{"id":71489,"date":"2026-05-20T10:10:00","date_gmt":"2026-05-20T10:10:00","guid":{"rendered":"https:\/\/medsbase.com\/slu-pp-332\/"},"modified":"2026-05-21T07:14:09","modified_gmt":"2026-05-21T07:14:09","slug":"slu-pp-332","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ja\/product\/slu-pp-332\/","title":{"rendered":"SLU-PP-332\uff08\u6c4eERR\u30a2\u30b4\u30cb\u30b9\u30c8\u904b\u52d5\u6a21\u5023\u85ac\uff09"},"content":{"rendered":"

<\/p>\n

\n

\u30af\u30a4\u30c3\u30af\u30a2\u30f3\u30b5\u30fc \u2014 SLU-PP-332\u3068\u306f\uff1f<\/h3>\n

SLU-PP-332<\/strong> \uff08CAS 303760-60-3\u3001\u5206\u5b50\u5f0f C18<\/sub>H14<\/sub>N2<\/sub>O2<\/sub>, \u3001\u5206\u5b50\u91cf 290.3 g\/mol\uff09\u306f\u5408\u6210\u4f4e\u5206\u5b50\u5316\u5408\u7269 \u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u95a2\u9023\u53d7\u5bb9\u4f53\u306e\u30d1\u30f3\u30a2\u30b4\u30cb\u30b9\u30c8<\/strong> \uff08ERR\u03b1 \/ ERR\u03b2 \/ ERR\u03b3\uff09\u306f\u3001\u30bb\u30f3\u30c8\u30eb\u30a4\u30b9\u5927\u5b66\u306eBurris\u7814\u7a76\u5ba4\u3067\u958b\u767a\u3055\u308c\u307e\u3057\u305f\u3002ERR\u306f\u30aa\u30fc\u30d5\u30a1\u30f3\u6838\u5185\u53d7\u5bb9\u4f53\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308a\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u65b0\u751f\u3001\u8102\u80aa\u9178\u9178\u5316\u3001\u9178\u5316\u578b\u7b4b\u7dda\u7dad\u306e\u767a\u9054\u3001\u304a\u3088\u3073\u904b\u52d5\u306b\u3088\u3063\u3066\u901a\u5e38\u6d3b\u6027\u5316\u3055\u308c\u308b\u7b4b\u9069\u5fdc\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u4fc3\u9032\u3057\u307e\u3059 \u2014 \u3053\u308c\u306b\u3088\u308aSLU-PP-332\u306f\u4e3b\u8981\u306a \u201c\u300c\u904b\u52d5\u6a21\u5023\u85ac\u300d\u201d<\/strong> \u7814\u7a76\u30c4\u30fc\u30eb\u3002Billon\u3089\uff082023\u5e74\u3001, ACS Chemical Biology<\/em>\uff09 \u2014 \u5358\u56de\u6295\u4e0e\u306b\u3088\u308a\u9aa8\u683c\u7b4b\u306b\u6709\u9178\u7d20\u904b\u52d5\u5fdc\u7b54\u907a\u4f1d\u5b50\u30b7\u30b0\u30cd\u30c1\u30e3\u30fc\u304c\u8a98\u5c0e\u3055\u308c\u3001\u6162\u6027\u6295\u4e0e\u3067\u306f\u30de\u30a6\u30b9\u306eIIa\u578b\u9178\u5316\u578b\u7b4b\u7dda\u7dad\u306e\u5272\u5408\u304c\u5897\u52a0\u3057\u3001\u6301\u4e45\u529b\u304c\u5411\u4e0a\u3057\u307e\u3059\u3002 \u4f4e\u5206\u5b50\u5316\u5408\u7269 \u2014 \u30da\u30d7\u30c1\u30c9\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/em> \u3054\u6ce8\u610f\uff1a\u4e00\u90e8\u306e\u4f9b\u7d66\u5143\u306e\u30d0\u30c3\u30c1\u3067\u306fSLU-PP-322 \/ SLU-PP-332\u304c\u4e92\u63db\u7684\u306b\u8868\u793a\u3055\u308c\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u3044\u305a\u308c\u3082\u540c\u3058Burris\u7814\u7a76\u5ba4\u306eERR\u30d1\u30f3\u30a2\u30b4\u30cb\u30b9\u30c8\u3092\u6307\u3057\u307e\u3059\u3002\u30d0\u30c3\u30c1\u56fa\u6709\u306e\u8b58\u5225\u60c5\u5831\u306b\u3064\u3044\u3066\u306fCOA\u3092\u3054\u78ba\u8a8d\u304f\u3060\u3055\u3044\u3002\u7814\u7a76\u7528\u8a66\u85ac\u306e\u307f\u3002<\/p>\n<\/div>\n

