{"id":59683,"date":"2024-02-28T06:10:41","date_gmt":"2024-02-28T06:10:41","guid":{"rendered":"https:\/\/medsname.com\/udimax-300\/"},"modified":"2026-04-30T10:23:56","modified_gmt":"2026-04-30T10:23:56","slug":"udimax-300","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nb\/product\/udimax-300\/","title":{"rendered":"Udimax 300"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Udimax 300?<\/h3>\n<p style=\"margin:0;\"><strong>Udimax 300<\/strong> is <strong>ursodeoxycholic acid (UDCA) 300 mg<\/strong> &mdash; a hydrophilic bile acid that is the standard of care for <strong>primary biliary cholangitis (PBC), cholesterol gallstones in patients unfit for surgery, intrahepatic cholestasis of pregnancy (ICP), bile-acid diarrhoea, and pruritus of cholestatic liver disease<\/strong>. UDCA reduces cholesterol saturation in bile, replaces toxic hydrophobic bile acids in the bile-acid pool, exerts cytoprotective and anti-apoptotic effects on hepatocytes and cholangiocytes, and stimulates bicarbonate-rich choleresis. Standard adult doses range from <strong>10&ndash;15 mg\/kg\/day for PBC and gallstones to 14&ndash;30 mg\/kg\/day for cholestasis of pregnancy<\/strong>. WHO-GMP-sertifisert produsent.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f6f8;border:1px solid #e1e4e8;border-radius:6px;padding:14px 18px;margin:24px 0;font-size:14px;\"><strong>Hvorfor bestille fra MedsBase:<\/strong> \u2714 <strong>WHO-GMP-sertifisert produsent<\/strong> \u2714 Diskret emballasje \u2714 Verdensomspennende frakt \u2714 <a href=\"https:\/\/medsbase.com\/nb\/reviews\/\">Verifiserte kundeanmeldelser (1,400+ kunder)<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Hver ordre er dekket av v\u00e5r <a href=\"https:\/\/medsbase.com\/nb\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 hvis pakken din ikke ankommer innen 20 virkedager, sender vi ny.<\/p>\n<h3>Hvorfor bestille fra MedsBase<\/h3>\n<p>V\u00e5re generiske legemidler kommer fra WHO-GMP-sertifiserte produsenter og sendes over hele verden i diskret, n\u00f8ytral emballasje \u2014 ingen legemiddelnavn p\u00e5 utsiden av pakken. Kortbetalinger h\u00e5ndteres av en regulert betalingsbehandler (kontoutskrifter viser en regulert kortbetalingsprosessor \u2014 aldri \u201cMedsBase\u201d eller noe legemiddelnavn). Krypto og SEPA bankoverf\u00f8rsel godtas ogs\u00e5. Hver ordre er dekket av v\u00e5r Reshipment Assurance Policy.<\/p>\n<div style=\"background:#f4f8fb;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>&#128161; First-line for PBC since 1994.<\/strong> UDCA is the only therapy proven to extend transplant-free survival in primary biliary cholangitis. In 30&ndash;40 percent of PBC patients ALP does not normalise on UDCA alone and obeticholic acid or a fibrate is added (specialist hepatology decision).<\/div>\n<h3 class=\"wp-block-heading\">Hvorfor bestille fra MedsBase<\/h3>\n<p>Udimax 300 is supplied from a <strong>WHO-GMP-sertifisert produsent<\/strong>. Hver ordre sendes diskret over hele verden og er dekket av v\u00e5r <a href=\"https:\/\/medsbase.com\/nb\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance Policy<\/a> &mdash; if it does not arrive within 20 business days, we reship at no cost. UDCA has been on the WHO Essential Medicines List for decades and is the cornerstone of medical therapy for cholestatic liver disease.<\/p>\n<h2 class=\"wp-block-heading\">Mekanisme<\/h2>\n<p>UDCA is a naturally occurring hydrophilic 7&beta;-hydroxy bile acid (&#8220;the bear bile acid&#8221;). When taken orally it enriches the bile-acid pool, replacing toxic hydrophobic acids (chenodeoxycholic, lithocholic) that damage cholangiocytes and hepatocytes in cholestasis. Three actions matter clinically: (1) it reduces biliary cholesterol saturation, dissolving cholesterol gallstones over months; (2) it exerts direct cytoprotective and anti-apoptotic effects on liver cells, reducing immune-mediated damage in PBC; (3) it stimulates a bicarbonate-rich &#8220;alkaline tide&#8221; choleresis, which protects cholangiocytes from the detergent action of hydrophobic bile acids. Onset of biochemical improvement in PBC is typically 2&ndash;6 months.