{"id":71441,"date":"2026-05-20T11:35:00","date_gmt":"2026-05-20T11:35:00","guid":{"rendered":"https:\/\/medsbase.com\/hmg-peptide\/"},"modified":"2026-05-21T07:14:08","modified_gmt":"2026-05-21T07:14:08","slug":"hmg-peptide","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ja\/product\/hmg-peptide\/","title":{"rendered":"HMG\uff08\u30d2\u30c8\u9589\u7d4c\u671f\u30b4\u30ca\u30c9\u30c8\u30ed\u30d4\u30f3\uff0f\u30e1\u30ce\u30c8\u30ed\u30d4\u30f3\uff09\u2014 \u7814\u7a76\u7528\u30b0\u30ec\u30fc\u30c9"},"content":{"rendered":"

<\/p>\n

\n

\u30af\u30a4\u30c3\u30af\u30a2\u30f3\u30b5\u30fc \u2014 HMG\uff08\u7814\u7a76\u7528\uff09\u3068\u306f\u4f55\u3067\u3059\u304b\uff1f<\/h3>\n

HMG<\/strong> (\u30d2\u30c8\u9589\u7d4c\u671f\u30b4\u30ca\u30c9\u30c8\u30ed\u30d4\u30f3\u3001\u5225\u540d \u30e1\u30ce\u30c8\u30ed\u30d4\u30f3<\/strong>; CAS 61489-71-2\uff09\u306f\u3001LH\u3068FSH\u306e\u751f\u7269\u6d3b\u6027\u3092\u7b49\u91cf\u542b\u3080\u5c3f\u7531\u6765\u306e\u7cd6\u30bf\u30f3\u30d1\u30af\u30db\u30eb\u30e2\u30f3\u88fd\u5264\u3067\u3059\uff081\u30d0\u30a4\u30a2\u30eb\u3042\u305f\u308a75 IU LH + 75 IU FSH\u3001\u6a19\u6e96\u7684\u306a1:1\u6bd4\u7387\uff09\u3002\u9589\u7d4c\u5f8c\u5973\u6027\u306e\u5c3f\u304b\u3089\u7cbe\u88fd\u3055\u308c\u305f\u3082\u306e\u3067 \u2014 \u4e0b\u5782\u4f53\u6027\u30b4\u30ca\u30c9\u30c8\u30ed\u30d4\u30f3\u5206\u6ccc\u304c\u30cd\u30ac\u30c6\u30a3\u30d6\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u6291\u5236\u306e\u6b20\u5982\u306b\u3088\u308a\u81ea\u7136\u306b\u4e0a\u6607\u3057\u3066\u3044\u308b \u2014 hMG\u306f\u3001\u53e4\u5178\u7684\u306a LHCGR\u3068FSHR\u306e\u4e8c\u91cd\u30a2\u30b4\u30cb\u30b9\u30c8<\/strong> \u5185\u5206\u6ccc\u85ac\u7406\u5b66\u306b\u304a\u3044\u3066\u3001\u305d\u3057\u3066\u3001\u30e9\u30a4\u30c7\u30a3\u30c3\u30d2\u7d30\u80de\uff0f\u83a2\u819c\u7d30\u80de\u3067\u306e\u30b9\u30c6\u30ed\u30a4\u30c9\u7523\u751f\uff08LH\u5074\uff09\u3068\u30bb\u30eb\u30c8\u30ea\u7d30\u80de\uff0f\u9846\u7c92\u819c\u7d30\u80de\u3067\u306e\u4f5c\u7528\uff08FSH\u5074\uff09\u3092\u540c\u6642\u306b\u5fc5\u8981\u3068\u3059\u308b\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u306e\u305f\u3081\u306e\u53c2\u7167\u7814\u7a76\u30c4\u30fc\u30eb\u3067\u3059\u3002\u63d0\u4f9b\u3055\u308c\u308b\u7814\u7a76\u30b0\u30ec\u30fc\u30c9\u306e\u6750\u6599\u306f\u3001HPLC\u7d14\u5ea699%\u4ee5\u4e0a\u306e\u5c3f\u62bd\u51fa\u7cd6\u578b\u3067\u3059\u3002 \u7814\u7a76\u7528\u306b\u9650\u308a\u307e\u3059\u3002<\/em> \u81e8\u5e8a\u7528\u306e\u30e1\u30ce\u30c8\u30ed\u30d4\u30f3\u88fd\u5264\uff08Menopur\u3001Menogon\u3001Repronex\uff09\u3068\u306f\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n<\/div>\n

