{"id":70729,"date":"2026-05-12T10:06:21","date_gmt":"2026-05-12T10:06:21","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&#038;p=70729"},"modified":"2026-05-21T07:14:10","modified_gmt":"2026-05-21T07:14:10","slug":"gdf-8","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ja\/product\/gdf-8\/","title":{"rendered":"GDF-8 (Myostatin)"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background: #fff8e1; border-left: 4px solid #f5a623; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<h3 style=\"margin: 0 0 8px 0; font-size: 16px; color: #1a4a6b;\">\u30af\u30a4\u30c3\u30af\u30a2\u30f3\u30b5\u30fc \u2014 GDF-8\uff08\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\uff09\u3068\u306f\u4f55\u3067\u3059\u304b\uff1f<\/h3>\n<p style=\"margin: 0;\"><strong>GDF-8<\/strong> \uff08\u6210\u9577\u5206\u5316\u56e0\u5b508\uff09\u306f\u3001\u5225\u540d <strong>\u30df\u30aa\u30b9\u30bf\u30c1\u30f3<\/strong>, \u306f\u3001\u7d44\u63db\u3048TGF-\u03b2\u30b9\u30fc\u30d1\u30fc\u30d5\u30a1\u30df\u30ea\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u3001\u9aa8\u683c\u7b4b\u91cf\u306e\u4e3b\u8981\u306a\u5185\u56e0\u6027\u8ca0\u306e\u8abf\u7bc0\u56e0\u5b50\u3067\u3059\u3002\u6a5f\u80fd\u55aa\u5931\u578b\u5909\u7570\u306f\u3001\u30de\u30a6\u30b9\u3001\u30a6\u30b7\u3001\u30a4\u30cc\u3001\u304a\u3088\u30731\u4f8b\u306e\u30d2\u30c8\u3067\u3088\u304f\u77e5\u3089\u308c\u308b\u300c\u4e8c\u91cd\u7b4b\u8089\u300d\u8868\u73fe\u578b\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u767a\u8868\u3055\u308c\u305f\u7814\u7a76\u3067\u306f\u3001\u7d44\u63db\u3048GDF-8\u306f\u7d4c\u8def\u523a\u6fc0\u30c4\u30fc\u30eb\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u3001\u840e\u7e2e\u8868\u73fe\u578b\u306e\u8a98\u5c0e\u3001\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u62ee\u6297\u85ac\uff08\u4f8b\uff1a <a href=\"https:\/\/medsbase.com\/ja\/follistatin-344\/\">follistatin 344<\/a>, \u3001\u304a\u3088\u3073Smad2\/Smad3\u4e0b\u6d41\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u7279\u6027\u8a55\u4fa1\u306b\u4f7f\u7528\u3055\u308c\u307e\u3059\u30021 mg\u306e\u51cd\u7d50\u4e7e\u71e5\u30d0\u30a4\u30a2\u30eb\u3067\u63d0\u4f9b\u3055\u308c\u3001\u5b9f\u9a13\u5ba4\u7814\u7a76\u7528\u306e\u307f\u3067\u3059\u3002<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background: #f4f8fb; border: 1px solid #d8e3eb; padding: 12px 16px; margin: 16px 0; border-radius: 4px; font-size: 14px;\"><strong>MedsBase\u3067\u5f97\u3089\u308c\u308b\u3082\u306e\uff1a<\/strong> \u7814\u7a76\u7528\u51cd\u7d50\u4e7e\u71e5\u7d44\u63db\u3048\u30bf\u30f3\u30d1\u30af\u8cea \u00b7 HPLC\u7d14\u5ea695%\u4ee5\u4e0a\uff08\u5206\u6790\u8a3c\u660e\u66f8\u306f\u3054\u8981\u671b\u306b\u5fdc\u3058\u3066\uff09 \u00b7 \u4e2d\u8eab\u304c\u308f\u304b\u3089\u306a\u3044\u6e29\u5ea6\u5b89\u5b9a\u6027\u68b1\u5305 \u00b7 \u30da\u30d7\u30c1\u30c9\u306e\u5168\u4e16\u754c\u914d\u9001 \u00b7 1,400\u4ef6\u4ee5\u4e0a\u306e\u78ba\u8a8d\u6e08\u307f\u30ec\u30d3\u30e5\u30fc <a href=\"https:\/\/medsbase.com\/ja\/reviews\/\">\u30ab\u30b9\u30bf\u30de\u30fc\u30ec\u30d3\u30e5\u30fc<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size: 14px; color: #444; margin: 8px 0 18px;\">\ud83d\udce6 \u3059\u3079\u3066\u306e\u3054\u6ce8\u6587\u306f\u3001\u5f53\u5e97\u306e <a href=\"https:\/\/medsbase.com\/ja\/medsbase-re-shipment-assurance-policy\/\"><strong>\u518d\u767a\u9001\u4fdd\u8a3c\u30dd\u30ea\u30b7\u30fc<\/strong><\/a> \u2014 \u4e07\u304c\u4e00\u300120\u55b6\u696d\u65e5\u4ee5\u5185\u306b\u5546\u54c1\u304c\u5c4a\u304b\u306a\u3044\u5834\u5408\u306f\u3001\u518d\u767a\u9001\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n<table class=\"medsbase-spec-table\" style=\"width: 100%; border-collapse: collapse; margin: 18px 0; font-size: 14px;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 8px 12px; text-align: left; width: 30%;\">\u4ed5\u69d8<\/th>\n<th style=\"padding: 8px 12px; text-align: left;\">\u8a73\u7d30<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>CAS\u756a\u53f7<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u6210\u719f\u4e8c\u91cf\u4f53\uff08\u7d44\u63db\u3048\u30bf\u30f3\u30d1\u30af\u8cea\uff09\u3068\u3057\u3066\u6b63\u5f0f\u306b\u306f\u767b\u9332\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002MSTN\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u30b3\u30fc\u30c9\u3055\u308c\u3001UniProt O14793<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u30bf\u30a4\u30d7<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u7d44\u63db\u3048\u30bf\u30f3\u30d1\u30af\u8cea\uff08TGF-\u03b2\u30b9\u30fc\u30d1\u30fc\u30d5\u30a1\u30df\u30ea\u30fc\u30ea\u30ac\u30f3\u30c9\uff1b\u6210\u719f\u578b109\u30a2\u30df\u30ce\u9178C\u672b\u7aef\u30b8\u30b9\u30eb\u30d5\u30a3\u30c9\u7d50\u5408\u30db\u30e2\u4e8c\u91cf\u4f53\u3001375-aa\u30d7\u30ec\u30d7\u30ed\u30bf\u30f3\u30d1\u30af\u8cea\u524d\u99c6\u4f53\u304b\u3089\u5207\u65ad\uff09<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u5206\u5b50\u91cf<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u7d0425.8 kDa\uff08\u6210\u719f\u30db\u30e2\u4e8c\u91cf\u4f53\uff1b\u30e2\u30ce\u30de\u30fc\u9396\u3042\u305f\u308a\u7d0412.9 kDa\uff09<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u69cb\u9020<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u6210\u719f\u578b109-aa\u30e2\u30ce\u30de\u30fc\u3001\u6a19\u6e96\u7684\u306aTGF-\u03b2\u30b9\u30fc\u30d1\u30fc\u30d5\u30a1\u30df\u30ea\u30fc\u30b7\u30b9\u30c1\u30f3\u30ce\u30c3\u30c8\u30d5\u30a9\u30fc\u30eb\u30c9\u3092\u6709\u3059\u308b\uff1b2\u3064\u306e\u30e2\u30ce\u30de\u30fc\u304c\u5206\u5b50\u9593\u30b8\u30b9\u30eb\u30d5\u30a3\u30c9\u7d50\u5408\u306b\u3088\u3063\u3066\u5171\u6709\u7d50\u5408\u3057\u3001\u751f\u7269\u5b66\u7684\u306b\u6d3b\u6027\u306a\u30db\u30e2\u4e8c\u91cf\u4f53\u3092\u5f62\u6210\uff1b\u53d7\u5bb9\u4f53\u7d50\u5408\u9762\u306fActRIIB\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u3002<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u5f62\u614b<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u51cd\u7d50\u4e7e\u71e5\u7d44\u63db\u3048\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u767d\u8272\uff5e\u5fae\u9ec4\u8272\uff09<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u7d14\u5ea6<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u226595%\uff08HPLC\u691c\u8a3c\u6e08\u307f\u3001\u5206\u6790\u8a3c\u660e\u66f8\u306f\u3054\u8981\u671b\u306b\u5fdc\u3058\u3066\uff09<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u4fdd\u7ba1\u65b9\u6cd5<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u51cd\u7d50\u4e7e\u71e5\u54c1\uff1a\u4f5c\u696d\u7528\u30b9\u30c8\u30c3\u30af\u306f2\uff5e8\u00b0C\uff08\u51b7\u8535\u5eab\uff09\u3001\u672a\u958b\u5c01\u30d0\u30a4\u30a2\u30eb\u306e\u9577\u671f\u4fdd\u7ba1\u306f\u221220\u00b0C\u3067\u3059\u3002\u518d\u6eb6\u89e3\u5f8c\uff1a2\uff5e8\u00b0C\u3067\u7d0430\u65e5\u4ee5\u5185\u306b\u3054\u4f7f\u7528\u304f\u3060\u3055\u3044\u3002\u5149\u304b\u3089\u4fdd\u8b77\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u518d\u6eb6\u89e3\u6db2\u306e\u51cd\u7d50\u878d\u89e3\u306f\u907f\u3051\u3066\u304f\u3060\u3055\u3044 \u2014 \u7d44\u63db\u3048\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u7279\u306b\u51cd\u7d50\u878d\u89e3\u306b\u3088\u308b\u5909\u6027\u3092\u53d7\u3051\u3084\u3059\u3044\u305f\u3081\u3067\u3059\u3002<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u6eb6\u89e3\u6027<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u9759\u83cc\u6c34\uff08\u63a8\u5968\uff09\u307e\u305f\u306f\u77ed\u3044\u4f7f\u7528\u671f\u9593\u306e\u5834\u5408\u306f\u6ec5\u83cc\u6c34\u3092\u304a\u4f7f\u3044\u304f\u3060\u3055\u3044\u3002\u4f5c\u696d\u5e0c\u91c8\u6db2\u306e\u5438\u7740\u30ed\u30b9\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u308b\u305f\u3081\u3001\u30ad\u30e3\u30ea\u30a2\u30bf\u30f3\u30d1\u30af\u8cea\uff08BSA\u30010.1%\uff09\u306e\u4efb\u610f\u6dfb\u52a0\u3092\u304a\u52e7\u3081\u3057\u307e\u3059\u3002<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u7814\u7a76\u7528\u9014<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u5b9f\u9a13\u5ba4\u7814\u7a76\u7528\u306e\u307f\u3067\u3059\u3002\u30d2\u30c8\u307e\u305f\u306f\u52d5\u7269\u306e\u8a3a\u65ad\u30fb\u6cbb\u7642\u76ee\u7684\u306b\u306f\u4f7f\u7528\u3057\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><!