<\/p>\n<h2 class=\"wp-block-heading\">Indications &amp; doses<\/h2>\n<table border=\"1\" cellpadding=\"6\" style=\"border-collapse:collapse;width:100%;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th>Indikasjon<\/th>\n<th>Dose<\/th>\n<th>Merknader<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Primary biliary cholangitis (PBC)<\/td>\n<td>13&ndash;15 mg\/kg\/day in 1&ndash;2 divided doses<\/td>\n<td>Livslang<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td>Cholesterol gallstones (radiolucent, non-calcified, &lt; 15 mm, functioning gallbladder)<\/td>\n<td>8&ndash;10 mg\/kg\/day<\/td>\n<td>6&ndash;24 months; recurrence common after stopping<\/td>\n<\/tr>\n<tr>\n<td>Intrahepatic cholestasis of pregnancy<\/td>\n<td>10&ndash;15 mg\/kg\/day, may rise to 25 mg\/kg\/day<\/td>\n<td>Reduces pruritus, normalises bile acids; PITCHES trial showed mixed effect on stillbirth<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td>Bile-acid diarrhoea<\/td>\n<td>250&ndash;500 mg twice daily (off-label)<\/td>\n<td>Combine with bile-acid binders (cholestyramine)<\/td>\n<\/tr>\n<tr>\n<td>PSC, cystic fibrosis liver disease, paediatric biliary atresia<\/td>\n<td>20&ndash;30 mg\/kg\/day<\/td>\n<td>Specialist supervision; high-dose in PSC limited to 20 mg\/kg\/day after a 30 mg\/kg trial showed harm<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Bivirkninger<\/h2>\n<ul>\n<li>Common: diarrhoea (dose-related), abdominal cramps, nausea<\/li>\n<li>Skin reactions (rash, pruritus &mdash; transient, opposite to its therapeutic effect on cholestatic itch)<\/li>\n<li>Calcified gallstones (rare; on long courses)<\/li>\n<li>Worsening ascites in advanced cirrhosis (rare)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Legemiddelinteraksjoner<\/h2>\n<ul>\n<li><strong>Cholestyramine, colestipol, antacids (aluminium):<\/strong> bind UDCA and reduce absorption &mdash; separate by 2 hours.<\/li>\n<li><strong>Combined OC pill, oestrogens, clofibrate:<\/strong> increase biliary cholesterol saturation and oppose the gallstone-dissolution effect.<\/li>\n<li><strong>Ciclosporin:<\/strong> UDCA may improve ciclosporin absorption; monitor levels.<\/li>\n<li><strong>Nitrendipine, dapsone:<\/strong> levels may fall on UDCA &mdash; monitor.<\/li>\n<\/ul>\n<h2 id=\"faqs\">Vanlige sp\u00f8rsm\u00e5l<\/h2>\n<h3 class=\"wp-block-heading\">Hvor lang tid tar det f\u00f8r jeg ser forbedring?<\/h3>\n<p>In PBC, ALP and ALT begin to fall within 4&ndash;8 weeks; full biochemical response is judged at 12 months. Pruritus often improves within weeks. Gallstone dissolution takes 6&ndash;24 months and only works for cholesterol stones.<\/p>\n<h3 class=\"wp-block-heading\">Will it dissolve all gallstones?<\/h3>\n<p>No. Only radiolucent, non-calcified, cholesterol stones &lt; 15 mm in a functioning gallbladder will dissolve. Pigment stones, calcified stones, and cholecystitis will not respond. Recurrence after stopping is common (~50 percent in 5 years) so cholecystectomy remains preferred when feasible.<\/p>\n<h3 class=\"wp-block-heading\">Er det trygt under svangerskap?<\/h3>\n<p>Yes. UDCA is the recognised therapy for intrahepatic cholestasis of pregnancy (ICP), reducing maternal pruritus and bile-acid levels. Discuss with obstetric prescriber.<\/p>\n<h3 class=\"wp-block-heading\">Kan jeg drikke alkohol under behandlingen?