MedsBase\u3067\u5f97\u3089\u308c\u308b\u3082\u306e\uff1a<\/strong> \u51cd\u7d50\u4e7e\u71e5\u54c1 \u226599% HPLC\u691c\u8a3c\u6e08\u307f SLU-PP-332 \u00b7 COA\u306f\u3054\u8981\u671b\u306b\u5fdc\u3058\u3066\u63d0\u4f9b\u53ef\u80fd \u00b7 \u6e29\u5ea6\u5b89\u5b9a\u6027\u306e\u3042\u308b\u4e2d\u8eab\u304c\u308f\u304b\u3089\u306a\u3044\u68b1\u5305 \u00b7 \u5168\u4e16\u754c\u7814\u7a76\u7528\u4f9b\u7d66\u30af\u30fc\u30ea\u30a8 \u00b7 1,400\u4ef6\u4ee5\u4e0a\u306e\u691c\u8a3c\u6e08\u307f \u30ab\u30b9\u30bf\u30de\u30fc\u30ec\u30d3\u30e5\u30fc<\/a><\/div>\n

\ud83d\udce6 \u3059\u3079\u3066\u306e\u3054\u6ce8\u6587\u306f\u3001\u5f53\u5e97\u306e \u518d\u767a\u9001\u4fdd\u8a3c\u30dd\u30ea\u30b7\u30fc<\/strong><\/a> \u2014 \u4e07\u304c\u4e00\u300120\u55b6\u696d\u65e5\u4ee5\u5185\u306b\u5546\u54c1\u304c\u5c4a\u304b\u306a\u3044\u5834\u5408\u306f\u3001\u518d\u767a\u9001\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u4ed5\u69d8<\/th>\n\u8a73\u7d30<\/th>\n<\/tr>\n<\/thead>\n
\u5316\u5408\u7269\u30af\u30e9\u30b9<\/strong><\/td>\n\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u95a2\u9023\u53d7\u5bb9\u4f53\uff08ERR\u03b1 \/ ERR\u03b2 \/ ERR\u03b3\uff09\u306e\u5408\u6210\u4f4e\u5206\u5b50\u30d1\u30f3\u30a2\u30b4\u30cb\u30b9\u30c8\uff1b\u30aa\u30fc\u30d5\u30a1\u30f3\u6838\u5185\u53d7\u5bb9\u4f53\u30a2\u30b4\u30cb\u30b9\u30c8\uff1b\u904b\u52d5\u6a21\u5023\u7814\u7a76\u30c4\u30fc\u30eb\uff1b; \u30da\u30d7\u30c1\u30c9\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/em><\/td>\n<\/tr>\n
\u5316\u5b66\u540d<\/strong><\/td>\nSLU-PP-332\uff08\u5225\u540d\uff1a\u4e00\u90e8\u306e\u30d0\u30c3\u30c1\u3067\u306fSLU-PP-322\uff1b\u30d1\u30f3ERR\u30a2\u30b4\u30cb\u30b9\u30c8\uff1bBurris\u7814\u7a76\u5ba4\u5316\u5408\u7269332\uff09<\/td>\n<\/tr>\n
CAS\u756a\u53f7<\/strong><\/td>\n303760-60-3\uff08\u6a19\u6e96CAS\u756a\u53f7\u3001MedKoo \/ MedChemExpress \/ \u79d1\u5b66\u6587\u732e\u306b\u57fa\u3065\u304f\uff09<\/td>\n<\/tr>\n
\u5206\u5b50\u5f0f<\/strong><\/td>\nC18<\/sub>H14<\/sub>N2<\/sub>O2<\/sub><\/td>\n<\/tr>\n
\u5206\u5b50\u91cf<\/strong><\/td>\n290.32 g\/mol<\/td>\n<\/tr>\n
\u4f5c\u7528\u6a5f\u5e8f<\/strong><\/td>\n\u30d1\u30f3\u30a2\u30b4\u30cb\u30b9\u30c8\uff1a ERR\u03b1, ERR\u03b2, ERR\u03b3<\/strong> \u6838\u5185\u53d7\u5bb9\u4f53\u3067\u3042\u308a\u3001ERR\u03b1\u306b\u5bfe\u3059\u308b\u9078\u629e\u6027\u306fERR\u03b3\u306e\u7d044\u500d\u3002EC50<\/sub> ERR\u03b1\u7d0498 nM\uff08Billon et al. 2023\uff09\u3002ERR\u53d7\u5bb9\u4f53\u306e\u6d3b\u6027\u5316\u306f\u3001PGC-1\u03b1\u6a19\u7684\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u5177\u4f53\u7684\u306b\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u65b0\u751f\uff08TFAM\u3001NRF1\u3001NRF2\uff09\u3001\u8102\u80aa\u9178\u03b2\u9178\u5316\uff08CPT1B\u3001MCAD\u3001LCAD\uff09\u3001\u9178\u5316\u7684\u30ea\u30f3\u9178\u5316\u8907\u5408\u4f53\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u3001\u9178\u5316\u578b\u7b4b\u7dda\u7dad\u30bf\u30a4\u30d7\u306e\u30df\u30aa\u30b7\u30f3\u91cd\u9396\u304c\u542b\u307e\u308c\u307e\u3059\u3002\u6700\u7d42\u7684\u306a\u52b9\u679c\u306f\u3001\u904b\u52d5\u9069\u5fdc\u306e\u8ee2\u5199\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u6a21\u5023\u3057\u307e\u3059\u3002<\/td>\n<\/tr>\n
