{"id":61456,"date":"2024-02-28T07:41:49","date_gmt":"2024-02-28T07:41:49","guid":{"rendered":"https:\/\/medsname.com\/d-mine\/"},"modified":"2026-05-01T10:49:16","modified_gmt":"2026-05-01T10:49:16","slug":"d-mine","status":"publish","type":"product","link":"https:\/\/medsbase.com\/hu\/product\/d-mine\/","title":{"rendered":"D-mine"},"content":{"rendered":"

<\/p>\n

\n

⚡ Quick Answer — What is D-mine?<\/h3>\n
\n

D-mine<\/strong> tartalmaz imipramine 25 mg<\/strong> from a WHO-GMP certified manufacturer (Sun Pharma) — the original tricyclic antidepressant<\/strong>, in continuous clinical use since 1959. Tertiary-amine TCA: serotonin and norepinephrine reuptake inhibition plus muscarinic, histamine H1<\/sub>, and alpha-1 antagonism (the source of side effects). Largely displaced by SSRIs for first-line depression but still used for: p\u00e1nikbetegs\u00e9g<\/strong> (one of the most-evidenced TCAs for this), chronic neuropathic pain<\/strong> at low doses, and paediatric nocturnal enuresis<\/strong> (bedwetting) where it has FDA approval. Cardiac toxicity in overdose<\/strong> — baseline ECG before starting. Strong anticholinergic burden — not first-line in older adults.<\/p>\n<\/div>\n

\nMit kapsz a MedsBase-n\u00e1l:<\/strong> WHO-GMP min\u0151s\u00edt\u00e9s\u0171 gy\u00e1rt\u00f3 \u00b7 Diszkr\u00e9t csomagol\u00e1s \u00b7 Vil\u00e1gszerte sz\u00e1ll\u00edt\u00e1s \u00b7 1.400+ hiteles\u00edtett v\u00e1s\u00e1rl\u00f3i v\u00e9lem\u00e9ny<\/a>\n<\/div>\n

\ud83d\udce6 Minden rendel\u00e9st fedez a \u00dajrak\u00fcld\u00e9si Garancia<\/strong><\/a> \u2014 ha a csomagod nem \u00e9rkezik meg 20 munkanapon bel\u00fcl, \u00fajrak\u00fcldj\u00fck.<\/p>\n

Mi\u00e9rt rendelj a MedsBase-r\u00f3l<\/h3>\n

Generikus gy\u00f3gyszereink WHO-GMP min\u0151s\u00edt\u00e9s\u0171 gy\u00e1rt\u00f3kt\u00f3l sz\u00e1rmaznak, \u00e9s diszkr\u00e9t, egyszer\u0171 csomagol\u00e1sban sz\u00e1ll\u00edtjuk \u0151ket vil\u00e1gszerte \u2014 a csomagon nem szerepel a gy\u00f3gyszer neve. A k\u00e1rty\u00e1s fizet\u00e9sek egy szab\u00e1lyozott feldolgoz\u00f3n kereszt\u00fcl t\u00f6rt\u00e9nnek (a sz\u00e1mlale\u00edr\u00e1sok egy szab\u00e1lyozott k\u00e1rtyafizet\u00e9si feldolgoz\u00f3t tartalmaznak \u2014 soha nem \u201cMedsBase\u201d vagy b\u00e1rmilyen gy\u00f3gyszer neve). Kriptovalut\u00e1t \u00e9s SEPA banki \u00e1tutal\u00e1st is elfogadunk. Minden rendel\u00e9st a Reshipment Assurance Policy biztos\u00edt\u00e9k fedez.<\/p>\n<\/div>\n

