{"id":58253,"date":"2024-02-27T18:25:21","date_gmt":"2024-02-27T18:25:21","guid":{"rendered":"https:\/\/medsname.com\/atlura\/"},"modified":"2026-04-30T10:24:16","modified_gmt":"2026-04-30T10:24:16","slug":"atlura","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nb\/product\/atlura\/","title":{"rendered":"Atlura"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div class=\"medsbase-tldr-answer\" style=\"background:#fff8d6;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">\u26a1 Raskt svar<\/h3>\n<p style=\"margin-bottom:0;\">Atlura (Lurasidone 20 \/ 40 \/ 80 mg) is an atypical antipsychotic for schizophrenia and bipolar depression. <strong>Must be taken with food (\u2265 350 kcal)<\/strong> \u2014 fasting halves absorption and produces treatment failure. Metabolically among the cleanest atypicals.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Hva du f\u00e5r med MedsBase:<\/strong> WHO-GMP-sertifisert produsent \u00b7 Diskret emballasje \u00b7 Verdensomspennende levering \u00b7 1 400+ verifiserte <a href=\"https:\/\/medsbase.com\/nb\/reviews\/\">kundeanmeldelser<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Hver ordre er dekket av v\u00e5r <a href=\"https:\/\/medsbase.com\/nb\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 hvis pakken din ikke ankommer innen 20 virkedager, sender vi ny.<\/p>\n<h3>Hvorfor bestille fra MedsBase<\/h3>\n<p>Atlura at MedsBase is supplied directly from a WHO-GMP certified manufacturer in plain, discreet packaging. Every order is covered by our <a href=\"https:\/\/medsbase.com\/nb\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance Policy<\/a> \u2014 20 virkedagers leveringsvindu eller vi sender p\u00e5 nytt uten ekstra kostnad \u2014 og kvalifiserer for v\u00e5rt <a href=\"https:\/\/medsbase.com\/nb\/loyalty-points\/\">kundelojalitetsprogram<\/a>. Verdensomspennende shipping er tilgjengelig til de fleste destinasjoner.<\/p>\n<h2>What Atlura is and how it works<\/h2>\n<p>Atlura is a lurasidone tablet supplied by Healing Pharma. Available strengths: <strong>20 \/ 40 \/ 80 mg<\/strong>. Lurasidone is a D2\/5-HT2A antagonist with additional 5-HT7 antagonism (the 5-HT7 component is the basis for its bipolar-depression indication). It is one of the cleanest atypicals on metabolic markers \u2014 minimal weight gain, minimal lipid effect, minimal glucose effect.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>CRITICAL \u2014 must be taken with food (\u2265 350 kcal)<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Fasting bioavailability of lurasidone is approximately <strong>half<\/strong> the fed bioavailability. Patients who skip a meal or take the dose at a small snack reach inadequate plasma levels and frequently appear to &#8220;fail&#8221; therapy. <strong>Take with the largest meal of the day, every day, at the same time.<\/strong> A glass of milk or a small biscuit is not enough \u2014 aim for at least 350 kcal of mixed-macronutrient food.<\/p>\n<\/div>\n<h2>Indikasjoner og dosering<\/h2>\n<table>\n<thead>\n<tr>\n<th>Indikasjon<\/th>\n<th>Startdose<\/th>\n<th>M\u00e5ldose<\/th>\n<th>Maks<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Schizofreni (voksen)<\/td>\n<td>40 mg OD with food<\/td>\n<td>40\u201380 mg OD<\/td>\n<td>160 mg<\/td>\n<\/tr>\n<tr>\n<td>Schizofreni (ungdom \u2265 13 \u00e5r)<\/td>\n<td>40 mg OD with food<\/td>\n<td>40\u201380 mg OD<\/td>\n<td>80 mg<\/td>\n<\/tr>\n<tr>\n<td>Bipolar depression (adult, monotherapy or adjunct)<\/td>\n<td>20 mg OD with food<\/td>\n<td>20\u201360 mg OD<\/td>\n<td>120 mg<\/td>\n<\/tr>\n<tr>\n<td>Bipolar depression (paediatric \u2265 10 y)<\/td>\n<td>20 mg OD with food<\/td>\n<td>20\u201380 mg OD<\/td>\n<td>80 mg<\/td>\n<\/tr>\n<tr>\n<td>Nyresvikt (CrCl &lt; 50)<\/td>\n<td>20 mg OD with food<\/td>\n<td>up to 80 mg<\/td>\n<td>80 mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Viktige sikkerhetshensyn<\/h2>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>FDA black-box \u2014 demensrelatert psykose<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Alle atypiske antipsykotika b\u00e6rer en FDA black-box advarsel for \u00f8kt d\u00f8delighet (hovedsakelig kardiovaskul\u00e6r og infeksi\u00f8s) n\u00e5r de brukes til \u00e5 behandle atferdsforstyrrelser hos eldre med demens. <strong>Atypiske antipsykotika er ikke godkjent for demensrelatert psykose eller agitasjon<\/strong>. Bruk i denne populasjonen er off-label, siste utvei, tidsbegrenset, og krever eksplisitt risikovurderingssamtale.