{"id":71421,"date":"2026-05-20T10:30:00","date_gmt":"2026-05-20T10:30:00","guid":{"rendered":"https:\/\/medsbase.com\/5-amino-1mq\/"},"modified":"2026-05-21T07:14:08","modified_gmt":"2026-05-21T07:14:08","slug":"5-amino-1mq","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ja\/product\/5-amino-1mq\/","title":{"rendered":"5-Amino-1MQ\uff085-\u30a2\u30df\u30ce-1-\u30e1\u30c1\u30eb\u30ad\u30ce\u30ea\u30cb\u30a6\u30e0 \u30e8\u30fc\u30b8\u30c9\uff09"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background: #fff8e1; border-left: 4px solid #f5a623; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<h3 style=\"margin: 0 0 8px 0; font-size: 16px; color: #1a4a6b;\">\u30af\u30a4\u30c3\u30af\u30a2\u30f3\u30b5\u30fc \u2014 5-Amino-1MQ\u3068\u306f\uff1f<\/h3>\n<p style=\"margin: 0;\"><strong>5-Amino-1MQ<\/strong> \uff085-amino-1-methylquinolinium iodide, CAS 42464-96-0\uff09\u306f\u4f4e\u5206\u5b50\u3067\u3001\u57fa\u8cea\u90e8\u4f4d\u9078\u629e\u7684\u306a <strong>NNMT\uff08\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9-N-\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff09\u963b\u5bb3\u5264<\/strong> \u516c\u8868\u3055\u308c\u3066\u3044\u308bIC<sub>50<\/sub> \u304c1.2 \u00b5M\u3067\u3042\u308b\u3053\u3068\u3002NNMT \u2014 \u30b5\u30a4\u30c8\u30be\u30eb\u9175\u7d20\u3067\u3001\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\uff08NAD\u306e\u524d\u99c6\u4f53<sup>+<\/sup>\uff09\u304a\u3088\u3073S-\u30a2\u30c7\u30ce\u30b7\u30eb-L-\u30e1\u30c1\u30aa\u30cb\u30f3\uff08SAM\u3001\u30e6\u30cb\u30d0\u30fc\u30b5\u30eb\u30e1\u30c1\u30eb\u30c9\u30ca\u30fc\uff09 \u2014 5-Amino-1MQ\u306f\u3001\u67fb\u8aad\u4ed8\u304d\u7814\u7a76\u3067\u7d30\u80de\u5185NAD<sup>+<\/sup> \u304a\u3088\u3073SAM\u30d7\u30fc\u30eb\u3092\u5897\u52a0\u3055\u305b\u30013T3-L1\u8102\u80aa\u7d30\u80de\u306e\u8102\u80aa\u751f\u6210\u3092\u6e1b\u5c11\u3055\u305b\u3001\u98df\u4e8b\u8a98\u5c0e\u6027\u80a5\u6e80\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\uff0820 mg\/kg\/d\uff09\u3001\u7b4b\u5e79\u7d30\u80de\u4ecb\u5728\u4fee\u5fa9\u3001\u304a\u3088\u3073\u5375\u5de3\u764c\u8ee2\u79fb\u306b\u304a\u3044\u3066\u300160 mg\/kg\/d\u307e\u3067\u6709\u5bb3\u4f5c\u7528\u306a\u3057\u306b in vivo \u3067\u6709\u52b9\u6027\u3092\u793a\u3059\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u4f4e\u5206\u5b50\uff08<em>\u30da\u30d7\u30c1\u30c9\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/em>\uff09\u7814\u7a76\u7528\u306e\u51cd\u7d50\u4e7e\u71e5\u7c89\u672b\u3068\u3057\u3066\u4f9b\u7d66\u3055\u308c\u307e\u3059\u3002<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background: #f4f8fb; border: 1px solid #d8e3eb; padding: 12px 16px; margin: 16px 0; border-radius: 4px; font-size: 14px;\"><strong>MedsBase\u3067\u5f97\u3089\u308c\u308b\u3082\u306e\uff1a<\/strong> \u51cd\u7d50\u4e7e\u71e5\u54c1\u3001HPLC\u7d14\u5ea699%\u4ee5\u4e0a\u691c\u8a3c\u6e08\u307f\u7c89\u672b \u00b7 \u5206\u6790\u8a3c\u660e\u66f8\uff08COA\uff09\u306f\u3054\u8981\u671b\u306b\u5fdc\u3058\u3066\u63d0\u4f9b \u00b7 \u30d7\u30e9\u30a4\u30d0\u30b7\u30fc\u306b\u914d\u616e\u3057\u305f\u6e29\u5ea6\u5b89\u5b9a\u6027\u5305\u88c5 \u00b7 \u5168\u4e16\u754c\u5bfe\u5fdc\u306e\u7814\u7a76\u7528\u914d\u9001\u696d\u8005 \u00b7 1,400\u4ef6\u4ee5\u4e0a\u306e\u5b9f\u7e3e <a href=\"https:\/\/medsbase.com\/ja\/reviews\/\">\u30ab\u30b9\u30bf\u30de\u30fc\u30ec\u30d3\u30e5\u30fc<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size: 14px; color: #444; margin: 8px 0 18px;\">\ud83d\udce6 \u3059\u3079\u3066\u306e\u3054\u6ce8\u6587\u306f\u3001\u5f53\u5e97\u306e <a href=\"https:\/\/medsbase.com\/ja\/medsbase-re-shipment-assurance-policy\/\"><strong>\u518d\u767a\u9001\u4fdd\u8a3c\u30dd\u30ea\u30b7\u30fc<\/strong><\/a> \u2014 \u4e07\u304c\u4e00\u300120\u55b6\u696d\u65e5\u4ee5\u5185\u306b\u5546\u54c1\u304c\u5c4a\u304b\u306a\u3044\u5834\u5408\u306f\u3001\u518d\u767a\u9001\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n<table class=\"medsbase-spec-table\" style=\"width: 100%; border-collapse: collapse; margin: 18px 0; font-size: 14px;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 8px 12px; text-align: left; width: 30%;\">\u4ed5\u69d8<\/th>\n<th style=\"padding: 8px 12px; text-align: left;\">\u8a73\u7d30<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u5316\u5408\u7269\u30af\u30e9\u30b9<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u4f4e\u5206\u5b50\u7b2c\u56db\u7d1a\u30a2\u30f3\u30e2\u30cb\u30a6\u30e0\u30ad\u30ce\u30ea\u30cb\u30a6\u30e0\u5869\uff1b\u9078\u629e\u7684NNMT\u963b\u5bb3\u5264\uff1b; <em>\u30da\u30d7\u30c1\u30c9\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/em><\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u5316\u5b66\u540d<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">5-\u30a2\u30df\u30ce-1-\u30e1\u30c1\u30eb\u30ad\u30ce\u30ea\u30cb\u30a6\u30e0 \u30e8\u30a6\u5316\u7269<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>CAS\u756a\u53f7<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">42464-96-0<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u5206\u5b50\u5f0f<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">C<sub>10<\/sub>H<sub>11<\/sub>IN<sub>2<\/sub> \uff08\u30e8\u30a6\u5316\u7269\u5869\uff09<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u5206\u5b50\u91cf<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">286.11 g\/mol<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u4f5c\u7528\u6a5f\u5e8f<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u57fa\u8cea\u90e8\u4f4d\u9078\u629e\u7684\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9N-\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff08NNMT\uff09\u963b\u5bb3\u5264\uff1bIC<sub>50<\/sub> = 1.2 \u00b5M\uff08\u30a2\u30c3\u30bb\u30a4\uff1a50 \u00b5M SAM\u3001100 \u00b5M \u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\uff09\u3002\u95a2\u9023\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff08GNMT\u3001PNMT\u3001COMT\uff09\u307e\u305f\u306fNAD\u3092\u963b\u5bb3\u3057\u306a\u3044\u3002<sup>+<\/sup>-\u30b5\u30eb\u30d9\u30fc\u30b8\u9175\u7d20\uff08NAMPT\u3001NMNAT\uff09\u3002<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u914d\u5217<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u8a72\u5f53\u306a\u3057\uff08\u4f4e\u5206\u5b50\u30ad\u30ce\u30ea\u30cb\u30a6\u30e0\u5869 \u2014 \u30da\u30d7\u30c1\u30c9\u3067\u306f\u3042\u308a\u307e\u305b\u3093\uff09<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u5f62\u614b<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u51cd\u7d50\u4e7e\u71e5\u7d50\u6676\uff0f\u7c89\u672b\uff08\u30aa\u30d5\u30db\u30ef\u30a4\u30c8\uff5e\u6de1\u9ec4\u8272\uff09\uff1b\u5358\u56de\u4f7f\u7528\u306e\u7814\u7a76\u7528\u30d0\u30a4\u30a2\u30eb\u3067\u4f9b\u7d66<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u7d14\u5ea6<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u226599%\uff08HPLC\u691c\u8a3c\u6e08\u307f\u3001COA\u306f\u30ea\u30af\u30a8\u30b9\u30c8\u306b\u5fdc\u3058\u3066\u63d0\u4f9b\uff09\u2014 Sigma-Aldrich SML2832\u53c2\u7167\u30b0\u30ec\u30fc\u30c9\u306b\u4e00\u81f4<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u6eb6\u89e3\u6027<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u9ad8\u3044\u6c34\u6eb6\u6027\uff08\u7b2c\u56db\u7d1a\u30a2\u30f3\u30e2\u30cb\u30a6\u30e0\u5869\u306f\u89aa\u6c34\u6027\uff09\u3002\u9759\u83cc\u6c34\u3001\u6ec5\u83cc\u6c34\u3001\u307e\u305f\u306fPBS\u306b\u5bb9\u6613\u306b\u518d\u6eb6\u89e3\u3057\u3001\u6700\u5927\u7d0450 mg\/mL\u306e\u6fc3\u5ea6\u3067\u6c88\u6bbf\u3092\u751f\u3058\u307e\u305b\u3093\u3002\u307e\u305f\u3001DMSO\u306b\u53ef\u6eb6\u3067\u3001in