{"id":71484,"date":"2026-05-20T10:05:00","date_gmt":"2026-05-20T10:05:00","guid":{"rendered":"https:\/\/medsbase.com\/pnc-27\/"},"modified":"2026-05-21T07:14:09","modified_gmt":"2026-05-21T07:14:09","slug":"pnc-27","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ja\/product\/pnc-27\/","title":{"rendered":"PNC-27\uff08p53-HDM2\u819c\u6a19\u7684\u5316\u30ad\u30e1\u30e9\u30da\u30d7\u30c1\u30c9\uff09"},"content":{"rendered":"

<\/p>\n

\n

\u30af\u30a4\u30c3\u30af\u30a2\u30f3\u30b5\u30fc \u2014 PNC-27\u3068\u306f\uff1f<\/h3>\n

PNC-27<\/strong> \u306f\u3001\u30a2\u30eb\u30d0\u30fc\u30c8\u30fb\u30a2\u30a4\u30f3\u30b7\u30e5\u30bf\u30a4\u30f3\u533b\u79d1\u5927\u5b66\uff08Bowne, Pinto, Michl, Rauschmayer, Brower\u3089\uff09\u3067\u958b\u767a\u3055\u308c\u305f\u5408\u6210\u30ad\u30e1\u30e9\u30da\u30d7\u30c1\u30c9\uff08\u7d0432\u30a2\u30df\u30ce\u9178\uff09\u3067\u3042\u308a\u30012\u3064\u306e\u6a5f\u80fd\u30c9\u30e1\u30a4\u30f3\u3092\u878d\u5408\u3057\u3066\u3044\u307e\u3059\uff1a HDM2\u7d50\u5408\u30d8\u30ea\u30c3\u30af\u30b9<\/strong> p53\u30c8\u30e9\u30f3\u30b9\u6d3b\u6027\u5316\u30c9\u30e1\u30a4\u30f3\u306e12\u201326\u6b8b\u57fa\uff08\u914d\u5217\uff1aPPLSQETFSDLWKLL\uff09\u306b\u7531\u6765\u3057\u3001\u3055\u3089\u306b \u819c\u6ede\u7559\u30da\u30d7\u30c1\u30c9\uff08MRP\uff09<\/strong> \u4ed8\u52a0\u3055\u308c\u3066\u304a\u308a\u3001\u304c\u3093\u7d30\u80de\u306e\u7d30\u80de\u819c\u3092\u56fa\u5b9a\u30fb\u7834\u58ca\u3057\u307e\u3059\u3002\u4f5c\u7528\u6a5f\u5e8f\u306e\u524d\u63d0\u306f\u3001HDM2\uff08MDM2\u306e\u30d2\u30c8\u76f8\u540c\u4f53\uff09\u304c\u7570\u5e38\u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u306e\u306f\u3001 \u7d30\u80de\u819c\u8868\u9762<\/em> \u304c\u3093\u7d30\u80de\u306e\uff08\u901a\u5e38\u306f\u6838\u5185\u3067p53\u3092\u5206\u89e3\u3059\u308b\u5834\u6240\u3067\u306f\u306a\u304f\uff09\u3067\u3059\u3002PNC-27\u306f\u8868\u9762\u306b\u9732\u51fa\u3057\u305fHDM2\u306b\u7d50\u5408\u3057\u3001MRP\u30c9\u30e1\u30a4\u30f3\u304c\u8102\u8cea\u4e8c\u91cd\u5c64\u3092\u7834\u58ca\u3057\u3066\u3001\u304c\u3093\u7d30\u80de\u304c\u6025\u901f\u306a\u819c\u6eb6\u89e3\u3068\u30cd\u30af\u30ed\u30fc\u30b7\u30b9\u7d30\u80de\u6b7b\u3092\u8d77\u3053\u3057\u307e\u3059\u3002\u81b5\u81d3\u304c\u3093\u3001\u767d\u8840\u75c5\u3001\u4e73\u304c\u3093\u3001\u305d\u306e\u4ed6\u306e\u816b\u760d\u30e2\u30c7\u30eb\u3067\u767a\u8868\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7814\u7a76\u76ee\u7684\u3067\u306e\u4f7f\u7528\u306b\u9650\u308a\u307e\u3059\u3002 \u816b\u760d\u6a19\u7684\u578b\u819c\u7834\u58ca\u30ad\u30e1\u30e9\u30da\u30d7\u30c1\u30c9\u3067\u3059\u3002<\/em><\/p>\n<\/div>\n

