{"id":57618,"date":"2024-02-27T17:52:50","date_gmt":"2024-02-27T17:52:50","guid":{"rendered":"https:\/\/medsname.com\/inmecin\/"},"modified":"2026-05-01T10:49:14","modified_gmt":"2026-05-01T10:49:14","slug":"inmecin","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nb\/product\/inmecin\/","title":{"rendered":"Inmecin"},"content":{"rendered":"

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⚡ Quick Answer — What is Inmecin?<\/h3>\n

Inmecin<\/strong> er en indomethacin capsule<\/strong> tilgjengelig i 25 mg and 50 mg<\/strong> strengths. Indomethacin is one of the most potent non-selective NSAIDs and is first-line for acute gout, pericarditis, ankylosing spondylitis, and Bartter syndrome<\/strong>. The usual adult dose is 25–50 mg two to three times daily with food<\/strong>. Indomethacin has a stronger CNS side-effect profile (headache, dizziness) than ibuprofen or diclofenac, and should be used at the lowest effective dose for the shortest reasonable time.<\/p>\n<\/div>\n

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Hvorfor bestille fra MedsBase<\/h3>\n

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Inmecin<\/strong> is an immediate-release oral capsule containing indomethacin<\/strong>, a powerful non-selective NSAID developed in 1963. Indomethacin is on the WHO Essential Medicines List and remains the gold-standard oral NSAID for several specific indications where its unusually strong anti-inflammatory effect outweighs its relatively higher side-effect burden compared to newer NSAIDs.<\/p>\n

To kapselstyrker er tilgjengelige:<\/p>\n

    \n
  • Inmecin 25 mg<\/strong> — starting and maintenance dose, especially in older patients<\/li>\n
  • Inmecin 50 mg<\/strong> — for more severe inflammatory pain; acute gout and pericarditis commonly need this strength<\/li>\n<\/ul>\n

    What Is Inmecin Used For?<\/h2>\n
      \n
    • Akutt gikt<\/strong> — gold-standard oral NSAID for a gout flare; higher-dose 50 mg TID for 2–3 days then taper<\/li>\n
    • Rheumatoid arthritis and osteoarthritis<\/strong> — when other NSAIDs are inadequate<\/li>\n
    • Ankyloserende spondylitt<\/strong> — first-line NSAID in many guidelines<\/li>\n
    • Pericarditis<\/strong> — a first-line oral NSAID, usually combined with colchicine<\/li>\n
    • Reactive arthritis, psoriatic arthritis<\/strong> — inflammatory spondyloarthritides<\/li>\n
    • Pseudogout (calcium pyrophosphate deposition)<\/strong> — acute flare<\/li>\n
    • Patent ductus arteriosus (PDA) closure in neonates<\/strong> — hospital setting only<\/li>\n
    • Bartter syndrome and Gitelman syndrome<\/strong> — to reduce renal prostaglandin overproduction<\/li>\n
    • Prim\u00e6r dysmenorr\u00e9<\/strong> — second-line<\/li>\n<\/ul>\n

      How Does Indomethacin Work?<\/h2>\n

      Indomethacin is a ikke-selektivt NSAID<\/strong> \u2014 det blokkerer b\u00e5de COX-1<\/strong> (som opprettholder mageslimhinnen, blodplatenes funksjon og nyreperfusjon) og COX-2<\/strong> (som er oppregulert ved inflammasjonssteder). Denne brede virkningen forklarer b\u00e5de dens sterke antiinflammatoriske effekt og dens velkjente bivirkningsprofil i mage-tarmkanalen og nyrene.<\/p>\n

      Den terapeutiske hendelseskjeden er den samme for alle NSAID-er:<\/p>\n

        \n
      1. Vevsskade eller betennelse frigj\u00f8r fosfolipider fra cellemembraner<\/li>\n
      2. Fosfolipase A\u2082 omdanner dem til arakidonsyre<\/li>\n
      3. Syklooksygenase (COX-1\/COX-2) omdanner arakidonsyre til prostaglandiner<\/strong> \u2014 molekylene som er ansvarlige for smerte, hevelse og feber<\/li>\n
      4. Indomethacin blocks the COX enzymes, so less prostaglandin is produced, so there is less pain and inflammation<\/li>\n<\/ol>\n

        Siden prostaglandiner ogs\u00e5 beskytter mageslimhinnen, regulerer nyreblodstr\u00f8mmen og p\u00e5virker blodplatefunksjonen, er den samme mekanismen som lindrer smerte ogs\u00e5 ansvarlig for hovedbivirkningene ved NSAID-er: mageirritasjon, v\u00e6skeansamling, h\u00f8yt blodtrykk og (hos enkelte) nyrebelastning.<\/p>\n

        Inmecin Dosing<\/h2>\n
          \n
        • Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis:<\/strong> 25 mg two or three times daily; may increase to 50 mg TID if needed. Maximum 200 mg\/day (rarely justified).<\/li>\n
        • Akutt gikt:<\/strong> 50 mg three times daily for 2 days, then 25 mg TID for a further 2–3 days, then stop.<\/li>\n
        • Pericarditis:<\/strong> 25–50 mg three times daily for 2 weeks, tapering thereafter, alongside colchicine.<\/li>\n
        • Primary dysmenorrhoea:<\/strong> 25 mg three times daily from onset of pain for 2–3 days.<\/li>\n<\/ul>\n

          Always take with food or an antacid to reduce gastric irritation. Swallow capsules whole with a full glass of water. Do not lie down for at least 15 minutes after a dose (reduces oesophageal irritation).<\/p>\n

          Because indomethacin has a 4-hour half-life, three-times-daily dosing is standard. For a simpler once-daily or twice-daily schedule, a sustained-release formulation such as Inmecin-R 75 mg<\/strong> is available.<\/p>\n

          \n

          GI-sikkerhet \u2014 les dette f\u00f8r f\u00f8rste dose.<\/strong> Every NSAID, including Inmecin, carries a real risk of gastritis, peptic ulcer, and upper-GI bleeding. The risk is highest in patients over 65, in those with prior ulcer disease, and in anyone also taking low-dose aspirin, corticosteroids, SSRIs, or anticoagulants. Take Inmecin med mat<\/em>, bruk den laveste effektive dosen i kortest mulig tid<\/em>, og sp\u00f8r legen din om samtidig forskrivning av en protonpumpehemmer (omeprazol, pantoprazol) hvis du trenger det i mer enn 2\u20134 uker.<\/p>\n<\/div>\n

          Who Should Not Take Inmecin?<\/h2>\n