{"id":71510,"date":"2026-05-20T10:35:00","date_gmt":"2026-05-20T10:35:00","guid":{"rendered":"https:\/\/medsbase.com\/b7-33\/"},"modified":"2026-05-21T07:14:08","modified_gmt":"2026-05-21T07:14:08","slug":"b7-33","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ja\/product\/b7-33\/","title":{"rendered":"B7-33\uff08\u30d0\u30a4\u30a2\u30b9\u578bRXFP1\u30ea\u30e9\u30ad\u30b7\u30f3B\u9396\u30a2\u30ca\u30ed\u30b0\uff09"},"content":{"rendered":"

<\/p>\n

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\u30af\u30a4\u30c3\u30af\u30a2\u30f3\u30b5\u30fc \u2014 B7-33\u3068\u306f\u4f55\u3067\u3059\u304b\uff1f<\/h3>\n

B7-33<\/strong> \u306f\u5408\u621033\u30a2\u30df\u30ce\u9178\u306e \u5358\u9396\u30ea\u30e9\u30af\u30b7\u30f3B\u9396\u30da\u30d7\u30c1\u30c9\u30a2\u30ca\u30ed\u30b0<\/strong> Hossain\u3001Howe\u3068\u30d5\u30ed\u30fc\u30ea\u30fc\u7814\u7a76\u6240\uff08\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\u30fb\u30e1\u30eb\u30dc\u30eb\u30f3\uff09\u306e\u540c\u50da\u3089\u306b\u3088\u308a\u958b\u767a\u3055\u308c\u3001\u306b\u767a\u8868\u3055\u308c\u307e\u3057\u305f\u3002 Nature Communications<\/em> (2017)\u3002\u5929\u7136\u306e\u30ea\u30e9\u30af\u30b7\u30f3-2\uff08\u6a19\u6e96\u7684\u306a\u7dda\u7dad\u75c7\u6cbb\u7642\u30db\u30eb\u30e2\u30f3\u3067\u3001\u81e8\u5e8a\u7684\u306b\u306fSerelaxin\uff09\u306f\u3001\u30b8\u30b9\u30eb\u30d5\u30a3\u30c9\u7d50\u5408\u3057\u305fA\/B\u9396\u304b\u3089\u306a\u308b2\u672c\u9396\u30da\u30d7\u30c1\u30c9\u3067\u3001RXFP1\uff08\u6297\u7dda\u7dad\u5316\uff09\u304a\u3088\u3073RXFP2\uff08\u764c\u7d30\u80de\u751f\u5b58\u4fc3\u9032\uff09\u306e\u4e21\u53d7\u5bb9\u4f53\u3092\u6d3b\u6027\u5316\u3057\u307e\u3059\u304c\u3001B7-33\u306f RXFP1\u30d0\u30a4\u30a2\u30b9\u30a2\u30b4\u30cb\u30b9\u30c8<\/strong> \u2014 \u5358\u9396B\u9396\u306e\u307f\u306e\u8a2d\u8a08\u3067\u3001RXFP1\u306e\u6297\u7dda\u7dad\u5316\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\uff08ERK1\/2\u7d4c\u8def \u2192 MMP-2\u4e0a\u65b9\u5236\u5fa1 \u2192 ECM\u5206\u89e3\uff09\u3092\u9078\u629e\u7684\u306b\u6d3b\u6027\u5316\u3057\u3001Serelaxin\u306e\u958b\u767a\u4e2d\u6b62\u306e\u4e00\u56e0\u3068\u306a\u3063\u305fRXFP1\u306e\u767a\u304c\u3093\u4fc3\u9032\u6027cAMP\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u56de\u907f\u3057\u307e\u3059\u3002\u516c\u8868\u3055\u308c\u3066\u3044\u308b\u7814\u7a76\u5fdc\u7528\uff1a\u5fc3\u4e0d\u5168\u3001\u809d\u81d3\uff0f\u814e\u81d3\uff0f\u80ba\uff0f\u5fc3\u81d3\u306e\u7dda\u7dad\u75c7\u3001\u5b50\u7647\u524d\u75c7\u3002 \u7814\u7a76\u7528\u306b\u9650\u308a\u307e\u3059\u3002<\/em><\/p>\n<\/div>\n

