{"id":59771,"date":"2024-02-28T06:15:46","date_gmt":"2024-02-28T06:15:46","guid":{"rendered":"https:\/\/medsname.com\/waf-5\/"},"modified":"2026-05-01T10:49:15","modified_gmt":"2026-05-01T10:49:15","slug":"waf-5","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nb\/product\/waf-5\/","title":{"rendered":"Waf-5"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Waf-5?<\/h3>\n<p style=\"margin:0;\"><strong>Waf-5<\/strong> is 5 mg warfarin tablets from a WHO-GMP certified manufacturer &mdash; vitamin K antagonist (VKA) &mdash; oral anticoagulant. Warfarin was introduced in 1954 after synthesis from dicoumarol (the rat poison compound that caused cattle haemorrhage after spoiled sweet clover consumption in 1920s Wisconsin). Named after the Wisconsin Alumni Research Foundation (WARF) that funded its development. Remains essential for mechanical heart valves, moderate-severe mitral stenosis, and patients where DOACs are contraindicated. blocks vitamin K epoxide reductase (VKORC1), preventing regeneration of reduced vitamin K required for carboxylation of clotting factors II, VII, IX, X and proteins C and S. Takes 3-5 days to reach full effect (factor II half-life ~60 hours). Dosing: <strong>Individualised to INR target<\/strong> (2.0-3.0 for most indications; 2.5-3.5 for mechanical valves). Starting dose 5 mg daily for 2-3 days then adjusted by INR; 2-4 mg daily typical maintenance; wide inter-individual variation driven by CYP2C9 and VKORC1 genotype plus diet. <strong>Bl\u00f8dningsrisiko:<\/strong> major bleeding ~3-5%\/year at therapeutic INR; rises sharply with supratherapeutic INR, acute illness, and interacting drugs. Reversal with vitamin K (slow, hours), 4-factor PCC, or fresh frozen plasma (emergencies). Anticoagulant and antiplatelet selection is individualised to diagnosis, bleeding risk, renal function, and drug interactions. Specialist or family-physician supervision is standard.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Hva du f\u00e5r med MedsBase:<\/strong> WHO-GMP-sertifisert produsent \u00b7 Diskret emballasje \u00b7 Verdensomspennende levering \u00b7 1 400+ verifiserte <a href=\"https:\/\/medsbase.com\/nb\/reviews\/\">kundeanmeldelser<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Hver ordre er dekket av v\u00e5r <a href=\"https:\/\/medsbase.com\/nb\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 hvis pakken din ikke ankommer innen 20 virkedager, sender vi ny.<\/p>\n<h3>Hvorfor bestille fra MedsBase<\/h3>\n<p>V\u00e5re generiske legemidler kommer fra WHO-GMP-sertifiserte produsenter og sendes over hele verden i diskret, n\u00f8ytral emballasje \u2014 ingen legemiddelnavn p\u00e5 utsiden av pakken. Kortbetalinger h\u00e5ndteres av en regulert betalingsbehandler (kontoutskrifter viser en regulert kortbetalingsprosessor \u2014 aldri \u201cMedsBase\u201d eller noe legemiddelnavn). Krypto og SEPA bankoverf\u00f8rsel godtas ogs\u00e5. Hver ordre er dekket av v\u00e5r Reshipment Assurance Policy.<\/p>\n<h2 class=\"wp-block-heading\">What Is Waf-5?<\/h2>\n<p>Waf-5 is 5 mg warfarin tablets from a WHO-GMP certified manufacturer, supplied in 30-180 tablets. Warfarin was introduced in 1954 after synthesis from dicoumarol (the rat poison compound that caused cattle haemorrhage after spoiled sweet clover consumption in 1920s Wisconsin). Named after the Wisconsin Alumni Research Foundation (WARF) that funded its development. Remains essential for mechanical heart valves, moderate-severe mitral stenosis, and patients where DOACs are contraindicated.<\/p>\n<h2 class=\"wp-block-heading\">Hvordan Warfarin Virker<\/h2>\n<p>Warfarin blocks vitamin K epoxide reductase (VKORC1), preventing regeneration of reduced vitamin K required for carboxylation of clotting factors II, VII, IX, X and proteins C and S. Takes 3-5 days to reach full effect (factor II half-life ~60 hours).