{"id":71392,"date":"2026-05-20T08:54:38","date_gmt":"2026-05-20T08:54:38","guid":{"rendered":"https:\/\/medsbase.com\/ll-37\/"},"modified":"2026-05-21T07:14:09","modified_gmt":"2026-05-21T07:14:09","slug":"ll-37","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ja\/product\/ll-37\/","title":{"rendered":"LL-37\uff08\u30ab\u30c6\u30ea\u30b7\u30b8\u30f3\u6297\u83cc\u30da\u30d7\u30c1\u30c9\uff09"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background: #fff8e1; border-left: 4px solid #f5a623; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<h3 style=\"margin: 0 0 8px 0; font-size: 16px; color: #1a4a6b;\">\u30af\u30a4\u30c3\u30af\u30a2\u30f3\u30b5\u30fc \u2014 LL-37\u3068\u306f\u4f55\u3067\u3059\u304b\uff1f<\/h3>\n<p style=\"margin: 0;\"><strong>LL-37<\/strong> \uff08\u30ab\u30c6\u30ea\u30b7\u30b8\u30f3\u6297\u83cc\u30da\u30d7\u30c1\u30c9\u3001CAP-18\u3001\u307e\u305f\u306fFALL-39\u3068\u3082\u547c\u3070\u308c\u308b\uff09\u306f\u300137\u30a2\u30df\u30ce\u9178\u304b\u3089\u306a\u308b\u4e21\u89aa\u5a92\u6027\u03b1\u30d8\u30ea\u30c3\u30af\u30b9\u5bbf\u4e3b\u9632\u5fa1\u30da\u30d7\u30c1\u30c9\u3067\u3042\u308a\u3001\u552f\u4e00\u306e\u30d2\u30c8\u30ab\u30c6\u30ea\u30b7\u30b8\u30f3\u3067\u3059\u3002\u4e0d\u6d3b\u6027\u524d\u99c6\u4f53\uff08hCAP-18\uff09\u304b\u3089\u30d7\u30ed\u30c6\u30a4\u30ca\u30fc\u30bc3\u306b\u3088\u308b\u5207\u65ad\u3067\u653e\u51fa\u3055\u308c\u3001\u7d30\u83cc\u3001\u771f\u83cc\u3001\u30a8\u30f3\u30d9\u30ed\u30fc\u30d7\u30a6\u30a4\u30eb\u30b9\u3001\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u306b\u5bfe\u3059\u308b\u76f4\u63a5\u7684\u306a\u5e83\u57df\u6297\u83cc\u6d3b\u6027\u3068\u3001LPS\u4e2d\u548c\u3001\u597d\u4e2d\u7403\/\u5358\u7403\/T\u7d30\u80de\u306e\u8d70\u5316\u6027\u3001\u6297\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u4f5c\u7528\u3001\u8840\u7ba1\u65b0\u751f\u4fc3\u9032\u6027\u306e\u5275\u50b7\u6cbb\u7652\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3068\u3044\u3063\u305f\u5f37\u529b\u306a\u514d\u75ab\u8abf\u7bc0\u4f5c\u7528\u3092\u4f75\u305b\u6301\u3061\u307e\u3059\u3002LL-37\u306f\u3001\u6297\u83cc\u85ac\u8010\u6027\u7814\u7a76\u3001\u5275\u50b7\u6cbb\u7652\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u3001\u4e7e\u766c\u306e\u75c5\u614b\u3001\u816b\u760d\u5b66\u306b\u308f\u305f\u3063\u3066\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u30025 mg\u51cd\u7d50\u4e7e\u71e5\u30d0\u30a4\u30a2\u30eb\u3067\u4f9b\u7d66\u3055\u308c\u3001\u7814\u7a76\u7528\u306e\u307f\u306b\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background: #f4f8fb; border: 1px solid #d8e3eb; padding: 12px 16px; margin: 16px 0; border-radius: 4px; font-size: 14px;\"><strong>MedsBase\u3067\u5f97\u3089\u308c\u308b\u3082\u306e\uff1a<\/strong> \u7814\u7a76\u30b0\u30ec\u30fc\u30c9\u306e\u51cd\u7d50\u4e7e\u71e5\u30da\u30d7\u30c1\u30c9 \u00b7 HPLC\u7d14\u5ea699%\u4ee5\u4e0a\uff08COA\u306f\u3054\u8981\u671b\u306b\u5fdc\u3058\u3066\uff09 \u00b7 \u4e2d\u8eab\u304c\u308f\u304b\u3089\u306a\u3044\u6e29\u5ea6\u5b89\u5b9a\u6027\u5305\u88c5 \u00b7 \u30da\u30d7\u30c1\u30c9\u306e\u5168\u4e16\u754c\u914d\u9001 \u00b7 1,400\u4ef6\u4ee5\u4e0a\u306e\u691c\u8a3c\u6e08\u307f <a href=\"https:\/\/medsbase.com\/ja\/reviews\/\">\u30ab\u30b9\u30bf\u30de\u30fc\u30ec\u30d3\u30e5\u30fc<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size: 14px; color: #444; margin: 8px 0 18px;\">\ud83d\udce6 \u3059\u3079\u3066\u306e\u3054\u6ce8\u6587\u306f\u3001\u5f53\u5e97\u306e <a href=\"https:\/\/medsbase.com\/ja\/medsbase-re-shipment-assurance-policy\/\"><strong>\u518d\u767a\u9001\u4fdd\u8a3c\u30dd\u30ea\u30b7\u30fc<\/strong><\/a> \u2014 \u4e07\u304c\u4e00\u300120\u55b6\u696d\u65e5\u4ee5\u5185\u306b\u5546\u54c1\u304c\u5c4a\u304b\u306a\u3044\u5834\u5408\u306f\u3001\u518d\u767a\u9001\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n<table class=\"medsbase-spec-table\" style=\"width: 100%; border-collapse: collapse; margin: 18px 0; font-size: 14px;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 8px 12px; text-align: left; width: 30%;\">\u4ed5\u69d8<\/th>\n<th style=\"padding: 8px 12px; text-align: left;\">\u8a73\u7d30<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>CAS\u756a\u53f7<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">154947-66-7 (LL-37 \u30d5\u30ea\u30fc\u30d9\u30fc\u30b9)<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u30bf\u30a4\u30d7<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">37\u30a2\u30df\u30ce\u9178\u304b\u3089\u306a\u308b\u4e21\u89aa\u5a92\u6027\u03b1\u30d8\u30ea\u30c3\u30af\u30b9\u30ab\u30c1\u30aa\u30f3\u6027\u6297\u83cc\u5bbf\u4e3b\u9632\u5fa1\u30da\u30d7\u30c1\u30c9\uff1b\u552f\u4e00\u306e\u30d2\u30c8\u30ab\u30c6\u30ea\u30b7\u30b8\u30f3\uff08CAMP\u907a\u4f1d\u5b50\u7523\u7269\uff09\uff1b\u4e0d\u6d3b\u6027\u524d\u99c6\u4f53hCAP-18\u306e\u30d7\u30ed\u30c6\u30a4\u30ca\u30fc\u30bc3\u5207\u65ad\u306b\u3088\u308a\u653e\u51fa\u3055\u308c\u308b\u6d3b\u6027C\u672b\u7aef\u30da\u30d7\u30c1\u30c9\uff1b\u307e\u305f\u3001CAP-18\uff0818 