vitro\u7d30\u80de\u57f9\u990a\u306e\u30b9\u30c8\u30c3\u30af\u8abf\u88fd\u306b\u4f7f\u7528\u3067\u304d\u307e\u3059\u3002<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u4fdd\u7ba1\u65b9\u6cd5<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u51cd\u7d50\u4e7e\u71e5\u54c1\uff1a2\uff5e8 \u00b0C\u3067\u77ed\u671f\u4f7f\u7528\u30b9\u30c8\u30c3\u30af\uff1b\u672a\u958b\u5c01\u30d0\u30a4\u30a2\u30eb\u306e\u9577\u671f\u4fdd\u7ba1\u306f\u221220 \u00b0C\uff08\u221220 \u00b0C\u306736\u30f6\u6708\u4ee5\u4e0a\u5b89\u5b9a\uff09\u3002\u518d\u6eb6\u89e3\u5f8c\uff1a2\uff5e8 \u00b0C\u3001\u7d0430\u65e5\u4ee5\u5185\u306b\u4f7f\u7528\u3002\u9577\u6642\u9593\u306e\u5149\u66dd\u9732\u3092\u907f\u3051\u3066\u304f\u3060\u3055\u3044\u3002\u4f5c\u696d\u6eb6\u6db2\u306e\u7e70\u308a\u8fd4\u3057\u51cd\u7d50\u878d\u89e3\u306f\u907f\u3051\u3066\u304f\u3060\u3055\u3044\u3002<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u7814\u7a76\u7528\u9014<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u5b9f\u9a13\u5ba4\u7814\u7a76\u7528\u306e\u307f\u3067\u3059\u3002\u30d2\u30c8\u307e\u305f\u306f\u52d5\u7269\u306e\u8a3a\u65ad\u30fb\u6cbb\u7642\u76ee\u7684\u306b\u306f\u4f7f\u7528\u3057\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><!-- \/medsbase-tldr-answer --><\/p>\n<h2>5-Amino-1MQ\u3068\u306f\u4f55\u3067\u3059\u304b\uff1f<\/h2>\n<p><strong>5-Amino-1MQ<\/strong> (5-\u30a2\u30df\u30ce-1-\u30e1\u30c1\u30eb\u30ad\u30ce\u30ea\u30cb\u30a6\u30e0 \u30e8\u30fc\u30b8\u30c9\u3001CAS 42464-96-0) \u306f\u3001\u4f4e\u5206\u5b50\u9078\u629e\u7684\u963b\u5bb3\u5264\u3067\u3042\u308a\u3001 <strong>\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9 N-\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff08NNMT\uff09<\/strong>, \u3001\u7d30\u80de\u8cea\u306e\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\u9175\u7d20\u3067\u3042\u308a\u3001\u305d\u306e\u751f\u7269\u5b66\u306f\u904e\u53bb10\u5e74\u306b\u308f\u305f\u308a\u3001NAD<sup>+<\/sup>-\u8ef8\u4ee3\u8b1d\u3001\u8102\u80aa\u7d30\u80de\u306e\u8102\u80aa\u65b0\u751f\u3001\u7b4b\u5e79\u7d30\u80de\u751f\u7269\u5b66\u3001\u304a\u3088\u3073\u9593\u8cea\u304c\u3093\u4ee3\u8b1d\u3092\u3064\u306a\u3050\u30ce\u30fc\u30c9\u3068\u3057\u3066\u6d6e\u4e0a\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f <em>\u30da\u30d7\u30c1\u30c9\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/em> \u2014 \u5408\u6210\u30ad\u30ce\u30ea\u30cb\u30a6\u30e0\u56db\u7d1a\u30a2\u30f3\u30e2\u30cb\u30a6\u30e0\u5869\u3067\u3042\u308a\u3001\u5206\u5b50\u5f0f\u306f C<sub>10<\/sub>H<sub>11<\/sub>IN<sub>2<\/sub> \u5206\u5b50\u91cf\u306f 286.11 g\/mol\uff08\u30e8\u30a6\u5316\u7269\u5869\u3068\u3057\u3066\uff09\u3067\u3059\u3002MedsBase\u3067\u306f\u3001\u6df7\u5408\u30d7\u30ed\u30c8\u30b3\u30eb\u7814\u7a76\u3067\u306e\u518d\u8abf\u88fd\u3068\u6295\u4e0e\u306e\u5229\u4fbf\u6027\u306e\u305f\u3081\u306b\u3001\u7814\u7a76\u7528\u30da\u30d7\u30c1\u30c9\u30ab\u30bf\u30ed\u30b0\u3068\u540c\u3058\u51cd\u7d50\u4e7e\u71e5\u30d0\u30a4\u30a2\u30eb\u5f62\u5f0f\u3067\u5728\u5eab\u3057\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n<p>NNMT \u306f\u3001\u30e1\u30c1\u30eb\u57fa\u306e\u8ee2\u79fb\u3092\u89e6\u5a92\u3057\u307e\u3059\u3002\u305d\u306e\u4f9b\u4e0e\u4f53\u306f\u3001 <strong>S-\u30a2\u30c7\u30ce\u30b7\u30eb-L-\u30e1\u30c1\u30aa\u30cb\u30f3\uff08SAM\uff09<\/strong> \u2014 \u7d30\u80de\u5185\u306e\u666e\u904d\u7684\u306a\u30e1\u30c1\u30eb\u4f9b\u4e0e\u4f53 \u2014 \u306b\u3001 <strong>\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9<\/strong>, \u30011-\u30e1\u30c1\u30eb\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\uff081-MNA\uff09\u304a\u3088\u3073S-\u30a2\u30c7\u30ce\u30b7\u30eb\u30db\u30e2\u30b7\u30b9\u30c6\u30a4\u30f3\uff08SAH\uff09\u3092\u751f\u6210\u3057\u307e\u3059\u3002\u3053\u306e\u53cd\u5fdc\u306f\u6700\u7d42\u7684\u306b\u4e21\u65b9\u306e\u57fa\u8cea\u3092\u6d88\u8cbb\u3057\u307e\u3059\uff1a\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\uff08\u901a\u5e38\u306fNAD\u306b\u518d\u30b5\u30eb\u30d9\u30fc\u30b8\u3055\u308c\u308b<sup>+<\/sup> NAMPT\u306b\u3088\u3063\u3066\uff09\u3001SAM\uff08\u901a\u5e38\u306f\u4ed6\u306e\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\u306b\u3088\u3063\u3066\u884c\u308f\u308c\u308b\u4f55\u767e\u3082\u306e\u7d30\u80de\u30e1\u30c1\u30eb\u5316\u53cd\u5fdc\u306b\u5229\u7528\u3055\u308c\u308b\uff09\u3067\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001NNMT\u306f\u6700\u3082\u7814\u7a76\u3055\u308c\u3066\u3044\u308b2\u3064\u306e\u7d30\u80de\u751f\u5316\u5b66\u8ef8\u306e\u4ea4\u70b9\u306b\u4f4d\u7f6e\u3057\u3066\u3044\u307e\u3059 \u2014 \u3059\u306a\u308f\u3061NAD<sup>+<\/sup> \u30b5\u30eb\u30d9\u30fc\u30b8\u7d4c\u8def\u30681\u70ad\u7d20\uff0f\u30e1\u30c1\u30eb\u5316\u4ee3\u8b1d \u2014 \u3067\u3042\u308a\u3001\u305d\u306e\u767a\u73fe\u306f\u80a5\u6e80\u95a2\u9023\u8102\u80aa\u7d44\u7e54\u3001\u304c\u3093\u9593\u8cea\u3001\u8001\u5316\u3057\u305f\u9aa8\u683c\u7b4b\u3067\u9855\u8457\u306b\u4e0a\u6607\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>5-Amino-1MQ\u306f\u6700\u3082\u767a\u8868\u6587\u732e\u306e\u591a\u3044 <strong>\u4f4e\u5206\u5b50\u3001\u57fa\u8cea\u90e8\u4f4d\u6a19\u7684\u578b<\/strong> NNMT\u963b\u5bb3\u5264\u3067\u3059\u3002Neelakantan\u3089\uff082017\uff5e2018\u5e74\uff09\u306b\u3088\u308a\u30011.2 \u00b5M IC<sub>50<\/sub> \u7d44\u63db\u3048NNMT\u306b\u5bfe\u3057\u3066\u3001\u95a2\u9023\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff08GNMT\u3001PNMT\u3001COMT\uff09\u3084NAD<sup>+<\/sup>-\u30b5\u30eb\u30d9\u30fc\u30b8\u9175\u7d20\uff08NAMPT\u3001NMNAT\uff09\u306b\u5bfe\u3059\u308b\u30aa\u30d5\u30bf\u30fc\u30b2\u30c3\u30c8\u6d3b\u6027\u306f\u306a\u304f\u3001\u7d4c\u53e3\u30d0\u30a4\u30aa\u30a2\u30d9\u30a4\u30e9\u30d3\u30ea\u30c6\u30a3\u306f\u3052\u3063\u6b6f\u985e\u3078\u306e\u6295\u4e0e\u30d7\u30ed\u30c8\u30b3\u30eb\u3092\u88cf\u4ed8\u3051\u308b\u306e\u306b\u5341\u5206\u3067\u3059\u3002\u305d\u306e\u5f8c\u306ein vivo\u7814\u7a76\u3067\u306f\u3001\u98df\u990c\u6027\u80a5\u6e80\u3001\u9aa8\u683c\u7b4b\u640d\u50b7\u4fee\u5fa9\u3001\u8179\u8154\u5185\u5375\u5de3\u304c\u3093\u8ee2\u79fb\u306e3\u3064\u306e\u72ec\u7acb\u3057\u305f\u75be\u60a3\u95a2\u9023\u30e2\u30c7\u30eb\u7cfb\u3067\u6d3b\u6027\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059 \u2014 \u3044\u305a\u308c\u308260 mg\/kg\/d\u307e\u3067\u306e\u7528\u91cf\u3067\u6709\u5bb3\u4f5c\u7528\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<h2>\u4f5c\u7528\u6a5f\u5e8f \u2014 NNMT\u963b\u5bb3\u3068NAD<sup>+<\/sup>\/SAM\u8ef8<\/h2>\n<p>5-Amino-1MQ\u306e\u4f5c\u7528\u6a5f\u5e8f\u306f\u3001\u767a\u8868\u6587\u732e\u306e\u4e2d\u3067\u3042\u3089\u3086\u308b\u4f4e\u5206\u5b50NNMT\u963b\u5bb3\u5264\u306e\u4e2d\u3067\u6700\u3082\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u3059\uff1a<\/p>\n<ul>\n<li><strong>\u57fa\u8cea\u90e8\u4f4d\u306b\u304a\u3051\u308bNNMT\u306e\u7af6\u5408\u7684\u963b\u5bb3<\/strong> \u2014 5-Amino-1MQ\u306fNNMT\u306e\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u57fa\u8cea\u30dd\u30b1\u30c3\u30c8\u306b\u7d50\u5408\u3057\u3001\u5929\u7136\u306e\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u57fa\u8cea\u3068\u7af6\u5408\u3057\u3066SAM\u99c6\u52d5\u306e\u30e1\u30c1\u30eb\u57fa\u8ee2\u79fb\u3092\u963b\u5bb3\u3057\u307e\u3059\u30022018\u5e74\u306b\u516c\u958b\u3055\u308c\u305f\u5171\u7d50\u6676\u69cb\u9020\u306b\u3088\u308a\u3001\u57fa\u8cea\u30c1\u30e3\u30cd\u30eb\u306e\u76f4\u63a5\u7684\u5360\u6709\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002IC<sub>50<\/sub> = 1.2 \u00b5M\uff08\u751f\u7406\u5b66\u7684\u306b\u95a2\u9023\u3059\u308b\u88dc\u56e0\u5b50\u6fc3\u5ea6\uff1a50 \u00b5M SAM\u3001100 \u00b5M \u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\uff09\u3002<\/li>\n<li><strong>NAD\u306e\u6e29\u5b58<sup>+<\/sup> \u524d\u99c6\u4f53\u30d7\u30fc\u30eb<\/strong> \u2014 NNMT\u306b\u3088\u3063\u3066\u30e1\u30c1\u30eb\u5316\u3055\u308c\u306a\u3044\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u306f\u3001NAMPT-NMNAT\u30b5\u30eb\u30d9\u30fc\u30b8\u7d4c\u8def\u3067\u5229\u7528\u53ef\u80fd\u306a\u307e\u307e\u3068\u306a\u308a\u3001\u305d\u3053\u3067NMN\u306b\u5909\u63db\u3055\u308c\u3001\u305d\u306e\u5f8cNAD\u306b\u5909\u63db\u3055\u308c\u307e\u3059\u3002<sup>+<\/sup>. NNMT\u9ad8\u767a\u73fe\u7d30\u80de\u3067\u306fNAD<sup>+<\/sup> \u67af\u6e07\u304c\u3001\u516c\u8868\u3055\u308c\u305f\u7814\u7a76\u3067\u306f5-Amino-1MQ\u6cbb\u7642\u306b\u3088\u308a\u90e8\u5206\u7684\u306b\u9006\u8ee2\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u306b\u3088\u308a\u672c\u5316\u5408\u7269\u306f\u6a5f\u69cb\u7684\u306bNAD<sup>+<\/sup> \u524d\u99c6\u4f53\uff08NMN\u3001NR\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\uff09\u306f\u3001\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u6d88\u8cbb\u901f\u5ea6\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u4e0a\u6d41\u304b\u3089\u30d7\u30fc\u30eb\u306b\u8ffd\u52a0\u3059\u308b\u3082\u306e\u3067\u3059\u3002<\/li>\n<li><strong>SAM\u30d7\u30fc\u30eb\u7bc0\u7d04\u3068\u4e0b\u6d41\u30e1\u30c1\u30eb\u5316\u52b9\u679c<\/strong> \u2014 NNMT\u304c\u89e6\u5a92\u3059\u308b\u5404\u53cd\u5fdc\u3067\u306f\u3001SAM\u5206\u5b50\u304c1\u3064\u6d88\u8cbb\u3055\u308c\u3001SAH\u304c\u751f\u6210\u3055\u308c\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001NNMT\u3092\u963b\u5bb3\u3059\u308b\u3068\u7d30\u80de\u5185SAM\u304c\u4e0a\u6607\u3057\u3001SAH\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3067\u3001SAM:SAH\u6bd4\uff08\u7d30\u80de\u306e\u30e1\u30c1\u30eb\u5316\u30dd\u30c6\u30f3\u30b7\u30e3\u30eb\uff09\u304c\u5897\u52a0\u3057\u307e\u3059\u3002\u3053\u306e\u73fe\u8c61\u306f\u3001\u516c\u8868\u3055\u308c\u3066\u3044\u308b3T3-L1\u8102\u80aa\u7d30\u80de\u306e\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u8102\u80aa\u751f\u6210\u907a\u4f1d\u5b50\u5ea7\u3067\u306e\u30d2\u30b9\u30c8\u30f3\u30e1\u30c1\u30eb\u5316\u30d1\u30bf\u30fc\u30f3\u306e\u5909\u5316\u3084\u3001de novo\u8102\u80aa\u5408\u6210\u306e\u6e1b\u5c11\u3068\u95a2\u9023\u4ed8\u3051\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<li><strong>1-\u30e1\u30c1\u30eb\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\uff081-MNA\uff09\u7523\u751f\u306e\u6e1b\u5c11<\/strong> \u2014 1-MNA\u306fNNMT\u53cd\u5fdc\u306e\u76f4\u63a5\u751f\u6210\u7269\u3067\u3059\u3002\u516c\u8868\u3055\u308c\u3066\u3044\u308b\u7814\u7a76\u3067\u306f\u30015-Amino-1MQ\u6295\u4e0e\u5f8c\u306b\u8840\u6f3f\u304a\u3088\u3073\u7d44\u7e54\u306e1-MNA\u304c\u6025\u901f\u306b\u4f4e\u4e0b\u3057\u3001\u751f\u4f53\u5185\u8a66\u9a13\u306b\u304a\u3051\u308b\u6a19\u7684\u95a2\u4e0e\u306e\u305f\u3081\u306e\u7c21\u4fbf\u306a\u85ac\u529b\u5b66\u7684\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u306a\u308a\u307e\u3059\u3002<\/li>\n<li><strong>\u9078\u629e\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb<\/strong> \u2014 5-Amino-1MQ\u306f\u3001\u95a2\u9023\u3059\u308b\u30e1\u30c1\u30eb\u57fa\u8ee2\u79fb\u9175\u7d20\u3067\u3042\u308bGNMT\uff08\u30b0\u30ea\u30b7\u30f3N-\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff09\u3001PNMT\uff08\u30d5\u30a7\u30cb\u30eb\u30a8\u30bf\u30ce\u30fc\u30eb\u30a2\u30df\u30f3N-\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff09\u3001\u307e\u305f\u306fCOMT\uff08\u30ab\u30c6\u30b3\u30fc\u30eb-O-\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff09\u3092\u963b\u5bb3\u305b\u305a\u3001\u307e\u305fNAD<sup>+<\/sup>\u30b5\u30eb\u30d9\u30fc\u30b8\u9175\u7d20\u3067\u3042\u308bNAMPT\u3084NMNAT\u3092\u59a8\u5bb3\u3057\u307e\u305b\u3093\u3002\u3053\u306e\u9078\u629e\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u304c\u30015-Amino-1MQ\u3092\u5e83\u57df\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u306e\u30e1\u30c1\u30eb\u57fa\u8ee2\u79fb\u9175\u7d20\u963b\u5bb3\u5264\u3068\u306f\u4e00\u7dda\u3092\u753b\u3057\u3001NNMT\u7279\u6709\u306e\u751f\u7269\u5b66\u3092\u89e3\u6790\u3059\u308b\u305f\u3081\u306e\u6a19\u6e96\u7684\u306a\u85ac\u7406\u5b66\u7684\u30c4\u30fc\u30eb\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n<p>\u672c\u5316\u5408\u7269\u306e\u4f5c\u7528\u306f\u3001\u3053\u308c\u3089\u306e\u751f\u5316\u5b66\u7684\u4e00\u6b21\u4f5c\u7528\u304b\u3089\u3001\u5341\u5206\u306b\u7279\u6027\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u305f\u5c11\u6570\u306e\u7d30\u80de\u8868\u73fe\u578b\u3078\u3068\u6ce2\u53ca\u3057\u307e\u3059\u3002\u3059\u306a\u308f\u3061\u30013T3-L1\u8102\u80aa\u7d30\u80de\u306e\u5206\u5316\u304a\u3088\u3073\u8102\u80aa\u751f\u6210\u306e\u6291\u5236\uff08\u6700\u3082\u5f15\u7528\u3055\u308c\u308bin vitro\u8a55\u4fa1\u9805\u76ee\uff09\u3001\u8001\u9f62\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u7b4b\u885b\u661f\u7d30\u80de\u5897\u6b96\u306e\u4fc3\u9032\u3068\u640d\u50b7\u4fee\u5fa9\u306e\u52a0\u901f\u3001\u5375\u5de3\u764c\u8ee2\u79fb\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u8179\u8154\u5185\u816b\u760d\u91cf\u306e\u6e1b\u5c11\u3067\u3059\u3002\u7814\u7a76\u8005\u306f\u3001\u7279\u5b9a\u306e\u30d7\u30ed\u30c8\u30b3\u30eb\u306b\u95a2\u9023\u3059\u308b\u7528\u91cf\u53cd\u5fdc\u3001\u52d5\u614b\u3001\u7a2e\u7279\u7570\u7684\u30d1\u30e9\u30e1\u30fc\u30bf\u306b\u3064\u3044\u3066\u3001\u4e00\u6b21\u6587\u732e\uff08Neelakantan et al. 2017\u20132019\u3001Sampath et al. 2018\u3001\u305d\u306e\u5f8c\u306eNNMT\u7d4c\u8def\u30ec\u30d3\u30e5\u30fc\uff09\u3092\u53c2\u7167\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<h2>\u516c\u8868\u3055\u308c\u305f\u7814\u7a76\u7528\u9014<\/h2>\n<p>5-Amino-1MQ\u306f\u3001\u4ee5\u4e0b\u306e\u7814\u7a76\u3092\u76ee\u7684\u3068\u3057\u305f\u5b9f\u9a13\u5ba4\u7814\u7a76\u3067\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\uff1a<\/p>\n<ul>\n<li><strong>NNMT\u8ef8\u306e\u751f\u5316\u5b66\u3068\u85ac\u7406\u5b66<\/strong> \u2014 \u7121\u7d30\u80de\u30a2\u30c3\u30bb\u30a4\u3001\u521d\u4ee3\u57f9\u990a\u7d30\u80de\u3001\u304a\u3088\u3073\u3052\u3063\u6b6f\u985e\u306ein vivo\u7814\u7a76\u306b\u304a\u3051\u308b\u9078\u629e\u7684NNMT\u963b\u5bb3\u306e\u305f\u3081\u306e\u6a19\u6e96\u7684\u306a\u85ac\u7406\u5b66\u7684\u30c4\u30fc\u30eb\u3067\u3042\u308a\u3001\u65b0\u898fNNMT\u963b\u5bb3\u5264\u9aa8\u683c\u306e\u4f5c\u7528\u6a5f\u5e8f\u7814\u7a76\u306e\u305f\u3081\u306e\u6a19\u6e96\u53c2\u7167\u5316\u5408\u7269\u3067\u3059\u3002<\/li>\n<li><strong>NAD<sup>+<\/sup>\u8ef8\u85ac\u7406\u5b66 \u2014 \u57fa\u8cea\u7bc0\u7d04\u30a2\u30d7\u30ed\u30fc\u30c1<\/strong> \u2014 NAD\u3068\u306f\u6a5f\u69cb\u7684\u306b\u7570\u306a\u308a\u307e\u3059<sup>+<\/sup>\u2014 \u524d\u99c6\u4f53\u30a2\u30d7\u30ed\u30fc\u30c1\uff08NMN\u3001NR\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u88dc\u7d66\uff09\u306f\u30d7\u30fc\u30eb\u3092\u4e0a\u304b\u3089\u5897\u3084\u3059\u306e\u306b\u5bfe\u3057\u30015-Amino-1MQ\u306f\u3080\u3057\u308dNAD\u3092\u6e1b\u5c11\u3055\u305b\u307e\u3059<sup>+<\/sup>\u2014 \u6700\u5927\u306e\u975e\u30b5\u30eb\u30d9\u30fc\u30b8\u53ef\u80fd\u306a\u30b7\u30f3\u30af\uff08NNMT\uff09\u3092\u906e\u65ad\u3059\u308b\u3053\u3068\u3067\u3001\u524d\u99c6\u4f53\u6d88\u8cbb\u3092\u4e0b\u304b\u3089\u6291\u5236\u3057\u307e\u3059<\/li>\n<li><strong>\u8102\u80aa\u7d30\u80de\u751f\u7269\u5b66\u304a\u3088\u3073\u80a5\u6e80\u7814\u7a76<\/strong> \u2014 \u98df\u4e8b\u8a98\u767a\u6027\u80a5\u6e80\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3067\u5831\u544a\u3055\u308c\u305f20 mg\/kg\/\u65e5\u306e\u6295\u4e0e\u91cf\u306f\u3001\u8102\u80aa\u91cf\u306e\u6e1b\u5c11\u3001\u8010\u7cd6\u80fd\u306e\u6539\u5584\u3001\u809d\u81d3\u8102\u8cea\u84c4\u7a4d\u306e\u4f4e\u4e0b\u3092\u3082\u305f\u3089\u3059\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u6a19\u6e96\u7684\u306a3T3-L1\u5206\u5316\u30e2\u30c7\u30eb\u3067\u306f\u8102\u80aa\u5f62\u6210\u306e\u6e1b\u5c11\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<li><strong>\u9aa8\u683c\u7b4b\u5e79\u7d30\u80de\u751f\u7269\u5b66\u3068\u52a0\u9f62\u7814\u7a76<\/strong> \u2014 \u30ab\u30eb\u30c7\u30a3\u30aa\u30c8\u30ad\u30b7\u30f3\u8a98\u767a\u6027\u7b4b\u640d\u50b7\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3067\u5831\u544a\u3055\u308c\u305f5\uff5e10 mg\/kg\u306e\u6295\u4e0e\u91cf\u306f\u3001\u7279\u306bNNMT\u767a\u73fe\u304c\u4e0a\u6607\u3057\u3066\u3044\u308b\u9ad8\u9f62\u52d5\u7269\u306b\u304a\u3044\u3066\u3001\u885b\u661f\u7d30\u80de\u306e\u5897\u6b96\u3092\u52a0\u901f\u3057\u3001\u518d\u751f\u80fd\u3092\u6539\u5584\u3059\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<li><strong>\u304c\u3093\u9593\u8cea\u4ee3\u8b1d\u7814\u7a76<\/strong> \u2014 5-Amino-1MQ\u306f\u3001\u516c\u8868\u3055\u308c\u305fHeyA8\u5375\u5de3\u764c\u8ee2\u79fb\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\uff08\u6700\u592760 mg\/kg\/\u65e5\uff09\u306e\u8179\u8154\u5185\u6295\u4e0e\u306b\u304a\u3044\u3066\u3001\u9593\u8ceaNNMT\u6d3b\u6027\u3068\u8179\u8154\u5185\u816b\u760d\u91cf\u3092\u6e1b\u5c11\u3055\u305b\u308b\u305f\u3081\u306b\u4f7f\u7528\u3055\u308c\u3066\u304a\u308a\u3001NNMT\u767a\u73fe\u304c\u9593\u8cea\u533a\u753b\u3067\u9ad8\u3044\u81b5\u81d3\u764c\u3001\u524d\u7acb\u817a\u764c\u3001\u814e\u764c\u30e2\u30c7\u30eb\u7cfb\u306b\u304a\u3051\u308b\u9593\u8cea\u6a19\u7684\u7814\u7a76\u3067\u3082\u691c\u8a0e\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<li><strong>\u30e1\u30c1\u30eb\u5316\u80fd\u3068\u4e00\u70ad\u7d20\u4ee3\u8b1d\u306e\u7814\u7a76<\/strong> \u2014 SAM:SAH\u6bd4\u3001\u5168\u30d2\u30b9\u30c8\u30f3\u30e1\u30c1\u30eb\u5316\u3001\u307e\u305f\u306fDNA\u30e1\u30c1\u30eb\u5316\u3092\u7814\u7a76\u3059\u308b\u7814\u7a76\u8005\u306f\u3001DNA\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\u3084\u30d2\u30b9\u30c8\u30f3\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\u3092\u76f4\u63a5\u963b\u5bb3\u3059\u308b\u3053\u3068\u306a\u304f\u3001\u7d30\u80de\u306e\u30e1\u30c1\u30eb\u5316\u80fd\u3092\u64b9\u4e71\u3059\u308b\u30c4\u30fc\u30eb\u3068\u3057\u30665-Amino-1MQ\u3092\u4f7f\u7528\u3067\u304d\u307e\u3059\u3002<\/li>\n<li><strong>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u751f\u4f53\u30a8\u30cd\u30eb\u30ae\u30fc\u5b66\u306e\u4f75\u7528\u7814\u7a76<\/strong> \u2014 \u30d7\u30ed\u30c8\u30b3\u30eb\u3067\u306f\u30015-Amino-1MQ\uff08NAD<sup>+<\/sup>-\u524d\u99c6\u4f53\u6e29\u5b58\uff09\u3068 <a href=\"https:\/\/medsbase.com\/ja\/nad\/\">NAD<sup>+<\/sup><\/a> \uff08\u76f4\u63a5\u524d\u99c6\u4f53\u88dc\u5145\uff09\u307e\u305f\u306f <a href=\"https:\/\/medsbase.com\/ja\/ss-31-elamipretide\/\">SS-31<\/a> \uff08\u30ab\u30eb\u30b8\u30aa\u30ea\u30d4\u30f3\u7d50\u5408\u6027\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a19\u7684\u30da\u30d7\u30c1\u30c9\uff09\u3092\u7528\u3044\u3066\u3001\u4e0a\u6d41\u57fa\u8cea\u3068\u4e0b\u6d41\u96fb\u5b50\u30d5\u30e9\u30c3\u30af\u30b9\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u751f\u4f53\u30a8\u30cd\u30eb\u30ae\u30fc\u51fa\u529b\u3078\u306e\u5bc4\u4e0e\u3092\u8abf\u3079\u308b<\/li>\n<\/ul>\n<p>NAD\u306b\u95a2\u3059\u308b\u3088\u308a\u5e83\u7bc4\u306a\u80cc\u666f\u306b\u3064\u3044\u3066\u306f\u3001<sup>+<\/sup>-\u8ef8\u304a\u3088\u3073\u672c\u30ab\u30bf\u30ed\u30b0\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\uff0f\u4ee3\u8b1d\u7814\u7a76\u7528\u5316\u5408\u7269\u306b\u3064\u3044\u3066\u306f\u3001\u3054\u53c2\u7167\u304f\u3060\u3055\u3044 <a href=\"https:\/\/medsbase.com\/ja\/nad\/\">NAD<sup>+<\/sup><\/a> \uff08\u9178\u5316\u578b\u30b8\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u88dc\u9175\u7d20\u3001\u96fb\u5b50\u4f1d\u9054\u7cfb\u306e\u4e2d\u5fc3\u7684\u57fa\u8cea\uff09\u3001, <a href=\"https:\/\/medsbase.com\/ja\/mots-c\/\">MOTS-c<\/a> \uff08\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u7531\u6765\u4ee3\u8b1d\u8abf\u7bc0\u30da\u30d7\u30c1\u30c9\uff09\u3001, <a href=\"https:\/\/medsbase.com\/ja\/ss-31-elamipretide\/\">SS-31 (Elamipretide)<\/a> \uff08\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a19\u7684\u578b\u30ab\u30eb\u30b8\u30aa\u30ea\u30d4\u30f3\u7d50\u5408\u30da\u30d7\u30c1\u30c9\uff09\u3001\u304a\u3088\u3073 <a href=\"https:\/\/medsbase.com\/ja\/l-carnitine\/\">L-\u30ab\u30eb\u30cb\u30c1\u30f3<\/a> \uff08\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u9577\u9396\u8102\u80aa\u9178\u30b7\u30e3\u30c8\u30eb\uff09\u3002\u5168 <a href=\"https:\/\/medsbase.com\/ja\/peptides\/\">\u7814\u7a76\u7528\u30da\u30d7\u30c1\u30c9\u30fb\u5316\u5408\u7269\u30ab\u30bf\u30ed\u30b0<\/a> \u95a2\u9023\u5316\u5408\u7269\u306b\u3064\u3044\u3066\u306f\u3001\u3042\u308b\u3044\u306f\u53b3\u9078\u3055\u308c\u305f <a href=\"https:\/\/medsbase.com\/ja\/best-longevity-peptides\/\">\u9577\u5bff\u7814\u7a76\u7528\u5316\u5408\u7269<\/a> KYC\uff08Know Your Customer\uff09 <a href=\"https:\/\/medsbase.com\/ja\/best-peptides-for-fat-loss\/\">\u8102\u80aa\u6e1b\u5c11\u7814\u7a76\u30da\u30d7\u30c1\u30c9<\/a> \u30cf\u30d6\u3002<\/p>\n<h2>\u5229\u7528\u53ef\u80fd\u306a\u529b\u4fa1\u3068\u6fc3\u5ea6<\/h2>\n<p>MedsBase\u3067\u306f\u30015-Amino-1MQ\u3092\u3001\u5178\u578b\u7684\u306a\u7814\u7a76\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u306e\u671f\u9593\u306b\u5408\u308f\u305b\u305f3\u7a2e\u985e\u306e\u51cd\u7d50\u4e7e\u71e5\u30d0\u30a4\u30a2\u30eb\u30b5\u30a4\u30ba\u3067\u5728\u5eab\u3057\u3066\u304a\u308a\u307e\u3059\u3002\u5404\u7528\u91cf\u306f10\u30d0\u30a4\u30a2\u30eb\u307e\u305f\u306f20\u30d0\u30a4\u30a2\u30eb\u306e\u30d1\u30c3\u30af\u5f62\u5f0f\u3067\u3054\u5229\u7528\u3044\u305f\u3060\u3051\u307e\u3059\uff1a<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u30d0\u30a4\u30a2\u30eb\u529b\u4fa1<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u5178\u578b\u7684\u306a\u7814\u7a76\u4f7f\u7528\u4f8b<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u30d1\u30c3\u30af\u30b5\u30a4\u30ba<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>5 mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">in vitro\u7d30\u80de\u57f9\u990a\u304a\u3088\u3073\u77ed\u671fin vivo\u6ef4\u5b9a \u2014 3T3-L1\u5206\u5316\u30a2\u30c3\u30bb\u30a4\u3001\u521d\u4ee3\u7d30\u80de\u85ac\u7406\u5b66\u3001\u5358\u4e00\u30b3\u30db\u30fc\u30c8\u7528\u91cf\u53cd\u5fdc\u8a66\u9a13<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10\u307e\u305f\u306f20\u30d0\u30a4\u30a2\u30eb<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>10 mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u6a19\u6e96\u7684\u306a\u4e2d\u7528\u91cf \u2014 \u98df\u4e8b\u8a98\u767a\u6027\u80a5\u6e80\u3052\u3063\u6b6f\u985ein vivo\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\uff0820 mg\/kg\/\u65e5\u30014\uff5e8\u9031\u9593\uff09\u3001\u7b4b\u640d\u50b7\u518d\u751f\u306e\u7d4c\u6642\u7684\u7814\u7a76\u3001\u4e2d\u898f\u6a21\u30b3\u30db\u30fc\u30c8\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10\u307e\u305f\u306f20\u30d0\u30a4\u30a2\u30eb<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>50 mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u30cf\u30a4\u30b9\u30eb\u30fc\u30d7\u30c3\u30c8\uff0f\u9577\u671f\u30b5\u30a4\u30af\u30eb\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb \u2014 \u5927\u898f\u6a21\u30b3\u30db\u30fc\u30c8\u4ee3\u8b1d\u7814\u7a76\u3001\u591a\u7fa4\u304c\u3093-\u9593\u8cea\u7814\u7a76\uff08HeyA8\u5375\u5de3\u304c\u3093\u30e2\u30c7\u30eb\u3067\u6700\u592760 mg\/kg\/\u65e5\uff09\u3001\u9577\u671f\u6162\u6027\u6295\u4e0e\u7814\u7a76\uff1b1mg\u3042\u305f\u308a\u306e\u6700\u4f4e\u30b3\u30b9\u30c8<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10\u307e\u305f\u306f20\u30d0\u30a4\u30a2\u30eb<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>3\u7a2e\u985e\u3059\u3079\u3066\u306e\u7528\u91cf\u306f\u540c\u4e00\u306e\u5316\u5b66\u7684\u5b9f\u4f53\uff08\u51cd\u7d50\u4e7e\u71e55-amino-1-methylquinolinium iodide\u3001HPLC\u7d14\u5ea699%\u4ee5\u4e0a\uff09\u3067\u3059\u300250 mg\u30d0\u30a4\u30a2\u30eb\u306f\u3001\u5927\u898f\u6a21\u306ain vivo\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u306b\u304a\u3044\u30661mg\u3042\u305f\u308a\u306e\u6700\u4f4e\u30b3\u30b9\u30c8\u3092\u5b9f\u73fe\u3057\u307e\u3059\uff0850 mg\u30d0\u30a4\u30a2\u30eb1\u672c\u3067\u300120 g\u306e\u30de\u30a6\u30b9\u306b\u304a\u3051\u308b20 mg\/kg\/\u65e5\u306e\u6295\u4e0e\u3067\u304a\u304a\u3088\u305d2\u9031\u9593\u5206\u3001\u307e\u305f\u306f30 g\u306e\u30e9\u30c3\u30c8\u306b\u304a\u3051\u308b60 mg\/kg\/\u65e5\u3067\u306f\u7d043\u65e5\u9593\u5206\u3092\u307e\u304b\u306a\u3048\u307e\u3059\uff09\u3002\u7814\u7a76\u8005\u306f\u3001\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u306b\u9069\u3057\u305f\u5177\u4f53\u7684\u306a\u7528\u91cf\u7bc4\u56f2\u3092\u3001\u67fb\u8aad\u4ed8\u304d\u6587\u732e\u306b\u57fa\u3065\u3044\u3066\u6c7a\u5b9a\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<h2>\u6bd4\u8f03\uff1a5-Amino-1MQ\u3068NAD<sup>+<\/sup><\/h2>\n<p>5-Amino-1MQ\u3068 <a href=\"https:\/\/medsbase.com\/ja\/nad\/\">NAD<sup>+<\/sup><\/a> \u306f\u3069\u3061\u3089\u3082NAD\u8ef8\u306e\u7814\u7a76\u7528\u5316\u5408\u7269\u3067\u3059\u304c\u3001\u540c\u3058\u4ee3\u8b1d\u30eb\u30fc\u30d7\u306e\u307e\u3063\u305f\u304f\u7570\u306a\u308b\u30dd\u30a4\u30f3\u30c8\u306b\u4ecb\u5165\u3057\u307e\u3059\u3002NAD<sup>+<\/sup> \u30b8\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u30d7\u30fc\u30eb\u3092\u76f4\u63a5\u88dc\u5145\u3057\u3001\u4e0b\u6d41\u306e\u9178\u5316\u9084\u5143\uff0f\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\uff0fPARP\u57fa\u8cea\u306e\u53ef\u7528\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3059\u308b\u5834\u5408\u306b\u6709\u7528\u3067\u3059\u30025-Amino-1MQ\u306fNNMT\u89e6\u5a92\u306b\u3088\u308b\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u306e\u6700\u7d42\u6d88\u8cbb\u3092\u963b\u5bb3\u3057\u3001NAD\u306e\u67af\u6e07\u3092\u9045\u3089\u305b\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3059\u308b\u5834\u5408\u306b\u6709\u7528\u3067\u3059\u3002<sup>+<\/sup> \u7d30\u80de\u306e\u30e1\u30c1\u30eb\u5316\u8ef8\u30af\u30ed\u30b9\u30c8\u30fc\u30af\u306b\u3088\u308b\u524d\u99c6\u4f53\u30d7\u30fc\u30eb\u3067\u3059\u3002\u3053\u308c\u30892\u3064\u306e\u5316\u5408\u7269\u306f\u30e1\u30ab\u30cb\u30ba\u30e0\u7684\u306b\u76f8\u88dc\u7684\u3067\u3042\u308a\u3001\u7814\u7a76\u30d7\u30ed\u30c8\u30b3\u30eb\u3067\u306f\u4e0a\u6d41\u57fa\u8cea\uff08NAD<sup>+<\/sup>) \u5bfe \u4e0b\u6d41\u524d\u99c6\u4f53\u6e29\u5b58\uff085-Amino-1MQ\uff09\u306eNAD\u8ef8\u51fa\u529b\u3078\u306e\u5bc4\u4e0e\u3002<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u8a55\u4fa1\u9805\u76ee<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">5-Amino-1MQ<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">NAD<sup>+<\/sup><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u5316\u5b66\u5206\u985e<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u4f4e\u5206\u5b50\u30ad\u30ce\u30ea\u30cb\u30a6\u30e0\u7b2c\u56db\u7d1a\u30a2\u30f3\u30e2\u30cb\u30a6\u30e0\u5869<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u30b8\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u88dc\u9175\u7d20\uff08\u30a2\u30c7\u30cb\u30f3\u3068\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u304c\u4e8c\u30ea\u30f3\u9178\u3092\u4ecb\u3057\u3066\u7d50\u5408\uff09<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u5206\u5b50\u91cf<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">286.11 g\/mol<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">663.43 g\/mol<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>NAD\u8ef8\u306b\u304a\u3051\u308b\u4ecb\u5165\u70b9<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">NNMT\u306b\u3088\u308b\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u6d88\u8cbb\u3092\u963b\u5bb3\uff08\u4e0b\u6d41\u304b\u3089\u306e\u524d\u99c6\u4f53\u67af\u6e07\u3092\u9045\u5ef6\uff09<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u30b8\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u30d7\u30fc\u30eb\u306b\u76f4\u63a5\u8ffd\u52a0\uff08\u4e0a\u6d41\u304b\u3089\u57fa\u8cea\u3092\u5897\u52a0\uff09<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u6700\u3082\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u7814\u7a76\u7126\u70b9<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u8102\u80aa\u7d30\u80de\u306e\u8102\u80aa\u751f\u6210\u3001\u7b4b\u885b\u661f\u7d30\u80de\u306e\u4fee\u5fa9\u3001\u764c\u9593\u8cea\u4ee3\u8b1d\u3001NNMT\u8ef8\u85ac\u7406\u5b66<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u751f\u7269\u5b66\u3001\u9577\u5bff\u3001\u7d30\u80de\u8001\u5316\u3001NAD\u8ef8\u306e\u9178\u5316\u9084\u5143\u8abf\u7bc0<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u9078\u629e\u6027<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u9ad8\u3044 \u2014 GNMT\u3001PNMT\u3001COMT\u3001NAMPT\u3001NMNAT\u3092\u963b\u5bb3\u3057\u306a\u3044<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u8a72\u5f53\u306a\u3057\uff08NAD<sup>+<\/sup> \u304c\u5929\u7136\u306e\u57fa\u8cea\u3067\u3042\u308b\uff09<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u8840\u6f3f\u4e2d\u5b89\u5b9a\u6027<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u5b89\u5b9a \u2014 \u534a\u6e1b\u671f\u306f\u6570\u6642\u9593\uff1b\u7d4c\u53e3\u3001\u8179\u8154\u5185\u3001\u9759\u8108\u5185\u6295\u4e0e\u306b\u5bfe\u5fdc<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u4e0d\u5b89\u5b9a \u2014 \u6eb6\u6db2\u4e2d\u3067\u306e\u534a\u6e1b\u671f\u306f\u6570\u5206\uff1b\u6025\u901f\u306b\u9178\u5316\u30fb\u5206\u89e3\u3059\u308b<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u4e00\u822c\u7684\u306a\u7814\u7a76\u7528\u91cf<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u516c\u8868\u30de\u30a6\u30b9\u30d7\u30ed\u30c8\u30b3\u30eb\u3067\u306f5\uff5e60 mg\/kg\/\u65e5\uff08DIO\u3067\u306f20 mg\/kg\/\u65e5\u304c\u6700\u3082\u4e00\u822c\u7684\uff1b\u6709\u5bb3\u4f5c\u7528\u306a\u3057\u3067\u8a66\u9a13\u3055\u308c\u305f\u6700\u9ad8\u7528\u91cf\u306f60 mg\/kg\/\u65e5\uff09<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u6570\u5341\u304b\u3089\u6570\u767emg\uff08\u7d30\u80de\u57f9\u990a\uff1a\u00b5M\u6fc3\u5ea6\uff09<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>FDA\u627f\u8a8d<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u3044\u3044\u3048 \u2014 \u7814\u7a76\u7528\u5316\u5408\u7269\u306e\u307f\u3067\u3059<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u3044\u3044\u3048 \u2014 \u7814\u7a76\u7528\u5316\u5408\u7269\u306e\u307f\u3067\u3059<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>NAD\u306b\u7126\u70b9\u3092\u5f53\u3066\u305f\u7814\u7a76\u3067\u306f\u3001<sup>+<\/sup>\u8ef8\u524d\u99c6\u4f53\u306eNNMT\u306b\u3088\u308b\u6d88\u8cbb\u3001\u8102\u80aa\u7d30\u80de\u306e\u8102\u80aa\u751f\u6210\u3001\u307e\u305f\u306f\u7b4b\u5e79\u7d30\u80de\u751f\u7269\u5b66\u306b\u7126\u70b9\u3092\u5f53\u3066\u305f\u7814\u7a76\u3067\u306f\u30015-Amino-1MQ\u304c\u6a19\u6e96\u7684\u306a\u85ac\u7406\u5b66\u7684\u30c4\u30fc\u30eb\u3067\u3059\u3002\u76f4\u63a5\u7684\u306aNAD\u306b\u7126\u70b9\u3092\u5f53\u3066\u305f\u7814\u7a76\u3067\u306f\u3001<sup>+<\/sup>\u30d7\u30fc\u30eb\u88dc\u5145\u3001\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u751f\u7269\u5b66\u3001\u307e\u305f\u306fNAD\u4f9d\u5b58\u6027\u306e\u9178\u5316\u9084\u5143\u8abf\u7bc0\u306b\u7126\u70b9\u3092\u5f53\u3066\u305f\u7814\u7a76\u3067\u306f\u3001, <a href=\"https:\/\/medsbase.com\/ja\/nad\/\">NAD<sup>+<\/sup><\/a> \u306f\u3088\u308a\u6a19\u7684\u3092\u7d5e\u3063\u305f\u5316\u5408\u7269\u3067\u3059\u3002\u3053\u3061\u3089\u3082\u3054\u89a7\u304f\u3060\u3055\u3044 <a href=\"https:\/\/medsbase.com\/ja\/mots-c\/\">MOTS-c<\/a> \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u7531\u6765\u306e\u30da\u30d7\u30c1\u30c9\u30b7\u30b0\u30ca\u30eb\u7814\u7a76\u7528\u3001\u304a\u3088\u3073 <a href=\"https:\/\/medsbase.com\/ja\/ss-31-elamipretide\/\">SS-31 (Elamipretide)<\/a> \u30ab\u30eb\u30b8\u30aa\u30ea\u30d4\u30f3\u7d50\u5408\u6027\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a19\u7684\u7814\u7a76\u7528\u3002<\/p>\n<div style=\"background: #f4f8fb; border-left: 4px solid #2c7cb0; padding: 14px 18px; margin: 18px 0;\"><strong class=\"mb-bac-water-callout\">\ud83d\udca7 BAC\u6c34\u304c\u5fc5\u8981\u3067\u3059\u304b\uff1f<\/strong> \u51cd\u7d50\u4e7e\u71e5\u54c1\u306e\u5fa9\u5143\u306b\u306f\u6ec5\u83cc\u9759\u83cc\u6c34\u304c\u5fc5\u8981\u3067\u3059\u3002\u672c\u88fd\u54c1\u3068\u4f75\u305b\u3066\u5f53\u793e\u306e <a href=\"\/ja\/bac-water\/\"><strong>BAC Water\uff08\u9759\u83cc\u6c34\uff09<\/strong><\/a> \u2014 30 mL\u30de\u30eb\u30c1\u30c9\u30fc\u30ba\u30d0\u30a4\u30a2\u30eb\u30010.9%\u30d9\u30f3\u30b8\u30eb\u30a2\u30eb\u30b3\u30fc\u30eb\u4fdd\u5b58\u3001USP\u30b0\u30ec\u30fc\u30c9\u3002<\/div>\n<h2>\u4fdd\u7ba1\u65b9\u6cd5\u3068\u518d\u6eb6\u89e3<\/h2>\n<p><strong>\u518d\u6eb6\u89e3\u524d\uff1a<\/strong> \u77ed\u671f\u4f7f\u7528\u306e\u30ef\u30fc\u30ad\u30f3\u30b0\u30b9\u30c8\u30c3\u30af\u3068\u3057\u3066\u3001\u51cd\u7d50\u4e7e\u71e5\u30d0\u30a4\u30a2\u30eb\u306f2\uff5e8 \u00b0C\u306e\u51b7\u8535\u3067\u3001\u5143\u306e\u5305\u88c5\u306e\u307e\u307e\u4fdd\u7ba1\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u9577\u671f\u4fdd\u5b58\u306e\u5834\u5408\u306f\u3001\u672a\u958b\u5c01\u306e\u30d0\u30a4\u30a2\u30eb\u3092\u221220 \u00b0C\u3067\u51cd\u7d50\u4fdd\u5b58\u3057\u3066\u304f\u3060\u3055\u3044\uff08\u221220 \u00b0C\u3067\u6700\u4f4e36\u304b\u6708\u9593\u5b89\u5b9a\u30012\uff5e8 \u00b0C\u3067\u6700\u4f4e12\u304b\u6708\u9593\u5b89\u5b9a\uff09\u3002\u51cd\u7d50\u4e7e\u71e55-Amino-1MQ\u306f\u3001\u5c0f\u5206\u5b50\u30ad\u30ce\u30ea\u30cb\u30a6\u30e0\u5869\u69cb\u9020\u306b\u306f\u52a0\u6c34\u5206\u89e3\u3055\u308c\u308b\u30a2\u30df\u30c9\u7d50\u5408\u3084\u30b8\u30b9\u30eb\u30d5\u30a3\u30c9\u67b6\u6a4b\u304c\u306a\u3044\u305f\u3081\u3001\u307b\u3068\u3093\u3069\u306e\u51cd\u7d50\u4e7e\u71e5\u30da\u30d7\u30c1\u30c9\u3088\u308a\u3082\u5927\u5e45\u306b\u5b89\u5b9a\u3057\u3066\u3044\u307e\u3059\u3002\u76f4\u5c04\u65e5\u5149\u306b\u9577\u6642\u9593\u3055\u3089\u3055\u306a\u3044\u3088\u3046\u4fdd\u8b77\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<p><strong>\u518d\u6eb6\u89e3\u624b\u9806\uff1a<\/strong> \u9759\u83cc\u6c34\u3001\u6ec5\u83cc\u6c34\u3001\u307e\u305f\u306f\u6ec5\u83ccPBS\u3092\u30d0\u30a4\u30a2\u30eb\u306e\u5074\u58c1\u306b\u6cbf\u3063\u3066\u6ce8\u5165\u3057\u3066\u304f\u3060\u3055\u3044\uff08\u51cd\u7d50\u4e7e\u71e5\u30b1\u30fc\u30ad\u306b\u76f4\u63a5\u304b\u3051\u306a\u3044\u3067\u304f\u3060\u3055\u3044\uff09\u30025 mg\u30d0\u30a4\u30a2\u30eb\u306e\u5834\u5408\u3001\u5e0c\u91c8\u6db21.0 mL\u30675 mg\/mL\u306e\u4f5c\u696d\u6fc3\u5ea6\u304c\u5f97\u3089\u308c\u30010.5 mL\u3067\u306f10 mg\/mL\u306b\u306a\u308a\u307e\u3059\u300210 mg\u30d0\u30a4\u30a2\u30eb\u306e\u5834\u5408\u30011.0 mL\u306710 mg\/mL\u30012.0 mL\u30675 mg\/mL\u306b\u306a\u308a\u307e\u3059\u300250 mg\u30d0\u30a4\u30a2\u30eb\u306e\u5834\u5408\u30011.0 mL\u306750 mg\/mL\uff08\u6c34\u6027\u30d0\u30c3\u30d5\u30a1\u30fc\u4e2d\u3067\u306e\u5b9f\u7528\u7684\u6eb6\u89e3\u9650\u5ea6\uff09\u30015.0 mL\u3067\u3088\u308a\u5e0c\u8584\u306a10 mg\/mL\u306e\u30ef\u30fc\u30ad\u30f3\u30b0\u30b9\u30c8\u30c3\u30af\u304c\u5f97\u3089\u308c\u307e\u3059\u30025-Amino-1MQ\u306f\u3001\u7a4f\u3084\u304b\u306b\u65cb\u56de\u3055\u305b\u308b\u3060\u3051\u3067\u975e\u5e38\u306b\u901f\u304f\u6eb6\u89e3\u3057\u307e\u3059\uff08\u901a\u5e3810\uff5e30\u79d2\u4ee5\u5185\uff09\u3002\u3053\u308c\u306f\u3001\u7b2c\u56db\u7d1a\u30a2\u30f3\u30e2\u30cb\u30a6\u30e0\u5869\u304c\u975e\u5e38\u306b\u89aa\u6c34\u6027\u304c\u9ad8\u304f\u3001\u6298\u308a\u7573\u307e\u308c\u305f\u69cb\u9020\u304c\u306a\u3044\u305f\u3081\u3067\u3059\u3002in vitro\u7d30\u80de\u57f9\u990a\u4f5c\u696d\u3067\u306f\u3001DMSO\u3082\u9069\u5207\u306a\u518d\u69cb\u6210\u6eb6\u5a92\u3067\u3059\uff08\u6700\u5927100 mM\u306e\u30b9\u30c8\u30c3\u30af\u3092\u4f5c\u6210\u53ef\u80fd\uff09\u3002\u4f7f\u7528\u76f4\u524d\u306b\u6c34\u6027\u57f9\u5730\u306b\u4f5c\u696d\u6eb6\u6db2\u3092\u5e0c\u91c8\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u6c34\u6027\u30d0\u30c3\u30d5\u30a1\u30fc\u3067\u518d\u69cb\u6210\u5f8c\u306f\u3001\u30d0\u30a4\u30a2\u30eb\u30922\uff5e8 \u00b0C\u3067\u4fdd\u7ba1\u3057\u300130\u65e5\u4ee5\u5185\u306b\u4f7f\u7528\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u5149\u304b\u3089\u4fdd\u8b77\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u6fc1\u308a\u3001\u7c92\u5b50\u72b6\u7269\u8cea\u3001\u307e\u305f\u306f\u9855\u8457\u306a\u8272\u306e\u5909\u5316\u304c\u898b\u3089\u308c\u308b\u5834\u5408\u306f\u5ec3\u68c4\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<h2>\u3088\u304f\u3042\u308b\u8cea\u554f<\/h2>\n<h3>5-Amino-1MQ\u306f\u30da\u30d7\u30c1\u30c9\u3067\u3059\u304b\uff1f<\/h3>\n<p>\u3044\u3044\u3048\u30025-Amino-1MQ\u306f\u3001\u5c0f\u5206\u5b50\u30ad\u30ce\u30ea\u30cb\u30a6\u30e0\u7b2c\u56db\u7d1a\u30a2\u30f3\u30e2\u30cb\u30a6\u30e0\u5869\uff08\u30e8\u30a6\u5316\u7269\u3068\u3057\u3066\u5206\u5b50\u91cf286.11 g\/mol\uff09\u3067\u3042\u308a\u3001, <em>\u3057\u307e\u305b\u3093<\/em> \u30da\u30d7\u30c1\u30c9\u3067\u3059\u3002\u5f53\u793e\u3067\u306f\u7814\u7a76\u7528\u30da\u30d7\u30c1\u30c9\u30ab\u30bf\u30ed\u30b0\u306b\u4e26\u3079\u3066\u5728\u5eab\u3057\u3066\u304a\u308a\u307e\u3059\u304c\u3001 <a href=\"https:\/\/medsbase.com\/ja\/nad\/\">NAD<sup>+<\/sup><\/a> KYC\uff08Know Your Customer\uff09 <a