-- \/medsbase-tldr-answer --><\/p>\n<h2>GDF-8\uff08\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\uff09\u3068\u306f\u4f55\u3067\u3059\u304b\uff1f<\/h2>\n<p><strong>GDF-8<\/strong> \uff08Growth\/Differentiation Factor 8\uff09\u306f\u3001\u4e00\u822c\u306b <strong>\u30df\u30aa\u30b9\u30bf\u30c1\u30f3<\/strong>, \u3001\u30c8\u30e9\u30f3\u30b9\u30d5\u30a9\u30fc\u30df\u30f3\u30b0\u6210\u9577\u56e0\u5b50\u03b2\uff08TGF-\u03b2\uff09\u30b9\u30fc\u30d1\u30fc\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u4e00\u54e1\u3067\u3042\u308a\u3001\u9aa8\u683c\u7b4b\u91cf\u306e\u4e3b\u8981\u306a\u751f\u7406\u7684\u8ca0\u306e\u8abf\u7bc0\u56e0\u5b50\u3067\u3059\u30021997\u5e74\u306bMcPherron\u3001Lawler\u3001Lee\uff08Nature 1997\uff09\u306b\u3088\u308a\u5206\u6ccc\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3057\u3066\u521d\u3081\u3066\u7279\u6027\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u3001\u30de\u30a6\u30b9\u3067\u6a19\u7684\u7834\u58ca\u3092\u884c\u3046\u3068\u91ce\u751f\u578b\u5bfe\u7167\u3068\u6bd4\u8f03\u3057\u3066\u9aa8\u683c\u7b4b\u91cf\u304c2\uff5e3\u500d\u306b\u5897\u52a0\u3057\u305f\u52d5\u7269\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u3002\u540c\u3058\u907a\u4f1d\u5b50\u306f\u3059\u3050\u306b\u3001\u30d9\u30eb\u30b8\u30a2\u30f3\u30d6\u30eb\u30fc\u7a2e\u3084\u30d4\u30a8\u30e2\u30f3\u30c6\u7a2e\u306e\u725b\u306b\u304a\u3051\u308b\u300c\u30c0\u30d6\u30eb\u30de\u30c3\u30b9\u30eb\u300d\u8868\u73fe\u578b\u3001\u7af6\u8d70\u7528\u30b0\u30ec\u30a4\u30cf\u30a6\u30f3\u30c9\u306e\u30d6\u30ea\u30fc\u30a6\u30a3\u30da\u30c3\u30c8\u8868\u73fe\u578b\u3001\u305d\u3057\u3066\u8457\u660e\u306a\u4e73\u5150\u671f\u8d85\u7b4b\u80a5\u5927\u3092\u5448\u3057\u305f1\u4f8b\u306e\u30d2\u30c8\u75c7\u4f8b\uff08Schuelke\u3089\u3001NEJM 2004\uff09\u306e\u539f\u56e0\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u307e\u3057\u305f \u2014 \u3053\u308c\u3089\u306f\u3044\u305a\u308c\u3082\u6a5f\u80fd\u55aa\u5931\u578bMSTN\u5909\u7570\u3092\u6709\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>\u6210\u719f\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u306f\u3001375\u30a2\u30df\u30ce\u9178\u306e\u30d7\u30ec\u30d7\u30ed\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7ffb\u8a33\u5f8c\u30d7\u30ed\u30bb\u30b7\u30f3\u30b0\u306b\u3088\u308a\u751f\u6210\u3055\u308c\u307e\u3059\uff1a\u5206\u6ccc\u4e2d\u306b\u30b7\u30b0\u30ca\u30eb\u30da\u30d7\u30c1\u30c9\u304c\u9664\u53bb\u3055\u308c\u3001\u6b21\u306b\u30d7\u30ed\u30c9\u30e1\u30a4\u30f3\uff08\u7d04243\u30a2\u30df\u30ce\u9178\uff09\u304c\u30d5\u30ea\u30f3\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u306b\u3088\u308a\u5207\u65ad\u3055\u308c\u3066\u3001\u6d3b\u6027\u578b\u306e109\u30a2\u30df\u30ce\u9178\u306eC\u672b\u7aef\u6210\u719f\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u304c\u653e\u51fa\u3055\u308c\u307e\u3059\u3002\u6d3b\u6027\u578b\u306f\u30012\u3064\u306e\u6210\u719f\u30e2\u30ce\u30de\u30fc\u9396\u304c\u5206\u5b50\u9593\u30b8\u30b9\u30eb\u30d5\u30a3\u30c9\u7d50\u5408\u306b\u3088\u308a\u5171\u6709\u7d50\u5408\u3057\u305f\u30db\u30e2\u30c0\u30a4\u30de\u30fc\u3067\u3001\u975e\u9084\u5143SDS-PAGE\u3067\u306e\u898b\u304b\u3051\u306e\u8cea\u91cf\u306f\u7d0425.8 kDa\u3067\u3059\u3002\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u6a19\u6e96\u7684\u306aTGF-\u03b2\u30b7\u30b9\u30c1\u30f3\u30ce\u30c3\u30c8\u30d5\u30a9\u30fc\u30eb\u30c9\u3092\u63a1\u7528\u3057\u3001\u30a2\u30af\u30c1\u30d3\u30f3IIB\u578b\u53d7\u5bb9\u4f53\uff08ActRIIB\uff09\u306b\u9ad8\u89aa\u548c\u6027\u3067\u7d50\u5408\u3057\u3066Smad\u4ecb\u5728\u6027\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u958b\u59cb\u3057\u307e\u3059\u3002\u7d44\u63db\u3048\u578bGDF-8\u306f\u3001\u9759\u83cc\u6c34\u3067\u6eb6\u89e3\u3059\u308b\u305f\u3081\u306e\u9ad8\u7d14\u5ea6\u51cd\u7d50\u4e7e\u71e5\u7c89\u672b\u3068\u3057\u3066\u4f9b\u7d66\u3055\u308c\u307e\u3059\u3002\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u306f <strong>\u627f\u8a8d\u3055\u308c\u3066\u3044\u307e\u305b\u3093<\/strong> FDA\u3001EMA\u3001MHRA\u3001\u305d\u306e\u4ed6\u306e\u4e3b\u8981\u898f\u5236\u6a5f\u95a2\u306b\u3088\u308a\u30d2\u30c8\u6cbb\u7642\u7528\u3068\u3057\u3066\u3002\u3053\u3061\u3089\u3067\u8ca9\u58f2\u3055\u308c\u3066\u3044\u308b\u7814\u7a76\u7528\u30b0\u30ec\u30fc\u30c9\u306eGDF-8\u306f\u3001 <strong>\u7814\u7a76\u5ba4\u7814\u7a76\u7528\u306e\u307f\u3067\u3059<\/strong> \u30d2\u30c8\u307e\u305f\u306f\u52d5\u7269\u3078\u306e\u6295\u4e0e\u3092\u76ee\u7684\u3068\u3057\u305f\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<h2>\u4f5c\u7528\u6a5f\u5e8f \u2014 ActRIIB\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3068Smad2\/Smad3\u7d4c\u8def<\/h2>\n<p>GDF-8\u304cTGF-\u03b2\u30b9\u30fc\u30d1\u30fc\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u30ea\u30ac\u30f3\u30c9\u306e\u4e2d\u3067\u6a5f\u69cb\u7684\u306b\u969b\u7acb\u3063\u3066\u3044\u308b\u70b9\u306f\u3001\u305d\u306e <strong>\u7b4b\u8089\u6210\u9577\u3092\u6301\u7d9a\u7684\u306b\u6291\u5236\u3059\u308b\u4e3b\u8981\u306a\u5f79\u5272<\/strong> \u516c\u8868\u3055\u308c\u305f\u7814\u7a76\u3067\u5b9f\u8a3c\u3055\u308c\u305f\u3001\u3088\u304f\u7279\u5fb4\u4ed8\u3051\u3089\u308c\u305f3\u6bb5\u968e\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30ab\u30b9\u30b1\u30fc\u30c9\u3092\u901a\u3058\u3066\uff1a<\/p>\n<ul>\n<li><strong>ActRIIB\u53d7\u5bb9\u4f53\u7d50\u5408\u3068I\u578b\u53d7\u5bb9\u4f53\u306e\u30ea\u30af\u30eb\u30fc\u30c8<\/strong> \u2014 \u6210\u719f\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u30db\u30e2\u4e8c\u91cf\u4f53\u306f\u3001\u9aa8\u683c\u7b4b\u7dda\u7dad\u304a\u3088\u3073\u4ed6\u306e\u7d30\u80de\u7a2e\u306e\u8868\u9762\u306b\u3042\u308b\u30a2\u30af\u30c1\u30d3\u30f3IIB\u578b\u53d7\u5bb9\u4f53\uff08ActRIIB\uff09\u306b\u7d50\u5408\u3057\u307e\u3059\u3002ActRIIB\u306f\u6052\u5e38\u7684\u306b\u6d3b\u6027\u5316\u3057\u3066\u3044\u308b\u30bb\u30ea\u30f3\/\u30b9\u30ec\u30aa\u30cb\u30f3\u30ad\u30ca\u30fc\u30bc\u3067\u3042\u308a\u3001\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u304c\u7d50\u5408\u3059\u308b\u3068\u3001I\u578b\u53d7\u5bb9\u4f53ALK4\uff08ActRIB\uff09\u304a\u3088\u3073ALK5\uff08T\u03b2RI\uff09\u3092\u30ea\u30af\u30eb\u30fc\u30c8\u3057\u3001\u30c8\u30e9\u30f3\u30b9\u30ea\u30f3\u9178\u5316\u3057\u307e\u3059\u3002\u30ea\u30ac\u30f3\u30c9-\u53d7\u5bb9\u4f53\u306e\u5316\u5b66\u91cf\u8ad6\u306f\u3001\u6d3b\u6027\u8907\u5408\u4f53\u306b\u304a\u3044\u30662:2:2\u306e\u30d8\u30c6\u30ed\u56db\u91cf\u4f53\u3067\u3059\u3002ActRIIB\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u306f\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u3068\u985e\u4f3c\u3057\u305f\u8868\u73fe\u578b\u3092\u793a\u3057\u3001\u53d7\u5bb9\u4f53\u306e\u540c\u4e00\u6027\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<li><strong>Smad2\/Smad3\u306e\u30ea\u30f3\u9178\u5316\u3068\u6838\u79fb\u884c<\/strong> \u2014 \u30ea\u30f3\u9178\u5316\u3055\u308c\u305fALK4\/ALK5 