kDa\u524d\u99c6\u4f53\u306eC\u672b\u7aef\u30ab\u30c6\u30ea\u30b7\u30b8\u30f3\u6297\u83cc\u30da\u30d7\u30c1\u30c9\uff09\u304a\u3088\u3073FALL-39\uff08\u4ee5\u524d\u306e\u914d\u5217\u6c7a\u5b9a\u3067N\u672b\u7aef\u306eF\u6b8b\u57fa\u3092\u542b\u3080\u5834\u5408\uff09\u3068\u3082\u547c\u3070\u308c\u307e\u3059\u3002<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u5206\u5b50\u5f0f<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">C<sub>205<\/sub>H<sub>340<\/sub>N<sub>60<\/sub>O<sub>53<\/sub><\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u5206\u5b50\u91cf<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">~4,493.3 Da<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u914d\u5217<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH (LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES) \u2014 \u76f4\u9396\u72b637\u6b8b\u57fa\u30ab\u30c1\u30aa\u30f3\u6027\u30da\u30d7\u30c1\u30c9\uff1b\u4e2d\u6027pH\u3067\u6b63\u5473+6\u306e\u96fb\u8377\uff1b\u8102\u8cea\/\u819c\u74b0\u5883\u3067\u4e21\u89aa\u5a92\u6027\u03b1\u30d8\u30ea\u30c3\u30af\u30b9\u306b\u6298\u308a\u305f\u305f\u307e\u308c\u307e\u3059\u3002\u904a\u96e2N\u672b\u7aef\u304a\u3088\u3073C\u672b\u7aef\uff1b\u30b8\u30b9\u30eb\u30d5\u30a3\u30c9\u7d50\u5408\u306a\u3057\u3001\u30a2\u30b7\u30eb\u5316\u306a\u3057\u3001PEG\u5316\u306a\u3057\u3002<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u5f62\u614b<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u51cd\u7d50\u4e7e\u71e5\u7c89\u672b\uff08\u767d\u8272\u301c\u5fae\u9ec4\u8272\uff09<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u7d14\u5ea6<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u226599%\uff08HPLC\u691c\u8a3c\u6e08\u307f\u3001COA\u306f\u3054\u8981\u671b\u306b\u5fdc\u3058\u3066\u63d0\u4f9b\uff09<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u4fdd\u7ba1\u65b9\u6cd5<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u51cd\u7d50\u4e7e\u71e5\u54c1\uff1a\u77ed\u671f\u4f7f\u7528\u306e\u30b9\u30c8\u30c3\u30af\u306f2\uff5e8 \u00b0C\uff08\u51b7\u8535\u5eab\uff09\u3001\u672a\u958b\u5c01\u30d0\u30a4\u30a2\u30eb\u306e\u9577\u671f\u4fdd\u5b58\u306f\u221220 \u00b0C\u3067\u4fdd\u7ba1\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u518d\u6eb6\u89e3\u5f8c\uff1a2\uff5e8 \u00b0C\u3001\u7d0414\uff5e28\u65e5\u4ee5\u5185\u306b\u3054\u4f7f\u7528\u304f\u3060\u3055\u3044\u3002\u5149\u304b\u3089\u4fdd\u8b77\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u51cd\u7d50\u878d\u89e3\u306e\u7e70\u308a\u8fd4\u3057\u306f\u907f\u3051\u3066\u304f\u3060\u3055\u3044\u3002\u30ab\u30c1\u30aa\u30f3\u6027\u6297\u83cc\u30da\u30d7\u30c1\u30c9\u306f\u30d7\u30e9\u30b9\u30c1\u30c3\u30af\u8868\u9762\u306b\u5438\u7740\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u30b9\u30c8\u30c3\u30af\u306e\u4fdd\u5b58\u3084\u5e0c\u91c8\u306b\u306f\u4f4e\u5438\u7740\u30c1\u30e5\u30fc\u30d6\uff08\u30b7\u30ea\u30b3\u30f3\u30b3\u30fc\u30c6\u30a3\u30f3\u30b0\u307e\u305f\u306fProtein LoBind\uff09\u306e\u4f7f\u7528\u3092\u304a\u3059\u3059\u3081\u3057\u307e\u3059\u3002<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u6eb6\u89e3\u6027<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u9759\u83cc\u6c34\u3001\u6ec5\u83cc\u6c34\u3001\u307e\u305f\u306f\u5e0c\u9162\u9178\uff080.01\uff5e0.1%\uff09\u306b\u9ad8\u3044\u6eb6\u89e3\u6027\u3092\u793a\u3057\u307e\u3059\u3002\u9178\u6027\u304b\u3089\u4e2d\u6027\u306epH\u3067\u518d\u6eb6\u89e3\u3057\u3001\u30b9\u30c8\u30c3\u30af\u6eb6\u6db2\u306b\u306f\u9ad8\u5869\u6fc3\u5ea6\u3084\u5f37\u5869\u57fa\u6027\u306e\u7de9\u885d\u6db2\u3092\u4f7f\u7528\u3057\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002\u4e21\u89aa\u5a92\u6027\u03b1\u30d8\u30ea\u30c3\u30af\u30b9\u306f\u9ad8\u6fc3\u5ea6\u3067\u51dd\u96c6\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u4f7f\u7528\u76f4\u524d\u306b\u4f7f\u7528\u6fc3\u5ea6\u306b\u5e0c\u91c8\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u7814\u7a76\u7528\u9014<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u5b9f\u9a13\u5ba4\u7814\u7a76\u7528\u306e\u307f\u3067\u3059\u3002\u30d2\u30c8\u307e\u305f\u306f\u52d5\u7269\u306e\u8a3a\u65ad\u30fb\u6cbb\u7642\u76ee\u7684\u306b\u306f\u4f7f\u7528\u3057\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><!