{"id":70664,"date":"2026-05-12T08:56:17","date_gmt":"2026-05-12T08:56:17","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&#038;p=70664"},"modified":"2026-05-21T07:14:10","modified_gmt":"2026-05-21T07:14:10","slug":"mots-c","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ja\/product\/mots-c\/","title":{"rendered":"MOTS-c"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background: #fff8e1; border-left: 4px solid #f5a623; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<h3 style=\"margin: 0 0 8px 0; font-size: 16px; color: #1a4a6b;\">\u30af\u30a4\u30c3\u30af\u30a2\u30f3\u30b5\u30fc \u2014 MOTS-c\u3068\u306f\u4f55\u3067\u3059\u304b\uff1f<\/h3>\n<p style=\"margin: 0;\"><strong>MOTS-c<\/strong> \uff0812S rRNA-c\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30aa\u30fc\u30d7\u30f3\u30ea\u30fc\u30c7\u30a3\u30f3\u30b0\u30d5\u30ec\u30fc\u30e0\uff09\u306f\u30012015\u5e74\u306b\u521d\u3081\u3066\u540c\u5b9a\u3055\u308c\u305f16\u30a2\u30df\u30ce\u9178\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u30b3\u30fc\u30c9\u3055\u308c\u305f\u30b7\u30b0\u30ca\u30eb\u30da\u30d7\u30c1\u30c9\u3067\u3059\u3002\u767a\u8868\u3055\u308c\u305f\u524d\u81e8\u5e8a\u7814\u7a76\u3067\u306f\u3001AMPK\u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3057\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3092\u56de\u5fa9\u3057\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30b9\u30c8\u30ec\u30b9\u306b\u5fdc\u7b54\u3057\u3066\u6838\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u904b\u52d5\u6a21\u5023\u4f5c\u7528\u3068\u4ee3\u8b1d\u8abf\u7bc0\u56e0\u5b50\u3068\u3057\u3066\u6a5f\u80fd\u3057\u307e\u3059\u3002\u5b9f\u9a13\u5ba4\u7814\u7a76\u7528\u306b10mg\uff5e40mg\u306e\u51cd\u7d50\u4e7e\u71e5\u30d0\u30a4\u30a2\u30eb\u3067\u4f9b\u7d66\u3055\u308c\u307e\u3059\u3002<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background: #f4f8fb; border: 1px solid #d8e3eb; padding: 12px 16px; margin: 16px 0; border-radius: 4px; font-size: 14px;\"><strong>MedsBase\u3067\u5f97\u3089\u308c\u308b\u3082\u306e\uff1a<\/strong> \u7814\u7a76\u30b0\u30ec\u30fc\u30c9\u306e\u51cd\u7d50\u4e7e\u71e5\u30da\u30d7\u30c1\u30c9 \u00b7 HPLC\u7d14\u5ea699%\u4ee5\u4e0a\uff08COA\u306f\u3054\u8981\u671b\u306b\u5fdc\u3058\u3066\uff09 \u00b7 \u4e2d\u8eab\u304c\u308f\u304b\u3089\u306a\u3044\u6e29\u5ea6\u5b89\u5b9a\u6027\u5305\u88c5 \u00b7 \u30da\u30d7\u30c1\u30c9\u306e\u5168\u4e16\u754c\u914d\u9001 \u00b7 1,400\u4ef6\u4ee5\u4e0a\u306e\u691c\u8a3c\u6e08\u307f <a href=\"https:\/\/medsbase.com\/ja\/reviews\/\">\u30ab\u30b9\u30bf\u30de\u30fc\u30ec\u30d3\u30e5\u30fc<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size: 14px; color: #444; margin: 8px 0 18px;\">\ud83d\udce6 \u3059\u3079\u3066\u306e\u3054\u6ce8\u6587\u306f\u3001\u5f53\u5e97\u306e <a href=\"https:\/\/medsbase.com\/ja\/medsbase-re-shipment-assurance-policy\/\"><strong>\u518d\u767a\u9001\u4fdd\u8a3c\u30dd\u30ea\u30b7\u30fc<\/strong><\/a> \u2014 \u4e07\u304c\u4e00\u300120\u55b6\u696d\u65e5\u4ee5\u5185\u306b\u5546\u54c1\u304c\u5c4a\u304b\u306a\u3044\u5834\u5408\u306f\u3001\u518d\u767a\u9001\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n<table class=\"medsbase-spec-table\" style=\"width: 100%; border-collapse: collapse; margin: 18px 0; font-size: 14px;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 8px 12px; text-align: left; width: 30%;\">\u4ed5\u69d8<\/th>\n<th style=\"padding: 8px 12px; text-align: left;\">\u8a73\u7d30<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>CAS\u756a\u53f7<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">1627580-64-6<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u5206\u5b50\u5f0f<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">C<sub>100<\/sub>H<sub>152<\/sub>N<sub>28<\/sub>O<sub>22<\/sub>S<sub>2<\/sub><\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u5206\u5b50\u91cf<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">2174.62 Da<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u914d\u5217<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR\u300116\u30a2\u30df\u30ce\u9178\uff1b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a212S rRNA\u907a\u4f1d\u5b50\u306b\u30b3\u30fc\u30c9\u3055\u308c\u3066\u3044\u308b)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u5f62\u614b<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u51cd\u7d50\u4e7e\u71e5\u7c89\u672b\uff08\u767d\u8272\u301c\u5fae\u9ec4\u8272\uff09<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u7d14\u5ea6<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u226599%\uff08HPLC\u691c\u8a3c\u6e08\u307f\u3001COA\u306f\u3054\u8981\u671b\u306b\u5fdc\u3058\u3066\u63d0\u4f9b\uff09<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u4fdd\u7ba1\u65b9\u6cd5<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u51cd\u7d50\u4e7e\u71e5\u54c1\uff1a\u4f7f\u7528\u6642\u5728\u5eab\u306f2\uff5e8\u2103\uff08\u51b7\u8535\uff09\u306b\u4fdd\u7ba1\u3002\u672a\u958b\u5c01\u30d0\u30a4\u30a2\u30eb\u306e\u9577\u671f\u4fdd\u7ba1\u306b\u306f\u221220\u2103\u3002\u518d\u6eb6\u89e3\u5f8c\uff1a2\uff5e8\u2103\u3067\u7d0430\u65e5\u4ee5\u5185\u306b\u4f7f\u7528\u3002\u5149\u304b\u3089\u4fdd\u8b77\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u518d\u6eb6\u89e3\u6db2\u306e\u51cd\u7d50\u878d\u89e3\u306f\u907f\u3051\u3066\u304f\u3060\u3055\u3044\u3002<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u6eb6\u89e3\u6027<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u9759\u83cc\u6c34\uff08\u63a8\u5968\uff09\u307e\u305f\u306f\u77ed\u6642\u9593\u4f7f\u7528\u306e\u5834\u5408\u306f\u6ec5\u83cc\u6c34<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u7814\u7a76\u7528\u9014<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u5b9f\u9a13\u5ba4\u7814\u7a76\u7528\u306e\u307f\u3067\u3059\u3002\u30d2\u30c8\u307e\u305f\u306f\u52d5\u7269\u306e\u8a3a\u65ad\u30fb\u6cbb\u7642\u76ee\u7684\u306b\u306f\u4f7f\u7528\u3057\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><!