MedsBase\u3067\u5f97\u3089\u308c\u308b\u3082\u306e\uff1a<\/strong> \u51cd\u7d50\u4e7e\u71e5 \u00b7 HPLC\u691c\u8a3c\u6e08\u307f\u7d14\u5ea699%\u4ee5\u4e0a\u306eB7-33 \u00b7 \u5206\u6790\u8a3c\u660e\u66f8\uff08COA\uff09\u306f\u3054\u8981\u671b\u306b\u5fdc\u3058\u3066\u63d0\u4f9b \u00b7 \u4e2d\u8eab\u304c\u308f\u304b\u3089\u306a\u3044\u6e29\u5ea6\u5b89\u5b9a\u68b1\u5305 \u00b7 \u5168\u4e16\u754c\u306e\u7814\u7a76\u7528\u914d\u9001\u696d\u8005 \u00b7 1,400\u4ef6\u4ee5\u4e0a\u306e\u691c\u8a3c\u6e08\u307f \u30ab\u30b9\u30bf\u30de\u30fc\u30ec\u30d3\u30e5\u30fc<\/a><\/div>\n

\ud83d\udce6 \u3059\u3079\u3066\u306e\u3054\u6ce8\u6587\u306f\u3001\u5f53\u5e97\u306e \u518d\u767a\u9001\u4fdd\u8a3c\u30dd\u30ea\u30b7\u30fc<\/strong><\/a> \u2014 \u4e07\u304c\u4e00\u300120\u55b6\u696d\u65e5\u4ee5\u5185\u306b\u5546\u54c1\u304c\u5c4a\u304b\u306a\u3044\u5834\u5408\u306f\u3001\u518d\u767a\u9001\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
\u4ed5\u69d8<\/th>\n\u8a73\u7d30<\/th>\n<\/tr>\n<\/thead>\n
\u5316\u5408\u7269\u30af\u30e9\u30b9<\/strong><\/td>\n\u5408\u621033\u30a2\u30df\u30ce\u9178\u5358\u9396\u30ea\u30e9\u30ad\u30b7\u30f3B\u9396\u30a2\u30ca\u30ed\u30b0\uff1b\u30d0\u30a4\u30a2\u30b9\u578bRXFP1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\uff08\u6297\u7dda\u7dad\u5316ERK\u7d4c\u8def\u3001cAMP\u4f9d\u5b58\u6027\u306e\u7d30\u80de\u751f\u5b58\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u4f4e\u6e1b\uff09<\/td>\n<\/tr>\n
\u5316\u5b66\u540d<\/strong><\/td>\nB7-33\uff08\u5b89\u5b9a\u5316\u4fee\u98fe\u3092\u65bd\u3057\u305f\u30ea\u30e9\u30ad\u30b7\u30f3B\u93967-33\u30a2\u30ca\u30ed\u30b0\uff1bHossain et al. 2017 Nat Commun\uff09<\/td>\n<\/tr>\n
CAS\u756a\u53f7<\/strong><\/td>\n\u7814\u7a76\u7528\u30da\u30d7\u30c1\u30c9 \u2014 \u5e83\u304f\u767b\u9332\u3055\u308c\u305f\u5358\u4e00\u306eCAS\u756a\u53f7\u306f\u3042\u308a\u307e\u305b\u3093\uff1b\u8b58\u5225\u306f\u516c\u8868\u914d\u5217\u3068\u4f9b\u7d66\u5143\u306e\u5206\u6790\u8a3c\u660e\u66f8\uff08COA\uff09\u306b\u3088\u308a\u307e\u3059<\/td>\n<\/tr>\n
\u5206\u5b50\u5f0f<\/strong><\/td>\n\u5358\u939633\u6b8b\u57faB\u9396\u30a2\u30ca\u30ed\u30b0 \u2014 \u914d\u5217\u7531\u6765\u306e\u63a8\u5b9a\u5206\u5b50\u5f0f C164<\/sub>H252<\/sub>N50<\/sub>O45<\/sub>S2<\/sub>; \uff1b\u516c\u8868\u5206\u5b50\u91cf \u7d043,728 Da\uff08Hossain & Bathgate 2015, J Med Chem\uff09\u3002<\/td>\n<\/tr>\n