-- \/medsbase-tldr-answer --><\/p>\n<h2>LL-37\u3068\u306f\u4f55\u3067\u3059\u304b\uff1f<\/h2>\n<p><strong>LL-37<\/strong> \u306f\u3001\u30d2\u30c8\u30ab\u30c6\u30ea\u30b7\u30b8\u30f3\u6297\u83cc\u30da\u30d7\u30c1\u30c9hCAP-18\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u5207\u65ad\u306b\u3088\u308a\u653e\u51fa\u3055\u308c\u308b\u6d3b\u6027\u578bC\u672b\u7aef37\u30a2\u30df\u30ce\u9178\u30da\u30d7\u30c1\u30c9\u3067\u3042\u308a\u3001\u30d2\u30c8\u306b\u304a\u3051\u308b\u552f\u4e00\u306e\u30ab\u30c6\u30ea\u30b7\u30b8\u30f3\u907a\u4f1d\u5b50\u7523\u7269\u3067\u3001\u30b3\u30fc\u30c9\u3055\u308c\u3066\u3044\u308b\u306e\u306f <em>CAMP<\/em> \u67d3\u8272\u4f533\u4e0a\u306e\u907a\u4f1d\u5b50\u3067\u3059\u3002\u3053\u306e\u30da\u30d7\u30c1\u30c9\u306e\u540d\u79f0\u306f\u3001\u6700\u521d\u306e2\u6b8b\u57fa\uff08Leu-Leu\uff09\u3068\u305d\u306e\u9577\u3055\uff0837\u6b8b\u57fa\uff09\u306b\u7531\u6765\u3057\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u307b\u3068\u3093\u3069\u306e\u810a\u690e\u52d5\u7269\u7cfb\u7d71\u3067\u898b\u3089\u308c\u308b\u81ea\u7136\u514d\u75ab\u306e\u30db\u30b9\u30c8\u9632\u5fa1\u30da\u30d7\u30c1\u30c9\u3067\u3042\u308b\u30ab\u30c6\u30ea\u30b7\u30b8\u30f3\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u5c5e\u3057\u3001\u30d2\u30c8\u306e\u30ab\u30c6\u30ea\u30b7\u30b8\u30f3\u81ea\u7136\u514d\u75ab\u7cfb\u306b\u304a\u3044\u3066\u3001\u30c7\u30a3\u30d5\u30a7\u30f3\u30b7\u30f3\u30d5\u30a1\u30df\u30ea\u30fc\u3068\u3068\u3082\u306b\u4e2d\u5fc3\u7684\u306a\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u5206\u5b50\u3068\u3057\u3066\u6a5f\u80fd\u3057\u307e\u3059\u3002<\/p>\n<p>\u4e0d\u6d3b\u6027\u578b\u306ehCAP-18\u524d\u99c6\u4f53\u306f\u3001\u597d\u4e2d\u7403\u9846\u7c92\u3001\u4e0a\u76ae\u8868\u9762\uff08\u76ae\u819a\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u3001\u6c17\u9053\u4e0a\u76ae\u3001\u8178\u4e0a\u76ae\uff09\u3001\u304a\u3088\u3073\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3001NK\u7d30\u80de\u3001\u30de\u30b9\u30c8\u7d30\u80de\u3001B\u7d30\u80de\u3001\u03b3\u03b4 T\u7d30\u80de\u3067\u5c11\u91cf\u7523\u751f\u3055\u308c\u307e\u3059\u3002\u6d3b\u6027\u5316\u306f\u3001\u30d7\u30ed\u30c6\u30a4\u30ca\u30fc\u30bc3\u5207\u65ad\uff08\u597d\u4e2d\u7403\u5185\uff09\u307e\u305f\u306f\u30ab\u30ea\u30af\u30ec\u30a4\u30f3-5\/\u30ab\u30ea\u30af\u30ec\u30a4\u30f3-7\uff08\u76ae\u819a\u5185\uff09\u306b\u3088\u3063\u3066\u8d77\u3053\u308a\u3001\u819c\u6a21\u5023\u74b0\u5883\u3067\u5f37\u3044\u4e21\u89aa\u5a92\u6027\u03b1\u30d8\u30ea\u30c3\u30af\u30b9\u69cb\u9020\u3092\u3068\u308b\u751f\u7269\u6d3b\u6027\u306e\u3042\u308b37\u6b8b\u57fa\u30da\u30d7\u30c1\u30c9\u304c\u904a\u96e2\u3057\u307e\u3059\u3002\u3053\u306e\u30da\u30d7\u30c1\u30c9\u306f\u4e2d\u6027pH\u3067+6\u306e\u6b63\u5473\u6b63\u96fb\u8377\u3092\u6301\u3061\u3001\u30ab\u30c1\u30aa\u30f3\u6027\u306e\u30ea\u30b8\u30f3\u304a\u3088\u3073\u30a2\u30eb\u30ae\u30cb\u30f3\u6b8b\u57fa\u304c\u30d8\u30ea\u30c3\u30af\u30b9\u306e\u7247\u9762\u306b\u96c6\u4e2d\u3057\u3001\u758e\u6c34\u6027\u306e\u30ed\u30a4\u30b7\u30f3\u3001\u30d5\u30a7\u30cb\u30eb\u30a2\u30e9\u30cb\u30f3\u3001\u30a4\u30bd\u30ed\u30a4\u30b7\u30f3\u3001\u30d0\u30ea\u30f3\u6b8b\u57fa\u304c\u53cd\u5bfe\u5074\u306e\u9762\u306b\u96c6\u4e2d\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u8ca0\u306b\u5e2f\u96fb\u3057\u305f\u5fae\u751f\u7269\u819c\u3068\u306e\u9078\u629e\u7684\u76f8\u4e92\u4f5c\u7528\u3092\u53ef\u80fd\u306b\u3059\u308b\u5178\u578b\u7684\u306a\u300c\u4e21\u89aa\u5a92\u6027\u03b1\u30d8\u30ea\u30c3\u30af\u30b9\u300d\u69cb\u9020\u3067\u3059\u3002<\/p>\n<p>LL-37\u306f\u30011\u3064\u306e\u30da\u30d7\u30c1\u30c9\u306b2\u3064\u306e\u7570\u306a\u308b\u5bbf\u4e3b\u9632\u5fa1\u6a5f\u69cb\u3092\u517c\u306d\u5099\u3048\u3066\u3044\u307e\u3059\u3002\u305d\u306e <strong>\u76f4\u63a5\u7684\u306a\u6297\u83cc\u6d3b\u6027<\/strong> \u306f\u3001\u30b0\u30e9\u30e0\u967d\u6027\u83cc\uff08\u30e1\u30c1\u30b7\u30ea\u30f3\u8010\u6027 <em>S. aureus<\/em>, \u3001MRSA\uff09\u3001\u30b0\u30e9\u30e0\u9670\u6027\u83cc\uff08 <em>E. coli<\/em>, <em>K. pneumoniae<\/em>, <em>P. aeruginosa<\/em>\uff09\u3001\u30a8\u30f3\u30d9\u30ed\u30fc\u30d7\u30a6\u30a4\u30eb\u30b9\uff08HSV-1\u3001\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u3001RSV\uff09\u3001\u771f\u83cc\uff08<em>\u30ab\u30f3\u30b8\u30c0<\/em>\uff09\u3001\u5fae\u751f\u7269\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u3002 <strong>\u514d\u75ab\u8abf\u7bc0\u6d3b\u6027<\/strong> \u7d30\u83cc\u6027\u30ea\u30dd\u591a\u7cd6\uff08LPS\uff09\u304a\u3088\u3073\u30ea\u30dd\u30c6\u30a4\u30b3\u9178\u306e\u7d50\u5408\u3068\u4e2d\u548c\u3001\u30db\u30eb\u30df\u30eb\u30da\u30d7\u30c1\u30c9\u53d7\u5bb9\u4f53\u69d81\uff08FPRL1\/FPR2\uff09\u3092\u4ecb\u3057\u305f\u597d\u4e2d\u7403\uff0f\u5358\u7403\uff0fT\u7d30\u80de\uff0f\u80a5\u6e80\u7d30\u80de\u306e\u8d70\u5316\u6027\u3001TLR\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u8abf\u7bc0\u3001LPS\u8a98\u767a\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30b9\u30c8\u30fc\u30e0\u306e\u6291\u5236\u3001\u5185\u76ae\u7d30\u80de\u306b\u304a\u3051\u308bFPRL1\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u4ecb\u3057\u305f\u8840\u7ba1\u65b0\u751f\u306e\u8a98\u5c0e\u3001\u304a\u3088\u3073\u5275\u50b7\u6cbb\u7652\u306b\u304a\u3051\u308b\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u904a\u8d70\u306e\u523a\u6fc0\u304c\u542b\u307e\u308c\u307e\u3059\u3002LL-37\u306e\u8abf\u7bc0\u7570\u5e38\u306f\u3001\u4e7e\u766c\uff08\u904e\u5270\u306aLL-37\u304c\u81ea\u5df1DNA\u3068\u8907\u5408\u4f53\u3092\u5f62\u6210\u3057\u3066\u5f62\u8cea\u7d30\u80de\u69d8\u6a39\u72b6\u7d30\u80de\u3092\u6d3b\u6027\u5316\u3059\u308b\uff09\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u3001\u7279\u5b9a\u306e\u304c\u3093\u306e\u75c5\u56e0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002LL-37\u306f <strong>\u627f\u8a8d\u3055\u308c\u3066\u3044\u307e\u305b\u3093<\/strong> FDA\u3001EMA\u3001MHRA\u3001\u305d\u306e\u4ed6\u4e3b\u8981\u898f\u5236\u5f53\u5c40\u306b\u3088\u3063\u3066\u30d2\u30c8\u3067\u306e\u6cbb\u7642\u7528\u9014\u3068\u3057\u3066\u627f\u8a8d\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u5f53\u5e97\u3067\u8ca9\u58f2\u3055\u308c\u3066\u3044\u308b\u7814\u7a76\u7528\u30b0\u30ec\u30fc\u30c9\u306eLL-37\u306f\u4f9b\u7d66\u3055\u308c\u3066 <strong>\u7814\u7a76\u5ba4\u7814\u7a76\u7528\u306e\u307f\u3067\u3059<\/strong> \u30d2\u30c8\u307e\u305f\u306f\u52d5\u7269\u3078\u306e\u6295\u4e0e\u3092\u76ee\u7684\u3068\u3057\u305f\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<h2>\u4f5c\u7528\u6a5f\u5e8f \u2014 \u819c\u7834\u58ca\uff0b\u514d\u75ab\u8abf\u7bc0<\/h2>\n<p>LL-37\u306f\u3001\u516c\u8868\u3055\u308c\u305f\u7814\u7a76\u3067\u5831\u544a\u3055\u308c\u3066\u3044\u308b3\u3064\u306e\u4e3b\u8981\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u901a\u3058\u3066\u4f5c\u7528\u3057\u307e\u3059\u3002<\/p>\n<ul>\n<li><strong>\u4e21\u89aa\u5a92\u6027\u03b1\u30d8\u30ea\u30c3\u30af\u30b9\u633f\u5165\u306b\u3088\u308b\u9078\u629e\u7684\u5fae\u751f\u7269\u819c\u7834\u58ca<\/strong> \u2014 \u30d0\u30eb\u30af\u6c34\u6eb6\u6db2\u4e2d\u3067\u306f\u3001LL-37\u306f\u5927\u90e8\u5206\u304c\u69cb\u9020\u3092\u6301\u305f\u306a\u3044\u72b6\u614b\u3067\u3059\u304c\u3001\u9670\u6027\u306b\u8377\u96fb\u3057\u305f\u5fae\u751f\u7269\u819c\uff08\u30db\u30b9\u30d5\u30a1\u30c1\u30b8\u30eb\u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\u3001\u30ab\u30eb\u30b8\u30aa\u30ea\u30d4\u30f3\u3001\u30ea\u30dd\u30c6\u30a4\u30b3\u9178\u3001\u307e\u305f\u306fLPS\u306b\u5bcc\u3080\uff09\u3068\u63a5\u89e6\u3059\u308b\u3068\u3001\u8fc5\u901f\u306b\u4e21\u89aa\u5a92\u6027\u03b1\u30d8\u30ea\u30c3\u30af\u30b9\u306b\u6298\u308a\u7573\u307e\u308c\u307e\u3059\u3002\u967d\u30a4\u30aa\u30f3\u9762\u304c\u9670\u30a4\u30aa\u30f3\u6027\u306e\u819c\u8868\u9762\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3001\u758e\u6c34\u9762\u304c\u8102\u8cea\u4e8c\u91cd\u5c64\u306b\u633f\u5165\u3055\u308c\u307e\u3059\u3002\u30da\u30d7\u30c1\u30c9\u5bfe\u8102\u8cea\u6bd4\u304c\u95be\u5024\u306b\u9054\u3059\u308b\u3068\u3001\u3053\u308c\u306b\u3088\u308a\u30c8\u30ed\u30a4\u30c0\u30eb\u578b\u30dd\u30a2\u307e\u305f\u306f\u300c\u30ab\u30fc\u30da\u30c3\u30c8\u300d\u69d8\u306e\u819c\u5d29\u58ca\u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u3001\u5fae\u751f\u7269\u7d30\u80de\u304c\u8131\u5206\u6975\u3057\u3001\u5fc5\u9808\u306e\u819c\u9593\u52fe\u914d\u304c\u7834\u58ca\u3055\u308c\u307e\u3059\u3002\u54fa\u4e73\u985e\u306e\u7d30\u80de\u819c\u306f\u3001\u5916\u5074\u30ea\u30fc\u30d5\u30ec\u30c3\u30c8\u304c\u53cc\u6027\u30a4\u30aa\u30f3\u6027\uff08\u30db\u30b9\u30d5\u30a1\u30c1\u30b8\u30eb\u30b3\u30ea\u30f3\u3001\u30b9\u30d5\u30a3\u30f3\u30b4\u30df\u30a8\u30ea\u30f3\uff09\u3067\u3042\u308a\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u3067\u4fdd\u8b77\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u306b\u3088\u308a\u5e83\u7bc4\u306b\u7d30\u80de\u6bd2\u6027\u3092\u6301\u3064\u754c\u9762\u6d3b\u6027\u5264\u3068\u533a\u5225\u3055\u308c\u308b\u3042\u308b\u7a0b\u5ea6\u306e\u5fae\u751f\u7269\u9078\u629e\u6027\u304c\u3082\u305f\u3089\u3055\u308c\u307e\u3059\u3002<\/li>\n<li><strong>LPS\u4e2d\u548c\u304a\u3088\u3073TLR4\u7d4c\u8def\u8abf\u7bc0<\/strong> \u2014 LL-37\u306f\u7d30\u83cc\u6027\u30ea\u30dd\u591a\u7cd6\uff08LPS\uff09\u306b\u9ad8\u3044\u89aa\u548c\u6027\u3067\u76f4\u63a5\u7d50\u5408\u3057\u3001TLR4\uff0fMD-2\uff0fCD14\u53d7\u5bb9\u4f53\u8907\u5408\u4f53\u304b\u3089LPS\u3092\u9694\u96e2\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308aLPS\u99c6\u52d5\u6027\u306eNF-\u03baB\u6d3b\u6027\u5316\u3092\u906e\u65ad\u3057\u3001\u4e0b\u6d41\u306eTNF-\u03b1\uff0fIL-6\uff0fIL-1\u03b2\u653e\u51fa\u3092\u6e1b\u5c11\u3055\u305b\u3001\u91cd\u75c7\u30b0\u30e9\u30e0\u9670\u6027\u83cc\u611f\u67d3\u6642\u306e\u6557\u8840\u75c7\u69d8\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30b9\u30c8\u30fc\u30e0\u304b\u3089\u5bbf\u4e3b\u7d44\u7e54\u3092\u4fdd\u8b77\u3057\u307e\u3059\u3002\u3053\u306e\u7279\u6027\u306b\u3088\u308a\u3001LL-37\u306fLPS\u99c6\u52d5\u6027\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u89e3\u6790\u3059\u308b\u305f\u3081\u306e\u7814\u7a76\u30c4\u30fc\u30eb\u3068\u3057\u3066\u3082\u6709\u7528\u3067\u3059\u3002<\/li>\n<li><strong>FPRL1\uff08\u30db\u30eb\u30df\u30eb\u30da\u30d7\u30c1\u30c9\u53d7\u5bb9\u4f53\u69d81\uff09\u3092\u4ecb\u3057\u305f\u514d\u75ab\u8abf\u7bc0\u3068\u4e0b\u6d41\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054<\/strong> \u2014 