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Dilantin<\/strong> or\u00e1lis phenytoin sodium<\/strong> (100 mg) extended-release capsule \u2014 a first-generation hydantoin anticonvulsant<\/strong> alkalmazott tonic-clonic (grand mal) seizures<\/strong>, complex partial seizures<\/strong>, \u00e9s seizure prevention after neurosurgery<\/strong>. It works by blocking voltage-gated sodium channels in neurons, stabilising the inactivated state and preventing repetitive firing. Usual adult dose: 300–400 mg\/day<\/strong> in 1–2 divided doses (extended-release allows once-daily dosing). Therapeutic range: 10–20 µg\/mL<\/strong> \u2014 requires monitoring due to nonlinear (saturable) pharmacokinetics<\/strong>. Common side effects: gingival hyperplasia, ataxia, nystagmus, hirsutism, coarsening of facial features. Many drug interactions via CYP2C9\/2C19 induction.<\/p>\n<\/div>\n \ud83d\udce6 Minden rendel\u00e9st fedez a \u00dajrak\u00fcld\u00e9si Garancia<\/strong><\/a> \u2014 ha a csomagod nem \u00e9rkezik meg 20 munkanapon bel\u00fcl, \u00fajrak\u00fcldj\u00fck.<\/p>\n Generikus gy\u00f3gyszereink WHO-GMP min\u0151s\u00edt\u00e9s\u0171 gy\u00e1rt\u00f3kt\u00f3l sz\u00e1rmaznak, \u00e9s diszkr\u00e9t, egyszer\u0171 csomagol\u00e1sban sz\u00e1ll\u00edtjuk \u0151ket vil\u00e1gszerte \u2014 a csomagon nem szerepel a gy\u00f3gyszer neve. A k\u00e1rty\u00e1s fizet\u00e9sek egy szab\u00e1lyozott feldolgoz\u00f3n kereszt\u00fcl t\u00f6rt\u00e9nnek (a sz\u00e1mlale\u00edr\u00e1sok egy szab\u00e1lyozott k\u00e1rtyafizet\u00e9si feldolgoz\u00f3t tartalmaznak \u2014 soha nem \u201cMedsBase\u201d vagy b\u00e1rmilyen gy\u00f3gyszer neve). Kriptovalut\u00e1t \u00e9s SEPA banki \u00e1tutal\u00e1st is elfogadunk. Minden rendel\u00e9st a Reshipment Assurance Policy biztos\u00edt\u00e9k fedez.<\/p>\n Dilantin is an oral extended-release capsule containing phenytoin sodium 100 mg<\/strong>. Phenytoin is one of the oldest and most widely used anticonvulsants, in continuous clinical use since 1938<\/strong> — making it one of the most extensively studied drugs in medicine.<\/p>\n Phenytoin stabilises neuronal membranes by blocking voltage-gated sodium channels, preventing the repetitive firing that underlies seizure propagation. It is on the WHO alapvet\u0151 gy\u00f3gyszereinek list\u00e1j\u00e1ra<\/strong> and remains a first-line option for tonic-clonic<\/strong> \u00e9s focal seizures<\/strong>. Dilantin is the original brand developed by Parke-Davis (now Pfizer) and is the reference standard for all phenytoin generics.<\/p>\n Phenytoin is unique among anticonvulsants for its zero-order (saturable) kinetics<\/strong> at therapeutic doses: small dose changes can produce disproportionately large changes in blood levels. This is why therapeutic drug monitoring (TDM)<\/strong> is mandatory with phenytoin — a feature that makes it more demanding to prescribe than newer agents but also the most fine-tuneable when used by experienced clinicians.<\/p>\n Phenytoin blocks voltage-gated sodium channels<\/strong> by preferentially binding to their inactivated state. This prolongs the refractory period of neurons, preventing the rapid repetitive firing that underlies seizure propagation. Unlike newer anticonvulsants that act on multiple targets, phenytoin is a relatively selective sodium-channel blocker.<\/p>\n Critically, phenytoin exhibits nonlinear (zero-order, saturable) pharmacokinetics<\/strong> described by the Michaelis-Menten equation. This means small dose increases near saturation can produce disproportionately large<\/strong> rises in blood levels, making therapeutic drug monitoring essential.<\/p>\nMi\u00e9rt rendelj a MedsBase-r\u00f3l<\/h3>\n
What Is Dilantin?<\/h2>\n
How Does Dilantin (Phenytoin) Work?<\/h2>\n
Indik\u00e1ci\u00f3k<\/h2>\n
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Dosing and Therapeutic Drug Monitoring<\/h2>\n