{"id":60749,"date":"2024-02-28T07:06:28","date_gmt":"2024-02-28T07:06:28","guid":{"rendered":"https:\/\/medsname.com\/temozol-20\/"},"modified":"2026-04-30T10:23:43","modified_gmt":"2026-04-30T10:23:43","slug":"temozol-20","status":"publish","type":"product","link":"https:\/\/medsbase.com\/hu\/product\/temozol-20\/","title":{"rendered":"Temozol 20"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Temozol?<\/h3>\n<p style=\"margin:0;\"><strong>Temozolomid<\/strong> is an oral capsule from Cipla containing <strong>temozolomide<\/strong> itt <strong>20 mg<\/strong> &mdash; an oral alkylating cytotoxic agent and the standard chemotherapy for <strong>glioblastoma multiforme (GBM)<\/strong> \u00e9s <strong>anaplastic astrocytoma<\/strong>. Standard regimen: <strong>concurrent<\/strong> with radiotherapy (75 mg\/m&sup2; daily for 6 weeks), then <strong>maintenance<\/strong> 150&ndash;200 mg\/m&sup2; daily for days 1&ndash;5 of each 28-day cycle for 6 cycles (Stupp protocol). <strong>\u00dcres gyomorral szedend\u0151<\/strong> at the same time each day, with antiemetic (ondansetron) 1 hour before. Mandatory: <strong>PCP megel\u0151z\u00e9s<\/strong> with co-trimoxazole during radiotherapy phase. FBC weekly during concurrent phase, then before each maintenance cycle.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Mit kapsz a MedsBase-n\u00e1l:<\/strong> WHO-GMP min\u0151s\u00edt\u00e9s\u0171 gy\u00e1rt\u00f3 \u00b7 Diszkr\u00e9t csomagol\u00e1s \u00b7 Vil\u00e1gszerte sz\u00e1ll\u00edt\u00e1s \u00b7 1.400+ hiteles\u00edtett <a href=\"https:\/\/medsbase.com\/hu\/reviews\/\">v\u00e1s\u00e1rl\u00f3i v\u00e9lem\u00e9ny<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Minden rendel\u00e9st fedez a <a href=\"https:\/\/medsbase.com\/hu\/medsbase-re-shipment-assurance-policy\/\"><strong>\u00dajrak\u00fcld\u00e9si Garancia<\/strong><\/a> \u2014 ha a csomagod nem \u00e9rkezik meg 20 munkanapon bel\u00fcl, \u00fajrak\u00fcldj\u00fck.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;\"><strong>\u26a0 Szakorvosi fel\u00fcgyelet sz\u00fcks\u00e9ges.<\/strong> A r\u00e1kk\u00e9sz\u00edtm\u00e9nyeket csak kezel\u0151 onkol\u00f3gus \u00edrhatja fel meger\u0151s\u00edtett diagn\u00f3zis, kiindul\u00e1si st\u00e1diummeghat\u00e1roz\u00e1s \u00e9s meghat\u00e1rozott kezel\u00e9si terv mellett. Soha ne kezdjen el, ne szak\u00edtson meg, ne m\u00f3dos\u00edtson adagot, \u00e9s ne haszn\u00e1ljon r\u00e1kk\u00e9sz\u00edtm\u00e9nyt onkol\u00f3giai ell\u00e1t\u00e1si terven k\u00edv\u00fcl. A legt\u00f6bb r\u00e1kk\u00e9sz\u00edtm\u00e9ny rendszeres v\u00e9rvizsg\u00e1lati monitoroz\u00e1st ig\u00e9nyel (teljes v\u00e9rk\u00e9p, m\u00e1jfunkci\u00f3, vesefunkci\u00f3), abszol\u00fat kontraindik\u00e1lt terhess\u00e9g alatt, \u00e9s jelent\u0151s gy\u00f3gyszerk\u00f6lcs\u00f6nhat\u00e1sokkal rendelkezik.<\/div>\n<div style=\"background:#f4f8fb;border:1px solid #d6e4ec;padding:12px 18px;margin:14px 0;border-radius:4px;font-size:14px;color:#3a5160;text-align:center;\">\n<strong>\ud83d\udd12 Titkos\u00edtott fizet\u00e9s<\/strong> \u00b7 <strong>\ud83d\udcb3 Hiteles\u00edtett feldolgoz\u00f3<\/strong> \u00b7 <strong>\ud83d\ude9a Vil\u00e1gszerte sz\u00e1ll\u00edtunk<\/strong> \u00b7 <strong>\u2b50 4,9\/5 1400+ \u00fcgyf\u00e9lt\u0151l<\/strong>\n<\/div>\n<h2 class=\"wp-block-heading\">What Is Temozol?<\/h2>\n<p>Temozol is an oral capsule from Cipla containing <strong>temozolomide<\/strong> (20 mg). Temozolomide is an oral alkylating cytotoxic agent of the imidazotetrazine class. It crosses the blood-brain barrier (CSF concentration ~30% of plasma) and is the only oral cytotoxic with proven survival benefit in glioblastoma multiforme. Standard combination with radiotherapy (the &ldquo;Stupp protocol&rdquo;, 2005) extended median GBM survival from 12 months to 15 months and 2-year survival from 11% to 27%.