{"id":57504,"date":"2024-02-27T17:47:23","date_gmt":"2024-02-27T17:47:23","guid":{"rendered":"https:\/\/medsname.com\/aquazide\/"},"modified":"2026-05-01T10:49:14","modified_gmt":"2026-05-01T10:49:14","slug":"aquazide","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nb\/product\/aquazide\/","title":{"rendered":"Aquazide"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Aquazide?<\/h3>\n<p style=\"margin:0;\"><strong>Aquazide<\/strong> er en <strong>12.5 \/ 25 mg hydrochlorothiazide tablet<\/strong> fra Sun Pharma \u2014 et <strong>thiazide diuretic (benzothiadiazine sulfonamide)<\/strong> som virker p\u00e5 <strong>NCC (sodium-chloride cotransporter) in the distal convoluted tubule<\/strong>. Hydrochlorothiazide was introduced in 1959 by Merck Sharp &amp; Dohme as <strong>HydroDiuril<\/strong> &mdash; derived from sulfanilamide during the sulfonamide-antibiotic programme when its diuretic activity was noticed serendipitously. HCTZ became the reference thiazide and has been a first-line antihypertensive ever since. Half-life 6-15 hours; onset 2 hours; peak effect 4-6 hours; duration 6-12 hours. Primary indication: <strong>hypertension (first-line; guideline-recommended alongside ARB, ACEi, and CCB)<\/strong>. Typical dosing: Start 12.5 mg once daily in the morning. Target 12.5-25 mg. <strong>Do not exceed 25 mg<\/strong> for hypertension &mdash; higher doses give diminishing returns on BP but worsen metabolic side effects (urate, glucose, lipids). Modern guidelines have moved away from the historical 50 mg antihypertensive dose. Key contraindications: see full list below. Monitor electrolytes, creatinine, and glucose. <strong>Kombiner ikke med litium<\/strong> (tiazid-\/sl\u00f8yfediuretika kan utl\u00f8se litiumtoksisitet). <strong>Bruk under graviditet vurderes individuelt<\/strong> (se graviditetsmerknad). For de fleste hypertensjonspasienter fungerer diuretika best som <strong>andre eller tredje middel<\/strong> \u2014 vanligvis kombinert med en ARB, ACE-hemmer eller kalsiumkanalblokker snarere enn brukt alene.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Hva du f\u00e5r med MedsBase:<\/strong> WHO-GMP-sertifisert produsent \u00b7 Diskret emballasje \u00b7 Verdensomspennende levering \u00b7 1 400+ verifiserte <a href=\"https:\/\/medsbase.com\/nb\/reviews\/\">kundeanmeldelser<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Hver ordre er dekket av v\u00e5r <a href=\"https:\/\/medsbase.com\/nb\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 hvis pakken din ikke ankommer innen 20 virkedager, sender vi ny.<\/p>\n<h3>Hvorfor bestille fra MedsBase<\/h3>\n<p>V\u00e5re generiske legemidler kommer fra WHO-GMP-sertifiserte produsenter og sendes over hele verden i diskret, n\u00f8ytral emballasje \u2014 ingen legemiddelnavn p\u00e5 utsiden av pakken. Kortbetalinger h\u00e5ndteres av en regulert betalingsbehandler (kontoutskrifter viser en regulert kortbetalingsprosessor \u2014 aldri \u201cMedsBase\u201d eller noe legemiddelnavn). Krypto og SEPA bankoverf\u00f8rsel godtas ogs\u00e5. Hver ordre er dekket av v\u00e5r Reshipment Assurance Policy.<\/p>\n<h2 class=\"wp-block-heading\">What Is Aquazide?<\/h2>\n<p>Aquazide is an oral 12.5 \/ 25 mg hydrochlorothiazide tablet from Sun Pharma, supplied in 30-180 tablets. Hydrochlorothiazide was introduced in 1959 by Merck Sharp &amp; Dohme as <strong>HydroDiuril<\/strong> &mdash; derived from sulfanilamide during the sulfonamide-antibiotic programme when its diuretic activity was noticed serendipitously. HCTZ became the reference thiazide and has been a first-line antihypertensive ever since.