<\/p>\n<h2 class=\"wp-block-heading\">Godkjente Bruksomr\u00e5der<\/h2>\n<ul>\n<li><strong>Mekaniske hjerteklaffer<\/strong> &mdash; only warfarin is approved (DOACs are contraindicated)<\/li>\n<li><strong>Moderate-severe mitral stenosis with AF<\/strong> &mdash; warfarin preferred<\/li>\n<li><strong>Atrieflimmer<\/strong> &mdash; DOACs are now first-line in most markets; warfarin remains where DOACs are contraindicated (severe CKD, concurrent strong inhibitors)<\/li>\n<li><strong>VTE treatment and secondary prevention<\/strong> &mdash; largely displaced by DOACs<\/li>\n<li><strong>Antiphospholipid syndrome<\/strong> &mdash; warfarin still preferred (RCTs suggested DOAC inferiority)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Dosering<\/h2>\n<p><strong>Individualised to INR target<\/strong> (2.0-3.0 for most indications; 2.5-3.5 for mechanical valves). Starting dose 5 mg daily for 2-3 days then adjusted by INR; 2-4 mg daily typical maintenance; wide inter-individual variation driven by CYP2C9 and VKORC1 genotype plus diet.<\/p>\n<h2 class=\"wp-block-heading\">Bl\u00f8dningsrisiko og overv\u00e5kning<\/h2>\n<p><strong>Bl\u00f8dningsrisiko:<\/strong> major bleeding ~3-5%\/year at therapeutic INR; rises sharply with supratherapeutic INR, acute illness, and interacting drugs. Reversal with vitamin K (slow, hours), 4-factor PCC, or fresh frozen plasma (emergencies).<\/p>\n<p><strong>INR monitoring is essential.<\/strong> Check every 3-4 days on initiation until stable; then weekly-fortnightly for a month; then monthly once stable (or longer in experienced patients). Acute illness, antibiotic courses, diet changes, and new medications all warrant earlier checks.<\/p>\n<h2 class=\"wp-block-heading\">Bivirkninger<\/h2>\n<ul>\n<li>Bleeding &mdash; major 3-5%\/year at therapeutic INR<\/li>\n<li>Warfarin skin necrosis (rare; 3-10 days after initiation, especially in protein C\/S deficiency)<\/li>\n<li>Purple toe syndrome (rare cholesterol embolisation)<\/li>\n<li>Hair loss<\/li>\n<li>Hepatotoksisk (sjeldent)<\/li>\n<li>INR instability &mdash; diet changes, acute illness, interacting drugs all destabilise<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Kontraindikasjoner<\/h2>\n<ul>\n<li>Active bleeding<\/li>\n<li>Alvorlig ukontrollert hypertensjon<\/li>\n<li>Recent major surgery or trauma<\/li>\n<li>Aktiv mages\u00e5r<\/li>\n<li>Alvorlig leversvikt<\/li>\n<li>Pregnancy &mdash; warfarin is teratogenic (first trimester) and causes fetal haemorrhage (third trimester); use LMWH<\/li>\n<li>Planned pregnancy (use LMWH)<\/li>\n<li>Inability to attend INR monitoring<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Legemiddelinteraksjoner<\/h2>\n<ul>\n<li><strong>Many drugs alter INR &mdash; extensive interaction list.<\/strong> Notable: <strong>antibiotika<\/strong> (ciprofloxacin, metronidazole, trimethoprim-sulfamethoxazole, erythromycin, clarithromycin raise INR; rifampicin lowers it), <strong>amiodarone<\/strong> (roughly doubles INR), <strong>fluconazole, miconazole<\/strong> (raise INR substantially), <strong>phenytoin, carbamazepine, rifampicin<\/strong> (lower INR).<\/li>\n<li><strong>Dietary vitamin K<\/strong> &mdash; large changes in vitamin K intake (leafy greens) destabilise INR. Keep intake consistent rather than avoiding vitamin K entirely.<\/li>\n<li><strong>Alkohol<\/strong> &mdash; acute heavy intake raises INR; chronic heavy intake can lower it. Moderate, consistent intake is OK.<\/li>\n<li><strong>NSAIDs, SSRIs, antiplatelets<\/strong> &mdash; additive bleeding without INR change.<\/li>\n<li><strong>Warfarin sensitivity is genotype-dependent<\/strong> &mdash; CYP2C9 and VKORC1 variants affect required dose 2-3 fold.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Oppbevaring<\/h2>\n<p>Store Waf-5 below 25&deg;C. Keep out of reach of children.<\/p>\n<h2 id=\"faqs\">Vanlige sp\u00f8rsm\u00e5l<\/h2>\n<h3 class=\"wp-block-heading\">Do I need blood tests on Waf-5?<\/h3>\n<p>Yes &mdash; INR monitoring is essential (every 3-4 days initially, stabilising to every 1-4 weeks). This is warfarin&rsquo;s main practical burden.<\/p>\n<h3 class=\"wp-block-heading\">What should I do if I cut myself while on Waf-5?<\/h3>\n<p>P\u00e5trykk fast direkte press i 15-20 minutter uten \u00e5 sjekke. De fleste mindre kutt stopper normalt; bl\u00f8dning som fortsetter &gt;20 minutter eller bl\u00f8r gjennom flere bandasjer krever akutt medisinsk vurdering. Rapporter eventuelle svarte eller blodige avf\u00f8ringer, lyse r\u00f8de rektale bl\u00f8dninger, hematuri, uforklarlige bl\u00e5merker, nesebl\u00f8dning &gt;15 minutter, eller menstruasjonsbl\u00f8dning som er betydelig tyngre enn vanlig.