-- \/medsbase-tldr-answer --><\/p>\n<h2>MOTS-c\u3068\u306f\u4f55\u3067\u3059\u304b\uff1f<\/h2>\n<p><strong>MOTS-c<\/strong> \uff0812S rRNA-c\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30aa\u30fc\u30d7\u30f3\u30ea\u30fc\u30c7\u30a3\u30f3\u30b0\u30d5\u30ec\u30fc\u30e0\uff09\u306f\u3001Lee\u3089\u306b\u3088\u3063\u3066\u6700\u521d\u306b\u540c\u5b9a\u3055\u308c\u305f16\u30a2\u30df\u30ce\u9178\u306e\u30da\u30d7\u30c1\u30c9\u3067\u3001 <em>Cell Metabolism<\/em> \uff082015\u5e74\uff09\u306b\u3001\u65b0\u305f\u306b\u8a8d\u8b58\u3055\u308c\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u7531\u6765\u30da\u30d7\u30c1\u30c9\uff08MDP\uff09\u306e\u4e00\u7a2e\u3068\u3057\u3066\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002\u7814\u7a76\u30ab\u30bf\u30ed\u30b0\u5185\u306e\u4ed6\u306e\u3059\u3079\u3066\u306e\u30da\u30d7\u30c1\u30c9\uff08\u3053\u308c\u3089\u306f\u6838DNA\u306b\u30b3\u30fc\u30c9\u3055\u308c\u7d30\u80de\u8cea\u3067\u5408\u6210\u3055\u308c\u307e\u3059\uff09\u3068\u306f\u7570\u306a\u308a\u3001MOTS-c\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a212S rRNA\u907a\u4f1d\u5b50\u5185\u306b\u30b3\u30fc\u30c9\u3055\u308c\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30ea\u30dc\u30bd\u30fc\u30e0\u306b\u3088\u3063\u3066\u7ffb\u8a33\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u7279\u7570\u306a\u751f\u7269\u5b66\u7684\u8d77\u6e90\u306b\u3088\u308a\u3001MOTS-c\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u72b6\u614b\u306e\u76f4\u63a5\u7684\u306a\u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30eb\u3068\u306a\u308a\u3001\u30d2\u30e5\u30fc\u30de\u30cb\u30f3\u3084SHLP\u30d5\u30a1\u30df\u30ea\u30fc\u3092\u542b\u3080\u30da\u30d7\u30c1\u30c9\u30af\u30e9\u30b9\u306e\u4e2d\u3067\u6700\u3082\u5f15\u7528\u3055\u308c\u308b\u30e1\u30f3\u30d0\u30fc\u3067\u3059\u3002<\/p>\n<p>\u30da\u30d7\u30c1\u30c9\u914d\u5217\u306fMRWQEMGYIFYPRKLR\u3001\u5206\u5b50\u91cf\u7d042,175 Da\u3001\u5b9f\u9a13\u5f0fC<sub>100<\/sub>H<sub>152<\/sub>N<sub>28<\/sub>O<sub>22<\/sub>S<sub>2<\/sub>. \u5185\u56e0\u6027MOTS-c\u306f\u4ee3\u8b1d\u30b9\u30c8\u30ec\u30b9\u3084\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u4e0b\u3067\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304b\u3089\u6838\u3078\u79fb\u884c\u3057\u3001\u8449\u9178\u56de\u8def\/\u30e1\u30c1\u30aa\u30cb\u30f3\u4ee3\u8b1d\u907a\u4f1d\u5b50\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u8abf\u7bc0\u3057\u307e\u3059\u3002\u3053\u308c\u306f\u6838\u30b3\u30fc\u30c9\u30da\u30d7\u30c1\u30c9\u306b\u306f\u985e\u3092\u898b\u306a\u3044\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u3059\u3002MOTS-c\u306f\u9ad8\u7d14\u5ea6\u306e\u51cd\u7d50\u4e7e\u71e5\u7c89\u672b\u3068\u3057\u3066\u4f9b\u7d66\u3055\u308c\u3001\u9759\u83cc\u6c34\u3067\u518d\u6eb6\u89e3\u3057\u3066\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002\u305d\u3057\u3066\u3001 <strong>\u7814\u7a76\u5ba4\u7814\u7a76\u7528\u306e\u307f\u3067\u3059<\/strong>. FDA\u3001EMA\u3001MHRA\u306b\u3088\u308a\u30d2\u30c8\u307e\u305f\u306f\u52d5\u7269\u7528\u306e\u6cbb\u7642\u7528\u9014\u3068\u3057\u3066\u627f\u8a8d\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u95a2\u9023\u3059\u308b\u4ee3\u8b1d\u304a\u3088\u3073\u9577\u5bff\u30da\u30d7\u30c1\u30c9\u306b\u3064\u3044\u3066\u306f\u3001\u5f53\u793e\u306e\u5168 <a href=\"https:\/\/medsbase.com\/ja\/peptides\/\">\u7814\u7a76\u7528\u30da\u30d7\u30c1\u30c9\u30ab\u30bf\u30ed\u30b0<\/a>.<\/p>\n<h2>\u4f5c\u7528\u6a5f\u5e8f \u2014 AMPK\u3001\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u3001\u304a\u3088\u3073\u6838\u79fb\u884c<\/h2>\n<p>MOTS-c\u3092\u5f93\u6765\u306e\u4ee3\u8b1d\u30da\u30d7\u30c1\u30c9\u3068\u5dee\u5225\u5316\u3059\u308b\u306e\u306f\u3001\u305d\u306e <strong>3\u3064\u306e\u4f5c\u7528\u6a5f\u5e8f<\/strong> \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3001\u7d30\u80de\u8cea\u3001\u6838\u306b\u307e\u305f\u304c\u308a\u3001\u305d\u308c\u305e\u308c\u304c\u767a\u8868\u3055\u308c\u305f\u7814\u7a76\u3067\u89b3\u5bdf\u3055\u308c\u305f\u4ee3\u8b1d\u8868\u73fe\u578b\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u307e\u3059\uff1a<\/p>\n<ul>\n<li><strong>AMPK\u7d4c\u8def\u306e\u6d3b\u6027\u5316<\/strong> \u2014 MOTS-c\u306f\u3001\u7d30\u80de\u5185AMP:ATP\u6bd4\u306e\u4e0a\u6607\u3068\u8449\u9178\u56de\u8def\u4f9d\u5b58\u6027\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u901a\u3058\u3066\u3001\u7d30\u80de\u306e\u4e3b\u8981\u306a\u30a8\u30cd\u30eb\u30ae\u30fc\u30bb\u30f3\u30b5\u30fc\u3067\u3042\u308bAMP\u6d3b\u6027\u5316\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\uff08AMPK\uff09\u3092\u6d3b\u6027\u5316\u3057\u307e\u3059\u3002AMPK\u306e\u6d3b\u6027\u5316\u306f\u7d30\u80de\u4ee3\u8b1d\u3092\u7570\u5316\u65b9\u5411\u3078\u30b7\u30d5\u30c8\u3055\u305b\u307e\u3059\uff1aGLUT4\u30c8\u30e9\u30f3\u30b9\u30ed\u30b1\u30fc\u30b7\u30e7\u30f3\u3092\u4ecb\u3057\u305f\u30b0\u30eb\u30b3\u30fc\u30b9\u53d6\u308a\u8fbc\u307f\u306e\u5897\u52a0\u3001\u8102\u80aa\u9178\u9178\u5316\u3001PGC-1\u03b1\u3092\u4ecb\u3057\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u751f\u5408\u6210\u3001\u305d\u3057\u3066\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3067\u3059\u3002\u3053\u308c\u306f\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u3084\u904b\u52d5\u304c\u6a19\u7684\u3068\u3059\u308b\u306e\u3068\u540c\u3058\u7d4c\u8def\u3067\u3042\u308a\u3001\u767a\u8868\u3055\u308c\u305f\u6587\u732e\u3067MOTS-c\u304c\u300c\u904b\u52d5\u6a21\u5023\u30da\u30d7\u30c1\u30c9\u300d\u3068\u79f0\u3055\u308c\u308b\u6240\u4ee5\u3067\u3059\u3002<\/li>\n<li><strong>\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3068\u30b0\u30eb\u30b3\u30fc\u30b9\u51e6\u7406<\/strong> \u2014 \u9ad8\u8102\u80aa\u98df\u3092\u4e0e\u3048\u305f\u3052\u3063\u6b6f\u985e\u30e2\u30c7\u30eb\u3067\u306f\u3001MOTS-c\u6295\u4e0e\u306b\u3088\u308a\u9aa8\u683c\u7b4b\u304a\u3088\u3073\u8102\u80aa\u7d44\u7e54\u306b\u304a\u3051\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u523a\u6fc0\u306b\u3088\u308b\u30b0\u30eb\u30b3\u30fc\u30b9\u53d6\u308a\u8fbc\u307f\u304c\u56de\u5fa9\u3057\u307e\u3059\u3002\u4e00\u90e8\u306e\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\u3067\u306f\u3001\u3053\u306e\u52b9\u679c\u306f\u4f53\u91cd\u5909\u5316\u3068\u306f\u7121\u95a2\u4fc2\u3067\u3042\u308a\u3001\u4f53\u91cd\u6e1b\u5c11\u306b\u4f34\u3046\u4e8c\u6b21\u7684\u306a\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u76f4\u63a5\u7684\u306a\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u6539\u5584\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002MOTS-c\u3067\u6cbb\u7642\u3057\u305f\u80a5\u6e80\u30de\u30a6\u30b9\u3067\u306f\u3001\u767a\u8868\u3055\u308c\u305f\u7814\u7a76\u306b\u304a\u3044\u3066\u7d4c\u53e3\u30d6\u30c9\u30a6\u7cd6\u8ca0\u8377\u8a66\u9a13\u306e\u6b63\u5e38\u5316\u3068\u6b63\u5e38\u8840\u7cd6\u30af\u30e9\u30f3\u30d7\u30d1\u30e9\u30e1\u30fc\u30bf\u306e\u6539\u5584\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<li><strong>\u6838\u79fb\u884c\u3068\u9069\u5fdc\u7684\u907a\u4f1d\u5b50\u767a\u73fe<\/strong> \u2014 \u4ee3\u8b1d\u30b9\u30c8\u30ec\u30b9\u3084\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u4e0b\u3067\u306f\u3001MOTS-c\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304b\u3089\u6838\u3078\u79fb\u884c\u3057\u3001\u6297\u9178\u5316\u5fdc\u7b54\uff08NRF2\uff09\u3001\u8449\u9178-\u30e1\u30c1\u30aa\u30cb\u30f3\u56de\u8def\u3001\u304a\u3088\u3073\u9069\u5fdc\u7684\u4ee3\u8b1d\u907a\u4f1d\u5b50\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u8ee2\u5199\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u5171\u8abf\u7bc0\u3057\u307e\u3059\u3002\u3053\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304b\u3089\u6838\u3078\u306e\u9006\u884c\u6027\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306f\u3001\u7d30\u80de\u5185\u533a\u753b\u9593\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u306e\u30da\u30d7\u30c1\u30c9\u30ec\u30d9\u30eb\u3067\u306e\u6700\u521d\u306e\u4f8b\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u76f4\u63a5\u7684\u306aAMPK\u6d3b\u6027\u5316\u3092\u8d85\u3048\u305fMOTS-c\u306e\u5e83\u7bc4\u306a\u52b9\u679c\u306e\u57fa\u76e4\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n<p>\u4ee3\u8b1d\u7814\u7a76\u306b\u304a\u3051\u308bMOTS-c\u306e\u751f\u7269\u5b66\u7684\u9b45\u529b\u306f\u3001\u3053\u308c\u30893\u3064\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u3001\u904b\u52d5\u3084\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u306e\u5229\u70b9\u3092\u5a92\u4ecb\u3059\u308b\u3053\u3068\u304c\u65e2\u306b\u77e5\u3089\u308c\u3066\u3044\u308b\u7d4c\u8def\u306b\u53ce\u675f\u3059\u308b\u70b9\u306b\u3042\u308a\u307e\u3059\u3002\u5185\u56e0\u6027MOTS-c\u306f\u52a0\u9f62\u3068\u3068\u3082\u306b\u30d2\u30c8\u8840\u6e05\u4e2d\u3067\u9855\u8457\u306b\u6e1b\u5c11\u3059\u308b\u305f\u3081\uff08\u767a\u8868\u3055\u308c\u305f\u30b3\u30db\u30fc\u30c8\u3067\u306f\u6210\u4eba\u5bff\u547d\u3092\u901a\u3058\u3066\u7d0450\uff05\u6e1b\u5c11\uff09\u3001\u3053\u306e\u30da\u30d7\u30c1\u30c9\u306f\u8001\u5316\u30fb\u9577\u5bff\u7814\u7a76\u304a\u3088\u3073\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u306b\u304a\u3044\u3066\u983b\u7e41\u306b\u6a19\u7684\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<h2>\u516c\u8868\u3055\u308c\u305f\u7814\u7a76\u7528\u9014<\/h2>\n<p>MOTS-c\u306f\u3001\u4ee5\u4e0b\u3092\u8abf\u67fb\u3059\u308b\u5b9f\u9a13\u5ba4\u7814\u7a76\u3067\u4f7f\u7528\u3055\u308c\u307e\u3059\uff1a<\/p>\n<ul>\n<li><strong>\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u304a\u3088\u3073\u80a5\u6e80\u306b\u95a2\u3059\u308b\u7814\u7a76<\/strong> \u2014 \u9ad8\u8102\u80aa\u98df\u6295\u4e0e\u9f67\u6b6f\u985e\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3001\u8010\u7cd6\u80fd\u3001\u4f53\u7d44\u6210\u8a55\u4fa1\u3002AMPK\u8ef8\u4ecb\u5165\u7814\u7a76\u306e\u30d9\u30f3\u30c1\u30de\u30fc\u30af\u30da\u30d7\u30c1\u30c9\uff08Lee et al., Cell Metabolism 2015; Reynolds et al., Front Physiol 2021\uff09<\/li>\n<li><strong>2\u578b\u7cd6\u5c3f\u75c5\u306e\u524d\u81e8\u5e8a\u30e2\u30c7\u30eb<\/strong> \u2014 db\/db\u3001ZDF\u3001\u304a\u3088\u3073\u30b9\u30c8\u30ec\u30d7\u30c8\u30be\u30c8\u30b7\u30f3\u8a98\u767a\u7cd6\u5c3f\u75c5\u30e2\u30c7\u30eb\uff1b\u809d\u81d3\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3001\u03b2\u7d30\u80de\u6a5f\u80fd\u3001HbA1c\u4ee3\u66ff\u6307\u6a19\u306b\u53ca\u307c\u3059\u5f71\u97ff<\/li>\n<li><strong>\u904b\u52d5\u80fd\u529b\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u751f\u5408\u6210<\/strong> \u2014 \u30c8\u30ec\u30c3\u30c9\u30df\u30eb\u6301\u4e45\u529b\u3001VO<sub>2<\/sub>max\u4ee3\u66ff\u6307\u6a19\u3001PGC-1\u03b1\u767a\u73fe\u3001\u9aa8\u683c\u7b4b\u7814\u7a76\u306b\u304a\u3051\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u30b3\u30d4\u30fc\u6570<\/li>\n<li><strong>\u52a0\u9f62\u3068\u9577\u5bff\u306e\u7814\u7a76<\/strong> \u2014 \u5bff\u547d\u5ef6\u9577\u30e2\u30c7\u30eb\u3001\u52a0\u9f62\u306b\u4f34\u3046\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3001\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\uff1bMOTS-c\u306e\u8840\u6e05\u4e2d\u6fc3\u5ea6\u306f\u52a0\u9f62\u3068\u3068\u3082\u306b\u4f4e\u4e0b\u3057\u3001\u8001\u5e74\u533b\u5b66\u7814\u7a76\u306b\u304a\u3051\u308b\u88dc\u5145\u30da\u30d7\u30c1\u30c9\u306e\u5019\u88dc\u3068\u306a\u3063\u3066\u3044\u308b<\/li>\n<li><strong>\u5fc3\u8840\u7ba1\u304a\u3088\u3073\u814e\u4fdd\u8b77<\/strong> \u2014 \u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u30de\u30fc\u30ab\u30fc\u3001\u5fc3\u81d3\u304a\u3088\u3073\u814e\u7d44\u7e54\u7814\u7a76\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u969c\u5bb3<\/li>\n<li><strong>\u9aa8\u306e\u5065\u5eb7\u7814\u7a76<\/strong> \u2014 \u9aa8\u82bd\u7d30\u80de\u5206\u5316\u3001\u9aa8\u5bc6\u5ea6\u3001\u52a0\u9f62\u6027\u9aa8\u7c97\u9b06\u75c7\u30e2\u30c7\u30eb<\/li>\n<li><strong>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30da\u30d7\u30c1\u30c9\u306e\u6bd4\u8f03\u7814\u7a76<\/strong> \u2014 \u4ed6\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a19\u7684\u30da\u30d7\u30c1\u30c9\u3068\u306e\u30d9\u30f3\u30c1\u30de\u30fc\u30af\uff08\u4f8b\uff1a <a href=\"https:\/\/medsbase.com\/ja\/ss-31-elamipretide\/\">SS-31 (Elamipretide)<\/a>. \u65b9\u6cd5\u8ad6\u7684\u306a\u6bd4\u8f03\u306b\u3064\u3044\u3066\u306f\u4e0b\u8a18\u306e\u6bd4\u8f03\u30bb\u30af\u30b7\u30e7\u30f3\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/li>\n<\/ul>\n<p>MOTS-c\u304c\u4ee3\u8b1d\u304a\u3088\u3073\u9577\u5bff\u30da\u30d7\u30c1\u30c9\u306e\u5168\u4f53\u50cf\u306e\u4e2d\u3067\u3069\u306e\u3088\u3046\u306b\u4f4d\u7f6e\u3065\u3051\u3089\u308c\u308b\u304b\u306b\u3064\u3044\u3066\u3001\u3088\u308a\u5e83\u3044\u6587\u8108\u306b\u3064\u3044\u3066\u306f\u3001 <a href=\"https:\/\/medsbase.com\/ja\/ss-31-elamipretide\/\">SS-31 (Elamipretide)<\/a> \u5178\u578b\u7684\u306a\u30ab\u30eb\u30b8\u30aa\u30ea\u30d4\u30f3\u6a19\u7684\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30da\u30d7\u30c1\u30c9\u3068\u3057\u3066\u3001, <a