<\/p>\n<h2 class=\"wp-block-heading\">Felhaszn\u00e1l\u00e1s \u00e9s indik\u00e1ci\u00f3k<\/h2>\n<ul>\n<li><strong>Newly-diagnosed glioblastoma multiforme (GBM)<\/strong> &mdash; concurrent with radiotherapy then maintenance (Stupp protocol)<\/li>\n<li><strong>Anaplastic astrocytoma<\/strong> after recurrence<\/li>\n<li><strong>Recurrent high-grade glioma<\/strong><\/li>\n<li><strong>Off-label alkalmaz\u00e1s:<\/strong> melanoma brain metastases, neuroendocrine tumours<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Dosage (Stupp protocol)<\/h2>\n<ul>\n<li><strong>Concurrent phase:<\/strong> 75 mg\/m&sup2;\/day continuously during 6 weeks of radiotherapy (total ~42 days)<\/li>\n<li><strong>4-week break<\/strong> after radiotherapy completion<\/li>\n<li><strong>Karbantart\u00e1si szakasz:<\/strong> 150 mg\/m&sup2;\/day for days 1&ndash;5 of a 28-day cycle (cycle 1); escalate to 200 mg\/m&sup2;\/day if tolerated for cycles 2&ndash;6 (total 6 cycles, with newer evidence supporting up to 12 cycles in younger MGMT-methylated patients)<\/li>\n<\/ul>\n<ol>\n<li><strong>Take on an empty stomach at the same time each day<\/strong> &mdash; food slows absorption and reduces peak concentration. Most patients take it at bedtime, &ge; 2 hours after the last meal.<\/li>\n<li><strong>Antiemetic:<\/strong> ondansetron 8 mg orally 1 hour before each temozolomide dose, especially during the maintenance phase 5-day pulse.<\/li>\n<li>Swallow capsules whole with water. Do NOT open or chew &mdash; powder is cytotoxic.<\/li>\n<li><strong>PCP megel\u0151z\u00e9s<\/strong> with co-trimoxazole 480 mg three times weekly during the concurrent phase &mdash; lymphopenia risk. Continue until CD4 &gt; 200 cells\/&micro;L.<\/li>\n<li><strong>K\u00f6telez\u0151 monitoroz\u00e1s:<\/strong> FBC weekly during concurrent phase; before each maintenance cycle (day 22 of previous cycle and day 1 of each new cycle); LFTs monthly. Hold cycle for ANC &lt; 1,500\/&micro;L or platelets &lt; 100,000\/&micro;L.<\/li>\n<li>If a dose is vomited within 1 hour, do NOT re-dose. Resume next day per schedule.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Mell\u00e9khat\u00e1sok<\/h2>\n<p><strong>Gyakori:<\/strong> nausea, vomiting (mostly preventable with ondansetron), fatigue, anorexia, constipation, headache, alopecia.<\/p>\n<p><strong>Fontos:<\/strong><\/p>\n<ul>\n<li><strong>Mieloszuppresszi\u00f3<\/strong> &mdash; especially thrombocytopenia (the dose-limiting toxicity); lymphopenia with PCP risk<\/li>\n<li><strong>Pneumocystis jirovecii t\u00fcd\u0151gyullad\u00e1s<\/strong> &mdash; lymphopenia-driven; mandatory prophylaxis during concurrent phase<\/li>\n<li>Hepatotoxicity, including rare reactivation of hepatitis B<\/li>\n<li>Severe skin reactions including SJS\/TEN (rare)<\/li>\n<li>Secondary myelodysplastic syndrome \/ acute leukaemia (rare, long-term)<\/li>\n<li>Severe lymphopenia &gt; 6 months<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Figyelmeztet\u00e9sek<\/h2>\n<ul>\n<li><strong>Terhess\u00e9g:<\/strong> teratogenic. Reliable contraception throughout treatment + 6 months after.<\/li>\n<li><strong>Szoptat\u00e1s:<\/strong> Ker\u00fclend\u0151.<\/li>\n<li><strong>S\u00falyos m\u00e1jk\u00e1rosod\u00e1s:<\/strong> Ker\u00fclend\u0151.<\/li>\n<li><strong>Hepatitis B carrier status:<\/strong> screen and consider antiviral prophylaxis &mdash; reactivation risk.<\/li>\n<li><strong>\u00c9l\u0151 olt\u00f3anyagok:<\/strong> Ellenjavallt.<\/li>\n<li><strong>Severe lymphopenia \/ CD4 &lt; 200:<\/strong> continue PCP prophylaxis until lymphocyte recovery.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Gy\u00f3gyszerk\u00f6lcs\u00f6nhat\u00e1sok<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;\">Kombin\u00e1lhat\u00f3<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Hat\u00e1s<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Teend\u0151k<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u00c9l\u0151 olt\u00f3anyagok<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Sz\u00e9lesk\u00f6r\u0171 fert\u0151z\u00e9s<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Ellenjavallt.