MedsBase\u3067\u5f97\u3089\u308c\u308b\u3082\u306e\uff1a<\/strong> \u51cd\u7d50\u4e7e\u71e5 HPLC\u7d14\u5ea699%\u4ee5\u4e0a\u78ba\u8a8d\u6e08\u307f\u5c3f\u62bd\u51fahMG \u00b7 COA\u306f\u3054\u8981\u671b\u306b\u5fdc\u3058\u3066\u63d0\u4f9b\u53ef\u80fd \u00b7 \u4e2d\u8eab\u304c\u308f\u304b\u3089\u306a\u3044\u6e29\u5ea6\u5b89\u5b9a\u68b1\u5305 \u00b7 \u5168\u4e16\u754c\u7814\u7a76\u7528\u914d\u9001 \u00b7 1,400\u4ef6\u4ee5\u4e0a\u306e\u691c\u8a3c\u6e08\u307f \u30ab\u30b9\u30bf\u30de\u30fc\u30ec\u30d3\u30e5\u30fc<\/a><\/div>\n

\ud83d\udce6 \u3059\u3079\u3066\u306e\u3054\u6ce8\u6587\u306f\u3001\u5f53\u5e97\u306e \u518d\u767a\u9001\u4fdd\u8a3c\u30dd\u30ea\u30b7\u30fc<\/strong><\/a> \u2014 \u4e07\u304c\u4e00\u300120\u55b6\u696d\u65e5\u4ee5\u5185\u306b\u5546\u54c1\u304c\u5c4a\u304b\u306a\u3044\u5834\u5408\u306f\u3001\u518d\u767a\u9001\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u4ed5\u69d8<\/th>\n\u8a73\u7d30<\/th>\n<\/tr>\n<\/thead>\n
\u5316\u5408\u7269\u30af\u30e9\u30b9<\/strong><\/td>\n\u7cd6\u30bf\u30f3\u30d1\u30af\u30db\u30eb\u30e2\u30f3\u88fd\u5264 \u2014 LH\u3068FSH\u306e\u751f\u7269\u6d3b\u6027\u306e1\uff1a1\u56fa\u5b9a\u6df7\u5408\u7269\uff1bLH\/CG\u53d7\u5bb9\u4f53\uff08LHCGR\uff09\u3068FSH\u53d7\u5bb9\u4f53\uff08FSHR\uff09\u306e\u4e8c\u91cd\u30a2\u30b4\u30cb\u30b9\u30c8\uff1b\u30da\u30d7\u30c1\u30c9\u30db\u30eb\u30e2\u30f3\u88fd\u5264<\/td>\n<\/tr>\n
\u5316\u5b66\u540d<\/strong><\/td>\n\u30d2\u30c8\u9589\u7d4c\u671f\u30b4\u30ca\u30c9\u30c8\u30ed\u30d4\u30f3\uff08\u30e1\u30ce\u30c8\u30ed\u30d4\u30f3\uff1b\u5c3f\u62bd\u51fa\u88fd\u5264\uff1b\u5225\u540d\uff1ahMG\u3001urofollitropin-with-LH\u3001\u9589\u7d4c\u671f\u30b4\u30ca\u30c9\u30c8\u30ed\u30d4\u30f3\uff09<\/td>\n<\/tr>\n
CAS\u756a\u53f7<\/strong><\/td>\n61489-71-2\uff08\u30e1\u30ce\u30c8\u30ed\u30d4\u30f3\uff0fhMG\u6df7\u5408\u88fd\u5264\uff09<\/td>\n<\/tr>\n
\u6709\u52b9\u6210\u5206<\/strong><\/td>\nLH<\/strong> \uff08\u9ec4\u4f53\u5f62\u6210\u30db\u30eb\u30e2\u30f3\u3001\u7d0430 kDa\u306e\u30d8\u30c6\u30ed\u4e8c\u91cf\u4f53\uff1b\u03b1\u30b5\u30d6\u30e6\u30cb\u30c3\u30c892\u30a2\u30df\u30ce\u9178 + \u03b2\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8121\u30a2\u30df\u30ce\u9178\u3001\u7cd6\u9396\u4fee\u98fe\uff09 \u2014 1\u30d0\u30a4\u30a2\u30eb\u3042\u305f\u308a75 IU\uff1b; FSH<\/strong> \uff08\u5375\u80de\u523a\u6fc0\u30db\u30eb\u30e2\u30f3\u3001\u7d0430 kDa\u306e\u30d8\u30c6\u30ed\u4e8c\u91cf\u4f53\uff1b\u03b1\u30b5\u30d6\u30e6\u30cb\u30c3\u30c892\u30a2\u30df\u30ce\u9178 + \u03b2\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8111\u30a2\u30df\u30ce\u9178\u3001\u7cd6\u9396\u4fee\u98fe\uff09 \u2014 1\u30d0\u30a4\u30a2\u30eb\u3042\u305f\u308a75 IU\u3002\u03b1\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u306fLH\u3001FSH\u3001HCG\u3001TSH\u306e\u9593\u3067\u5171\u901a\u3067\u3042\u308a\u3001\u03b2\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u304c\u53d7\u5bb9\u4f53\u7279\u7570\u6027\u3092\u4ed8\u4e0e\u3057\u307e\u3059\u3002\u4e21\u65b9\u306e\u30b4\u30ca\u30c9\u30c8\u30ed\u30d4\u30f3\u306f\u3001\u5e83\u7bc4\u306bN-\u304a\u3088\u3073O-\u30b0\u30ea\u30b3\u30b7\u30eb\u5316\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/td>\n<\/tr>\n