I\u578b\u53d7\u5bb9\u4f53\u306f\u3001\u53d7\u5bb9\u4f53\u5236\u5fa1\u578bSmad\u3001\u7279\u306b\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u7d4c\u8def\u306eSmad2\u304a\u3088\u3073Smad3\u3092\u30ea\u30f3\u9178\u5316\u3057\u307e\u3059\u3002\u30ea\u30f3\u9178\u5316Smad2\/Smad3\u306fSmad4\uff08\u5171\u901a\u306eSmad\uff09\u3068\u30d8\u30c6\u30ed\u30de\u30fc\u8907\u5408\u4f53\u3092\u5f62\u6210\u3057\u3066\u6838\u5185\u3078\u79fb\u884c\u3057\u3001\u6a19\u7684\u907a\u4f1d\u5b50\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306eSmad\u7d50\u5408\u30a8\u30ec\u30e1\u30f3\u30c8\u306b\u7d50\u5408\u3057\u3066\u8ee2\u5199\u30b3\u30d5\u30a1\u30af\u30bf\u30fc\u3092\u30ea\u30af\u30eb\u30fc\u30c8\u3057\u307e\u3059\u3002Smad\u7d4c\u8def\u306f\u9aa8\u683c\u7b4b\u306b\u304a\u3051\u308b\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u306e\u4e3b\u8981\u306a\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u51fa\u529b\u3067\u3059\u3002<\/li>\n<li><strong>\u4e0b\u6d41\u306e\u8ee2\u5199\u52b9\u679c \u2014 \u30a2\u30c8\u30ed\u30b8\u30f3-1\/MuRF1\u306e\u4e0a\u65b9\u5236\u5fa1\u3068\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u6291\u5236<\/strong> \u2014 \u6838\u5185\u306eSmad\u8907\u5408\u4f53\u306f\u3001\u4ee5\u4e0b\u306e3\u3064\u306e\u53ce\u675f\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u901a\u3058\u3066\u7b4b\u840e\u7e2e\u3092\u4fc3\u9032\u3059\u308b\u8ee2\u5199\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u8abf\u6574\u3057\u307e\u3059\uff1a\u30e6\u30d3\u30ad\u30c1\u30f3\u30ea\u30ac\u30fc\u30bc\u840e\u7e2e\u907a\u4f1d\u5b50\uff08\u30a2\u30c8\u30ed\u30b8\u30f3-1\/Fbxo32\u304a\u3088\u3073MuRF1\/Trim63\uff09\u306e\u8a98\u5c0e\u306b\u3088\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u306e\u52a0\u901f\uff1bIGF\/\u30a4\u30f3\u30b9\u30ea\u30f3\u8ef8\u3068\u306e\u30af\u30ed\u30b9\u30c8\u30fc\u30af\u3092\u4ecb\u3057\u305fAkt\/mTOR\u4f9d\u5b58\u6027\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u306e\u963b\u5bb3\uff1b\u7b4b\u539f\u6027\u8abf\u7bc0\u56e0\u5b50\uff08MyoD\u3001\u30df\u30aa\u30b2\u30cb\u30f3\uff09\u306e\u6291\u5236\u306b\u3088\u308b\u885b\u661f\u7d30\u80de\u99c6\u52d5\u578b\u4fee\u5fa9\u306e\u6e1b\u901f\u3002\u7dcf\u5408\u7684\u306a\u52b9\u679c\u3068\u3057\u3066\u3001\u7b4b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u84c4\u7a4d\u304c\u6e1b\u5c11\u3057\u3001\u9ad8\u7528\u91cf\u307e\u305f\u306f\u6162\u6027\u7684\u306a\u66dd\u9732\u3067\u306f\u660e\u3089\u304b\u306a\u840e\u7e2e\u304c\u751f\u3058\u307e\u3059\u3002<\/li>\n<\/ul>\n<p>\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u3053\u3068\u306f\u3001GDF-8\u306f\u751f\u7406\u7684\u6761\u4ef6\u4e0b\u3067\u6301\u7d9a\u7684\u306a\u963b\u5bb3\u56e0\u5b50\u3068\u3057\u3066\u4f5c\u7528\u3057\u3001\u7b4b\u91cf\u306f\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u306e\u7dca\u5f35\uff08\u840e\u7e2e\u6027\uff09\u3068IGF\/Akt\/mTOR\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\uff08\u540c\u5316\u6027\uff09\u306e\u30d0\u30e9\u30f3\u30b9\u306b\u3088\u3063\u3066\u8abf\u7bc0\u3055\u308c\u308b\u3068\u3044\u3046\u70b9\u3067\u3059\u3002\u305d\u306e\u305f\u3081\u3001 <a href=\"https:\/\/medsbase.com\/ja\/follistatin-344\/\">Follistatin 344<\/a> \uff08\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\/\u30a2\u30af\u30c1\u30d3\u30f3\u62ee\u6297\u85ac\uff09\u3068\u7d44\u63db\u3048GDF-8\uff08\u30a2\u30b4\u30cb\u30b9\u30c8\u305d\u306e\u3082\u306e\uff09\u306f\u3001\u3069\u3061\u3089\u3082\u7b4b\u7814\u7a76\u3067\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u62ee\u6297\u85ac\u306f\u30d6\u30ec\u30fc\u30ad\u3092\u53d6\u308a\u9664\u304d\u3001\u4e00\u65b9\u3001\u7d44\u63db\u3048\u30ea\u30ac\u30f3\u30c9\u306f\u30d6\u30ec\u30fc\u30ad\u306e\u5f37\u3055\u3092\u5b9a\u91cf\u5316\u3057\u3001\u53d7\u5bb9\u4f53\u7d50\u5408\u30a2\u30c3\u30bb\u30a4\u3084\u30ec\u30dd\u30fc\u30bf\u30fc\u7d30\u80de\u30a2\u30c3\u30bb\u30a4\u3067\u62ee\u6297\u85ac\u306e\u6d3b\u6027\u3092\u691c\u8a3c\u3059\u308b\u305f\u3081\u306e\u5b9f\u9a13\u30c4\u30fc\u30eb\u3067\u3059\u3002<\/p>\n<h2>\u516c\u8868\u3055\u308c\u305f\u7814\u7a76\u7528\u9014<\/h2>\n<p>\u7d44\u63db\u3048GDF-8\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u7814\u7a76\u76ee\u7684\u306e\u5b9f\u9a13\u5ba4\u7814\u7a76\u3067\u4f7f\u7528\u3055\u308c\u307e\u3059\uff1a<\/p>\n<ul>\n<li><strong>\u7b4b\u840e\u7e2e\u30fb\u6d88\u8017\u306e\u7814\u7a76<\/strong> \u2014 \u30a4\u30f3\u30d3\u30c8\u30ed\u7b4b\u7ba1\u840e\u7e2e\u30a2\u30c3\u30bb\u30a4\u3001\u30a8\u30af\u30b9\u30d3\u30dc\u7b4b\u6a19\u672c\u3001\u4ecb\u5165\u6226\u7565\u7814\u7a76\u306e\u305f\u3081\u306b\u518d\u73fe\u6027\u306e\u3042\u308b\u840e\u7e2e\u8868\u73fe\u578b\u3092\u8a98\u5c0e\u3059\u308b\u30a4\u30f3\u30d3\u30dc\u6295\u4e0e\uff08McPherron et al., Nature 1997; Lee, Annu Rev Cell Dev Biol 2004\uff09<\/li>\n<li><strong>\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u62ee\u6297\u85ac\u306e\u691c\u8a3c<\/strong> \u2014 \u7d50\u5408\u89aa\u548c\u6027\u30a2\u30c3\u30bb\u30a4\u3001\u4e2d\u548c\u6297\u4f53\u529b\u4fa1\u30a2\u30c3\u30bb\u30a4\u3001\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u7d4c\u8def\u3092\u6a19\u7684\u3068\u3059\u308b\u5275\u85ac\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u305f\u3081\u306e\u53d7\u5bb9\u4f53\u5360\u6709\u7387\u30a2\u30c3\u30bb\u30a4\uff1b\u691c\u8a3c\u3059\u308b\u305f\u3081\u306e\u6a19\u6e96\u7684\u306a\u7814\u7a76\u30c4\u30fc\u30eb <a href=\"https:\/\/medsbase.com\/ja\/follistatin-344\/\">follistatin 344<\/a>, \u53ef\u6eb6\u6027ActRIIB-Fc\u878d\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u6297\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u6297\u4f53<\/li>\n<li><strong>Smad2\/Smad3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u7814\u7a76<\/strong> \u2014 Smad\u30ea\u30f3\u9178\u5316\u52d5\u614b\u3001\u6838\u79fb\u884c\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3001Smad\u7d50\u5408\u30a8\u30ec\u30e1\u30f3\u30c8\u30ec\u30dd\u30fc\u30bf\u30fc\u30a2\u30c3\u30bb\u30a4\u3001\u4ed6\u306eTGF-\u03b2\u7d4c\u8def\u30e1\u30f3\u30d0\u30fc\u3068\u306e\u30af\u30ed\u30b9\u30c8\u30fc\u30af<\/li>\n<li><strong>\u30a2\u30c8\u30ed\u30b8\u30fc\u30f3\u8ee2\u5199\u7814\u7a76<\/strong> \u2014 \u30a2\u30c8\u30ed\u30b8\u30f3-1\uff08Fbxo32\uff09\u304a\u3088\u3073MuRF1\uff08Trim63\uff09\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u89e3\u6790\u3001\u30e6\u30d3\u30ad\u30c1\u30f3-\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u6d3b\u6027\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u8ef8\u3068\u306e\u30af\u30ed\u30b9\u30c8\u30fc\u30af<\/li>\n<li><strong>\u60aa\u6db2\u8cea\u304a\u3088\u3073\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u30e2\u30c7\u30eb<\/strong> \u2014 \u816b\u760d\u62c5\u6301\u3052\u3063\u6b6f\u985e\u60aa\u6db2\u8cea\u30e2\u30c7\u30eb\u3001\u8001\u9f62\u30de\u30a6\u30b9\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u3001\u9664\u795e\u7d4c\u8a98\u767a\u6027\u840e\u7e2e \u2014 \u7d44\u63db\u3048GDF-8\u3092\u7528\u3044\u3066\u6d88\u8017\u8868\u73fe\u578b\u3092\u5897\u5e45\u307e\u305f\u306f\u518d\u73fe<\/li>\n<li><strong>\u5fc3\u81d3\u304a\u3088\u3073\u305d\u306e\u4ed6\u306e\u7d44\u7e54\u7814\u7a76<\/strong> \u2014 \u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u306f\u5fc3\u81d3\u3001\u8102\u80aa\u3001\u305d\u306e\u4ed6\u306e\u7d44\u7e54\u3067\u4f4e\u30ec\u30d9\u30eb\u3067\u767a\u73fe\uff1b\u767a\u8868\u3055\u308c\u305f\u7814\u7a76\u3067\u306f\u3001\u5fc3\u7b4b\u7d30\u80de\u80a5\u5927\u30e2\u30c7\u30eb\u304a\u3088\u3073\u8102\u80aa\u7d44\u7e54\u751f\u7269\u5b66\u306b\u304a\u3051\u308bGDF-8\u306e\u5f71\u97ff\u3092\u8abf\u67fb<\/li>\n<li><strong>TGF-\u03b2\u30b9\u30fc\u30d1\u30fc\u30d5\u30a1\u30df\u30ea\u30fc\u6bd4\u8f03\u7814\u7a76<\/strong> \u2014 \u8fd1\u7e01\u306eGDF-11\uff08\u6210\u719f\u30c9\u30e1\u30a4\u30f3\u306790%\u306e\u914d\u5217\u540c\u4e00\u6027\uff09\u304a\u3088\u3073\u30a2\u30af\u30c1\u30d3\u30f3A\uff08\u540c\u3058\u53d7\u5bb9\u4f53\u30b7\u30b9\u30c6\u30e0\u306b\u7d50\u5408\uff09\u3068\u306e\u30d9\u30f3\u30c1\u30de\u30fc\u30ad\u30f3\u30b0\uff1b\u53d7\u5bb9\u4f53\u9078\u629e\u6027\u306e\u6a5f\u69cb\u7684\u89e3\u660e<\/li>\n<li><strong>\u30d5\u30a9\u30ea\u30b9\u30bf\u30c1\u30f3344\u3068\u306e\u9006\u85ac\u7406\u5b66\u7684\u30da\u30a2\u30ea\u30f3\u30b0<\/strong> \u2014 \u3068\u306e\u4f75\u7528\u6295\u4e0e <a href=\"https:\/\/medsbase.com\/ja\/follistatin-344\/\">Follistatin 344<\/a> \u30a2\u30f3\u30bf\u30b4\u30cb\u30b9\u30c8\u30a2\u30fc\u30e0\u3068\u3057\u3066\u3001\u7814\u7a76\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\/\u30a2\u30f3\u30bf\u30b4\u30cb\u30b9\u30c8\u7d50\u5408\u306e\u5316\u5b66\u91cf\u8ad6\u306e\u76f4\u63a5\u5b9a\u91cf\u3068GDF-8\u8a98\u767a\u6027\u840e\u7e2e\u306e\u30ec\u30b9\u30ad\u30e5\u30fc\u3092\u53ef\u80fd\u306b\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n<p>GDF-8\u304c\u540c\u5316\u4f5c\u7528\/\u7b4b\u8089\u7814\u7a76\u306e\u5c55\u671b\u306e\u4e2d\u3067\u3069\u306e\u3088\u3046\u306a\u4f4d\u7f6e\u3092\u5360\u3081\u308b\u304b\u306b\u3064\u3044\u3066\u306e\u3088\u308a\u5e83\u7bc4\u306a\u6587\u8108\u306b\u3064\u3044\u3066\u306f\u3001\u4ee5\u4e0b\u3092\u53c2\u7167\u3057\u3066\u304f\u3060\u3055\u3044 <a href=\"https:\/\/medsbase.com\/ja\/follistatin-344\/\">Follistatin 344<\/a> \u6a19\u6e96\u7684\u306a\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u62ee\u6297\u85ac\u3068\u3057\u3066\u3001, <a href=\"https:\/\/medsbase.com\/ja\/igf-1-lr3\/\">IGF-1 LR3<\/a> \u53cd\u5bfe\u7d4c\u8def\u306e\u540c\u5316\u4f5c\u7528\u90e8\u9580\uff08\u76f4\u63a5\u7684\u306aIGF-1R\u4f5c\u52d5\uff09\u306e\u305f\u3081\u306b\u3001\u305d\u3057\u3066 <a href=\"https:\/\/medsbase.com\/ja\/tb-500\/\">TB-500<\/a> \u5168\u8eab\u306e\u7b4b\u8089\u304a\u3088\u3073\u7d44\u7e54\u306e\u56de\u5fa9\u7814\u7a76\u306e\u305f\u3081\u306b\u3002\u3059\u3079\u3066\u306e <a href=\"https:\/\/medsbase.com\/ja\/peptides\/\">\u7814\u7a76\u7528\u30da\u30d7\u30c1\u30c9\u30ab\u30bf\u30ed\u30b0<\/a> \u5316\u5408\u7269\u9078\u629e\u306e\u305f\u3081\u306b\u3002<\/p>\n<h2>\u5229\u7528\u53ef\u80fd\u306a\u529b\u4fa1\u3068\u6fc3\u5ea6<\/h2>\n<p>MedsBase\u3067\u306f\u30011 mg\u306e\u51cd\u7d50\u4e7e\u71e5\u30d0\u30a4\u30a2\u30eb\u5165\u308a\u7d44\u63db\u3048GDF-8\uff08Myostatin\uff09\u3092\u5728\u5eab\u3057\u3066\u304a\u308a\u307e\u3059\u3002\u3053\u306e\u30d0\u30a4\u30a2\u30eb\u306f\u300110\u672c\u5165\u308a\u307e\u305f\u306f20\u672c\u5165\u308a\u306e\u30d1\u30c3\u30af\u5f62\u5f0f\u3067\u3001\u5b8c\u5168\u306a\u518d\u6eb6\u89e3\u30ac\u30a4\u30c0\u30f3\u30b9\u4ed8\u304d\u3067\u3054\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\uff1a<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u30d0\u30a4\u30a2\u30eb\u529b\u4fa1<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u5178\u578b\u7684\u306a\u7814\u7a76\u4f7f\u7528\u4f8b<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u30d1\u30c3\u30af\u30b5\u30a4\u30ba<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>1 mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u6a19\u6e96\u7814\u7a76\u5f37\u5ea6 \u2014 \u7d50\u5408\u30a2\u30c3\u30bb\u30a4\u3001\u840e\u7e2e\u8a98\u5c0e\u30d7\u30ed\u30c8\u30b3\u30eb\u3001\u62ee\u6297\u85ac\u30d0\u30ea\u30c7\u30fc\u30b7\u30e7\u30f3<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10\u307e\u305f\u306f20\u30d0\u30a4\u30a2\u30eb<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>GDF-8\u306f\u3001\u7d0425.8 kDa\u306e\u7d44\u63db\u3048\u30db\u30e2\u4e8c\u91cf\u4f53\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3001HPLC\u7d14\u5ea695%\u4ee5\u4e0a\u3067\u4f9b\u7d66\u3055\u308c\u307e\u3059\u30021 mg\u30d0\u30a4\u30a2\u30eb\u5f62\u5f0f\u306f\u3001\u5178\u578b\u7684\u306a\u7814\u7a76\u7528\u91cf\u7bc4\u56f2\u3092\u30ab\u30d0\u30fc\u3057\u307e\u3059\uff1ain vitro\u7d50\u5408\u30a2\u30c3\u30bb\u30a4\u3084\u30ec\u30dd\u30fc\u30bf\u30fc\u7d30\u80de\u30a2\u30c3\u30bb\u30a4\u3067\u306e\u30ca\u30ce\u30e2\u30eb\u6fc3\u5ea6\u306e\u4f5c\u696d\u6fc3\u5ea6\u3067\u306f\u3001\u30d0\u30a4\u30a2\u30eb\u306e\u3054\u304f\u4e00\u90e8\u3092\u6d88\u8cbb\u3057\u307e\u3059\uff1b\u3052\u3063\u6b6f\u985e\u30e2\u30c7\u30eb\u3067\u306ein vivo\u6295\u4e0e\u3067\u306f\u3001\u6ce8\u5c04\u3042\u305f\u308a\u30de\u30a4\u30af\u30ed\u30b0\u30e9\u30e0\u5358\u4f4d\u306e\u7528\u91cf\u3092\u4f7f\u7528\u3057\u3001\u30d7\u30ed\u30c8\u30b3\u30eb\u3042\u305f\u308a\u306e\u30d0\u30a4\u30a2\u30eb\u6d88\u8cbb\u91cf\u304c\u591a\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n<h2>\u6bd4\u8f03 \u2014 GDF-8\uff08Myostatin\uff09 vs Follistatin 344<\/h2>\n<p>\u7d44\u63db\u3048GDF-8\u304a\u3088\u3073 <a href=\"https:\/\/medsbase.com\/ja\/follistatin-344\/\">Follistatin 344<\/a> \u306f\u9006\u85ac\u7406\u5b66\u306e\u30da\u30a2\u3067\u3059\uff1aGDF-8\u306f\u30ea\u30ac\u30f3\u30c9\u3067\u3042\u308a\u3001Follistatin 344\u306f\u305d\u308c\u3092\u9694\u96e2\u3059\u308b\u9ad8\u89aa\u548c\u6027\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u3002\u3053\u308c\u3089\u306f\u3001\u62ee\u6297\u85ac\u306e\u6a5f\u80fd\u304c\u30ea\u30ac\u30f3\u30c9\u306b\u5bfe\u3057\u3066\u306e\u307f\u5b9a\u91cf\u5316\u3067\u304d\u308b\u305f\u3081\u3001\u7814\u7a76\u3067\u65e5\u5e38\u7684\u306b\u30da\u30a2\u3067\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u95a2\u4fc2\u306f\u3001\u85ac\u7406\u5b66\u306b\u304a\u3051\u308b\u4ed6\u306e\u3088\u304f\u77e5\u3089\u308c\u305f\u9006\u306e\u30da\u30a2\uff08\u4f8b\uff1a\u540c\u3058\u53d7\u5bb9\u4f53\u306e\u4f5c\u52d5\u85ac\uff0b\u62ee\u6297\u85ac\uff09\u3068\u985e\u4f3c\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u53d7\u5bb9\u4f53\u30ec\u30d9\u30eb\u3067\u306f\u306a\u304f\u30ea\u30ac\u30f3\u30c9-\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u30ec\u30d9\u30eb\u3067\u306e\u3082\u306e\u3067\u3059\u3002<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u8a55\u4fa1\u9805\u76ee<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">GDF-8 (Myostatin)<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Follistatin 344<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u7b4b\u8089\u751f\u7269\u5b66\u306b\u304a\u3051\u308b\u5f79\u5272<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u840e\u7e2e\u6027\u30ea\u30ac\u30f3\u30c9\uff08\u30d6\u30ec\u30fc\u30ad\uff09<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u30a2\u30f3\u30bf\u30b4\u30cb\u30b9\u30c8\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u30d6\u30ec\u30fc\u30ad\u9664\u53bb\u5264\uff09<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u6d3b\u6027\u578b<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">109\u30a2\u30df\u30ce\u9178\u30db\u30e2\u4e8c\u91cf\u4f53\uff08\u7d0425.8 kDa\uff09<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">344\u30a2\u30df\u30ce\u9178\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u5358\u91cf\u4f53\uff08\u7d0437 kDa\uff09<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u53d7\u5bb9\u4f53\u307e\u305f\u306f\u6a19\u7684<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">ActRIIB\uff08\u30a2\u30af\u30c1\u30d3\u30f3IIB\u578b\u53d7\u5bb9\u4f53\uff09<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\/\u30a2\u30af\u30c1\u30d3\u30f3\u3092\u9694\u96e2\uff08\u53d7\u5bb9\u4f53\u306a\u3057\uff1b\u76f4\u63a5\u30ea\u30ac\u30f3\u30c9\u7d50\u5408\uff09<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u4e0b\u6d41\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Smad2\/Smad3\u3001\u840e\u7e2e\u907a\u4f1d\u5b50\u3092\u6d3b\u6027\u5316<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u30ea\u30ac\u30f3\u30c9\u9664\u53bb\u306b\u3088\u308aSmad\u6d3b\u6027\u5316\u3092\u963b\u5bb3<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u4e3b\u306a\u7814\u7a76\u7528\u9014<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u840e\u7e2e\u8868\u73fe\u578b\u3092\u8a98\u5c0e\/\u63a2\u7d22\u3059\u308b\u30c4\u30fc\u30eb<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u840e\u7e2e\u3092\u56de\u5fa9\/\u4e88\u9632\u3059\u308b\u30c4\u30fc\u30eb<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u4e00\u822c\u7684\u306a\u7814\u7a76\u7528\u91cf<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10\uff5e100 ng\/mL\uff08in vitro\uff09\uff1b0.1\uff5e10 mcg\uff08in