Fontos \u2014 ez nem helyzeti szorong\u00e1sra sz\u00e1nt gy\u00f3gyszer.<\/strong> D-mine is a tricyclic antidepressant (TCA)<\/strong>, hetekig tart\u00f3 fel\u00edr\u00e1ssal \u00e9s adagol\u00e1ssal kezelhet\u0151 major depressive disorder (MDD), panic disorder, paediatric nocturnal enuresis, and chronic pain syndromes<\/strong>. Ez nem<\/strong> , a megfelel\u0151 gy\u00f3gyszer akut, teljes\u00edtm\u00e9nyhez kapcsol\u00f3d\u00f3 szorong\u00e1s eset\u00e9n (rep\u00fcl\u00e9s, nyilv\u00e1nos besz\u00e9d, vizsg\u00e1k) \u2014 ezekre az esetekre klinikailag a b\u00e9ta-blokkol\u00f3k (propranolol), benzodiazepinek vagy hydroxyzine alkalmasak. Ha nincs diagnosztiz\u00e1lt hangulati, szorong\u00e1sos vagy pszichi\u00e1triai zavara, ne kezdje el ezt a gy\u00f3gyszert.<\/div>\n
FDA fekete dobozos figyelmeztet\u00e9s \u2014 \u00f6ngyilkoss\u00e1gi kock\u00e1zat.<\/strong> Az \u00f6sszes antidepressz\u00e1ns hordoz egy FDA fekete dobozos figyelmeztet\u00e9st a gyermekekn\u00e9l, serd\u00fcl\u0151kn\u00e9l \u00e9s 25 \u00e9v alatti fiatal feln\u0151ttekn\u00e9l fokozott \u00f6ngyilkoss\u00e1gi gondolkod\u00e1s \u00e9s viselked\u00e9s kock\u00e1zat\u00e1ra, k\u00fcl\u00f6n\u00f6sen a kezel\u00e9s els\u0151 heteiben vagy adagv\u00e1ltoztat\u00e1sok ut\u00e1n. A csal\u00e1dtagoknak \u00e9s fel\u00edr\u00f3 orvosoknak figyelmesen kell monitorozniuk a rosszabbod\u00f3 hangulatot, izgatotts\u00e1got vagy \u00f6ngyilkos gondolatokat ebben a korcsoportban.<\/div>\n

What Is D-mine?<\/h2>\n

D-mine is an oral tablet of imipramine hydrochloride 25 mg<\/strong> manufactured by Sun Pharma. Imipramine (US brand Tofranil<\/strong>) was synthesised in 1948 and identified as the first effective antidepressant in 1957 — the foundation of modern psychopharmacology. It is a tertiary-amine tricyclic antidepressant<\/strong> that inhibits serotonin and norepinephrine reuptake while also blocking muscarinic, histamine H1<\/sub>, and alpha-1 receptors. The serotonergic \/ noradrenergic actions drive efficacy; receptor blockade drives most of the side-effect burden.<\/p>\n

J\u00f3v\u00e1hagyott indik\u00e1ci\u00f3k<\/h2>\n
    \n
  • Nagy depresszi\u00f3s zavar<\/strong> — second- or third-line after SSRIs \/ SNRIs<\/li>\n
  • P\u00e1nikzavar<\/strong> — one of the most-evidenced TCAs; effective but better tolerated alternatives exist<\/li>\n
  • Childhood nocturnal enuresis (bedwetting)<\/strong> — FDA-approved for ages 6+ when behavioural therapy and desmopressin have failed<\/li>\n
  • Off-label: chronic neuropathic pain, fibromyalgia, post-herpetic neuralgia, chronic low back pain<\/li>\n<\/ul>\n

    Adagol\u00e1s<\/h2>\n\n\n\n\n\n\n\n\n\n
    Agoprex is a 25 mg agomelatine tablet supplied by Sun Pharma. Agomelatine is mechanistically unique among antidepressants: it acts as an agonist at melatonin MT1 and MT2 receptors and an antagonist at 5-HT2C serotonin receptors. The dual mechanism resynchronises disrupted circadian rhythms (a feature of major depression) while indirectly increasing dopamine and noradrenaline release in the frontal cortex.<\/th>\nKezel\u00e9s ind\u00edt\u00e1sa<\/th>\nIndications and dosing<\/th>\nMegjegyz\u00e9sek<\/th>\n<\/tr>\n<\/thead>\n
    MDD (adult outpatient)<\/td>\n25–75 mg\/day at bedtime<\/td>\n100\u2013200 mg\/nap<\/td>\nMaximum 200 mg\/day outpatient; up to 300 mg\/day inpatient; titrate over 2–4 weeks<\/td>\n<\/tr>\n
    MDD (elderly)<\/td>\n10–25 mg at bedtime<\/td>\n25–100 mg\/day<\/td>\nLower target; greater anticholinergic and orthostatic risk<\/td>\n<\/tr>\n
    P\u00e1nikzavar<\/td>\n10–25 mg at bedtime × 1 week<\/td>\n75–200 mg\/day<\/td>\nLass\u00fa d\u00f3zisemel\u00e9s a korai p\u00e1nikrohamok s\u00falyosbod\u00e1s\u00e1nak elker\u00fcl\u00e9se \u00e9rdek\u00e9ben<\/td>\n<\/tr>\n
    Childhood enuresis (age 6–12)<\/td>\n25 mg one hour before bedtime<\/td>\n25–50 mg one hour before bedtime<\/td>\nMaximum 2.5 mg\/kg\/day; reassess after 3 months — relapse common on stopping<\/td>\n<\/tr>\n
    Childhood enuresis (age 12+)<\/td>\n25 mg one hour before bedtime<\/td>\n25–75 mg one hour before bedtime<\/td>\nMaximum 75 mg\/day; same reassessment<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    Side Effects (Anticholinergic Burden Is the Main Issue)<\/h2>\n