href=\"https:\/\/medsbase.com\/ja\/epitalon\/\">Epitalon<\/a> \u30c6\u30ed\u30e1\u30a2\uff0f\u9577\u5bff\u7814\u7a76\u7528\u3001\u304a\u3088\u3073 <a href=\"https:\/\/medsbase.com\/ja\/nad\/\">NAD+<\/a> NAD\u8ef8\u306e\u4ee3\u8b1d\u7814\u7a76\u7528\u3002\u5168\u4f53\u3092 <a href=\"https:\/\/medsbase.com\/ja\/peptides\/\">\u7814\u7a76\u7528\u30da\u30d7\u30c1\u30c9\u30ab\u30bf\u30ed\u30b0<\/a> \u5316\u5408\u7269\u9078\u629e\u306e\u305f\u3081\u306b\u3002<\/p>\n<h2>\u5229\u7528\u53ef\u80fd\u306a\u529b\u4fa1\u3068\u6fc3\u5ea6<\/h2>\n<p>MedsBase\u3067\u306f\u3001MOTS-c\u3092\u3001\u4e00\u822c\u7684\u306a\u7814\u7a76\u30d7\u30ed\u30c8\u30b3\u30eb\u671f\u9593\u306b\u5408\u308f\u305b\u305f3\u7a2e\u985e\u306e\u51cd\u7d50\u4e7e\u71e5\u30d0\u30a4\u30a2\u30eb\u30b5\u30a4\u30ba\u3067\u53d6\u308a\u6271\u3063\u3066\u3044\u307e\u3059\u3002\u5404\u7528\u91cf\u306f\u3001\u5b8c\u5168\u306a\u518d\u6eb6\u89e3\u30ac\u30a4\u30c0\u30f3\u30b9\u4ed8\u304d\u306710\u30d0\u30a4\u30a2\u30eb\u5165\u308a\u307e\u305f\u306f20\u30d0\u30a4\u30a2\u30eb\u5165\u308a\u30d1\u30c3\u30af\u5f62\u5f0f\u3067\u3054\u5229\u7528\u3044\u305f\u3060\u3051\u307e\u3059\uff1a<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u30d0\u30a4\u30a2\u30eb\u529b\u4fa1<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u5178\u578b\u7684\u306a\u7814\u7a76\u4f7f\u7528\u4f8b<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u30d1\u30c3\u30af\u30b5\u30a4\u30ba<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>10\u00a0mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u6a19\u6e96\u7684\u306a\u7814\u7a76\u7528\u91cf\u3001\u77ed\u671f\u30b5\u30a4\u30af\u30eb\u30d7\u30ed\u30c8\u30b3\u30eb<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10\u307e\u305f\u306f20\u30d0\u30a4\u30a2\u30eb<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>20\u00a0mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u4e2d\u91cf\u30d0\u30eb\u30af\u30d0\u30a4\u30a2\u30eb\u3001\u7528\u91cf\u3042\u305f\u308a\u306e\u518d\u6eb6\u89e3\u6db2\u91cf\u3092\u4f4e\u6e1b<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10\u307e\u305f\u306f20\u30d0\u30a4\u30a2\u30eb<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>40\u00a0mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u9577\u671f\u30b5\u30a4\u30af\u30eb\u30d7\u30ed\u30c8\u30b3\u30eb\u3001\u9577\u5bff\u7814\u7a76\u30011mg\u3042\u305f\u308a\u306e\u30b3\u30b9\u30c8\u304c\u6700\u3082\u4f4e\u3044<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10\u307e\u305f\u306f20\u30d0\u30a4\u30a2\u30eb<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>3\u3064\u306e\u7528\u91cf\u306f\u3059\u3079\u3066\u540c\u3058\u5316\u5b66\u5f62\u614b\uff08\u51cd\u7d50\u4e7e\u71e5\u7c89\u672b\u3001HPLC\u7d14\u5ea699%\u4ee5\u4e0a\uff09\u3067\u3059\u3002\u9ad8mg\u306e\u30d0\u30a4\u30a2\u30eb\u306f\u3001\u30d0\u30a4\u30a2\u30eb\u3042\u305f\u308a\u306e\u7528\u91cf\u67d4\u8edf\u6027\u304c\u9ad8\u304f\u30011mg\u3042\u305f\u308a\u306e\u30b3\u30b9\u30c8\u304c\u4f4e\u304f\u306a\u308a\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u518d\u6eb6\u89e3\u6db2\u306f30\u65e5\u4ee5\u5185\u306b\u4f7f\u7528\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u305f\u3081\u3001\u8907\u6570\u6708\u306b\u308f\u305f\u308b\u30d7\u30ed\u30c8\u30b3\u30eb\u3067\u306f\u3001\u9031\u3042\u305f\u308a\u306e\u7814\u7a76\u7528\u91cf\u304c\u305d\u308c\u306b\u5fdc\u3058\u3066\u591a\u3044\u5834\u5408\u306b\u9650\u308a\u3001\u3088\u308a\u5927\u304d\u306a\u30d0\u30a4\u30a2\u30eb\u304c\u6709\u5229\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<h2>MOTS-c \u5bfe SS-31\uff08\u30a8\u30e9\u30df\u30d7\u30ec\u30c1\u30c9\uff09\u2014 \u6bd4\u8f03\u30dd\u30a4\u30f3\u30c8<\/h2>\n<p>MOTS-c\u3068 <a href=\"https:\/\/medsbase.com\/ja\/ss-31-elamipretide\/\">SS-31<\/a> \u73fe\u5728\u306e\u7814\u7a76\u3067\u6700\u3082\u591a\u304f\u5f15\u7528\u3055\u308c\u3066\u3044\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a19\u7684\u30da\u30d7\u30c1\u30c9\u306e2\u3064\u3067\u3059\u3002\u3053\u308c\u3089\u306f\u4f5c\u7528\u6a5f\u5e8f\u304c\u7570\u306a\u308a\u3001\u5197\u9577\u3067\u306f\u306a\u304f\u76f8\u88dc\u7684\u3067\u3059\u3002MOTS-c\u306fAMPK\u3068\u6838\u306b\u30b3\u30fc\u30c9\u3055\u308c\u305f\u9069\u5fdc\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u6d3b\u6027\u5316\u3059\u308b\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30da\u30d7\u30c1\u30c9\u3067\u3042\u308a\u3001\u4e00\u65b9\u3001SS-31\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5185\u819c\u306e\u30ab\u30eb\u30b8\u30aa\u30ea\u30d4\u30f3\u306b\u7d50\u5408\u3057\u96fb\u5b50\u4f1d\u9054\u7cfb\u3092\u5b89\u5b9a\u5316\u3059\u308b\u69cb\u9020\u30da\u30d7\u30c1\u30c9\u3067\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u7814\u7a76\u8005\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u4e0d\u5168\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3053\u308c\u3089\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u304c\u3088\u304f\u3042\u308a\u307e\u3059\u3002<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u8a55\u4fa1\u9805\u76ee<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">MOTS-c<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">SS-31 (Elamipretide)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u30a2\u30df\u30ce\u9178\u6570<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">16\u30a2\u30df\u30ce\u9178<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">4\u30a2\u30df\u30ce\u9178\uff08\u30c6\u30c8\u30e9\u30da\u30d7\u30c1\u30c9\uff09<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u7531\u6765<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u306b\u30b3\u30fc\u30c9\u3055\u308c\u308b\uff0812S rRNA\u907a\u4f1d\u5b50\uff09<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u5408\u6210Szeto-Schiller\u30da\u30d7\u30c1\u30c9<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u4e3b\u306a\u4f5c\u7528\u6a5f\u5e8f<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">AMPK\u6d3b\u6027\u5316\u3001\u6838\u5185\u907a\u4f1d\u5b50\u767a\u73fe<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u30ab\u30eb\u30b8\u30aa\u30ea\u30d4\u30f3\u7d50\u5408\u3001ETC\u5b89\u5b9a\u5316<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u7d30\u80de\u6a19\u7684<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2 \u2192 \u7d30\u80de\u8cea \u2192 \u6838<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5185\u819c\u306e\u307f<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u4e00\u822c\u7684\u306a\u7814\u7a76\u7528\u91cf<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">5\uff5e15mg\u3001\u90311\uff5e3\u56de<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">2\uff5e5mg\u3001\u6bce\u65e5<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u6700\u3082\u5f37\u3044\u7814\u7a76\u30b7\u30b0\u30ca\u30eb<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3001\u904b\u52d5\u80fd\u529b\u3001\u8001\u5316<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u5fc3\u865a\u8840\u3001\u814e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u4e0d\u5168<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u30b9\u30bf\u30c3\u30ad\u30f3\u30b0<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u7814\u7a76\u306b\u304a\u3044\u3066SS-31\u3068\u4f75\u7528\u3055\u308c\u308b\u3053\u3068\u304c\u591a\u3044<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">MOTS-c\u3068\u4f75\u7528\u3055\u308c\u308b\u3053\u3068\u304c\u591a\u3044<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>2\u3064\u306e\u30da\u30d7\u30c1\u30c9\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u751f\u7269\u5b66\u306e\u7570\u306a\u308b\u968e\u5c64\u3067\u4f5c\u7528\u3057\u307e\u3059 \u2014 MOTS-c\u306f\u4ee3\u8b1d\u8ee2\u5199\u3092\u8abf\u7bc0\u3057\u3001SS-31\u306f\u819c\u69cb\u9020\u3092\u5b89\u5b9a\u5316\u3055\u305b\u308b\u305f\u3081\u3001\u91cd\u8907\u3057\u306a\u3044\u7814\u7a76\u8ab2\u984c\u306b\u5bfe\u5fdc\u3057\u307e\u3059\u3002\u4ee3\u8b1d\\\/\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u7814\u7a76\u3067\u306f\u3001MOTS-c\u304c\u30c7\u30d5\u30a9\u30eb\u30c8\u306e\u7b2c\u4e00\u9078\u629e\u3067\u3059\u3002\u5fc3\u81d3\u3001\u814e\u81d3\u3001\u307e\u305f\u306f\u865a\u8840\u518d\u704c\u6d41\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u4fdd\u8b77\u306b\u306fSS-31\u304c\u6a19\u6e96\u7684\u306a\u6bd4\u8f03\u5bfe\u8c61\u3067\u3059\u3002<\/p>\n<h2>\u4fdd\u7ba1\u65b9\u6cd5\u3068\u518d\u6eb6\u89e3<\/h2>\n<p><strong>\u518d\u6eb6\u89e3\u524d\uff1a<\/strong> \u51cd\u7d50\u4e7e\u71e5\u30d0\u30a4\u30a2\u30eb\u306f\u3001\u77ed\u671f\u4f7f\u7528\u30b9\u30c8\u30c3\u30af\u3068\u3057\u3066\u5143\u306e\u5305\u88c5\u306e\u307e\u307e2\uff5e8\u00b0C\u3067\u51b7\u8535\u4fdd\u5b58\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u672a\u958b\u5c01\u306e\u9577\u671f\u4fdd\u5b58\u3067\u306f\u3001-20\u00b0C\u3067\u51cd\u7d50\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u51cd\u7d50\u4e7e\u71e5MOTS-c\u306f\u3001\u51b7\u8535\u3067\u6700\u957724\u30f6\u6708\u3001-20\u00b0C\u3067\u6700\u957736\u30f6\u6708\u5b89\u5b9a\u3067\u3059\u3002\u51cd\u7d50\u4e7e\u71e5\u7c89\u672b\u306e\u51cd\u7d50\u878d\u89e3\u30b5\u30a4\u30af\u30eb\u306f\u907f\u3051\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<p><strong>\u518d\u6eb6\u89e3\u624b\u9806\uff1a<\/strong> \u6ce8\u5c04\u7528\u9759\u83cc\u6c34\u3092\u30da\u30d7\u30c1\u30c9\u30d0\u30a4\u30a2\u30eb\u306e\u5074\u58c1\u306b\u6cbf\u3063\u3066\u6ce8\u5165\u3057\u3066\u304f\u3060\u3055\u3044\uff08\u51cd\u7d50\u4e7e\u71e5\u30b1\u30fc\u30ad\u306b\u76f4\u63a5\u304b\u3051\u306a\u3044\u3067\u304f\u3060\u3055\u3044\uff09\u300210 mg\u30d0\u30a4\u30a2\u30eb\u306e\u5834\u5408\u30012.0 mL\u306e\u9759\u83cc\u6c34\u30675 mg\/mL\u306e\u4f7f\u7528\u6fc3\u5ea6\u304c\u5f97\u3089\u308c\u3001U-100\u30a4\u30f3\u30b9\u30ea\u30f3\u30b7\u30ea\u30f3\u30b8\u306e10\u76ee\u76db\u308a\u304c500 mcg\u306b\u76f8\u5f53\u3057\u307e\u3059\u3002\u9759\u304b\u306b\u3086\u3063\u304f\u308a\u3068\u6df7\u305c\u3001\u2014 \u884c\u3046 <strong>\u3057\u307e\u305b\u3093<\/strong> \u632f\u3063\u3066\u2014 \u5b8c\u5168\u306b\u6eb6\u89e3\u3059\u308b\u307e\u30672\uff5e5\u5206\u9593\u9759\u7f6e\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u6b63\u3057\u304f\u518d\u69cb\u6210\u3055\u308c\u305f\u6eb6\u6db2\u306f\u900f\u660e\u3067\u7121\u8272\u3067\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3002<\/p>\n<p><strong>\u5b8c\u5168\u306b\u518d\u6eb6\u89e3\u3057\u305f\u6eb6\u6db2\u306f\u3001\u7121\u8272\u900f\u660e\u3067\u3042\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/strong> 2\uff5e8\u00b0C\u3067\u51b7\u8535\u4fdd\u5b58\u3057\u3001\u6700\u9069\u306a\u5b89\u5b9a\u6027\u306e\u305f\u3081\u306b30\u65e5\u4ee5\u5185\u306b\u4f7f\u7528\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u518d\u69cb\u6210\u3057\u305f\u6eb6\u6db2\u306f\u51cd\u7d50\u3057\u306a\u3044\u3067\u304f\u3060\u3055\u3044 \u2014 \u51cd\u7d50\u878d\u89e3\u30b5\u30a4\u30af\u30eb\u306f\u30da\u30d7\u30c1\u30c9\u306e\u5b8c\u5168\u6027\u3092\u640d\u306a\u3044\u307e\u3059\u3002\u6fc1\u308a\u3001\u6c88\u6bbf\u3001\u307e\u305f\u306f\u5909\u8272\u304c\u898b\u3089\u308c\u308b\u30d0\u30a4\u30a2\u30eb\u306f\u5ec3\u68c4\u3057\u3066\u304f\u3060\u3055\u3044\u3002MOTS-c\u306f\u7814\u7a76\u30d7\u30ed\u30c8\u30b3\u30eb\u3067\u901a\u5e38\u90311\uff5e3\u56de\u6295\u4e0e\u3055\u308c\u308b\u305f\u3081\u3001\u518d\u69cb\u6210\u3057\u305f10mg\u30d0\u30a4\u30a2\u30eb1\u672c\u3067\u3001\u76ee\u6a19\u7528\u91cf\u3068\u983b\u5ea6\u306b\u5fdc\u3058\u3066\u901a\u5e382\uff5e3\u9031\u9593\u5206\u306e\u6295\u4e0e\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n<h2 id=\"faqs\">\u3088\u304f\u3042\u308b\u8cea\u554f<\/h2>\n<h3>MOTS-c\u306f\u7814\u7a76\u3067\u4f55\u306b\u4f7f\u7528\u3055\u308c\u307e\u3059\u304b\uff1f<\/h3>\n<p>MOTS-c\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u30012\u578b\u7cd6\u5c3f\u75c5\u30e2\u30c7\u30eb\u3001\u904b\u52d5\u80fd\u529b\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u65b0\u751f\u3001\u8001\u5316\u3068\u5bff\u547d\u3001\u5fc3\u8840\u7ba1\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\u3001\u814e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u969c\u5bb3\u3001\u9aa8\u306e\u5065\u5eb7\u3092\u8abf\u67fb\u3059\u308b\u5b9f\u9a13\u5ba4\u7814\u7a76\u3067\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u306f\u767a\u8868\u6587\u732e\u3067\u6700\u3082\u5f15\u7528\u3055\u308c\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30b3\u30fc\u30c9\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30da\u30d7\u30c1\u30c9\u3067\u3042\u308a\u3001AMPK\u8ef8\u4ecb\u5165\u306e\u30d9\u30f3\u30c1\u30de\u30fc\u30af\u3068\u3057\u3066\u6a5f\u80fd\u3057\u307e\u3059\u3002MOTS-c\u306f <strong>\u3057\u307e\u305b\u3093<\/strong> FDA\u627f\u8a8d\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u3053\u3067\u306f\u53b3\u5bc6\u306b\u5b9f\u9a13\u5ba4\u7814\u7a76\u7528\u3068\u3057\u3066\u306e\u307f\u63d0\u4f9b\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3>MOTS-c\u306fSS-31\uff08\u30a8\u30e9\u30df\u30d7\u30ec\u30c1\u30c9\uff09\u3068\u3069\u306e\u3088\u3046\u306b\u7570\u306a\u308a\u307e\u3059\u304b\uff1f<\/h3>\n<p>MOTS-c\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u306b\u30b3\u30fc\u30c9\u3055\u308c\u308b16\u30a2\u30df\u30ce\u9178\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30da\u30d7\u30c1\u30c9\u3067\u3001AMPK\u3092\u6d3b\u6027\u5316\u3057\u6838\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u8abf\u7bc0\u3057\u307e\u3059\u3002SS-31\u306f\u3001\u96fb\u5b50\u4f1d\u9054\u7cfb\u3092\u5b89\u5b9a\u5316\u3055\u305b\u308b\u305f\u3081\u306b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5185\u819c\u306e\u30ab\u30eb\u30b8\u30aa\u30ea\u30d4\u30f3\u306b\u7d50\u5408\u3059\u308b\u30014\u30a2\u30df\u30ce\u9178\u306e\u5408\u6210Szeto-Schiller\u30da\u30d7\u30c1\u30c9\u3067\u3059\u3002\u4e21\u8005\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u751f\u7269\u5b66\u306e\u7570\u306a\u308b\u968e\u5c64\u306b\u5bfe\u5fdc\u3057 \u2014 MOTS-c\u306f\u4ee3\u8b1d\u8ee2\u5199\u30ec\u30d9\u30eb\u3067\u3001SS-31\u306f\u819c\u69cb\u9020\u30ec\u30d9\u30eb\u3067 \u2014 \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u969c\u5bb3\u7814\u7a76\u3067\u3057\u3070\u3057\u3070\u4f75\u7528\u3055\u308c\u307e\u3059\u3002<\/p>\n<h3>MOTS-c\u306e\u7814\u7a76\u306b\u304a\u3051\u308b\u4e00\u822c\u7684\u306a\u7528\u91cf\u306f\u3069\u306e\u304f\u3089\u3044\u3067\u3059\u304b\uff1f<\/h3>\n<p>\u516c\u8868\u3055\u308c\u3066\u3044\u308b\u524d\u81e8\u5e8a\u30d7\u30ed\u30c8\u30b3\u30eb\u3067\u306f\u3001\u3052\u3063\u6b6f\u985e\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3001\u901a\u5e381\u56de\u3042\u305f\u308a5\uff5e15 mg\u3092\u3001\u90311\uff5e3\u56de\u30014\uff5e12\u9031\u9593\u306e\u30b5\u30a4\u30af\u30eb\u3067\u6295\u4e0e\u3057\u307e\u3059\u300210 mg\u306e\u30d0\u30a4\u30a2\u30eb\u30922.0 mL\u306e\u9759\u83cc\u6c34\u3067\u6eb6\u89e3\u3059\u308b\u30685 mg\/mL\u306e\u6fc3\u5ea6\u306b\u306a\u308a\u3001U-100\u30b7\u30ea\u30f3\u30b8\u306e10\u76ee\u76db\u308a\u304c500 mcg\u306b\u76f8\u5f53\u3057\u307e\u3059\u3002<\/p>\n<h3>MOTS-c\u306fFDA\u627f\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u304b\uff1f<\/h3>\n<p>\u3044\u3044\u3048\u3002MOTS-c\u306fFDA\u3001EMA\u3001MHRA\u3001\u305d\u306e\u4ed6\u306e\u898f\u5236\u5f53\u5c40\u306b\u3088\u3063\u3066\u30d2\u30c8\u306e\u6cbb\u7642\u7528\u9014\u3068\u3057\u3066\u627f\u8a8d\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u7814\u7a76\u7528\u306e\u307f\u306e\u4f9b\u7d66\u696d\u8005\u304c\u8ca9\u58f2\u3059\u308b\u3059\u3079\u3066\u306eMOTS-c\u306f\u5b9f\u9a13\u5ba4\u3067\u306e\u7814\u7a76\u7528\u3067\u3042\u308a\u3001\u30d2\u30c8\u3084\u52d5\u7269\u306b\u6295\u4e0e\u3059\u3079\u304d\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<h3>MOTS-c\u306f\u3069\u306e\u3088\u3046\u306b\u4fdd\u7ba1\u3059\u308c\u3070\u3088\u3044\u3067\u3059\u304b\uff1f<\/h3>\n<p>\u51cd\u7d50\u4e7e\u71e5\u30d0\u30a4\u30a2\u30eb\uff1a\u77ed\u671f\u4f7f\u7528\u306e\u4f5c\u696d\u7528\u30b9\u30c8\u30c3\u30af\u306f2\uff5e8\u00b0C\u3067\u51b7\u8535\u4fdd\u5b58\u3001\u672a\u958b\u5c01\u30d0\u30a4\u30a2\u30eb\u306e\u9577\u671f\u4fdd\u5b58\u306f-20\u00b0C\u3067\u4fdd\u7ba1\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u518d\u6eb6\u89e3\u5f8c\u306e\u6eb6\u6db2\uff1a2\uff5e8\u00b0C\u3067\u51b7\u8535\u4fdd\u5b58\u3057\u300130\u65e5\u4ee5\u5185\u306b\u4f7f\u7528\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u518d\u6eb6\u89e3\u5f8c\u306e\u6eb6\u6db2\u306f\u51cd\u7d50\u3057\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002\u51cd\u7d50\u878d\u89e3\u30b5\u30a4\u30af\u30eb\u306b\u3088\u308a\u30da\u30d7\u30c1\u30c9\u304c\u5206\u89e3\u3055\u308c\u307e\u3059\u3002\u5e38\u306b\u76f4\u5c04\u5149\u3092\u907f\u3051\u3066\u4fdd\u8b77\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<h3>MOTS-c\u306e\u6eb6\u89e3\u65b9\u6cd5\u3092\u6559\u3048\u3066\u304f\u3060\u3055\u3044\u3002<\/h3>\n<p>\u4e0a\u8a18\u306e\u518d\u6eb6\u89e3\u624b\u9806\u306b\u5f93\u3063\u3066\u304f\u3060\u3055\u3044\u3002\u6ce8\u5c04\u7528\u9759\u83cc\u6c34\u3092\u30d0\u30a4\u30a2\u30eb\u306e\u5185\u58c1\u306b\u6cbf\u3063\u3066\uff08\u51cd\u7d50\u4e7e\u71e5\u30b1\u30fc\u30ad\u306b\u76f4\u63a5\u5f53\u3066\u306a\u3044\u3088\u3046\u306b\uff09\u52a0\u3048\u3001\u9759\u304b\u306b\u65cb\u56de\u3055\u305b\u3001\u5b8c\u5168\u306b\u6eb6\u89e3\u3059\u308b\u307e\u30672\uff5e5\u5206\u9593\u7f6e\u304d\u307e\u3059\u3002 <strong>\u3057\u307e\u305b\u3093<\/strong> \u30d0\u30a4\u30a2\u30eb\u3092\u632f\u3089\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002\u6b63\u3057\u304f\u518d\u6eb6\u89e3\u3055\u308c\u305f\u6eb6\u6db2\u306f\u900f\u660e\u3067\u7121\u8272\u3067\u3059\u300210 mg\u30d0\u30a4\u30a2\u30eb\u306b2.0 mL\u306e\u6eb6\u89e3\u6db2\u3092\u52a0\u3048\u305f\u5834\u5408\u3001\u4f5c\u696d\u6fc3\u5ea6\u306f5 mg\/mL\u3067\u3059\u3002<\/p>\n<h3>MedsBase\u3067\u306f\u3069\u306e\u5bb9\u91cf\u306e\u30ec\u30bf\u30eb\u30c8\u30eb\u30c1\u30c9\u3092\u53d6\u308a\u63c3\u3048\u3066\u3044\u307e\u3059\u304b\uff1f<\/h3>\n<p>MedsBase\u3067\u306f\u3001MOTS-c\u309210 mg\u300120 mg\u300140 mg\u306e\u51cd\u7d50\u4e7e\u71e5\u30d0\u30a4\u30a2\u30eb\u3067\u53d6\u308a\u6271\u3063\u3066\u3044\u307e\u3059\u3002\u5404\u5bb9\u91cf\u3068\u308210\u30d0\u30a4\u30a2\u30eb\u5165\u308a\u307e\u305f\u306f20\u30d0\u30a4\u30a2\u30eb\u5165\u308a\u306e\u30d1\u30c3\u30af\u30b5\u30a4\u30ba\u304b\u3089\u304a\u9078\u3073\u3044\u305f\u3060\u3051\u307e\u3059\u3002\u3059\u3079\u3066\u306e\u30d0\u30a4\u30a2\u30eb\u306f99%\u4ee5\u4e0a\u306eHPLC\u7d14\u5ea6\u3067\u4f9b\u7d66\u3055\u308c\u3001\u3054\u8981\u671b\u306b\u5fdc\u3058\u3066\u5206\u6790\u8a3c\u660e\u66f8\u3082\u3054\u5229\u7528\u3044\u305f\u3060\u3051\u307e\u3059\u3002<\/p>\n<h3>MOTS-c\u304c\u300c\u904b\u52d5\u6a21\u5023\u300d\u30da\u30d7\u30c1\u30c9\u3068\u547c\u3070\u308c\u308b\u7406\u7531\u306f\u4f55\u3067\u3059\u304b\uff1f<\/h3>\n<p>\u3053\u306e\u547c\u79f0\u306f\u3001MOTS-c\u304cAMPK\u3092\u6d3b\u6027\u5316\u3057\u3001\u30b0\u30eb\u30b3\u30fc\u30b9\u53d6\u308a\u8fbc\u307f\u3001\u8102\u80aa\u9178\u