LL-37\u306f\u3001\u81ea\u7136\u514d\u75ab\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u7d30\u80de\u306b\u5e83\u304f\u767a\u73fe\u3059\u308bG\u30bf\u30f3\u30d1\u30af\u8cea\u5171\u5f79\u53d7\u5bb9\u4f53\u3067\u3042\u308bFPRL1\uff08FPR2\uff09\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u3001\u597d\u4e2d\u7403\u3001\u5358\u7403\u3001T\u7d30\u80de\u306b\u5bfe\u3059\u308b\u5316\u5b66\u8a98\u5f15\u7269\u8cea\u3068\u3057\u3066\u4f5c\u7528\u3057\u307e\u3059\u3002\u540c\u3058\u53d7\u5bb9\u4f53\u304c\u5185\u76ae\u7d30\u80de\u4e0a\u3067LL-37\u306e\u8840\u7ba1\u65b0\u751f\u4fc3\u9032\u4f5c\u7528\u3092\u5a92\u4ecb\u3057\u3001\u5185\u76ae\u7d30\u80de\u306e\u5897\u6b96\u3001\u904a\u8d70\u3001\u7ba1\u5f62\u6210\u3092\u523a\u6fc0\u3057\u307e\u3059\u3002\u5275\u50b7\u518d\u4e0a\u76ae\u5316\u6642\u306e\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u904a\u8d70\u3082FPRL1\u4f9d\u5b58\u6027\u3067\u3059\u3002\u3055\u3089\u306b\u3001\u3053\u306e\u30da\u30d7\u30c1\u30c9\u306f\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u4e0a\u306e\u30d7\u30ea\u30f3\u53d7\u5bb9\u4f53P2X7\u306b\u3082\u4f5c\u7528\u3057\u3001\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u8abf\u7bc0\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n<p>LL-37\u306e\u751f\u7269\u5b66\u306b\u304a\u3051\u308b\u969b\u7acb\u3063\u305f\u7279\u5fb4\u306f\u3001 <strong>\u201c\u5263\u3068\u76fe\u201d\u306e\u30d0\u30e9\u30f3\u30b9<\/strong>\uff1a \u4f4e\u6fc3\u5ea6\u3067\u306f\u3001\u3053\u306e\u30da\u30d7\u30c1\u30c9\u306f\u4e3b\u306b\u514d\u75ab\u8abf\u7bc0\u6027\u3068\u7d44\u7e54\u4fdd\u8b77\u6027\u3092\u793a\u3057\u307e\u3059\u304c\u3001\u9ad8\u6fc3\u5ea6\u3067\u306f\u76f4\u63a5\u7684\u306a\u819c\u7834\u58ca\u6d3b\u6027\u304c\u512a\u4f4d\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u6fc3\u5ea6\u4f9d\u5b58\u7684\u306a\u6a5f\u80fd\u30b9\u30a4\u30c3\u30c1\u304c\u3001LL-37\u304c\u6297\u83cc\u304a\u3088\u3073\u5275\u50b7\u6cbb\u7642\u306e\u4e21\u65b9\u306e\u9069\u5fdc\u3067\u6cbb\u7642\u7814\u7a76\u4e0a\u306e\u95a2\u5fc3\u3092\u96c6\u3081\u308b\u7406\u7531\u306e1\u3064\u3067\u3042\u308a\u3001\u3042\u3089\u3086\u308b\u30a4\u30f3\u30d3\u30c8\u30ed\u307e\u305f\u306f\u30a4\u30f3\u30d3\u30dc\u306e\u30d7\u30ed\u30c8\u30b3\u30eb\u306b\u304a\u3044\u3066\u8a73\u7d30\u306a\u7528\u91cf\u53cd\u5fdc\u7279\u6027\u306e\u89e3\u6790\u304c\u91cd\u8981\u3067\u3042\u308b\u7406\u7531\u3067\u3059\u3002<\/p>\n<h2>\u516c\u8868\u3055\u308c\u305f\u7814\u7a76\u7528\u9014<\/h2>\n<p>LL-37\u306f\u3001\u4ee5\u4e0b\u306e\u7814\u7a76\u76ee\u7684\u3067\u5b9f\u9a13\u5ba4\u7814\u7a76\u306b\u4f7f\u7528\u3055\u308c\u307e\u3059\uff1a<\/p>\n<ul>\n<li><strong>\u6297\u83cc\u85ac\u8010\u6027\u7814\u7a76<\/strong> \u2014 MRSA\u3001ESBL\u7523\u751f\u8178\u5185\u7d30\u83cc\u79d1\u7d30\u83cc\u3001\u30ab\u30eb\u30d0\u30da\u30cd\u30e0\u8010\u6027\u83cc\u3001\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u95a2\u9023\u75c5\u539f\u83cc\u306b\u5bfe\u3059\u308b\u5e83\u57df\u6700\u5c0f\u767a\u80b2\u963b\u6b62\u6fc3\u5ea6\uff08MIC\uff09\u30d1\u30cd\u30eb\uff1bAMP\u958b\u767a\u30d1\u30a4\u30d7\u30e9\u30a4\u30f3\u306e\u30d9\u30f3\u30c1\u30de\u30fc\u30ad\u30f3\u30b0<\/li>\n<li><strong>\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u7814\u7a76<\/strong> \u2014 \u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u4e88\u9632\u30a2\u30c3\u30bb\u30a4\u3001\u78ba\u7acb\u3055\u308c\u305f\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u7834\u58ca\u30a2\u30c3\u30bb\u30a4\u306b\u5bfe\u3059\u308b <em>P. aeruginosa<\/em>, <em>S. aureus<\/em>, Rosu HDL <em>K. pneumoniae<\/em> \u2014 \u56a2\u80de\u6027\u7dda\u7dad\u75c7\u304a\u3088\u3073\u6162\u6027\u5275\u50b7\u306e\u7814\u7a76\u306b\u304a\u3044\u3066\u91cd\u8981<\/li>\n<li><strong>LPS \/ \u6557\u8840\u75c7\u7814\u7a76<\/strong> \u2014 LPS\u4e2d\u548c\u30a2\u30c3\u30bb\u30a4\u3001TLR4\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u89e3\u6790\u3001\u6557\u8840\u75c7\u6027\u30b7\u30e7\u30c3\u30af\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30b9\u30c8\u30fc\u30e0\u30e2\u30c7\u30eb<\/li>\n<li><strong>\u5275\u50b7\u6cbb\u7652\u30fb\u76ae\u819a\u7814\u7a76<\/strong> \u2014 \u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u904a\u8d70\u30a2\u30c3\u30bb\u30a4\u3001\u771f\u76ae\u7dda\u7dad\u82bd\u7d30\u80de\u304a\u3088\u3073\u5185\u76ae\u7d30\u80de\u306e\u5275\u50b7\u9589\u9396\u30e2\u30c7\u30eb\uff1b\u76ae\u819a\u5275\u50b7\u6cbb\u7652\u7814\u7a76\u306b\u304a\u3051\u308b\u4e3b\u8981\u306a\u7814\u7a76\u30da\u30d7\u30c1\u30c9\u306e1\u3064<\/li>\n<li><strong>\u4e7e\u766c\u306e\u75c5\u56e0\u7814\u7a76<\/strong> \u2014 LL-37 \/ \u81ea\u5df1DNA \/ \u5f62\u8cea\u7d30\u80de\u69d8\u6a39\u72b6\u7d30\u80de\u8ef8\u306e\u89e3\u6790\uff08LL-37\u306f\u4e7e\u766c\u76ae\u819a\u3067\u904e\u5270\u767a\u73fe\u3057\u3001\u81ea\u5df1DNA\u3068\u8907\u5408\u4f53\u3092\u5f62\u6210\u3057\u3066pDC\u306eTLR9\u3092\u4ecb\u3057\u3066\u514d\u75ab\u5bdb\u5bb9\u3092\u7834\u7dbb\u3055\u305b\u308b\uff09<\/li>\n<li><strong>\u52d5\u8108\u786c\u5316\u7814\u7a76<\/strong> \u2014 \u30d7\u30e9\u30fc\u30af\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u5185\u306eLL-37\u3001\u9178\u5316LDL\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u3001\u8840\u7ba1\u708e\u75c7\u30e2\u30c7\u30eb<\/li>\n<li><strong>\u816b\u760d\u5b66\u7814\u7a76<\/strong> \u2014 \u816b\u760d\u30bf\u30a4\u30d7\u306b\u5fdc\u3058\u305f\u9006\u8aac\u7684\u306a\u816b\u760d\u4fc3\u9032\u4f5c\u7528\u3068\u6297\u816b\u760d\u4f5c\u7528\uff08LL-37\u306f\u4e00\u90e8\u306e\u304c\u3093\u3067\u306fFPRL1\u3092\u4ecb\u3057\u3066\u5897\u6b96\u4fc3\u9032\u7684\u306b\u4f5c\u7528\u3057\u3001\u4ed6\u306e\u304c\u3093\u3067\u306f\u816b\u760d\u7d30\u80de\u306e\u76f4\u63a5\u7684\u306a\u819c\u7834\u58ca\u3092\u4ecb\u3057\u3066\u6297\u816b\u760d\u7684\u306b\u4f5c\u7528\u3059\u308b\uff09<\/li>\n<li><strong>\u81ea\u7136\u514d\u75ab\u6a5f\u69cb\u7814\u7a76<\/strong> \u2014 FPRL1\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3001P2X7\u8abf\u7bc0\u3001\u597d\u4e2d\u7403\u7d30\u80de\u5916\u30c8\u30e9\u30c3\u30d7\uff08NET\uff09\u306e\u751f\u7269\u5b66\u3001\u30d3\u30bf\u30df\u30f3D\u3092\u4ecb\u3057\u305fCAMP\u8a98\u5c0e<\/li>\n<\/ul>\n<p>\u81ea\u7136\u514d\u75ab\u304a\u3088\u3073\u5bbf\u4e3b\u9632\u5fa1\u30da\u30d7\u30c1\u30c9\u7814\u7a76\u306e\u3088\u308a\u5e83\u3044\u6587\u8108\u306b\u3064\u3044\u3066\u306f\u3001\u4ee5\u4e0b\u3092\u53c2\u7167\u3057\u3066\u304f\u3060\u3055\u3044\u3002 <a href=\"https:\/\/medsbase.com\/ja\/kpv-lysine-proline-valine\/\">KPV<\/a> (\u03b1-MSH\u7531\u6765\u306e\u6297\u708e\u75c7\u30c8\u30ea\u30da\u30d7\u30c1\u30c9)\u3001, <a href=\"https:\/\/medsbase.com\/ja\/bpc-157\/\">BPC-157<\/a> (\u591a\u7d4c\u8def\u7d44\u7e54\u4fee\u5fa9\u30da\u30f3\u30bf\u30c7\u30ab\u30da\u30d7\u30c1\u30c9)\u3001\u304a\u3088\u3073 <a href=\"https:\/\/medsbase.com\/ja\/tb-500\/\">TB-500<\/a> (\u30c1\u30e2\u30b7\u30f3\u30d9\u30fc\u30bf4\u65ad\u7247\u3001\u5e45\u5e83\u3044\u7d44\u7e54\u4fee\u5fa9)\u3002\u5b8c\u5168\u7248\u3092\u898b\u308b <a href=\"https:\/\/medsbase.com\/ja\/peptides\/\">\u7814\u7a76\u7528\u30da\u30d7\u30c1\u30c9\u30ab\u30bf\u30ed\u30b0<\/a> \u5316\u5408\u7269\u9078\u629e\u306e\u305f\u3081\u306b\u3002<\/p>\n<h2>\u5229\u7528\u53ef\u80fd\u306a\u529b\u4fa1\u3068\u6fc3\u5ea6<\/h2>\n<p>MedsBase\u306f\u3001LL-37\u30925 mg\u51cd\u7d50\u4e7e\u71e5\u30d0\u30a4\u30a2\u30eb\u3067\u53d6\u308a\u6271\u3063\u3066\u3044\u307e\u3059\u300210\u30d0\u30a4\u30a2\u30eb\u5165\u308a\u307e\u305f\u306f20\u30d0\u30a4\u30a2\u30eb\u5165\u308a\u306e\u30d1\u30c3\u30af\u5f62\u5f0f\u3067\u3001\u5b8c\u5168\u306a\u518d\u6eb6\u89e3\u30ac\u30a4\u30c0\u30f3\u30b9\u4ed8\u304d\u3067\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\uff1a<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u30d0\u30a4\u30a2\u30eb\u529b\u4fa1<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u5178\u578b\u7684\u306a\u7814\u7a76\u4f7f\u7528\u4f8b<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u30d1\u30c3\u30af\u30b5\u30a4\u30ba<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>5 mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u6a19\u6e96\u7684\u306a\u7814\u7a76\u5411\u3051\u5f37\u5ea6 \u2014 \u6570\u9031\u9593\u306b\u308f\u305f\u308bMIC\u30d1\u30cd\u30eb\u3001\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u30a2\u30c3\u30bb\u30a4\u3001\u5275\u50b7\u6cbb\u7652\u5b9f\u9a13\u3001LPS\u4e2d\u548c\u30a2\u30c3\u30bb\u30a4\u3001\u514d\u75ab\u8abf\u7bc0\u7528\u91cf\u53cd\u5fdc\u8a66\u9a13<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10\u307e\u305f\u306f20\u30d0\u30a4\u30a2\u30eb<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>LL-37\u306f\u3001\u672a\u4fee\u98fe\u306e\u76f4\u9396\u72b637\u91cf\u4f53\u904a\u96e2\u9178\u3068\u3057\u3066\u4f9b\u7d66\u3055\u308c\u307e\u3059\uff08\u30a2\u30b7\u30eb\u5316\u3001PEG\u5316\u3001\u30b8\u30b9\u30eb\u30d5\u30a3\u30c9\u7d50\u5408\u306a\u3057\uff09\u3002\u30da\u30d7\u30c1\u30c9\u306f\u30d7\u30e9\u30b9\u30c1\u30c3\u30af\u306b\u5438\u7740\u3057\u3084\u3059\u3044\u305f\u3081\u3001\u7814\u7a76\u8005\u306f\u539f\u6db2\u4fdd\u7ba1\u3068\u5e0c\u91c8\u306b\u4f4e\u5438\u7740\u30c1\u30e5\u30fc\u30d6\u3092\u4f7f\u7528\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u767a\u8868\u3055\u308c\u305f\u30a2\u30c3\u30bb\u30a4\u3067\u306e\u4f5c\u696d\u6fc3\u5ea6\u306f\u3001\u8d70\u5316\u6027\u30a2\u30c3\u30bb\u30a4\u3067\u7d040.5 \u00b5g\/mL\u304b\u3089\u3001\u76f4\u63a5\u6bba\u83cc\u6297\u83cc\u30a2\u30c3\u30bb\u30a4\u3067\u6700\u5927\u7d0450 \u00b5g\/mL\u307e\u3067\u306e\u7bc4\u56f2\u3067\u3059\u3002<\/p>\n<h2>\u6bd4\u8f03\u65b9\u6cd5 \u2014 LL-37\u5bfeKPV<\/h2>\n<p>LL-37\u3068 <a