{"id":59683,"date":"2024-02-28T06:10:41","date_gmt":"2024-02-28T06:10:41","guid":{"rendered":"https:\/\/medsname.com\/udimax-300\/"},"modified":"2026-04-30T10:23:56","modified_gmt":"2026-04-30T10:23:56","slug":"udimax-300","status":"publish","type":"product","link":"https:\/\/medsbase.com\/hu\/product\/udimax-300\/","title":{"rendered":"Udimax 300"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Udimax 300?<\/h3>\n<p style=\"margin:0;\"><strong>Udimax 300<\/strong> is <strong>ursodeoxycholic acid (UDCA) 300 mg<\/strong> &mdash; a hydrophilic bile acid that is the standard of care for <strong>primary biliary cholangitis (PBC), cholesterol gallstones in patients unfit for surgery, intrahepatic cholestasis of pregnancy (ICP), bile-acid diarrhoea, and pruritus of cholestatic liver disease<\/strong>. UDCA reduces cholesterol saturation in bile, replaces toxic hydrophobic bile acids in the bile-acid pool, exerts cytoprotective and anti-apoptotic effects on hepatocytes and cholangiocytes, and stimulates bicarbonate-rich choleresis. Standard adult doses range from <strong>10&ndash;15 mg\/kg\/day for PBC and gallstones to 14&ndash;30 mg\/kg\/day for cholestasis of pregnancy<\/strong>. WHO-GMP min\u0151s\u00edt\u00e9s\u0171 gy\u00e1rt\u00f3.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f6f8;border:1px solid #e1e4e8;border-radius:6px;padding:14px 18px;margin:24px 0;font-size:14px;\"><strong>Mi\u00e9rt rendelj a MedsBase-t\u0151l?<\/strong> \u2714 <strong>WHO-GMP tan\u00fas\u00edtott gy\u00e1rt\u00f3<\/strong> \u2714 Diszkr\u00e9t csomagol\u00e1s \u2714 Vil\u00e1gszerte sz\u00e1ll\u00edt\u00e1s \u2714 <a href=\"https:\/\/medsbase.com\/hu\/reviews\/\">Hiteles\u00edtett v\u00e1s\u00e1rl\u00f3i v\u00e9lem\u00e9nyek (1 400+ v\u00e1s\u00e1rl\u00f3)<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Minden rendel\u00e9st fedez a <a href=\"https:\/\/medsbase.com\/hu\/medsbase-re-shipment-assurance-policy\/\"><strong>\u00dajrak\u00fcld\u00e9si Garancia<\/strong><\/a> \u2014 ha a csomagod nem \u00e9rkezik meg 20 munkanapon bel\u00fcl, \u00fajrak\u00fcldj\u00fck.<\/p>\n<h3>Mi\u00e9rt rendelj a MedsBase-r\u00f3l<\/h3>\n<p>Generikus gy\u00f3gyszereink WHO-GMP min\u0151s\u00edt\u00e9s\u0171 gy\u00e1rt\u00f3kt\u00f3l sz\u00e1rmaznak, \u00e9s diszkr\u00e9t, egyszer\u0171 csomagol\u00e1sban sz\u00e1ll\u00edtjuk \u0151ket vil\u00e1gszerte \u2014 a csomagon nem szerepel a gy\u00f3gyszer neve. A k\u00e1rty\u00e1s fizet\u00e9sek egy szab\u00e1lyozott feldolgoz\u00f3n kereszt\u00fcl t\u00f6rt\u00e9nnek (a sz\u00e1mlale\u00edr\u00e1sok egy szab\u00e1lyozott k\u00e1rtyafizet\u00e9si feldolgoz\u00f3t tartalmaznak \u2014 soha nem \u201cMedsBase\u201d vagy b\u00e1rmilyen gy\u00f3gyszer neve). Kriptovalut\u00e1t \u00e9s SEPA banki \u00e1tutal\u00e1st is elfogadunk. Minden rendel\u00e9st a Reshipment Assurance Policy biztos\u00edt\u00e9k fedez.<\/p>\n<div style=\"background:#f4f8fb;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>&#128161; First-line for PBC since 1994.<\/strong> UDCA is the only therapy proven to extend transplant-free survival in primary biliary cholangitis. In 30&ndash;40 percent of PBC patients ALP does not normalise on UDCA alone and obeticholic acid or a fibrate is added (specialist hepatology decision).<\/div>\n<h3 class=\"wp-block-heading\">Mi\u00e9rt rendelj a MedsBase-r\u00f3l<\/h3>\n<p>Udimax 300 is supplied from a <strong>WHO-GMP tan\u00fas\u00edtott gy\u00e1rt\u00f3<\/strong>. WHO-GMP min\u0151s\u00edt\u00e9s\u0171 gy\u00e1rt\u00f3t\u00f3l sz\u00e1rmazik. Minden rendel\u00e9st diszkr\u00e9ten sz\u00e1ll\u00edtunk vil\u00e1gszerte, \u00e9s <a href=\"https:\/\/medsbase.com\/hu\/medsbase-re-shipment-assurance-policy\/\">\u00dajrak\u00fcld\u00e9si Garancia<\/a> &mdash; if it does not arrive within 20 business days, we reship at no cost. UDCA has been on the WHO Essential Medicines List for decades and is the cornerstone of medical therapy for cholestatic liver disease.<\/p>\n<h2 class=\"wp-block-heading\">\u2014 ha 20 munkanapon bel\u00fcl nem \u00e9rkezik meg, ingyenesen \u00fajrak\u00fcldj\u00fck. Ez az egyetlen h\u00e1ny\u00e1sg\u00e1tl\u00f3 kombin\u00e1ci\u00f3, amely FDA A kateg\u00f3ri\u00e1j\u00fa st\u00e1tusszal rendelkezik a terhess\u00e9g alatt, \u00e9s az ACOG, a NICE \u00e9s a SOGC els\u0151vonalbeli aj\u00e1nl\u00e1sa a terhess\u00e9gi h\u00e1nyinger \u00e9s h\u00e1ny\u00e1s kezel\u00e9s\u00e9re.