<\/h3>\n<p>Avoid heavy alcohol &mdash; it worsens any underlying liver disease. Light intake is acceptable in PBC at the prescriber&#8217;s discretion.<\/p>\n<h3 class=\"wp-block-heading\">Why do I have diarrhoea?<\/h3>\n<p>Excess UDCA reaches the colon and acts as an osmotic \/ secretory laxative. Splitting the dose (e.g. 300 mg morning and evening rather than 600 mg once) usually helps. If persistent, dose reduction is reasonable in stone-dissolution use; in PBC, prioritise the dose for biochemical response.<\/p>\n<h3 class=\"wp-block-heading\">Will I need it for life?<\/h3>\n<p>In PBC: yes. In gallstones: only until they dissolve (then stop, accept recurrence risk). In ICP: until delivery and normalisation of bile acids.<\/p>\n<h3 class=\"wp-block-heading\">Skal jeg ta det med mat?<\/h3>\n<p>Take with meals. Bile-acid recycling during the postprandial period maximises enterohepatic circulation and the therapeutic effect.<\/p>\n<h3 class=\"wp-block-heading\">Can I take it with cholestyramine?<\/h3>\n<p>Yes, but separate by 2 hours &mdash; cholestyramine binds bile acids and would inactivate the dose if taken simultaneously.<\/p>\n<h3 class=\"wp-block-heading\">Oppbevaring<\/h3>\n<p>Below 25&deg;C, dry place. Keep tablets in the original blister.<\/p>\n<h3 class=\"wp-block-heading\">Hva om jeg glemmer en dose?<\/h3>\n<p>Take it as soon as you remember. If close to the next dose, skip it. Do not double up.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Andre magehelsmedikamenter<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nb\/maxiliv-injection\/\">Maxiliv Injection &mdash; Glutathione (antioxidant)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/liv-52-ds\/\">Liv 52 DS &mdash; Ayurvedic hepatoprotective<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/asacol\/\">Asacol &mdash; Mesalamine 400 mg (UC)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/saaz\/\">Saaz &mdash; Sulfasalazine<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/budez-cr\/\">Budez CR &mdash; Budesonide CR (autoimmune hepatitis off-label)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/gastro-health\/\"><strong>Se alle gastrohelsemedisiner<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Medisinsk ansvarsfraskrivelse.<\/strong> This page is for informational purposes only and does not replace medical advice from a qualified healthcare professional. PBC, PSC, ICP, and cholestatic liver disease all need specialist hepatology supervision. Acute right-upper-quadrant pain, jaundice, fever, or pale stools needs urgent assessment.<\/div>","protected":false},"excerpt":{"rendered":"<p>Udimax 300 (Ursodeoxycholic Acid 300 mg) \u2014 hydrophilic bile acid for primary biliary cholangitis, cholesterol gallstones, intrahepatic cholestasis of pregnancy, and bile-acid diarrhoea. WHO Essential Medicine for PBC. Worldwide shipping from MedsBase.<\/p>","protected":false},"featured_media":59684,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3542,3342],"product_tag":[4727,4728],"class_list":{"0":"post-59683","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-gastro-health","8":"product_cat-general-health","9":"product_tag-udimax-300","10":"product_tag-ursodeoxycholic-acid","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product\/59683","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/comments?post=59683"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/media\/59684"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/media?parent=59683"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product_brand?post=59683"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product_cat?post=59683"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product_tag?post=59683"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}