<\/p>\n<h2 class=\"wp-block-heading\">How Hydrochlorothiazide Works<\/h2>\n<p>Hydrochlorothiazide inhibits the <strong>NCC (sodium-chloride cotransporter) in the distal convoluted tubule<\/strong>. De nedstr\u00f8mmende effektene:<\/p>\n<ul>\n<li><strong>Reduced sodium reabsorption<\/strong> in the distal convoluted tubule &mdash; a modest (~5%) increase in urinary sodium excretion<\/li>\n<li><strong>Volume contraction<\/strong> over the first 1-2 weeks &mdash; this is the dominant early BP-lowering mechanism<\/li>\n<li><strong>Direkte vasodilatorisk aktivitet<\/strong> developing over 2-6 weeks &mdash; the dominant long-term BP mechanism; thiazides at steady state reduce systemic vascular resistance independent of continued volume contraction<\/li>\n<li><strong>Enhanced distal-tubule calcium reabsorption<\/strong> &mdash; modestly raises serum calcium and reduces urinary calcium (exploited in calcium stone prevention)<\/li>\n<li><strong>Reduced free water clearance<\/strong> &mdash; can cause hyponatraemia in susceptible patients<\/li>\n<li><strong>Activation of the renin-angiotensin-aldosterone system<\/strong> as a compensatory response &mdash; partially blunts the BP effect of monotherapy; neutralised by combining with an ARB or ACE inhibitor (the rationale for FDCs like <a href=\"https:\/\/medsbase.com\/nb\/telma-h\/\">Telma H<\/a>, <a href=\"https:\/\/medsbase.com\/nb\/cosart-h\/\">Cosart H<\/a>)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Godkjente og evidensbaserte bruksomr\u00e5der<\/h2>\n<ul>\n<li><strong>Hypertension (first-line; guideline-recommended alongside ARB, ACEi, and CCB)<\/strong> \u2014 prim\u00e6r indikasjon<\/li>\n<li><strong>Mild heart failure oedema<\/strong> &mdash; step up to loop diuretic if not controlled<\/li>\n<li><strong>Recurrent calcium-containing kidney stones<\/strong> &mdash; 12.5-25 mg reduces calcium excretion and stone recurrence by 30-50%<\/li>\n<li><strong>Nephrogenic diabetes insipidus<\/strong> &mdash; paradoxical reduction in urine output at 25 mg BD<\/li>\n<li><strong>Osteoporose<\/strong> &mdash; modest benefit via reduced urinary calcium loss (adjunctive only)<\/li>\n<\/ul>\n<p><strong>Avgj\u00f8rende studieresultater:<\/strong> <strong>ALLHAT (2002)<\/strong> &mdash; chlorthalidone (a close thiazide analogue) non-inferior to amlodipine and lisinopril for fatal and nonfatal cardiovascular endpoints in &gt;33,000 hypertensive patients; cemented thiazides as a first-line option. <strong>SHEP (1991)<\/strong> &mdash; chlorthalidone-based therapy reduced stroke by 36% in isolated systolic hypertension of the elderly. <strong>MRFIT, HDFP<\/strong> (1970s-80s) &mdash; earlier evidence base. HCTZ-specific large-scale hard-outcome data is weaker than chlorthalidone&rsquo;s but class effect is presumed.<\/p>\n<h2 class=\"wp-block-heading\">Aquazide Dosage<\/h2>\n<p><strong>Dosering ved hypertensjon:<\/strong> Start 12.5 mg once daily in the morning. Target 12.5-25 mg. <strong>Do not exceed 25 mg<\/strong> for hypertension &mdash; higher doses give diminishing returns on BP but worsen metabolic side effects (urate, glucose, lipids). Modern guidelines have moved away from the historical 50 mg antihypertensive dose.