MedsBase\u3067\u5f97\u3089\u308c\u308b\u3082\u306e\uff1a<\/strong> \u51cd\u7d50\u4e7e\u71e5\u3001HPLC\u7d14\u5ea699%\u4ee5\u4e0a\u306ePNC-27\u30ad\u30e1\u30e9\u30da\u30d7\u30c1\u30c9 \u00b7 \u3054\u8981\u671b\u306b\u5fdc\u3058\u3066\u5206\u6790\u8a3c\u660e\u66f8\uff08COA\uff09\u63d0\u4f9b \u00b7 \u4e2d\u8eab\u304c\u308f\u304b\u3089\u306a\u3044\u6e29\u5ea6\u5b89\u5b9a\u6027\u5305\u88c5 \u00b7 \u5168\u4e16\u754c\u306e\u7814\u7a76\u7528\u4f9b\u7d66\u5b85\u914d\u4fbf \u00b7 1,400\u4ef6\u4ee5\u4e0a\u306e\u78ba\u8a8d\u6e08\u307f\u30ec\u30d3\u30e5\u30fc \u30ab\u30b9\u30bf\u30de\u30fc\u30ec\u30d3\u30e5\u30fc<\/a><\/div>\n

\ud83d\udce6 \u3059\u3079\u3066\u306e\u3054\u6ce8\u6587\u306f\u3001\u5f53\u5e97\u306e \u518d\u767a\u9001\u4fdd\u8a3c\u30dd\u30ea\u30b7\u30fc<\/strong><\/a> \u2014 \u4e07\u304c\u4e00\u300120\u55b6\u696d\u65e5\u4ee5\u5185\u306b\u5546\u54c1\u304c\u5c4a\u304b\u306a\u3044\u5834\u5408\u306f\u3001\u518d\u767a\u9001\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u4ed5\u69d8<\/th>\n\u8a73\u7d30<\/th>\n<\/tr>\n<\/thead>\n
\u5316\u5408\u7269\u30af\u30e9\u30b9<\/strong><\/td>\n\u5408\u6210\u7d0432\u30a2\u30df\u30ce\u9178\u30ad\u30e1\u30e9\u30da\u30d7\u30c1\u30c9\uff1b\u816b\u760d\u6a19\u7684\u578b\u819c\u7834\u58ca\u6cbb\u7642\u30da\u30d7\u30c1\u30c9\uff1bHDM2\u7d50\u5408\u30d8\u30ea\u30c3\u30af\u30b9\uff0b\u819c\u6ede\u7559\u30da\u30d7\u30c1\u30c9\uff08MRP\uff09\u30ad\u30e1\u30e9<\/td>\n<\/tr>\n
\u5316\u5b66\u540d<\/strong><\/td>\nPNC-27\uff08\u30da\u30d7\u30c1\u30c9\u6838\u69cb\u7bc9\u726927\uff1b\u5225\u540d\uff1ap53-MRP\u30ad\u30e1\u30e9\u3001p53(12-26)-MRP\u69cb\u7bc9\u7269\uff09<\/td>\n<\/tr>\n
CAS\u756a\u53f7<\/strong><\/td>\n\u7814\u7a76\u7528\u30b0\u30ec\u30fc\u30c9\u306e\u30ad\u30e1\u30e9\u30da\u30d7\u30c1\u30c9 \u2014 \u6a19\u6e96\u7684\u306aCAS\u756a\u53f7\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u516c\u8868\u3055\u308c\u305f\u914d\u5217\u3068\u4f9b\u7d66\u5143\u306eCOA\u306b\u3088\u308a\u8b58\u5225\u3055\u308c\u307e\u3059\u3002<\/td>\n<\/tr>\n
\u914d\u5217<\/strong><\/td>\nN\u672b\u7aefHDM2\u7d50\u5408\u30d8\u30ea\u30c3\u30af\u30b9\uff08p53\u8ee2\u5199\u6d3b\u6027\u5316\u6b8b\u57fa12\u201326\uff09\uff1a PPLSQETFSDLWKLL<\/strong>; \uff1b\u30ea\u30f3\u30ab\u30fc\uff1bC\u672b\u7aef\u819c\u6ede\u7559\u30da\u30d7\u30c1\u30c9\uff08MRP\u3001\u914d\u5217\u306f\u767a\u8868\u6587\u732e\u306b\u3088\u308a\u82e5\u5e72\u7570\u306a\u308a\u307e\u3059 \u2014 \u6b63\u78ba\u306a\u30ed\u30c3\u30c8\u914d\u5217\u306b\u3064\u3044\u3066\u306fCOA\u3092\u53c2\u7167\u3057\u3066\u304f\u3060\u3055\u3044\uff09\u3002\u5168\u7d0432\u30a2\u30df\u30ce\u9178\u3002<\/td>\n<\/tr>\n
\u5206\u5b50\u91cf<\/strong><\/td>\n\u7d043,800 Da\uff08\u6b63\u78ba\u306aMRP\u914d\u5217\u306b\u3088\u308b\uff09<\/td>\n<\/tr>\n
\u5206\u5b50\u5f0f<\/strong><\/td>\n\u7d0432\u6b8b\u57fa\u30ad\u30e1\u30e9\u30da\u30d7\u30c1\u30c9 \u2014 \u914d\u5217\u7531\u6765\u306e\u6982\u7b97\u5206\u5b50\u5f0f C173<\/sub>H278<\/sub>N52<\/sub>O43<\/sub>S\uff1b\u767a\u8868\u5206\u5b50\u91cf\u7d043,800 Da\uff08\u6b63\u78ba\u306a\u819c\u6ede\u7559\u30da\u30d7\u30c1\u30c9\u30ea\u30f3\u30ab\u30fc\u306b\u3088\u308b\uff1b\u30ed\u30c3\u30c8COA\u3092\u53c2\u7167\uff09\u3002<\/td>\n<\/tr>\n