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Egy\u00e9b myelosuppressz\u00edv szerek<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Addit\u00edv csontvel\u0151-szupresszi\u00f3<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Szakorvosi fel\u00fcgyelet.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Valproic acid<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Mildly reduces temozolomide clearance<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">No dose adjustment usually needed.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Co-trimoxazole (PCP prophylaxis)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Standard combination<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Continue throughout concurrent phase.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">T\u00e1rol\u00e1s<\/h2>\n<ul>\n<li>Szobah\u0151m\u00e9rs\u00e9kleten, 15\u201330\u00b0C k\u00f6z\u00f6tt, eredeti blistercsomagol\u00e1sban.<\/li>\n<li>Out of reach of children, women of childbearing potential, and pets &mdash; cytotoxic powder.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Kapcsol\u00f3d\u00f3 alternat\u00edv\u00e1k a MedsBase-en<\/h2>\n<p>Tov\u00e1bbi onkol\u00f3giai gy\u00f3gyszerek, amelyek e term\u00e9k mellett el\u00e9rhet\u0151k:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/hu\/endoxan\/\"><strong>Endoxan (ciklofoszfamid 50 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/celkeran\/\"><strong>Celkeran (kl\u00f3rambucil 2 \/ 5 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/temotero\/\"><strong>Temotero (temozolomid 20 \/ 100 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/lomoother\/\"><strong>Lomoother (lomusztin 40 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/endace\/\"><strong>Endace (megesztrol 40 \/ 160 mg)<\/strong><\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/medsbase.com\/hu\/anti-cancer-medication\/\">\u00d6sszes r\u00e1kkel szembeni gy\u00f3gyszer b\u00f6ng\u00e9sz\u00e9se \u2192<\/a><\/p>\n<h2 id=\"faqs\">Gyakran Ism\u00e9telt K\u00e9rd\u00e9sek<\/h2>\n<h3 class=\"wp-block-heading\">What is the Stupp protocol?<\/h3>\n<p>The Stupp protocol (2005) is the standard combined chemoradiotherapy regimen for newly-diagnosed glioblastoma multiforme: <strong>radiotherapy (60 Gy in 30 fractions) + concurrent temozolomide (75 mg\/m&sup2;\/day) for 6 weeks, then 4-week break, then maintenance temozolomide (150&ndash;200 mg\/m&sup2;\/day for days 1&ndash;5 of each 28-day cycle) for 6 cycles<\/strong>. The protocol extended median survival from 12 to 15 months and remains the global standard in 2026.<\/p>\n<h3 class=\"wp-block-heading\">Why must I take Temozol on an empty stomach?<\/h3>\n<p>Food slows temozolomide absorption and reduces peak plasma concentration. For consistent dosing, take temozolomide at the same time each day with no food for at least 2 hours before. Most patients take it at bedtime &ge; 2 hours after the last meal. Take ondansetron 8 mg orally 1 hour before each dose to prevent nausea.<\/p>\n<h3 class=\"wp-block-heading\">Why do I need PCP prophylaxis?<\/h3>\n<p>The continuous 6-week concurrent phase causes prolonged lymphopenia &mdash; particularly low CD4 counts &mdash; that creates a real risk of <strong>Pneumocystis jirovecii pneumonia (PCP)<\/strong>, a potentially fatal opportunistic infection. Standard prophylaxis: <strong>co-trimoxazole 480 mg three times weekly<\/strong> throughout concurrent phase, continued until CD4 recovery (often takes 6+ months).<\/p>\n<h3 class=\"wp-block-heading\">What does &ldquo;MGMT methylation&rdquo; mean for my treatment?<\/h3>\n<p>MGMT (O6-methylguanine-DNA methyltransferase) is a DNA repair enzyme that undoes temozolomide&#39;s alkylation damage. <strong>MGMT-methylated<\/strong> tumours have low MGMT expression &mdash; they cannot repair the damage, so respond much better to temozolomide. <strong>MGMT-unmethylated<\/strong> tumours have high MGMT expression and are relatively temozolomide-resistant. MGMT status is determined on the surgical biopsy and influences treatment intensity (longer maintenance, more aggressive regimens) and prognosis.