\">rizatript\u00e1n<\/a>, <a href=\"https:\/\/medsbase.com\/hu\/zolitas-ods\/\">zolmitript\u00e1n<\/a>) sz\u00fcks\u00e9g szerint szedj\u00fck \u00e1tt\u00f6r\u00e9ses rohamok eset\u00e9n. Elm\u00e9leti szerotoninszindr\u00f3ma-kock\u00e1zat \u00e1ll fenn (2006-os FDA-figyelmeztet\u00e9s), de a val\u00f3s\u00e1gos adatok azt mutatj\u00e1k, hogy a kombin\u00e1ci\u00f3 j\u00f3l toler\u00e1lhat\u00f3 a klinikai gyakorlatban.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol on Primox?<\/h3>\n<p>Minimise alcohol intake. Tricyclics and alcohol are additive for sedation, cognitive impairment, and impaired driving. Alcohol is also a common migraine trigger, so reducing intake often improves migraine independent of Primox. Occasional small amounts (a glass of wine) are unlikely to cause problems; regular or heavy drinking is contraindicated.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Primox in pregnancy?<\/h3>\n<p>Nortriptyline has decades of observational pregnancy data with no major malformation signal (FDA Category C). For migraine prevention in pregnancy, <a href=\"https:\/\/medsbase.com\/hu\/inderal\/\">propranolol<\/a> els\u0151 v\u00e1laszt\u00e1s; a triciklusok \u00e9sszer\u0171 m\u00e1sodik lehet\u0151s\u00e9g, ha a propranolol ellenjavallt vagy hat\u00e1stalan. \u00dajsz\u00fcl\u00f6ttkori elvon\u00e1si t\u00fcnetek (ingerl\u00e9kenys\u00e9g, t\u00e1pl\u00e1l\u00e1si neh\u00e9zs\u00e9g) el\u0151fordulhatnak harmadik trimeszteri expoz\u00edci\u00f3 eset\u00e9n, de napokon bel\u00fcl rendez\u0151dnek.<\/p>\n<h3 class=\"wp-block-heading\">How do I stop Primox?<\/h3>\n<p>Fokozatosan cs\u00f6kkentve 2-4 h\u00e9t alatt (5-7 naponk\u00e9nt 10-25 mg-mal). A hirtelen abbahagy\u00e1s elvon\u00e1si t\u00fcneteket okozhat: \u00e1ltal\u00e1nos rossz k\u00f6z\u00e9rzet, hidegr\u00e1z\u00e1s, izzad\u00e1s, alv\u00e1szavar, em\u00e9szt\u0151rendszeri panaszok, \u00e9l\u00e9nk \u00e1lmok. Kellemetlen, de 1-2 h\u00e9t alatt \u00f6nmag\u00e1ban megsz\u0171nik. Soha ne hagyja abba hirtelen.<\/p>\n<h3 class=\"wp-block-heading\">Does Primox work for non-migraine headaches?<\/h3>\n<p>Igen \u2014 a triciklusos antidepressz\u00e1nsok az egyetlen bizony\u00edtottan hat\u00e9kony megel\u0151z\u0151 kezel\u00e9s a <strong>kr\u00f3nikus fesz\u00fclts\u00e9g t\u00edpus\u00fa fejf\u00e1j\u00e1s<\/strong>.  eset\u00e9ben. Seg\u00edtenek tov\u00e1bb\u00e1 a <strong>poszttraum\u00e1s fejf\u00e1j\u00e1s<\/strong>, <strong>gy\u00f3gyszer-f\u00e9lrehaszn\u00e1l\u00e1sb\u00f3l ered\u0151 fejf\u00e1j\u00e1st<\/strong> kezel\u00e9s\u00e9ben (a t\u00falzottan haszn\u00e1lt akut gy\u00f3gyszer elhagy\u00e1sa mellett), valamint a <strong>nyaki eredet\u0171 fejf\u00e1j\u00e1s<\/strong>.  eset\u00e9ben. Az amitriptilin a legjobban tanulm\u00e1nyozott triciklusos ezekben az indik\u00e1ci\u00f3kban; a nortriptilin hasonl\u00f3 hat\u00e9konys\u00e1g\u00fa, de jobb toler\u00e1lhat\u00f3s\u00e1g\u00fa.<\/p>\n<h3 class=\"wp-block-heading\">Where can I buy Primox online?<\/h3>\n<p>You can buy Primox (nortriptyline 25 mg, 30-180 tablet packs) from MedsBase with discreet packaging and worldwide shipping.