<\/p>\n<p><strong>Andre indikasjoner:<\/strong> <strong>Mild heart failure oedema:<\/strong> 25-50 mg\/day; escalate to loop diuretic (furosemide) if not controlled. <strong>Idiopathic hypercalciuria (recurrent calcium stones):<\/strong> 12.5-25 mg\/day &mdash; thiazides promote distal-tubule calcium reabsorption and reduce stone recurrence by 30-50%. <strong>Nephrogenic diabetes insipidus:<\/strong> 25 mg twice daily paradoxically reduces urine output.<\/p>\n<p><strong>Administrering:<\/strong> en gang daglig (eller to ganger daglig ved h\u00f8ye doser av sl\u00f8yfediumidika ved hjertesvikt), om morgenen. Kveldsdosering for\u00e5rsaker nokturi og b\u00f8r unng\u00e5s n\u00e5r mulig. Ta til samme tid hver dag. Mat p\u00e5virker ikke opptaket av disse diuretikaene signifikant.<\/p>\n<p><strong>Overv\u00e5kingsplan:<\/strong><\/p>\n<ul>\n<li><strong>Utgangspunkt:<\/strong> urinstoff, elektrolytter (spesielt kalium og natrium), kreatinin, eGFR, glukose, serumurat. Hjemme- eller klinikk-blodtrykk og daglig vekt for hjertesviktpasienter.<\/li>\n<li><strong>1-2 uker etter start eller doseendring:<\/strong> gjenta U&amp;E og kreatinin. Forvent milde elektrolyttendringer; unders\u00f8k betydelige endringer.<\/li>\n<li><strong>4-6 uker:<\/strong> Blodtrykkvurdering og fullt metabolsk panel.<\/li>\n<li><strong>L\u00f8pende:<\/strong> \u00e5rlig U&amp;E, urat, glukose og lipidpanel n\u00e5r stabilisert. Hyppigere ved CKD, HF eller ved kombinasjonsterapi.<\/li>\n<li><strong>Stopp eller reduser dose ved:<\/strong> natrium &lt;130 med symptomer, kalium 5,5, kreatinin\u00f8kning &gt;30%, ny gikt, alvorlige dehydreringssymptomer.<\/li>\n<\/ul>\n<p><strong>Avslutning:<\/strong> ingen abstinenssyndrom, men plutselig stopp kan for\u00e5rsake rebound v\u00e6skeretensjon hos HF-pasienter p\u00e5 kronisk h\u00f8ydose sl\u00f8yfediuretika \u2014 trapp ned der mulig og overv\u00e5k vekt.<\/p>\n<ul>\n<li><strong>Loses efficacy at eGFR &lt;30.<\/strong> Switch to a loop diuretic (furosemide, torasemide) at advanced CKD &mdash; thiazides need functioning distal-tubule sodium delivery.<\/li>\n<li><strong>Raises serum calcium<\/strong> (paradoxical: thiazides enhance distal calcium reabsorption). Useful in osteoporotic patients; problematic in hypercalcaemic conditions (primary hyperparathyroidism, sarcoidosis).<\/li>\n<li><strong>Fotosensitivitetsutslag<\/strong> is a specific thiazide class effect &mdash; counsel sun protection in sunny regions.<\/li>\n<li><strong>Sulfonamide cross-reactivity<\/strong> &mdash; avoid if severe sulfa allergy (rare; non-antibiotic sulfonamides rarely cross-react).<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Bivirkninger<\/h2>\n<p><strong>Vanlige (&gt;1%):<\/strong><\/p>\n<ul>\n<li><strong>Hypokalemi<\/strong> (3-5%) &mdash; more common at doses &gt;25 mg; largely prevented when combined with an ACEi\/ARB<\/li>\n<li><strong>Hyponatremi<\/strong> (2-5%) &mdash; especially in elderly women on low-salt diets; can be severe<\/li>\n<li><strong>Hyperurikemi<\/strong> and gout precipitation<\/li>\n<li><strong>Modest worsening of glucose tolerance<\/strong> (fasting glucose +5-8 mg\/dL average)<\/li>\n<li><strong>Mild LDL and triglyceride rise<\/strong><\/li>\n<li><strong>Erektil dysfunksjon<\/strong> in some men &mdash; dose-related<\/li>\n<li><strong>Hyperkalsemi<\/strong> (usually mild)<\/li>\n<li><strong>Fotosensitivitetsutslag<\/strong><\/li>\n<\/ul>\n<p><strong>Uvanlig, men klinisk viktig:<\/strong><\/p>\n<ul>\n<li><strong>Alvorlig hyponatremi<\/strong> \u2014 spesielt hos eldre med lavtsaltdieter, SIADH-tilstander, eller kombinert med SSRI. Kan manifestere seg som forvirring, fall eller kramper.