{"id":59919,"date":"2024-02-28T06:23:55","date_gmt":"2024-02-28T06:23:55","guid":{"rendered":"https:\/\/medsname.com\/ondem-md\/"},"modified":"2026-04-30T10:23:53","modified_gmt":"2026-04-30T10:23:53","slug":"ondem-md","status":"publish","type":"product","link":"https:\/\/medsbase.com\/hu\/product\/ondem-md\/","title":{"rendered":"Ondem MD"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Ondem MD?<\/h3>\n<p style=\"margin:0;\"><strong>Ondem MD<\/strong> egy <strong>orally disintegrating tablet (ODT\/MD)<\/strong> of <strong>ondansetron 4 mg \/ 8 mg<\/strong>, a selective serotonin <strong>5-HT3 receptor antagonist<\/strong>. It is the most-used antiemetic worldwide and works against the strong serotonergic emetic stimulus generated by chemotherapy, radiation, surgery, gastroenteritis, and migraine. Manufactured by Alkem under WHO-GMP standards. Onset within 30 minutes orally and 8&ndash;12 hour duration; usually given 30&ndash;60 minutes before chemo or as needed for breakthrough nausea.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f6f8;border:1px solid #e1e4e8;border-radius:6px;padding:14px 18px;margin:24px 0;font-size:14px;\"><strong>Mi\u00e9rt rendelj a MedsBase-t\u0151l?<\/strong> \u2714 <strong>WHO-GMP tan\u00fas\u00edtott gy\u00e1rt\u00f3<\/strong> \u2714 Diszkr\u00e9t csomagol\u00e1s \u2714 Vil\u00e1gszerte sz\u00e1ll\u00edt\u00e1s \u2714 <a href=\"https:\/\/medsbase.com\/hu\/reviews\/\">Hiteles\u00edtett v\u00e1s\u00e1rl\u00f3i v\u00e9lem\u00e9nyek (1 400+ v\u00e1s\u00e1rl\u00f3)<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Minden rendel\u00e9st fedez a <a href=\"https:\/\/medsbase.com\/hu\/medsbase-re-shipment-assurance-policy\/\"><strong>\u00dajrak\u00fcld\u00e9si Garancia<\/strong><\/a> \u2014 ha a csomagod nem \u00e9rkezik meg 20 munkanapon bel\u00fcl, \u00fajrak\u00fcldj\u00fck.<\/p>\n<h3>Mi\u00e9rt rendelj a MedsBase-r\u00f3l<\/h3>\n<p>Generikus gy\u00f3gyszereink WHO-GMP min\u0151s\u00edt\u00e9s\u0171 gy\u00e1rt\u00f3kt\u00f3l sz\u00e1rmaznak, \u00e9s diszkr\u00e9t, egyszer\u0171 csomagol\u00e1sban sz\u00e1ll\u00edtjuk \u0151ket vil\u00e1gszerte \u2014 a csomagon nem szerepel a gy\u00f3gyszer neve. A k\u00e1rty\u00e1s fizet\u00e9sek egy szab\u00e1lyozott feldolgoz\u00f3n kereszt\u00fcl t\u00f6rt\u00e9nnek (a sz\u00e1mlale\u00edr\u00e1sok egy szab\u00e1lyozott k\u00e1rtyafizet\u00e9si feldolgoz\u00f3t tartalmaznak \u2014 soha nem \u201cMedsBase\u201d vagy b\u00e1rmilyen gy\u00f3gyszer neve). Kriptovalut\u00e1t \u00e9s SEPA banki \u00e1tutal\u00e1st is elfogadunk. Minden rendel\u00e9st a Reshipment Assurance Policy biztos\u00edt\u00e9k fedez.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>&#9888;&#65039; Ondansetron QT-prolongation FDA dose cap.<\/strong> A single IV dose &gt; 16 mg has been associated with QT prolongation and torsades-de-pointes. Maximum single dose is 16 mg IV (oral 24 mg single dose has a slightly different cap). Avoid in <strong>congenital long-QT<\/strong>, hypokalaemia, hypomagnesaemia, or with other QT-prolonging drugs (azithromycin, citalopram, methadone, hydroxychloroquine, amiodarone, fluoroquinolones, antipsychotics). Apomorphine is an absolute contraindication (severe hypotension).<\/div>\n<h2 class=\"wp-block-heading\">When ondansetron is the right antiemetic<\/h2>\n<p>Ondansetron is the <strong>first-line antiemetic for serotonin-driven nausea<\/strong> &mdash; chemotherapy-induced nausea and vomiting (CINV), post-operative nausea and vomiting (PONV), radiation-induced nausea, and severe gastroenteritis. It is <strong>less useful for motion sickness and vestibular nausea<\/strong> (where the dominant pathway is histaminergic and cholinergic &mdash; promethazine\/Avomine, cinnarizine, and meclozine work better) and <strong>not first-line for nausea-vomiting of pregnancy<\/strong> (NVP first-line is doxylamine + B6; ondansetron is reserved for refractory hyperemesis gravidarum after considering a small first-trimester cardiac\/cleft-palate signal in observational studies).