<\/p>\n<h2 class=\"wp-block-heading\">Kapcsol\u00f3d\u00f3 migr\u00e9n kezel\u00e9sek a MedsBase-en<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/hu\/zolmist-nasal-spray\/\">Zolmist orrspray \u2014 Zolmitript\u00e1n 5 mg (gyors hat\u00e1s\u00fa)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/zolitas-ods\/\">Zolitas ODS \u2014 Zolmitript\u00e1n 2,5\/5 mg or\u00e1lisan diszperg\u00e1lhat\u00f3<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/maxtan\/\">Maxtan \u2014 Rizatript\u00e1n 5\/10 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/rizatop\/\">Rizatop \u2014 Rizatriptan 10 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/rizact\/\">Rizact \u2014 Rizatript\u00e1n (Cipla)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/sumitop\/\">Sumitop \u2014 Sumatriptan 25\/50\/100 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/anti-migraine\/\"><strong>\u00d6sszes migr\u00e9nkezel\u00e9s megtekint\u00e9se<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Orvosi nyilatkozat.<\/strong> Ez az oldal csak t\u00e1j\u00e9koztat\u00f3 jelleg\u0171, \u00e9s nem helyettes\u00edti az orvosi tan\u00e1csot. Mindig konzult\u00e1ljon orvos\u00e1val migr\u00e9n gy\u00f3gyszer szed\u00e9se el\u0151tt, m\u00f3dos\u00edt\u00e1sakor vagy abbahagy\u00e1sakor.<\/div>\n<h3>Mi\u00e9rt rendelj a MedsBase-r\u00f3l<\/h3>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Minden rendel\u00e9st fedez a <a href=\"https:\/\/medsbase.com\/hu\/medsbase-re-shipment-assurance-policy\/\"><strong>\u00dajrak\u00fcld\u00e9si Garancia<\/strong><\/a> \u2014 ha a csomagod nem \u00e9rkezik meg 20 munkanapon bel\u00fcl, \u00fajrak\u00fcldj\u00fck.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Kapcsol\u00f3d\u00f3 alternat\u00edv\u00e1k<\/h3>\n<p>Egy\u00e9b term\u00e9kek a <strong>Kr\u00f3nikus betegs\u00e9gek<\/strong> v\u00e1s\u00e1rl\u00f3k \u00e1ltal szint\u00e9n megtekintett term\u00e9kek:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/hu\/venpad-xr\/\">Venpad XR<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/atenheal\/\">Atenheal<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/endoxan\/\">Endoxan<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/tamodex\/\">Tamodex<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/meta-spray\/\">Meta Spray<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Primox is nortriptyline 25 mg oral tablets \u2014 the active secondary-amine metabolite of amitriptyline, with the same mechanism but roughly half the anticholinergic and sedative burden. Used for migraine prevention, chronic tension-type headache, neuropathic pain, fibromyalgia, and depression. Preferred tricyclic in elderly patients and where amitriptyline side effects are dose-limiting. Start 10 mg nightly; titrate to 25-75 mg for migraine prevention. Full effect at 8-12 weeks.<\/p>","protected":false},"featured_media":59501,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3553,3141,3223,4647],"product_tag":[4708,4709],"class_list":{"0":"post-59500","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-migraine","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_cat-situational-anxiety-treatment","10":"product_tag-nortriptyline","11":"product_tag-primox","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product\/59500","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/comments?post=59500"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/media\/59501"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/media?parent=59500"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product_brand?post=59500"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product_cat?post=59500"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product_tag?post=59500"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}