\u4f5c\u7528\u6a5f\u5e8f<\/strong><\/td>\n\u816b\u760d\u7d30\u80de\u9078\u629e\u7684\u819c\u6eb6\u89e3<\/strong>. \u3002\uff081\uff09PNC-27\u306f HDM2<\/strong> \u306b\u764c\u7d30\u80de\u306e\u7d30\u80de\u819c\u4e0a\u3067\u7d50\u5408\u3057\u307e\u3059\u3002\u6b63\u5e38\u7d30\u80de\u306fHDM2\u3092\u6838\u5185\u3067\u306e\u307f\u767a\u73fe\u3057\uff08\u305d\u3053\u3067p53\u3092\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u3057\u5206\u89e3\u3057\u3066p53\u30ec\u30d9\u30eb\u3092\u5236\u5fa1\u3057\u307e\u3059\uff09\uff1b\u764c\u7d30\u80de\u306fHDM2\u3092\u7d30\u80de\u8868\u9762\u306b\u7570\u5e38\u767a\u73fe\u3057\u307e\u3059 \u2014 \u3053\u308c\u306f\u816b\u760d\u7279\u7570\u7684\u30de\u30fc\u30ab\u30fc\u3067\u3059\u3002\uff082\uff09\u7d50\u5408\u5f8c\u3001\u819c\u6ede\u7559\u30da\u30d7\u30c1\u30c9\uff08MRP\uff09\u30c9\u30e1\u30a4\u30f3\u304c\u8102\u8cea\u4e8c\u91cd\u5c64\u306b\u633f\u5165\u3055\u308c\u307e\u3059\u3002\uff083\uff09\u7d50\u5408\u3057\u305fPNC-27\u5206\u5b50\u306e\u591a\u91cf\u4f53\u5316\u306b\u3088\u308a\u819c\u5b54\u304c\u5f62\u6210\u3055\u308c\u308b \u2192 \u6570\u5206\u304b\u3089\u6570\u6642\u9593\u4ee5\u5185\u306b\u6025\u901f\u306a\u58ca\u6b7b\u6027\u7d30\u80de\u6b7b\u304c\u8d77\u3053\u308a\u307e\u3059\u3002\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u58ca\u6b7b\u6027\u819c\u6eb6\u89e3\uff08\u53e4\u5178\u7684\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3067\u306f\u3042\u308a\u307e\u305b\u3093\uff09\u3067\u3042\u308a\u3001PNC-27\u306f\u30ab\u30b9\u30d1\u30fc\u30bc\u7d4c\u8def\u3092\u4ecb\u3059\u308b\u6297\u764c\u30da\u30d7\u30c1\u30c9\u3068\u306f\u533a\u5225\u3055\u308c\u307e\u3059\u3002<\/td>\n<\/tr>\n
\u816b\u760d\u7d30\u80de\u9078\u629e\u6027<\/strong><\/td>\n\u767a\u8868\u3055\u308c\u305f\u7814\u7a76\u3067\u306f\u3001\u81b5\u81d3\u817a\u764c\u3001AML\u304a\u3088\u3073ALL\u767d\u8840\u75c5\u3001\u4e73\u764c\u3001\u524d\u7acb\u817a\u764c\u3001\u9ed2\u8272\u816b\u3001\u305d\u306e\u4ed6\u306e\u816b\u760d\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u9078\u629e\u7684\u306a\u764c\u7d30\u80de\u6bba\u50b7\u304c\u5b9f\u8a3c\u3055\u308c\u3066\u304a\u308a\u3001\u8868\u9762HDM2\u767a\u73fe\u3092\u6b20\u304f\u5bfe\u5fdc\u3059\u308b\u6b63\u5e38\u7d30\u80de\u5bfe\u7167\u306f\u5f71\u97ff\u3092\u53d7\u3051\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/td>\n<\/tr>\n
\u5f62\u614b<\/strong><\/td>\n\u51cd\u7d50\u4e7e\u71e5\u3055\u308c\u305f\u767d\u8272\uff5e\u5fae\u9ec4\u767d\u8272\u306e\u7c89\u672b\uff1b\u7814\u7a76\u7528\u306e\u5358\u56de\u4f7f\u7528\u30d0\u30a4\u30a2\u30eb<\/td>\n<\/tr>\n
\u7d14\u5ea6<\/strong><\/td>\n\u226599%\uff08HPLC\u691c\u8a3c\u6e08\u307f\u3001COA\u306f\u3054\u8981\u671b\u306b\u5fdc\u3058\u3066\u63d0\u4f9b\uff09\uff1bMALDI-TOF\u8cea\u91cf\u5206\u6790\u6cd5\u306b\u3088\u308a\u30ad\u30e1\u30e9\u7279\u7570\u7684\u5206\u5b50\u91cf\u3067\u78ba\u8a8d\u6e08\u307f\u3002<\/td>\n<\/tr>\n
\u4fdd\u7ba1\u65b9\u6cd5<\/strong><\/td>\n\u51cd\u7d50\u4e7e\u71e5\u54c1\uff1a2\u301c8\u00b0C\u3067\u77ed\u671f\u4fdd\u5b58\u3001\u221220\u00b0C\u3067\u9577\u671f\u4fdd\u5b58\u3002\u518d\u6eb6\u89e3\u5f8c\uff1a2\u301c8\u00b0C\u300130\u65e5\u4ee5\u5185\u306b\u4f7f\u7528\u3002\u7e70\u308a\u8fd4\u3057\u306e\u51cd\u7d50\u878d\u89e3\u306f\u907f\u3051\u3066\u304f\u3060\u3055\u3044\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u7528\u9014<\/strong><\/td>\n\u5b9f\u9a13\u5ba4\u7814\u7a76\u7528\u306e\u307f\u3002\u4eba\u307e\u305f\u306f\u52d5\u7269\u306e\u8a3a\u65ad\u30fb\u6cbb\u7642\u76ee\u7684\u3067\u306e\u4f7f\u7528\u306f\u3067\u304d\u307e\u305b\u3093\u3002PNC-27\u306f\u6b63\u5f0f\u306a\u81e8\u5e8a\u958b\u767a\u6bb5\u968e\u306b\u5165\u3063\u3066\u3044\u306a\u3044\u524d\u81e8\u5e8a\u7814\u7a76\u30c4\u30fc\u30eb\u3067\u3059\u3002WADA\u7981\u6b62\u30ea\u30b9\u30c8\u306b\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/p>\n