    Mell\u00e9khat\u00e1si profil mechanizmus szerint<\/h2>\n\n\n\n\n\n\n\n\n\n\n
    \u2014 ha 20 munkanapon bel\u00fcl nem \u00e9rkezik meg, ingyenesen \u00fajrak\u00fcldj\u00fck. Ez az egyetlen h\u00e1ny\u00e1sg\u00e1tl\u00f3 kombin\u00e1ci\u00f3, amely FDA A kateg\u00f3ri\u00e1j\u00fa st\u00e1tusszal rendelkezik a terhess\u00e9g alatt, \u00e9s az ACOG, a NICE \u00e9s a SOGC els\u0151vonalbeli aj\u00e1nl\u00e1sa a terhess\u00e9gi h\u00e1nyinger \u00e9s h\u00e1ny\u00e1s kezel\u00e9s\u00e9re.<\/th>\nH\u00e1nyinger, hasi f\u00e1jdalom, fejf\u00e1j\u00e1s, sz\u00e9d\u00fcl\u00e9s, gynekomastia (f\u00e9rfiakn\u00e1l, d\u00f3zisf\u00fcgg\u0151)<\/th>\nMegjegyz\u00e9sek<\/th>\n<\/tr>\n<\/thead>\n
    Anticholinergic (muscarinic blockade)<\/td>\nDry mouth, constipation, urinary retention, blurred vision, cognitive impairment<\/td>\nHeavy — not first-line in older adults; caution with BPH, glaucoma, dementia<\/td>\n<\/tr>\n
    H1<\/sub> blok\u00e1d<\/td>\nSedation, weight gain<\/td>\nUseful when insomnia is part of the depression; less useful daytime<\/td>\n<\/tr>\n
    Alfa-1 blok\u00e1d<\/td>\nOrthostatic hypotension, dizziness, falls<\/td>\nParticularly problematic in older adults; check lying \/ standing BP<\/td>\n<\/tr>\n
    Cardiac (sodium-channel blockade)<\/td>\nQT and QRS prolongation, AV block<\/td>\nBaseline ECG before starting in patients > 50 or with cardiac history; deadly in overdose — do not provide bulk supplies to acute suicide-risk patients<\/td>\n<\/tr>\n
    Serotonergic \/ noradrenergic<\/td>\nSweating, tremor, sexual dysfunction<\/td>\nGenerally manageable<\/td>\n<\/tr>\n
    Egy\u00e9b<\/td>\nLowered seizure threshold, paradoxical mania (in unrecognised bipolar)<\/td>\nCaution in epilepsy, screen for bipolar before starting<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    Gy\u00f3gyszerk\u00f6lcs\u00f6nhat\u00e1sok<\/h2>\n

    Abszol\u00fat kontraindik\u00e1ci\u00f3k<\/strong>: MAOIs (14-day washout), recent myocardial infarction, severe uncontrolled cardiac disease.<\/p>\n

    Sz\u00edvriziko<\/strong>: avoid concurrent QT-prolonging drugs (citalopram > 20 mg, quetiapine, ziprasidone, ondansetron, methadone, fluoroquinolones).<\/p>\n

    CYP2D6 szubsztr\u00e1t<\/strong>: plasma levels rise with strong inhibitors (paroxetine, fluoxetine, bupropion, quinidine). Use lower doses.<\/p>\n

    Anticholinergic potentiation<\/strong>: combine cautiously with other anticholinergics (diphenhydramine, scopolamine, trihexyphenidyl, oxybutynin).<\/p>\n

    Sedation \/ orthostasis<\/strong>: alcohol, benzodiazepines, opioids, alpha-blockers.<\/p>\n

    Cardiac Safety and Overdose Risk<\/h2>\n

    TCAs are among the most lethal drugs in overdose<\/strong> because of cardiac sodium-channel blockade, which produces wide-complex tachycardia, ventricular arrhythmias, and cardiogenic shock at doses 5–10x therapeutic. Alapvonalas EKG<\/strong> is standard practice before starting in patients over 50 or with cardiac risk factors. Provide only 1–2 weeks of medication at a time<\/strong> to patients at meaningful suicide risk — a 30-day supply of imipramine 25 mg is potentially lethal.<\/p>\n

    Gyakran Ism\u00e9telt K\u00e9rd\u00e9sek<\/h2>\n

    How long does D-mine take to work?<\/h3>\n

    Mood response in MDD typically appears at 4–6 weeks. Panic disorder response at 4–8 weeks. Enuresis response in children is usually seen within 1–2 weeks of an effective dose.<\/p>\n