\u751f\u7269\u6d3b\u6027\u6bd4<\/strong><\/td>\nLH:FSH\u6d3b\u6027\u6bd4 = 1:1\uff081990\u5e74\u4ee3\u5f8c\u534a\u306e\u529b\u4fa1\u6a19\u6e96\u5316\u4ee5\u964d\u306e\u6a19\u6e96\u7684\u306ahMG\u6bd4\u3002\u4e21\u6d3b\u6027\u306fWHO\u30d0\u30a4\u30aa\u30a2\u30c3\u30bb\u30a4\u306b\u3088\u308a\u56fd\u969b\u53c2\u7167\u6a19\u6e96\u306b\u5bfe\u3057\u3066\u6e2c\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\uff09<\/td>\n<\/tr>\n
HCG\u5171\u7cbe\u88fd\uff08\u7814\u7a76\u95a2\u9023\uff09<\/strong><\/td>\n\u5c3f\u7531\u6765hMG\u88fd\u5264\u306e\u7279\u5fb4\uff1a\u516c\u8868\u3055\u308c\u305f\u7d44\u6210\u5206\u6790\u3067\u306f\u3001\u7d04 \u751f\u4f53\u5185LH\u53d7\u5bb9\u4f53\u4ecb\u5728\u6027\u751f\u7269\u6d3b\u6027\u306e95%\u306f\u3001\u9589\u7d4c\u5f8c\u5c3f\u304b\u3089\u5171\u7cbe\u88fd\u3055\u308c\u305f\u5fae\u91cf\u306eHCG\u306b\u8d77\u56e0\u3057\u307e\u3059\u3002<\/strong> \uff08Wolfenson et al. 2005 \u4ed6\uff09\u3002HCG\u3068LH\u306f\u540c\u3058LHCGR\u306b\u540c\u69d8\u306e\u89aa\u548c\u6027\u3067\u7d50\u5408\u3057\u307e\u3059\u304c\u3001HCG\u306e\u534a\u6e1b\u671f\u306f33\uff5e37\u6642\u9593\u3067\u3042\u308b\u306e\u306b\u5bfe\u3057\u3001LH\u306e\u534a\u6e1b\u671f\u306f\u7d0420\u5206\u3067\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u5fae\u91cf\u306eHCG\u3067\u3082\u751f\u4f53\u5185LH\u76f8\u5f53\u30b7\u30b0\u30ca\u30eb\u3092\u652f\u914d\u3057\u307e\u3059\u3002\u7814\u7a76\u8005\u306f\u3001hMG\u3092\u7d14\u7c8b\u306a\u907a\u4f1d\u5b50\u7d44\u63db\u3048LH\uff08Luveris\uff09\u88fd\u5264\u3068\u6bd4\u8f03\u3059\u308b\u969b\u306b\u3001\u3053\u306e\u70b9\u306b\u7559\u610f\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/td>\n<\/tr>\n
\u4f5c\u7528\u6a5f\u5e8f<\/strong><\/td>\n\u4e8c\u91cdGPCR\u30a2\u30b4\u30cb\u30ba\u30e0\u3002 LHCGR<\/strong> \uff08Gs\u5171\u5f79\u3001\u30e9\u30a4\u30c7\u30a3\u30c3\u30d2\u7d30\u80de\uff0f\u83a2\u819c\u7d30\u80de\uff0f\u9846\u7c92\u819c\u7d30\u80de\uff0f\u9ec4\u4f53\u7d30\u80de\uff09\u2192 cAMP-PKA-StAR-CYP17A1\u30ab\u30b9\u30b1\u30fc\u30c9 \u2192 \u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u751f\u5408\u6210\u3002 FSHR<\/strong> \uff08Gs\u5171\u5f79\u3001\u7537\u6027\u3067\u306f\u30bb\u30eb\u30c8\u30ea\u7d30\u80de\uff0f\u5973\u6027\u3067\u306f\u9846\u7c92\u819c\u7d30\u80de\uff09\u2192 cAMP-PKA-CYP19A1\/\u30a2\u30ed\u30de\u30bf\u30fc\u30bc\u30ab\u30b9\u30b1\u30fc\u30c9 \u2192 \u7cbe\u5b50\u5f62\u6210\u652f\u6301\uff08\u7537\u6027\uff09\u307e\u305f\u306f\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u304b\u3089\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u3078\u306e\u5909\u63db\uff0b\u5375\u80de\u6210\u719f\uff08\u5973\u6027\uff09\u3002\u3053\u306e\u4e8c\u91cd\u6d3b\u6027\u5316\u304c\u3001hMG\u3092\u7d14\u7c8bLH\uff08Luveris\uff0frLH\uff09\u3084\u7d14\u7c8bFSH\uff08Gonal-F\uff0fPuregon\uff0frFSH\uff09\u88fd\u5264\u3068\u533a\u5225\u3059\u308b\u70b9\u3067\u3059\u3002<\/td>\n<\/tr>\n
\u914d\u5217<\/strong><\/td>\n\u6df7\u5408\u88fd\u5264 \u2014 LH\u3068FSH\u306f\u3069\u3061\u3089\u3082\u30d8\u30c6\u30ed\u4e8c\u91cf\u4f53\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u3002\u03b1\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\uff08\u5171\u901a\uff09\u306f\u7d0492\u30a2\u30df\u30ce\u9178\u3067\u3001LH\/FSH\/HCG\/TSH\u9593\u3067\u540c\u4e00\u3067\u3059\u3002LH \u03b2\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u306f\u7d04121\u30a2\u30df\u30ce\u9178\u3001FSH \u03b2\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u306f\u7d04111\u30a2\u30df\u30ce\u9178\u3067\u3059\u3002\u5b8c\u5168\u306a\u914d\u5217\u306fUniProt\u304b\u3089\u5165\u624b\u53ef\u80fd\u3067\u3059\uff1aLH\u03b2\uff08P01229\uff09\u3001FSH\u03b2\uff08P01225\uff09\u3001GPH\u03b1\uff08P01215\uff09\u3002<\/td>\n<\/tr>\n
\u5206\u5b50\u5f0f<\/strong><\/td>\n\u5c3f\u7531\u6765\u6df7\u5408\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u88fd\u5264 \u2014 FSH\uff08\u03b1 92aa + \u03b2 111aa\uff09\u3068LH\uff08\u03b1 92aa + \u03b2 121aa\uff09\u306e\u30d8\u30c6\u30ed\u4e8c\u91cf\u4f53\u304c\u3001\u751f\u7269\u6d3b\u6027\u6bd4\u7d041:1\u3067\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u88fd\u5264\u5168\u4f53\u306b\u308f\u305f\u308b\u4e0d\u5747\u4e00\u306a\u30b0\u30ea\u30b3\u30b7\u30eb\u5316\u30d1\u30bf\u30fc\u30f3\u306e\u305f\u3081\u3001\u5358\u4e00\u306e\u5206\u5b50\u5f0f\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/td>\n<\/tr>\n
\u8840\u6f3f\u4e2d\u534a\u6e1b\u671f<\/strong><\/td>\nFSH\u6d3b\u6027\uff1a\u7d42\u672b\u534a\u6e1b\u671f\u306f\u7d0430\uff5e40\u6642\u9593\uff08\u30b7\u30a2\u30eb\u9178\u4fee\u98fe\u306b\u4f9d\u5b58\u3057\u3001\u4ed6\u306e\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u30db\u30eb\u30e2\u30f3\u3068\u540c\u69d8\uff09\u3002hMG\u4e2d\u306eLH\u6d3b\u6027\uff1a\u540d\u76ee\u4e0a\u306f\u7d0410\uff5e20\u6642\u9593\uff08\u305f\u3060\u3057\u5b9f\u969b\u306b\u306f\u3001\u5171\u7cbe\u88fd\u3055\u308c\u305fHCG\u753b\u5206\u306e\u534a\u6e1b\u671f33\uff5e37\u6642\u9593\u306b\u4f9d\u5b58\u3057\u307e\u3059 \u2014 \u4e0a\u8a18\u306eHCG\u5171\u7cbe\u88fd\u306b\u95a2\u3059\u308b\u6ce8\u8a18\u3092\u53c2\u7167\uff09\u3002<\/td>\n<\/tr>\n