<\/h2>\n<p>UDCA is a naturally occurring hydrophilic 7&beta;-hydroxy bile acid (&#8220;the bear bile acid&#8221;). When taken orally it enriches the bile-acid pool, replacing toxic hydrophobic acids (chenodeoxycholic, lithocholic) that damage cholangiocytes and hepatocytes in cholestasis. Three actions matter clinically: (1) it reduces biliary cholesterol saturation, dissolving cholesterol gallstones over months; (2) it exerts direct cytoprotective and anti-apoptotic effects on liver cells, reducing immune-mediated damage in PBC; (3) it stimulates a bicarbonate-rich &#8220;alkaline tide&#8221; choleresis, which protects cholangiocytes from the detergent action of hydrophobic bile acids. Onset of biochemical improvement in PBC is typically 2&ndash;6 months.<\/p>\n<h2 class=\"wp-block-heading\">Indications &amp; doses<\/h2>\n<table border=\"1\" cellpadding=\"6\" style=\"border-collapse:collapse;width:100%;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th>Agoprex is a 25 mg agomelatine tablet supplied by Sun Pharma. Agomelatine is mechanistically unique among antidepressants: it acts as an agonist at melatonin MT1 and MT2 receptors and an antagonist at 5-HT2C serotonin receptors. The dual mechanism resynchronises disrupted circadian rhythms (a feature of major depression) while indirectly increasing dopamine and noradrenaline release in the frontal cortex.<\/th>\n<th>Dose<\/th>\n<th>Megjegyz\u00e9sek<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Primary biliary cholangitis (PBC)<\/td>\n<td>13&ndash;15 mg\/kg\/day in 1&ndash;2 divided doses<\/td>\n<td>\u00c9lethosszig tart\u00f3<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td>Cholesterol gallstones (radiolucent, non-calcified, &lt; 15 mm, functioning gallbladder)<\/td>\n<td>8&ndash;10 mg\/kg\/day<\/td>\n<td>6&ndash;24 months; recurrence common after stopping<\/td>\n<\/tr>\n<tr>\n<td>Intrahepatic cholestasis of pregnancy<\/td>\n<td>10&ndash;15 mg\/kg\/day, may rise to 25 mg\/kg\/day<\/td>\n<td>Reduces pruritus, normalises bile acids; PITCHES trial showed mixed effect on stillbirth<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td>Bile-acid diarrhoea<\/td>\n<td>250&ndash;500 mg twice daily (off-label)<\/td>\n<td>Combine with bile-acid binders (cholestyramine)<\/td>\n<\/tr>\n<tr>\n<td>PSC, cystic fibrosis liver disease, paediatric biliary atresia<\/td>\n<td>20&ndash;30 mg\/kg\/day<\/td>\n<td>Specialist supervision; high-dose in PSC limited to 20 mg\/kg\/day after a 30 mg\/kg trial showed harm<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Mell\u00e9khat\u00e1sok<\/h2>\n<ul>\n<li>Common: diarrhoea (dose-related), abdominal cramps, nausea<\/li>\n<li>Skin reactions (rash, pruritus &mdash; transient, opposite to its therapeutic effect on cholestatic itch)<\/li>\n<li>Calcified gallstones (rare; on long courses)<\/li>\n<li>Worsening ascites in advanced cirrhosis (rare)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Gy\u00f3gyszerk\u00f6lcs\u00f6nhat\u00e1sok<\/h2>\n<ul>\n<li><strong>Cholestyramine, colestipol, antacids (aluminium):<\/strong> bind UDCA and reduce absorption &mdash; separate by 2 hours.<\/li>\n<li><strong>Combined OC pill, oestrogens, clofibrate:<\/strong> increase biliary cholesterol saturation and oppose the gallstone-dissolution effect.<\/li>\n<li><strong>Ciclosporin:<\/strong> UDCA may improve ciclosporin absorption; monitor levels.<\/li>\n<li><strong>Nitrendipine, dapsone:<\/strong> levels may fall on UDCA &mdash; monitor.<\/li>\n<\/ul>\n<h2 id=\"faqs\">Gyakran Ism\u00e9telt K\u00e9rd\u00e9sek<\/h2>\n<h3 class=\"wp-block-heading\">Mennyi id\u0151 alatt l\u00e1that\u00f3 a javul\u00e1s?<\/h3>\n<p>In PBC, ALP and ALT begin to fall within 4&ndash;8 weeks; full biochemical response is judged at 12 months. Pruritus often improves within weeks. Gallstone dissolution takes 6&ndash;24 months and only works for cholesterol stones.<\/p>\n<h3 class=\"wp-block-heading\">Will it dissolve all gallstones?<\/h3>\n<p>No. Only radiolucent, non-calcified, cholesterol stones &lt; 15 mm in a functioning gallbladder will dissolve. Pigment stones, calcified stones, and cholecystitis will not respond. Recurrence after stopping is common (~50 percent in 5 years) so cholecystectomy remains preferred when feasible.