    Is D-mine safer than amitriptyline?<\/h3>\n

    Imipramine and amitriptyline have similar profiles. Nortriptyline (Primox on this site) and desipramine (secondary-amine TCAs) are usually better tolerated — less anticholinergic and less sedating — if a tricyclic is needed.<\/p>\n

    Can children safely take D-mine for bedwetting?<\/h3>\n

    Yes — imipramine has been used for paediatric nocturnal enuresis since the 1960s with FDA approval. Always third-line after behavioural \/ alarm therapy and desmopressin. Cardiac risk is low at standard enuresis doses but ECG should be checked if dose exceeds 75 mg\/day or if there is a family history of arrhythmia \/ sudden death.<\/p>\n

    Why are TCAs no longer first-line for depression?<\/h3>\n

    Side-effect burden (anticholinergic, sedation, orthostasis) and overdose lethality have shifted first-line treatment to SSRIs and SNRIs since the late 1980s. TCAs remain useful for refractory depression, neuropathic pain, and panic.<\/p>\n

    Will D-mine cause weight gain?<\/h3>\n

    Yes — TCAs cause significant weight gain (5–10 kg or more over months) through H1<\/sub> appetite stimulation. This is one of the main reasons patients switch to SSRIs.<\/p>\n

    Can I drink alcohol on D-mine?<\/h3>\n

    Avoid heavy alcohol — additive sedation, orthostasis, and lowered seizure threshold. Light occasional alcohol is generally tolerated but caution is warranted.<\/p>\n

    Mi t\u00f6rt\u00e9nik, ha kihagyok egy adagot?<\/h3>\n

    Take it as soon as you remember unless close to the next dose. Imipramine has a long half-life so missing one dose rarely causes withdrawal.<\/p>\n

    Is D-mine safe in pregnancy?<\/h3>\n

    Limited data — not first-line in pregnancy. SSRIs (sertraline preferred) have a far larger safety database. Late third-trimester exposure has been associated with neonatal withdrawal symptoms.<\/p>\n

    Can D-mine be combined with other antidepressants?<\/h3>\n

    Sometimes — low-dose TCAs are added to SSRIs in treatment-resistant depression but only under prescriber direction. Combining with MAOIs is contraindicated.<\/p>\n

    How should D-mine be stored?<\/h3>\n

    Store at 15–30 °C in the original blister packaging away from moisture and sunlight. Keep strictly out of reach of children<\/strong> — TCA overdose is rapidly lethal.<\/p>\n

    Orvosi felel\u0151ss\u00e9gi nyilatkozat:<\/strong> Az oldalon tal\u00e1lhat\u00f3 inform\u00e1ci\u00f3k feln\u0151ttek sz\u00e1m\u00e1ra k\u00e9sz\u00fcltek, akik pszichi\u00e1triai gy\u00f3gyszereket haszn\u00e1lnak, \u00e9s nem helyettes\u00edtik az egy\u00e9ni orvosi ell\u00e1t\u00e1st. Az antidepressz\u00e1nsok, antipszichotikumok \u00e9s kapcsol\u00f3d\u00f3 gy\u00f3gyszerek k\u00f6lcs\u00f6nhat\u00e1sba l\u00e9phetnek m\u00e1s gy\u00f3gyszerekkel, alkohollal \u00e9s alapbetegs\u00e9gekkel. Minden \u00faj gy\u00f3gyszer, adagv\u00e1ltoztat\u00e1s vagy tervezett elhagy\u00e1s eset\u00e9n konzult\u00e1lj egy k\u00e9pzett fel\u00edr\u00f3 orvossal. Ha \u00f6ngyilkos gondolatok, m\u00e1ni\u00e1s t\u00fcnetek, s\u00falyos akat\u00edzia, szerotonin szindr\u00f3ma jelei (magas l\u00e1z, zavarts\u00e1g, izommerevs\u00e9g, gyors sz\u00edvver\u00e9s) vagy neuroleptikus malignus szindr\u00f3ma l\u00e9p fel, azonnal keress fel v\u00e9szell\u00e1t\u00e1st.<\/div>\n

    <\/p>\n

    Kapcsol\u00f3d\u00f3 alternat\u00edv\u00e1k<\/h3>\n

    Egy\u00e9b term\u00e9kek a Kr\u00f3nikus betegs\u00e9gek<\/strong> v\u00e1s\u00e1rl\u00f3k \u00e1ltal szint\u00e9n megtekintett term\u00e9kek:<\/p>\n