\u5f62\u614b<\/strong><\/td>\n\u30de\u30f3\u30cb\u30c8\u30fc\u30eb\u307e\u305f\u306f\u30e9\u30af\u30c8\u30fc\u30b9\u3092\u5b89\u5b9a\u5316\u57fa\u5264\u3068\u3059\u308b\u767d\u8272\uff5e\u5fae\u9ec4\u767d\u8272\u306e\u51cd\u7d50\u4e7e\u71e5\u975e\u6676\u8cea\u7c89\u672b\u3067\u3001\u7814\u7a76\u7528\u5358\u56de\u4f7f\u7528\u30d0\u30a4\u30a2\u30eb\u5165\u308a\u3067\u3059\u3002<\/td>\n<\/tr>\n
\u7d14\u5ea6<\/strong><\/td>\n\u226599%\uff08HPLC\u691c\u8a3c\u6e08\u307f\uff09\uff1bWHO\u30d0\u30a4\u30aa\u30a2\u30c3\u30bb\u30a4\u306b\u3088\u308a\u3001\u8868\u793a\u901a\u308a\u306eLH\u304a\u3088\u3073FSH\u6d3b\u6027\uff08\u540475 IU\uff09\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5206\u6790\u8a3c\u660e\u66f8\uff08COA\uff09\u306f\u3054\u8981\u671b\u306b\u5fdc\u3058\u3066\u63d0\u4f9b\u53ef\u80fd\u3067\u3059\u3002<\/td>\n<\/tr>\n
\u6eb6\u89e3\u6027<\/strong><\/td>\n\u30d0\u30a4\u30a2\u30eb\u3042\u305f\u308a1.0 mL\u306e\u9759\u83cc\u6c34\u3067\u6eb6\u89e3 \u2192 75 IU LH + 75 IU FSH\/mL\u306e\u4f5c\u696d\u539f\u6db2\uff1b\u305d\u306e\u4ed6\u306e\u5e0c\u91c8\u306f\u30d7\u30ed\u30c8\u30b3\u30eb\u306b\u5f93\u3063\u3066\u304f\u3060\u3055\u3044\u3002\u30b1\u30fc\u30ad\u306f\u7a4f\u3084\u304b\u306b\u65cb\u56de\u3055\u305b\u308b\u3053\u3068\u3067\u901f\u3084\u304b\u306b\u6eb6\u89e3\u3057\u307e\u3059\u3002 \u632f\u3068\u3046\u3057\u306a\u3044\u3067\u304f\u3060\u3055\u3044\uff1b\u30dc\u30eb\u30c6\u30c3\u30af\u30b9\u3057\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002<\/strong> \u2014 \u9ad8\u526a\u65ad\u6df7\u5408\u306f\u3001LH\u304a\u3088\u3073FSH\u6210\u5206\u306e\u03b1\/\u03b2\u30d8\u30c6\u30ed\u4e8c\u91cf\u4f53\u3092\u89e3\u96e2\u3055\u305b\u307e\u3059\u3002<\/td>\n<\/tr>\n
\u4fdd\u7ba1\u65b9\u6cd5<\/strong><\/td>\n\u51cd\u7d50\u4e7e\u71e5\u54c1\uff1a\u672a\u958b\u5c01\u3067\u77ed\u671f\u4f5c\u696d\u7528\u306b\u306f2\uff5e8 \u00b0C\uff1b\u9577\u671f\u4fdd\u5b58\u306b\u306f\u221220 \u00b0C\uff08\u221220 \u00b0C\u306736\u304b\u6708\u4ee5\u4e0a\u5b89\u5b9a\uff1b2\uff5e8 \u00b0C\u306718\u304b\u6708\u4ee5\u4e0a\u5b89\u5b9a\uff09\u3002\u6eb6\u89e3\u5f8c\uff1a2\uff5e8 \u00b0C\u3067\u7d0430\u65e5\u4ee5\u5185\u306b\u4f7f\u7528\u3002\u5149\u304b\u3089\u4fdd\u8b77\u3057\u3066\u304f\u3060\u3055\u3044\u3002 \u6eb6\u89e3\u5f8c\u306e\u6750\u6599\u3092\u51cd\u7d50\u3057\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002<\/strong> \u2014 \u51cd\u7d50\u878d\u89e3\u30b5\u30a4\u30af\u30eb\u306f\u3001LH\u304a\u3088\u3073FSH\u306e\u03b1\/\u03b2\u30d8\u30c6\u30ed\u4e8c\u91cf\u4f53\u3092\u89e3\u96e2\u3055\u305b\u3001\u751f\u7269\u6d3b\u6027\u3092\u7834\u58ca\u3057\u307e\u3059\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u7528\u9014<\/strong><\/td>\n\u7814\u7a76\u7528\u306e\u307f\u3002\u30d2\u30c8\u307e\u305f\u306f\u52d5\u7269\u306e\u8a3a\u65ad\u30fb\u6cbb\u7642\u76ee\u7684\u306b\u306f\u4f7f\u7528\u3067\u304d\u307e\u305b\u3093\u3002hMG\/\u30e1\u30ce\u30c8\u30ed\u30d4\u30f3\u306f\u4e16\u754c\u30a2\u30f3\u30c1\u30fb\u30c9\u30fc\u30d4\u30f3\u30b0\u6a5f\u69cb\uff08WADA\uff09\u306e\u7981\u6b62\u8868\uff08\u30af\u30e9\u30b9S2\u3001\u30da\u30d7\u30c1\u30c9\u30db\u30eb\u30e2\u30f3\u3001\u6210\u9577\u56e0\u5b50\u304a\u3088\u3073\u95a2\u9023\u7269\u8cea\uff09\u306b\u63b2\u8f09\u3055\u308c\u3066\u304a\u308a\u3001\u7537\u6027\u30a2\u30b9\u30ea\u30fc\u30c8\u306b\u5bfe\u3057\u3066\u5e38\u306b\u7981\u6b62\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30d2\u30c8\u3092\u5bfe\u8c61\u3068\u3059\u308b\u7814\u7a76\u306b\u643a\u308f\u308b\u7814\u7a76\u8005\u306f\u3001\u3053\u306e\u898f\u5236\u72b6\u6cc1\u3092\u8a8d\u8b58\u3057\u3066\u304a\u304f\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/p>\n

HMG\uff08\u30e1\u30ce\u30c8\u30ed\u30d4\u30f3\uff09\u3068\u306f\u4f55\u3067\u3059\u304b\uff1f<\/h2>\n

HMG<\/strong> \u2014 \u30d2\u30c8\u9589\u7d4c\u671f\u30b4\u30ca\u30c9\u30c8\u30ed\u30d4\u30f3\u3001\u5225\u540d \u30e1\u30ce\u30c8\u30ed\u30d4\u30f3<\/strong> \uff08CAS 61489-71-2\uff09\u306f\u3001\u9589\u7d4c\u5f8c\u5973\u6027\u306e\u30d7\u30fc\u30eb\u5c3f\u304b\u3089\u30a4\u30aa\u30f3\u4ea4\u63db\u304a\u3088\u3073\u30b2\u30eb\u308d\u904e\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\u306b\u3088\u308a\u7cbe\u88fd\u3055\u308c\u305f\u3001LH\uff08\u9ec4\u4f53\u5f62\u6210\u30db\u30eb\u30e2\u30f3\uff09\u3068FSH\uff08\u5375\u80de\u523a\u6fc0\u30db\u30eb\u30e2\u30f3\uff09\u306e\u751f\u7269\u6d3b\u6027\u304c\u7b49\u91cf\u542b\u307e\u308c\u308b\u5c3f\u7531\u6765\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u30db\u30eb\u30e2\u30f3\u88fd\u5264\u3067\u30011\u30d0\u30a4\u30a2\u30eb\u3042\u305f\u308a\u540475 IU\u306b\u6a19\u6e96\u5316\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u9589\u7d4c\u306b\u4f34\u3046\u5375\u5de3\u306e\u8ca0\u306e\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u6291\u5236\u306e\u55aa\u5931\u306b\u3088\u308a\u3001\u4e0b\u5782\u4f53\u6027\u817a\u523a\u6fc0\u30db\u30eb\u30e2\u30f3\u306e\u5206\u6ccc\u304c\u81ea\u7136\u306b\u4ea2\u9032\u3057\u3066\u3044\u308b\u9589\u7d4c\u5f8c\u5973\u6027\uff08LH\u304a\u3088\u3073FSH\u306f\u901a\u5e38\u540450\uff5e100 mIU\/mL\u4ee5\u4e0a\uff09\u306e\u5c3f\u304b\u3089\u7cbe\u88fd\u3055\u308c\u307e\u3059\u3002<\/p>\n