href=\"https:\/\/medsbase.com\/ja\/kpv-lysine-proline-valine\/\">KPV<\/a> \u3053\u308c\u3089\u306f\u3044\u305a\u308c\u3082\u81ea\u7136\u514d\u75ab\u7814\u7a76\u3067\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u4f5c\u7528\u306e\u30b9\u30b1\u30fc\u30eb\u304c\u307e\u3063\u305f\u304f\u7570\u306a\u308a\u3001\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u306a\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3082\u7570\u306a\u308a\u307e\u3059\u3002LL-37\u306f37\u6b8b\u57fa\u304b\u3089\u306a\u308b\u5b8c\u5168\u9577\u306e\u5bbf\u4e3b\u9632\u5fa1\u30da\u30d7\u30c1\u30c9\u3067\u3042\u308a\u3001\u76f4\u63a5\u7684\u306a\u6297\u83cc\u819c\u7834\u58ca\u3068FPRL1\u3092\u4ecb\u3057\u305f\u514d\u75ab\u8abf\u7bc0\u3092\u4f75\u305b\u6301\u3061\u307e\u3059\u3002KPV\uff08\u30ea\u30b7\u30f3-\u30d7\u30ed\u30ea\u30f3-\u30d0\u30ea\u30f3\uff09\u306f\u03b1-\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u523a\u6fc0\u30db\u30eb\u30e2\u30f3\uff08\u03b1-MSH\uff09\u306eC\u672b\u7aef\u7531\u6765\u306e3\u6b8b\u57fa\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u3067\u3001\u30e1\u30e9\u30ce\u30b3\u30eb\u30c1\u30f3\u53d7\u5bb9\u4f53\u7d4c\u8def\u306e\u8abf\u7bc0\u3092\u901a\u3058\u3066\u3001\u96c6\u4e2d\u7684\u306a\u6297\u708e\u75c7\u4f5c\u7528\u3068\u5f31\u3044\u6297\u83cc\u4f5c\u7528\u3092\u793a\u3059\u30da\u30d7\u30c1\u30c9\u3067\u3059\u3002<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u8a55\u4fa1\u9805\u76ee<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">LL-37<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">KPV<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u7531\u6765<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u30d2\u30c8\u30ab\u30c6\u30ea\u30b7\u30b8\u30f3hCAP-18\uff08CAMP\u907a\u4f1d\u5b50\uff09\u306eC\u672b\u7aef<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u03b1-\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u523a\u6fc0\u30db\u30eb\u30e2\u30f3\uff08\u03b1-MSH\uff09\u306eC\u672b\u7aef<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u30a2\u30df\u30ce\u9178\u6570<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">37\u30a2\u30df\u30ce\u9178<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">3\u30a2\u30df\u30ce\u9178<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u4e3b\u306a\u4f5c\u7528\u6a5f\u5e8f<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u4e21\u89aa\u5a92\u6027\u03b1-\u30d8\u30ea\u30c3\u30af\u30b9\u819c\u7834\u58ca + FPRL1\u514d\u75ab\u8abf\u7bc0<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u30e1\u30e9\u30ce\u30b3\u30eb\u30c1\u30f3\u7d4c\u8def\u3092\u4ecb\u3057\u305f\u6297\u708e\u75c7\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\uff08NF-\u03baB\u6291\u5236\uff09<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u6297\u83cc\u30b9\u30da\u30af\u30c8\u30eb<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u5e83\u57df \u2014 \u30b0\u30e9\u30e0\u967d\u6027\u83cc\u3001\u30b0\u30e9\u30e0\u9670\u6027\u83cc\u3001\u30a8\u30f3\u30d9\u30ed\u30fc\u30d7\u30a6\u30a4\u30eb\u30b9\u3001\u771f\u83cc\u3001\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u72ed\u57df \u2014 \u4e3b\u306b\u30b0\u30e9\u30e0\u967d\u6027\u83cc\uff1bLL-37\u3088\u308a\u3082\u6570\u6841\u5f31\u3044<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u6297\u708e\u75c7\u4f5c\u7528<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u5f37\u529b\uff08LPS\u4e2d\u548c\u4f5c\u7528\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u8abf\u7bc0\u4f5c\u7528\uff09<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u5f37\u529b\uff08\u6297\u708e\u75c7\u7814\u7a76\u306e\u6a19\u6e96\u7684\u306a\u30c8\u30ea\u30da\u30d7\u30c1\u30c9\uff09<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u6b63\u5473\u96fb\u8377<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">+6\uff08\u9ad8\u3044\u30ab\u30c1\u30aa\u30f3\u6027\uff09<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">+1<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u819c\u4e2d\u3067\u306e\u69cb\u9020<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u4e21\u89aa\u5a92\u6027\u03b1-\u30d8\u30ea\u30c3\u30af\u30b9<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u660e\u78ba\u306a\u4e8c\u6b21\u69cb\u9020\u306a\u3057\uff08\u77ed\u3044\u7dda\u72b6\u30e2\u30c1\u30fc\u30d5\uff09<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u6700\u3082\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u9069\u5fdc\u75c7<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u6297\u83cc\u85ac\u8010\u6027\u3001\u5275\u50b7\u6cbb\u7652\u3001\u4e7e\u766c<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">IBD\/\u5927\u8178\u708e\u30e2\u30c7\u30eb\u3001\u8178\u306e\u708e\u75c7\u3001\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u5e83\u57df\u6297\u83cc\u6d3b\u6027\u3001\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u7834\u58ca\u3001\u307e\u305f\u306f\u819c\u5b54\u5f62\u6210\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u7126\u70b9\u3092\u5f53\u3066\u305f\u7814\u7a76\u3067\u306f\u3001LL-37\u306f\u6a19\u6e96\u7684\u306a\u53c2\u7167\u30da\u30d7\u30c1\u30c9\u3067\u3059\u3002\u30e1\u30e9\u30ce\u30b3\u30eb\u30c1\u30f3\u7d4c\u8def\u306e\u6297\u708e\u75c7\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u7126\u70b9\u3092\u5f53\u3066\u305f\u7d30\u80de\u30ec\u30d9\u30eb\u306e\u7814\u7a76\u3067\u306f\u3001, <a