href=\"https:\/\/medsbase.com\/ja\/l-carnitine\/\">L-\u30ab\u30eb\u30cb\u30c1\u30f3<\/a> \u305d\u308c\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\/\u4ee3\u8b1d\/NAD\u8ef8\u306e\u7814\u7a76\u306b\u304a\u3044\u3066\u76f8\u88dc\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3001\u540c\u3058\u51cd\u7d50\u4e7e\u71e5\u30d0\u30a4\u30a2\u30eb\u5f62\u5f0f\u3067\u4f9b\u7d66\u3055\u308c\u308b\u305f\u3081\u3067\u3059\u3002\u3053\u306e\u305f\u3081\u3001\u4ed5\u69d8\u8868\u306e\u914d\u5217\u884c\u306b\u306f\u300cn\/a\u300d\u3068\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3>NNMT\u963b\u5bb3\u306f\u5b9f\u969b\u306b\u7d30\u80de\u5185\u3067\u4f55\u3092\u3059\u308b\u306e\u3067\u3059\u304b\uff1f<\/h3>\n<p>NNMT\uff08\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9N-\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff09\u306f\u3001\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\uff08NAD<sup>+<\/sup>\u524d\u99c6\u4f53\u306e\u5229\u7528\u53ef\u80fd\u6027\u304c\u4e0a\u6607\u3057\u307e\u3059\uff08\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u304cNAMPT-NMNAT\u306b\u3088\u308b\u30b5\u30eb\u30d9\u30fc\u30b8\u7d4c\u8def\u3067NMN\u3068NAD<sup>+<\/sup> \uff09\u3001\u305d\u3057\u3066\u7d30\u80de\u5185SAM\u304c\u4e0a\u6607\u3057\u3001SAH\u304c\u4f4e\u4e0b\u3057\u307e\u3059\uff08\u3053\u308c\u306b\u3088\u308a\u7d30\u80de\u306e\u30e1\u30c1\u30eb\u5316\u30dd\u30c6\u30f3\u30b7\u30e3\u30eb\u3001\u3059\u306a\u308f\u3061SAM:SAH\u6bd4\u304c\u4e0a\u6607\u3057\u307e\u3059\uff09\u3002\u3053\u308c\u3089\u306e2\u3064\u306e\u751f\u5316\u5b66\u7684\u4e00\u6b21\u52b9\u679c\u306f\u3001\u516c\u8868\u3055\u308c\u305f\u7814\u7a76\u3067\u5b9f\u8a3c\u3055\u308c\u305f\u7d30\u80de\u8868\u73fe\u578b\u3078\u3068\u3064\u306a\u304c\u308a\u307e\u3059\uff1a\u8102\u80aa\u7d30\u80de\u306e\u8102\u8cea\u751f\u6210\u306e\u6e1b\u5c11\u3001\u7b4b\u5e79\u7d30\u80de\u4fee\u5fa9\u306e\u4fc3\u9032\u3001\u305d\u3057\u3066\u304c\u3093\u9593\u8cea\u306e\u816b\u760d\u652f\u6301\u4ee3\u8b1d\u306e\u4f4e\u6e1b\u3067\u3059\u3002<sup>+<\/sup>\uff09\u3001\u305d\u3057\u3066\u7d30\u80de\u5185SAM\u304c\u4e0a\u6607\u3057\u3001SAH\u304c\u4f4e\u4e0b\u3057\u307e\u3059\uff08\u7d30\u80de\u306e\u30e1\u30c1\u30eb\u5316\u80fd \u2014 SAM:SAH\u6bd4 \u2014 \u3092\u9ad8\u3081\u307e\u3059\uff09\u3002\u3053\u308c\u3089\u4e8c\u3064\u306e\u751f\u5316\u5b66\u7684\u4e3b\u8981\u4f5c\u7528\u306f\u3001\u516c\u8868\u3055\u308c\u3066\u3044\u308b\u7814\u7a76\u3067\u8a18\u9332\u3055\u308c\u305f\u7d30\u80de\u8868\u73fe\u578b\u306b\u6ce2\u53ca\u3057\u307e\u3059\uff1a\u8102\u80aa\u7d30\u80de\u306e\u8102\u80aa\u751f\u6210\u306e\u6e1b\u5c11\u3001\u7b4b\u5e79\u7d30\u80de\u4fee\u5fa9\u306e\u4fc3\u9032\u3001\u764c\u9593\u8cea\u306e\u816b\u760d\u652f\u6301\u4ee3\u8b1d\u306e\u4f4e\u4e0b\u3002<\/p>\n<h3>5-Amino-1MQ\u306fNMN\u3001NR\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u3068\u3069\u306e\u3088\u3046\u306b\u7570\u306a\u308a\u307e\u3059\u304b\uff1f<\/h3>\n<p>NMN, NR, and niacinamide are all NAD<sup>+<\/sup>-\u524d\u99c6\u4f53\u5316\u5408\u7269 \u2014 \u3053\u308c\u3089\u306fNAD<sup>+<\/sup> \u30d7\u30fc\u30eb\u306b\u4e0a\u65b9\u304b\u3089\u30b5\u30eb\u30d9\u30fc\u30b8\u53ef\u80fd\u306a\u524d\u99c6\u7269\u8cea\u3092\u4f9b\u7d66\u3057\u307e\u3059\u30025-Amino-1MQ\u306f\u9006\u306e\u4f5c\u7528\u3092\u3057\u307e\u3059\uff1aNNMT\u306b\u3088\u308b\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u306e\u6700\u7d42\u6d88\u8cbb\u3092\u963b\u5bb3\u3057\u3001\u524d\u99c6\u4f53\u30d7\u30fc\u30eb\u3092\u4e0b\u65b9\u304b\u3089\u6e29\u5b58\u3057\u307e\u3059\u3002\u6a5f\u69cb\u7684\u306b\u306f\u3001\u3053\u308c\u30892\u3064\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u88dc\u5b8c\u7684\u3067\u3059 \u2014 \u516c\u8868\u3055\u308c\u305f\u4f75\u7528\u7814\u7a76\u3067\u306f\u3001\u524d\u99c6\u4f53\uff08NMN\u307e\u305f\u306fNR\uff09\u3068\u7bc0\u7d04\u5264\uff085-Amino-1MQ\uff09\u306e\u540c\u6642\u6295\u4e0e\u304c\u3001NAD<sup>+<\/sup> \u306e\u30ec\u30d9\u30eb\u306b\u53ca\u307c\u3059\u52b9\u679c\u304c\u5404\u4ecb\u5165\u5358\u72ec\u3068\u6bd4\u8f03\u3057\u3066\u76f8\u52a0\u7684\u307e\u305f\u306f\u8d85\u76f8\u52a0\u7684\u3067\u3042\u308b\u304b\u3069\u3046\u304b\u304c\u691c\u8a0e\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<h3>\u30de\u30a6\u30b9\u7814\u7a76\u3067\u4f7f\u7528\u3055\u308c\u305f\u516c\u8868\u7528\u91cf\u7bc4\u56f2\u306f\u4f55\u3067\u3059\u304b\uff1f<\/h3>\n<p>\u6700\u3082\u5f15\u7528\u3055\u308c\u3066\u3044\u308b\u30de\u30a6\u30b9\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u7528\u91cf\u306f\u3001\u98df\u4e8b\u8a98\u767a\u6027\u80a5\u6e80\u7814\u7a76\uff084\uff5e8\u9031\u9593\u306e\u9023\u65e5\u8179\u8154\u5185\u6295\u4e0e\u307e\u305f\u306f\u7d4c\u53e3\u6295\u4e0e\uff09\u306b\u304a\u3051\u308b20 mg\/kg\/\u65e5\u3067\u3059\u3002\u7b4b\u8089\u306e\u640d\u50b7\u4fee\u5fa9\u7814\u7a76\u3067\u306f5\uff5e10 mg\/kg\u304c\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002HeyA8\u5375\u5de3\u764c\u8ee2\u79fb\u7814\u7a76\u3067\u306f\u3001\u516c\u8868\u3055\u308c\u305f\u7814\u7a76\u306b\u304a\u3044\u3066\u6709\u5bb3\u4f5c\u7528\u306e\u5831\u544a\u306a\u304f\u6700\u592760 mg\/kg\/\u65e5\u304c\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7814\u7a76\u8005\u306f\u3001\u7a2e\u3001\u30e2\u30c7\u30eb\u3001\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306b\u5fdc\u3058\u305f\u6295\u4e0e\u30ac\u30a4\u30c0\u30f3\u30b9\u306b\u3064\u3044\u3066\u3001\u4e00\u6b21\u6587\u732e\uff08Neelakantan et al. 2017\u20132019\u3001Sampath et al. 2018\u3001\u305d\u306e\u5f8c\u306eNNMT\u7d4c\u8def\u306e\u30ec\u30d3\u30e5\u30fc\uff09\u3092\u53c2\u7167\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<h3>\u516c\u8868\u3055\u308c\u305f\u7814\u7a76\u3067\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u6295\u4e0e\u7d4c\u8def\u306f\u4f55\u3067\u3059\u304b\uff1f<\/h3>\n<p>\u3052\u3063\u6b6f\u985e\u306b\u304a\u3051\u308b\u8179\u8154\u5185\uff08IP\uff09\u6295\u4e0e\u306f\u3001\u4fe1\u983c\u6027\u306e\u9ad8\u3044\u5168\u8eab\u66dd\u9732\u304c\u5f97\u3089\u308c\u3001\u9023\u65e5\u53cd\u5fa9\u6295\u4e0e\u306b\u4fbf\u5229\u3067\u3042\u308b\u305f\u3081\u3001\u516c\u8868\u3055\u308c\u305f\u751f\u4f53\u5185\u7814\u7a76\u3067\u6700\u3082\u4e00\u822c\u7684\u306a\u7d4c\u8def\u3067\u3059\u3002\u7d4c\u53e3\u6295\u4e0e\uff08\u80c3\u7ba1\u6295\u4e0e\u307e\u305f\u306f\u98f2\u6599\u6c34\uff09\u3082\u6162\u6027\u6295\u4e0e\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u3067\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u76ae\u4e0b\u304a\u3088\u3073\u9759\u8108\u5185\u7d4c\u8def\u306f\u3042\u307e\u308a\u4e00\u822c\u7684\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u6587\u732e\u306b\u8a18\u8f09\u304c\u3042\u308a\u307e\u3059\u3002\u30a4\u30f3\u30d3\u30c8\u30ed\u8a66\u9a13\u3067\u306f\u3001\u5316\u5408\u7269\u3092\u57f9\u990a\u57f9\u5730\u306b\u76f4\u63a5\u30de\u30a4\u30af\u30ed\u30e2\u30eb\u6fc3\u5ea6\u3067\u6dfb\u52a0\u3057\u307e\u3059\u3002<\/p>\n<h3>5-Amino-1MQ\u306fNAD<sup>+<\/sup>, \u3001MOTS-c\u3001\u307e\u305f\u306fSS-31\u3068\u7814\u7a76\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u3067\u4f75\u7528\u3067\u304d\u307e\u3059\u304b\uff1f<\/h3>\n<p>\u306f\u3044 \u2014 \u3053\u308c\u30894\u3064\u306e\u5316\u5408\u7269\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304a\u3088\u3073NAD\u8ef8\u751f\u7269\u5b66\u306e\u7570\u306a\u308b\u5c64\u3092\u6a19\u7684\u3068\u3057\u3066\u304a\u308a\u3001\u4e0a\u6d41\u57fa\u8cea\u5bfe\u4e0b\u6d41\u96fb\u5b50\u30d5\u30e9\u30c3\u30af\u30b9\u5bfe\u30ab\u30eb\u30b8\u30aa\u30ea\u30d4\u30f3\/\u5185\u819c\u69cb\u9020\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u51fa\u529b\u3078\u306e\u5bc4\u4e0e\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u7814\u7a76\u3067\u4e00\u822c\u7684\u306b\u7d44\u307f\u5408\u308f\u305b\u3066\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306f\u6eb6\u6db2\u4e2d\u3067\u4e00\u7dd2\u306b\u5316\u5b66\u7684\u306b\u5b89\u5b9a\u3067\u3059\u3002\u305d\u308c\u305e\u308c\u3092\u6700\u521d\u306b\u5225\u3005\u306b\u518d\u69cb\u6210\u3057\u3066\u5b89\u5b9a\u6027\u3068\u6fc3\u5ea6\u306e\u6b63\u78ba\u6027\u3092\u78ba\u8a8d\u3057\u3001\u305d\u306e\u5f8c\u3001\u518d\u69cb\u6210\u3057\u305f\u30d0\u30a4\u30a2\u30eb\u3092\u4e00\u7dd2\u306b\u4fdd\u5b58\u3059\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u4f7f\u7528\u76f4\u524d\u306b\u6df7\u548c\