\u914d\u5217<\/strong><\/td>\n\u8a72\u5f53\u306a\u3057\uff08\u4f4e\u5206\u5b50\u5408\u6210\u5316\u5408\u7269 \u2014 \u30da\u30d7\u30c1\u30c9\u3067\u306f\u3042\u308a\u307e\u305b\u3093\uff09<\/td>\n<\/tr>\n
\u5f62\u614b<\/strong><\/td>\n\u51cd\u7d50\u4e7e\u71e5\u3055\u308c\u305f\u767d\u8272\uff5e\u5fae\u9ec4\u767d\u8272\u306e\u7c89\u672b\uff1b\u7814\u7a76\u7528\u306e\u5358\u56de\u4f7f\u7528\u30d0\u30a4\u30a2\u30eb<\/td>\n<\/tr>\n
\u7d14\u5ea6<\/strong><\/td>\n\u226599%\uff08HPLC\u691c\u8a3c\u6e08\u307f\u3001COA\u306f\u3054\u8981\u671b\u306b\u5fdc\u3058\u3066\u63d0\u4f9b\uff09<\/td>\n<\/tr>\n
\u6eb6\u89e3\u6027<\/strong><\/td>\nDMSO\u306b50 mg\/mL\u4ee5\u4e0a\u6eb6\u89e3\uff1b\u6c34\u6eb6\u6027\u306f\u4e2d\u7a0b\u5ea6\uff08\u30b5\u30d6mg\/mL\uff09\u3002in vitro\u5b9f\u9a13\u3067\u306f\u3001DMSO\u30b9\u30c8\u30c3\u30af\u6eb6\u6db2\u3092\u8abf\u88fd\u3057\u3001\u4f7f\u7528\u76f4\u524d\u306b\u57f9\u990a\u6db2\u3067\u5e0c\u91c8\u3057\u307e\u3059\u3002in vivo\u5b9f\u9a13\u3067\u306f\u3001\u901a\u5e38DMSO\/PEG\/\u751f\u7406\u98df\u5869\u6c34\u307e\u305f\u306f\u985e\u4f3c\u306e\u5171\u6eb6\u5a92\u7cfb\u3092\u4f7f\u7528\u3057\u307e\u3059\u3002<\/td>\n<\/tr>\n
\u4fdd\u7ba1\u65b9\u6cd5<\/strong><\/td>\n\u51cd\u7d50\u4e7e\u71e5\u54c1\uff1a\u77ed\u671f\u9593\u306f2\uff5e8\u00b0C\u3001\u9577\u671f\u9593\uff0836\u304b\u6708\u4ee5\u4e0a\uff09\u306f\u221220\u00b0C\u3002DMSO\u6eb6\u89e3\u5f8c\uff1a\u221220\u00b0C\u3067\u4fdd\u5b58\u3057\u3001\u4e00\u5ea6\u306e\u89e3\u51cd\u3067\u4f7f\u7528\u3002\u5149\u304b\u3089\u4fdd\u8b77\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u7e70\u308a\u8fd4\u3057\u306e\u51cd\u7d50\u878d\u89e3\u306f\u907f\u3051\u3066\u304f\u3060\u3055\u3044\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u7528\u9014<\/strong><\/td>\n\u7814\u7a76\u7528\u8a66\u85ac\u3067\u3042\u308a\u3001\u30d2\u30c8\u307e\u305f\u306f\u52d5\u7269\u306e\u8a3a\u65ad\u30fb\u6cbb\u7642\u76ee\u7684\u306b\u306f\u4f7f\u7528\u3067\u304d\u307e\u305b\u3093\u3002\u73fe\u6642\u70b9\u3067\u306fWADA\u7981\u6b62\u30ea\u30b9\u30c8\u306b\u7279\u5b9a\u540d\u79f0\u3068\u3057\u3066\u306f\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u3088\u308a\u5e83\u7bc4\u306aS4\uff08\u30db\u30eb\u30e2\u30f3\u304a\u3088\u3073\u4ee3\u8b1d\u8abf\u7bc0\u85ac\uff09\u30af\u30e9\u30b9\u306b\u306f\u904b\u52d5\u6a21\u5023\u5316\u5408\u7269\u304c\u542b\u307e\u308c\u3066\u304a\u308a\u3001SLU-PP-332\u306e\u898f\u5236\u72b6\u6cc1\u306f\u5909\u5316\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u306b\u7814\u7a76\u8005\u306f\u7559\u610f\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/p>\n