9178\u5316\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u751f\u5408\u6210\u306b\u4e0b\u6d41\u306e\u52b9\u679c\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u306b\u7531\u6765\u3057\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u904b\u52d5\u306b\u3088\u308b\u4ee3\u8b1d\u9069\u5fdc\u306e\u591a\u304f\u306b\u95a2\u4e0e\u3059\u308b\u7d30\u80de\u5185\u7d4c\u8def\u3068\u540c\u3058\u3067\u3059\u3002\u516c\u8868\u3055\u308c\u305f\u7814\u7a76\u3067\u306f\u3001MOTS-c\u306e\u6295\u4e0e\u306b\u3088\u308a\u3001\u904b\u52d5\u4e0d\u8db3\u306e\u52d5\u7269\u306b\u304a\u3044\u3066\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u306e\u6539\u5584\u3001\u30c8\u30ec\u30c3\u30c9\u30df\u30eb\u6301\u4e45\u529b\u306e\u5411\u4e0a\u3001\u9aa8\u683c\u7b4b\u306b\u304a\u3051\u308bPGC-1\u03b1\u767a\u73fe\u306e\u5897\u52a0\u306a\u3069\u3001\u904b\u52d5\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306b\u898b\u3089\u308c\u308b\u8907\u6570\u306e\u8868\u73fe\u578b\u304c\u518d\u73fe\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u6bd4\u55a9\u306f\u3001\u8001\u5e74\u79d1\u5b66\u3084\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u306e\u6587\u732e\u3067\u5e83\u304f\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3>\u7814\u7a76\u306b\u304a\u3044\u3066MOTS-c\u3068SS-31\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u306f\u53ef\u80fd\u3067\u3059\u304b\uff1f<\/h3>\n<p>\u306f\u3044\u3002MOTS-c\u3068SS-31\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u751f\u7269\u5b66\u306e\u7570\u306a\u308b\u5c64\u306b\u4f5c\u7528\u3057\u3001\u524d\u81e8\u5e8a\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u969c\u5bb3\u7814\u7a76\u3067\u306f\u4f75\u7528\u3055\u308c\u308b\u3053\u3068\u304c\u3088\u304f\u3042\u308a\u307e\u3059\u3002MOTS-c\u306fAMPK\u3092\u4ecb\u3057\u3066\u4ee3\u8b1d\u8ee2\u5199\u3092\u8abf\u7bc0\u3057\u3001SS-31\u306f\u5185\u819c\u306e\u8102\u8cea\u74b0\u5883\u3092\u5b89\u5b9a\u5316\u3055\u305b\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u91cd\u8907\u3059\u308b\u306e\u3067\u306f\u306a\u304f\u88dc\u5b8c\u7684\u3067\u3042\u308b\u305f\u3081\u3001\u591a\u8ef8\u7684\u306a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u4f4e\u4e0b\u306e\u7814\u7a76\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u7d44\u307f\u5408\u308f\u305b\u304c\u6709\u7528\u3067\u3059\u3002<\/p>\n<h3>MOTS-c\u306f\u7814\u7a76\u306b\u304a\u3044\u3066\u526f\u4f5c\u7528\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u304b\uff1f<\/h3>\n<p>\u516c\u8868\u3055\u308c\u3066\u3044\u308b\u524d\u81e8\u5e8a\u7814\u7a76\u3067\u306f\u3001\u3052\u3063\u6b6f\u985e\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u901a\u5e38\u306e\u7814\u7a76\u7528\u91cf\u3067\u9855\u8457\u306b\u30af\u30ea\u30fc\u30f3\u306a\u5b89\u5168\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u4e00\u8cab\u3057\u305f\u30aa\u30d5\u30bf\u30fc\u30b2\u30c3\u30c8\u30b7\u30b0\u30ca\u30eb\u306f\u898b\u3089\u308c\u305a\u30014\uff5e12\u9031\u9593\u306e\u6295\u4e0e\u30b5\u30a4\u30af\u30eb\u3092\u901a\u3058\u3066\u826f\u597d\u306a\u5fcd\u5bb9\u6027\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002MOTS-c\u306f\u69cb\u9020\u7684\u306b\u30d2\u30c8\u5185\u5728\u6027\u30da\u30d7\u30c1\u30c9\u3067\u3042\u308b\u305f\u3081\u3001\u4eba\u5de5\u7684\u306b\u8a2d\u8a08\u3055\u308c\u305f\u30a2\u30ca\u30ed\u30b0\u3067\u898b\u3089\u308c\u308b\u6297\u4f53\u4ecb\u5728\u6027\u53cd\u5fdc\u306e\u30ea\u30b9\u30af\u304c\u4f4e\u6e1b\u3055\u308c\u307e\u3059\u3002\u30d2\u30c8\u3067\u306e\u9577\u671f\u5b89\u5168\u6027\u30c7\u30fc\u30bf\u306f\u3001\u81e8\u5e8a\u8a66\u9a13\u304c\u307e\u3060\u521d\u671f\u6bb5\u968e\u306b\u3042\u308b\u305f\u3081\u5229\u7528\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n<h3>MOTS-c\u306e\u534a\u6e1b\u671f\u306f\u3069\u306e\u304f\u3089\u3044\u3067\u3059\u304b\uff1f<\/h3>\n<p>\u524d\u81e8\u5e8a\u7814\u7a76\u306b\u304a\u3044\u3066\u3001MOTS-c\u306e\u8840\u6f3f\u4e2d\u534a\u6e1b\u671f\u306f\u76ae\u4e0b\u6295\u4e0e\u5f8c\u7d043\uff5e4\u6642\u9593\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u6bd4\u8f03\u7684\u77ed\u3044\u5168\u8eab\u534a\u6e1b\u671f\u306f\u3001\u7d30\u80de\u5185\u84c4\u7a4d\u3068\u3001MOTS-c\u304c\u5faa\u74b0\u30db\u30eb\u30e2\u30f3\u3067\u306f\u306a\u304f\u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u5206\u5b50\u3068\u3057\u3066\u50cd\u304f\u3053\u3068\u306b\u3088\u3063\u3066\u76f8\u6bba\u3055\u308c\u3001\u7814\u7a76\u30e2\u30c7\u30eb\u3067\u306f\u8840\u6f3f\u4e2d\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u306e\u6642\u9593\u67a0\u3092\u8d85\u3048\u3066\u52b9\u679c\u304c\u6301\u7d9a\u3057\u307e\u3059\u3002<\/p>\n<h3>\u306a\u305c\u52a0\u9f62\u3068\u3068\u3082\u306b\u5185\u56e0\u6027MOTS-c\u306f\u6e1b\u5c11\u3059\u308b\u306e\u3067\u3059\u304b\uff1f<\/h3>\n<p>\u516c\u8868\u3055\u308c\u305f\u30b3\u30db\u30fc\u30c8\u30c7\u30fc\u30bf\u3067\u306f\u3001\u82e5\u5e74\u6210\u4eba\u3068\u9ad8\u9f62\u6210\u4eba\u306e\u9593\u3067\u30d2\u30c8\u8840\u6e05\u4e2d\u306eMOTS-c\u30ec\u30d9\u30eb\u304c\u7d0450\uff05\u6e1b\u5c11\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u5b8c\u5168\u306b\u306f\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u52a0\u9f62\u306b\u4f34\u3046\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u306e\u5909\u7570\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u8ee2\u5199\u306e\u4f4e\u4e0b\u3001\u304a\u3088\u3073\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u30b3\u30fc\u30c9\u3055\u308c\u305f\u30da\u30d7\u30c1\u30c9\u306e\u751f\u5408\u6210\u5168\u822c\u306e\u4f4e\u4e0b\u306b\u95a2\u9023\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u52a0\u9f62\u306b\u4f34\u3046\u6e1b\u5c11\u306f\u3001MOTS-c\u304c\u9577\u5bff\u5b66\u3084\u8001\u5e74\u79d1\u5b66\u7814\u7a76\u306b\u304a\u3044\u3066\u5f37\u3044\u95a2\u5fc3\u3092\u96c6\u3081\u3066\u3044\u308b\u7406\u7531\u306e\u4e00\u3064\u3067\u3059\u3002<\/p>\n<h3>\u524d\u81e8\u5e8a\u7814\u7a76\u306b\u304a\u3044\u3066MOTS-c\u306e\u52b9\u679c\u304c\u73fe\u308c\u308b\u307e\u3067\u3069\u306e\u304f\u3089\u3044\u306e\u6642\u9593\u304c\u304b\u304b\u308a\u307e\u3059\u304b\uff1f<\/h3>\n<p>AMPK\u30ea\u30f3\u9178\u5316\u304a\u3088\u3073\u30b0\u30eb\u30b3\u30fc\u30b9\u53d6\u308a\u8fbc\u307f\u306b\u5bfe\u3059\u308b\u6025\u6027\u52b9\u679c\u306f\u3001\u6295\u4e0e\u5f8c\u6570\u6642\u9593\u4ee5\u5185\u306b\u691c