\u914d\u5217\u9577\uff0f\u5206\u5b50\u91cf<\/strong><\/td>\nH2-\u30ea\u30e9\u30ad\u30b7\u30f3B\u9396\u7531\u6765\u306e33\u30a2\u30df\u30ce\u9178\u3067\u3001\u6eb6\u89e3\u6027\uff0f\u5b89\u5b9a\u6027\u306e\u305f\u3081\u306bN\u672b\u7aef\u304a\u3088\u3073C\u672b\u7aef\u4fee\u98fe\u304c\u65bd\u3055\u308c\u3066\u3044\u307e\u3059\uff1b\u5206\u5b50\u91cf \u7d043,800 Da<\/td>\n<\/tr>\n
\u4f5c\u7528\u6a5f\u5e8f<\/strong><\/td>\n\u30d0\u30a4\u30a2\u30b9\u578bRXFP1\u4f5c\u52d5\u85ac<\/strong>. \u3002ERK1\/2\u3092\u9078\u629e\u7684\u306b\u6d3b\u6027\u5316 \u2192 MMP-2\uff0fMMP-9\u306e\u4e0a\u65b9\u5236\u5fa1 \u2192 \u30b3\u30e9\u30fc\u30b2\u30f3\u5206\u89e3\uff0f\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u518d\u69cb\u7bc9\u7d4c\u8def\uff08RXFP1\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u6297\u7dda\u7dad\u5316\u4f5c\u7528\uff09\u3092\u793a\u3057\u3001\u4e00\u65b9\u3067cAMP\u3092\u4ecb\u3057\u305fRXFP1\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\uff08Serelaxin\u306e\u5fc3\u81d3\u6709\u5bb3\u4e8b\u8c61\u30b7\u30b0\u30ca\u30eb\u3084\u3001\u30ea\u30e9\u30ad\u30b7\u30f3\u306e\u81e8\u5e8a\u958b\u767a\u3092\u8907\u96d1\u306b\u3057\u305f\u304c\u3093\u7d30\u80de\u751f\u5b58\u4fc3\u9032\u52b9\u679c\u306b\u95a2\u4e0e\u3059\u308b\u7d4c\u8def\uff09\u3078\u306e\u95a2\u4e0e\u306f\u4f4e\u6e1b\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/td>\n<\/tr>\n
\u5f62\u72b6\uff0f\u7d14\u5ea6\uff0f\u4fdd\u5b58<\/strong><\/td>\n\u51cd\u7d50\u4e7e\u71e5\u3055\u308c\u305f\u767d\u8272\uff5e\u5fae\u9ec4\u767d\u8272\u306e\u7c89\u672b\u3001HPLC\u7d14\u5ea699\uff05\u4ee5\u4e0a\u3002\u77ed\u671f\u4fdd\u5b58\uff1a2\uff5e8 \u00b0C\u3001\u9577\u671f\u4fdd\u5b58\uff1a-20 \u00b0C\uff0836\u304b\u6708\u4ee5\u4e0a\uff09\u3002\u518d\u6eb6\u89e3\u5f8c\uff1a2\uff5e8 \u00b0C\u300130\u65e5\u4ee5\u5185\u306b\u4f7f\u7528\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u7528\u9014<\/strong><\/td>\n\u672c\u88fd\u54c1\u306f\u7814\u7a76\u7528\u8a66\u85ac\u3067\u3059\u3002WADA\u7981\u6b62\u30ea\u30b9\u30c8\u306b\u306f\u63b2\u8f09\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u524d\u81e8\u5e8a\u7814\u7a76\u7528\u5316\u5408\u7269\u3067\u3059\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/p>\n

\u4f5c\u7528\u6a5f\u5e8f \u2014 \u30d0\u30a4\u30a2\u30b9\u578bRXFP1\u4f5c\u52d5\u6027\uff08cAMP\u3092\u4ecb\u3055\u306a\u3044ERK\u7d4c\u8def\uff09<\/h2>\n