<\/li>\n<li><strong>Pankreatitt<\/strong> \u2014 sjelden tiazid-\/sl\u00f8yfeklasseeffekt; stopp umiddelbart ved \u00f8vre magesmerter med lipasestigning<\/li>\n<li><strong>Trombocytopeni, leukopeni, agranulocytose<\/strong> \u2014 sjeldne hypersensitivitetsreaksjoner (vanligere med tiazider enn sl\u00f8yfedrivende midler)<\/li>\n<li><strong>Akutt myopi og vinkelblokkglaukom<\/strong> \u2014 sjelden sulfonamidklassereaksjon innen timer til dager etter start; stopp umiddelbart ved plutselig smertefullt \u00f8ye eller synsendring<\/li>\n<li><strong>Stevens-Johnson-syndrom \/ toksisk epidermal nekrolyse<\/strong> \u2014 ekstremt sjelden, men rapportert<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Kontraindikasjoner<\/h2>\n<ul>\n<li>Anuria or severe renal impairment (eGFR &lt;30) &mdash; loses efficacy<\/li>\n<li>Sulfonamide (sulfa) hypersensitivity<\/li>\n<li>Symptomatic hyponatraemia (Na &lt;130) or hypokalaemia (K &lt;3.0) at baseline<\/li>\n<li>Hyperkalsemi<\/li>\n<li>Alvorlig leversvikt (Child-Pugh C)<\/li>\n<li>Addison disease (primary adrenal insufficiency)<\/li>\n<\/ul>\n<p><strong>Graviditet:<\/strong> vanligvis unng\u00e5s \u2014 tiazider krysser placenta og kan for\u00e5rsake foster- eller nyf\u00f8dtgulsott og trombocytopeni. Bruk kun hvis nytte klart oppveier risiko (resistente h\u00f8yt blodtrykk i svangerskapets siste fase), under spesialistbehandling.<\/p>\n<p><strong>Amming:<\/strong> vanligvis akseptabelt i lave doser; h\u00f8ye doser kan redusere melkeproduksjonen (spesielt tiazider). Alternative antihypertensiva (propranolol, nifedipin) foretrekkes n\u00e5r mulig.<\/p>\n<h2 class=\"wp-block-heading\">Legemiddelinteraksjoner<\/h2>\n<ul>\n<li><strong>Litium \u2014 KRITISK INTERAKSJON.<\/strong> Tiazid- og sl\u00f8yfediuretika reduserer litiums renale klaring og kan utl\u00f8se litiumtoksisitet. Unng\u00e5 kombinasjon hvis mulig; hvis det er uunng\u00e5elig, overv\u00e5k litiumniv\u00e5er ukentlig den f\u00f8rste m\u00e5neden og reduser litiumdosen med 25-50%.<\/li>\n<li><strong>NSAID-er<\/strong> \u2014 reduserer diuretisk effekt (via prostaglandinblokkade) og \u00f8ker betydelig risiko for akutt nyreskade (AKI) n\u00e5r kombinert med ACE-hemmere\/ARB (den \u201ctriple whammy\u201d). Bruk paracetamol som f\u00f8rstevalg ved kroniske smerter.<\/li>\n<li><strong>ACE-hemmere og ARB<\/strong> \u2014 kombinasjonen er standard og gunstig ved h\u00f8yt blodtrykk; tillegg av ACE-hemmer\/ARB blokkerer kompensatorisk RAAS-aktivering og forsterker den diuretiske effekten. Overv\u00e5k kalium og kreatinin.<\/li>\n<li><strong>Kaliumtilskudd og kaliumsparende diuretika<\/strong> \u2014 ofte n\u00f8dvendig for \u00e5 motvirke hypokalemi for\u00e5rsaket av loop-\/tyaziddiuretika. Overv\u00e5k kalium; unng\u00e5 overkorrigering.<\/li>\n<li><strong>Digoxin<\/strong> \u2014 hypokalemi forsterker digoksintoksisteten (loop- og tyaziddiuretika); spironolakton reduserer direkte digoksinklaringen. Overv\u00e5k digoksinniv\u00e5er og kalium ved start eller endring av diuretika.<\/li>\n<li><strong>Orale kortikosteroider, amfotericin B, stimulerende avf\u00f8ringsmidler<\/strong> \u2014 additiv hypokalemi (loop\/tyazid) eller maskert kaliumbehov (spironolakton).<\/li>\n<li><strong>Orale antidiabetika, insulin<\/strong> \u2014 tyazider og (i mindre grad) loop-diuretika forverrer glukosetoleransen; kan kreve dosejustering.<\/li>\n<li><strong>Kolestyramin \/ kolestipol<\/strong> \u2014 reduserer opptaket av tyazider og loop-diuretika med 40-85%. Separer dosering med 4 timer.