<\/p>\n<h3 class=\"wp-block-heading\">Mi\u00e9rt rendelj a MedsBase-r\u00f3l<\/h3>\n<p>Ondem MD is supplied from a <strong>WHO-GMP tan\u00fas\u00edtott gy\u00e1rt\u00f3<\/strong>. WHO-GMP min\u0151s\u00edt\u00e9s\u0171 gy\u00e1rt\u00f3t\u00f3l sz\u00e1rmazik. Minden rendel\u00e9st diszkr\u00e9ten sz\u00e1ll\u00edtunk vil\u00e1gszerte, \u00e9s <a href=\"https:\/\/medsbase.com\/hu\/medsbase-re-shipment-assurance-policy\/\">\u00dajrak\u00fcld\u00e9si Garancia<\/a> &mdash; if it does not arrive within 20 business days, we reship at no cost. Ondansetron is the global standard for serotonin-driven emesis with millions of doses delivered safely each year. Orally disintegrating tablet (ODT\/MD) formulation is convenient when active vomiting prevents reliable swallowing.<\/p>\n<h2 class=\"wp-block-heading\">Az albendazol k\u00f6t\u0151dik<\/h2>\n<p>Chemotherapy, radiation, and surgery damage gut enterochromaffin cells, which release massive amounts of <strong>serotonin (5-HT)<\/strong>. The serotonin binds 5-HT3 receptors on vagal afferents and on the chemoreceptor trigger zone (area postrema), which signal the medullary vomiting centre. Ondansetron is a highly selective antagonist at the 5-HT3 receptor &mdash; it blocks this signal at both peripheral and central sites without affecting D2, H1, muscarinic, or alpha-adrenergic receptors. That selectivity explains its clean side-effect profile: minimal sedation, no extrapyramidal reactions, no anticholinergic burden.<\/p>\n<h2 class=\"wp-block-heading\">Indik\u00e1ci\u00f3k<\/h2>\n<ul>\n<li><strong>CINV:<\/strong> moderately or highly emetogenic chemotherapy (cisplatin, anthracyclines, cyclophosphamide regimens) &mdash; usually with dexamethasone &plusmn; aprepitant for highly emetogenic regimens.<\/li>\n<li><strong>Sug\u00e1rkezel\u00e9s \u00e1ltal kiv\u00e1ltott h\u00e1nyinger:<\/strong> teljes testbesug\u00e1rz\u00e1s, magas d\u00f3zis\u00fa hasi sug\u00e1rkezel\u00e9s.<\/li>\n<li><strong>M\u0171t\u00e9t ut\u00e1ni h\u00e1ny\u00e1s \u00e9s h\u00e1nyinger (PONV):<\/strong> single 4 mg dose at induction or end of surgery.<\/li>\n<li><strong>Severe gastroenteritis:<\/strong> dehydration risk in children\/adults.<\/li>\n<li><strong>Migraine-associated nausea:<\/strong> often with sumatriptan or other triptans.<\/li>\n<li><strong>Refractory hyperemesis gravidarum:<\/strong> after first-line doxylamine+B6 (Doxinate, Pregnidoxin NU) and metoclopramide have failed; specialist supervision recommended.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Dose<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;\">Agoprex is a 25 mg agomelatine tablet supplied by Sun Pharma. Agomelatine is mechanistically unique among antidepressants: it acts as an agonist at melatonin MT1 and MT2 receptors and an antagonist at 5-HT2C serotonin receptors. The dual mechanism resynchronises disrupted circadian rhythms (a feature of major depression) while indirectly increasing dopamine and noradrenaline release in the frontal cortex.<\/th>\n<th style=\"padding:8px;text-align:left;\">Dose<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">CINV (adult)<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">8 mg 30 min before chemo, then 8 mg every 8&ndash;12 h for up to 5 days<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">PONV (adult)<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">4 mg single dose, IV at induction or oral 1 h pre-op<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Severe gastroenteritis (adult)<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">4&ndash;8 mg every 8 h as needed (max 24 mg\/day)<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Paediatric (4&ndash;11 y, gastro)<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">4 mg every 8 h (8&ndash;15 kg: 2 mg; 15&ndash;30 kg: 4 mg; &gt;30 kg: 4&ndash;8 mg)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">S\u00falyos m\u00e1jel\u00e9gtelens\u00e9g<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Maximum 8 mg\/day (Child-Pugh C)<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Single-dose maximum<\/td>\n<td style=\"padding:8px;\">16 mg IV; 24 mg oral &mdash; do not exceed<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Place the ODT on a dry tongue; it dissolves in 10&ndash;30 seconds with saliva. Do not push through the foil &mdash; peel back. No water needed, useful for active vomiting.