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Waf-5 in pregnancy?<\/h3>\n<p>No &mdash; warfarin is teratogenic in first trimester and causes fetal haemorrhage in third. Switch to LMWH before conception.<\/p>\n<h3 class=\"wp-block-heading\">Hva hvis jeg trenger operasjon?<\/h3>\n<p>Inform the surgical team well in advance. Warfarin is typically stopped 5 days before major surgery; may require bridging with LMWH in high thrombosis risk.<\/p>\n<h3 class=\"wp-block-heading\">Where can I buy Waf-5 online?<\/h3>\n<p>You can buy Waf-5 (warfarin 5 mg, 30-180 tablets) from MedsBase with discreet packaging and worldwide shipping.<\/p>\n<h2 class=\"wp-block-heading\">Relaterte kardiovaskul\u00e6re legemidler<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nb\/aldactone\/\">Aldactone \u2014 Spironolactone<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/cordarone\/\">Cordarone \u2014 Amiodaron 100\/200 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/ecopril\/\">Ecopril \u2014 Clopidogrel 75 mg (platehemmende)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/lonitab\/\">Lonitab \u2014 Minoxidil 5 mg (oralt vaskul\u00e6rt dilaterende middel)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/rioci-1\/\">Rioci 1 \u2014 Riociguat 1 mg (sGC-stimulator for PAH)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/vymada\/\">Vymada \u2014 Sacubitril\/Valsartan ARNI<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/high-blood-pressure-medication\/\"><strong>Se alle h\u00f8yt blodtrykksmedikamenter<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Medisinsk ansvarsfraskrivelse.<\/strong> Denne siden er kun til informasjonsform\u00e5l og erstatter ikke medisinsk r\u00e5dgivning fra en kvalifisert helsepersonell. H\u00f8yt blodtrykk, hjertesvikt og arytmier krever diagnose, overv\u00e5kning og dosindividualisering av en lege \u2013 bruk alltid betablokkere under medisinsk veiledning.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Relaterte alternativer<\/h3>\n<p>Andre produkter innen <strong>Kroniske tilstander<\/strong> som kunder ogs\u00e5 ser p\u00e5:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nb\/p-nolol-sr\/\">P-Nolol SR<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/choltran-sachet\/\">Choltran Sachet<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/admenta\/\">Admenta<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/omnacortil\/\">Omnacortil<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/veenat\/\">Veenat<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Waf-5 is warfarin 5 mg tablets \u2014 the reference vitamin K antagonist. Introduced 1954; still essential for mechanical heart valves, moderate-severe mitral stenosis, and antiphospholipid syndrome where DOACs are contraindicated. Dose individualised to INR (2.0-3.0 most indications, 2.5-3.5 mechanical valves). Extensive drug and dietary interactions; CYP2C9\/VKORC1 genotype-dependent sensitivity. Regular INR monitoring mandatory. Reversed by vitamin K or 4-factor PCC.<\/p>","protected":false},"featured_media":59772,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3635,3141,3223,3342,3260,3356],"product_tag":[4741,4742],"class_list":{"0":"post-59771","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-coagulants","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_cat-general-health","10":"product_cat-heart-blood-pressure","11":"product_cat-high-blood-pressure-medication","12":"product_tag-waf-5","13":"product_tag-warfarin","15":"first","16":"instock","17":"shipping-taxable","18":"purchasable","19":"product-type-variable","20":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product\/59771","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/comments?post=59771"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/media\/59772"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/media?parent=59771"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product_brand?post=59771"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product_cat?post=59771"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product_tag?post=59771"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}