{"id":61116,"date":"2024-02-28T07:25:37","date_gmt":"2024-02-28T07:25:37","guid":{"rendered":"https:\/\/medsname.com\/champix\/"},"modified":"2026-05-01T10:49:16","modified_gmt":"2026-05-01T10:49:16","slug":"champix","status":"publish","type":"product","link":"https:\/\/medsbase.com\/hu\/product\/champix\/","title":{"rendered":"Champix"},"content":{"rendered":"

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⚡ Quick Answer — Champix — varenicline 1 mg for smoking cessation<\/h3>\n

Champix is varenicline 1 mg, an α4β2 nicotinic-acetylcholine partial agonist that reduces nicotine cravings and the rewarding effect of smoking. Set a quit date 8–14 days into a 12-week course; titrate from 0.5 mg once daily up to 1 mg twice daily. Most effective when combined with behavioural support; the 2016 EAGLES trial removed the historical neuropsychiatric black-box.<\/p>\n<\/div>\n

\nMit kapsz a MedsBase-n\u00e1l:<\/strong> WHO-GMP min\u0151s\u00edt\u00e9s\u0171 gy\u00e1rt\u00f3 \u00b7 Diszkr\u00e9t csomagol\u00e1s \u00b7 Vil\u00e1gszerte sz\u00e1ll\u00edt\u00e1s \u00b7 1.400+ hiteles\u00edtett v\u00e1s\u00e1rl\u00f3i v\u00e9lem\u00e9ny<\/a>\n<\/div>\n

\ud83d\udce6 Minden rendel\u00e9st fedez a \u00dajrak\u00fcld\u00e9si Garancia<\/strong><\/a> \u2014 ha a csomagod nem \u00e9rkezik meg 20 munkanapon bel\u00fcl, \u00fajrak\u00fcldj\u00fck.<\/p>\n

Mi\u00e9rt rendelj a MedsBase-r\u00f3l<\/h3>\n

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What is Champix?<\/h2>\n

Champix is a smoking-cessation aid containing varenicline 1 mg<\/strong> (film-coated tablets), supplied by Pfizer. It is a selective partial agonist at the α4β2 subtype of the neuronal nicotinic acetylcholine receptor — the same receptor nicotine binds — and is one of the most effective monotherapies for tobacco dependence, with cessation rates roughly two to three times those of placebo and consistently superior to single-agent nicotine-replacement therapy in head-to-head trials.<\/p>\n

How varenicline works<\/h2>\n

Varenicline binds the α4β2 nicotinic receptor with both agonist and antagonist<\/strong> properties: as a partial agonist it produces about 30–60% of nicotine’s dopamine release, dampening cravings and withdrawal; as an antagonist it occupies the receptor and blocks the dopaminergic surge from any cigarette smoked while on therapy, so a cigarette during the course feels much less rewarding than usual. This dual action distinguishes it from bupropion (an atypical antidepressant with weak nicotinic antagonism) and from nicotine-replacement therapy (full agonism only).<\/p>\n

How Champix is used<\/h2>\n

The standard adult course is 12 h\u00e9t<\/strong>. Set a quit date 8–14 days into the course — do not stop smoking on day 1. An alternative “flexible quit” approach lets the smoker reduce gradually over the first 12 weeks and quit any time before the end.<\/p>\n\n\n\n\n\n\n\n\n
Days<\/th>\nDose<\/th>\nMegjegyz\u00e9sek<\/th>\n<\/tr>\n<\/thead>\n
1\u20133. nap<\/td>\n0.5 mg once daily<\/td>\nAfter breakfast<\/td>\n<\/tr>\n
Days 4–7<\/td>\n0.5 mg twice daily<\/td>\n12 hours apart<\/td>\n<\/tr>\n
Day 8 onwards (week 2–12)<\/td>\n1 mg twice daily<\/strong><\/td>\nMaintenance; quit date in this window<\/td>\n<\/tr>\n
Optional 12-week extension<\/td>\n1 mg twice daily<\/td>\nFor those who quit successfully — doubles 1-year abstinence rates<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Take with a full glass of water after a meal<\/strong> — nausea is the most common reason for discontinuation and is reduced by food and adequate hydration. If 1 mg twice daily is not tolerated, dropping back to 0.5 mg twice daily is acceptable and still active.<\/p>\n

Vese-funkci\u00f3hoz igaz\u00edtott adagol\u00e1s<\/h2>\n

Varenicline is excreted ~92% unchanged in urine. Dose adjustment is required in significant renal impairment:<\/p>\n\n\n\n\n\n\n\n
eGFR (mL\/perc\/1,73 m\u00b2)<\/th>\nMaxim\u00e1lis adag<\/th>\n<\/tr>\n<\/thead>\n
≥ 30 (mild–moderate impairment)<\/td>\nStandard 1 mg BID<\/td>\n<\/tr>\n
< 30 (severe impairment)<\/td>\n1 mg once daily (titrate from 0.5 mg daily)<\/td>\n<\/tr>\n
Hemodial\u00edzis<\/td>\n0.5 mg once daily, may titrate to 1 mg once daily<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
Neuropsychiatric history.<\/strong> The original FDA black-box warning (2009) was removed in 2016<\/strong> after the EAGLES trial (8,144 randomised smokers, including a stable-psychiatric cohort) found no statistically significant excess of clinically significant neuropsychiatric events versus placebo, NRT, or bupropion. However, smoking cessation itself can unmask underlying mood symptoms; patients with serious mental illness should still be monitored for new or worsening depression, anxiety, agitation, or suicidal ideation, especially in the first 4 weeks. Stop and contact a clinician if these emerge.<\/div>\n

Gyakori mell\u00e9khat\u00e1sok<\/h2>\n