\u4f5c\u7528\u6a5f\u5e8f \u2014 HDM2\u3092\u6a19\u7684\u3068\u3059\u308b\u819c\u6eb6\u89e3<\/h2>\n

PNC-27\u306f\u3001\u30a2\u30eb\u30d0\u30fc\u30c8\u30fb\u30a2\u30a4\u30f3\u30b7\u30e5\u30bf\u30a4\u30f3\u533b\u79d1\u5927\u5b66\u306eBowne \/ Pinto \/ Michl \/ Rauschmayer\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u304c\u3001\u4e00\u4f8b\u3068\u3057\u3066\u958b\u767a\u3057\u305f \u30ad\u30e1\u30e9\u30da\u30d7\u30c1\u30c9\u85ac\u5264\u8a2d\u8a08<\/strong> \u816b\u760d\u5b66\u306b\u5fdc\u7528\u3055\u308c\u3066\u304a\u308a\u3001\u816b\u760d\u6a19\u7684\u30c9\u30e1\u30a4\u30f3\uff08p53\u7531\u6765HDM2\u7d50\u5408\u30d8\u30ea\u30c3\u30af\u30b9\uff09\u3068\u6c4e\u7528\u30ad\u30e9\u30fc\u30c9\u30e1\u30a4\u30f3\uff08\u819c\u6ede\u7559\u30da\u30d7\u30c1\u30c9\uff09\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u3044\u307e\u3059\u3002\u8a2d\u8a08\u306e\u30ed\u30b8\u30c3\u30af\uff1a<\/p>\n