B7-33\u306f\u3001Florey Institute\u306eHossain\uff0fHowe\uff0fBathgate\u30b0\u30eb\u30fc\u30d7\u306b\u3088\u3063\u3066\u300cSerelaxin\u554f\u984c\u300d\u3078\u306e\u56de\u7b54\u3068\u3057\u3066\u8a2d\u8a08\u3055\u308c\u307e\u3057\u305f\u3002Serelaxin\uff08\u907a\u4f1d\u5b50\u7d44\u63db\u3048\u30d2\u30c8\u30ea\u30e9\u30ad\u30b7\u30f3-2\uff09\u306f\u6025\u6027\u5fc3\u4e0d\u5168\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7b2cIII\u76f8\u8a66\u9a13\u3092\u5b8c\u4e86\u3057\u307e\u3057\u305f\u304c\u3001FDA\u627f\u8a8d\u3092\u5f97\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f \u2014 \u305d\u306e\u4e00\u56e0\u306f\u3001RXFP1\u306e\u4e8c\u91cd\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\uff08\u6297\u7dda\u7dad\u5316ERK\u7d4c\u8def\u306f\u6709\u76ca\u3001cAMP\u7d4c\u8def\u306f\u4e0d\u6574\u8108\u8a98\u767a\u6027\u304a\u3088\u3073\u304c\u3093\u7d30\u80de\u751f\u5b58\u4fc3\u9032\u6027\u306e\u53ef\u80fd\u6027\uff09\u306b\u8d77\u56e0\u3059\u308b\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u30b7\u30b0\u30ca\u30eb\u306e\u6df7\u5728\u3067\u3057\u305f\u3002<\/p>\n

B7-33\u306e\u8a2d\u8a08\u4eee\u8aac\uff1a\u30ea\u30e9\u30ad\u30b7\u30f3 B\u9396\u5358\u72ec<\/strong> \uff08RXFP1\u7d50\u5408\u3092\u5a92\u4ecb\u3059\u308b\u9396\uff09\u306f\u3001\u5b89\u5b9a\u3057\u305f\u5358\u9396\u30da\u30d7\u30c1\u30c9\u306b\u6539\u5909\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u3001RXFP1\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306eERK1\/2\/MMP\u4e0a\u65b9\u5236\u5fa1\u306b\u3088\u308b\u6297\u7dda\u7dad\u5316\u4f5c\u7528\u306e\u307f\u3092\u6d3b\u6027\u5316\u3057\u3001cAMP\u3092\u4ecb\u3057\u305f\u767a\u304c\u3093\u4fc3\u9032\/\u4e0d\u6574\u8108\u8a98\u767a\u4f5c\u7528\u3092\u56de\u907f\u3057\u307e\u3059\u30022017\u5e74\u306b\u767a\u8868\u3055\u308c\u305fNature Communications\u306e\u8ad6\u6587\u3067\u306f\u3001B7-33\u304c\u6e2c\u5b9a\u53ef\u80fd\u306aRXFP1-ERK1\/2\u6d3b\u6027\u5316\u3092\u793a\u3059\u4e00\u65b9\u3067\u3001cAMP\u4e0a\u6607\u306f\u6700\u5c0f\u9650\u3067\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3001\u3053\u308c\u306f\u30d0\u30a4\u30a2\u30b9\u4f5c\u52d5\u85ac\u3068\u5b9a\u7fa9\u3055\u308c\u307e\u3059\u3002\u5fc3\u81d3\u7dda\u7dad\u75c7\u3001\u814e\u81d3\u7dda\u7dad\u75c7\u3001\u598a\u5a20\u9ad8\u8840\u5727\u814e\u75c7\u306e\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3001B7-33\u306f\u5929\u7136\u578b\u30ea\u30e9\u30ad\u30b7\u30f3\u3068\u6bd4\u8f03\u3057\u3066\u540c\u7b49\u4ee5\u4e0a\u306e\u6297\u7dda\u7dad\u5316\u52b9\u679c\u3092\u793a\u3057\u3001cAMP\u3092\u4ecb\u3057\u305f\u5408\u4f75\u75c7\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n

\u516c\u8868\u3055\u308c\u305f\u7814\u7a76\u7528\u9014<\/h2>\n