<\/p>\n<\/div>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Akathisia and EPS<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Akathisia is common at higher doses. EPS (rigidity, tremor, dystonia) less common than first-generation antipsychotics but can occur. Manageable with dose reduction or anticholinergic adjunct.<\/p>\n<\/div>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Strong CYP3A4 substrate<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Avoid concurrent strong CYP3A4 inhibitors (azoles, clarithromycin, ritonavir, grapefruit juice) \u2014 they raise lurasidone levels several-fold. Avoid strong inducers (rifampicin, carbamazepine, phenytoin, St John&rsquo;s wort) \u2014 they reduce levels into the ineffective range.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Suicidality (under-25, bipolar depression indication)<\/strong><\/p>\n<p style=\"margin-bottom:0;\">All antidepressant-class indications carry the under-25 suicidality warning.<\/p>\n<\/div>\n<h2>Vanlige bivirkninger<\/h2>\n<ul>\n<li><strong>Somnolence and sedation<\/strong> \u2014 common; usually settles.<\/li>\n<li><strong>Akatisi<\/strong> \u2014 doseavhengig.<\/li>\n<li><strong>Kvalme<\/strong> \u2014 first 1\u20132 weeks; mitigated by food (which is mandatory anyway).<\/li>\n<li><strong>EPS<\/strong> \u2014 uncommon but possible.<\/li>\n<li><strong>Vekt\u00f8kning<\/strong> \u2014 modest, generally less than olanzapine\/quetiapine.<\/li>\n<li><strong>Prolaktin<\/strong> \u2014 small dose-dependent rise.<\/li>\n<li><strong>Distinkte negative sider:<\/strong> minimal effect on lipids, glucose, QT.<\/li>\n<\/ul>\n<h2>Legemiddelinteraksjoner<\/h2>\n<ul>\n<li><strong>Sterke CYP3A4-hemmere<\/strong> \u2014 contraindicated.<\/li>\n<li><strong>Sterke CYP3A4-indusere<\/strong> \u2014 contraindicated.<\/li>\n<li><strong>Moderate CYP3A4 inhibitors<\/strong> (diltiazem, verapamil, fluconazole, erythromycin) \u2014 halve lurasidone dose; max 40 mg.<\/li>\n<li><strong>Andre CNS-depressiva<\/strong> \u2014 additiv sedering.<\/li>\n<li><strong>Other antipsychotics<\/strong> \u2014 additive EPS, prolactin, NMS risk.<\/li>\n<\/ul>\n<h2>Graviditet, amming, pediatri<\/h2>\n<p>Pregnancy: limited data; weigh against untreated illness. Breastfeeding: insufficient data; generally avoided. Paediatric: licensed from 13 (schizophrenia), 10 (bipolar depression).<\/p>\n<h2>Oppbevaring<\/h2>\n<p>Oppbevar ved 15\u201330 \u00b0C i originalemballasje.<\/p>\n<h2 id=\"faqs\">Vanlige sp\u00f8rsm\u00e5l<\/h2>\n<h3>Why does Atlura need to be taken with food?<\/h3>\n<p>Fasting absorption is approximately half of fed absorption. The food requirement is not optional \u2014 patients who take Atlura on an empty stomach often appear to fail therapy when in fact they are simply under-dosed. The minimum threshold for adequate absorption is approximately 350 kcal of mixed food (a normal meal, not a snack).<\/p>\n<h3>Why is Atlura preferred for bipolar depression?<\/h3>\n<p>Lurasidone has FDA approval for bipolar depression as monotherapy or adjunct (PREVAIL-2 trial) \u2014 one of only three atypicals with this indication (others are quetiapine and olanzapine-fluoxetine). The 5-HT7 antagonism is thought to underlie the antidepressant effect. Lurasidone is a metabolically cleaner choice than quetiapine or olanzapine for bipolar depression.<\/p>\n<h3>Will Atlura make me gain weight?<\/h3>\n<p>Less than olanzapine, clozapine, quetiapine, or risperidone \u2014 typically 1\u20132 kg over 6 months in monotherapy. One of the better metabolic profiles among atypicals.<\/p>\n<h3>How long until Atlura works?