{"id":58015,"date":"2024-02-27T18:12:30","date_gmt":"2024-02-27T18:12:30","guid":{"rendered":"https:\/\/medsname.com\/etibo\/"},"modified":"2026-04-30T10:17:00","modified_gmt":"2026-04-30T10:17:00","slug":"etibo","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nb\/product\/etibo\/","title":{"rendered":"Etibo"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 8px 0;\"><strong>\ud83d\udca1 Raskt svar<\/strong><\/p>\n<p style=\"margin:0;\"><strong>Etibo<\/strong> is <strong>lapatinib 250 mg<\/strong>, en <strong>dual HER2\/EGFR tyrosine kinase inhibitor<\/strong> for advanced or metastatic <strong>HER2-positive breast cancer<\/strong>. Oral once-daily therapy combined with capecitabine or other regimens, usually after trastuzumab (Herceptin) failure. Significant side effects include diarrhoea, rash, and cardiotoxicity; requires close oncologist supervision and ECG monitoring.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Hva du f\u00e5r med MedsBase:<\/strong> WHO-GMP-sertifisert produsent \u00b7 Diskret emballasje \u00b7 Verdensomspennende levering \u00b7 1 400+ verifiserte <a href=\"https:\/\/medsbase.com\/nb\/reviews\/\">kundeanmeldelser<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Hver ordre er dekket av v\u00e5r <a href=\"https:\/\/medsbase.com\/nb\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 hvis pakken din ikke ankommer innen 20 virkedager, sender vi ny.<\/p>\n<h3>Hvorfor bestille fra MedsBase<\/h3>\n<p>V\u00e5re generiske legemidler kommer fra WHO-GMP-sertifiserte produsenter og sendes over hele verden i diskret, n\u00f8ytral emballasje \u2014 ingen legemiddelnavn p\u00e5 utsiden av pakken. Kortbetalinger h\u00e5ndteres av en regulert betalingsbehandler (kontoutskrifter viser en regulert kortbetalingsprosessor \u2014 aldri \u201cMedsBase\u201d eller noe legemiddelnavn). Krypto og SEPA bankoverf\u00f8rsel godtas ogs\u00e5. Hver ordre er dekket av v\u00e5r Reshipment Assurance Policy.<\/p>\n<div style=\"background:#f4f8fb;border-left:4px solid #2c7cb0;padding:14px 20px;margin:16px 0;border-radius:4px;font-size:0.95em;\">\n<strong>\ud83d\udd12 Hvorfor bestille fra MedsBase:<\/strong> Verifisert ekte produsentforsyning \u00b7 Global levering \u00b7 Sikker betaling (kredittkort, krypto) \u00b7 Vurdert 4.9\u2605 av 1 400+ kunder\n<\/div>\n<h2><strong>What Is Etibo?<\/strong><\/h2>\n<p>Etibo is a branded generic of <strong>lapatinib<\/strong> 250 mg, a small-molecule tyrosine kinase inhibitor that targets <strong>HER2 (ErbB2)<\/strong> og <strong>EGFR (ErbB1)<\/strong>. Lapatinib blocks intracellular signaling downstream of these receptors, halting proliferation of HER2-positive cancer cells. Manufactured by Natco Pharma.<\/p>\n<p><strong>Kritisk:<\/strong> Lapatinib is an oncology drug used only under specialist supervision. It is not a general women&#8217;s health product. Use strictly according to oncologist protocol \u2014 typically after trastuzumab resistance develops.<\/p>\n<h2><strong>Klinisk bruk<\/strong><\/h2>\n<ul>\n<li><strong>Advanced\/metastatic HER2+ breast cancer<\/strong>: 1250 mg daily (5 tablets) + capecitabine \u2014 after trastuzumab failure.<\/li>\n<li><strong>HER2+ breast cancer with letrozole<\/strong> in postmenopausal women with ER+\/HER2+ metastatic disease.<\/li>\n<li><strong>Ikke indikert<\/strong> for adjuvant (early-stage curative) therapy \u2014 trastuzumab \u00b1 pertuzumab remain standard there.