<\/p>\n<h3 class=\"wp-block-heading\">Milyen v\u00e9rvizsg\u00e1latokra van sz\u00fcks\u00e9gem?<\/h3>\n<p>FBC weekly during the concurrent radiotherapy phase. Before each maintenance cycle: FBC on day 22 of the previous cycle and day 1 of the new cycle. LFTs monthly. Hold cycle for ANC &lt; 1,500\/&micro;L or platelets &lt; 100,000\/&micro;L &mdash; thrombocytopenia is the dose-limiting toxicity.<\/p>\n<h3 class=\"wp-block-heading\">What if I vomit a dose?<\/h3>\n<p>If you vomit within 1 hour of taking Temozol, do NOT re-dose &mdash; the safety risk of double-dosing is greater than the modest loss of efficacy from one missed dose. Resume the next dose at the scheduled time. Speak to your oncology team about pre-medication adjustment if vomiting recurs.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol on Temozol?<\/h3>\n<p>Avoid during active treatment. Both alcohol and temozolomide are hepatotoxic, and alcohol increases nausea. Even after treatment finishes, limit alcohol given the hepatic and bone marrow recovery period.<\/p>\n<h3 class=\"wp-block-heading\">Will Temozol cure my brain tumour?<\/h3>\n<p>Glioblastoma multiforme remains one of the most aggressive cancers. The Stupp protocol is the established standard and improves median survival, but cure is uncommon at present. Specific situations carry better prognosis: younger age, MGMT methylation, complete surgical resection, IDH mutation. Discuss prognosis honestly with your neuro-oncologist &mdash; treatment goals depend on individual disease characteristics.<\/p>\n<p><!-- medsbase-why-order --><\/p>\n<h3>Mi\u00e9rt rendelj a MedsBase-r\u00f3l<\/h3>\n<p>Minden t\u00e9tel egy <strong>WHO-GMP tan\u00fas\u00edtott gy\u00e1rt\u00f3<\/strong>. WHO-GMP <a href=\"\/hu\/medsbase-re-shipment-assurance-policy\/\">\u00dajrak\u00fcld\u00e9si Garancia<\/a>: ha egy csomag nem \u00e9rkezik meg 20 munkanapon bel\u00fcl, ingyenes ut\u00e1nk\u00fcld\u00e9st biztos\u00edtunk, k\u00e9rd\u00e9sek n\u00e9lk\u00fcl.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Kapcsol\u00f3d\u00f3 r\u00e1kellenes gy\u00f3gyszerek<\/h3>\n<p>Tov\u00e1bbi onkol\u00f3giai gy\u00f3gyszerek, amelyek e term\u00e9k mellett el\u00e9rhet\u0151k:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/hu\/temotero\/\">Temotero (temozolomid 100\/250 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/lomoother\/\">Lomoother (lomusztin 40 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/endoxan\/\">Endoxan (ciklofoszfamid 50 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/hydrosar\/\">Hydrosar (hidroxiurea 500 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/hu\/folitrax\/\">Folitrax (metotrex\u00e1t 2,5\/7,5\/10 mg)<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Shrinks brain tumors<br \/>\n\u2705 Delays tumor growth<br \/>\n\u2705 N\u00f6veli a t\u00fal\u00e9l\u00e9si ar\u00e1nyt<br \/>\n\u2705 Jav\u00edtja az \u00e9letmin\u0151s\u00e9get<br \/>\n\u2705 Reduces cancer symptoms<\/p>\n<p>Temozol contains Temozolomide.<\/p>","protected":false},"featured_media":60750,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[4914,4915],"class_list":{"0":"post-60749","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-temozol","10":"product_tag-temozolomide","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product\/60749","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/comments?post=60749"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/media\/60750"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/media?parent=60749"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product_brand?post=60749"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product_cat?post=60749"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/hu\/wp-json\/wp\/v2\/product_tag?post=60749"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}