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u516c\u8868\u6587\u732e\u3067\u6700\u3082\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u7d44\u307f\u5408\u308f\u305b\u306f5-Amino-1MQ\u3068NAD\u3067\u3059<sup>+<\/sup> \u524d\u8ff0\u306e\u524d\u99c6\u4f53\uff08NMN\u307e\u305f\u306fNR\uff09; \u30da\u30d7\u30c1\u30c9\u5316\u5408\u7269\u3068\u306e\u7d44\u307f\u5408\u308f\u305b\u306f\u767a\u8868\u304c\u5c11\u306a\u3044\u3082\u306e\u306e\u3001\u6a5f\u69cb\u7684\u306b\u306f\u5408\u7406\u7684\u3067\u3059\u3002<\/p>\n<h3>5-Amino-1MQ\u304cFDA\u627f\u8a8d\u3055\u308c\u3066\u3044\u306a\u3044\u306e\u306f\u306a\u305c\u3067\u3059\u304b\uff1f<\/h3>\n<p>5-Amino-1MQ\u306f\u6bd4\u8f03\u7684\u6700\u8fd1\u306e\u7814\u7a76\u30c4\u30fc\u30eb\u5316\u5408\u7269\u3067\u3042\u308a\uff08\u57fa\u8cea\u90e8\u4f4d\u9078\u629e\u6027\u306f2017\u5e74\u306bNeelakantan\u3089\u306b\u3088\u308a\u521d\u3081\u3066\u5831\u544a\u3055\u308c\u307e\u3057\u305f\uff09\u3001\u3053\u308c\u307e\u3067\u306b\u30d2\u30c8\u81e8\u5e8a\u958b\u767a\u306b\u5165\u3063\u3066\u3044\u307e\u305b\u3093\u3002NNMT\u963b\u5bb3\u85ac\u306e\u5206\u91ce\u306f\u5275\u85ac\u521d\u671f\u6bb5\u968e\u3067\u6d3b\u767a\u306b\u7814\u7a76\u3055\u308c\u3066\u304a\u308a\u3001\u3044\u304f\u3064\u304b\u306e\u7b2c2\u4e16\u4ee3NNMT\u963b\u5bb3\u85ac\u9aa8\u683c\u304c\u524d\u81e8\u5e8a\u958b\u767a\u4e2d\u3067\u3059\u304c\u3001\u3053\u306e\u30af\u30e9\u30b9\u306e\u5316\u5408\u7269\u3067\u30d2\u30c8\u81e8\u5e8a\u8a66\u9a13\u3092\u5b8c\u4e86\u3057\u305f\u3082\u306e\u306f\u307e\u3060\u3042\u308a\u307e\u305b\u3093\u30025-Amino-1MQ\u306f\u3001\u5b9f\u9a13\u5ba4\u7814\u7a76\u306b\u304a\u3051\u308b\u9078\u629e\u7684NNMT\u963b\u5bb3\u306e\u305f\u3081\u306e\u6700\u3082\u767a\u8868\u3055\u308c\u305f\u53c2\u7167\u30c4\u30fc\u30eb\u3068\u3057\u3066\u6b8b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3>5-Amino-1MQ\u306e\u9078\u629e\u6027\u306f\u3001\u3088\u308a\u5e83\u7bc4\u306a\u30b9\u30da\u30af\u30c8\u30eb\u306e\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\u963b\u5bb3\u5264\u3068\u3069\u306e\u3088\u3046\u306b\u6bd4\u8f03\u3055\u308c\u307e\u3059\u304b\uff1f<\/h3>\n<p>5-Amino-1MQ\u306f\u57fa\u8cea\u90e8\u4f4d\u3092\u6a19\u7684\u3068\u3057\u305f\u963b\u5bb3\u5264\u3067\u3001NNMT\u306e\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u57fa\u8cea\u30dd\u30b1\u30c3\u30c8\u306b\u7d50\u5408\u3057\u3001SAM\u88dc\u56e0\u5b50\u30dd\u30b1\u30c3\u30c8\u306b\u306f\u95a2\u4e0e\u3057\u307e\u305b\u3093\u3002\u3053\u308c\u306fSAM\u7af6\u5408\u578b\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\u963b\u5bb3\u5264\uff08\u30b7\u30cd\u30d5\u30a1\u30f3\u30ae\u30f3\u3084\u30e1\u30c1\u30eb\u30c1\u30aa\u30a2\u30c7\u30ce\u30b7\u30f3\u985e\u4f3c\u4f53\u306a\u3069\uff09\u3068\u306f\u6a5f\u69cb\u7684\u306b\u7570\u306a\u308a\u3001\u3053\u308c\u3089\u306f\u88dc\u56e0\u5b50\u30dd\u30b1\u30c3\u30c8\u3092\u6a19\u7684\u3068\u3059\u308b\u305f\u3081\u3001\u5e83\u7bc4\u56f2\u306e\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\u3092\u963b\u5bb3\u3057\u307e\u3059\u3002\u57fa\u8cea\u90e8\u4f4d\u3092\u6a19\u7684\u3068\u3059\u308b\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u3088\u308a\u30015-Amino-1MQ\u306fGNMT\u3001PNMT\u3001COMT\u306a\u3069\u306e\u4ed6\u306eSAM\u4f9d\u5b58\u6027\u9175\u7d20\u306b\u5bfe\u3057\u3066\u9078\u629e\u6027\u3092\u793a\u3057\u3001\u6c4e\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\u963b\u5bb3\u5264\u3068\u3057\u3066\u3067\u306f\u306a\u304f\u3001NNMT\u7279\u7570\u7684\u306a\u751f\u7269\u5b66\u3092\u89e3\u6790\u3059\u308b\u30c4\u30fc\u30eb\u3068\u3057\u3066\u6709\u7528\u3067\u3059\u3002<\/p>\n<div class=\"medsbase-trust-strip\" style=\"background: #f4f8fb; border: 1px solid #d8e3eb; padding: 12px 16px; margin: 20px 0 8px; border-radius: 4px; font-size: 14px;\"><strong>MedsBase\u304b\u3089\u7814\u7a76\u7528\u5316\u5408\u7269\u3092\u6ce8\u6587\u3059\u308b\u7406\u7531\uff1a<\/strong> \u51cd\u7d50\u4e7e\u71e5\u54c1 HPLC\u7d14\u5ea699%\u4ee5\u4e0a\u306e\u30da\u30d7\u30c1\u30c9\u304a\u3088\u3073\u5316\u5408\u7269 \u00b7 \u5206\u6790\u8a3c\u660e\u66f8\uff08COA\uff09\u306f\u3054\u8981\u671b\u306b\u5fdc\u3058\u3066\u63d0\u4f9b \u00b7 \u6e29\u5ea6\u5909\u5316\u306b\u5f37\u3044\u3001\u4e2d\u8eab\u306e\u308f\u304b\u3089\u306a\u3044\u68b1\u5305 \u00b7 \u56fd\u969b\u5b85\u914d\u4fbf \u00b7 <a href=\"https:\/\/medsbase.com\/ja\/medsbase-re-shipment-assurance-policy\/\">\u518d\u767a\u9001\u4fdd\u8a3c<\/a> \u5168\u3066\u306e\u3054\u6ce8\u6587\u306b \u00b7 1,400\u4ef6\u4ee5\u4e0a\u306e\u78ba\u8a8d\u6e08\u307f <a href=\"https:\/\/medsbase.com\/ja\/reviews\/\">\u30ab\u30b9\u30bf\u30de\u30fc\u30ec\u30d3\u30e5\u30fc<\/a><\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>NAD\u8ef8\u304a\u3088\u3073\u4ee3\u8b1d\u7814\u7a76\u5411\u3051\u306e\u305d\u306e\u4ed6\u306e\u7814\u7a76\u7528\u5316\u5408\u7269<\/h2>\n<ul>\n<li><a href=\"\/ja\/nad\/\"><strong>NAD\u207a<\/strong><\/a> \u2014 \u9178\u5316\u578b\u30b8\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u88dc\u9175\u7d20 \u2014 NAD\u30d7\u30fc\u30eb\u76f4\u63a5\u88dc\u5145\u7814\u7a76\u7528<\/li>\n<li><a href=\"\/ja\/mots-c\/\"><strong>MOTS-c<\/strong><\/a> \u2014 \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u7531\u6765\u30da\u30d7\u30c1\u30c9 \u2014 \u4ee3\u8b1d\u304a\u3088\u3073\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u7814\u7a76\u7528<\/li>\n<li><a href=\"\/ja\/ss-31-elamipretide\/\"><strong>SS-31 (Elamipretide)<\/strong><\/a> \u2014 \u30ab\u30eb\u30b8\u30aa\u30ea\u30d4\u30f3\u7d50\u5408\u6027\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a19\u7684\u30da\u30d7\u30c1\u30c9<\/li>\n<li><a href=\"\/ja\/epitalon\/\"><strong>Epitalon<\/strong><\/a> \u2014 \u677e\u679c\u4f53\u8ef8\u30c6\u30c8\u30e9\u30da\u30d7\u30c1\u30c9\u30d0\u30a4\u30aa\u30ec\u30ae\u30e5\u30ec\u30fc\u30bf\u30fc \u2014 \u30c6\u30ed\u30e1\u30e9\u30fc\u30bc\uff0f\u9577\u5bff\u7814\u7a76\u7528<\/li>\n<li><a href=\"\/ja\/l-carnitine\/\"><strong>L-\u30ab\u30eb\u30cb\u30c1\u30f3<\/strong><\/a> \u2014 \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u9577\u9396\u8102\u80aa\u9178\u30b7\u30e3\u30c8\u30eb \u2014 \u4f75\u7528\u4f4e\u5206\u5b50<\/li>\n<li><a href=\"\/ja\/bac-water\/\"><strong>BAC Water\uff08\u9759\u83cc\u6c34\uff09<\/strong><\/a> \u2014 \u5168\u3066\u306e\u51cd\u7d50\u4e7e\u71e5\u30d0\u30a4\u30a2\u30eb\u306e\u518d\u6eb6\u89e3\u306b\u5fc5\u8981 \u2014 \u7121\u83cc\u30010.9%\u30d9\u30f3\u30b8\u30eb\u30a2\u30eb\u30b3\u30fc\u30eb\u4fdd\u5b58\u5e0c\u91c8\u6db2<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 \u9078\u629e\u7684\u5c0f\u5206\u5b50NNMT\uff08\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9N-\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff09\u963b\u5bb3\u5264<br \/>\n\u2705 \u57fa\u8cea\u90e8\u4f4d\u6a19\u7684\u578b\uff1bIC\u2085\u2080 1.2 \u00b5M\uff1bGNMT\/PNMT\/COMT\/NAMPT\/NMNAT\u306b\u4f5c\u7528\u3057\u306a\u3044<br \/>\n\u2705 \u524d\u99c6\u4f53\u6d88\u8cbb\u306e\u7bc0\u7d04\u306b\u3088\u308a\u7d30\u80de\u5185NAD\u207a\u30fbSAM\u30d7\u30fc\u30eb\u3092\u5897\u52a0<br \/>\n\u2705 3T3-L1\u8102\u80aa\u7d30\u80de\u306e\u8102\u8cea\u751f\u6210\u3092\u6291\u5236\uff1bDIO\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3067\u6d3b\u6027\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b<br \/>\n\u2705 \u5c0f\u5206\u5b50\u7814\u7a76\u7528\u5316\u5408\u7269 \u2014 \u30da\u30d7\u30c1\u30c9\u3067\u306f\u3042\u308a\u307e\u305b\u3093\uff08\u5206\u5b50\u91cf 286.11\u3001CAS 42464-96-0\uff09<\/p>\n<p><strong>5-Amino-1MQ<\/strong> 5-amino-1-methylquinolinium 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