\u540d\u79f0\u4e2d\u306e\u300c\u9589\u7d4c\u671f\u300d\u306f\u3053\u306e\u4f9b\u7d66\u6e90\u3092\u6307\u3057\u3066\u3044\u307e\u3059\u3002\u9589\u7d4c\u5f8c\u5973\u6027\u306e\u5c3f\u306f\u3001\u5de5\u696d\u7684\u898f\u6a21\u306e\u7cbe\u88fd\u306b\u5229\u7528\u53ef\u80fd\u306aLH\u304a\u3088\u3073FSH\u306e\u6700\u3082\u6fc3\u7e2e\u3055\u308c\u305f\u5929\u7136\u4f9b\u7d66\u6e90\u3067\u3042\u308a\u3001hMG\u306f1960\u5e74\u4ee3\u521d\u982d\u304b\u3089\u3053\u306e\u4f9b\u7d66\u6e90\u3092\u7528\u3044\u3066\u88fd\u9020\u3055\u308c\u3066\u304d\u307e\u3057\u305f\uff08\u6700\u521d\u306eCesare Serono\u304c\u958b\u767a\u3057\u305fPergonal\u88fd\u5264\uff09\u3002hMG\u306e\u7d44\u6210\u306e\u6539\u826f\u306f\u6570\u5341\u5e74\u306b\u308f\u305f\u308a\u5927\u304d\u304f\u9032\u6b69\u3057\u3001\u521d\u671f\u306e\u88fd\u5264\u3067\u306fLH:FSH\u6bd4\u304c\u5927\u304d\u304f\u5909\u52d5\u3057\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u4e0d\u7d14\u7269\u3082\u591a\u304f\u542b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u73fe\u5728\u306e\u88fd\u5264\uff08\u5f53\u793e\u306e\u7814\u7a76\u7528\u30b0\u30ec\u30fc\u30c9\u306e\u539f\u6599\u306e\u57fa\u76e4\uff09\u306f\u30011\u30d0\u30a4\u30a2\u30eb\u3042\u305f\u308a75:75 IU\u306e\u751f\u7269\u6d3b\u6027\u306b\u6a19\u6e96\u5316\u3055\u308c\u3001HPLC\u7d14\u5ea699%\u4ee5\u4e0a\u3092\u9054\u6210\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

hMG\u306f\u3001\u6a19\u6e96\u7684\u306a\u4e8c\u91cd\u751f\u817a\u523a\u6fc0\u30db\u30eb\u30e2\u30f3\u306e\u85ac\u7406\u5b66\u7684\u30c4\u30fc\u30eb\u3067\u3059\u3002HCG\u304c\u9078\u629e\u7684\u306bLHCGR\u3092\u6d3b\u6027\u5316\u3057\u3001\u7d14\u7c8b\u306aLH\uff08\u907a\u4f1d\u5b50\u7d44\u63db\u3048Luveris\uff09\u304c\u751f\u7406\u5b66\u7684\u534a\u6e1b\u671f\u3067\u9078\u629e\u7684\u306bLHCGR\u3092\u6d3b\u6027\u5316\u3057\u3001\u7d14\u7c8b\u306aFSH\uff08\u907a\u4f1d\u5b50\u7d44\u63db\u3048Gonal-F \/ Puregon\uff09\u304c\u9078\u629e\u7684\u306bFSHR\u3092\u6d3b\u6027\u5316\u3059\u308b\u306e\u306b\u5bfe\u3057\u3001hMG\u306f\u4e21\u65b9\u306e\u53d7\u5bb9\u4f53\u3092\u56fa\u5b9a\u3055\u308c\u305f1:1\u306e\u6bd4\u7387\u3067\u540c\u6642\u306b\u6d3b\u6027\u5316\u3057\u307e\u3059\u3002\u3053\u308c\u30892\u3064\u306e\u53d7\u5bb9\u4f53\u306f\u3001\u751f\u6b96\u817a\u5185\u306e\u7570\u306a\u308b\u7d30\u80de\u96c6\u56e3\u306b\u767a\u73fe\u3057\u3066\u3044\u307e\u3059 \u2014 LHCGR\u306f\u30e9\u30a4\u30c7\u30a3\u30c3\u30d2\u7d30\u80de\/\u83a2\u819c\u7d30\u80de\/\u9ec4\u4f53\u5316\u9846\u7c92\u819c\u7d30\u80de\/\u9ec4\u4f53\u306b\u3001FSHR\u306f\u30bb\u30eb\u30c8\u30ea\u7d30\u80de\/\u58c1\u9846\u7c92\u819c\u7d30\u80de\u306b \u2014 \u305d\u306e\u305f\u3081\u3001\u4e8c\u91cd\u6d3b\u6027\u5316\u306f\u3001\u3044\u305a\u308c\u304b\u306e\u53d7\u5bb9\u4f53\u3060\u3051\u3092\u6d3b\u6027\u5316\u3059\u308b\u3088\u308a\u3082\u3001\u5185\u56e0\u6027\u306e\u5468\u671f\u4e2d\u671f\u306e\u4e0b\u5782\u4f53\u5206\u6ccc\u306b\u3088\u308a\u8fd1\u3044\u3001\u5b8c\u5168\u306a\u751f\u7406\u5b66\u7684\u6027\u817a\u523a\u6fc0\u30db\u30eb\u30e2\u30f3\u523a\u6fc0\u3092\u3082\u305f\u3089\u3057\u307e\u3059\u3002<\/p>\n