<\/p>\n<h2 class=\"wp-block-heading\">Mell\u00e9khat\u00e1sok<\/h2>\n<ul>\n<li><strong>Gyakori (&gt; 10%):<\/strong> headache, constipation (the most clinically meaningful side effect &mdash; pre-empt with hydration and stool softener if multi-day course)<\/li>\n<li><strong>Gyakori (1\u201310%):<\/strong> mild flushing, fatigue, transient AST\/ALT rise, dizziness, hot flushes after IV<\/li>\n<li><strong>Kevesebb gyakoris\u00e1ggal:<\/strong> bradycardia, hypotension, myalgia<\/li>\n<li><strong>Ritka, de s\u00falyos:<\/strong> QT prolongation\/torsades, serotonin syndrome (with SSRIs\/SNRIs\/triptans\/MAOIs), severe hypersensitivity, transient blindness (very rare, with rapid IV)<\/li>\n<li><strong>Nem gyakori:<\/strong> extrapyramidal reactions (rare with ondansetron unlike older antiemetics)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Gy\u00f3gyszerk\u00f6lcs\u00f6nhat\u00e1sok<\/h2>\n<ul>\n<li><strong>Apomorphine:<\/strong> ABSOLUTE contraindication &mdash; severe hypotension and loss of consciousness reported.<\/li>\n<li><strong>Egy\u00e9b QT-idej\u00e9t meghosszabb\u00edt\u00f3 gy\u00f3gyszerek<\/strong> (azithromycin, clarithromycin, citalopram, escitalopram, methadone, amiodarone, sotalol, fluoroquinolones, hydroxychloroquine, antipsychotics): avoid combination or monitor ECG.<\/li>\n<li><strong>Szerotonerg gy\u00f3gyszerek<\/strong> (SSRIs, SNRIs, MAOIs, triptans, tramadol, fentanyl, linezolid, methylene blue): rare serotonin syndrome reported &mdash; counsel patients to recognise tremor\/agitation\/clonus\/hyperthermia.<\/li>\n<li><strong>Tramadol:<\/strong> ondansetron may reduce tramadol analgesic effect (5-HT3 blockade interferes with descending pain inhibition).<\/li>\n<li><strong>Er\u0151s CYP3A4 induk\u00e1l\u00f3k<\/strong> (rifampicin, phenytoin, carbamazepine): can lower ondansetron levels and reduce efficacy.<\/li>\n<\/ul>\n<h2 id=\"faqs\">Gyakran Ism\u00e9telt K\u00e9rd\u00e9sek<\/h2>\n<h3 class=\"wp-block-heading\">How quickly does Ondem MD work?<\/h3>\n<p>Ondansetron ODTs reach therapeutic plasma levels in about 30 minutes after dissolution. Onset of antiemetic effect is similar to swallowed tablets; the ODT advantage is reliability when vomiting is active.<\/p>\n<h3 class=\"wp-block-heading\">Is Ondem MD safe in pregnancy?<\/h3>\n<p>Ondansetron is reserved for <strong>refractory hyperemesis gravidarum<\/strong> after doxylamine+B6 (Doxinate, Pregnidoxin NU), pyridoxine, and metoclopramide have failed. Some observational studies suggest a small first-trimester cardiac and cleft-palate signal; use should be discussed with a clinician.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Ondem MD for motion sickness?<\/h3>\n<p>Ondansetron works on the serotonin pathway and is <strong>not effective for motion sickness<\/strong>, which is histaminergic\/cholinergic. Use promethazine (Avomine), cinnarizine, meclozine, or a hyoscine patch instead.<\/p>\n<h3 class=\"wp-block-heading\">How is Ondem MD different from metoclopramide or domperidone?<\/h3>\n<p>Metoclopramide and domperidone are <strong>D2 antagonists<\/strong> &mdash; they speed gastric emptying and treat dyspepsia\/regurgitation\/gastroparesis nausea. Ondansetron is a <strong>5-HT3 antagonist<\/strong> &mdash; better for chemo, radiation, surgery, severe gastroenteritis, and migraine nausea. Ondansetron is more expensive but cleaner (no extrapyramidal reactions, no hyperprolactinaemia).<\/p>\n<h3 class=\"wp-block-heading\">Does Ondem MD cause drowsiness?<\/h3>\n<p>No. Unlike promethazine, prochlorperazine, and metoclopramide, ondansetron does not cause sedation or confusion and is preferred for ambulatory or driving patients.