vivo\uff09<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10\uff5e100 mcg \u30a4\u30f3\u30d3\u30dc 1\u56de\u3042\u305f\u308a<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u4f75\u7528<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u7d50\u5408\u5316\u5b66\u91cf\u8ad6\u306e\u305f\u3081\u306e\u30d5\u30a9\u30ea\u30b9\u30bf\u30c1\u30f3344\u3068\u306e\u4f75\u7528<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u62ee\u6297\u6d3b\u6027\u3092\u691c\u8a3c\u3059\u308b\u305f\u3081\u306eGDF-8\u3068\u306e\u4f75\u7528<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u7b4b\u8089\u7814\u7a76\u306e\u8a2d\u8a08\u306b\u304a\u3044\u3066\u3001\u3053\u306e\u30da\u30a2\u306f\u4e3b\u306b3\u3064\u306e\u65b9\u6cd5\u3067\u4f75\u7528\u3055\u308c\u307e\u3059\uff1a(1) \u30d5\u30a9\u30ea\u30b9\u30bf\u30c1\u30f3\u2013\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u76f8\u4e92\u4f5c\u7528\u306e\u7d50\u5408\u89aa\u548c\u6027\u6e2c\u5b9a\uff08\u8868\u9762\u30d7\u30e9\u30ba\u30e2\u30f3\u5171\u9cf4\u3001ELISA\u3001\u7b49\u6e29\u6ef4\u5b9a\u71b1\u91cf\u6e2c\u5b9a\uff09\u3001(2) GDF-8\u304c\u7b4b\u7ba1\u840e\u7e2e\u3092\u8a98\u5c0e\u3057\u3001\u30d5\u30a9\u30ea\u30b9\u30bf\u30c1\u30f3\u306e\u4f75\u7528\u51e6\u7406\u304c\u30ec\u30b9\u30ad\u30e5\u30fc\u52b9\u679c\u3092\u691c\u8a3c\u3055\u308c\u308b\u7d30\u80de\u30d9\u30fc\u30b9\u306e\u840e\u7e2e\/\u30ec\u30b9\u30ad\u30e5\u30fc\u30a2\u30c3\u30bb\u30a4\u3001(3) GDF-8\u304c\u6d88\u8017\u6027\u8868\u73fe\u578b\u3092\u5897\u5e45\u3057\u3001\u30d5\u30a9\u30ea\u30b9\u30bf\u30c1\u30f3\u306e\u4f75\u7528\u6295\u4e0e\u304c\u305d\u308c\u3092\u6e1b\u5f31\u3055\u305b\u308b\u30a4\u30f3\u30d3\u30dc\u691c\u8a3c\u3002\u3053\u308c\u30892\u3064\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u6a5f\u69cb\u7684\u306b\u76f8\u88dc\u7684\u3067\u3042\u308a\u3001\u5358\u72ec\u3067\u7814\u7a76\u3055\u308c\u308b\u3053\u3068\u306f\u7a00\u3067\u3059\u3002<\/p>\n<h2>\u4fdd\u7ba1\u65b9\u6cd5\u3068\u518d\u6eb6\u89e3<\/h2>\n<p><strong>\u518d\u6eb6\u89e3\u524d\uff1a<\/strong> \u77ed\u671f\u4f7f\u7528\u306e\u30ef\u30fc\u30ad\u30f3\u30b0\u30b9\u30c8\u30c3\u30af\u3068\u3057\u3066\u3001\u51cd\u7d50\u4e7e\u71e5\u30d0\u30a4\u30a2\u30eb\u306f\u5143\u306e\u5305\u88c5\u306e\u307e\u307e2\uff5e8\u00b0C\u3067\u51b7\u8535\u4fdd\u5b58\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u672a\u958b\u5c01\u306e\u9577\u671f\u4fdd\u5b58\u306e\u5834\u5408\u306f\u3001\u221220\u00b0C\u3067\u51cd\u7d50\u4fdd\u5b58\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u51cd\u7d50\u4e7e\u71e5GDF-8\u306f\u51b7\u8535\u3067\u6700\u957712\u30f6\u6708\u3001\u221220\u00b0C\u3067\u6700\u957724\u30f6\u6708\u5b89\u5b9a\u3067\u3059\u3002\u3053\u308c\u306f\u3001\u5927\u578b\u306e\u7d44\u63db\u3048\u30b8\u30b9\u30eb\u30d5\u30a3\u30c9\u7d50\u5408\u4e8c\u91cf\u4f53\u304c\u6642\u9593\u7d4c\u904e\u3068\u3068\u3082\u306b\u30df\u30b9\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u3084\u51dd\u96c6\u3092\u8d77\u3053\u3057\u3084\u3059\u3044\u305f\u3081\u3001\u4f4e\u5206\u5b50\u5408\u6210\u30da\u30d7\u30c1\u30c9\u3088\u308a\u3082\u3084\u3084\u77ed\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u51cd\u7d50\u4e7e\u71e5\u7c89\u672b\u306e\u51cd\u7d50\u878d\u89e3\u30b5\u30a4\u30af\u30eb\u306f\u907f\u3051\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<p><strong>\u518d\u6eb6\u89e3\u624b\u9806\uff1a<\/strong> \u30d0\u30a4\u30a2\u30eb\u306e\u5074\u58c1\u306b\u6cbf\u3063\u3066\u9759\u83cc\u6c34\u3092\u6ce8\u5165\u3057\u3066\u304f\u3060\u3055\u3044\uff08\u51cd\u7d50\u4e7e\u71e5\u30b1\u30fc\u30ad\u306b\u76f4\u63a5\u304b\u3051\u306a\u3044\u3067\u304f\u3060\u3055\u3044\uff09\u30021 mg\u30d0\u30a4\u30a2\u30eb\u306e\u5834\u5408\u30011.0 mL\u306e\u9759\u83cc\u6c34\u30671 mg\/mL\u306e\u4f5c\u696d\u6fc3\u5ea6\u304c\u5f97\u3089\u308c\u307e\u3059\u3002\u9759\u304b\u306b\u65cb\u56de\u3055\u305b\u3066\u304f\u3060\u3055\u3044 \u2014 \u7d76\u5bfe\u306b <strong>\u3057\u307e\u305b\u3093<\/strong> \u632f\u3068\u3046 \u2014 \u305d\u3057\u3066\u5b8c\u5168\u306b\u6eb6\u89e3\u3059\u308b\u307e\u30675\uff5e10\u5206\u9593\u9759\u7f6e\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u7d44\u63db\u3048\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u4f4e\u5206\u5b50\u30da\u30d7\u30c1\u30c9\u3088\u308a\u3082\u6eb6\u89e3\u304c\u9045\u3044\u305f\u3081\u3001\u6fc0\u3057\u3044\u64b9\u62cc\u306f\u5206\u5b50\u9593\u30b8\u30b9\u30eb\u30d5\u30a3\u30c9\u7d50\u5408\u3092\u7834\u58ca\u3057\u3001\u6d3b\u6027\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u6b63\u3057\u304f\u518d\u69cb\u6210\u3055\u308c\u305f\u6eb6\u6db2\u306f\u3001\u900f\u660e\u3067\u7121\u8272\u3067\u3042\u308a\u3001\u76ee\u306b\u898b\u3048\u308b\u7c92\u5b50\u304c\u306a\u3044\u306f\u305a\u3067\u3059\u3002100 mcg\/mL\u672a\u6e80\u306e\u4f5c\u696d\u5e0c\u91c8\u6db2\u306e\u5834\u5408\u3001\u30ad\u30e3\u30ea\u30a2\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u6700\u7d42\u6fc3\u5ea60.1%\u306eBSA\uff09\u3092\u6dfb\u52a0\u3059\u308b\u3053\u3068\u3067\u3001\u30d7\u30e9\u30b9\u30c1\u30c3\u30af\u3084\u30ac\u30e9\u30b9\u8868\u9762\u3078\u306e\u5438\u7740\u640d\u5931\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<p><strong>\u5b8c\u5168\u306b\u518d\u6eb6\u89e3\u3057\u305f\u6eb6\u6db2\u306f\u3001\u7121\u8272\u900f\u660e\u3067\u3042\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/strong> \u6700\u9069\u306a\u5b89\u5b9a\u6027\u3092\u5f97\u308b\u305f\u3081\u30012\uff5e8\u00b0C\u3067\u51b7\u8535\u4fdd\u5b58\u3057\u300130\u65e5\u4ee5\u5185\u306b\u4f7f\u7528\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u518d\u69cb\u6210\u6eb6\u6db2\u306f\u51cd\u7d50\u3057\u306a\u3044\u3067\u304f\u3060\u3055\u3044 \u2014 \u7d44\u63db\u3048\u4e8c\u91cf\u4f53\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u51cd\u7d50\u878d\u89e3\u5909\u6027\u306b\u7279\u306b\u654f\u611f\u3067\u3001\u51dd\u96c6\u3084\u53d7\u5bb9\u4f53\u7d50\u5408\u6d3b\u6027\u306e\u4f4e\u4e0b\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u6fc1\u308a\u3001\u6c88\u6bbf\u3001\u307e\u305f\u306f\u5909\u8272\u304c\u898b\u3089\u308c\u308b\u30d0\u30a4\u30a2\u30eb\u306f\u5ec3\u68c4\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u53b3\u5bc6\u306a\u7528\u91cf\u53cd\u5fdc\u8f03\u6b63\u304c\u5fc5\u8981\u306a\u7d50\u5408\u89aa\u548c\u6027\u30a2\u30c3\u30bb\u30a4\u3067\u306f\u3001\u6700\u3082\u518d\u73fe\u6027\u306e\u9ad8\u3044\u7d50\u679c\u3092\u5f97\u308b\u305f\u3081\u306b\u3001\u518d\u69cb\u6210\u5f8c7\u65e5\u4ee5\u5185\u306e\u65b0\u9bae\u306a\u6eb6\u6db2\u3092\u4f7f\u7528\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<h2 id=\"faqs\">\u3088\u304f\u3042\u308b\u8cea\u554f<\/h2>\n<h3>GDF-8\uff08\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\uff09\u306f\u7814\u7a76\u3067\u4f55\u306b\u4f7f\u7528\u3055\u308c\u307e\u3059\u304b\uff1f<\/h3>\n<p>\u7d44\u63db\u3048GDF-8\u306f\u3001\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u7d4c\u8def\u306e\u6a19\u6e96\u7684\u30a2\u30b4\u30cb\u30b9\u30c8\u3068\u3057\u3066\u57fa\u790e\u7814\u7a76\u3067\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002\u518d\u73fe\u6027\u306e\u3042\u308b\u7b4b\u840e\u7e2e\u8868\u73fe\u578b\u306e\u8a98\u5c0e\u3001Smad2\/Smad3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u7279\u6027\u89e3\u6790\u3001\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u62ee\u6297\u85ac\uff08\u4ee5\u4e0b\u3092\u542b\u3080 <a href=\"https:\/\/medsbase.com\/ja\/follistatin-344\/\">Follistatin 344<\/a> \u304a\u3088\u3073ActRIIB-Fc\u878d\u5408\u30bf\u30f3\u30d1\u30af\u8cea\uff09\u306e\u691c\u8a3c\u3001\u306a\u3089\u3073\u306b\u85ac\u7406\u5b66\u7684\u30a2\u30c3\u30bb\u30a4\u306b\u304a\u3051\u308b\u7d50\u5408\u5316\u5b66\u91cf\u8ad6\u306e\u5b9a\u91cf\u5316\u306e\u305f\u3081\u306e\u5b9f\u9a13\u30c4\u30fc\u30eb\u3067\u3059\u3002\u7814\u7a76\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u4f55\u304b\u3092\u300c\u6539\u5584\u300d\u3059\u308b\u305f\u3081\u306b\u4f7f\u7528\u3055\u308c\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u7814\u7a76\u8005\u304c\u7406\u89e3\u3057\u3001\u6700\u7d42\u7684\u306b\u963b\u5bb3\u3057\u305f\u3044\u3068\u8003\u3048\u308b\u8ca0\u306e\u5236\u5fa1\u56e0\u5b50\u3067\u3059\u3002\u3053\u3061\u3089\u3067\u8ca9\u58f2\u3055\u308c\u3066\u3044\u308b\u7814\u7a76\u7528\u30b0\u30ec\u30fc\u30c9\u306eGDF-8\u306f <strong>\u3057\u307e\u305b\u3093<\/strong> FDA\u627f\u8a8d\u6e08\u307f\u3067\u3042\u308a\u3001\u5b9f\u9a13\u5ba4\u7814\u7a76\u7528\u9014\u306b\u9650\u308a\u53b3\u683c\u306b\u4f9b\u7d66\u3055\u308c\u307e\u3059\u3002<\/p>\n<h3>GDF-8\u306f\u30d5\u30a9\u30ea\u30b9\u30bf\u30c1\u30f3344\u3068\u3069\u3046\u9055\u3044\u307e\u3059\u304b\uff1f<\/h3>\n<p>\u4e21\u8005\u306f\u9006\u306e\u85ac\u7406\u5b66\u7684\u30da\u30a2\u3067\u3059\u3002GDF-8\u306f\u6d3b\u6027\u578b\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u30ea\u30ac\u30f3\u30c9\u3067\u3042\u308a\u3001Smad2\/Smad3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u4ecb\u3057\u3066\u7b4b\u840e\u7e2e\u3092\u4fc3\u9032\u3059\u308b\u3001\u7b4b\u6210\u9577\u3078\u306e\u30d6\u30ec\u30fc\u30ad\u3067\u3059\u3002\u30d5\u30a9\u30ea\u30b9\u30bf\u30c1\u30f3344\u306f\u3001GDF-8\u304a\u3088\u3073\u30a2\u30af\u30c1\u30d3\u30f3\u306b\u9ad8\u3044\u89aa\u548c\u6027\u3067\u7d50\u5408\u3057\u3066\u9694\u96e2\u3057\u3001\u53d7\u5bb9\u4f53\u3078\u306e\u5229\u7528\u53ef\u80fd\u6027\u3092\u596a\u3046\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u3002\u7814\u7a76\u30e2\u30c7\u30eb\u3067\u306f\u3001GDF-8\u304c\u840e\u7e2e\u8868\u73fe\u578b\u3092\u8a98\u5c0e\u307e\u305f\u306f\u5897\u5e45\u3057\u3001\u30d5\u30a9\u30ea\u30b9\u30bf\u30c1\u30f3344\u304c\u305d\u308c\u3092\u6551\u6e08\u3057\u307e\u3059\u3002\u3053\u306e2\u3064\u306f\u3001\u7d50\u5408\u89aa\u548c\u6027\u30a2\u30c3\u30bb\u30a4\u3001\u7d30\u80de\u30d9\u30fc\u30b9\u306e\u6551\u6e08\u30a2\u30c3\u30bb\u30a4\u3001\u304a\u3088\u3073\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u7d4c\u8def\u62ee\u6297\u85ac\u306e\u751f\u4f53\u5185\u691c\u8a3c\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u65e5\u5e38\u7684\u306b\u7d44\u307f\u5408\u308f\u305b\u3066\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002<\/p>\n<h3>GDF-8\u306fGDF-11\u3068\u3069\u3046\u9055\u3044\u307e\u3059\u304b\uff1f<\/h3>\n<p>GDF-8\uff08\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\uff09\u3068GDF-11\u306f\u3001\u6210\u719f\u30c9\u30e1\u30a4\u30f3\u306b\u304a\u3044\u3066\u7d0490%\u306e\u30a2\u30df\u30ce\u9178\u540c\u4e00\u6027\u3092\u5171\u6709\u3057\u3001\u540c\u3058ActRIIB\u53d7\u5bb9\u4f53\u306b\u540c\u7b49\u306e\u89aa\u548c\u6027\u3067\u7d50\u5408\u3057\u307e\u3059\u3002\u6a5f\u80fd\u7684\u5f79\u5272\u306f\u90e8\u5206\u7684\u306b\u91cd\u8907\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u7d44\u7e54\u5206\u5e03\u304c\u7570\u306a\u308a\u307e\u3059\u3002GDF-8\u306f\u4e3b\u306b\u9aa8\u683c\u7b4b\u3067\u767a\u73fe\u3057\u3001\u7b4b\u8089\u91cf\u306e\u4e3b\u8981\u306a\u8abf\u7bc0\u56e0\u5b50\u3067\u3059\u3002GDF-11\u306f\u3088\u308a\u5e83\u7bc4\u306b\u767a\u73fe\u3057\u3001\u5fc3\u81d3\u3001\u795e\u7d4c\u3001\u9020\u8840\u306e\u6587\u8108\u3067\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u914d\u5217\u985e\u4f3c\u6027\u304c\u9ad8\u3044\u305f\u3081\u3001\u9078\u629e\u7684\u306a\u62ee\u6297\u85ac\u306e\u958b\u767a\u304c\u73fe\u5728\u306e\u7814\u7a76\u306e\u4e3b\u8981\u306a\u7126\u70b9\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3>GDF-8\u306e\u4e00\u822c\u7684\u306a\u7814\u7a76\u7528\u91cf\u306f\u3069\u308c\u304f\u3089\u3044\u3067\u3059\u304b\uff1f<\/h3>\n<p>\u516c\u8868\u3055\u308c\u3066\u3044\u308b\u524d\u81e8\u5e8a\u30d7\u30ed\u30c8\u30b3\u30eb\u3067\u306f\u3001\u901a\u5e38\u3001in vitro\u7d30\u80de\u57f9\u990a\u5b9f\u9a13\uff08\u7b4b\u7ba1\u840e\u7e2e\u30a2\u30c3\u30bb\u30a4\u3001\u30ec\u30dd\u30fc\u30bf\u30fc\u7d30\u80de\u30a2\u30c3\u30bb\u30a4\u3001\u7d50\u5408\u7814\u7a76\uff09\u306b\u306f10\uff5e100 ng\/mL\u306e\u4f5c\u696d\u6fc3\u5ea6\u304c\u3001in vivo\u3052\u3063\u6b6f\u985e\u840e\u7e2e\u8a98\u5c0e\u30d7\u30ed\u30c8\u30b3\u30eb\u306b\u306f1\u56de\u306e\u6295\u4e0e\u3042\u305f\u308a0.1\uff5e10 mcg\u304c\u4f7f\u7528\u3055\u308c\u307e\u3059\u30021 mg\u30d0\u30a4\u30a2\u30eb\u30921.0 mL\u306e\u9759\u83cc\u6c34\u3067\u518d\u69cb\u6210\u3059\u308b\u30681 mg\/mL\u3068\u306a\u308a\u3001\u3053\u308c\u3092PBS\u307e\u305f\u306f\u57f9\u5730\u3067\u5e0c\u91c8\u3057\u3066in vitro\u7528\u306e\u30ca\u30ce\u30e2\u30eb\u4f5c\u696d\u6eb6\u6db2\u3092\u8abf\u88fd\u3057\u307e\u3059\u3002<\/p>\n<h3>GDF-8\u306fFDA\u627f\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u304b\uff1f<\/h3>\n<p>\u3044\u3044\u3048\u3002GDF-8\/\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u306f\u3001FDA\u3001EMA\u3001MHRA\u3001\u305d\u306e\u4ed6\u4e3b\u8981\u306a\u898f\u5236\u5f53\u5c40\u306b\u3088\u308b\u30d2\u30c8\u6cbb\u7642\u7528\u9014\u3067\u306e\u627f\u8a8d\u3092\u53d7\u3051\u3066\u3044\u307e\u305b\u3093\u3002\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u7d4c\u8def\u306e\u7814\u7a76\u304b\u3089\u306f\u81e8\u5e8a\u6bb5\u968e\u306e\u62ee\u6297\u85ac\uff08\u6297\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u6297\u4f53\u3001\u53ef\u6eb6\u6027ActRIIB-Fc\u3001\u30d5\u30a9\u30ea\u30b9\u30bf\u30c1\u30f3\u907a\u4f1d\u5b50\u6cbb\u7642\uff09\u304c\u751f\u307e\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u4e00\u90e8\u306f\u7b4b\u30b8\u30b9\u30c8\u30ed\u30d5\u30a3\u30fc\u3084\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u3092\u5bfe\u8c61\u3068\u3057\u305f\u5f8c\u671f\u81e8\u5e8a\u8a66\u9a13\u306b\u9054\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u7d44\u63db\u3048GDF-8\u81ea\u4f53\u306f\u6cbb\u7642\u85ac\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u7814\u7a76\u76ee\u7684\u306e\u307f\u306e\u4f9b\u7d66\u696d\u8005\u306b\u3088\u3063\u3066\u8ca9\u58f2\u3055\u308c\u308b\u3059\u3079\u3066\u306eGDF-8\u306f\u3001\u5b9f\u9a13\u5ba4\u7814\u7a76\u7528\u3067\u3042\u308a\u3001\u30d2\u30c8\u306b\u6295\u4e0e\u3059\u3079\u304d\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<h3>GDF-8\u306f\u3069\u306e\u3088\u3046\u306b\u4fdd\u7ba1\u3059\u3079\u304d\u3067\u3059\u304b\uff1f<\/h3>\n<p>\u51cd\u7d50\u4e7e\u71e5\u30d0\u30a4\u30a2\u30eb\uff1a\u77ed\u671f\u4f5c\u696d\u7528\u30b9\u30c8\u30c3\u30af\u306f2\uff5e8\u00b0C\u3067\u51b7\u8535\u4fdd\u5b58\u3057\u3001\u672a\u958b\u5c01\u30d0\u30a4\u30a2\u30eb\u306e\u9577\u671f\u4fdd\u7ba1\u306f-20\u00b0C\u3067\u4fdd\u5b58\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u518d\u69cb\u6210\u6eb6\u6db2\uff1a2\uff5e8\u00b0C\u3067\u51b7\u8535\u4fdd\u5b58\u3057\u3001\u4e00\u822c\u7684\u306a\u30d7\u30ed\u30c8\u30b3\u30eb\u3067\u306f30\u65e5\u4ee5\u5185\u3001\u53b3\u5bc6\u306a\u6821\u6b63\u304c\u5fc5\u8981\u306a\u7d50\u5408\u89aa\u548c\u6027\u30a2\u30c3\u30bb\u30a4\u3067\u306f7\u65e5\u4ee5\u5185\u306b\u4f7f\u7528\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u518d\u69cb\u6210\u6eb6\u6db2\u3092\u51cd\u7d50\u3057\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002\u7d44\u63db\u3048\u4e8c\u91cf\u4f53\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u7279\u306b\u51cd\u7d50\u878d\u89e3\u306b\u3088\u308b\u5909\u6027\u306b\u5bfe\u3057\u3066\u611f\u53d7\u6027\u304c\u9ad8\u304f\u306a\u308a\u307e\u3059\u3002\u5e38\u306b\u76f4\u5c04\u5149\u304b\u3089\u4fdd\u8b77\u3057\u3066\u304f\u3060\u3055\u3044\u3002100 mcg\/mL\u672a\u6e80\u306e\u4f5c\u696d\u5e0c\u91c8\u6db2\u306b\u306f\u3001\u30ad\u30e3\u30ea\u30a2\u30bf\u30f3\u30d1\u30af\u8cea\uff080.1% BSA\uff09\u306e\u6dfb\u52a0\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n<h3>GDF-8\u306e\u518d\u69cb\u6210\u65b9\u6cd5\u3092\u6559\u3048\u3066\u304f\u3060\u3055\u3044\u3002<\/h3>\n<p>\u4e0a\u8a18\u306e\u6eb6\u89e3\u624b\u9806\u306b\u5f93\u3063\u3066\u304f\u3060\u3055\u3044\u3002\u9759\u83cc\u6c34\u3092\u30d0\u30a4\u30a2\u30eb\u306e\u5074\u58c1\u306b\u6cbf\u3063\u3066\u52a0\u3048\uff08\u51cd\u7d50\u4e7e\u71e5\u30b1\u30fc\u30ad\u306b\u76f4\u63a5\u304b\u3051\u306a\u3044\u3067\u304f\u3060\u3055\u3044\uff09\u3001\u9759\u304b\u306b\u65cb\u56de\u3055\u305b\u3001\u5b8c\u5168\u306b\u6eb6\u89e3\u3059\u308b\u307e\u30675\uff5e10\u5206\u9593\u5f85\u3061\u307e\u3059\u3002\u6fc0\u3057\u304f\u632f\u3089 <strong>\u3057\u307e\u305b\u3093<\/strong> \u30d0\u30a4\u30a2\u30eb\u3092\u632f\u3089\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002\u6fc0\u3057\u3044\u652a\u62cc\u306f\u5206\u5b50\u9593\u30b8\u30b9\u30eb\u30d5\u30a3\u30c9\u7d50\u5408\u3092\u7834\u58ca\u3057\u3001\u6d3b\u6027\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u6b63\u3057\u304f\u518d\u69cb\u6210\u3055\u308c\u305f\u6eb6\u6db2\u306f\u7121\u8272\u900f\u660e\u3067\u3001\u76ee\u306b\u898b\u3048\u308b\u7c92\u5b50\u306f\u3042\u308a\u307e\u305b\u3093\u30021 mg\u30d0\u30a4\u30a2\u30eb\uff0b1.0 mL\u5e0c\u91c8\u6db2\u306e\u5834\u5408\u3001\u4f5c\u696d\u6fc3\u5ea6\u306f1 mg\/mL\u3067\u3059\u3002<\/p>\n<h3>\u7d14\u5ea6\u306e\u898f\u683c\u304c99%\u3067\u306f\u306a\u304f95%\u306a\u306e\u306f\u306a\u305c\u3067\u3059\u304b\uff1f<\/h3>\n<p>GDF-8\u306e\u3088\u3046\u306a\u7d44\u63db\u3048\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u4f4e\u5206\u5b50\u5408\u6210\u30da\u30d7\u30c1\u30c9\u306b\u5178\u578b\u7684\u306a\u226599% HPLC\u7d14\u5ea6\u57fa\u6e96\u3092\u9054\u6210\u3067\u304d\u307e\u305b\u3093\u3002\u3053\u308c\u306f\u3001\u3042\u3089\u3086\u308b\u7d44\u63db\u3048\u767a\u73fe\u7cfb\u306b\u5185\u5728\u3059\u308b\u4e0d\u5747\u4e00\u6027\u306b\u3088\u308b\u3082\u306e\u3067\u3001\u7570\u306a\u308b\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u4e2d\u9593\u4f53\u3084\u30b8\u30b9\u30eb\u30d5\u30a3\u30c9\u7570\u6027\u4f53\u304cHPLC\u4e0a\u3067\u95a2\u9023\u30d4\u30fc\u30af\u3068\u3057\u3066\u73fe\u308c\u307e\u3059\u304c\u3001\u3053\u308c\u3089\u306f\u4e0d\u7d14\u7269\u3067\u306f\u306a\u304f\u6a19\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u3067\u3059\u3002\u226595% HPLC\u7d14\u5ea6\u306f\u3001GDF-8\u304a\u3088\u3073\u985e\u4f3c\u306e\u7d44\u63db\u3048\u30b8\u30b9\u30eb\u30d5\u30a3\u30c9\u7d50\u5408\u4e8c\u91cf\u4f53\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6a19\u6e96\u7684\u306a\u7814\u7a76\u30b0\u30ec\u30fc\u30c9\u306e\u898f\u683c\u3067\u3059\u3002SDS-PAGE\u3067\u306f\u3001\u901a\u5e38\u3001\u975e\u9084\u5143\u6761\u4ef6\u4e0b\u3067\u4e88\u60f3\u3055\u308c\u308b\u7d0425.8 kDa\u306e\u30d0\u30f3\u30c9\u304c\u3001\u9084\u5143\u6761\u4ef6\u4e0b\u3067\u306f\u7d0412.9 kDa\u306e\u30e2\u30ce\u30de\u30fc\u304c\u793a\u3055\u308c\u307e\u3059\u3002<\/p>\n<h3>MedsBase\u3067\u306f\u3069\u306e\u5bb9\u91cf\u306e\u30ec\u30bf\u30eb\u30c8\u30eb\u30c1\u30c9\u3092\u53d6\u308a\u63c3\u3048\u3066\u3044\u307e\u3059\u304b\uff1f<\/h3>\n<p>MedsBase\u3067\u306f\u3001\u7d44\u63db\u3048GDF-8\uff08\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\uff09\u30921 mg\u51cd\u7d50\u4e7e\u71e5\u30d0\u30a4\u30a2\u30eb\u3067\u53d6\u308a\u6271\u3063\u3066\u3044\u307e\u3059\u3002\u30d0\u30a4\u30a2\u30eb\u306f10\u30d0\u30a4\u30a2\u30eb\u307e\u305f\u306f20\u30d0\u30a4\u30a2\u30eb\u306e\u30d1\u30c3\u30af\u30b5\u30a4\u30ba\u3067\u3054\u5229\u7528\u3044\u305f\u3060\u3051\u307e\u3059\u3002\u3059\u3079\u3066\u306e\u30d0\u30a4\u30a2\u30eb\u306f\u226595% HPLC\u7d14\u5ea6\u3067\u4f9b\u7d66\u3055\u308c\u3001\u5206\u6790\u8a3c\u660e\u66f8\u306f\u3054\u8981\u671b\u306b\u5fdc\u3058\u3066\u5165\u624b\u53ef\u80fd\u3067\u3059\u3002<\/p>\n<h3>GDF-8\u3068\u30d5\u30a9\u30ea\u30b9\u30bf\u30c1\u30f3344\u306f\u7814\u7a76\u3067\u4f75\u7528\u3067\u304d\u307e\u3059\u304b\uff1f<\/h3>\n<p>\u306f\u3044\u3001\u3053\u308c\u306f\u6a19\u6e96\u7684\u306a\u4f7f\u7528\u4f8b\u3067\u3059\u3002\u3053\u306e2\u3064\u306f\u4e3b\u306b3\u3064\u306e\u65b9\u6cd5\u3067\u65e5\u5e38\u7684\u306b\u4f75\u7528\u3055\u308c\u307e\u3059\uff1a(1) SPR\u3001ELISA\u3001\u307e\u305f\u306fITC\u306b\u3088\u308b\u30d5\u30a9\u30ea\u30b9\u30bf\u30c1\u30f3\u2013\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u76f8\u4e92\u4f5c\u7528\u306e\u7d50\u5408\u89aa\u548c\u6027\u6e2c\u5b9a\u3001(2) GDF-8\u304c\u7b4b\u7ba1\u840e\u7e2e\u3092\u8a98\u5c0e\u3057\u3001\u30d5\u30a9\u30ea\u30b9\u30bf\u30c1\u30f3\u306e\u4f75\u7528\u51e6\u7406\u306b\u3088\u308a\u56de\u5fa9\u3059\u308b\u7d30\u80de\u30d9\u30fc\u30b9\u306e\u840e\u7e2e\/\u30ec\u30b9\u30ad\u30e5\u30fc\u30a2\u30c3\u30bb\u30a4\u3001(3) GDF-8\u304c\u6d88\u8017\u8868\u73fe\u578b\u3092\u5897\u5e45\u3057\u3001\u30d5\u30a9\u30ea\u30b9\u30bf\u30c1\u30f3\u306e\u4f75\u7528\u6295\u4e0e\u306b\u3088\u308a\u8efd\u6e1b\u3059\u308bin vivo\u7814\u7a76\u3002\u3053\u306e\u9006\u85ac\u7406\u5b66\u7684\u4f75\u7528\u306f\u3001\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u7d4c\u8def\u306e\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\u306e\u57fa\u790e\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3>GDF-8\u306f\u7814\u7a76\u306b\u304a\u3044\u3066\u526f\u4f5c\u7528\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u304b\uff1f<\/h3>\n<p>\u7814\u7a76\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u7d44\u63db\u3048GDF-8\u306e\u4e3b\u306a\u6a19\u7684\u4f5c\u7528\u306f\u7b4b\u840e\u7e2e\u3067\u3059\u3002\u3053\u308c\u306f\u610f\u56f3\u3055\u308c\u305f\u85ac\u7406\u4f5c\u7528\u3067\u3042\u308a\u3001\u526f\u4f5c\u7528\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u30aa\u30d5\u30bf\u30fc\u30b2\u30c3\u30c8\u6240\u898b\u3068\u3057\u3066\u306f\u3001\u5fc3\u81d3\u7d44\u7e54\u304a\u3088\u3073\u8102\u80aa\u7d44\u7e54\u306b\u304a\u3051\u308bActRIIB\u306e\u4f4e\u30ec\u30d9\u30eb\u306e\u767a\u73fe\u3068\u4e00\u81f4\u3059\u308b\u8efd\u5ea6\u306e\u5f71\u97ff\u304c\u542b\u307e\u308c\u307e\u3059\u3002\u975e\u5e38\u306b\u9ad8\u7528\u91cf\u3067\u306f\u3001\u30a2\u30af\u30c1\u30d3\u30f3\u304a\u3088\u3073GDF-11\u7d4c\u8def\u3068\u306e\u53d7\u5bb9\u4f53\u30af\u30ed\u30b9\u30c8\u30fc\u30af\u306b\u8d77\u56e0\u3059\u308b\u3001\u7dda\u7dad\u5316\u304a\u3088\u3073\u708e\u75c7\u306b\u95a2\u3059\u308bTGF-\u03b2\u30b9\u30fc\u30d1\u30fc\u30d5\u30a1\u30df\u30ea\u30fc\u95a2\u9023\u306e\u3088\u308a\u5e83\u7bc4\u306a\u5f71\u97ff\u304c\u89b3\u5bdf\u3055\u308c\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<h3>GDF-8\u306e\u534a\u6e1b\u671f\u306f\u3069\u306e\u304f\u3089\u3044\u3067\u3059\u304b\uff1f<\/h3>\n<p>\u524d\u81e8\u5e8a\u7814\u7a76\u3067\u306f\u3001\u7d44\u63db\u3048\u6210\u719f\u578bGDF-8\u306e\u8840\u6f3f\u4e2d\u534a\u6e1b\u671f\u306f\u9759\u8108\u5185\u6295\u4e0e\u5f8c\u7d042\uff5e4\u6642\u9593\u3067\u3059\u3002\u5185\u56e0\u6027\u306b\u306f\u3001\u6210\u719f\u578b\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u306f\u81ea\u8eab\u306e\u30d7\u30ed\u30c9\u30e1\u30a4\u30f3\uff08\u6f5c\u5728\u578b\u8907\u5408\u4f53\uff09\u304a\u3088\u3073\u30d5\u30a9\u30ea\u30b9\u30bf\u30c1\u30f3\/\u4ed6\u306e\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u7d50\u5408\u3057\u3066\u5faa\u74b0\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u306b\u3088\u308a\u5b9f\u52b9\u7d44\u7e54\u534a\u6e1b\u671f\u304c\u5927\u5e45\u306b\u5ef6\u9577\u3055\u308c\u307e\u3059\u3002\u7814\u7a76\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u3067\u306f\u3001\u7d44\u63db\u3048\u6d3b\u6027\u4e8c\u91cf\u4f53\u306f\u30d7\u30ed\u30c9\u30e1\u30a4\u30f3\u306a\u3057\u3067\u6295\u4e0e\u3055\u308c\u3001\u300c\u904a\u96e2\u300d\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u3092ActRIIB\u53d7\u5bb9\u4f53\u306b\u5c4a\u3051\u307e\u3059\u3002<\/p>\n<h3>GDF-8\u304c\u6700\u521d\u306b\u767a\u898b\u3055\u308c\u305f\u7406\u7531\u306f\u4f55\u3067\u3059\u304b\uff1f<\/h3>\n<p>GDF-8\u306f\u30011997\u5e74\u306b\u30b8\u30e7\u30f3\u30ba\u30fb\u30db\u30d7\u30ad\u30f3\u30b9\u5927\u5b66\u306eMcPherron\u3001Lawler\u3001Lee\u3089\u306b\u3088\u308a\u3001\u65b0\u898f\u306eTGF-\u03b2\u30b9\u30fc\u30d1\u30fc\u30d5\u30a1\u30df\u30ea\u30fc\u30e1\u30f3\u30d0\u30fc\u3092\u898b\u3064\u3051\u308b\u305f\u3081\u306b\u8a2d\u8a08\u3055\u308c\u305f\u7e2e\u91cdPCR\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u6cd5\u3092\u7528\u3044\u3066\u540c\u5b9a\u3055\u308c\u307e\u3057\u305f\uff08Nature 