<\/li>\n<\/ul>\n<h2><strong>Hvordan ta<\/strong><\/h2>\n<ol>\n<li>Ta <strong>1250 mg (5 tablets) once daily<\/strong>, <strong>at least 1 hour before or after food<\/strong>. Food significantly increases absorption and shifts dosing parameters; consistency matters.<\/li>\n<li>Typical partner drug: capecitabine 2000 mg\/m\u00b2\/day on days 1\u201314 of a 21-day cycle.<\/li>\n<li>ECG and LVEF monitoring at baseline and every 3 months (cardiotoxicity risk).<\/li>\n<li>Manage diarrhoea proactively \u2014 often grade 1\u20133, common in first cycle. Loperamide, hydration, dose reduction as needed.<\/li>\n<li>Avoid grapefruit, Seville oranges, and CYP3A4 inhibitors\/inducers.<\/li>\n<\/ol>\n<h2><strong>Bivirkninger<\/strong><\/h2>\n<p><strong>Meget vanlig:<\/strong> diarrhoea (60\u201380%), rash (40\u201360%), nausea, vomiting, fatigue, hand-foot syndrome, palmar-plantar erythrodysesthesia (with capecitabine combo).<\/p>\n<p><strong>Alvorlige:<\/strong> <strong>hepatotoxicity<\/strong> (monitor LFTs), <strong>cardiotoxicity \/ reduced LVEF<\/strong> (5\u20136%), QT prolongation, interstitial lung disease (rare but serious).<\/p>\n<p><strong>Alvorlige:<\/strong> severe liver injury, heart failure, severe skin reactions (Stevens-Johnson), pulmonary toxicity.<\/p>\n<h2><strong>Who Should Not Take Etibo<\/strong><\/h2>\n<ul>\n<li>HER2-negative breast cancer (ineffective)<\/li>\n<li>Alvorlig leversvikt<\/li>\n<li>Symptomatic heart failure or severe cardiac dysfunction<\/li>\n<li>Pregnancy \u2014 teratogenic<\/li>\n<li>Concurrent strong CYP3A4 inhibitors or inducers without dose adjustment<\/li>\n<\/ul>\n<h2><strong>Legemiddelinteraksjoner<\/strong><\/h2>\n<ul>\n<li><strong>Sterke CYP3A4-hemmere<\/strong> (ketoconazole, ritonavir, clarithromycin, grapefruit): raise lapatinib levels significantly.<\/li>\n<li><strong>Sterke CYP3A4-indusere<\/strong> (rifampicin, carbamazepine, phenytoin, St John&#8217;s Wort): reduce lapatinib levels and efficacy.<\/li>\n<li><strong>PPIs, H2 blockers<\/strong>: reduce absorption \u2014 avoid or space by hours.<\/li>\n<li><strong>Warfarin, digoxin<\/strong>: may increase levels.<\/li>\n<\/ul>\n<h2><strong>Oppbevaring<\/strong><\/h2>\n<p>Store at room temperature (15\u201330 \u00b0C), away from moisture. Keep in original packaging. Keep out of reach of children.<\/p>\n<h2 id=\"faqs\">Vanlige sp\u00f8rsm\u00e5l<\/h2>\n<h3 class=\"wp-block-heading\">When is lapatinib used?<\/h3>\n<p>Advanced\/metastatic HER2-positive breast cancer, typically after trastuzumab (Herceptin) resistance. Not used for early-stage curative therapy.<\/p>\n<h3 class=\"wp-block-heading\">Why take on empty stomach?<\/h3>\n<p>Food increases lapatinib absorption 4\u20135\u00d7, making dosing unpredictable. Standard is consistent fasting \u2014 1 hour before or after food \u2014 at a fixed time each day.<\/p>\n<h3 class=\"wp-block-heading\">How bad is the diarrhoea?<\/h3>\n<p>Common, often grade 1\u20132; manageable with loperamide and hydration. Grade 3+ diarrhoea may require treatment interruption and dose reduction. Report early.<\/p>\n<h3 class=\"wp-block-heading\">Will lapatinib damage my heart?<\/h3>\n<p>About 5\u20136% of patients have asymptomatic LVEF drops. ECG + echocardiogram at baseline and every 3 months. Usually reversible on dose adjustment or interruption.<\/p>\n<h3 class=\"wp-block-heading\">Can I take lapatinib with trastuzumab?<\/h3>\n<p>Combination lapatinib + trastuzumab is used in specific protocols. Not routine without oncologist supervision.<\/p>\n<h3 class=\"wp-block-heading\">What about fertility?<\/h3>\n<p>Effective contraception required during treatment and for 1 week after (teratogenic). Men should use effective contraception during and 3 months after.