<\/li>\n<li><strong>Alkohol<\/strong> \u2014 additiv postural hypotensjon.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Where Aquazide Fits in the Diuretic Class<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Klasse<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Representanter<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Typisk bruk<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff3cd;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Thiazid<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><a href=\"https:\/\/medsbase.com\/nb\/aquazide\/\">HCTZ<\/a>, chlortalidon<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">F\u00f8rstelinje ved HTN, nyrestein, nefrogen DI<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Thiazid-lignende<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><a href=\"https:\/\/medsbase.com\/nb\/natrilix-sr\/\">Indapamid<\/a>, metolazon<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">HTN (eldre, HYVET-dokumentert), sekvensiell nefronblokkering<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Loop (kortvarig)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><a href=\"https:\/\/medsbase.com\/nb\/lasix\/\">Furosemid<\/a>, bumetanid<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Akutt lunge\u00f8dem, CHF, ascites, hyperkalc\u00e6mi<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Loop (langvarig)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><a href=\"https:\/\/medsbase.com\/nb\/dytor\/\">Torasemid<\/a><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Kronisk CHF, HTN (eneste loop med dokumentert effekt ved HTN), \u00f8dem ved CKD<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Aldosteronantagonist<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><a href=\"https:\/\/medsbase.com\/nb\/aldactone\/\">Spironolacton<\/a>, eplerenone<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">HF-REF (RALES), resistent HTN (PATHWAY-2), Conn\u2019s, cirrotisk ascites<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Andre K-sparende<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Amilorid, triamteren (vanligvis i kombinasjoner)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Forebygging av hypokalemi n\u00e5r det tilsettes loop\/thiazid<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Karbonsyreanhydrase<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Acetazolamid<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">H\u00f8ydekreft, glaukom, metabolsk alkalose<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Oppbevaring<\/h2>\n<p>Store Aquazide below 25&deg;C in the original blister pack. Keep out of reach of children.<\/p>\n<h2 id=\"faqs\">Vanlige sp\u00f8rsm\u00e5l<\/h2>\n<h3 class=\"wp-block-heading\">When should I take Aquazide &mdash; morning or evening?<\/h3>\n<p><strong>Morgen<\/strong> in almost all cases. The diuretic effect produces increased urine output for 2-4 hours after dosing. Evening dosing causes nocturia and disrupts sleep. Patients on twice-daily loop diuretics typically dose at breakfast and early afternoon (not bedtime).<\/p>\n<h3 class=\"wp-block-heading\">Is Aquazide a first-line blood-pressure drug?<\/h3>\n<p>Ja \u2014 tiazider (HCTZ, klortalidon) og tiazid-lignende midler (indapamid) er en av <strong>de fire f\u00f8rstelinje antihypertensive klasser<\/strong> sammen med ARBer, ACE-hemmere og kalsiumkanalblokkere. For de fleste nyoppdagede hypertensivpasienter er et tiazid et rimelig f\u00f8rste eller andre valg, og nesten alle pasienter p\u00e5 en flermedikamentregime inkluderer et.