\u4f5c\u7528\u6a5f\u5e8f \u2014 Pan-ERR\u4f5c\u52d5\u85ac\u304c\u904b\u52d5\u9069\u5fdc\u8ee2\u5199\u3092\u99c6\u52d5\u3059\u308b<\/h2>\n

SLU-PP-332\u306f\u3001\u767a\u8868\u6587\u732e\u306b\u304a\u3044\u3066\u6700\u3082\u5f15\u7528\u3055\u308c\u3066\u3044\u308b\u5408\u6210\u4f4e\u5206\u5b50ERR\u30d1\u30f3\u30a2\u30b4\u30cb\u30b9\u30c8\u3067\u3059\u3002ERR\uff08\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u95a2\u9023\u53d7\u5bb9\u4f53\u03b1\u3001\u03b2\u3001\u03b3\uff09\u306f\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\u306eDNA\u7d50\u5408\u30c9\u30e1\u30a4\u30f3\u3092\u5171\u6709\u3057\u306a\u304c\u3089\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306b\u306f\u7d50\u5408\u3057\u306a\u3044\u30aa\u30fc\u30d5\u30a1\u30f3\u6838\u5185\u53d7\u5bb9\u4f53\u3067\u3042\u308a\u3001\u5929\u7136\u306e\u5185\u5728\u6027\u30ea\u30ac\u30f3\u30c9\u304c\u306a\u304f\u3066\u3082\u69cb\u6210\u7684\u306b\u6d3b\u6027\u3092\u793a\u3057\u3001\u4ee3\u308f\u308a\u306b\u30b3\u30a2\u30af\u30c1\u30d9\u30fc\u30bf\u30fc\u306e\u7d50\u5408\uff08\u6700\u3082\u91cd\u8981\u306a\u306e\u306fPGC-1\u03b1\uff09\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u307e\u3059\u3002ERR\u306f\u4ee5\u4e0b\u306e\u4e3b\u8981\u306a\u8ee2\u5199\u30c9\u30e9\u30a4\u30d0\u30fc\u3067\u3059\uff1a<\/p>\n