<\/p>\n<h3 class=\"wp-block-heading\">Why is this in the Women&#039;s Health category?<\/h3>\n<p>HER2+ breast cancer disproportionately affects women (though rarely men get HER2+ breast cancer). Categorisation reflects the population, not a strict clinical cluster.<\/p>\n<h3 class=\"wp-block-heading\">Is lapatinib still first-line?<\/h3>\n<p>For second-line HER2+ metastatic disease (after trastuzumab), lapatinib + capecitabine was standard for years. Newer options (T-DM1\/Kadcyla, T-DXd\/Enhertu, tucatinib) have since largely supplanted it in first-world oncology \u2014 lapatinib remains important where newer agents are unavailable.<\/p>\n<h3 class=\"wp-block-heading\">Relaterte produkter for kvinners helse<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nb\/tamodex\/\">Tamodex (Tamoxifen 10 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/tamilong\/\">Tamilong (Tamoxifen 20 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/letroheal\/\">Letroheal (Letrozol 2,5 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/duphaston\/\">Duphaston (Dydrogesteron 10 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/deviry\/\">Deviry (Medroxyprogesteron 10 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/naprosyn\/\">Naprosyn (Naproxen 250 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/candid-v-gel\/\">Candid-V Gel (Clotrimazole)<\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 20px;margin:16px 0;border-radius:4px;font-size:0.9em;\">\n<p style=\"margin:0;\"><strong>\u2695\ufe0f Medisinsk ansvarsfraskrivelse:<\/strong> Informasjonen er veiledende og erstatter ikke medisinsk r\u00e5dgivning. Konsulter en lege f\u00f8r du starter, stopper eller endrer medisiner, spesielt ved kreftbehandling, hormonbehandlinger og reseptbelagte produkter.<\/p>\n<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Relaterte alternativer<\/h3>\n<p>Andre onkologimedikamenter vi f\u00f8rer sammen med dette produktet:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nb\/verpin\/\">Verpin<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/triohale-rotacaps\/\">Triohale Rotacaps<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/inderal\/\">Inderal<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/hydrocl\/\">Hydrocl<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/ezedoc\/\">Ezedoc<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Targets cancer cells<br \/>\n\u2705 Inhibits tumor growth<br \/>\n\u2705 Treats breast cancer<br \/>\n\u2705 Blocks HER2 receptors<br \/>\n\u2705 Forbedrer overlevelsessatser<\/p>\n<p>Etibo contains Lapatinib.<\/p>","protected":false},"featured_media":58016,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223,3502],"product_tag":[4402,4403],"class_list":{"0":"post-58015","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_cat-womens-health","10":"product_tag-etibo","11":"product_tag-lapatinib","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product\/58015","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/comments?post=58015"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/media\/58016"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/media?parent=58015"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product_brand?post=58015"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product_cat?post=58015"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product_tag?post=58015"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}