<\/p>\n<h3 class=\"wp-block-heading\">Will Aquazide affect my potassium?<\/h3>\n<p>Yes &mdash; Aquazide <strong>senker<\/strong> kalium ved \u00e5 \u00f8ke kaliumutsondringen i distale tubuli. Overv\u00e5k ved start, etter 1-2 uker og periodisk. Hypokalemirisiko <strong>minimeres ved \u00e5 kombinere<\/strong> Aquazide with an ARB or ACE inhibitor &mdash; which is the standard combination in hypertension anyway. If potassium drops below 3.5 in isolated diuretic use, add potassium supplementation, a potassium-rich diet, or a small dose of a potassium-sparing agent (spironolactone, eplerenone, or an <a href=\"https:\/\/medsbase.com\/nb\/amifru\/\">amiloridholdig kombinasjon<\/a>).<\/p>\n<h3 class=\"wp-block-heading\">I have gout &mdash; can I take Aquazide?<\/h3>\n<p>Med forsiktighet. Tiazider og (i mindre grad) sl\u00f8yfediuretika \u00f8ker serumurinsyre ved \u00e5 konkurrere om ekskresjon i proximale tubuli. Hos giktutl\u00f8ste pasienter: foretrekk losartanbaserte kombinasjoner (<a href=\"https:\/\/medsbase.com\/nb\/cosart-h\/\">Cosart H<\/a>, <a href=\"https:\/\/medsbase.com\/nb\/cozartan-h\/\">Cozartan H<\/a>) whose losartan component is uniquely uricosuric and offsets the thiazide urate rise. If Aquazide is already in use and gout flares, add or continue urate-lowering therapy (allopurinol) rather than stopping Aquazide outright.<\/p>\n<h3 class=\"wp-block-heading\">I&rsquo;m diabetic &mdash; is Aquazide safe?<\/h3>\n<p>Mostly yes, but be aware that thiazides and (to a lesser extent) loop diuretics <strong>modestly worsen glucose tolerance<\/strong> (average fasting glucose rise 5-8 mg\/dL, HbA1c 0.1-0.3%). The BP benefit outweighs this in most diabetics. If you want a more metabolically neutral combination, ARB+CCB is an alternative (<a href=\"https:\/\/medsbase.com\/nb\/olmezest-am\/\">Olmezest AM<\/a>).<\/p>\n<h3 class=\"wp-block-heading\">Can I take ibuprofen with Aquazide?<\/h3>\n<p>Kortvarig bruk av og til er vanligvis greit. Langvarig daglig bruk av NSAID-er (ibuprofen, diklofenak, naproxen) <strong>reduserer diuretisk og antihypertensiv effekt<\/strong> of Aquazide (prostaglandin blockade) and substantially raise the AKI risk when combined with an ACE inhibitor or ARB &mdash; the &#8220;triple whammy.&#8221; Use paracetamol preferentially for chronic pain.<\/p>\n<h3 class=\"wp-block-heading\">M\u00e5 jeg tisse mer om natten?<\/h3>\n<p>Usually no, if you take Aquazide in the morning. The diuretic effect peaks 2-4 hours after dosing and has mostly worn off by evening. Nocturia is a common complaint when patients switch to evening dosing; switch back to morning dosing and nocturia resolves within 1-3 days.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Aquazide in pregnancy?<\/h3>\n<p>Routinely avoided. Thiazides cross the placenta and can affect the fetus. For hypertension in pregnancy, switch to <a href=\"https:\/\/medsbase.com\/nb\/labebet\/\">labetalol<\/a>, metyldopa eller nifedipin. Diuretika brukes under svangerskap kun for spesifikke indikasjoner (lunge\u00f8dem, resistent hjertesvikt) under spesialistveiledning.<\/p>\n<h3 class=\"wp-block-heading\">Hva om jeg glemmer en dose?<\/h3>\n<p>Ta den s\u00e5 snart du husker det, med mindre det er nesten tid for neste dose \u2014 i s\u00e5 fall hopp over den glemte dosen. Ikke ta dobbel dose. En enkelt glemt dose p\u00e5virker ikke langtidskontrollen av blodtrykk eller v\u00e6ske balanse betydelig.