<\/p>\n<h3 class=\"wp-block-heading\">Biztons\u00e1gos terhess\u00e9g alatt?<\/h3>\n<p>Yes. UDCA is the recognised therapy for intrahepatic cholestasis of pregnancy (ICP), reducing maternal pruritus and bile-acid levels. Discuss with obstetric prescriber.<\/p>\n<h3 class=\"wp-block-heading\">Ihatok alkoholt k\u00f6zben?<\/h3>\n<p>Avoid heavy alcohol &mdash; it worsens any underlying liver disease. Light intake is acceptable in PBC at the prescriber&#8217;s discretion.<\/p>\n<h3 class=\"wp-block-heading\">Why do I have diarrhoea?<\/h3>\n<p>Excess UDCA reaches the colon and acts as an osmotic \/ secretory laxative. Splitting the dose (e.g. 300 mg morning and evening rather than 600 mg once) usually helps. If persistent, dose reduction is reasonable in stone-dissolution use; in PBC, prioritise the dose for biochemical response.<\/p>\n<h3 class=\"wp-block-heading\">Will I need it for life?<\/h3>\n<p>In PBC: yes. In gallstones: only until they dissolve (then stop, accept recurrence risk). In ICP: until delivery and normalisation of bile acids.<\/p>\n<h3 class=\"wp-block-heading\">\u00c9tellel egy\u00fctt kell bevenni?<\/h3>\n<p>Take with meals. Bile-acid recycling during the postprandial period maximises enterohepatic circulation and the therapeutic effect.<\/p>\n<h3 class=\"wp-block-heading\">Can I take it with cholestyramine?<\/h3>\n<p>Yes, but separate by 2 hours &mdash; cholestyramine binds bile acids and would inactivate the dose if taken simultaneously.<\/p>\n<h3 class=\"wp-block-heading\">T\u00e1rol\u00e1s<\/h3>\n<p>Below 25&deg;C, dry place. Keep tablets in the original blister.<\/p>\n<h3 class=\"wp-block-heading\">Mi a teend\u0151, ha kihagyok egy adagot?<\/h3>\n<p>Vegye be, amint esz\u00e9be jut. Ha k\u00f6zel van a k\u00f6vetkez\u0151 adaghoz, hagyja ki. Ne dupl\u00e1zza meg az adagot.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Egy\u00e9b Gasztroenterol\u00f3giai Gy\u00f3gyszerek<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/hu\/maxiliv-injection\/\">Maxiliv Injection &mdash; Glutathione (antioxidant)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/liv-52-ds\/\">Liv 52 DS \u2014 Ajurv\u00e9d\u00e1s m\u00e1jv\u00e9d\u0151<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/asacol\/\">Asacol &mdash; Mesalamine 400 mg (UC)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/saaz\/\">Saaz &mdash; Sulfasalazine<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/budez-cr\/\">Budez CR &mdash; Budesonide CR (autoimmune hepatitis off-label)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/gastro-health\/\"><strong>\u00d6sszes Gasztroenterol\u00f3giai Gy\u00f3gyszer Tall\u00f3z\u00e1sa<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Orvosi nyilatkozat.<\/strong> This page is for informational purposes only and does not replace medical advice from a qualified healthcare professional. PBC, PSC, ICP, and cholestatic liver disease all need specialist hepatology supervision. Acute right-upper-quadrant pain, jaundice, fever, or pale stools needs urgent assessment.<\/div>","protected":false},"excerpt":{"rendered":"<p>Udimax 300 (Ursodeoxycholic Acid 300 mg) \u2014 hydrophilic bile acid for primary biliary cholangitis, cholesterol gallstones, intrahepatic cholestasis of pregnancy, and bile-acid diarrhoea. WHO Essential Medicine for PBC. Worldwide shipping from MedsBase.<\/p>","protected":false},"featured_media":59684,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3542,3342],"product_tag":[4727,4728],"class_list":{"0":"post-59683","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-gastro-health","8":"product_cat-general-health","9":"product_tag-udimax-300","10":"product_tag-ursodeoxycholic-acid","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product\/59683","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/comments?post=59683"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/media\/59684"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/media?parent=59683"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product_brand?post=59683"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product_cat?post=59683"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product_tag?post=59683"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}