<\/h3>\n<p>Schizophrenia: positive symptoms typically improve over 2\u20134 weeks; full effect at 4\u20136 weeks. Bipolar depression: 2\u20136 weeks for full effect. Compliance with the food requirement matters \u2014 if response is poor, check that doses are being taken with adequate meals.<\/p>\n<h3>Can Atlura be combined with mood stabilisers?<\/h3>\n<p>Yes \u2014 lurasidone is FDA-approved as an adjunct to lithium or valproate in bipolar depression. Combination is common and well-tolerated.<\/p>\n<h3>What about driving on Atlura?<\/h3>\n<p>Sedation is dose-dependent. Most patients on stable doses drive normally; the first 1\u20132 weeks of titration can impair reaction time.<\/p>\n<h3>How is Atlura different from olanzapine?<\/h3>\n<p>Lurasidone has a substantially better metabolic profile (less weight gain, less glucose disturbance, less lipid disturbance) but a slightly higher rate of akathisia and somnolence. Olanzapine is more sedating and has stronger acute antipsychotic effect; lurasidone is preferred for long-term metabolic safety.<\/p>\n<h3>Can Atlura be stopped abruptly?<\/h3>\n<p>Generally taper over 1\u20132 weeks, although withdrawal is mild. The relapse risk in schizophrenia and bipolar disease is the main reason for caution \u2014 never stop without prescriber agreement.<\/p>\n<h3>Why is grapefruit juice a problem?<\/h3>\n<p>Grapefruit juice is a strong CYP3A4 inhibitor. Lurasidone is a CYP3A4 substrate; grapefruit raises levels several-fold, increasing sedation, akathisia, and EPS risk. Avoid grapefruit and grapefruit juice during Atlura therapy.<\/p>\n<h3>Does Atlura prolong the QT interval?<\/h3>\n<p>Less than ziprasidone, less than thioridazine. Lurasidone has a small QT signal but is generally regarded as one of the cleaner atypicals for QT. Pre-treatment ECG is not routinely required but is reasonable in patients with cardiac risk factors.<\/p>\n<h2>Andre psykofarmaka<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nb\/aripicon\/\">Aripicon (Aripiprazol \u2014 D2-partiell agonist)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/olanzap\/\">Olanzap (Olanzapin \u2014 kraftig antipsykotikum)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/risdone\/\">Risdone (Risperidon)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/seroquit\/\">Seroquit (Quetiapin \u2014 bipolar depresjon)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/atlura\/\">Atlura (Lurasidon \u2014 metabolsk trygg)<\/a><\/li>\n<\/ul>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;font-size:0.9em;\">\n<strong>Medisinsk ansvarsfraskrivelse.<\/strong> Denne siden er kun til informasjon og er ikke erstatning for individuell medisinsk r\u00e5dgivning. Behandling med psykofarmaka b\u00f8r startes, overv\u00e5kes og justeres av en kvalifisert lege. Hvis du eller noen du kjenner er i selvmordskrise, kontakt lokal akuttmedisinsk tjeneste umiddelbart, eller ring landets selvmordsforebyggende hjelpelinje (USA\/Canada: 988; Storbritannia: Samaritans 116 123; internasjonal liste: <a href=\"https:\/\/findahelpline.com\/\" rel=\"nofollow noopener\" target=\"_blank\">findahelpline.com<\/a>).\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Atlura (Lurasidone 20\/40\/80 mg) \u2014 5-HT7-active atypical for schizophrenia and bipolar depression. must be taken with food (\u2265350 kcal) or absorption halves.<\/p>","protected":false},"featured_media":58254,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3906],"product_tag":[4453,4454],"class_list":{"0":"post-58253","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-mental-health-and-psychiatric-medications","9":"product_tag-atlura","10":"product_tag-lurasidone","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product\/58253","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/comments?post=58253"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/media\/58254"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/media?parent=58253"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product_brand?post=58253"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product_cat?post=58253"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product_tag?post=58253"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}