<\/p>\n<h3 class=\"wp-block-heading\">Where can I buy Aquazide online?<\/h3>\n<p>You can buy Aquazide (12.5 \/ 25 mg hydrochlorothiazide, 30-180 tablets) from MedsBase with discreet packaging and worldwide shipping.<\/p>\n<h2 class=\"wp-block-heading\">Relaterte antihypertensiva og diuretika p\u00e5 MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nb\/aldactone\/\">Aldactone \u2014 Spironolakton 25 mg (aldosteronantagonist)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/cosart-h\/\">Cosart H &mdash; Losartan + HCTZ fixed combination<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/dytor\/\">Dytor \u2014 Torasemid (sl\u00f8yfe, mer forutsigbar biotilgjengelighet)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/hydrocl\/\">Hydrocl \u2014 Hydrochlorothiazide (HCTZ)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/losar\/\">Losar \u2014 Losartan (ARB-partner for diuretikum)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/telma-h\/\">Telma H &mdash; Telmisartan + HCTZ fixed combination<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/high-blood-pressure-medication\/\"><strong>Se alle h\u00f8yt blodtrykksmedikamenter<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Medisinsk ansvarsfraskrivelse.<\/strong> Denne siden er kun til informasjonsform\u00e5l og erstatter ikke medisinsk r\u00e5dgivning fra en kvalifisert helsepersonell. H\u00f8yt blodtrykk, hjertesvikt og arytmier krever diagnose, overv\u00e5kning og dosindividualisering av en lege \u2013 bruk alltid betablokkere under medisinsk veiledning.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Relaterte alternativer<\/h3>\n<p>Andre produkter innen <strong>Kroniske tilstander<\/strong> som kunder ogs\u00e5 ser p\u00e5:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nb\/flexabenz\/\">Flexabenz<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/hivus-lr\/\">Hivus LR<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/combutol\/\">Combutol<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/glynase-xl\/\">Glynase Xl<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/cytotam\/\">Cytotam<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Aquazide is Sun Pharma&#8217;s hydrochlorothiazide 12.5\/25 mg tablets \u2014 the reference thiazide diuretic and one of the four guideline-recommended first-line antihypertensive classes. Blocks sodium reabsorption in the distal tubule; modest direct vasodilator activity develops over 2-6 weeks. Modern guidelines prefer low-dose 12.5-25 mg to limit metabolic side effects. ALLHAT and SHEP trial evidence.<\/p>","protected":false},"featured_media":57505,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3260,3356],"product_tag":[4317,3401],"class_list":{"0":"post-57504","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-heart-blood-pressure","9":"product_cat-high-blood-pressure-medication","10":"product_tag-aquazide","11":"product_tag-hydrochlorothiazide","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product\/57504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/comments?post=57504"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/media\/57505"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/media?parent=57504"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product_brand?post=57504"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product_cat?post=57504"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product_tag?post=57504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}