\u7814\u7a76\u306b\u95a2\u9023\u3059\u308b\u30cb\u30e5\u30a2\u30f3\u30b9\uff1aHCG\u306e\u5171\u7cbe\u88fd\u3002<\/strong> \u5c3f\u7531\u6765hMG\u88fd\u5264\u306e\u516c\u958b\u3055\u308c\u305f\u7d44\u6210\u5206\u6790\u306b\u3088\u308b\u3068\u3001in vivo\u306b\u304a\u3051\u308bLH\u53d7\u5bb9\u4f53\u306e\u751f\u7269\u6d3b\u6027\u306e\u5927\u90e8\u5206\u306f\u3001\u5b9f\u969b\u306b\u306f\u9589\u7d4c\u5f8c\u5973\u6027\u306e\u5c3f\u304b\u3089\u5171\u7cbe\u88fd\u3055\u308c\u305f\u5fae\u91cf\u306eHCG\u306b\u8d77\u56e0\u3057\u3001\u4e00\u90e8\u306e\u5206\u6790\u3067\u306fLH\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u305f\u751f\u7269\u6d3b\u6027\u306e\u7d0495%\u306b\u53ca\u3076\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08Wolfenson et al., 2005\uff09\u3002\u3053\u308c\u306f\u3001HCG\u3068LH\u304c\u540c\u3058LHCGR\u306b\u985e\u4f3c\u3057\u305f\u89aa\u548c\u6027\u3067\u7d50\u5408\u3059\u308b\u3082\u306e\u306e\u3001HCG\u306e\u8840\u6f3f\u4e2d\u534a\u6e1b\u671f\u304c33\uff5e37\u6642\u9593\u3067\u3042\u308b\u306e\u306b\u5bfe\u3057\u3001LH\u306f\u7d0420\u5206\u3067\u3042\u308b\u305f\u3081\u3001\u5c11\u91cf\u306eHCG\u3067\u3082\u7d2f\u7a4d\u7684\u306ain vivo LH\u7b49\u4fa1\u30b7\u30b0\u30ca\u30eb\u306b\u304a\u3044\u3066\u652f\u914d\u7684\u3068\u306a\u308b\u304b\u3089\u3067\u3059\u3002\u3053\u308c\u304c\u3001hMG\u304c\u3001LH\u81ea\u4f53\u306e\u540d\u76ee\u4e0a\u306e\u300cLH\u6d3b\u6027\u300d\u306f\u77ed\u6642\u9593\u3067\u3042\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u6301\u7d9a\u7684\u306a\u30e9\u30a4\u30c7\u30a3\u30c3\u30d2\u7d30\u80de\u523a\u6fc0\u3092\u3082\u305f\u3089\u3059\u7406\u7531\u306e\u4e00\u90e8\u3067\u3059\u3002\u3053\u306e\u533a\u5225\u304c\u91cd\u8981\u306a\u7814\u7a76\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\uff08\u7d14\u7c8b\u306aLH\u85ac\u7406\u5b66\u3068HCG\u6c5a\u67d3\u3055\u308c\u305f\u6df7\u5408LH\u30b7\u30b0\u30ca\u30eb\uff09\u3067\u306f\u3001\u907a\u4f1d\u5b50\u7d44\u63db\u3048LH\uff08Luveris\uff09\u304c\u3088\u308a\u30af\u30ea\u30fc\u30f3\u306a\u30c4\u30fc\u30eb\u3068\u306a\u308a\u307e\u3059\u3002\u751f\u7406\u5b66\u7684\u306a1:1\u6bd4\u3067\u306eLHCGR + FSHR\u306e\u4e8c\u91cd\u6d3b\u6027\u5316\u3092\u76ee\u6a19\u3068\u3059\u308b\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u3067\u306f\u3001hMG\u304c\u6a19\u6e96\u7684\u306a\u53c2\u7167\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n

\u4f5c\u7528\u6a5f\u5e8f \u2014 LHCGR + FSHR \u306e\u4e8c\u91cd\u6d3b\u6027\u5316<\/h2>\n

hMG\u306e\u4f5c\u7528\u6a5f\u5e8f\u306f\u3001\u5185\u5206\u6ccc\u85ac\u7406\u5b66\u3067\u5341\u5206\u306b\u89e3\u660e\u3055\u308c\u3066\u3044\u308b2\u3064\u306e\u69cb\u6210\u6d3b\u6027\u306e\u4e8c\u91cd\u306e\u7dcf\u548c\u3067\u3059\u3002<\/p>\n