1997\uff09\u3002\u30de\u30a6\u30b9\u3067\u306e\u6a19\u7684\u7834\u58ca\u306b\u3088\u308a\u3001\u91ce\u751f\u578b\u5bfe\u7167\u3068\u6bd4\u8f03\u3057\u3066\u9aa8\u683c\u7b4b\u91cf\u304c2\uff5e3\u500d\u306b\u5897\u52a0\u3057\u305f\u52d5\u7269\u304c\u4f5c\u51fa\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u975e\u5e38\u306b\u660e\u78ba\u306a\u8868\u73fe\u578b\u3067\u3042\u308a\u3001\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u304c\u7b4b\u6210\u9577\u306e\u4e3b\u8981\u306a\u751f\u7406\u7684\u8ca0\u306e\u8abf\u7bc0\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u3092\u5373\u5ea7\u306b\u78ba\u7acb\u3057\u307e\u3057\u305f\u3002\u30d9\u30eb\u30b8\u30a2\u30f3\u30d6\u30eb\u30fc\u725b\u3084\u30db\u30a4\u30da\u30c3\u30c8\u72ac\u3067\u81ea\u7136\u767a\u751f\u3059\u308b\u300c\u4e8c\u91cd\u7b4b\u8089\u300d\u8868\u73fe\u578b\u3068\u306e\u95a2\u9023\u306f\u6570\u304b\u6708\u4ee5\u5185\u306b\u78ba\u7acb\u3055\u308c\u3001\u30d2\u30c8\u306eMSTN\u5909\u7570\u75c7\u4f8b\u306f2004\u5e74\u306bNEJM\u3067\u767a\u8868\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<h3>GDF-8\u304c\u524d\u81e8\u5e8a\u7814\u7a76\u3067\u52b9\u679c\u3092\u793a\u3059\u307e\u3067\u306b\u3069\u306e\u304f\u3089\u3044\u306e\u6642\u9593\u304c\u304b\u304b\u308a\u307e\u3059\u304b\uff1f<\/h3>\n<p>Smad2\/Smad3\u30ea\u30f3\u9178\u5316\u306b\u5bfe\u3059\u308bin vitro\u3067\u306e\u52b9\u679c\u306f\u3001\u7d30\u80de\u66dd\u9732\u304b\u3089\u6570\u5206\u4ee5\u5185\u306b\u691c\u51fa\u53ef\u80fd\u3067\u3059\u3002\u7d30\u80de\u30d9\u30fc\u30b9\u306e\u30a2\u30c3\u30bb\u30a4\u306b\u304a\u3051\u308b\u7b4b\u7ba1\u840e\u7e2e\u306f\u300124\uff5e72\u6642\u9593\u4ee5\u5185\u306b\u6e2c\u5b9a\u53ef\u80fd\u3067\u3059\u3002\u3052\u3063\u6b6f\u985e\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308bin vivo\u3067\u306e\u840e\u7e2e\u8868\u73fe\u578b\u306f\u3001\u5b9a\u671f\u7684\u306a\u6295\u4e0e\u30921\uff5e4\u9031\u9593\u7d9a\u3051\u308b\u3053\u3068\u3067\u767a\u73fe\u3057\u3001\u305d\u306e\u901f\u5ea6\u306f\u7528\u91cf\u3001\u6295\u4e0e\u7d4c\u8def\u3001\u304a\u3088\u3073\u30e2\u30c7\u30eb\u751f\u7269\u306e\u57fa\u790e\u7684\u306a\u7b4b\u91cf\u306b\u4f9d\u5b58\u3057\u307e\u3059\u3002<\/p>\n<h3>GDF-8\u3092\u56fd\u969b\u914d\u9001\u3067\u6ce8\u6587\u3067\u304d\u307e\u3059\u304b\uff1f<\/h3>\n<p>Yes. MedsBase ships GDF-8 worldwide from our dedicated peptide shipping network. Peptide-only orders qualify for our standalone peptide shipping service. All orders ship in temperature-controlled packaging with full tracking and are covered by our <a href=\"https:\/\/medsbase.com\/ja\/medsbase-re-shipment-assurance-policy\/\">\u518d\u767a\u9001\u4fdd\u8a3c\u30dd\u30ea\u30b7\u30fc<\/a>.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>\u540c\u5316\u3001\u7b4b\u8089\u3001\u6210\u9577\u8ef8\u7814\u7a76\u7528\u306e\u305d\u306e\u4ed6\u306e\u30da\u30d7\u30c1\u30c9<\/h2>\n<ul>\n<li><a href=\"\/ja\/follistatin-344\/\"><strong>Follistatin 344<\/strong><\/a> \u2014 \u30df\u30aa\u30b9\u30bf\u30c1\u30f3\uff0f\u30a2\u30af\u30c1\u30d3\u30f3\u30a2\u30f3\u30bf\u30b4\u30cb\u30b9\u30c8\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea \u2014 GDF-8\u306b\u5bfe\u3059\u308b\u9006\u85ac\u7406\u5b66\u7684\u30da\u30a2<\/li>\n<li><a href=\"\/ja\/igf-1-lr3\/\"><strong>IGF-1 LR3<\/strong><\/a> \u2014 \u9577\u9396\u30a2\u30eb\u30ae\u30cb\u30f3\u7d44\u63db\u3048IGF-1\u30a2\u30ca\u30ed\u30b0 \u2014 IGF-1R\u3092\u4ecb\u3059\u308b\u9006\u7d4c\u8def\u306e\u540c\u5316\u523a\u6fc0<\/li>\n<li><a href=\"\/ja\/tb-500\/\"><strong>TB-500\uff08\u30b5\u30a4\u30e2\u30b7\u30f3\u30d9\u30fc\u30bf-4\uff09<\/strong><\/a> \u2014 \u5168\u8eab\u6027\u6cbb\u7652\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8 \u2014 \u7b4b\u8089\u304a\u3088\u3073\u5fc3\u81d3\u306e\u56de\u5fa9\u7814\u7a76<\/li>\n<li><a href=\"\/ja\/cjc-1295-with-dac\/\"><strong>CJC-1295 with DAC<\/strong><\/a> \u2014 \u9577\u6642\u9593\u4f5c\u7528\u578bGHRH\u30a2\u30ca\u30ed\u30b0 \u2014 \u6210\u9577\u30db\u30eb\u30e2\u30f3\u8ef8\u7814\u7a76\u7528<\/li>\n<li><a href=\"\/ja\/sermorelin\/\"><strong>Sermorelin<\/strong><\/a> \u2014 \u77ed\u6642\u9593\u4f5c\u7528\u578bGHRH(1-29)\u30a2\u30ca\u30ed\u30b0 \u2014 \u81ea\u7136\u306aGH\u5206\u6ccc\u30d1\u30eb\u30b9\u306e\u7814\u7a76<\/li>\n<\/ul>\n<p><!-- medsbase-peptide-guide-cta --><\/p>\n<h2>\u53c2\u8003\u6587\u732e<\/h2>\n<div style=\"background: #f4f8fb; border-left: 4px solid #2c7cb0; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<p style=\"margin: 0 0 8px 0;\"><strong>\ud83d\udcd6 \u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u7d4c\u8def\u3092\u63a2\u308b<\/strong><\/p>\n<p style=\"margin: 0;\">\u3059\u3079\u3066\u3092\u95b2\u89a7 <a href=\"https:\/\/medsbase.com\/ja\/peptides\/\"><strong>\u7814\u7a76\u7528\u30da\u30d7\u30c1\u30c9\u30ab\u30bf\u30ed\u30b0<\/strong><\/a>, \u3001\u9006\u85ac\u7406\u5b66\u7684\u30da\u30a2\u3068\u3068\u3082\u306b <a href=\"https:\/\/medsbase.com\/ja\/follistatin-344\/\">Follistatin 344<\/a> \u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u30a2\u30f3\u30bf\u30b4\u30cb\u30b9\u30c8\u3068\u3057\u3066\u3001, <a href=\"https:\/\/medsbase.com\/ja\/igf-1-lr3\/\">IGF-1 LR3<\/a> \u76f4\u63a5IGF\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u305f\u540c\u5316\u7814\u7a76\u306e\u305f\u3081\u306b\u3001\u304a\u3088\u3073 <a href=\"https:\/\/medsbase.com\/ja\/tb-500\/\">TB-500<\/a> \u5168\u8eab\u306e\u7b4b\u8089\u304a\u3088\u3073\u7d44\u7e54\u306e\u56de\u5fa9\u7814\u7a76\u7528\u3002<\/p>\n<\/div>\n<p><!-- pep-seo-v1 --><\/p>","protected":false},"excerpt":{"rendered":"<p>\u2705 \u907a\u4f1d\u5b50\u7d44\u63db\u304825.8 kDa\u6d3b\u6027\u578b\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u30db\u30e2\u4e8c\u91cf\u4f53<br \/>\n\u2705 \u6a19\u6e96\u7684\u306aTGF-\u03b2\u30b9\u30fc\u30d1\u30fc\u30d5\u30a1\u30df\u30ea\u30fc\u840e\u7e2e\u6027\u30ea\u30ac\u30f3\u30c9<br \/>\n\u2705 Follistatin 344\u306e\u9006\u85ac\u7406\u5b66\u7684\u30d1\u30fc\u30c8\u30ca\u30fc<br \/>\n\u2705 ActRIIB\/Smad2\/Smad3\u7d4c\u8def\u30a2\u30b4\u30cb\u30b9\u30c8<br \/>\n\u2705 HPLC\u7d14\u5ea695%\u4ee5\u4e0a\u3001\u5206\u6790\u8a3c\u660e\u66f8\u306f\u3054\u8981\u671b\u306b\u5fdc\u3058\u3066\u63d0\u4f9b<\/p>\n<p><strong>GDF-8 (Myostatin)<\/strong> \u306f\u7d44\u63db\u3048\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u3002<\/p>","protected":false},"featured_media":70950,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[5426],"product_tag":[6279,6278,5441],"class_list":{"0":"post-70729","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptides","7":"product_tag-gdf-8","8":"product_tag-myostatin","9":"product_tag-peptide","11":"first","12":"instock","13":"shipping-taxable","14":"purchasable","15":"product-type-variable","16":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ja\/wp-json\/wp\/v2\/product\/70729","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ja\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ja\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ja\/wp-json\/wp\/v2\/comments?post=70729"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ja\/wp-json\/wp\/v2\/media\/70950"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ja\/wp-json\/wp\/v2\/media?parent=70729"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ja\/wp-json\/wp\/v2\/product_brand?post=70729"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ja\/wp-json\/wp\/v2\/product_cat?post=70729"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ja\/wp-json\/wp\/v2\/product_tag?post=70729"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}