href=\"https:\/\/medsbase.com\/ja\/kpv-lysine-proline-valine\/\">KPV<\/a> \u306f\u3001\u3088\u308a\u9078\u629e\u7684\u306a\u30c4\u30fc\u30eb\u3067\u3059\u3002\u53c2\u7167\uff1a <a href=\"https:\/\/medsbase.com\/ja\/bpc-157\/\">BPC-157<\/a> \u7d44\u7e54\u4fee\u5fa9\u306b\u7126\u70b9\u3092\u5f53\u3066\u305f\u6297\u708e\u75c7\u7814\u7a76\u7528\u3001\u304a\u3088\u3073 <a href=\"https:\/\/medsbase.com\/ja\/tb-500\/\">TB-500<\/a> \u5e83\u7bc4\u306a\u7d44\u7e54\u4fee\u5fa9\u306e\u30d9\u30f3\u30c1\u30de\u30fc\u30af\u7528\u3002<\/p>\n<div style=\"background: #f4f8fb; border-left: 4px solid #2c7cb0; padding: 14px 18px; margin: 18px 0;\"><strong class=\"mb-bac-water-callout\">\ud83d\udca7 BAC\u6c34\u304c\u5fc5\u8981\u3067\u3059\u304b\uff1f<\/strong> \u51cd\u7d50\u4e7e\u71e5\u54c1\u306e\u5fa9\u5143\u306b\u306f\u6ec5\u83cc\u9759\u83cc\u6c34\u304c\u5fc5\u8981\u3067\u3059\u3002\u672c\u88fd\u54c1\u3068\u4f75\u305b\u3066\u5f53\u793e\u306e <a href=\"\/ja\/bac-water\/\"><strong>BAC Water\uff08\u9759\u83cc\u6c34\uff09<\/strong><\/a> \u2014 30 mL\u30de\u30eb\u30c1\u30c9\u30fc\u30ba\u30d0\u30a4\u30a2\u30eb\u30010.9%\u30d9\u30f3\u30b8\u30eb\u30a2\u30eb\u30b3\u30fc\u30eb\u4fdd\u5b58\u3001USP\u30b0\u30ec\u30fc\u30c9\u3002<\/div>\n<h2>\u4fdd\u7ba1\u65b9\u6cd5\u3068\u518d\u6eb6\u89e3<\/h2>\n<p><strong>\u518d\u6eb6\u89e3\u524d\uff1a<\/strong> \u51cd\u7d50\u4e7e\u71e5\u30d0\u30a4\u30a2\u30eb\u306f\u3001\u77ed\u671f\u4f7f\u7528\u306e\u4f5c\u696d\u7528\u30b9\u30c8\u30c3\u30af\u3068\u3057\u3066\u3001\u5143\u306e\u5305\u88c5\u306e\u307e\u307e2\uff5e8\u2103\u3067\u51b7\u8535\u4fdd\u5b58\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u9577\u671f\u4fdd\u7ba1\u306b\u306f\u3001\u672a\u958b\u5c01\u306e\u30d0\u30a4\u30a2\u30eb\u3092-20\u2103\u3067\u51b7\u51cd\u4fdd\u5b58\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u51cd\u7d50\u4e7e\u71e5\u3055\u308c\u305fLL-37\u306f\u3001\u51b7\u8535\u3067\u6700\u592724\u30f6\u6708\u3001-20\u2103\u3067\u6700\u592736\u30f6\u6708\u5b89\u5b9a\u3067\u3059\u3002\u51cd\u7d50\u4e7e\u71e5\u7c89\u672b\u306e\u51cd\u7d50\u878d\u89e3\u30b5\u30a4\u30af\u30eb\u306f\u907f\u3051\u3066\u304f\u3060\u3055\u3044\u3002\u3059\u3079\u3066\u306e\u30ab\u30c1\u30aa\u30f3\u6027\u6297\u83cc\u30da\u30d7\u30c1\u30c9\u3068\u540c\u69d8\u306b\u3001LL-37\u306f <strong>\u30d7\u30e9\u30b9\u30c1\u30c3\u30af\u5438\u7740<\/strong> \u2014 \u6a19\u6e96\u7684\u306a\u30dd\u30ea\u30d7\u30ed\u30d4\u30ec\u30f3\u30c1\u30e5\u30fc\u30d6\u3078\u306e\u308f\u305a\u304b\u306a\u5438\u7740\u3067\u3082\u3001\u7528\u91cf\u53cd\u5fdc\u30c7\u30fc\u30bf\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4f4e\u5438\u7740\u30c1\u30e5\u30fc\u30d6\uff08\u30b7\u30ea\u30b3\u30f3\u51e6\u7406\u30ac\u30e9\u30b9\u3001Protein LoBind\u3001\u307e\u305f\u306f\u30a6\u30b7\u8840\u6e05\u30a2\u30eb\u30d6\u30df\u30f3\u3067\u30d7\u30ec\u30b3\u30fc\u30c8\u3057\u305f\u30dd\u30ea\u30d7\u30ed\u30d4\u30ec\u30f3\uff09\u3092\u3001\u4fdd\u5b58\u6db2\u306e\u4fdd\u7ba1\u3084\u4f4e\u30bf\u30f3\u30d1\u30af\u8cea\u30a2\u30c3\u30bb\u30a4\u30d0\u30c3\u30d5\u30a1\u30fc\u3067\u306e\u6bb5\u968e\u5e0c\u91c8\u306b\u4f7f\u7528\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<p><strong>\u518d\u6eb6\u89e3\u624b\u9806\uff1a<\/strong> \u30d0\u30a4\u30a2\u30eb\u306e\u5074\u58c1\u306b\u6cbf\u3063\u3066\u9759\u83cc\u6c34\u3092\u6ce8\u5165\u3057\u3066\u304f\u3060\u3055\u3044\uff08\u51cd\u7d50\u4e7e\u71e5\u30b1\u30fc\u30ad\u306b\u76f4\u63a5\u304b\u3051\u306a\u3044\u3067\u304f\u3060\u3055\u3044\uff09\u30025 mg\u30d0\u30a4\u30a2\u30eb\u306e\u5834\u5408\u3001\u9759\u83cc\u6c341.0 mL\u30675 mg\/mL\u306e\u4f5c\u696d\u6fc3\u5ea6\u304c\u5f97\u3089\u308c\u307e\u3059\u30022.0 mL\u3067\u306f2.5 mg\/mL\u306e\u4f5c\u696d\u30b9\u30c8\u30c3\u30af\u304c\u5f97\u3089\u308c\u307e\u3059\u3002\u9759\u304b\u306b\u65cb\u56de\u3055\u305b\u3066\u304f\u3060\u3055\u3044\u2014\u6fc0\u3057\u304f\u30dc\u30eb\u30c6\u30c3\u30af\u30b9\u3057\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002\u6ce1\u7acb\u3061\u306b\u3088\u308a\u7a7a\u6c17\u304c\u5165\u308a\u3001\u30d8\u30ea\u30c3\u30af\u30b9\u6298\u308a\u305f\u305f\u307f\u304c\u4e71\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u7c89\u672b\u304c\u5b8c\u5168\u306b\u6eb6\u89e3\u3059\u308b\u307e\u3067\uff08\u901a\u5e381\uff5e2\u5206\uff09\u5f85\u3063\u3066\u304b\u3089\u629c\u304d\u53d6\u3063\u3066\u304f\u3060\u3055\u3044\u3002\u9759\u83cc\u5264\u306b\u611f\u53d7\u6027\u306e\u9ad8\u3044\u7528\u9014\uff08\u7d30\u80de\u57f9\u990a\u5b9f\u9a13\uff09\u3067\u306f\u3001\u6ec5\u83cc\u6c34\u307e\u305f\u306f0.01%\u9162\u9178\u3067\u6eb6\u89e3\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u6eb6\u89e3\u5f8c\u306f\u3001\u30d0\u30a4\u30a2\u30eb\u30922\uff5e8 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