<\/p>\n<h3 class=\"wp-block-heading\">What is the maximum dose?<\/h3>\n<p>Maximum single oral dose is 24 mg; maximum single IV dose is 16 mg (FDA cap). Total daily dose typically 24 mg\/day; in severe hepatic impairment cap at 8 mg\/day.<\/p>\n<h3 class=\"wp-block-heading\">Can I take it with my SSRI antidepressant?<\/h3>\n<p>Short-term combinations are usually safe but counsel patients to recognise serotonin syndrome (tremor, agitation, hyperreflexia, clonus, fever). Long-term concurrent use is generally avoided when an alternative antiemetic is available.<\/p>\n<h3 class=\"wp-block-heading\">Probl\u00e9ma lehet a sz\u00e9kreked\u00e9s?<\/h3>\n<p>Yes &mdash; ondansetron causes constipation in up to 1 in 10 users (more on multi-day chemo courses). Maintain hydration, fibre, and a stimulant laxative (senna\/bisacodyl) prophylactically during chemo cycles.<\/p>\n<h3 class=\"wp-block-heading\">Can Ondem MD be used in children?<\/h3>\n<p>Yes &mdash; weight-based dosing is well established for paediatric gastroenteritis (8&ndash;15 kg = 2 mg, 15&ndash;30 kg = 4 mg, &gt;30 kg = 4&ndash;8 mg every 8 h). The ODT formulation is particularly useful for children who cannot swallow tablets.<\/p>\n<h3 class=\"wp-block-heading\">How is Ondem MD stored?<\/h3>\n<p>Store at room temperature (below 30&deg;C), protect from light and moisture, keep out of reach of children. Keep ODT blisters sealed until use; do not refrigerate.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Egy\u00e9b h\u00e1nyinger elleni kezel\u00e9sek<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/hu\/ondem-injection\/\">Ondem Injection (ondansetron 2 mg\/ml IV\/IM)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/granicip\/\">Granicip (granisetron &mdash; longer-acting 5-HT3)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/dompewal-tablet\/\">Dompewal (domperidone &mdash; D2 antagonist for regurgitation)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/stemetil-md\/\">Stemetil MD (prochlorperazine ODT &mdash; vestibular nausea)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/avomine\/\">Avomine (promethazine &mdash; motion sickness)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/nausea-treatment\/\"><strong>\u00d6sszes h\u00e1nyinger elleni kezel\u00e9s b\u00f6ng\u00e9sz\u00e9se<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Orvosi nyilatkozat.<\/strong> Ez az oldal csak t\u00e1j\u00e9koztat\u00f3 jelleg\u0171, \u00e9s nem helyettes\u00edti a min\u0151s\u00edtett eg\u00e9szs\u00e9g\u00fcgyi szakember \u00e1ltal ny\u00fajtott orvosi tan\u00e1csot. Tart\u00f3s h\u00e1ny\u00e1s, v\u00e9r a h\u00e1nyad\u00e9kban, s\u00falyos hasi f\u00e1jdalom, dehidr\u00e1ci\u00f3 jelei, terhess\u00e9gi sz\u00f6v\u0151dm\u00e9nyek gyan\u00faja vagy kemoter\u00e1pi\u00e1val kapcsolatos t\u00fcnetek eset\u00e9n klinikai \u00e9rt\u00e9kel\u00e9s sz\u00fcks\u00e9ges.<\/div>","protected":false},"excerpt":{"rendered":"<p>Ondem MD (Ondansetron 4 mg \/ 8 mg orally disintegrating) \u2014 selective 5-HT3 antagonist for chemo, radiation, and PONV. Dissolves on the tongue without water.<\/p>","protected":false},"featured_media":59920,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3543],"product_tag":[3613,4767],"class_list":{"0":"post-59919","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-nausea-treatment","9":"product_tag-ondansetron","10":"product_tag-ondem-md","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product\/59919","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/comments?post=59919"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/media\/59920"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/media?parent=59919"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product_brand?post=59919"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product_cat?post=59919"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product_tag?post=59919"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}