\u51fa\u53ef\u80fd\u3067\u3059\u3002\u9ad8\u8102\u80aa\u98df\u3092\u4e0e\u3048\u305f\u3052\u3063\u6b6f\u985e\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u304a\u3088\u3073\u4f53\u7d44\u6210\u3078\u306e\u5f71\u97ff\u306f\u3001\u901a\u5e382\uff5e4\u9031\u9593\u306e\u5b9a\u671f\u7684\u306a\u6295\u4e0e\u5f8c\u306b\u7d71\u8a08\u7684\u306b\u6709\u610f\u306b\u306a\u308a\u307e\u3059\u3002\u904b\u52d5\u80fd\u529b\u306e\u6539\u5584\uff08\u30c8\u30ec\u30c3\u30c9\u30df\u30eb\u6301\u4e45\u529b\u3001VO<sub>2<\/sub>\u4ee3\u7528\u6307\u6a19\uff09\u306f\u30014\uff5e8\u9031\u9593\u306e\u7d99\u7d9a\u7684\u306a\u7814\u7a76\u7528\u91cf\u6295\u4e0e\u3067\u84c4\u7a4d\u3055\u308c\u307e\u3059\u3002<\/p>\n<h3>MOTS-c\u3092\u56fd\u969b\u914d\u9001\u3067\u6ce8\u6587\u3067\u304d\u307e\u3059\u304b\uff1f<\/h3>\n<p>\u306f\u3044\u3002MedsBase\u306f\u3001\u5c02\u7528\u306e\u30da\u30d7\u30c1\u30c9\u767a\u9001\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u304b\u3089MOTS-c\u3092\u5168\u4e16\u754c\u914d\u9001\u3057\u3066\u3044\u307e\u3059\u3002\u30da\u30d7\u30c1\u30c9\u306e\u307f\u306e\u3054\u6ce8\u6587\u306f\u3001\u5f53\u793e\u306e\u5358\u72ec\u30da\u30d7\u30c1\u30c9\u767a\u9001\u30b5\u30fc\u30d3\u30b9\u306e\u5bfe\u8c61\u3068\u306a\u308a\u307e\u3059\u3002\u3059\u3079\u3066\u306e\u3054\u6ce8\u6587\u306f\u3001\u6e29\u5ea6\u7ba1\u7406\u3055\u308c\u305f\u68b1\u5305\u3067\u8ffd\u8de1\u4ed8\u304d\u3067\u767a\u9001\u3055\u308c\u3001\u5f53\u793e\u306e <a href=\"https:\/\/medsbase.com\/ja\/medsbase-re-shipment-assurance-policy\/\">\u518d\u767a\u9001\u4fdd\u8a3c\u30dd\u30ea\u30b7\u30fc<\/a>.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>\u4ee3\u8b1d\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3001\u9577\u5bff\u7814\u7a76\u7528\u306e\u305d\u306e\u4ed6\u306e\u30da\u30d7\u30c1\u30c9<\/h2>\n<ul>\n<li><a href=\"\/ja\/ss-31-elamipretide\/\"><strong>SS-31 (Elamipretide)<\/strong><\/a> \u2014 \u30ab\u30eb\u30b8\u30aa\u30ea\u30d4\u30f3\u7d50\u5408\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30c6\u30c8\u30e9\u30da\u30d7\u30c1\u30c9 \u2014 \u6a19\u6e96\u7684\u306a\u5185\u819c\u5b89\u5b9a\u5316\u5264<\/li>\n<li><a href=\"\/ja\/nad\/\"><strong>NAD+<\/strong><\/a> \u2014 \u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u30a2\u30c7\u30cb\u30f3\u30b8\u30cc\u30af\u30ec\u30aa\u30c1\u30c9 \u2014 \u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\uff0f\u9577\u5bff\u8ef8\u4ee3\u8b1d\u7814\u7a76<\/li>\n<li><a href=\"\/ja\/epitalon\/\"><strong>Epitalon<\/strong><\/a> \u2014 AEDG\u677e\u679c\u4f53\u30c6\u30c8\u30e9\u30da\u30d7\u30c1\u30c9 \u2014 \u30c6\u30ed\u30e1\u30e9\u30fc\u30bc\u6d3b\u6027\u5316\u3068\u9577\u5bff\u7814\u7a76<\/li>\n<li><a href=\"\/ja\/semaglutide\/\"><strong>\u30bb\u30de\u30b0\u30eb\u30c1\u30c9<\/strong><\/a> \u2014 \u9577\u6642\u9593\u4f5c\u7528\u578bGLP-1\u4f5c\u52d5\u85ac \u2014 \u8840\u7cd6\u304a\u3088\u3073\u4f53\u91cd\u7814\u7a76<\/li>\n<li><a href=\"\/ja\/retatrutide\/\"><strong>Retatrutide<\/strong><\/a> \u2014 \u30c8\u30ea\u30d7\u30ebGLP-1\/GIP\/\u30b0\u30eb\u30ab\u30b4\u30f3\u4f5c\u52d5\u85ac \u2014 \u591a\u8ef8\u4ee3\u8b1d\u7814\u7a76<\/li>\n<\/ul>\n<p><!-- medsbase-peptide-guide-cta --><\/p>\n<h2>\u53c2\u8003\u6587\u732e<\/h2>\n<div style=\"background: #f4f8fb; border-left: 4px solid #2c7cb0; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<p style=\"margin: 0 0 8px 0;\"><strong>\ud83d\udcd6 \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a19\u7684\u30da\u30d7\u30c1\u30c9\u3092\u6bd4\u8f03\u3059\u308b<\/strong><\/p>\n<p style=\"margin: 0;\">\u3088\u308a\u5e83\u7bc4\u306a <a href=\"https:\/\/medsbase.com\/ja\/peptides\/\"><strong>\u7814\u7a76\u7528\u30da\u30d7\u30c1\u30c9\u30ab\u30bf\u30ed\u30b0<\/strong><\/a> \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304a\u3088\u3073\u4ee3\u8b1d\u30da\u30d7\u30c1\u30c9\u7528\uff08\u4ee5\u4e0b\u3092\u542b\u3080\uff09 <a href=\"https:\/\/medsbase.com\/ja\/ss-31-elamipretide\/\">SS-31 (Elamipretide)<\/a> \u30ab\u30eb\u30b8\u30aa\u30ea\u30d4\u30f3\u6a19\u7684\u819c\u7814\u7a76\u7528\u3001, <a href=\"https:\/\/medsbase.com\/ja\/nad\/\">NAD+<\/a> \u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u8ef8\u9577\u5bff\u7814\u7a76\u7528\u3001\u304a\u3088\u3073 <a href=\"https:\/\/medsbase.com\/ja\/epitalon\/\">Epitalon<\/a> \u30c6\u30ed\u30e1\u30a2\u8ef8\u9577\u5bff\u7814\u7a76\u7528\u3002<\/p>\n<\/div>\n<p><!-- pep-seo-v1 --><\/p>","protected":false},"excerpt":{"rendered":"<p>\u2705 \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u30b3\u30fc\u30c9\u3055\u308c\u305f\u30b7\u30b0\u30ca\u30eb\u30da\u30d7\u30c1\u30c9<br \/>\n\u2705 AMPK\u4ee3\u8b1d\u7d4c\u8def\u3092\u6d3b\u6027\u5316<br \/>\n\u2705 \u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u7814\u7a76\u3092\u30b5\u30dd\u30fc\u30c8<br \/>\n\u2705 \u524d\u81e8\u5e8a\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u904b\u52d5\u6a21\u5023\u5316\u5408\u7269<br \/>\n\u2705 \u9577\u5bff\u30fb\u30b8\u30a7\u30ed\u30b5\u30a4\u30a8\u30f3\u30b9\u7814\u7a76\u5316\u5408\u7269<\/p>\n<p><strong>MOTS-c<\/strong> \u5408\u6210\u30da\u30d7\u30c1\u30c9\u5316\u5408\u7269\u3092\u542b\u307f\u307e\u3059\u3002<\/p>","protected":false},"featured_media":70967,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[5426],"product_tag":[6272,5441],"class_list":{"0":"post-70664","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptides","7":"product_tag-mots-c","8":"product_tag-peptide","10":"first","11":"instock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable","15":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ja\/wp-json\/wp\/v2\/product\/70664","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ja\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ja\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ja\/wp-json\/wp\/v2\/comments?post=70664"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ja\/wp-json\/wp\/v2\/media\/70967"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ja\/wp-json\/wp\/v2\/media?parent=70664"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ja\/wp-json\/wp\/v2\/product_brand?post=70664"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ja\/wp-json\/wp\/v2\/product_cat?post=70664"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ja\/wp-json\/wp\/v2\/product_tag?post=70664"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}